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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:HCP5-HLA-G (FusionGDB2 ID:HG10866TG3135)

Fusion Gene Summary for HCP5-HLA-G

check button Fusion gene summary
Fusion gene informationFusion gene name: HCP5-HLA-G
Fusion gene ID: hg10866tg3135
HgeneTgene
Gene symbol

HCP5

HLA-G

Gene ID

10866

3135

Gene nameHLA complex P5major histocompatibility complex, class I, G
Synonyms6S2650E|D6S2650E|P5-1MHC-G
Cytomap('HCP5')('HLA-G')

6p21.33

6p22.1

Type of genencRNAprotein-coding
DescriptionHLA class I histocompatibility antigen protein P5HLA complex P5 (non-protein coding)HLA complex protein P5MHC class I region ORFHLA class I histocompatibility antigen, alpha chain GHLA G antigenHLA-G histocompatibility antigen, class I, GMHC class I antigen GMHC class Ib antigenb2 microglobulinmutant MHC class I antigenmutant MHC class Ib antigen
Modification date2020031320200320
UniProtAcc

Q6MZN7

.
Ensembl transtripts involved in fusion geneENST00000414046, ENST00000419355, 
ENST00000423496, ENST00000457127, 
Fusion gene scores* DoF score8 X 5 X 6=2402 X 2 X 2=8
# samples 92
** MAII scorelog2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: HCP5 [Title/Abstract] AND HLA-G [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHCP5(31431056)-HLA-G(29795823), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHLA-G

GO:0001915

negative regulation of T cell mediated cytotoxicity

11290782

TgeneHLA-G

GO:0002451

peripheral B cell tolerance induction

24453251

TgeneHLA-G

GO:0002476

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

7584149|8805247

TgeneHLA-G

GO:0002729

positive regulation of natural killer cell cytokine production

16366734|19304799|23184984

TgeneHLA-G

GO:0002767

immune response-inhibiting cell surface receptor signaling pathway

20702625

TgeneHLA-G

GO:0016525

negative regulation of angiogenesis

16809620

TgeneHLA-G

GO:0032735

positive regulation of interleukin-12 production

20702625

TgeneHLA-G

GO:0042130

negative regulation of T cell proliferation

20702625

TgeneHLA-G

GO:0042270

protection from natural killer cell mediated cytotoxicity

11290782

TgeneHLA-G

GO:0045953

negative regulation of natural killer cell mediated cytotoxicity

10190900

TgeneHLA-G

GO:0051898

negative regulation of protein kinase B signaling

24453251

TgeneHLA-G

GO:0060907

positive regulation of macrophage cytokine production

19304799

TgeneHLA-G

GO:0070207

protein homotrimerization

12874224

TgeneHLA-G

GO:0070317

negative regulation of G0 to G1 transition

24453251

TgeneHLA-G

GO:2000353

positive regulation of endothelial cell apoptotic process

16809620

TgeneHLA-G

GO:2000774

positive regulation of cellular senescence

23184984

TgeneHLA-G

GO:2001199

negative regulation of dendritic cell differentiation

20702625



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-51-4080-11AHCP5chr6

31431056

+HLA-Gchr6

29795823

+


Top

Fusion Gene ORF analysis for HCP5-HLA-G

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000414046ENST00000360323HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-3CDSENST00000414046ENST00000376815HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-3CDSENST00000414046ENST00000376818HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-3CDSENST00000414046ENST00000376828HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-3CDSENST00000414046ENST00000428701HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000383621HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000383622HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000383623HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000400665HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000400682HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000412263HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000415687HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000420559HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000422371HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000423011HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000423373HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000426863HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000428952HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000429890HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000430253HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000434881HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000434907HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000444098HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000445373HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000448306HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000449127HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000450984HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000452577HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000452715HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000457132HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000546545HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000546634HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000547241HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000547931HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000550897HCP5chr6

31431056

+HLA-Gchr6

29795823

+
3UTR-intronENST00000414046ENST00000553052HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-3CDSENST00000419355ENST00000360323HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-3CDSENST00000419355ENST00000376815HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-3CDSENST00000419355ENST00000376818HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-3CDSENST00000419355ENST00000376828HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-3CDSENST00000419355ENST00000428701HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-3CDSENST00000423496ENST00000360323HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-3CDSENST00000423496ENST00000376815HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-3CDSENST00000423496ENST00000376818HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-3CDSENST00000423496ENST00000376828HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-3CDSENST00000423496ENST00000428701HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-3CDSENST00000457127ENST00000360323HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-3CDSENST00000457127ENST00000376815HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-3CDSENST00000457127ENST00000376818HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-3CDSENST00000457127ENST00000376828HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-3CDSENST00000457127ENST00000428701HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000383621HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000383622HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000383623HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000400665HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000400682HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000412263HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000415687HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000420559HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000422371HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000423011HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000423373HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000426863HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000428952HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000429890HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000430253HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000434881HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000434907HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000444098HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000445373HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000448306HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000449127HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000450984HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000452577HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000452715HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000457132HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000546545HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000546634HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000547241HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000547931HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000550897HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000419355ENST00000553052HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000383621HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000383622HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000383623HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000400665HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000400682HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000412263HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000415687HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000420559HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000422371HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000423011HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000423373HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000426863HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000428952HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000429890HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000430253HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000434881HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000434907HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000444098HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000445373HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000448306HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000449127HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000450984HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000452577HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000452715HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000457132HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000546545HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000546634HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000547241HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000547931HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000550897HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000423496ENST00000553052HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000383621HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000383622HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000383623HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000400665HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000400682HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000412263HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000415687HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000420559HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000422371HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000423011HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000423373HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000426863HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000428952HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000429890HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000430253HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000434881HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000434907HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000444098HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000445373HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000448306HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000449127HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000450984HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000452577HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000452715HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000457132HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000546545HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000546634HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000547241HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000547931HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000550897HCP5chr6

31431056

+HLA-Gchr6

29795823

+
intron-intronENST00000457127ENST00000553052HCP5chr6

31431056

+HLA-Gchr6

29795823

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for HCP5-HLA-G


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HCP5chr631431056+HLA-Gchr629795823+0.0001312630.99986875
HCP5chr631431056+HLA-Gchr629795823+0.0001312630.99986875


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HCP5-HLA-G


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:31431056/:29795823)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HCP5

Q6MZN7

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for HCP5-HLA-G


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HCP5-HLA-G


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HCP5-HLA-G


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HCP5-HLA-G


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0005586Bipolar Disorder1PSYGENET