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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ADCY1-JUN (FusionGDB2 ID:HG107TG3725) |
Fusion Gene Summary for ADCY1-JUN |
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Fusion gene information | Fusion gene name: ADCY1-JUN | Fusion gene ID: hg107tg3725 | Hgene | Tgene | Gene symbol | ADCY1 | JUN | Gene ID | 107 | 3725 |
Gene name | adenylate cyclase 1 | Jun proto-oncogene, AP-1 transcription factor subunit | |
Synonyms | AC1|DFNB44 | AP-1|AP1|c-Jun|cJUN|p39 | |
Cytomap | ('ADCY1')('JUN') 7p12.3 | 1p32.1 | |
Type of gene | protein-coding | protein-coding | |
Description | adenylate cyclase type 13',5'-cyclic AMP synthetaseATP pyrophosphate-lyase 1Ca(2+)/calmodulin-activated adenylyl cyclaseadenyl cyclaseadenylate cyclase 1 (brain)adenylate cyclase type Iadenylyl cyclase 1 | transcription factor AP-1Jun activation domain binding proteinactivator protein 1enhancer-binding protein AP1jun oncogeneproto-oncogene c-Junproto-oncogene cJunv-jun avian sarcoma virus 17 oncogene homologv-jun sarcoma virus 17 oncogene homolog | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q08828 | P05412 | |
Ensembl transtripts involved in fusion gene | ENST00000297323, ENST00000432715, | ||
Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 6 X 6 X 2=72 |
# samples | 5 | 6 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ADCY1 [Title/Abstract] AND JUN [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ADCY1(45761756)-JUN(59248643), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | JUN | GO:0007179 | transforming growth factor beta receptor signaling pathway | 9732876 |
Tgene | JUN | GO:0007265 | Ras protein signal transduction | 24623306 |
Tgene | JUN | GO:0043392 | negative regulation of DNA binding | 14645924 |
Tgene | JUN | GO:0043922 | negative regulation by host of viral transcription | 2833704 |
Tgene | JUN | GO:0043923 | positive regulation by host of viral transcription | 2833704 |
Tgene | JUN | GO:0045892 | negative regulation of transcription, DNA-templated | 2833704 |
Tgene | JUN | GO:0045893 | positive regulation of transcription, DNA-templated | 2833704|9732876|22083952 |
Tgene | JUN | GO:0045944 | positive regulation of transcription by RNA polymerase II | 2833704|10508860|12490281|19861239 |
Tgene | JUN | GO:0060395 | SMAD protein signal transduction | 9732876 |
Tgene | JUN | GO:2000144 | positive regulation of DNA-templated transcription, initiation | 23027619 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for ADCY1-JUN |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ADCY1-JUN |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ADCY1-JUN |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:45761756/:59248643) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
ADCY1 | JUN |
FUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity). {ECO:0000250|UniProtKB:O88444, ECO:0000250|UniProtKB:P19754}. | FUNCTION: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3' (PubMed:10995748, PubMed:22083952). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). {ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24623306}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ADCY1-JUN |
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Fusion Gene PPI Analysis for ADCY1-JUN |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ADCY1-JUN |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | ADCY1 | Q08828 | DB00131 | Adenosine phosphate | Product of | Small molecule | Approved|Investigational|Nutraceutical |
Hgene | ADCY1 | Q08828 | DB09121 | Aurothioglucose | Small molecule | Approved|Withdrawn | |
Tgene | JUN | P05412 | DB00210 | Adapalene | Antagonist | Small molecule | Approved |
Tgene | JUN | P05412 | DB00570 | Vinblastine | Other/unknown | Small molecule | Approved |
Tgene | JUN | P05412 | DB01029 | Irbesartan | Other/unknown | Small molecule | Approved|Investigational |
Tgene | JUN | P05412 | DB01169 | Arsenic trioxide | Inducer | Small molecule | Approved|Investigational |
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Related Diseases for ADCY1-JUN |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ADCY1 | C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human |
Hgene | ADCY1 | C0086189 | Drug Withdrawal Symptoms | 1 | CTD_human |
Hgene | ADCY1 | C0087169 | Withdrawal Symptoms | 1 | CTD_human |
Hgene | ADCY1 | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
Hgene | ADCY1 | C0751217 | Hyperkinesia, Generalized | 1 | CTD_human |
Hgene | ADCY1 | C1846647 | DEAFNESS, AUTOSOMAL RECESSIVE (disorder) | 1 | CLINGEN |
Hgene | ADCY1 | C3887506 | Hyperkinesia | 1 | CTD_human |
Tgene | C0007102 | Malignant tumor of colon | 2 | CTD_human | |
Tgene | C0007621 | Neoplastic Cell Transformation | 2 | CTD_human | |
Tgene | C0009375 | Colonic Neoplasms | 2 | CTD_human | |
Tgene | C0023903 | Liver neoplasms | 2 | CTD_human | |
Tgene | C0036341 | Schizophrenia | 2 | PSYGENET | |
Tgene | C0345904 | Malignant neoplasm of liver | 2 | CTD_human | |
Tgene | C0005398 | Cholestasis, Extrahepatic | 1 | CTD_human | |
Tgene | C0006142 | Malignant neoplasm of breast | 1 | CTD_human | |
Tgene | C0007786 | Brain Ischemia | 1 | CTD_human | |
Tgene | C0018923 | Hemangiosarcoma | 1 | CTD_human | |
Tgene | C0020538 | Hypertensive disease | 1 | CTD_human | |
Tgene | C0021846 | Intestinal Polyps | 1 | CTD_human | |
Tgene | C0024121 | Lung Neoplasms | 1 | CTD_human | |
Tgene | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human | |
Tgene | C0029463 | Osteosarcoma | 1 | CTD_human | |
Tgene | C0035126 | Reperfusion Injury | 1 | CTD_human | |
Tgene | C0037116 | Silicosis | 1 | CTD_human | |
Tgene | C0038220 | Status Epilepticus | 1 | CTD_human | |
Tgene | C0038356 | Stomach Neoplasms | 1 | CTD_human | |
Tgene | C0086626 | Minamata Disease | 1 | CTD_human | |
Tgene | C0087031 | Juvenile-Onset Still Disease | 1 | CTD_human | |
Tgene | C0242379 | Malignant neoplasm of lung | 1 | CTD_human | |
Tgene | C0270823 | Petit mal status | 1 | CTD_human | |
Tgene | C0274859 | Inorganic Mercury Poisoning | 1 | CTD_human | |
Tgene | C0274860 | Mercury Poisoning, Organic | 1 | CTD_human | |
Tgene | C0311335 | Grand Mal Status Epilepticus | 1 | CTD_human | |
Tgene | C0393734 | Complex Partial Status Epilepticus | 1 | CTD_human | |
Tgene | C0546127 | Mercury Poisoning, Nervous System | 1 | CTD_human | |
Tgene | C0678222 | Breast Carcinoma | 1 | CTD_human | |
Tgene | C0751522 | Status Epilepticus, Subclinical | 1 | CTD_human | |
Tgene | C0751523 | Non-Convulsive Status Epilepticus | 1 | CTD_human | |
Tgene | C0751524 | Simple Partial Status Epilepticus | 1 | CTD_human | |
Tgene | C0751855 | Mercury Encephalopathy | 1 | CTD_human | |
Tgene | C0751856 | Mad Hatter Disease | 1 | CTD_human | |
Tgene | C0751857 | Mercurial Neuroanesthenia | 1 | CTD_human | |
Tgene | C0751858 | Mercury Psychosis | 1 | CTD_human | |
Tgene | C0917798 | Cerebral Ischemia | 1 | CTD_human | |
Tgene | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human | |
Tgene | C1458155 | Mammary Neoplasms | 1 | CTD_human | |
Tgene | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human | |
Tgene | C2239176 | Liver carcinoma | 1 | CTD_human | |
Tgene | C3495559 | Juvenile arthritis | 1 | CTD_human | |
Tgene | C3714758 | Juvenile psoriatic arthritis | 1 | CTD_human | |
Tgene | C4552091 | Polyarthritis, Juvenile, Rheumatoid Factor Negative | 1 | CTD_human | |
Tgene | C4704862 | Polyarthritis, Juvenile, Rheumatoid Factor Positive | 1 | CTD_human | |
Tgene | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human | |
Tgene | C4721453 | Peripheral Nervous System Diseases | 1 | CTD_human |