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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CAMKK2-ANAPC5 (FusionGDB2 ID:HG10645TG51433)

Fusion Gene Summary for CAMKK2-ANAPC5

check button Fusion gene summary
Fusion gene informationFusion gene name: CAMKK2-ANAPC5
Fusion gene ID: hg10645tg51433
HgeneTgene
Gene symbol

CAMKK2

ANAPC5

Gene ID

10645

51433

Gene namecalcium/calmodulin dependent protein kinase kinase 2anaphase promoting complex subunit 5
SynonymsCAMKK|CAMKKBAPC5
Cytomap('CAMKK2')('ANAPC5')

12q24.31

12q24.31

Type of geneprotein-codingprotein-coding
Descriptioncalcium/calmodulin-dependent protein kinase kinase 2CAMKK beta proteincaM-KK 2caM-KK betacaM-kinase kinase 2caM-kinase kinase betacalcium/calmodulin-dependent protein kinase betacalcium/calmodulin-dependent protein kinase kinase 2, betaanaphase-promoting complex subunit 5cyclosome subunit 5
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000402834, ENST00000404169, 
ENST00000412367, ENST00000535524, 
ENST00000324774, ENST00000337174, 
ENST00000347034, ENST00000392473, 
ENST00000392474, ENST00000446440, 
ENST00000538733, ENST00000545538, 
Fusion gene scores* DoF score12 X 17 X 9=18367 X 8 X 6=336
# samples 228
** MAII scorelog2(22/1836*10)=-3.06099062988915
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAMKK2 [Title/Abstract] AND ANAPC5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCAMKK2(121734441)-ANAPC5(121758262), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCAMKK2

GO:0006468

protein phosphorylation

11395482

HgeneCAMKK2

GO:0046777

protein autophosphorylation

11395482

TgeneANAPC5

GO:0070979

protein K11-linked ubiquitination

18485873



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-BC-A10Y-01ACAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
ChimerDB4OVTCGA-31-1959-01ACAMKK2chr12

121734441

-ANAPC5chr12

121747666

-


Top

Fusion Gene ORF analysis for CAMKK2-ANAPC5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000402834ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-3CDSENST00000402834ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-3CDSENST00000402834ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-3CDSENST00000402834ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-3CDSENST00000402834ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-3CDSENST00000402834ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-3CDSENST00000402834ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-3CDSENST00000402834ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-3CDSENST00000404169ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-3CDSENST00000404169ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-3CDSENST00000404169ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-3CDSENST00000404169ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-3CDSENST00000404169ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-3CDSENST00000404169ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-3CDSENST00000404169ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-3CDSENST00000404169ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-3CDSENST00000412367ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-3CDSENST00000412367ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-3CDSENST00000412367ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-3CDSENST00000412367ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-3CDSENST00000412367ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-3CDSENST00000412367ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-3CDSENST00000412367ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-3CDSENST00000412367ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-3CDSENST00000535524ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-3CDSENST00000535524ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-3CDSENST00000535524ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-3CDSENST00000535524ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-3CDSENST00000535524ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-3CDSENST00000535524ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-3CDSENST00000535524ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-3CDSENST00000535524ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-5UTRENST00000402834ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-5UTRENST00000402834ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-5UTRENST00000402834ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-5UTRENST00000402834ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-5UTRENST00000404169ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-5UTRENST00000404169ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-5UTRENST00000404169ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-5UTRENST00000404169ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-5UTRENST00000412367ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-5UTRENST00000412367ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-5UTRENST00000412367ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-5UTRENST00000412367ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-5UTRENST00000535524ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-5UTRENST00000535524ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-5UTRENST00000535524ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-5UTRENST00000535524ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-intronENST00000402834ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-intronENST00000402834ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-intronENST00000404169ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-intronENST00000404169ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-intronENST00000412367ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-intronENST00000412367ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
5UTR-intronENST00000535524ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
5UTR-intronENST00000535524ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000324774ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000324774ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000324774ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000324774ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000324774ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000324774ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000324774ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000324774ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000337174ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000337174ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000337174ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000337174ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000337174ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000337174ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000337174ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000337174ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000347034ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000347034ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000347034ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000347034ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000347034ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000347034ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000347034ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000347034ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000392473ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000392473ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000392473ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000392473ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000392473ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000392473ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000392473ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000392473ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000392474ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000392474ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000392474ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000392474ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000392474ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000392474ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000392474ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000392474ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000446440ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000446440ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000446440ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000446440ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000446440ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000446440ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000446440ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000446440ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000538733ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000538733ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000538733ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000538733ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000538733ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000538733ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000538733ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000538733ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000545538ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000545538ENST00000261819CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000545538ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000545538ENST00000441917CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000545538ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000545538ENST00000535482CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-3CDSENST00000545538ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-3CDSENST00000545538ENST00000541887CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-5UTRENST00000324774ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-5UTRENST00000324774ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-5UTRENST00000324774ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-5UTRENST00000324774ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-5UTRENST00000337174ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-5UTRENST00000337174ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-5UTRENST00000337174ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-5UTRENST00000337174ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-5UTRENST00000347034ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-5UTRENST00000347034ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-5UTRENST00000347034ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-5UTRENST00000347034ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-5UTRENST00000392473ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-5UTRENST00000392473ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-5UTRENST00000392473ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-5UTRENST00000392473ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-5UTRENST00000392474ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-5UTRENST00000392474ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-5UTRENST00000392474ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-5UTRENST00000392474ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-5UTRENST00000446440ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-5UTRENST00000446440ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-5UTRENST00000446440ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-5UTRENST00000446440ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-5UTRENST00000538733ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-5UTRENST00000538733ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-5UTRENST00000538733ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-5UTRENST00000538733ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-5UTRENST00000545538ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-5UTRENST00000545538ENST00000344395CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-5UTRENST00000545538ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-5UTRENST00000545538ENST00000544314CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-intronENST00000324774ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-intronENST00000324774ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-intronENST00000337174ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-intronENST00000337174ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-intronENST00000347034ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-intronENST00000347034ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-intronENST00000392473ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-intronENST00000392473ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-intronENST00000392474ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-intronENST00000392474ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-intronENST00000446440ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-intronENST00000446440ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-intronENST00000538733ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-intronENST00000538733ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-
intron-intronENST00000545538ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121758262

-
intron-intronENST00000545538ENST00000536366CAMKK2chr12

121734441

-ANAPC5chr12

121747666

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CAMKK2-ANAPC5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for CAMKK2-ANAPC5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:121734441/:121758262)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CAMKK2-ANAPC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CAMKK2-ANAPC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CAMKK2-ANAPC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CAMKK2-ANAPC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCAMKK2C0033578Prostatic Neoplasms1CTD_human
HgeneCAMKK2C0036341Schizophrenia1PSYGENET
HgeneCAMKK2C0376358Malignant neoplasm of prostate1CTD_human
HgeneCAMKK2C0919267ovarian neoplasm1CTD_human
HgeneCAMKK2C1140680Malignant neoplasm of ovary1CTD_human