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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AHCYL1-ZFYVE9 (FusionGDB2 ID:HG10768TG9372)

Fusion Gene Summary for AHCYL1-ZFYVE9

check button Fusion gene summary
Fusion gene informationFusion gene name: AHCYL1-ZFYVE9
Fusion gene ID: hg10768tg9372
HgeneTgene
Gene symbol

AHCYL1

ZFYVE9

Gene ID

10768

9372

Gene nameadenosylhomocysteinase like 1zinc finger FYVE-type containing 9
SynonymsDCAL|IRBIT|PPP1R78|PRO0233|XPVKONAMADHIP|NSP|PPP1R173|SARA|SMADIP
Cytomap('AHCYL1')('ZFYVE9')

1p13.3

1p32.3

Type of geneprotein-codingprotein-coding
DescriptionS-adenosylhomocysteine hydrolase-like protein 1DC-expressed AHCY-like moleculeIP(3)Rs binding protein released with IP(3)S-adenosyl homocysteine hydrolase homologS-adenosyl-L-homocysteine hydrolase 2adenosylhomocysteinase 2adoHcyase 2dendritic cellzinc finger FYVE domain-containing protein 9MAD, mothers against decapentaplegic homolog interacting protein, receptor activation anchorMADH-interacting proteinnovel serine proteaseprotein phosphatase 1, regulatory subunit 173smad anchor for receptor
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000475081, ENST00000369799, 
ENST00000359172, ENST00000393614, 
Fusion gene scores* DoF score12 X 9 X 4=4327 X 6 X 4=168
# samples 147
** MAII scorelog2(14/432*10)=-1.6256044852185
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AHCYL1 [Title/Abstract] AND ZFYVE9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAHCYL1(110527794)-ZFYVE9(52798440), # samples:1
Anticipated loss of major functional domain due to fusion event.AHCYL1-ZFYVE9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AHCYL1-ZFYVE9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAHCYL1

GO:0006378

mRNA polyadenylation

19224921

HgeneAHCYL1

GO:0031440

regulation of mRNA 3'-end processing

19224921

HgeneAHCYL1

GO:0038166

angiotensin-activated signaling pathway

20584908

HgeneAHCYL1

GO:0051592

response to calcium ion

18829453


check buttonFusion gene breakpoints across AHCYL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ZFYVE9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GH-01AAHCYL1chr1

110527794

+ZFYVE9chr1

52798440

+


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Fusion Gene ORF analysis for AHCYL1-ZFYVE9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000475081ENST00000287727AHCYL1chr1

110527794

+ZFYVE9chr1

52798440

+
3UTR-3CDSENST00000475081ENST00000357206AHCYL1chr1

110527794

+ZFYVE9chr1

52798440

+
3UTR-3CDSENST00000475081ENST00000371591AHCYL1chr1

110527794

+ZFYVE9chr1

52798440

+
3UTR-3UTRENST00000475081ENST00000469134AHCYL1chr1

110527794

+ZFYVE9chr1

52798440

+
5CDS-3UTRENST00000369799ENST00000469134AHCYL1chr1

110527794

+ZFYVE9chr1

52798440

+
In-frameENST00000369799ENST00000287727AHCYL1chr1

110527794

+ZFYVE9chr1

52798440

+
In-frameENST00000369799ENST00000357206AHCYL1chr1

110527794

+ZFYVE9chr1

52798440

+
In-frameENST00000369799ENST00000371591AHCYL1chr1

110527794

+ZFYVE9chr1

52798440

+
intron-3CDSENST00000359172ENST00000287727AHCYL1chr1

110527794

+ZFYVE9chr1

52798440

+
intron-3CDSENST00000359172ENST00000357206AHCYL1chr1

110527794

+ZFYVE9chr1

52798440

+
intron-3CDSENST00000359172ENST00000371591AHCYL1chr1

110527794

+ZFYVE9chr1

52798440

+
intron-3CDSENST00000393614ENST00000287727AHCYL1chr1

110527794

+ZFYVE9chr1

52798440

+
intron-3CDSENST00000393614ENST00000357206AHCYL1chr1

110527794

+ZFYVE9chr1

52798440

+
intron-3CDSENST00000393614ENST00000371591AHCYL1chr1

110527794

+ZFYVE9chr1

52798440

+
intron-3UTRENST00000359172ENST00000469134AHCYL1chr1

110527794

+ZFYVE9chr1

52798440

+
intron-3UTRENST00000393614ENST00000469134AHCYL1chr1

110527794

+ZFYVE9chr1

52798440

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000369799AHCYL1chr1110527794+ENST00000357206ZFYVE9chr152798440+1621487401326428
ENST00000369799AHCYL1chr1110527794+ENST00000287727ZFYVE9chr152798440+1791487401326428
ENST00000369799AHCYL1chr1110527794+ENST00000371591ZFYVE9chr152798440+1792487401326428

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369799ENST00000357206AHCYL1chr1110527794+ZFYVE9chr152798440+0.0014194440.9985806
ENST00000369799ENST00000287727AHCYL1chr1110527794+ZFYVE9chr152798440+0.0016904970.9983095
ENST00000369799ENST00000371591AHCYL1chr1110527794+ZFYVE9chr152798440+0.001675190.9983248

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Fusion Genomic Features for AHCYL1-ZFYVE9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AHCYL1chr1110527794+ZFYVE9chr152798439+6.48E-111
AHCYL1chr1110527794+ZFYVE9chr152798439+6.48E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AHCYL1-ZFYVE9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:110527794/chr1:52798440)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAHCYL1chr1:110527794chr1:52798440ENST00000359172+117318_3220484.0Nucleotide bindingNAD
HgeneAHCYL1chr1:110527794chr1:52798440ENST00000359172+117397_3990484.0Nucleotide bindingNAD
HgeneAHCYL1chr1:110527794chr1:52798440ENST00000369799+117318_32240531.0Nucleotide bindingNAD
HgeneAHCYL1chr1:110527794chr1:52798440ENST00000369799+117397_39940531.0Nucleotide bindingNAD
HgeneAHCYL1chr1:110527794chr1:52798440ENST00000393614+117318_3220484.0Nucleotide bindingNAD
HgeneAHCYL1chr1:110527794chr1:52798440ENST00000393614+117397_3990484.0Nucleotide bindingNAD
HgeneAHCYL1chr1:110527794chr1:52798440ENST00000359172+117281_4480484.0RegionNAD binding
HgeneAHCYL1chr1:110527794chr1:52798440ENST00000359172+117520_5300484.0RegionPDZ-binding
HgeneAHCYL1chr1:110527794chr1:52798440ENST00000359172+11765_920484.0RegionPEST
HgeneAHCYL1chr1:110527794chr1:52798440ENST00000369799+117281_44840531.0RegionNAD binding
HgeneAHCYL1chr1:110527794chr1:52798440ENST00000369799+117520_53040531.0RegionPDZ-binding
HgeneAHCYL1chr1:110527794chr1:52798440ENST00000369799+11765_9240531.0RegionPEST
HgeneAHCYL1chr1:110527794chr1:52798440ENST00000393614+117281_4480484.0RegionNAD binding
HgeneAHCYL1chr1:110527794chr1:52798440ENST00000393614+117520_5300484.0RegionPDZ-binding
HgeneAHCYL1chr1:110527794chr1:52798440ENST00000393614+11765_920484.0RegionPEST
TgeneZFYVE9chr1:110527794chr1:52798440ENST000002877271219767_82311461426.0RegionNote=SBD
TgeneZFYVE9chr1:110527794chr1:52798440ENST000003572061118767_82310871367.0RegionNote=SBD
TgeneZFYVE9chr1:110527794chr1:52798440ENST000003715911118767_82311461426.0RegionNote=SBD
TgeneZFYVE9chr1:110527794chr1:52798440ENST000002877271219699_75811461426.0Zinc fingerFYVE-type
TgeneZFYVE9chr1:110527794chr1:52798440ENST000003572061118699_75810871367.0Zinc fingerFYVE-type
TgeneZFYVE9chr1:110527794chr1:52798440ENST000003715911118699_75811461426.0Zinc fingerFYVE-type


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Fusion Gene Sequence for AHCYL1-ZFYVE9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3058_3058_1_AHCYL1-ZFYVE9_AHCYL1_chr1_110527794_ENST00000369799_ZFYVE9_chr1_52798440_ENST00000287727_length(transcript)=1791nt_BP=487nt
CAGAGTGCCCTTTCTCCCCGCCTCTTCCCCCTCCCGGGAGCTGCCAGTACTTGACGTGGCGTCACCGCCCTCTACCCTCGCTTTGCGTGC
GTGTTTGCGTACAGCGGAGGTGGCGGCGCGGGCAGGTCGGAGCTCGGAGCTGCTGTTCTGGTTCTCTTGTGGCCGCCGTCGCTGTCCGGC
TGCCTTGGGCTGCCGAACAGACAAGGCGTGGGCCACAGCACCTCAGAAGCCGACGCAGCTCGACGCAGGGGCCGGCAGGAGGGTGGGCGA
TCGCGTGTCGGAGGGCGCCGCGCGGGCAGGCGGGCGGGCGCCAGAGGGGGAAAGAGGCGGGGGCGGCGGGTCAGCCGCTGGCCGGGCCGG
CCGGGGAATGTCGATGCCTGACGCGATGCCGCTGCCCGGGGTCGGGGAGGAGCTGAAGCAGGCCAAGGAGATCGAGGACGCCGAGAAGTA
CTCCTTCATGGCCACCGTCACCAAGGCGCCCAAGAAGATGATGAAAGCCATGAACAAGTCCAATGAGCATGTCCTGGCAGGAGGTGCCTG
CTTCAATGAAAAGGCAGACTCTCATCTTGTGTGTGTACAGAATGATGATGGAAACTATCAGACCCAGGCTATCAGTATTCACAATCAGCC
CAGAAAAGTGACTGGTGCCAGTTTCTTTGTGTTCAGTGGCGCTCTGAAATCCTCTTCTGGATACCTTGCCAAGTCCAGTATTGTGGAAGA
TGGTGTTATGGTCCAGATTACTGCAGAGAACATGGATTCCTTGAGGCAGGCACTGCGAGAGATGAAGGACTTCACCATCACCTGTGGGAA
GGCGGACGCGGAGGAACCCCAGGAGCACATCCACATCCAGTGGGTGGATGATGACAAGAACGTTAGCAAGGGTGTCGTAAGTCCTATAGA
TGGGAAGTCCATGGAGACTATAACAAATGTGAAGATATTCCATGGATCAGAATATAAAGCAAATGGAAAAGTAATCAGATGGACAGAGGT
GTTTTTCCTAGAAAACGATGACCAGCACAATTGCCTCAGTGATCCTGCAGATCACAGTAGATTGACTGAGCATGTTGCCAAAGCTTTTTG
CCTTGCTCTCTGTCCTCACCTGAAACTTCTGAAGGAAGATGGAATGACCAAACTGGGACTACGTGTGACACTTGACTCAGATCAGGTTGG
CTATCAAGCAGGGAGCAATGGCCAGCCCCTTCCCTCGCAGTACATGAATGATCTGGACAGCGCCTTGGTGCCGGTGATCCATGGAGGGGC
CTGCCAGCTTAGTGAGGGCCCCGTTGTCATGGAACTCATCTTTTATATTCTGGAAAACATCGTATAAACAGAGAAGACTTCATTTTTTTC
TGTTCAGACTTGTTGCAACAGCAGTCATACCCAAATCATTTGCACTTTAAAACTGGAAGATTAAGCTTTTGTTAACACTATTAATGGGGT
GGGGAATAGGGTGGGAGTGGGGGTTTGGGAGACGGGTGGGAAAGGGTGGTTGGGGGGACCGATGTTCCATAATTCTAAGTCTTCTATGCA
TTGTCCACCAAGAAGATCTGGGCAGCTTCTGTTCCTGCACAACAGTTATGCTATCCTTGCAGCTAATCCCCTTCTGTTACTGTTTAGACA
AGAATTCCGCTCCTCTCTCAAGATTTACTTATGGTCATGTGCTCAGAAATGCTCAAATGGGTACAACCATCACCAAGGGTGGGATGGGAG

>3058_3058_1_AHCYL1-ZFYVE9_AHCYL1_chr1_110527794_ENST00000369799_ZFYVE9_chr1_52798440_ENST00000287727_length(amino acids)=428AA_BP=149
MPVLDVASPPSTLALRACLRTAEVAARAGRSSELLFWFSCGRRRCPAALGCRTDKAWATAPQKPTQLDAGAGRRVGDRVSEGAARAGGRA
PEGERGGGGGSAAGRAGRGMSMPDAMPLPGVGEELKQAKEIEDAEKYSFMATVTKAPKKMMKAMNKSNEHVLAGGACFNEKADSHLVCVQ
NDDGNYQTQAISIHNQPRKVTGASFFVFSGALKSSSGYLAKSSIVEDGVMVQITAENMDSLRQALREMKDFTITCGKADAEEPQEHIHIQ
WVDDDKNVSKGVVSPIDGKSMETITNVKIFHGSEYKANGKVIRWTEVFFLENDDQHNCLSDPADHSRLTEHVAKAFCLALCPHLKLLKED

--------------------------------------------------------------
>3058_3058_2_AHCYL1-ZFYVE9_AHCYL1_chr1_110527794_ENST00000369799_ZFYVE9_chr1_52798440_ENST00000357206_length(transcript)=1621nt_BP=487nt
CAGAGTGCCCTTTCTCCCCGCCTCTTCCCCCTCCCGGGAGCTGCCAGTACTTGACGTGGCGTCACCGCCCTCTACCCTCGCTTTGCGTGC
GTGTTTGCGTACAGCGGAGGTGGCGGCGCGGGCAGGTCGGAGCTCGGAGCTGCTGTTCTGGTTCTCTTGTGGCCGCCGTCGCTGTCCGGC
TGCCTTGGGCTGCCGAACAGACAAGGCGTGGGCCACAGCACCTCAGAAGCCGACGCAGCTCGACGCAGGGGCCGGCAGGAGGGTGGGCGA
TCGCGTGTCGGAGGGCGCCGCGCGGGCAGGCGGGCGGGCGCCAGAGGGGGAAAGAGGCGGGGGCGGCGGGTCAGCCGCTGGCCGGGCCGG
CCGGGGAATGTCGATGCCTGACGCGATGCCGCTGCCCGGGGTCGGGGAGGAGCTGAAGCAGGCCAAGGAGATCGAGGACGCCGAGAAGTA
CTCCTTCATGGCCACCGTCACCAAGGCGCCCAAGAAGATGATGAAAGCCATGAACAAGTCCAATGAGCATGTCCTGGCAGGAGGTGCCTG
CTTCAATGAAAAGGCAGACTCTCATCTTGTGTGTGTACAGAATGATGATGGAAACTATCAGACCCAGGCTATCAGTATTCACAATCAGCC
CAGAAAAGTGACTGGTGCCAGTTTCTTTGTGTTCAGTGGCGCTCTGAAATCCTCTTCTGGATACCTTGCCAAGTCCAGTATTGTGGAAGA
TGGTGTTATGGTCCAGATTACTGCAGAGAACATGGATTCCTTGAGGCAGGCACTGCGAGAGATGAAGGACTTCACCATCACCTGTGGGAA
GGCGGACGCGGAGGAACCCCAGGAGCACATCCACATCCAGTGGGTGGATGATGACAAGAACGTTAGCAAGGGTGTCGTAAGTCCTATAGA
TGGGAAGTCCATGGAGACTATAACAAATGTGAAGATATTCCATGGATCAGAATATAAAGCAAATGGAAAAGTAATCAGATGGACAGAGGT
GTTTTTCCTAGAAAACGATGACCAGCACAATTGCCTCAGTGATCCTGCAGATCACAGTAGATTGACTGAGCATGTTGCCAAAGCTTTTTG
CCTTGCTCTCTGTCCTCACCTGAAACTTCTGAAGGAAGATGGAATGACCAAACTGGGACTACGTGTGACACTTGACTCAGATCAGGTTGG
CTATCAAGCAGGGAGCAATGGCCAGCCCCTTCCCTCGCAGTACATGAATGATCTGGACAGCGCCTTGGTGCCGGTGATCCATGGAGGGGC
CTGCCAGCTTAGTGAGGGCCCCGTTGTCATGGAACTCATCTTTTATATTCTGGAAAACATCGTATAAACAGAGAAGACTTCATTTTTTTC
TGTTCAGACTTGTTGCAACAGCAGTCATACCCAAATCATTTGCACTTTAAAACTGGAAGATTAAGCTTTTGTTAACACTATTAATGGGGT
GGGGAATAGGGTGGGAGTGGGGGTTTGGGAGACGGGTGGGAAAGGGTGGTTGGGGGGACCGATGTTCCATAATTCTAAGTCTTCTATGCA
TTGTCCACCAAGAAGATCTGGGCAGCTTCTGTTCCTGCACAACAGTTATGCTATCCTTGCAGCTAATCCCCTTCTGTTACTGTTTAGACA

>3058_3058_2_AHCYL1-ZFYVE9_AHCYL1_chr1_110527794_ENST00000369799_ZFYVE9_chr1_52798440_ENST00000357206_length(amino acids)=428AA_BP=149
MPVLDVASPPSTLALRACLRTAEVAARAGRSSELLFWFSCGRRRCPAALGCRTDKAWATAPQKPTQLDAGAGRRVGDRVSEGAARAGGRA
PEGERGGGGGSAAGRAGRGMSMPDAMPLPGVGEELKQAKEIEDAEKYSFMATVTKAPKKMMKAMNKSNEHVLAGGACFNEKADSHLVCVQ
NDDGNYQTQAISIHNQPRKVTGASFFVFSGALKSSSGYLAKSSIVEDGVMVQITAENMDSLRQALREMKDFTITCGKADAEEPQEHIHIQ
WVDDDKNVSKGVVSPIDGKSMETITNVKIFHGSEYKANGKVIRWTEVFFLENDDQHNCLSDPADHSRLTEHVAKAFCLALCPHLKLLKED

--------------------------------------------------------------
>3058_3058_3_AHCYL1-ZFYVE9_AHCYL1_chr1_110527794_ENST00000369799_ZFYVE9_chr1_52798440_ENST00000371591_length(transcript)=1792nt_BP=487nt
CAGAGTGCCCTTTCTCCCCGCCTCTTCCCCCTCCCGGGAGCTGCCAGTACTTGACGTGGCGTCACCGCCCTCTACCCTCGCTTTGCGTGC
GTGTTTGCGTACAGCGGAGGTGGCGGCGCGGGCAGGTCGGAGCTCGGAGCTGCTGTTCTGGTTCTCTTGTGGCCGCCGTCGCTGTCCGGC
TGCCTTGGGCTGCCGAACAGACAAGGCGTGGGCCACAGCACCTCAGAAGCCGACGCAGCTCGACGCAGGGGCCGGCAGGAGGGTGGGCGA
TCGCGTGTCGGAGGGCGCCGCGCGGGCAGGCGGGCGGGCGCCAGAGGGGGAAAGAGGCGGGGGCGGCGGGTCAGCCGCTGGCCGGGCCGG
CCGGGGAATGTCGATGCCTGACGCGATGCCGCTGCCCGGGGTCGGGGAGGAGCTGAAGCAGGCCAAGGAGATCGAGGACGCCGAGAAGTA
CTCCTTCATGGCCACCGTCACCAAGGCGCCCAAGAAGATGATGAAAGCCATGAACAAGTCCAATGAGCATGTCCTGGCAGGAGGTGCCTG
CTTCAATGAAAAGGCAGACTCTCATCTTGTGTGTGTACAGAATGATGATGGAAACTATCAGACCCAGGCTATCAGTATTCACAATCAGCC
CAGAAAAGTGACTGGTGCCAGTTTCTTTGTGTTCAGTGGCGCTCTGAAATCCTCTTCTGGATACCTTGCCAAGTCCAGTATTGTGGAAGA
TGGTGTTATGGTCCAGATTACTGCAGAGAACATGGATTCCTTGAGGCAGGCACTGCGAGAGATGAAGGACTTCACCATCACCTGTGGGAA
GGCGGACGCGGAGGAACCCCAGGAGCACATCCACATCCAGTGGGTGGATGATGACAAGAACGTTAGCAAGGGTGTCGTAAGTCCTATAGA
TGGGAAGTCCATGGAGACTATAACAAATGTGAAGATATTCCATGGATCAGAATATAAAGCAAATGGAAAAGTAATCAGATGGACAGAGGT
GTTTTTCCTAGAAAACGATGACCAGCACAATTGCCTCAGTGATCCTGCAGATCACAGTAGATTGACTGAGCATGTTGCCAAAGCTTTTTG
CCTTGCTCTCTGTCCTCACCTGAAACTTCTGAAGGAAGATGGAATGACCAAACTGGGACTACGTGTGACACTTGACTCAGATCAGGTTGG
CTATCAAGCAGGGAGCAATGGCCAGCCCCTTCCCTCGCAGTACATGAATGATCTGGACAGCGCCTTGGTGCCGGTGATCCATGGAGGGGC
CTGCCAGCTTAGTGAGGGCCCCGTTGTCATGGAACTCATCTTTTATATTCTGGAAAACATCGTATAAACAGAGAAGACTTCATTTTTTTC
TGTTCAGACTTGTTGCAACAGCAGTCATACCCAAATCATTTGCACTTTAAAACTGGAAGATTAAGCTTTTGTTAACACTATTAATGGGGT
GGGGAATAGGGTGGGAGTGGGGGTTTGGGAGACGGGTGGGAAAGGGTGGTTGGGGGGACCGATGTTCCATAATTCTAAGTCTTCTATGCA
TTGTCCACCAAGAAGATCTGGGCAGCTTCTGTTCCTGCACAACAGTTATGCTATCCTTGCAGCTAATCCCCTTCTGTTACTGTTTAGACA
AGAATTCCGCTCCTCTCTCAAGATTTACTTATGGTCATGTGCTCAGAAATGCTCAAATGGGTACAACCATCACCAAGGGTGGGATGGGAG

>3058_3058_3_AHCYL1-ZFYVE9_AHCYL1_chr1_110527794_ENST00000369799_ZFYVE9_chr1_52798440_ENST00000371591_length(amino acids)=428AA_BP=149
MPVLDVASPPSTLALRACLRTAEVAARAGRSSELLFWFSCGRRRCPAALGCRTDKAWATAPQKPTQLDAGAGRRVGDRVSEGAARAGGRA
PEGERGGGGGSAAGRAGRGMSMPDAMPLPGVGEELKQAKEIEDAEKYSFMATVTKAPKKMMKAMNKSNEHVLAGGACFNEKADSHLVCVQ
NDDGNYQTQAISIHNQPRKVTGASFFVFSGALKSSSGYLAKSSIVEDGVMVQITAENMDSLRQALREMKDFTITCGKADAEEPQEHIHIQ
WVDDDKNVSKGVVSPIDGKSMETITNVKIFHGSEYKANGKVIRWTEVFFLENDDQHNCLSDPADHSRLTEHVAKAFCLALCPHLKLLKED

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Fusion Gene PPI Analysis for AHCYL1-ZFYVE9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAHCYL1chr1:110527794chr1:52798440ENST00000359172+117138_2010484.0BCL2L10
HgeneAHCYL1chr1:110527794chr1:52798440ENST00000369799+117138_20140.0531.0BCL2L10
HgeneAHCYL1chr1:110527794chr1:52798440ENST00000393614+117138_2010484.0BCL2L10


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AHCYL1-ZFYVE9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AHCYL1-ZFYVE9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource