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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AVIL-HIP1R (FusionGDB2 ID:HG10677TG9026)

Fusion Gene Summary for AVIL-HIP1R

check button Fusion gene summary
Fusion gene informationFusion gene name: AVIL-HIP1R
Fusion gene ID: hg10677tg9026
HgeneTgene
Gene symbol

AVIL

HIP1R

Gene ID

10677

9026

Gene nameadvillinhuntingtin interacting protein 1 related
SynonymsADVIL|DOC6|NPHS21|p92HIP12|HIP3|ILWEQ
Cytomap('AVIL')('HIP1R')

12q14.1

12q24.31

Type of geneprotein-codingprotein-coding
Descriptionadvillinhuntingtin-interacting protein 1-related proteinHIP-12HIP1-related proteinhuntingtin interacting protein 12
Modification date2020031320200320
UniProtAcc

O75366

.
Ensembl transtripts involved in fusion geneENST00000257861, ENST00000537081, 
ENST00000550083, 
Fusion gene scores* DoF score4 X 5 X 4=806 X 7 X 4=168
# samples 58
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AVIL [Title/Abstract] AND HIP1R [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAVIL(58200143)-HIP1R(123332578), # samples:2
Anticipated loss of major functional domain due to fusion event.AVIL-HIP1R seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AVIL-HIP1R seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AVIL-HIP1R seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AVIL-HIP1R seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHIP1R

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

19255499

TgeneHIP1R

GO:0032092

positive regulation of protein binding

19255499

TgeneHIP1R

GO:0050821

protein stabilization

14732715


check buttonFusion gene breakpoints across AVIL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across HIP1R (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0129-01AAVILchr12

58200143

-HIP1Rchr12

123332578

+


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Fusion Gene ORF analysis for AVIL-HIP1R

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000257861ENST00000537322AVILchr12

58200143

-HIP1Rchr12

123332578

+
5CDS-intronENST00000537081ENST00000537322AVILchr12

58200143

-HIP1Rchr12

123332578

+
5UTR-3CDSENST00000550083ENST00000253083AVILchr12

58200143

-HIP1Rchr12

123332578

+
5UTR-intronENST00000550083ENST00000537322AVILchr12

58200143

-HIP1Rchr12

123332578

+
In-frameENST00000257861ENST00000253083AVILchr12

58200143

-HIP1Rchr12

123332578

+
In-frameENST00000537081ENST00000253083AVILchr12

58200143

-HIP1Rchr12

123332578

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000537081AVILchr1258200143-ENST00000253083HIP1Rchr12123332578+59711650047631587
ENST00000257861AVILchr1258200143-ENST00000253083HIP1Rchr12123332578+6423210243152151594

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000537081ENST00000253083AVILchr1258200143-HIP1Rchr12123332578+0.003807050.99619293
ENST00000257861ENST00000253083AVILchr1258200143-HIP1Rchr12123332578+0.0051115420.9948885

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Fusion Genomic Features for AVIL-HIP1R


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AVILchr1258200142-HIP1Rchr12123332577+0.0001885110.9998115
AVILchr1258200142-HIP1Rchr12123332577+0.0001885110.9998115

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AVIL-HIP1R


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:58200143/chr12:123332578)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AVIL

O75366

.
FUNCTION: Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling (PubMed:29058690). May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly (PubMed:29058690). {ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:29058690}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAVILchr12:58200143chr12:123332578ENST00000257861-1319109_116557820.0RegionPolyphosphoinositide binding
HgeneAVILchr12:58200143chr12:123332578ENST00000257861-1319135_143557820.0RegionPolyphosphoinositide binding
HgeneAVILchr12:58200143chr12:123332578ENST00000537081-1319109_116550813.0RegionPolyphosphoinositide binding
HgeneAVILchr12:58200143chr12:123332578ENST00000537081-1319135_143550813.0RegionPolyphosphoinositide binding
HgeneAVILchr12:58200143chr12:123332578ENST00000257861-1319145_185557820.0RepeatNote=Gelsolin-like 2
HgeneAVILchr12:58200143chr12:123332578ENST00000257861-131924_73557820.0RepeatNote=Gelsolin-like 1
HgeneAVILchr12:58200143chr12:123332578ENST00000257861-1319262_306557820.0RepeatNote=Gelsolin-like 3
HgeneAVILchr12:58200143chr12:123332578ENST00000257861-1319403_454557820.0RepeatNote=Gelsolin-like 4
HgeneAVILchr12:58200143chr12:123332578ENST00000537081-1319145_185550813.0RepeatNote=Gelsolin-like 2
HgeneAVILchr12:58200143chr12:123332578ENST00000537081-131924_73550813.0RepeatNote=Gelsolin-like 1
HgeneAVILchr12:58200143chr12:123332578ENST00000537081-1319262_306550813.0RepeatNote=Gelsolin-like 3
HgeneAVILchr12:58200143chr12:123332578ENST00000537081-1319403_454550813.0RepeatNote=Gelsolin-like 4
TgeneHIP1Rchr12:58200143chr12:123332578ENST00000253083032347_599311069.0Coiled coilOntology_term=ECO:0000255
TgeneHIP1Rchr12:58200143chr12:123332578ENST00000253083032771_1012311069.0DomainI/LWEQ
TgeneHIP1Rchr12:58200143chr12:123332578ENST00000253083032867_924311069.0RegionNote=Important for actin binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAVILchr12:58200143chr12:123332578ENST00000257861-1319753_819557820.0DomainHP
HgeneAVILchr12:58200143chr12:123332578ENST00000537081-1319753_819550813.0DomainHP
HgeneAVILchr12:58200143chr12:123332578ENST00000257861-13191_731557820.0RegionCore
HgeneAVILchr12:58200143chr12:123332578ENST00000257861-1319731_819557820.0RegionHeadpiece
HgeneAVILchr12:58200143chr12:123332578ENST00000537081-13191_731550813.0RegionCore
HgeneAVILchr12:58200143chr12:123332578ENST00000537081-1319731_819550813.0RegionHeadpiece
HgeneAVILchr12:58200143chr12:123332578ENST00000257861-1319525_565557820.0RepeatNote=Gelsolin-like 5
HgeneAVILchr12:58200143chr12:123332578ENST00000257861-1319628_669557820.0RepeatNote=Gelsolin-like 6
HgeneAVILchr12:58200143chr12:123332578ENST00000537081-1319525_565550813.0RepeatNote=Gelsolin-like 5
HgeneAVILchr12:58200143chr12:123332578ENST00000537081-1319628_669550813.0RepeatNote=Gelsolin-like 6
TgeneHIP1Rchr12:58200143chr12:123332578ENST0000025308303223_151311069.0DomainENTH


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Fusion Gene Sequence for AVIL-HIP1R


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8535_8535_1_AVIL-HIP1R_AVIL_chr12_58200143_ENST00000257861_HIP1R_chr12_123332578_ENST00000253083_length(transcript)=6423nt_BP=2102nt
AGAGTGTGATCTTGTACAAGTTATTCAGCCTTTGCAAACCTCAGATTCACACAATGTAAGATGAAGAAACTCACCTTCTGAAAATTAGAG
ATAACATATGCAAAGTGAATCAATACAGGGCTTAACATATTTATCACCCCTTTGGTAAATAACCATGACGATTACCAGAGCTCTTAAGGG
CAATGGCAGGTGGGAAGCAGAACTCATGGGTGGTAATCCCCAGGCCAGCCAGGCTCACCATGTGCACTTGGACAAGTCCTTGCCCCCATC
ATTGTGAAATGGTGCAGGGATGCACCATGAGGGTGTGGCAGGATGGCTGACAACAGACTGGGAAGCAGCTCGGCAGAAAAACTGGATTGA
TGCCCACTATGGCAAGAGATATCATCTCCCCTCTTGTTCTGTGATGTTTCAGTCCTGGAAAGACAAGCATCATGCCTCTGACCAGTGCCT
TCAGGGCTGTGGACAACGACCCTGGGATCATTGTCTGGAGAATAGAGAAAATGGAGCTGGCGCTGGTGCCTGTGAGCGCCCACGGCAACT
TCTATGAGGGGGACTGCTACGTCATCCTCTCGACCCGGAGAGTGGCCAGTCTCCTATCCCAGGACATCCACTTCTGGATCGGGAAGGACT
CCTCCCAGGATGAGCAAAGCTGCGCAGCCATATATACCACACAGCTGGACGACTACCTGGGAGGCAGCCCTGTGCAGCACCGAGAGGTCC
AGTACCATGAGTCAGACACTTTCCGTGGCTACTTCAAGCAGGGCATCATCTACAAGCAGGGGGGTGTCGCCTCTGGGATGAAGCACGTGG
AGACCAATACCTACGACGTGAAGCGGCTGCTACATGTGAAAGGGAAAAGAAACATCAGGGCTACCGAGGTGGAAATGAGCTGGGACAGTT
TCAACCGAGGTGATGTCTTCTTGCTGGACCTTGGGAAAGTCATCATCCAATGGAATGGCCCAGAGAGCAACAGTGGGGAGCGCCTGAAGG
CTATGCTTCTGGCAAAGGATATTCGAGACAGGGAGCGAGGGGGCCGTGCTAAAATAGGAGTGATCGAGGGAGACAAGGAGGCAGCCAGCC
CAGAGCTGATGAAGGTCCTTCAGGACACCCTTGGCCGACGCTCCATTATCAAGCCTACAGTCCCTGATGAGATCATAGATCAGAAGCAGA
AATCAACTATCATGTTGTATCATATCTCAGATTCAGCTGGGCAGCTGGCAGTCACAGAGGTAGCAACAAGGCCTCTGGTCCAGGACTTAC
TGAACCATGATGACTGCTACATCCTGGACCAAAGTGGAACCAAAATCTACGTGTGGAAAGGAAAAGGAGCCACAAAGGCTGAAAAACAGG
CAGCCATGTCTAAAGCGCTGGGCTTCATCAAGATGAAGAGCTACCCCAGCAGCACCAATGTGGAGACCGTCAACGATGGTGCTGAGTCGG
CCATGTTCAAGCAGCTGTTCCAGAAGTGGTCAGTAAAGGACCAGACCATGGGCCTGGGGAAAACGTTCAGCATTGGTAAAATTGCTAAAG
TTTTCCAGGATAAATTTGATGTGACTCTGCTACACACCAAGCCAGAGGTAGCTGCCCAGGAAAGAATGGTCGATGATGGCAACGGAAAAG
TTGAGGTCTGGAGAATTGAGAACCTGGAGCTGGTCCCTGTGGAGTATCAATGGTATGGCTTCTTTTATGGGGGAGACTGTTATCTGGTCC
TCTACACATACGAGGTAAATGGGAAGCCACATCACATCTTGTACATCTGGCAGGGCCGCCACGCCTCACAGGATGAGCTGGCAGCCTCAG
CATACCAGGCAGTGGAGGTGGATCGGCAGTTTGATGGGGCTGCTGTGCAGGTTCGAGTCAGGATGGGAACGGAGCCACGCCACTTCATGG
CCATCTTCAAAGGGAAGCTAGTTATCTTTGAGGGTGGGACTTCCAGGAAGGGAAATGCCGAGCCTGACCCTCCAGTAAGACTCTTCCAAA
TTCATGGAAATGACAAATCTAACACCAAAGCAGTGGAAGTTCCAGCCTTTGCCTCCTCCCTAAACTCCAATGATGTCTTTCTGCTGCGAA
CTCAGGCAGAGCACTACCTGTGGTATGGCAAGGCCATCAGCATCAGCAAAGCCATCAACACCCAGGAGGCCCCCGTGAAGGAGAAGCACG
CCCGGCGCATCATTCTGGGCACACACCACGAGAAGGGGGCTTTCACCTTCTGGTCCTACGCCATTGGGCTGCCGCTGCCCAGCAGCTCCA
TTCTCAGCTGGAAGTTCTGCCACGTCCTCCACAAGGTCCTTCGAGACGGGCACCCCAATGTGCTGCATGACTGCCAGCGGTACCGCAGCA
ACATCCGGGAGATTGGAGACCTGTGGGGACATTTGCATGACCGCTACGGACAGCTGGTGAATGTCTACACCAAGCTGCTGCTGACCAAGA
TCTCCTTCCACCTCAAGCATCCCCAGTTTCCCGCGGGCCTGGAGGTGACAGATGAGGTACTGGAGAAGGCAGCTGGGACCGATGTCAACA
ACATCTTCCAGCTCACTGTGGAGATGTTTGATTACATGGATTGTGAGCTGAAGCTTTCTGAATCAGTTTTCCGACAGCTCAACACGGCCA
TCGCCGTATCCCAGATGTCCTCAGGCCAGTGCCGCCTGGCCCCCCTCATCCAGGTCATCCAGGACTGCAGCCACCTCTACCACTACACGG
TCAAGCTCCTGTTCAAGCTACACTCTTGTCTCCCTGCGGACACCCTGCAAGGCCACAGGGACCGGTTCCACGAGCAGTTTCACAGCCTCA
GGAACTTCTTCCGCAGAGCCTCCGACATGCTGTACTTCAAGCGGCTCATCCAGATCCCCCGGCTGCCCGAGGGACCCCCTAACTTCCTGC
GGGCCTCAGCCCTGGCTGAGCACATCAAGCCGGTGGTGGTGATCCCCGAGGAGGCCCCGGAAGATGAGGAGCCGGAGAATCTCATTGAGA
TCAGCACAGGGCCCCCCGCGGGGGAGCCAGTGGTGGTGGCTGACCTCTTCGATCAGACGTTTGGACCCCCCAATGGGTCTGTGAAGGACG
ACAGGGACCTCCAGATTGAGAGCTTGAAGAGAGAGGTGGAAATGCTCCGCTCTGAACTGGAGAAGATCAAGCTGGAGGCCCAGCGGTACA
TCGCGCAGCTGAAGAGCCAGGTGAATGCACTGGAGGGTGAGCTGGAGGAGCAGCGGAAGCAGAAGCAGAAGGCCCTGGTGGATAATGAGC
AGCTCCGCCACGAGCTGGCCCAGCTGAGGGCTGCCCAGCTGGAGGGCGAGCGGAGCCAGGGCCTGCGTGAGGAGGCTGAGAGGAAGGCCA
GTGCCACGGAGGCGCGCTACAACAAGCTGAAGGAAAAGCACAGTGAGCTCGTCCATGTGCACGCGGAGCTGCTCAGAAAGAACGCGGACA
CAGCCAAGCAGCTGACGGTGACGCAGCAAAGCCAGGAGGAGGTGGCGCGGGTGAAGGAGCAGCTGGCCTTCCAGGTGGAGCAGGTGAAGC
GGGAGTCGGAGTTGAAGCTAGAGGAGAAGAGCGACCAGCTGGAGAAGCTCAAGAGGGAGCTGGAGGCCAAGGCCGGAGAGCTGGCCCGCG
CGCAGGAGGCCCTGAGCCACACAGAGCAGAGCAAGTCGGAGCTGAGCTCACGGCTGGACACGCTGAGTGCGGAGAAGGATGCTCTGAGTG
GAGCTGTGCGGCAGCGGGAGGCAGACCTGCTGGCGGCGCAGAGCCTGGTGCGCGAGACAGAGGCGGCGCTGAGCCGGGAGCAGCAGCGCA
GCTCCCAGGAGCAGGGCGAGTTGCAGGGCCGGCTGGCAGAGAGGGAGTCTCAGGAGCAGGGGCTGCGGCAGAGGCTGCTGGACGAGCAGT
TCGCAGTGTTGCGGGGCGCTGCTGCCGAGGCCGCGGGCATCCTGCAGGATGCCGTGAGCAAGCTGGACGACCCCCTGCACCTGCGCTGTA
CCAGCTCCCCAGACTACCTGGTGAGCAGGGCCCAGGAGGCCTTGGATGCCGTGAGCACCCTGGAGGAGGGCCACGCCCAGTACCTGACCT
CCTTGGCAGACGCCTCCGCCCTGGTGGCAGCTCTGACCCGCTTCTCCCACCTGGCTGCGGATACCATCATCAATGGCGGTGCCACCTCGC
ACCTGGCTCCCACCGACCCTGCCGACCGCCTCATAGACACCTGCAGGGAGTGCGGGGCCCGGGCTCTGGAGCTCATGGGGCAGCTGCAGG
ACCAGCAGGCTCTGCGGCACATGCAGGCCAGCCTGGTGCGGACACCCCTGCAGGGCATCCTTCAGCTGGGCCAGGAACTGAAACCCAAGA
GCCTAGATGTGCGGCAGGAGGAGCTGGGGGCCGTGGTCGACAAGGAGATGGCGGCCACATCCGCAGCCATTGAAGATGCTGTGCGGAGGA
TTGAGGACATGATGAACCAGGCACGCCACGCCAGCTCGGGGGTGAAGCTGGAGGTGAACGAGAGGATCCTCAACTCCTGCACAGACCTGA
TGAAGGCTATCCGGCTCCTGGTGACGACATCCACTAGCCTGCAGAAGGAGATCGTGGAGAGCGGCAGGGGGGCAGCCACGCAGCAGGAAT
TTTACGCCAAGAACTCGCGCTGGACCGAAGGCCTCATCTCGGCCTCCAAGGCTGTGGGCTGGGGAGCCACACAGCTGGTGGAGGCAGCTG
ACAAGGTGGTGCTTCACACGGGCAAGTATGAGGAGCTCATCGTCTGCTCCCACGAGATCGCAGCCAGCACGGCCCAGCTGGTGGCGGCCT
CCAAGGTGAAGGCCAACAAGCACAGCCCCCACCTGAGCCGCCTGCAGGAATGTTCTCGCACAGTCAATGAGAGGGCTGCCAATGTGGTGG
CCTCCACCAAGTCAGGCCAGGAGCAGATTGAGGACAGAGACACCATGGATTTCTCCGGCCTGTCCCTCATCAAGCTGAAGAAGCAGGAGA
TGGAGACCCAGGTGCGTGTCCTGGAGCTGGAGAAGACGCTGGAGGCTGAACGCATGCGGCTGGGGGAGTTGCGGAAGCAACACTACGTGC
TGGCTGGGGCATCAGGCAGCCCTGGAGAGGAGGTGGCCATCCGGCCCAGCACTGCCCCCCGAAGTGTAACCACCAAGAAACCACCCCTGG
CCCAGAAGCCCAGCGTGGCCCCCAGACAGGACCACCAGCTTGACAAAAAGGATGGCATCTACCCAGCTCAACTCGTGAACTACTAGGCCC
CCCAGGGGTCCAGCAGGGTGGCTGGTGACAGGCCTGGGCCTCTGCAACTGCCCTGACAGGACCGAGAGGCCTTGCCCCTCCACCTGGTGC
CCAAGCCTCCCGCCCCACCGTCTGGATCAATGTCCTCAAGGCCCCTGGCCCTTACTGAGCCTGCAGGGTCCTGGGCCATGTGGGTGGTGC
TTCTGGATGTGAGTCTCTTATTTATCTGCAGAAGGAACTTTGGGGTGCAGCCAGGACCCGGTAGGCCTGAGCCTCAACTCTTCAGAAAAT
AGTGTTTTTAATATTCCTCTTCAGAAAATAGTGTTTTTAATATTCCGAGCTAGAGCTCTTCTTCCTACGTTTGTAGTCAGCACACTGGGA
AACCGGGCCAGCGTGGGGCTCCCTGCCTTCTGGACTCCTGAAGGTCGTGGATGGATGGAAGGCACACAGCCCGTGCCGGCTGATGGGACG
AGGGTCAGGCATCCTGTCTGTGGCCTTCTGGGGCACCGATTCTACCAGGCCCTCCAGCTGCGTGGTCTCCGCAGACCAGGCTCTGTGTGG
GCTAGAGGAATGTCGCCCATTACTCCTCAGGCCTGGCCCTCGGGCCTCCGTGATGGGAGCCCCCCAGGAGGGGTCAGATGCTGGAAGGGG
CCGCTTTCTGGGGAGTGAGGTGAGACATAGCGGCCCGGGCGCTGCCTTCACTCCTGGAGTGAGTTTCCATTTCCAGCTGGAATCTGCAGC
CACCCCCATTTCCTGTTTTCCATTCCCCCGTTCTGGCCGCGCCCCACTGCCCACCTGAAGGGGTGGTTTCCAGCCCTCCGGAGAGTGGGC
TTGGCCCTAGGCCCTCCAGCTCAGCCAGAAAAAGCCCAGAAACCCAGGTGCTGGACCAGGGCCCTCAGGGAGGGGACCCTGCGGCTAGAG
TGGGCTAGGCCCTGGCTTTGCCCGTCAGATTTGAACGAATGTGTGTCCCTTGAGCCCAAGGAGAGCGGCAGGAGGGGTGGGACCAGGCTG
GGAGGACAGAGCCAGCAGCTGCCATGCCCTCCTGCTCCCCCCACCCCAGCCCTAGCCCTTTAGCCTTTCACCCTGTGCTCTGGAAAGGCT
ACCAAATACTGGCCAAGGTCAGGAGGAGCAAAAATGAGCCAGCACCAGCGCCTTGGCTTTGTGTTAGCATTTCCTCCTGAAGTGTTCTGT

>8535_8535_1_AVIL-HIP1R_AVIL_chr12_58200143_ENST00000257861_HIP1R_chr12_123332578_ENST00000253083_length(amino acids)=1594AA_BP=557
MPLTSAFRAVDNDPGIIVWRIEKMELALVPVSAHGNFYEGDCYVILSTRRVASLLSQDIHFWIGKDSSQDEQSCAAIYTTQLDDYLGGSP
VQHREVQYHESDTFRGYFKQGIIYKQGGVASGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESN
SGERLKAMLLAKDIRDRERGGRAKIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPDEIIDQKQKSTIMLYHISDSAGQLAVTEVATR
PLVQDLLNHDDCYILDQSGTKIYVWKGKGATKAEKQAAMSKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTMGLGKTFS
IGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVPVEYQWYGFFYGGDCYLVLYTYEVNGKPHHILYIWQGRHASQ
DELAASAYQAVEVDRQFDGAAVQVRVRMGTEPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSN
DVFLLRTQAEHYLWYGKAISISKAINTQEAPVKEKHARRIILGTHHEKGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHD
CQRYRSNIREIGDLWGHLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVF
RQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHSCLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPE
GPPNFLRASALAEHIKPVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESLKREVEMLRSELEKIK
LEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAEL
LRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSA
EKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDD
PLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALE
LMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERIL
NSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAAST
AQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGEL

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>8535_8535_2_AVIL-HIP1R_AVIL_chr12_58200143_ENST00000537081_HIP1R_chr12_123332578_ENST00000253083_length(transcript)=5971nt_BP=1650nt
ATGTCTTCCACGGGGCACCCTGGCTCCTACAAAATATGGGGAGAGAAAATGGAGCTGGCGCTGGTGCCTGTGAGCGCCCACGGCAACTTC
TATGAGGGGGACTGCTACGTCATCCTCTCGACCCGGAGAGTGGCCAGTCTCCTATCCCAGGACATCCACTTCTGGATCGGGAAGGACTCC
TCCCAGGATGAGCAAAGCTGCGCAGCCATATATACCACACAGCTGGACGACTACCTGGGAGGCAGCCCTGTGCAGCACCGAGAGGTCCAG
TACCATGAGTCAGACACTTTCCGTGGCTACTTCAAGCAGGGCATCATCTACAAGCAGGGGGGTGTCGCCTCTGGGATGAAGCACGTGGAG
ACCAATACCTACGACGTGAAGCGGCTGCTACATGTGAAAGGGAAAAGAAACATCAGGGCTACCGAGGTGGAAATGAGCTGGGACAGTTTC
AACCGAGGTGATGTCTTCTTGCTGGACCTTGGGAAAGTCATCATCCAATGGAATGGCCCAGAGAGCAACAGTGGGGAGCGCCTGAAGGCT
ATGCTTCTGGCAAAGGATATTCGAGACAGGGAGCGAGGGGGCCGTGCTAAAATAGGAGTGATCGAGGGAGACAAGGAGGCAGCCAGCCCA
GAGCTGATGAAGGTCCTTCAGGACACCCTTGGCCGACGCTCCATTATCAAGCCTACAGTCCCTGATGAGATCATAGATCAGAAGCAGAAA
TCAACTATCATGTTGTATCATATCTCAGATTCAGCTGGGCAGCTGGCAGTCACAGAGGTAGCAACAAGGCCTCTGGTCCAGGACTTACTG
AACCATGATGACTGCTACATCCTGGACCAAAGTGGAACCAAAATCTACGTGTGGAAAGGAAAAGGAGCCACAAAGGCTGAAAAACAGGCA
GCCATGTCTAAAGCGCTGGGCTTCATCAAGATGAAGAGCTACCCCAGCAGCACCAATGTGGAGACCGTCAACGATGGTGCTGAGTCGGCC
ATGTTCAAGCAGCTGTTCCAGAAGTGGTCAGTAAAGGACCAGACCATGGGCCTGGGGAAAACGTTCAGCATTGGTAAAATTGCTAAAGTT
TTCCAGGATAAATTTGATGTGACTCTGCTACACACCAAGCCAGAGGTAGCTGCCCAGGAAAGAATGGTCGATGATGGCAACGGAAAAGTT
GAGGTCTGGAGAATTGAGAACCTGGAGCTGGTCCCTGTGGAGTATCAATGGTATGGCTTCTTTTATGGGGGAGACTGTTATCTGGTCCTC
TACACATACGAGGTAAATGGGAAGCCACATCACATCTTGTACATCTGGCAGGGCCGCCACGCCTCACAGGATGAGCTGGCAGCCTCAGCA
TACCAGGCAGTGGAGGTGGATCGGCAGTTTGATGGGGCTGCTGTGCAGGTTCGAGTCAGGATGGGAACGGAGCCACGCCACTTCATGGCC
ATCTTCAAAGGGAAGCTAGTTATCTTTGAGGGTGGGACTTCCAGGAAGGGAAATGCCGAGCCTGACCCTCCAGTAAGACTCTTCCAAATT
CATGGAAATGACAAATCTAACACCAAAGCAGTGGAAGTTCCAGCCTTTGCCTCCTCCCTAAACTCCAATGATGTCTTTCTGCTGCGAACT
CAGGCAGAGCACTACCTGTGGTATGGCAAGGCCATCAGCATCAGCAAAGCCATCAACACCCAGGAGGCCCCCGTGAAGGAGAAGCACGCC
CGGCGCATCATTCTGGGCACACACCACGAGAAGGGGGCTTTCACCTTCTGGTCCTACGCCATTGGGCTGCCGCTGCCCAGCAGCTCCATT
CTCAGCTGGAAGTTCTGCCACGTCCTCCACAAGGTCCTTCGAGACGGGCACCCCAATGTGCTGCATGACTGCCAGCGGTACCGCAGCAAC
ATCCGGGAGATTGGAGACCTGTGGGGACATTTGCATGACCGCTACGGACAGCTGGTGAATGTCTACACCAAGCTGCTGCTGACCAAGATC
TCCTTCCACCTCAAGCATCCCCAGTTTCCCGCGGGCCTGGAGGTGACAGATGAGGTACTGGAGAAGGCAGCTGGGACCGATGTCAACAAC
ATCTTCCAGCTCACTGTGGAGATGTTTGATTACATGGATTGTGAGCTGAAGCTTTCTGAATCAGTTTTCCGACAGCTCAACACGGCCATC
GCCGTATCCCAGATGTCCTCAGGCCAGTGCCGCCTGGCCCCCCTCATCCAGGTCATCCAGGACTGCAGCCACCTCTACCACTACACGGTC
AAGCTCCTGTTCAAGCTACACTCTTGTCTCCCTGCGGACACCCTGCAAGGCCACAGGGACCGGTTCCACGAGCAGTTTCACAGCCTCAGG
AACTTCTTCCGCAGAGCCTCCGACATGCTGTACTTCAAGCGGCTCATCCAGATCCCCCGGCTGCCCGAGGGACCCCCTAACTTCCTGCGG
GCCTCAGCCCTGGCTGAGCACATCAAGCCGGTGGTGGTGATCCCCGAGGAGGCCCCGGAAGATGAGGAGCCGGAGAATCTCATTGAGATC
AGCACAGGGCCCCCCGCGGGGGAGCCAGTGGTGGTGGCTGACCTCTTCGATCAGACGTTTGGACCCCCCAATGGGTCTGTGAAGGACGAC
AGGGACCTCCAGATTGAGAGCTTGAAGAGAGAGGTGGAAATGCTCCGCTCTGAACTGGAGAAGATCAAGCTGGAGGCCCAGCGGTACATC
GCGCAGCTGAAGAGCCAGGTGAATGCACTGGAGGGTGAGCTGGAGGAGCAGCGGAAGCAGAAGCAGAAGGCCCTGGTGGATAATGAGCAG
CTCCGCCACGAGCTGGCCCAGCTGAGGGCTGCCCAGCTGGAGGGCGAGCGGAGCCAGGGCCTGCGTGAGGAGGCTGAGAGGAAGGCCAGT
GCCACGGAGGCGCGCTACAACAAGCTGAAGGAAAAGCACAGTGAGCTCGTCCATGTGCACGCGGAGCTGCTCAGAAAGAACGCGGACACA
GCCAAGCAGCTGACGGTGACGCAGCAAAGCCAGGAGGAGGTGGCGCGGGTGAAGGAGCAGCTGGCCTTCCAGGTGGAGCAGGTGAAGCGG
GAGTCGGAGTTGAAGCTAGAGGAGAAGAGCGACCAGCTGGAGAAGCTCAAGAGGGAGCTGGAGGCCAAGGCCGGAGAGCTGGCCCGCGCG
CAGGAGGCCCTGAGCCACACAGAGCAGAGCAAGTCGGAGCTGAGCTCACGGCTGGACACGCTGAGTGCGGAGAAGGATGCTCTGAGTGGA
GCTGTGCGGCAGCGGGAGGCAGACCTGCTGGCGGCGCAGAGCCTGGTGCGCGAGACAGAGGCGGCGCTGAGCCGGGAGCAGCAGCGCAGC
TCCCAGGAGCAGGGCGAGTTGCAGGGCCGGCTGGCAGAGAGGGAGTCTCAGGAGCAGGGGCTGCGGCAGAGGCTGCTGGACGAGCAGTTC
GCAGTGTTGCGGGGCGCTGCTGCCGAGGCCGCGGGCATCCTGCAGGATGCCGTGAGCAAGCTGGACGACCCCCTGCACCTGCGCTGTACC
AGCTCCCCAGACTACCTGGTGAGCAGGGCCCAGGAGGCCTTGGATGCCGTGAGCACCCTGGAGGAGGGCCACGCCCAGTACCTGACCTCC
TTGGCAGACGCCTCCGCCCTGGTGGCAGCTCTGACCCGCTTCTCCCACCTGGCTGCGGATACCATCATCAATGGCGGTGCCACCTCGCAC
CTGGCTCCCACCGACCCTGCCGACCGCCTCATAGACACCTGCAGGGAGTGCGGGGCCCGGGCTCTGGAGCTCATGGGGCAGCTGCAGGAC
CAGCAGGCTCTGCGGCACATGCAGGCCAGCCTGGTGCGGACACCCCTGCAGGGCATCCTTCAGCTGGGCCAGGAACTGAAACCCAAGAGC
CTAGATGTGCGGCAGGAGGAGCTGGGGGCCGTGGTCGACAAGGAGATGGCGGCCACATCCGCAGCCATTGAAGATGCTGTGCGGAGGATT
GAGGACATGATGAACCAGGCACGCCACGCCAGCTCGGGGGTGAAGCTGGAGGTGAACGAGAGGATCCTCAACTCCTGCACAGACCTGATG
AAGGCTATCCGGCTCCTGGTGACGACATCCACTAGCCTGCAGAAGGAGATCGTGGAGAGCGGCAGGGGGGCAGCCACGCAGCAGGAATTT
TACGCCAAGAACTCGCGCTGGACCGAAGGCCTCATCTCGGCCTCCAAGGCTGTGGGCTGGGGAGCCACACAGCTGGTGGAGGCAGCTGAC
AAGGTGGTGCTTCACACGGGCAAGTATGAGGAGCTCATCGTCTGCTCCCACGAGATCGCAGCCAGCACGGCCCAGCTGGTGGCGGCCTCC
AAGGTGAAGGCCAACAAGCACAGCCCCCACCTGAGCCGCCTGCAGGAATGTTCTCGCACAGTCAATGAGAGGGCTGCCAATGTGGTGGCC
TCCACCAAGTCAGGCCAGGAGCAGATTGAGGACAGAGACACCATGGATTTCTCCGGCCTGTCCCTCATCAAGCTGAAGAAGCAGGAGATG
GAGACCCAGGTGCGTGTCCTGGAGCTGGAGAAGACGCTGGAGGCTGAACGCATGCGGCTGGGGGAGTTGCGGAAGCAACACTACGTGCTG
GCTGGGGCATCAGGCAGCCCTGGAGAGGAGGTGGCCATCCGGCCCAGCACTGCCCCCCGAAGTGTAACCACCAAGAAACCACCCCTGGCC
CAGAAGCCCAGCGTGGCCCCCAGACAGGACCACCAGCTTGACAAAAAGGATGGCATCTACCCAGCTCAACTCGTGAACTACTAGGCCCCC
CAGGGGTCCAGCAGGGTGGCTGGTGACAGGCCTGGGCCTCTGCAACTGCCCTGACAGGACCGAGAGGCCTTGCCCCTCCACCTGGTGCCC
AAGCCTCCCGCCCCACCGTCTGGATCAATGTCCTCAAGGCCCCTGGCCCTTACTGAGCCTGCAGGGTCCTGGGCCATGTGGGTGGTGCTT
CTGGATGTGAGTCTCTTATTTATCTGCAGAAGGAACTTTGGGGTGCAGCCAGGACCCGGTAGGCCTGAGCCTCAACTCTTCAGAAAATAG
TGTTTTTAATATTCCTCTTCAGAAAATAGTGTTTTTAATATTCCGAGCTAGAGCTCTTCTTCCTACGTTTGTAGTCAGCACACTGGGAAA
CCGGGCCAGCGTGGGGCTCCCTGCCTTCTGGACTCCTGAAGGTCGTGGATGGATGGAAGGCACACAGCCCGTGCCGGCTGATGGGACGAG
GGTCAGGCATCCTGTCTGTGGCCTTCTGGGGCACCGATTCTACCAGGCCCTCCAGCTGCGTGGTCTCCGCAGACCAGGCTCTGTGTGGGC
TAGAGGAATGTCGCCCATTACTCCTCAGGCCTGGCCCTCGGGCCTCCGTGATGGGAGCCCCCCAGGAGGGGTCAGATGCTGGAAGGGGCC
GCTTTCTGGGGAGTGAGGTGAGACATAGCGGCCCGGGCGCTGCCTTCACTCCTGGAGTGAGTTTCCATTTCCAGCTGGAATCTGCAGCCA
CCCCCATTTCCTGTTTTCCATTCCCCCGTTCTGGCCGCGCCCCACTGCCCACCTGAAGGGGTGGTTTCCAGCCCTCCGGAGAGTGGGCTT
GGCCCTAGGCCCTCCAGCTCAGCCAGAAAAAGCCCAGAAACCCAGGTGCTGGACCAGGGCCCTCAGGGAGGGGACCCTGCGGCTAGAGTG
GGCTAGGCCCTGGCTTTGCCCGTCAGATTTGAACGAATGTGTGTCCCTTGAGCCCAAGGAGAGCGGCAGGAGGGGTGGGACCAGGCTGGG
AGGACAGAGCCAGCAGCTGCCATGCCCTCCTGCTCCCCCCACCCCAGCCCTAGCCCTTTAGCCTTTCACCCTGTGCTCTGGAAAGGCTAC
CAAATACTGGCCAAGGTCAGGAGGAGCAAAAATGAGCCAGCACCAGCGCCTTGGCTTTGTGTTAGCATTTCCTCCTGAAGTGTTCTGTTG

>8535_8535_2_AVIL-HIP1R_AVIL_chr12_58200143_ENST00000537081_HIP1R_chr12_123332578_ENST00000253083_length(amino acids)=1587AA_BP=550
MSSTGHPGSYKIWGEKMELALVPVSAHGNFYEGDCYVILSTRRVASLLSQDIHFWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQ
YHESDTFRGYFKQGIIYKQGGVASGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESNSGERLKA
MLLAKDIRDRERGGRAKIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPDEIIDQKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLL
NHDDCYILDQSGTKIYVWKGKGATKAEKQAAMSKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTMGLGKTFSIGKIAKV
FQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVPVEYQWYGFFYGGDCYLVLYTYEVNGKPHHILYIWQGRHASQDELAASA
YQAVEVDRQFDGAAVQVRVRMGTEPRHFMAIFKGKLVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSNDVFLLRT
QAEHYLWYGKAISISKAINTQEAPVKEKHARRIILGTHHEKGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDCQRYRSN
IREIGDLWGHLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTAI
AVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHSCLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLR
ASALAEHIKPVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYI
AQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADT
AKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSG
AVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCT
SSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQD
QQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLM
KAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAAS
KVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVL

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Fusion Gene PPI Analysis for AVIL-HIP1R


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AVIL-HIP1R


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AVIL-HIP1R


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0004238Atrial Fibrillation2CTD_human
TgeneC0005586Bipolar Disorder2PSYGENET
TgeneC0235480Paroxysmal atrial fibrillation2CTD_human
TgeneC2585653Persistent atrial fibrillation2CTD_human
TgeneC3468561familial atrial fibrillation2CTD_human