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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ARPP19-AATF (FusionGDB2 ID:HG10776TG26574) |
Fusion Gene Summary for ARPP19-AATF |
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Fusion gene information | Fusion gene name: ARPP19-AATF | Fusion gene ID: hg10776tg26574 | Hgene | Tgene | Gene symbol | ARPP19 | AATF | Gene ID | 10776 | 26574 |
Gene name | cAMP regulated phosphoprotein 19 | apoptosis antagonizing transcription factor | |
Synonyms | ARPP-16|ARPP-19|ARPP16|ENSAL | BFR2|CHE-1|CHE1|DED | |
Cytomap | ('ARPP19')('AATF') 15q21.2 | 17q12 | |
Type of gene | protein-coding | protein-coding | |
Description | cAMP-regulated phosphoprotein 19cAMP-regulated phosphoprotein 19kDacyclic AMP phosphoprotein, 19 kD | protein AATFrb-binding protein Che-1 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | P56211 | . | |
Ensembl transtripts involved in fusion gene | ENST00000249822, ENST00000561971, ENST00000564163, ENST00000566423, ENST00000567669, ENST00000569281, ENST00000569723, ENST00000561650, ENST00000563277, ENST00000563566, ENST00000565288, ENST00000568196, | ||
Fusion gene scores | * DoF score | 2 X 2 X 3=12 | 26 X 13 X 11=3718 |
# samples | 3 | 28 | |
** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(28/3718*10)=-3.73102803797452 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ARPP19 [Title/Abstract] AND AATF [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ARPP19(52861044)-AATF(35376303), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | ARPP19-AATF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARPP19-AATF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ARPP19 | GO:0045722 | positive regulation of gluconeogenesis | 9653196 |
Tgene | AATF | GO:0032929 | negative regulation of superoxide anion generation | 15207272 |
Tgene | AATF | GO:0045944 | positive regulation of transcription by RNA polymerase II | 18049476 |
Tgene | AATF | GO:2000378 | negative regulation of reactive oxygen species metabolic process | 15207272 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-KB-A93J | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
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Fusion Gene ORF analysis for ARPP19-AATF |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000249822 | ENST00000590321 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
5CDS-intron | ENST00000561971 | ENST00000590321 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
5CDS-intron | ENST00000564163 | ENST00000590321 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
5CDS-intron | ENST00000566423 | ENST00000590321 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
5CDS-intron | ENST00000567669 | ENST00000590321 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
5CDS-intron | ENST00000569281 | ENST00000590321 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
5CDS-intron | ENST00000569723 | ENST00000590321 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
Frame-shift | ENST00000561971 | ENST00000225402 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
Frame-shift | ENST00000567669 | ENST00000225402 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
Frame-shift | ENST00000569281 | ENST00000225402 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
In-frame | ENST00000249822 | ENST00000225402 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
In-frame | ENST00000564163 | ENST00000225402 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
In-frame | ENST00000566423 | ENST00000225402 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
In-frame | ENST00000569723 | ENST00000225402 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
intron-3CDS | ENST00000561650 | ENST00000225402 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
intron-3CDS | ENST00000563277 | ENST00000225402 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
intron-3CDS | ENST00000563566 | ENST00000225402 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
intron-3CDS | ENST00000565288 | ENST00000225402 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
intron-3CDS | ENST00000568196 | ENST00000225402 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
intron-intron | ENST00000561650 | ENST00000590321 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
intron-intron | ENST00000563277 | ENST00000590321 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
intron-intron | ENST00000563566 | ENST00000590321 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
intron-intron | ENST00000565288 | ENST00000590321 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
intron-intron | ENST00000568196 | ENST00000590321 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000566423 | ARPP19 | chr15 | 52861044 | - | ENST00000225402 | AATF | chr17 | 35376303 | + | 671 | 179 | 134 | 463 | 109 |
ENST00000249822 | ARPP19 | chr15 | 52861044 | - | ENST00000225402 | AATF | chr17 | 35376303 | + | 809 | 317 | 182 | 601 | 139 |
ENST00000569723 | ARPP19 | chr15 | 52861044 | - | ENST00000225402 | AATF | chr17 | 35376303 | + | 586 | 94 | 49 | 378 | 109 |
ENST00000564163 | ARPP19 | chr15 | 52861044 | - | ENST00000225402 | AATF | chr17 | 35376303 | + | 660 | 168 | 33 | 452 | 139 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000566423 | ENST00000225402 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + | 0.019869367 | 0.9801307 |
ENST00000249822 | ENST00000225402 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + | 0.023068419 | 0.97693163 |
ENST00000569723 | ENST00000225402 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + | 0.016195128 | 0.9838049 |
ENST00000564163 | ENST00000225402 | ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + | 0.019887548 | 0.98011243 |
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Fusion Genomic Features for ARPP19-AATF |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + | 5.78E-10 | 1 |
ARPP19 | chr15 | 52861044 | - | AATF | chr17 | 35376303 | + | 5.78E-10 | 1 |
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Fusion Protein Features for ARPP19-AATF |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:52861044/chr17:35376303) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
ARPP19 | . |
FUNCTION: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. {ECO:0000269|PubMed:21164014}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | AATF | chr15:52861044 | chr17:35376303 | ENST00000225402 | 7 | 12 | 96_195 | 466 | 561.0 | Compositional bias | Note=Glu-rich | |
Tgene | AATF | chr15:52861044 | chr17:35376303 | ENST00000225402 | 7 | 12 | 273_315 | 466 | 561.0 | Region | Note=POLR2J binding | |
Tgene | AATF | chr15:52861044 | chr17:35376303 | ENST00000225402 | 7 | 12 | 316_372 | 466 | 561.0 | Region | Note=RB1 binding | |
Tgene | AATF | chr15:52861044 | chr17:35376303 | ENST00000225402 | 7 | 12 | 373_472 | 466 | 561.0 | Region | Note=RB1 and SP1 binding |
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Fusion Gene Sequence for ARPP19-AATF |
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>6826_6826_1_ARPP19-AATF_ARPP19_chr15_52861044_ENST00000249822_AATF_chr17_35376303_ENST00000225402_length(transcript)=809nt_BP=317nt GGAAAAAAGGAAGTGTTTGGACGACAGCGAGCGGGAGAAGCGGGGTCAAGTAGGTAGGGGTGCGGTGCGGGAGGGGCAGGCGGGCTCCGG CGTGCGAGGGCCTTGGCCAGCGGAGCGTTTCGCGGCTCCGTGTCGTCATAAGGCGGCGGCCATTTTCGCGGGCGGAGGCGGCCCGGCGGG CCCTGGGAGAGCTGGGACGGGCGGCGGCCGGGTGGCCTCGGCCACCCGCTAATTGCATCTTTTCCCGGCGTCTCGTCTGCAGAGGGAGCA CTATGTCTGCGGAAGTCCCCGAGGCAGCCTCCGCGGAGGAGCAGAAGCTCCTTCGAGAACTCATAGAACGGAAGACCAGCTCCTTGGATC CCAACGATCAGGTGGCCATGGGAAGGCAGTGGCTTGCAATCCAGAAGTTACGAAGCAAAATCCACAAAAAAGTAGATAGGAAAGCCAGCA AAGGCAGGAAACTTCGGTTTCATGTCCTTAGCAAGCTACTGAGTTTCATGGCACCTATTGACCATACTACAATGAATGATGATGCCAGGA CAGAACTGTACCGCTCTCTTTTTGGCCAGCTCCACCCTCCCGACGAAGGCCACGGGGATTGACATCGCCCACCTCCGACACCCAGTGGGC GCCTTGGCTGGTGCGGCTGCTGGTCCAGATGGAGGAAACCAGTGACTTTATGGGGCTGAGCTAGTAGGGAAGCCCCTGGAAAGATGCTGC >6826_6826_1_ARPP19-AATF_ARPP19_chr15_52861044_ENST00000249822_AATF_chr17_35376303_ENST00000225402_length(amino acids)=139AA_BP=45 MGELGRAAAGWPRPPANCIFSRRLVCRGSTMSAEVPEAASAEEQKLLRELIERKTSSLDPNDQVAMGRQWLAIQKLRSKIHKKVDRKASK -------------------------------------------------------------- >6826_6826_2_ARPP19-AATF_ARPP19_chr15_52861044_ENST00000564163_AATF_chr17_35376303_ENST00000225402_length(transcript)=660nt_BP=168nt CCATTTTCGCGGGCGGAGGCGGCCCGGCGGGCCCTGGGAGAGCTGGGACGGGCGGCGGCCGGGTGGCCTCGGCCACCCGCTAATTGCATC TTTTCCCGGCGTCTCGTCTGCAGAGGGAGCACTATGTCTGCGGAAGTCCCCGAGGCAGCCTCCGCGGAGGAGCAGAAGCTCCTTCGAGAA CTCATAGAACGGAAGACCAGCTCCTTGGATCCCAACGATCAGGTGGCCATGGGAAGGCAGTGGCTTGCAATCCAGAAGTTACGAAGCAAA ATCCACAAAAAAGTAGATAGGAAAGCCAGCAAAGGCAGGAAACTTCGGTTTCATGTCCTTAGCAAGCTACTGAGTTTCATGGCACCTATT GACCATACTACAATGAATGATGATGCCAGGACAGAACTGTACCGCTCTCTTTTTGGCCAGCTCCACCCTCCCGACGAAGGCCACGGGGAT TGACATCGCCCACCTCCGACACCCAGTGGGCGCCTTGGCTGGTGCGGCTGCTGGTCCAGATGGAGGAAACCAGTGACTTTATGGGGCTGA GCTAGTAGGGAAGCCCCTGGAAAGATGCTGCGTTCCGAACCTGTGCCTAATACACGCAAGGGCGCTGTCCCGCCCAACCCCGCCTTTAAA >6826_6826_2_ARPP19-AATF_ARPP19_chr15_52861044_ENST00000564163_AATF_chr17_35376303_ENST00000225402_length(amino acids)=139AA_BP=45 MGELGRAAAGWPRPPANCIFSRRLVCRGSTMSAEVPEAASAEEQKLLRELIERKTSSLDPNDQVAMGRQWLAIQKLRSKIHKKVDRKASK -------------------------------------------------------------- >6826_6826_3_ARPP19-AATF_ARPP19_chr15_52861044_ENST00000566423_AATF_chr17_35376303_ENST00000225402_length(transcript)=671nt_BP=179nt AGAAACTACAATTCCCAGGAAGCACTCGGCAGCCACAAACGGATGTGAGGTGAGGCAGGAGCGGCGACCTTTGAAGGAAAAAAGGAAGTG TTTGGACGACAGCGAGCGGGAGAAGCGGGGTCAAAGGGAGCACTATGTCTGCGGAAGTCCCCGAGGCAGCCTCCGCGGAGGAGCAGAAGC TCCTTCGAGAACTCATAGAACGGAAGACCAGCTCCTTGGATCCCAACGATCAGGTGGCCATGGGAAGGCAGTGGCTTGCAATCCAGAAGT TACGAAGCAAAATCCACAAAAAAGTAGATAGGAAAGCCAGCAAAGGCAGGAAACTTCGGTTTCATGTCCTTAGCAAGCTACTGAGTTTCA TGGCACCTATTGACCATACTACAATGAATGATGATGCCAGGACAGAACTGTACCGCTCTCTTTTTGGCCAGCTCCACCCTCCCGACGAAG GCCACGGGGATTGACATCGCCCACCTCCGACACCCAGTGGGCGCCTTGGCTGGTGCGGCTGCTGGTCCAGATGGAGGAAACCAGTGACTT TATGGGGCTGAGCTAGTAGGGAAGCCCCTGGAAAGATGCTGCGTTCCGAACCTGTGCCTAATACACGCAAGGGCGCTGTCCCGCCCAACC >6826_6826_3_ARPP19-AATF_ARPP19_chr15_52861044_ENST00000566423_AATF_chr17_35376303_ENST00000225402_length(amino acids)=109AA_BP=15 MSAEVPEAASAEEQKLLRELIERKTSSLDPNDQVAMGRQWLAIQKLRSKIHKKVDRKASKGRKLRFHVLSKLLSFMAPIDHTTMNDDART -------------------------------------------------------------- >6826_6826_4_ARPP19-AATF_ARPP19_chr15_52861044_ENST00000569723_AATF_chr17_35376303_ENST00000225402_length(transcript)=586nt_BP=94nt AAGTGTTTGGACGACAGCGAGCGGGAGAAGCGGGGTCAAAGGGAGCACTATGTCTGCGGAAGTCCCCGAGGCAGCCTCCGCGGAGGAGCA GAAGCTCCTTCGAGAACTCATAGAACGGAAGACCAGCTCCTTGGATCCCAACGATCAGGTGGCCATGGGAAGGCAGTGGCTTGCAATCCA GAAGTTACGAAGCAAAATCCACAAAAAAGTAGATAGGAAAGCCAGCAAAGGCAGGAAACTTCGGTTTCATGTCCTTAGCAAGCTACTGAG TTTCATGGCACCTATTGACCATACTACAATGAATGATGATGCCAGGACAGAACTGTACCGCTCTCTTTTTGGCCAGCTCCACCCTCCCGA CGAAGGCCACGGGGATTGACATCGCCCACCTCCGACACCCAGTGGGCGCCTTGGCTGGTGCGGCTGCTGGTCCAGATGGAGGAAACCAGT GACTTTATGGGGCTGAGCTAGTAGGGAAGCCCCTGGAAAGATGCTGCGTTCCGAACCTGTGCCTAATACACGCAAGGGCGCTGTCCCGCC >6826_6826_4_ARPP19-AATF_ARPP19_chr15_52861044_ENST00000569723_AATF_chr17_35376303_ENST00000225402_length(amino acids)=109AA_BP=15 MSAEVPEAASAEEQKLLRELIERKTSSLDPNDQVAMGRQWLAIQKLRSKIHKKVDRKASKGRKLRFHVLSKLLSFMAPIDHTTMNDDART -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ARPP19-AATF |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ARPP19-AATF |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ARPP19-AATF |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |