Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ARID5A-CNNM4 (FusionGDB2 ID:HG10865TG26504)

Fusion Gene Summary for ARID5A-CNNM4

check button Fusion gene summary
Fusion gene informationFusion gene name: ARID5A-CNNM4
Fusion gene ID: hg10865tg26504
HgeneTgene
Gene symbol

ARID5A

CNNM4

Gene ID

10865

26504

Gene nameAT-rich interaction domain 5Acyclin and CBS domain divalent metal cation transport mediator 4
SynonymsMRF-1|MRF1|RP11-363D14ACDP4
Cytomap('ARID5A')('CNNM4')

2q11.2

2q11.2

Type of geneprotein-codingprotein-coding
DescriptionAT-rich interactive domain-containing protein 5AARID domain-containing protein 5AAT rich interactive domain 5A (MRF1-like)RFVG5814modulator recognition factor 1modulator recognition factor Imetal transporter CNNM4ancient conserved domain protein 4ancient conserved domain-containing protein 4cyclin-M4
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000357485, ENST00000454558, 
Fusion gene scores* DoF score4 X 3 X 3=364 X 5 X 2=40
# samples 45
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARID5A [Title/Abstract] AND CNNM4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARID5A(97202567)-CNNM4(97462749), # samples:2
Anticipated loss of major functional domain due to fusion event.ARID5A-CNNM4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID5A-CNNM4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARID5A

GO:0000122

negative regulation of transcription by RNA polymerase II

15941852

HgeneARID5A

GO:0071391

cellular response to estrogen stimulus

15941852

TgeneCNNM4

GO:0055065

metal ion homeostasis

15840172


check buttonFusion gene breakpoints across ARID5A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CNNM4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AM-5820-01AARID5Achr2

97202567

+CNNM4chr2

97462749

+
ChimerDB4COADTCGA-AM-5820ARID5Achr2

97202567

+CNNM4chr2

97462748

+


Top

Fusion Gene ORF analysis for ARID5A-CNNM4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000357485ENST00000496186ARID5Achr2

97202567

+CNNM4chr2

97462749

+
5CDS-3UTRENST00000357485ENST00000496186ARID5Achr2

97202567

+CNNM4chr2

97462748

+
5CDS-5UTRENST00000357485ENST00000540067ARID5Achr2

97202567

+CNNM4chr2

97462749

+
5CDS-5UTRENST00000357485ENST00000540067ARID5Achr2

97202567

+CNNM4chr2

97462748

+
In-frameENST00000357485ENST00000377075ARID5Achr2

97202567

+CNNM4chr2

97462749

+
In-frameENST00000357485ENST00000377075ARID5Achr2

97202567

+CNNM4chr2

97462748

+
intron-3CDSENST00000454558ENST00000377075ARID5Achr2

97202567

+CNNM4chr2

97462749

+
intron-3CDSENST00000454558ENST00000377075ARID5Achr2

97202567

+CNNM4chr2

97462748

+
intron-3UTRENST00000454558ENST00000496186ARID5Achr2

97202567

+CNNM4chr2

97462749

+
intron-3UTRENST00000454558ENST00000496186ARID5Achr2

97202567

+CNNM4chr2

97462748

+
intron-5UTRENST00000454558ENST00000540067ARID5Achr2

97202567

+CNNM4chr2

97462749

+
intron-5UTRENST00000454558ENST00000540067ARID5Achr2

97202567

+CNNM4chr2

97462748

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000357485ARID5Achr297202567+ENST00000377075CNNM4chr297462749+338282781007309
ENST00000357485ARID5Achr297202567+ENST00000377075CNNM4chr297462748+338282781007309

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357485ENST00000377075ARID5Achr297202567+CNNM4chr297462749+0.0028484390.99715155
ENST00000357485ENST00000377075ARID5Achr297202567+CNNM4chr297462748+0.0028484390.99715155

Top

Fusion Genomic Features for ARID5A-CNNM4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARID5Achr297202567+CNNM4chr297462748+2.84E-060.99999714
ARID5Achr297202567+CNNM4chr297462748+2.84E-060.99999714
ARID5Achr297202567+CNNM4chr297462748+2.84E-060.99999714
ARID5Achr297202567+CNNM4chr297462748+2.84E-060.99999714

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ARID5A-CNNM4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:97202567/chr2:97462749)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARID5Achr2:97202567chr2:97462748ENST00000357485+1755_1471595.0DomainARID
HgeneARID5Achr2:97202567chr2:97462749ENST00000357485+1755_1471595.0DomainARID
TgeneCNNM4chr2:97202567chr2:97462748ENST0000037707507178_358467776.0DomainCNNM transmembrane
TgeneCNNM4chr2:97202567chr2:97462748ENST0000037707507377_438467776.0DomainCBS 1
TgeneCNNM4chr2:97202567chr2:97462748ENST0000037707507445_511467776.0DomainCBS 2
TgeneCNNM4chr2:97202567chr2:97462749ENST0000037707507178_358467776.0DomainCNNM transmembrane
TgeneCNNM4chr2:97202567chr2:97462749ENST0000037707507377_438467776.0DomainCBS 1
TgeneCNNM4chr2:97202567chr2:97462749ENST0000037707507445_511467776.0DomainCBS 2
TgeneCNNM4chr2:97202567chr2:97462748ENST0000037707507241_261467776.0IntramembraneHelical
TgeneCNNM4chr2:97202567chr2:97462749ENST0000037707507241_261467776.0IntramembraneHelical
TgeneCNNM4chr2:97202567chr2:97462748ENST00000377075071_178467776.0Topological domainExtracellular
TgeneCNNM4chr2:97202567chr2:97462748ENST0000037707507200_240467776.0Topological domainCytoplasmic
TgeneCNNM4chr2:97202567chr2:97462748ENST0000037707507262_264467776.0Topological domainCytoplasmic
TgeneCNNM4chr2:97202567chr2:97462748ENST0000037707507286_293467776.0Topological domainExtracellular
TgeneCNNM4chr2:97202567chr2:97462748ENST0000037707507317_775467776.0Topological domainCytoplasmic
TgeneCNNM4chr2:97202567chr2:97462749ENST00000377075071_178467776.0Topological domainExtracellular
TgeneCNNM4chr2:97202567chr2:97462749ENST0000037707507200_240467776.0Topological domainCytoplasmic
TgeneCNNM4chr2:97202567chr2:97462749ENST0000037707507262_264467776.0Topological domainCytoplasmic
TgeneCNNM4chr2:97202567chr2:97462749ENST0000037707507286_293467776.0Topological domainExtracellular
TgeneCNNM4chr2:97202567chr2:97462749ENST0000037707507317_775467776.0Topological domainCytoplasmic
TgeneCNNM4chr2:97202567chr2:97462748ENST0000037707507179_199467776.0TransmembraneHelical
TgeneCNNM4chr2:97202567chr2:97462748ENST0000037707507265_285467776.0TransmembraneHelical
TgeneCNNM4chr2:97202567chr2:97462748ENST0000037707507294_316467776.0TransmembraneHelical
TgeneCNNM4chr2:97202567chr2:97462749ENST0000037707507179_199467776.0TransmembraneHelical
TgeneCNNM4chr2:97202567chr2:97462749ENST0000037707507265_285467776.0TransmembraneHelical
TgeneCNNM4chr2:97202567chr2:97462749ENST0000037707507294_316467776.0TransmembraneHelical


Top

Fusion Gene Sequence for ARID5A-CNNM4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6492_6492_1_ARID5A-CNNM4_ARID5A_chr2_97202567_ENST00000357485_CNNM4_chr2_97462748_ENST00000377075_length(transcript)=3382nt_BP=82nt
AGTATCTCAGAGAGCGCGGGGTCCGGACAGCCGCGCGCTGAGGGTCTCGGGGCGGGCGCCGCGGGACCTCTCCGGGCCATGGGGAAGTCC
CACCTGGCCATCGTGCAGAAGGTAAACAACGAGGGTGAGGGTGACCCCTTCTACGAGGTCCTGGGCCTGGTCACCCTGGAGGACGTGATC
GAGGAGATCATCAAGTCGGAGATCCTGGACGAGTCCGACATGTACACTGACAACCGAAGCCGGAAGCGGGTGTCTGAGAAGAACAAGCGT
GACTTCTCTGCCTTCAAGGATGCGGACAATGAGCTCAAAGTGAAAATCTCCCCGCAGCTCCTCCTGGCCGCTCATCGCTTCCTAGCCACA
GAGGTCTCTCAGTTTAGCCCCTCCCTGATATCAGAGAAGATCCTGCTGCGGCTACTCAAGTACCCAGATGTCATTCAGGAACTCAAGTTT
GACGAGCACAATAAGTACTACGCCCGCCATTACCTGTACACCCGAAATAAGCCGGCCGACTACTTCATCCTCATCCTGCAGGGGAAGGTG
GAGGTGGAGGCAGGGAAGGAGAACATGAAGTTTGAGACGGGCGCCTTCTCCTACTATGGGACTATGGCCCTGACCTCGGTCCCCTCCGAC
CGTTCCCCAGCACACCCCACCCCACTCAGCCGCTCAGCCTCCCTCAGTTACCCAGACCGCACAGACGTCTCAACTGCAGCAACCTTGGCA
GGCAGCAGCAACCAGTTTGGCAGCTCTGTCCTGGGCCAGTACATCTCTGACTTCAGCGTCCGGGCACTCGTGGACTTGCAGTACATCAAG
ATCACTCGGCAGCAGTACCAGAACGGGCTGCTGGCTTCTCGCATGGAGAACAGCCCTCAGTTTCCCATAGACGGGTGCACCACCCACATG
GAGAACTTGGCCGAGAAGTCTGAGCTGCCTGTGGTGGACGAGACCACAACTCTTCTCAACGAGCGTAACTCCTTGCTGCACAAAGCCTCC
CACGAGAATGCCATCTGACAGGAGGGCCCGGGGCCCCCTGCCCACCCTGCGGGGGCCTCCCCAGTGGGCCCACATGAAGAGAGGGAACCT
GTTAGTCCAGAAAGGATACGGATAGATAGCCTGTCTGACTGAACAGCCAGATGGCCCCCAGCCTATGGGGGATCTGGCCTCTGCCAGGGA
CCTCTGAGTAGCTCTGAGGTGGCACTGTCCAGCCCTGGATAGGGGGGGCAGTGGGCCAGCTACCGTAAGCAAAGGCTGTTTTTTACTGAG
AGAATTTCTAAAGTAGGCTCATCACTTTTTTTTAAATATCATTTTGGGAAGGGAAGACAGGGTTAAGGAACTTTATTTAAAAAAAAAATA
TTTTTTTCCTAAAAACTATAAAAGAGGAAGGGTTTCTTGTCCCGGGAAGCAACGGACATAATCTGTTCCCAGCCATGGCCTTCCAGCTTG
TGTCCCTGATTCAGGGAGCTCTCCCTTCCTCCTCCTCCTCCTCCTCCGGAGGTGGGATCCCAGAGCCTGCCAGTGGAGGCTTATCTGTTG
GGAGGAAGACAGCTCTTCACAGAAGCAAAGAACAAAATGGCATGGAGATCAGCTGCCTGAGCACCTGCGCTGTAGCTTATCTGACAACGC
TGAGGCCACGAGCTCCTGGGTAGCTGTGATCAGGGACATGATAATCTGAGCTATGCAGAGGAGCACATCTGTTGTCAACTGCTGTACCCA
GAAATCTAGAACTCTGCCGACAGCCTCTCCTGGTGAGTCGGGACTCAGCTGAGGACACATCCCCACCCTGCCTCCCATCTGGCCCTTTGG
ACAACTGGCCCTTTGTGACAGGGCTGACTCAAGTGTTAGGCAGGGTCTCAGGCCTTTGATTGCTCACCCCTGCTCCCCAGGCCCTGCCCT
CACTTTTACCAAAGGTTCTCCCTCGGCGGGAGGGCATCTGTGTTGGAGGTGATTTGTCTGGGTTCTTCCTTTTGGTTCCAGAAGGAACTG
TCAGTCATCAGCATCTGCGTTGTTAGCAGTCAGTACCACCCCCGCCCCACAATGACAGTCAAGGCTGACTTGTTGACTGAAGCCTTTTTC
CCAGACCCCTTATTTCGAATCCCCAAGCTTCAGTCCCTCTTGGGGGTGGAGACAAGAGGACATGTGGGAAGCCACGGAAGCAGGTTCTTT
ATGTCCTCTCCTCTGTGGCTGGCAAGGCTCACCTGGCCTTATCCACCCACTTATGGAACCTCAGGAGAGGAGGGCTCCTCCTAAAGGCAT
GCAGCTTGCAGCCCCTCTTTCTCACACGTGTGATCCTAGCGTGAGAGGTCATCCTGCCCTTGCTGAAGTTAGTAGTACTGTACTAAGAGC
TCTGCCCTCATGTGAATTCCTGCCCTGGCGCCTCTTCCCTGGGGCTGAATCAGGCCCTGCTGCAAAACTCCAGGCTTCCCAGGGTTGGGG
AGGCTGTGGGACCAAGGTCCATGTTGGTCCTTCCACTGGGTGCAGCAGGAGCTGGGTCCCGAGAGCCTGGCAGGTGAAACTCTGCAGGCC
TTCCGCCTGATTATTATTTATTCACTCCTTTCCTCACCCCAAGTGCCCTGCTCTCCAGGTGCCTAGAGTATCCTAACTCTTAGGACCAGG
GATTGTCTTGCACCAAGTATGCCTACCCCTGGCCAGTCTGAGGTCTCCTAGCCATAGAACTGACTCCTGGAAGCCTGGAGAGAAGGTGGT
GACACCCATGGGTTCTCAACTGTAAGGAAAAAAGACACCAGACTTTTGTTCCCTAGTGGGGGAAAGCCCTTAGTCTTGTACAGGAGCAGC
TTGCTCCCAAGTCCTTTTGGAAGCTGGCAGAGCTATATTCCTGACAGCCCTGACTGCCAGGTAGAGCAAAAGACATTGGTGGGGGTATGT
GAAGCAAAAGGGGCAGGTGCACACACCTCCACAGTGACCTCTGTGCACACGGTTACCACCAACTGGCTGGCCCTCCTCCTCTTCCCTGGC
CCATTGATCATCCCTTCTCACAGAGGGTCATCATTATTTCCAAATATTGTTTGTCTGATGACTTCCTCTTCCCAGTGCAATTTTTCCCTT
CCTATTTCAACCTCTGGTTCCTGGGATGAGCCATACCCTGGAACTGGCCCACCCACTGTGTCTTCCACGTAAGGGAGACCTTTGCAAAGG
GCATCCAAATGGGTAGGCAGGTGACAGCCGCCGTATTTATTTTGCATAATATTTTAATTTGTATATTTTTGTGATTTATTTTGGCGTTAT
GAGTTTGACTCTCGGGGAGTTTTGTTGTTATGACTCTTGTGTCTTTTGTCACAAAACAATGATATTTGCTAAACGATATATGGAATTTAT

>6492_6492_1_ARID5A-CNNM4_ARID5A_chr2_97202567_ENST00000357485_CNNM4_chr2_97462748_ENST00000377075_length(amino acids)=309AA_BP=1
MGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIKSEILDESDMYTDNRSRKRVSEKNKRDFSAFKDADNELKVKISPQLLLAAHR
FLATEVSQFSPSLISEKILLRLLKYPDVIQELKFDEHNKYYARHYLYTRNKPADYFILILQGKVEVEAGKENMKFETGAFSYYGTMALTS
VPSDRSPAHPTPLSRSASLSYPDRTDVSTAATLAGSSNQFGSSVLGQYISDFSVRALVDLQYIKITRQQYQNGLLASRMENSPQFPIDGC

--------------------------------------------------------------
>6492_6492_2_ARID5A-CNNM4_ARID5A_chr2_97202567_ENST00000357485_CNNM4_chr2_97462749_ENST00000377075_length(transcript)=3382nt_BP=82nt
AGTATCTCAGAGAGCGCGGGGTCCGGACAGCCGCGCGCTGAGGGTCTCGGGGCGGGCGCCGCGGGACCTCTCCGGGCCATGGGGAAGTCC
CACCTGGCCATCGTGCAGAAGGTAAACAACGAGGGTGAGGGTGACCCCTTCTACGAGGTCCTGGGCCTGGTCACCCTGGAGGACGTGATC
GAGGAGATCATCAAGTCGGAGATCCTGGACGAGTCCGACATGTACACTGACAACCGAAGCCGGAAGCGGGTGTCTGAGAAGAACAAGCGT
GACTTCTCTGCCTTCAAGGATGCGGACAATGAGCTCAAAGTGAAAATCTCCCCGCAGCTCCTCCTGGCCGCTCATCGCTTCCTAGCCACA
GAGGTCTCTCAGTTTAGCCCCTCCCTGATATCAGAGAAGATCCTGCTGCGGCTACTCAAGTACCCAGATGTCATTCAGGAACTCAAGTTT
GACGAGCACAATAAGTACTACGCCCGCCATTACCTGTACACCCGAAATAAGCCGGCCGACTACTTCATCCTCATCCTGCAGGGGAAGGTG
GAGGTGGAGGCAGGGAAGGAGAACATGAAGTTTGAGACGGGCGCCTTCTCCTACTATGGGACTATGGCCCTGACCTCGGTCCCCTCCGAC
CGTTCCCCAGCACACCCCACCCCACTCAGCCGCTCAGCCTCCCTCAGTTACCCAGACCGCACAGACGTCTCAACTGCAGCAACCTTGGCA
GGCAGCAGCAACCAGTTTGGCAGCTCTGTCCTGGGCCAGTACATCTCTGACTTCAGCGTCCGGGCACTCGTGGACTTGCAGTACATCAAG
ATCACTCGGCAGCAGTACCAGAACGGGCTGCTGGCTTCTCGCATGGAGAACAGCCCTCAGTTTCCCATAGACGGGTGCACCACCCACATG
GAGAACTTGGCCGAGAAGTCTGAGCTGCCTGTGGTGGACGAGACCACAACTCTTCTCAACGAGCGTAACTCCTTGCTGCACAAAGCCTCC
CACGAGAATGCCATCTGACAGGAGGGCCCGGGGCCCCCTGCCCACCCTGCGGGGGCCTCCCCAGTGGGCCCACATGAAGAGAGGGAACCT
GTTAGTCCAGAAAGGATACGGATAGATAGCCTGTCTGACTGAACAGCCAGATGGCCCCCAGCCTATGGGGGATCTGGCCTCTGCCAGGGA
CCTCTGAGTAGCTCTGAGGTGGCACTGTCCAGCCCTGGATAGGGGGGGCAGTGGGCCAGCTACCGTAAGCAAAGGCTGTTTTTTACTGAG
AGAATTTCTAAAGTAGGCTCATCACTTTTTTTTAAATATCATTTTGGGAAGGGAAGACAGGGTTAAGGAACTTTATTTAAAAAAAAAATA
TTTTTTTCCTAAAAACTATAAAAGAGGAAGGGTTTCTTGTCCCGGGAAGCAACGGACATAATCTGTTCCCAGCCATGGCCTTCCAGCTTG
TGTCCCTGATTCAGGGAGCTCTCCCTTCCTCCTCCTCCTCCTCCTCCGGAGGTGGGATCCCAGAGCCTGCCAGTGGAGGCTTATCTGTTG
GGAGGAAGACAGCTCTTCACAGAAGCAAAGAACAAAATGGCATGGAGATCAGCTGCCTGAGCACCTGCGCTGTAGCTTATCTGACAACGC
TGAGGCCACGAGCTCCTGGGTAGCTGTGATCAGGGACATGATAATCTGAGCTATGCAGAGGAGCACATCTGTTGTCAACTGCTGTACCCA
GAAATCTAGAACTCTGCCGACAGCCTCTCCTGGTGAGTCGGGACTCAGCTGAGGACACATCCCCACCCTGCCTCCCATCTGGCCCTTTGG
ACAACTGGCCCTTTGTGACAGGGCTGACTCAAGTGTTAGGCAGGGTCTCAGGCCTTTGATTGCTCACCCCTGCTCCCCAGGCCCTGCCCT
CACTTTTACCAAAGGTTCTCCCTCGGCGGGAGGGCATCTGTGTTGGAGGTGATTTGTCTGGGTTCTTCCTTTTGGTTCCAGAAGGAACTG
TCAGTCATCAGCATCTGCGTTGTTAGCAGTCAGTACCACCCCCGCCCCACAATGACAGTCAAGGCTGACTTGTTGACTGAAGCCTTTTTC
CCAGACCCCTTATTTCGAATCCCCAAGCTTCAGTCCCTCTTGGGGGTGGAGACAAGAGGACATGTGGGAAGCCACGGAAGCAGGTTCTTT
ATGTCCTCTCCTCTGTGGCTGGCAAGGCTCACCTGGCCTTATCCACCCACTTATGGAACCTCAGGAGAGGAGGGCTCCTCCTAAAGGCAT
GCAGCTTGCAGCCCCTCTTTCTCACACGTGTGATCCTAGCGTGAGAGGTCATCCTGCCCTTGCTGAAGTTAGTAGTACTGTACTAAGAGC
TCTGCCCTCATGTGAATTCCTGCCCTGGCGCCTCTTCCCTGGGGCTGAATCAGGCCCTGCTGCAAAACTCCAGGCTTCCCAGGGTTGGGG
AGGCTGTGGGACCAAGGTCCATGTTGGTCCTTCCACTGGGTGCAGCAGGAGCTGGGTCCCGAGAGCCTGGCAGGTGAAACTCTGCAGGCC
TTCCGCCTGATTATTATTTATTCACTCCTTTCCTCACCCCAAGTGCCCTGCTCTCCAGGTGCCTAGAGTATCCTAACTCTTAGGACCAGG
GATTGTCTTGCACCAAGTATGCCTACCCCTGGCCAGTCTGAGGTCTCCTAGCCATAGAACTGACTCCTGGAAGCCTGGAGAGAAGGTGGT
GACACCCATGGGTTCTCAACTGTAAGGAAAAAAGACACCAGACTTTTGTTCCCTAGTGGGGGAAAGCCCTTAGTCTTGTACAGGAGCAGC
TTGCTCCCAAGTCCTTTTGGAAGCTGGCAGAGCTATATTCCTGACAGCCCTGACTGCCAGGTAGAGCAAAAGACATTGGTGGGGGTATGT
GAAGCAAAAGGGGCAGGTGCACACACCTCCACAGTGACCTCTGTGCACACGGTTACCACCAACTGGCTGGCCCTCCTCCTCTTCCCTGGC
CCATTGATCATCCCTTCTCACAGAGGGTCATCATTATTTCCAAATATTGTTTGTCTGATGACTTCCTCTTCCCAGTGCAATTTTTCCCTT
CCTATTTCAACCTCTGGTTCCTGGGATGAGCCATACCCTGGAACTGGCCCACCCACTGTGTCTTCCACGTAAGGGAGACCTTTGCAAAGG
GCATCCAAATGGGTAGGCAGGTGACAGCCGCCGTATTTATTTTGCATAATATTTTAATTTGTATATTTTTGTGATTTATTTTGGCGTTAT
GAGTTTGACTCTCGGGGAGTTTTGTTGTTATGACTCTTGTGTCTTTTGTCACAAAACAATGATATTTGCTAAACGATATATGGAATTTAT

>6492_6492_2_ARID5A-CNNM4_ARID5A_chr2_97202567_ENST00000357485_CNNM4_chr2_97462749_ENST00000377075_length(amino acids)=309AA_BP=1
MGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIKSEILDESDMYTDNRSRKRVSEKNKRDFSAFKDADNELKVKISPQLLLAAHR
FLATEVSQFSPSLISEKILLRLLKYPDVIQELKFDEHNKYYARHYLYTRNKPADYFILILQGKVEVEAGKENMKFETGAFSYYGTMALTS
VPSDRSPAHPTPLSRSASLSYPDRTDVSTAATLAGSSNQFGSSVLGQYISDFSVRALVDLQYIKITRQQYQNGLLASRMENSPQFPIDGC

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ARID5A-CNNM4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneARID5Achr2:97202567chr2:97462748ENST00000357485+171_3001.3333333333333333595.0SOX9
HgeneARID5Achr2:97202567chr2:97462749ENST00000357485+171_3001.3333333333333333595.0SOX9


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ARID5A-CNNM4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ARID5A-CNNM4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC3495589Jalili syndrome4GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC2931074Cone rod dystrophy amelogenesis imperfecta2ORPHANET
TgeneC0015397Disorder of eye1GENOMICS_ENGLAND