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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CNPY3-HOOK2 (FusionGDB2 ID:HG10695TG29911)

Fusion Gene Summary for CNPY3-HOOK2

check button Fusion gene summary
Fusion gene informationFusion gene name: CNPY3-HOOK2
Fusion gene ID: hg10695tg29911
HgeneTgene
Gene symbol

CNPY3

HOOK2

Gene ID

10695

29911

Gene namecanopy FGF signaling regulator 3hook microtubule tethering protein 2
SynonymsCAG4A|EIEE60|ERDA5|PRAT4A|TNRC5HK2
Cytomap('CNPY3')('HOOK2')

6p21.1

19p13.13

Type of geneprotein-codingprotein-coding
Descriptionprotein canopy homolog 3CAG repeat containingCTG repeat protein 4aexpanded repeat-domain protein CAG/CTG 5protein associated with TLR4protein associated with Toll-like receptor 4Atrinucleotide repeat-containing gene 5 proteinprotein Hook homolog 2h-hook2hHK2hook homolog 2
Modification date2020031320200327
UniProtAcc.

Q96ED9

Ensembl transtripts involved in fusion geneENST00000394142, ENST00000372836, 
Fusion gene scores* DoF score7 X 6 X 5=2109 X 10 X 6=540
# samples 712
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CNPY3 [Title/Abstract] AND HOOK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCNPY3(42903408)-HOOK2(12883858), # samples:1
Anticipated loss of major functional domain due to fusion event.CNPY3-HOOK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CNPY3-HOOK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CNPY3-HOOK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CNPY3-HOOK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CNPY3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across HOOK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-5798-01ACNPY3chr6

42903408

+HOOK2chr19

12883858

-


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Fusion Gene ORF analysis for CNPY3-HOOK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000394142ENST00000264827CNPY3chr6

42903408

+HOOK2chr19

12883858

-
3UTR-3CDSENST00000394142ENST00000397668CNPY3chr6

42903408

+HOOK2chr19

12883858

-
3UTR-intronENST00000394142ENST00000589965CNPY3chr6

42903408

+HOOK2chr19

12883858

-
5CDS-intronENST00000372836ENST00000589965CNPY3chr6

42903408

+HOOK2chr19

12883858

-
In-frameENST00000372836ENST00000264827CNPY3chr6

42903408

+HOOK2chr19

12883858

-
In-frameENST00000372836ENST00000397668CNPY3chr6

42903408

+HOOK2chr19

12883858

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000372836CNPY3chr642903408+ENST00000397668HOOK2chr1912883858-29787431762698840
ENST00000372836CNPY3chr642903408+ENST00000264827HOOK2chr1912883858-29717431762692838

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000372836ENST00000397668CNPY3chr642903408+HOOK2chr1912883858-0.0151900180.98480994
ENST00000372836ENST00000264827CNPY3chr642903408+HOOK2chr1912883858-0.015300620.9846994

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Fusion Genomic Features for CNPY3-HOOK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CNPY3-HOOK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:42903408/chr19:12883858)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HOOK2

Q96ED9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. {ECO:0000269|PubMed:17140400, ECO:0000269|PubMed:17540036, ECO:0000269|PubMed:18799622}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHOOK2chr6:42903408chr19:12883858ENST00000264827222180_42768718.0Coiled coilOntology_term=ECO:0000255
TgeneHOOK2chr6:42903408chr19:12883858ENST00000264827222455_60768718.0Coiled coilOntology_term=ECO:0000255
TgeneHOOK2chr6:42903408chr19:12883858ENST00000397668223180_42768720.0Coiled coilOntology_term=ECO:0000255
TgeneHOOK2chr6:42903408chr19:12883858ENST00000397668223455_60768720.0Coiled coilOntology_term=ECO:0000255
TgeneHOOK2chr6:42903408chr19:12883858ENST00000264827222533_71968718.0RegionNote=Required for localization to the centrosome and induction of aggresome formation
TgeneHOOK2chr6:42903408chr19:12883858ENST00000397668223533_71968720.0RegionNote=Required for localization to the centrosome and induction of aggresome formation

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCNPY3chr6:42903408chr19:12883858ENST00000372836+36153_179124279.0Coiled coilOntology_term=ECO:0000255
HgeneCNPY3chr6:42903408chr19:12883858ENST00000394142+25153_17982136.66666666666666Coiled coilOntology_term=ECO:0000255
HgeneCNPY3chr6:42903408chr19:12883858ENST00000372836+3647_271124279.0DomainNote=Saposin B-type
HgeneCNPY3chr6:42903408chr19:12883858ENST00000394142+2547_27182136.66666666666666DomainNote=Saposin B-type
TgeneHOOK2chr6:42903408chr19:12883858ENST000002648272226_12268718.0DomainCalponin-homology (CH)
TgeneHOOK2chr6:42903408chr19:12883858ENST000003976682236_12268720.0DomainCalponin-homology (CH)
TgeneHOOK2chr6:42903408chr19:12883858ENST000002648272221_16168718.0RegionNote=Required for localization to the centrosome and induction of aggresome formation
TgeneHOOK2chr6:42903408chr19:12883858ENST000003976682231_16168720.0RegionNote=Required for localization to the centrosome and induction of aggresome formation


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Fusion Gene Sequence for CNPY3-HOOK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>17836_17836_1_CNPY3-HOOK2_CNPY3_chr6_42903408_ENST00000372836_HOOK2_chr19_12883858_ENST00000264827_length(transcript)=2971nt_BP=743nt
GCAGGCTTCTTCTCGGGTCTTGGTCCTGCATCCTCTCTCTCCCAGAGCCTCCGTTAGGGGGTGGGAAAGGACTTTGCCATAGGTCGCTGA
GGCCACCATCTGCTCTCTTACTGGCCAAGGGCGTAAAAAGATAGTCTTCCCATTAGCTAGAGAGCAAACCCCAGAAAGCCTATTGGCTGC
GCCGTCCGCGGGCCTTGGTCCGCTTTGAAGGCGGGCTGCGGCTGCGAGAGGAGGGCGGGCGGGAGGCTAGCTGTTGTCGTGGTTGCTCGG
AGGCACGTGTGCAGTCCCGGAAGCGGCGAGGGGAAACTGCTCCGCGCGCGCCGCGGGAGGAGGAACCGCCCGGTCCTTTAGGGTCCGGGC
CCGGCCGGGCCATGGATTCAATGCCTGAGCCCGCGTCCCGCTGTCTTCTGCTTCTTCCCTTGCTGCTGCTGCTGCTGCTGCTGCTGCCGG
CCCCGGAGCTGGGCCCGAGCCAGGCCGGAGCTGAGGAGAACGACTGGGTTCGCCTGCCCAGCAAATGCGAAGTGTGTAAATATGTTGCTG
TGGAGCTGAAGTCAGCCTTTGAGGAAACCGGCAAGACCAAGGAGGTGATTGGCACGGGCTATGGCATCCTGGACCAGAAGGCCTCTGGAG
TCAAATACACCAAGTCGGACTTGCGGTTAATCGAAGTCACTGAGACCATTTGCAAGAGGCTCCTGGATTATAGCCTGCACAAGGAGAGGA
CCGGCAGCAATCGATTTGCCAAGGTCAGCAATCTGAAGATGGTCTTACGGAGCCTAGTAGAGTACTCCCAGGATGTCCTGGCGCATCCTG
TGTCAGAAGAGCATCTCCCAGATGTGAGCCTCATTGGAGAGTTCTCAGACCCGGCAGAGCTCGGCAAGCTGCTTCAGCTGGTGCTGGGCT
GTGCCATCAGTTGCGAGAAAAAGCAGGACCACATCCAGAGAATCATGACGCTGGAAGAATCGGTTCAGCATGTGGTGATGGAAGCCATCC
AAGAGCTCATGACCAAAGACACTCCTGACTCCCTGTCACCAGAGACGTATGGCAACTTTGACAGCCAGTCCCGCAGGTACTATTTCCTAA
GTGAGGAGGCTGAGGAGGGGGACGAATTACAGCAGCGCTGTCTGGATCTGGAGCGGCAGCTGATGCTCCTGTCAGAGGAGAAGCAGAGCC
TGGCGCAAGAGAATGCAGGGCTGCGGGAGCGGATGGGCCGGCCTGAAGGCGAGGGTACCCCAGGTCTCACTGCCAAGAAGCTGCTGCTGC
TGCAATCCCAGCTGGAGCAGTTGCAGGAGGAGAACTTCAGGCTGGAGAGTGGCAGGGAGGATGAGCGCCTGCGCTGTGCCGAGCTGGAGA
GGGAGGTTGCGGAGCTGCAGCACCGGAACCAGGCGCTGACTAGCCTGGCCCAGGAGGCACAGGCCCTGAAGGATGAGATGGATGAACTAC
GGCAGTCTTCGGAGCGTGCTGGGCAGCTGGAGGCCACGCTGACCAGTTGCCGGCGCCGCTTGGGCGAGCTGAGGGAGCTGCGGCGGCAGG
TGCGGCAGCTGGAGGAACGCAACGCCGGCCACGCCGAGCGCACGCGACAACTGGAGGATGAGCTACGCCGAGCGGGCTCCCTGCGCGCCC
AGCTGGAGGCGCAGCGGCGGCAGGTGCAGGAACTGCAGGGCCAGCGGCAGGAGGAGGCCATGAAGGCCGAGAAATGGCTATTTGAATGCC
GCAACCTGGAGGAAAAGTATGAGTCGGTGACAAAGGAGAAGGAGCGGCTGTTGGCGGAGCGGGACTCCTTGCGGGAGGCCAATGAGGAGC
TGCGCTGCGCCCAGCTGCAGCCGCGGGGGTTGACCCAGGCCGATCCCTCACTGGATCCCACCTCCACACCCGTGGATAACTTAGCCGCAG
AGATCCTGCCTGCGGAGCTCAGGGAGACGCTCCTGCGGCTTCAGCTGGAGAACAAGCGGCTGTGCAGGCAGGAGGCGGCCGACCGGGAGC
GGCAGGAGGAGCTGCAGCGCCACCTGGAGGATGCCAACCGCGCGCGCCACGGGTTGGAGACGCAGCACCGGCTGAACCAGCAGCAGCTAT
CCGAGCTGCGGGCCCAGGTGGAGGACCTGCAGAAAGCCCTGCAGGAGCAGGGGGGCAAGACTGAAGATTCCATTTTGCTGAAAAGGAAGC
TGGAGGAACATTTGCAGAAGCTTCATGAGGCAGATCTGGAGTTGCAGAGGAAGCGGGAGTACATTGAGGAGCTGGAGCCACCCACTGACA
GCAGCACAGCCCGGCGGATCGAGGAGCTGCAGCATAACTTGCAGAAGAAGGACGCGGACTTGCGGGCCATGGAGGAGCGATACCGCCGCT
ACGTGGACAAGGCCCGCATGGTCATGCAGACCATGGAACCCAAGCAGCGGCCAGCTGCGGGGGCACCTCCAGAACTCCATTCCCTGAGGA
CACAGCTCCGAGAACGGGATGTCCGCATCCGACACCTGGAGATGGACTTTGAGAAAAGCCGAAGTCAGCGGGAGCAGGAAGAAAAGCTGC
TCATCAGTGCCTGGTATAATATGGGCATGGCCTTGCAGCAGCGAGCTGGGGAGGAGCGGGCGCCTGCCCATGCCCAGTCATTCCTGGCAC
AGCAGCGGCTGGCAACCAATTCTCGCCGTGGACCCTTGGGACGCCTGGCATCTCTGAACCTTCGCCCCACTGACAAGCACTGACAGACCT
CACAATCAAGCCAGCCTGGGCTCCACCCACCCTGGCTTCCTCCAGCTCACATGGCGCCCAGCACTGGGCTTCAGCCAGGTGCTCGAGAGC
TTTGAGGCCATGATCTCTGCTCTTCCCTCTCCCAGATTGGTGGGGAGGGAGGGCGGGAGGTAGATATAGGCCTGTTCTTTTTAGCAATGT
GATTCTTGTTGTTGATTCTCTCTCTGGAGTTCATGTGCTGCCTCAGGAGACTCTGATTTTATATTTGAGAAAAATAAAGGCGTTCAATCT

>17836_17836_1_CNPY3-HOOK2_CNPY3_chr6_42903408_ENST00000372836_HOOK2_chr19_12883858_ENST00000264827_length(amino acids)=838AA_BP=189
MRRPRALVRFEGGLRLREEGGREASCCRGCSEARVQSRKRRGETAPRAPREEEPPGPLGSGPGRAMDSMPEPASRCLLLLPLLLLLLLLL
PAPELGPSQAGAEENDWVRLPSKCEVCKYVAVELKSAFEETGKTKEVIGTGYGILDQKASGVKYTKSDLRLIEVTETICKRLLDYSLHKE
RTGSNRFAKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEA
IQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL
LLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRR
QVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANE
ELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQ
LSELRAQVEDLQKALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYR
RYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFL

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>17836_17836_2_CNPY3-HOOK2_CNPY3_chr6_42903408_ENST00000372836_HOOK2_chr19_12883858_ENST00000397668_length(transcript)=2978nt_BP=743nt
GCAGGCTTCTTCTCGGGTCTTGGTCCTGCATCCTCTCTCTCCCAGAGCCTCCGTTAGGGGGTGGGAAAGGACTTTGCCATAGGTCGCTGA
GGCCACCATCTGCTCTCTTACTGGCCAAGGGCGTAAAAAGATAGTCTTCCCATTAGCTAGAGAGCAAACCCCAGAAAGCCTATTGGCTGC
GCCGTCCGCGGGCCTTGGTCCGCTTTGAAGGCGGGCTGCGGCTGCGAGAGGAGGGCGGGCGGGAGGCTAGCTGTTGTCGTGGTTGCTCGG
AGGCACGTGTGCAGTCCCGGAAGCGGCGAGGGGAAACTGCTCCGCGCGCGCCGCGGGAGGAGGAACCGCCCGGTCCTTTAGGGTCCGGGC
CCGGCCGGGCCATGGATTCAATGCCTGAGCCCGCGTCCCGCTGTCTTCTGCTTCTTCCCTTGCTGCTGCTGCTGCTGCTGCTGCTGCCGG
CCCCGGAGCTGGGCCCGAGCCAGGCCGGAGCTGAGGAGAACGACTGGGTTCGCCTGCCCAGCAAATGCGAAGTGTGTAAATATGTTGCTG
TGGAGCTGAAGTCAGCCTTTGAGGAAACCGGCAAGACCAAGGAGGTGATTGGCACGGGCTATGGCATCCTGGACCAGAAGGCCTCTGGAG
TCAAATACACCAAGTCGGACTTGCGGTTAATCGAAGTCACTGAGACCATTTGCAAGAGGCTCCTGGATTATAGCCTGCACAAGGAGAGGA
CCGGCAGCAATCGATTTGCCAAGGTCAGCAATCTGAAGATGGTCTTACGGAGCCTAGTAGAGTACTCCCAGGATGTCCTGGCGCATCCTG
TGTCAGAAGAGCATCTCCCAGATGTGAGCCTCATTGGAGAGTTCTCAGACCCGGCAGAGCTCGGCAAGCTGCTTCAGCTGGTGCTGGGCT
GTGCCATCAGTTGCGAGAAAAAGCAGGACCACATCCAGAGAATCATGACGCTGGAAGAATCGGTTCAGCATGTGGTGATGGAAGCCATCC
AAGAGCTCATGACCAAAGACACTCCTGACTCCCTGTCACCAGAGACGTATGGCAACTTTGACAGCCAGTCCCGCAGGTACTATTTCCTAA
GTGAGGAGGCTGAGGAGGGGGACGAATTACAGCAGCGCTGTCTGGATCTGGAGCGGCAGCTGATGCTCCTGTCAGAGGAGAAGCAGAGCC
TGGCGCAAGAGAATGCAGGGCTGCGGGAGCGGATGGGCCGGCCTGAAGGCGAGGGTACCCCAGGTCTCACTGCCAAGAAGCTGCTGCTGC
TGCAATCCCAGCTGGAGCAGTTGCAGGAGGAGAACTTCAGGCTGGAGAGTGGCAGGGAGGATGAGCGCCTGCGCTGTGCCGAGCTGGAGA
GGGAGGTTGCGGAGCTGCAGCACCGGAACCAGGCGCTGACTAGCCTGGCCCAGGAGGCACAGGCCCTGAAGGATGAGATGGATGAACTAC
GGCAGTCTTCGGAGCGTGCTGGGCAGCTGGAGGCCACGCTGACCAGTTGCCGGCGCCGCTTGGGCGAGCTGAGGGAGCTGCGGCGGCAGG
TGCGGCAGCTGGAGGAACGCAACGCCGGCCACGCCGAGCGCACGCGACAACTGGAGGATGAGCTACGCCGAGCGGGCTCCCTGCGCGCCC
AGCTGGAGGCGCAGCGGCGGCAGGTGCAGGAACTGCAGGGCCAGCGGCAGGAGGAGGCCATGAAGGCCGAGAAATGGCTATTTGAATGCC
GCAACCTGGAGGAAAAGTATGAGTCGGTGACAAAGGAGAAGGAGCGGCTGTTGGCGGAGCGGGACTCCTTGCGGGAGGCCAATGAGGAGC
TGCGCTGCGCCCAGCTGCAGCCGCGGGGGTTGACCCAGGCCGATCCCTCACTGGATCCCACCTCCACACCCGTGGATAACTTAGCCGCAG
AGATCCTGCCTGCGGAGCTCAGGGAGACGCTCCTGCGGCTTCAGCTGGAGAACAAGCGGCTGTGCAGGCAGGAGGCGGCCGACCGGGAGC
GGCAGGAGGAGCTGCAGCGCCACCTGGAGGATGCCAACCGCGCGCGCCACGGGTTGGAGACGCAGCACCGGCTGAACCAGCAGCAGCTAT
CCGAGCTGCGGGCCCAGGTGGAGGACCTGCAGAAAGCCCTGCAGGAGCAGGGGGGCAAGACTGAAGATGCCATTTCCATTTTGCTGAAAA
GGAAGCTGGAGGAACATTTGCAGAAGCTTCATGAGGCAGATCTGGAGTTGCAGAGGAAGCGGGAGTACATTGAGGAGCTGGAGCCACCCA
CTGACAGCAGCACAGCCCGGCGGATCGAGGAGCTGCAGCATAACTTGCAGAAGAAGGACGCGGACTTGCGGGCCATGGAGGAGCGATACC
GCCGCTACGTGGACAAGGCCCGCATGGTCATGCAGACCATGGAACCCAAGCAGCGGCCAGCTGCGGGGGCACCTCCAGAACTCCATTCCC
TGAGGACACAGCTCCGAGAACGGGATGTCCGCATCCGACACCTGGAGATGGACTTTGAGAAAAGCCGAAGTCAGCGGGAGCAGGAAGAAA
AGCTGCTCATCAGTGCCTGGTATAATATGGGCATGGCCTTGCAGCAGCGAGCTGGGGAGGAGCGGGCGCCTGCCCATGCCCAGTCATTCC
TGGCACAGCAGCGGCTGGCAACCAATTCTCGCCGTGGACCCTTGGGACGCCTGGCATCTCTGAACCTTCGCCCCACTGACAAGCACTGAC
AGACCTCACAATCAAGCCAGCCTGGGCTCCACCCACCCTGGCTTCCTCCAGCTCACATGGCGCCCAGCACTGGGCTTCAGCCAGGTGCTC
GAGAGCTTTGAGGCCATGATCTCTGCTCTTCCCTCTCCCAGATTGGTGGGGAGGGAGGGCGGGAGGTAGATATAGGCCTGTTCTTTTTAG
CAATGTGATTCTTGTTGTTGATTCTCTCTCTGGAGTTCATGTGCTGCCTCAGGAGACTCTGATTTTATATTTGAGAAAAATAAAGGCGTT

>17836_17836_2_CNPY3-HOOK2_CNPY3_chr6_42903408_ENST00000372836_HOOK2_chr19_12883858_ENST00000397668_length(amino acids)=840AA_BP=189
MRRPRALVRFEGGLRLREEGGREASCCRGCSEARVQSRKRRGETAPRAPREEEPPGPLGSGPGRAMDSMPEPASRCLLLLPLLLLLLLLL
PAPELGPSQAGAEENDWVRLPSKCEVCKYVAVELKSAFEETGKTKEVIGTGYGILDQKASGVKYTKSDLRLIEVTETICKRLLDYSLHKE
RTGSNRFAKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEA
IQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL
LLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRR
QVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANE
ELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQ
LSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEER
YRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQS

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Fusion Gene PPI Analysis for CNPY3-HOOK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CNPY3-HOOK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CNPY3-HOOK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCNPY3C0037769West Syndrome1ORPHANET
HgeneCNPY3C4693663EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 601GENOMICS_ENGLAND;UNIPROT