Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:FRS2-LACRT (FusionGDB2 ID:HG10818TG90070)

Fusion Gene Summary for FRS2-LACRT

check button Fusion gene summary
Fusion gene informationFusion gene name: FRS2-LACRT
Fusion gene ID: hg10818tg90070
HgeneTgene
Gene symbol

FRS2

LACRT

Gene ID

10818

90070

Gene namefibroblast growth factor receptor substrate 2lacritin
SynonymsFRS1A|FRS2A|FRS2alpha|SNT|SNT-1|SNT1-
Cytomap('FRS2')('LACRT')

12q15

12q13.2

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor substrate 2FGFR signalling adaptorFGFR substrate 2FGFR-signaling adaptor SNTepididymis secretory sperm binding proteinsuc1-associated neurotrophic factor target 1extracellular glycoprotein lacritin
Modification date2020031320200313
UniProtAcc

Q8WU20

Q9GZZ8

Ensembl transtripts involved in fusion geneENST00000299293, ENST00000549921, 
ENST00000550389, ENST00000397997, 
Fusion gene scores* DoF score71 X 15 X 14=149102 X 1 X 2=4
# samples 732
** MAII scorelog2(73/14910*10)=-4.35223998340343
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: FRS2 [Title/Abstract] AND LACRT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFRS2(69864310)-LACRT(55027017), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLACRT

GO:0008284

positive regulation of cell proliferation

11419941|16982797

TgeneLACRT

GO:0010669

epithelial structure maintenance

25034600

TgeneLACRT

GO:0016239

positive regulation of macroautophagy

23640897

TgeneLACRT

GO:0019722

calcium-mediated signaling

11419941|16923831

TgeneLACRT

GO:0031665

negative regulation of lipopolysaccharide-mediated signaling pathway

26670139

TgeneLACRT

GO:0033173

calcineurin-NFAT signaling cascade

16923831

TgeneLACRT

GO:0034067

protein localization to Golgi apparatus

16923831

TgeneLACRT

GO:0042742

defense response to bacterium

24942736

TgeneLACRT

GO:0043066

negative regulation of apoptotic process

26670139

TgeneLACRT

GO:0050679

positive regulation of epithelial cell proliferation

16923831

TgeneLACRT

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

11419941

TgeneLACRT

GO:0050850

positive regulation of calcium-mediated signaling

25530855

TgeneLACRT

GO:0051047

positive regulation of secretion

11419941

TgeneLACRT

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

16923831

TgeneLACRT

GO:0060054

positive regulation of epithelial cell proliferation involved in wound healing

25530855

TgeneLACRT

GO:0070075

tear secretion

25034600|25481446

TgeneLACRT

GO:0070886

positive regulation of calcineurin-NFAT signaling cascade

16923831



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-S5-A6DX-01AFRS2chr12

69864310

-LACRTchr12

55027017

-
ChimerDB4BLCATCGA-S5-A6DX-01AFRS2chr12

69864310

+LACRTchr12

55027017

-


Top

Fusion Gene ORF analysis for FRS2-LACRT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000299293ENST00000257867FRS2chr12

69864310

+LACRTchr12

55027017

-
5UTR-3CDSENST00000299293ENST00000547511FRS2chr12

69864310

+LACRTchr12

55027017

-
5UTR-3CDSENST00000549921ENST00000257867FRS2chr12

69864310

+LACRTchr12

55027017

-
5UTR-3CDSENST00000549921ENST00000547511FRS2chr12

69864310

+LACRTchr12

55027017

-
5UTR-3CDSENST00000550389ENST00000257867FRS2chr12

69864310

+LACRTchr12

55027017

-
5UTR-3CDSENST00000550389ENST00000547511FRS2chr12

69864310

+LACRTchr12

55027017

-
intron-3CDSENST00000397997ENST00000257867FRS2chr12

69864310

+LACRTchr12

55027017

-
intron-3CDSENST00000397997ENST00000547511FRS2chr12

69864310

+LACRTchr12

55027017

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for FRS2-LACRT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


Top

Fusion Protein Features for FRS2-LACRT


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:69864310/:55027017)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FRS2

Q8WU20

LACRT

Q9GZZ8

FUNCTION: Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:21765395}.FUNCTION: Modulates secretion by lacrimal acinar cells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for FRS2-LACRT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for FRS2-LACRT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for FRS2-LACRT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for FRS2-LACRT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource