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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ADCY2-RPAP2 (FusionGDB2 ID:HG108TG79871) |
Fusion Gene Summary for ADCY2-RPAP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ADCY2-RPAP2 | Fusion gene ID: hg108tg79871 | Hgene | Tgene | Gene symbol | ADCY2 | RPAP2 | Gene ID | 108 | 79871 |
| Gene name | adenylate cyclase 2 | RNA polymerase II associated protein 2 | |
| Synonyms | AC2|HBAC2 | C1orf82|Rtr1 | |
| Cytomap | ('ADCY2')('RPAP2') 5p15.31 | 1p22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | adenylate cyclase type 23',5'-cyclic AMP synthetaseATP pyrophosphate-lyase 2adenylate cyclase 2 (brain)adenylate cyclase IIadenylate cyclase type IIadenylyl cyclase 2type II adenylate cyclase | putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000338316, ENST00000537121, ENST00000513693, | ||
| Fusion gene scores | * DoF score | 11 X 9 X 6=594 | 2 X 2 X 2=8 |
| # samples | 10 | 2 | |
| ** MAII score | log2(10/594*10)=-2.57046293102604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ADCY2 [Title/Abstract] AND RPAP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ADCY2(7698487)-RPAP2(92846281), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ADCY2-RPAP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADCY2-RPAP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across ADCY2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across RPAP2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BLCA | TCGA-FD-A3SR-01A | ADCY2 | chr5 | 7698487 | - | RPAP2 | chr1 | 92846281 | + |
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Fusion Gene ORF analysis for ADCY2-RPAP2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000338316 | ENST00000484158 | ADCY2 | chr5 | 7698487 | - | RPAP2 | chr1 | 92846281 | + |
| 5CDS-intron | ENST00000537121 | ENST00000484158 | ADCY2 | chr5 | 7698487 | - | RPAP2 | chr1 | 92846281 | + |
| In-frame | ENST00000338316 | ENST00000610020 | ADCY2 | chr5 | 7698487 | - | RPAP2 | chr1 | 92846281 | + |
| In-frame | ENST00000537121 | ENST00000610020 | ADCY2 | chr5 | 7698487 | - | RPAP2 | chr1 | 92846281 | + |
| intron-3CDS | ENST00000513693 | ENST00000610020 | ADCY2 | chr5 | 7698487 | - | RPAP2 | chr1 | 92846281 | + |
| intron-intron | ENST00000513693 | ENST00000484158 | ADCY2 | chr5 | 7698487 | - | RPAP2 | chr1 | 92846281 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000338316 | ADCY2 | chr5 | 7698487 | - | ENST00000610020 | RPAP2 | chr1 | 92846281 | + | 16394 | 1198 | 89 | 1348 | 419 |
| ENST00000537121 | ADCY2 | chr5 | 7698487 | - | ENST00000610020 | RPAP2 | chr1 | 92846281 | + | 15831 | 635 | 66 | 785 | 239 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000338316 | ENST00000610020 | ADCY2 | chr5 | 7698487 | - | RPAP2 | chr1 | 92846281 | + | 0.005720754 | 0.99427927 |
| ENST00000537121 | ENST00000610020 | ADCY2 | chr5 | 7698487 | - | RPAP2 | chr1 | 92846281 | + | 0.001049107 | 0.99895084 |
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Fusion Genomic Features for ADCY2-RPAP2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for ADCY2-RPAP2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:7698487/chr1:92846281) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | - | 7 | 25 | 295_300 | 369 | 1092.0 | Nucleotide binding | ATP |
| Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | - | 7 | 25 | 337_339 | 369 | 1092.0 | Nucleotide binding | ATP |
| Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | - | 7 | 25 | 1_45 | 369 | 1092.0 | Topological domain | Cytoplasmic |
| Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | - | 7 | 25 | 108_128 | 369 | 1092.0 | Transmembrane | Helical |
| Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | - | 7 | 25 | 133_153 | 369 | 1092.0 | Transmembrane | Helical |
| Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | - | 7 | 25 | 159_179 | 369 | 1092.0 | Transmembrane | Helical |
| Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | - | 7 | 25 | 187_207 | 369 | 1092.0 | Transmembrane | Helical |
| Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | - | 7 | 25 | 46_66 | 369 | 1092.0 | Transmembrane | Helical |
| Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | - | 7 | 25 | 76_96 | 369 | 1092.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | - | 7 | 25 | 1019_1021 | 369 | 1092.0 | Nucleotide binding | ATP |
| Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | - | 7 | 25 | 1026_1030 | 369 | 1092.0 | Nucleotide binding | ATP |
| Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | - | 7 | 25 | 208_601 | 369 | 1092.0 | Topological domain | Cytoplasmic |
| Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | - | 7 | 25 | 822_1091 | 369 | 1092.0 | Topological domain | Cytoplasmic |
| Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | - | 7 | 25 | 602_622 | 369 | 1092.0 | Transmembrane | Helical |
| Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | - | 7 | 25 | 628_652 | 369 | 1092.0 | Transmembrane | Helical |
| Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | - | 7 | 25 | 680_701 | 369 | 1092.0 | Transmembrane | Helical |
| Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | - | 7 | 25 | 734_755 | 369 | 1092.0 | Transmembrane | Helical |
| Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | - | 7 | 25 | 763_780 | 369 | 1092.0 | Transmembrane | Helical |
| Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | - | 7 | 25 | 801_821 | 369 | 1092.0 | Transmembrane | Helical |
| Tgene | RPAP2 | chr5:7698487 | chr1:92846281 | ENST00000610020 | 10 | 13 | 33_68 | 562 | 613.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | RPAP2 | chr5:7698487 | chr1:92846281 | ENST00000610020 | 10 | 13 | 77_160 | 562 | 613.0 | Zinc finger | RTR1-type |
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Fusion Gene Sequence for ADCY2-RPAP2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >2224_2224_1_ADCY2-RPAP2_ADCY2_chr5_7698487_ENST00000338316_RPAP2_chr1_92846281_ENST00000610020_length(transcript)=16394nt_BP=1198nt AGGCGGCGCGGGGGTGGGACGCGGGCGGCCGCGGCGAGCGGCGCTGCCCGGGCCGGGCGCGCACGGCGGGCGCCCTGTGAGCGGCCCCGA TGTGGCAGGAGGCGATGCGGCGCCGCCGCTACCTGCGGGACCGCTCCGAGGAGGCGGCGGGCGGCGGAGACGGGCTGCCGCGGTCCCGGG ACTGGCTCTACGAGTCCTACTACTGCATGAGCCAGCAGCACCCGCTCATCGTCTTCCTGCTGCTCATCGTCATGGGCTCCTGCCTCGCCC TGCTCGCCGTCTTCTTCGCGCTCGGGCTGGAAGTTGAAGACCATGTGGCGTTTCTAATAACAGTTCCAACTGCCCTGGCGATTTTCTTTG CGATATTTATCCTGGTCTGCATCGAGTCTGTGTTTAAGAAGCTGCTGCGCCTCTTCTCGTTGGTGATATGGATATGCCTTGTTGCCATGG GATACCTGTTCATGTGTTTTGGAGGCACCGTCTCTCCCTGGGACCAGGTATCGTTCTTCCTCTTCATCATCTTCGTGGTGTACACCATGC TGCCCTTCAACATGCGAGACGCCATCATTGCCAGCGTCCTCACCTCCTCCTCCCACACCATCGTGCTTAGCGTCTGCCTGTCTGCAACAC CGGGAGGCAAGGAGCACCTGGTCTGGCAGATCCTGGCCAATGTGATCATTTTCATCTGTGGGAACCTGGCGGGAGCCTACCATAAGCACC TCATGGAACTCGCTCTTCAGCAAACATATCAGGACACCTGTAATTGCATCAAGTCGCGGATCAAGTTGGAATTTGAAAAACGTCAACAGG AGCGGCTTCTGCTCTCCCTGCTGCCGGCCCACATCGCCATGGAGATGAAAGCGGAGATCATCCAGAGGCTGCAGGGCCCCAAGGCGGGCC AGATGGAGAACACAAATAACTTCCACAACCTGTATGTGAAGCGGCATACAAACGTGAGCATCTTATACGCTGACATCGTTGGCTTTACCC GGCTGGCAAGTGACTGCTCCCCGGGAGAACTAGTCCACATGCTGAATGAGCTCTTTGGAAAGTTTGATCAAATTGCAAAGGAGAATGAAT GCATGAGAATTAAAATTTTAGGAGACTGCTACTACTGTGTATCTGGACTCCCTATATCTCTCCCTAACCATGCCAAGAACTGTGTGAAAA TGGGGCTGGACATGTGTGAAGCCATAAAACTGACCCCAATTCTTGGCATTCAGAAACATTCTCAGGAAGGTATGGTGTTTACACGGTTTC TAGACACCCTCCTTGAAGAATTACATCTAAAAAATGAAGACCTTGAAAGTCTAACCATCATATTTAGAACCAGCTGTTTACCAGAGTGAT ATATTCCATGAAGACAAAATAGAAGATGAACTTCTATTCACCGTTTCTGGAATTCTAGCCGCCATGATGGTCTGGTGGTGACTGATAACT AGTTTTATTCCAAGACATACCTTTACCTCTTTAAGTTTCAATCTCCCATCTCCCAGTCCTTCAGTCCCCAACTGCAGAGGATGACCTCCC CAGATAGAGGAGAATCATTACTCCAACAAGAATAACCAAGTCTTTGTATCCCTAGTACAAGACATAGTATTTTTATTCGAAAATGAATGT TTAAGTATTAAATTGAAACTTGAATGAATATTCAAGAAAATATAATGATCTCTACTTTTTCTGGATGATTTCCAGCCATCATATCAGTTT GCCAAAAAAATTGAGAAAGTTATGATTTTGACCTCCCAACCTAAACTCTAAATTCTAAAGATCAGTAAACAATTAGGTCAATAAATACAT ACAATTTAAGATGAAGCCCTTTGGAAGTCTAGTCCAAAACAGGAAAATCTCAGAACTTTCTGGACTCAAGGAAATGCTTTAAATGGAATC TGTAGTTTGTTTGCAGGAGAGACAATTTCTAGAATTTAGATTGCTTTTCAAAATGTTTATCAGGTAGGCAAGTTAGCAGTTGAGGCGGAA CACAGACAACTTGGGGAGCTTTACTGGAAGGCCAAGAAAATACTCTTGGACACTGGAGGAAATGACAGCTACTAAAGCCCAATCATGGAA AAGGACCAGAAAGCAGCCCACTGGAATGGGGAGCTTAGTGGGCAAGGAGGTAGGGATATAATTTCTCTTCTTGGCTCCACCAGTAATTAG CTCTGTGGCCCAGTCACCTAAACTTTCTGGACTTCAGTTCAGGTTGTATGGCAGTAGGCCATAGAATTGGCTACTGCCATACAATCTCTA TGGGAAAGGACTGCAAAAACTAAATTTTATCTCTGTATGGGCAAAGGCTACTGTCATCCTGTTGTTGGTCTGGGGCCACTCTGACAATTT TTTTTAACCTCATTTGATTGTGTAAGGGTCTAACCACAACAAAAAATCATAGTGTAATAGAATTAATCAAGTTCAGCAAGGTCACAGGCT AGATCAATATACAGAAAATCAATTGTATTTTTCTGTTCAGAAAACTCCAAAAATGAAATAAAGAAAATTGTGTTCACAATATCACCAAAG AGAATTAAATACTTAGGAATAAATTTAACAAAATAAGTATAAGACTTGTATAACGAAAACTATAAAACATTCAAGAGGGCTGGGCATGGT GGCTCATGCCTTTAGTTCTAGCACTTTGGAGGCAGAGGCAGGAGGACTGCTTGAGCCCAGGAGTTCAAGACCAGCCTGGGCAACAAAGTG AGACCCTGTCTCCACAAAAAATAAAAATAAAAATAAATTGAAGATGGCCGAATAGGAACAGCTCCAGTCTACAGCTCCCAGCAGGATGGA CACAGAAGATGGGTGATTTCTGCATTTTCAACTAAAGTACCTGGTTCGTCTCACTGGGACTGGCTGGACAGTGGGTGTAGCCCACAGAGG GTTAGCCGAAGCAAGGTGGGGCATCGCCTCACCTGGGAAGCGCCAAGGGGTCGGGGGATTTCCCTTTCCTAGCCAAGGGAAGCCGTGAGT GACTATACCTGGAGGAGGGGTACACTCCTGCCCAAATACTGCTCTTTTCCCACAGTCTTCGCAACTGGCAGACCACGAAATCCCCTCCCA TGCCTGGTTCAGTGGGTCCCACGCCCACAGAGCCTTGCTCACTGCTAGCGCCAGCAGTCTGAAATCGACCTGGGACGTGGGAGCTTGGCG GGGTAGAGGTGTCCGCCATTGCTGAGGCTTGAGTAGGCGGTTCTATGCTCACAGTGTAAACAAAGCAGCAGGGAAGCTCAAACTGGGCAG AGCCCACCACAGCTCAGCAAGGCCTACTGTCTCTGTAGATTCCACCTCCAGGGGCAGGGCATATCTGAACAAAAGGCAGCAGACAGCTTC TCCAGACTTAAACGTCCCTGCCTGACAGCTCTGAAGAGAGCAGTGGTTCTCCCAGCACCGCGTTCAAGCTCCGATAATAGACAGACTGCC TCCTCAAGTGGGTCCCTGACCCCCGTGTAGCCTGACTGGGAGACATCTCCCAGTAGGCGCCGAAAGACACCTCAGAGAGGTAGATGCCCC ACTGGAACGAAGCTTCCACAGTAAGGATCAGGCAGCAATATTTGCTGTTCTGCAGCCTCCACTGGTGACACCCAGGCAAACAGGGTCTGG AGTGGACCTCCAGCAAACTCCAACAGACCTGCAGCTAAGGGGCCTGTCTATTAGAAGGAAAACTAACAGAAAGGAATAGCATCAACATCA AAAAAAGGACATCTACACCAAAACCCCATCCATAGGACACCAACATCAGAGACCAAAGGTAGGTAAAACCACAAAGATGGGGAGAAACCA GACCAGAAAGGCTGAAAATTCCAAAAACCAGAATGCCTCTTCTCCTCCAAAGGAACACAACTCCTTGCCAGCAAGGGAACAAAACTGGAC AGAGAATGAGTTTGACAAGTTGACAGAAGTAGGCTTCAGAAGGTCGGTAATAACAAACTTCTCCAAGCTAAAGGAGCATGTTCTAATGCG TCGCAAGGAAGCTAAAAATCTTGAAAAAAGGTTAGACAAATGGCTAACTAGAATAACCAGTGTAGAGAAGAGCTTAAATGACCTGATGGA GCTGAAAACCACAGTACGGGAACTTCGTGAAGCATACACAAGCTTCAATAGCCAATTCGATCAAGTGGAAGAAAGGATATCAGTAACTGA AGATCAAATTAATGAAATAAAGCGAGAGGACAAGATTAGAGAAAAAAGAGTGAAAAGAAATGAACAAAGCCTCCAAGAAATATGAGACTA TGTGAAAAGACCAAATCTATGTTTGATTGGTGTACCTGAAAGTGATGGGGAGAACAGAACCAAGTTTGAAAACACTCTTCAGGATATTAT CCAGGAGAGCTTCCCCAACCTAGCAAGGAAGGCCAACATTCAAATTCAGGAAATACAGAGAACACCACAAAGATACTCCTCAAGAAGAGC AACCCCAAGACACATAATTGTCAGATTCACCAAGGTTGAAATGAAGGAAAAACTGTTAAGGGCAGCCAGAGAGAAAGGTCAGGTTACCCA CAAAGGGAAGCCCATCAGATTAACAGCGGACCTCTGGGCAGAAACCCTACAAGCCAGAAGAGAATGGGGGCCAATATTCAACATTCTTAA AGAAAAGAATTTTCAACCCAGAATCTCATATCCAGCCAAACTAAGCTTCTTAAGTGAAGGAGAAATAAAATCCTTTACAGACAAGCAAAT GCTGAGAGATTTTGTCACCACCAGGCCTGCCTTACAAGAGCTCCTGAAGTAAGCACTAAAATGGACAGGAACAACCAGTACCAGCCACTG CAAAAACATGCCAAATGGTAAAGACCATCAACACTATGAAGAAACTGCATCAATTAATGGATGAAATAACCAGCTAGCATCATAATGACA GGATCAAATTCCCACATAACAATATTAACCTTAAATGTAAATGGGATAAATGCCCCAATTAAAAGACACAGACTGGCAAATTGAATAAAC AGTCAAGACCCATCAGTGAGCTATATTCAGGAGACCCATCTCATGTGCAAAGACACACATAGGCTCAGAATAAAAGGATGTAGGAAGATT TACCAAGCAAATGGAAAGCAGAAAAAAGCAGGGGTTGCAATCCTAGTCTCTGATAAAACAGACTTTAAACCAACAAAGATCAAAAGAGAC AAAGAAGGTCATTACATAATGGTAAAGGGATCAATTCAACAAGAACAGCTAACTATCCTAAATATATATGCACCCAATACAGGAGCACCC AGATTCATAAAGCAAGTTCTACAAAGAGATTTAGACTCCCACACAATATTAATGGGTGACTTTAACACCCCACTGTCAATATTAGACAGA TCAACAAGACAGAAAATTAACAAAGATATCCAGGACTTGAACTCAGCTCTGGACCAAGCAGACCTAATAGACATCGACAGAACTCTCCAC CCCAAATCAACAGAATATACATTCTTGTCAGCACCACATCACACTTATTCCAAAATTGACCACATAATTGGAAGTAAAGCACTCTTCAGC AAATGCAAAAGAACAGAAATCACAACAAACCGTCTCAGACCACAATGCAATCAAATTAGAACTCAGGATCAAGAATCTCACTCAACTGCA CAACTGCATGGAAACTGAACAACCTGTTCCTGAATGACTACTGGGTAAATAACGAAATGAAGGCAGAAATAAAGATGTTCTTTGGAACCA ACGAGAACAAAGACACAATGTACCAGAATCTCTAGGACATGTTTAAAGCAGTATGTAGAGGGAAATTTATAGCACTAAATGCCCACAAGT GAAAGCAGGAGTGATCTAAAATCAACACCCTAACATCACAATTAAAAGAACTAGAGAAGCAAGACCAAACAAATTCAAAAGCTAGCAGAA GGCAAGAAATAACTAAGATCAGAGCAGAACTGAAGGAGATAGAGACTCAACAAACCCTTCAAAAAATCAGTGAATCCAGGAGCTAGTTTT TTGAAAAGATCAACAAAATTGATAGACCGTTAGCAAGGCTAAAAAAGAAGAAAAGAGAGAAGAGTCAAATAGATGCAATAAAAAATGATA AAGGGGATATCACCACTGATCCCACAGAAATACAAACTACCATCAGCGAATACTATAAACACCTCTACACAAATAAACTAGAAAATCTAG AAGAAATGGATAAATTCCTCGACACATACACCCTCCCAAGACTAAACCAGGAAGAAGTTGAATCTCTGAATAAACCAGTAACAGGTTCTG AAATTGAGGCAATAATTAATAGCCTACCAACCAAAAAAAGTCCAGGACCAGACGGATTCACAGCCAAATTCTACGAAAGGTACAAAGAGG TGCTGGTACCATTCCTTCTGAAACTATTCCAATCAATAGAAGAAAAGGGAATCCTCCCTAACTCATTTTATGAGGCTAACATCATCCTGA TACCAAAGCCTGGCAGAGACACAACAAAAAAAGAGAATTTTAGGCCAATATCCCTGATGAACATCGATGCGAAAATCCTCAATAAAATAC TGGCAAACCGAATCCAGCAGCATATCAAAAAGCTTATCCACCACGATCAAGTCAGCTTCTTCCCTGGGATGCAAGGCTGGTTCAACATAT GCAAATCAATAAACATAATCCATCACATAAACAGAACCAACGGCAAAAACCACATGATTATCTCAATAGATACAAAAAAGGCCTTCAACA AAATTCAACAGCCTTTCATGCTAAAAACCCTCAATAAACTAGGTATTGATGGAATGTATCTCAATATAATAAGAGGTTATTTATGACAAA CCCACAGCCAATAGCATACTGAATGGGCAAAAGCTGGAAGCATTTCCTTTGAAGACCAGCACAAGGCAAGGATGCCCTCTCTCACCACTC CTATTCAACATAGTATTGGAAGTTCTGGCCAGGGCAATCAGGCAAGAGAAAGCAATAAAGCATATTCAAATAGGAAGAGAGGAAGTCAAA TTGTCTCTGTTTGCAGATGACATGATTGTATATTTAGAAAACCCCATCGTCTCATCCCAAAATCTCCTTAAGCTGATAAGCAACTTCAGC AAAGTCTCAGGATACAAAATCGGTGTGCAAAAATCACAAGCATTCCTATATACCAATAATAGACAAAGAGCCAAATCATGAGTGAACTCC CATTCACAATTGCTACTAAGAAAATAAAATACAAAGCACTGCTCAAGGAAATAAGAGAGGACACAAACAAATGGAAAAACATTCCATGCT CATGGATAGGAAGAATCAATATCATGACAATGGCCTTGTTGCCCAAACTGATTTATAGATTCAATGCTATCCCCATCAAGCTACCACTAA CTTTCTTCACAGAATTGGAAAAAACTACTTTAAGATTCATATGGAACCAAAAAAGAGCCCACCTAGCCAAGACAATCCTGGGCAAGAAGA ACAAAGCTGGAGGCATCACACTACCTGACTTCAAACTTTACTACAAGCCTACAGTAACCAAAACAGCATGGCACTGGTACAAAAACAGAT ATGCAGACGAATGGAACAGAATGGAGGCCTCAGAAATAACACCACACGTCTACCACCATCTGATCTTTGACAAACCTGACACACACAAGC AATGGGGAAAAGATTCCCTATTTAATAAATGGTGTTGGGAAAACGGGCTAGCCATATGCAGAAAACTGTAACTGGACCCTTTCCTTACAC CTTATACAAAAATCAACTCAAGATGGAACAAAGACTTAAACGTAAGACCTAGGACCATAAAAATCCTAGAAGAAAACCTGGGCAATACCA TTCAGGACATAGGCATGGGCAAAGACTTCATGTCTAAAACACCAAAAGCAATGGCAACAAAAGCCAAAATTGACAAATGGGTTCTAATTA AAGAGCTTCTGCACAGCAAAATAAACTATCATCAGAGTGAACAGGCAACCTACAGAATGGGAGAACATTTTTGCAATATATCCATCTGAC AAAGGGCTAATATCCAGAATCTACAAAGAACTTAAACAAATTTACAAGAAAAAAGCAAACAACCCCATCAAAAAATGGGCAAAGGATATG AACAGATACTTCTCAAAAGAAGACATTTATGCAGCCAACAGACATATGAAAAAATGCTCATCATCACTAGTCATTAGAGAAATGAAAATC AAAACCACAGTGAGATACCATCTCATGCCAGTTAGAATGGCGATCATTAAAAATCAGGAAACAATAGATGCTGGAGAGGTTGTGGAAAAA TTGGAACGCTTTTACACTGTTGGTGGGAGTGCAAATTAGTCCGACCATTGTGGAAGTCAGTGTGACGACTCCTCAAGGATCTAGAACTGG AAATACCATTTGACCCAGCAATCCCACTATTGGGCATATACCCAAAAGATTATAAATCATTCTACAATAAAGACACATGCACACGTATGT TTATTGCTGCACTATTCACAATAGCAAAGATTTGAAACCAACCCAAATGCCCGTCAATGATAGACTGGATTAAGAAAATGTGGCACATGT ATACCATGGAATACTATGCAGCCATAAAAAAGGATGAGTTCATGTCCTTTGCAGGGACATGGATAAAGCCGGAAACCATCATTCTCAGCA AACTATCACAAGATCAGAAAACCAAACAACGCATGTTCTCACTCATAAGTGGGAGTTAAACAATGAGAACACATGGACACAGGGAGGGTA ACATCACACACCAGGGCCTGTGGGGGGTGGGGGGCTAAGGGAGGGATAACATTAGGAGAAATACCTAATGTAGGTGACAGGTTGGTGGGT GCAGCAAACCACCATGGCATGTGTATACCTATGTAACAAAACTACATGTTCTGCACATGTAACCCAGAACTTAAAGTATAATAAAAAAAA TAATTATTAAATTTTAAAAAACTAGCCAGGCATGGTGCTGCACACCTGTAGTCCCAGCTACTTGAGAGGCTACATTGGGAGGATTGCCTG AGCTTGGGAGGTTGAGGCTGCAGTTAGCTGTGACTGTGCCAGTGCACTCCAGCCTGGGCAACAGAGCAAGACCCTGTCTCAAAAAAAGAA AAAGAAAAATTCAGAGAGATTAAAGAAGGTATCAAGAAATGTAGACACAATCCATGTTCATGAATTGGAAGATCAAATGTTGTTAAGATA GCAGTTCTCCCCAAATTAATCTACAATGCAATCCCTATCAAAATCACAGCAGGCTTTTTTGAAAAATTGACAAGCCAATCTTAAAATCTG TATGAAAACATAAAGGATTCAGAATAGCCAAAATAATTCTGAAAATGAAGAAATAATTCTGATCCAGAACTTACTACAAAGCTACATTAA TCAAGACAGTGTGGTACTGATATAAAGATAGGCATACAGATCAGTGGAACAGAGTCCAGGAATAAACCTTCACATTTATGATCAATTAAG TTTTGACAAAAATCCCAATGAAATTATGGAGAAAAGATGGTCTTTTCAACAAATAGTGCTAGGATATTTGGATATCAAATGCAGAAGAAA TTAATTTAGATTCTTACCTCCTACCATATGCAAAAATAAACTCAAAATTGATCACACACCTACATGTAAGAGCTAAAACTATAAAACATG TAGAAGAAAACATGGGAGAAAACCTAGATGACCTTGGTTTAGGAAGAATTCTTAAGACACTAATAGCACAATTCATAAAAGAAAATATTA ATAAATTGGACTTCATTAAAATATAAAATTTTGTTTCAAAAAACTATTAAGAAAATTAATTGGCCCGGGGAGGTGGTTCACATCTGAAAT CCCTGCACTTTCGGAAGCCAAGGAGGGTGGACCACTTGAGCTCAGGAATTTGAGACCAGACTGGACAACAGAGCAAAATGCCATCTCCAC AAAAAATACAAAAATTAACCAGGCATGGTGGCGTGCTCCTGTAGTCCTGGCTACTCAGAAGGCTGAGGTGGGAGGATCTCTTGACCCTGG GAGGCAGAGGTTGCAGTGAGCCAAGATCACACCACCGCACTAGAGCCTGGGTGACAGAGTGAGACCCTGTCTCAAAAAAAAAAAAAAAAA AAAAAATTAATTGAAAAATCACAGACTGGGAGAAAATATTTTCAAACCATAATAAGTATCTGATAGAGGACTTGTATCTAGACTATGTAA AGAATTCTTAAAACTCAAAAATAAGGCAGACAACTTAAAAATGGACAAAATGTTTGAATAGATATTTCAGCAAAGATATACAAATTGCTT AGCATATGAAGAGATGTGTACTATCACTAGTCATTAGGAAAATACAAGTTAAAAGCAAAATTAGATACCATTTTGGACCCACTAAAATGA CTATAATAAAAAAGACAGACAAAGATATGTGTTGGTGATGATGTGGAGAAACTGGAGCCCTAATGCATTGCTGGTGGGAATGTAAAATGG TGCAGCCACTTTGGAAAACAGTTTGGCAGTTTCTTAAAAAGATAAACATAAGTTTACCATATGATCCTGCTATTCCATGAGAAGAGAAGT GGAAATGTGTTCACATCAAGACTCGTAGGCAAATGTTCATAGCATTATCATTCATATTAGTCAAAAAGTGGAAACCAAATGACCATCAAC TACTGGATTTTTTTTTTTTTTTTAAGAGATGAGGCCTCACTATGTTGCATACTCTGAAGTCAAACTCCTGGGCTCAAACAATCCTCCTGC CTCAGCCTCCTCAGTAACTGGGACTGCAGGCAGGCACCAACATACCCAGATTATTTCTTTTTCTTTTTTTTTTTAACTGGTGGATTTCTT TAAATGATATATGTATACAATGGAGTAGTGATATAGGCTACAATATGGATGCATCTCAAAACATTATGCTTAGTGAAAGAAGTCTGATGC AATATCCCACATATGGTATGTTTCCATTTACAGTCCAGAAAAGGCATATACTAAATTAGCAGTTGCATGGGTCTGATGTGAAAACATGGA TTGCCTGCAGATGGGCACAAGGGATCTTTTGGGGGTGACAAAAATGTTCCAAAACTAAGTTGTAATTTTTGCACAACTTTTATGTGTGTG TGTGTGTGTGTGTGTGAGATGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGCGATCTCAGCTCACCACAACCTCCGCCTCC TGGGTTGAAGCATTTCTCCTGCCTCAGCTTCCTGAGTAGCTGGGATTACAGGCATGTGCCACCATGCCCGGCTAATTTTGTATTTTTAGT AGAGACAGGTTTTCTCCAGGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCTCCTGCCTCGGCCTCCCAAAGCGCTGGGAT TACAGGCGTGAGCCACCACACCCAGCCATTTTTGCACAACTTTATAAACTTTAAAAATAATTGATTTATGCACTTAAAACAGGTAAAGTT TATGTGTATAAATTATACCTTAATAAAGCTATTAAAAGTCAAAGATTATAACAGGGCCTCTCTCTCTCTGACCTAGTGACCTAGGGTAAA GAGAAAAAGAAGCTAGCCAGGCACAGGGGCTCACACCTGTAATCCCAGCACTTTGGGAAGCCAAGATGGGCTGATTGCTTGAGTCCAGGA GTTTGAGACCAACTTGGGCAACATAGCAAAACCCTGTCTCCACCAAAAATAAAAAAAATTAGCCAGGCATGGCGGTGTATGCCTGGAGTC CCAGCTACTCAGGAGTCAGAGGTGGGAGGATCACTTGAGCCCAGGAGGCAGAGGTTGTAGGGAGCCAAGATTGCACCACTGCACTCCAGC CTGGGTGACAGAGCAAGACACTGTCTCAAAAATTAAAAATTAAAAAATGAGGGAAGCTGCTGTATCTCCACTTCTTCCCTCTCTGTGCCC AGAGATATCTCTTCAGTTATCTCACATGCCCTACAAGTCTAGAGACCTCAGGTGAGGAGCCAGTAGCTCAGTATAGAAACTAAGGATCCA AGTGGACAACTGCCACCAAGTCACCACAGGGCCAGCTGCTTTGGGAGGGTGCTGCATCTGCCTCCCATACACTTCTGCCAAGTTTATGTT AGTTTGGGAGGACTGAAGCAGAATTCAGTTCAAAGTACTGTGCTGGATTTTGGTTTCTAAATATTTTCCAATAGAAAAGAACCCAGGCTT CTTGAGAAAATAGCTAGGTTCTAAGGCTAGAGCCAAAAAAATGCAAGATAAGCCTGGAGCATCTTGTAGTACCAGAAACTAAGCAAGTGC TCAAAAACAAAAGGATAGAAGCATGTCAGACAGACACAGGAGCCAATCTGAAAGAGCTCCCTGGCCGGGCACGGTGGCTCACGCCTGTAA TCCCAGCACTTTGGGAGACTGAGGTGGGAGGATGACTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAACATAGGGAGACCCCATCTCTA CAAAAAAGTAAACAATTAGCCGGGCATGGTGGCACACGCCTATAGTCCCAGCTACTCAGGAGGGTGAAGATCACCTGAGACCAGGCGGTC AAGGCTTCAGTGAGCCATGATTGTGGCACTGCACTCCAGCCTAGGCAATAGAGTGAGACTGTCTCAAAAAATAAAATTTTAAAATAACTG AAGAGTATAACTGGATTGTTTGTAACACAAAGGATAAGTGCTTAAGATGATGGAAACCCTATTTATCCTGATGTGATTATTACACATTGC ATGCCTGTACCAAAATATTTCATGTAACCCATAAATATATACATCTACTATGTACCCACAAAAATTAAAAAATGTTTACAGGAGTGAACC ACCGCACCTGGCCAGTGGAGTCTTTTTAAGGTATTATTTAGCATCTTCTGCTTATAGTCATGTCCAAAAACCAGTTGATCTTCCTACTCA TTAGGGGACAAGATCAATTCTCTAAAAAATTAACCTAGCCCAAGGTAAGTGGTACTATTCTGAAATCTGAAAATCTTTAGTAGCCTCACA TTATAAGCCCTTCGTAGAAAAAGAAAAGTAAGCATTTCTAGAAGCACATTTTTGTTGGACTGAGGGTGGGGCAAGGAGCAGGGGTGACTT TCATCTGAAATGTACCTAGGCAGGCCAGAGTCTGAGTTAGGACTGGCTCCTGGGACTTTGCCATCCAGGCCAAGAAGCATGCTCCAGTGT GCATGCACTCTCATCAAAGCCCTAGTCAGGAATCCCAGCCACTCCTCTCCTGTGCAGCACAAGCTGAAGGATAAGGTGTGGGGCAGTGAC TGCGTGGGGCTGCCTGTGTGATTCCTGATAAAGAAATGCCTTCATGAAATGTATTGTTCCCCAATAAAGCTCATTTTCTGTGAGAATTCA TGTGTCCTTTTCCAAATTAAACTAGCAAAATATGAACTTTTGTAAAAGGTCCACACCCAGCCAGTTTTCTACTCTCTAAATGTTCAGGCC TTTGCCTGTCCTTCCCTCAGCAAAAATACTGTGTTTTGGAAAACATTACCAATAAAGGAGCTGGGAGGTGGAATTGGATCAAAATACCTT TAGATGAAAGCAGCAGCACAAGCCATTCCCTTTAAATGAGCTGGCCTCACCTCTGGGGCCTATGAAGAAAAGCCTGCTTCAAGGTGATAG TTTTCATTTTGCTTCCCAGCACCTCTGCAGTCATAACCAAAGTGAAGGACAATATTGCATGACTTCAGAAGAAAGCCATCCAGCCACCTT GCAACATGTTCAGGAAATTCTGGACTCCCTTGGGGCTTGCAAAACTCCCTATGTCTTGCAGACCAAAAGCAAGTTCTCAGTCACCTAGCT CTAGTTTGCATAATTAAAGAAAGTGGAAGCTGGTTCTTTTCTGGGTGACCCTTCACCCAACCAAGCTCATAAGGACTTGTGACAAAAATA AGAGCAATAAAATGAAGTTTTAACAGTGAAAACTTCTATCACTTAGATAAGCAGGAAAAGCCAGTCCCCTAGATGCCCATCTGACCCTAC CTTACTGGGGTCATACAGCCAAAGCAGTGTCCACTTCAGGTACTGTAATGTTTTGAAGTTGACACATATAATTTAATGTAGTTTCATGTC ATAAGTTATAAGACTTTTCAGAGAAACAATTTAGTAATATCTTCTGTAATACCCATCTTCATTTTTTATATGAAAAAGCATAGCCTATGA TCTGTCACCTTGCTCACTCCCACATCCTTACCTCTTATCCTTCTCACATCGTCCCATTAACACATTATCCATCTTTGGGGGGAAAAAATA CACTAAATTTTAGACAGAGTCACTTTCACTATGGCCACAATGGGAGAAAAGACAGTCCACCTTCAAAGTCAACCAGAATGACTCTTAACC TCTCTTGTCTGGGTTGGGCATCCAGATAAGATTTTCTTCGTACAAAGAGTCTTGCTACTAGGAAAAAGAGTTTGAAAATCACTAGTCTAA CTAAATATCTCACTTTAAAAAAAGCACAAACTAAGACTCAATGAGGTTTATCTTCCACAAGATCAGCCAGTTTTAGCAGAGCAGTTGCTA AAACCCAGGTCTCAAACTCCTTGTCTATGGCTCATCTAACTAAGCAACAAAAAGCCCAATGAGCTCTGGAGAGAGAGAGGGAGCTAAAAC AGGACTCAATCAAAACCCACTTGGGATTAGGGAAGCCACCCTCTGTGAGTGAGTTAAACTGAGATTCCCTCCCCTTCACCCTGGCTTCCT TTGCAGAACAAGGGTCACCGCCAGAGGGAAAGCTGAGTTTACGGAGGGGATCCTGGTTGGAGTCAGAGTATACCTTGGTTTGGTTTTGTG GGGTTTTTTGAGACAGGGTCTCACTGTCACCCAGGCTGGAGCACAGTGACAGTCATAGCTCACTATAGCCTCAGACTCCTGGCCTCAAGC GATCCTCCCACCTCAACCTCCAGAGTATCTGGGACTATAGGCACGTACCACCATACCCAGCTAATATTTTTTTTAATTTTATATTTTTTA GAGACAGGGTGTCACTATGTTACCCAGGTCTCAATCACTATGTTACTCCTTGCCTCAAGCAATCCTCTCACCTTGGCCTCCCAAAGTGCT GAGCTTACAGGTGTCAACCACTGTGGCCAGCCACGCATTGGTTTTAAGGTCCAGAATTTTTCTGTTTGGAGCCTTCACAATTAGTTTTAG GTTGGGAGACCGTGAACCCACCAAGCAGCCCTTTAGAGGCTGGAAAAAGAGTTTGGAAAAAGAACTCTGTGGCTTTAGGAATTTCTCTCG GAAATCCTCTAGGGCAGAGAAGGAAAATTTACCAAATGGGAGAGTGTATTAGTCTATTCTTACATTGCTATAAGGAAATACCCCAGACTG GGTAATTTATAAAGGAAAGAGTTTTAATTGACTCACAGTTCCACATGGCTGGGAAAGCCTCAGGAAACTTACAATCATAGCAGAAGGCAA AGGGGAAGAAAGGCACCTTCTTCACAGGGCGGCAGGAAGGAGAAGTGCAGAGCAAAGTGGGGCAAAGCCTCTATAAAGCCATCAGATCTC ATGAGAACTCACTATCATGAGAACAGCAGGGGAGAACCACCCCCATGATCCAATCACCTTCCACGAGGTCCCTCCCCCAACACGTGGGGA TCACAATTTGGATTACAATTCAAGATGAGATTTGGGTGAGGACACAGAGCCGGACCATATCAGAGAGAAAGCTATTACTGAAGACCTTTC TAACTCACTTCTGTAAAGATCAATTCAATAAAAGCAGCAAACACACATACTTTGCTTTCCTTGTGATTAATGCCTTGACTTTTTTGTGGA AAGTAACACCCCAAGAAAGCCAGCTACTCATGTTGGCAATAAAGGTAAAAGTATCTATGGAATAAGGACCATTTTTAGGACAATACTTTC CCTACTACTTAGTTCTAGTCCCTTTTTTGTAGAATTCTGAGGACTTTCTACATACACAATCATGTCATCAGCAAATAAAGATTATTGTAC TTGTTCTTTGCCAACCCATATGTCTTGCCTTACTGCCCTGGTTAGGACCTTCAGAACAATACTGGATATAAGTGGTGAAAGCACATATCC TCCCCTTGTTCCTAATTTTAGAGGGAAAGTACTCAGTCTTTCGCCATTAAGTACAATGTCAGCTGTAAGTTTTCCTAGAGACCCTTTCTC AGCTTGAAGATGTTCCCTGGTATTCATAGTTTGCTAAAAGGTTTTTGTCATTTTAAATCATAAATGGGTGTTGAATTTTGTCAAAGGCTT TTAATGCATCTATGGAGATGATCCAAGTTTTTTTCCTCCTTATTTCTGCTAAGGTTGTATAATTATGCTCATTGGTATTTTAAATGTTAA ATTAACCTTGCGTTCCTGGGATAAGACCCACTGATCATGATGCATTTTCCTCTTTGTAAATTGCTGTATTCATTTTAGTTTCTTCAGGAT TTTGCCTATGTTTGAAGGATATTGGTTTGTAATTTTTCTTGTAACATCTTTGTCTGGTTTTGAAATCAAAGTAATACTGGCCTAATAAAA >2224_2224_1_ADCY2-RPAP2_ADCY2_chr5_7698487_ENST00000338316_RPAP2_chr1_92846281_ENST00000610020_length(amino acids)=419AA_BP=370 MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFF AIFILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSAT PGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAG QMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK -------------------------------------------------------------- >2224_2224_2_ADCY2-RPAP2_ADCY2_chr5_7698487_ENST00000537121_RPAP2_chr1_92846281_ENST00000610020_length(transcript)=15831nt_BP=635nt GAGGAGTTTGGTAGAAATCCCAGAAGAGCTGTTGAGAAGACCAGTGGAGCCACACGTCTAGAGGTCATGGACCTGCGCTGGGCCAGAGAT CTGCATTTGAGAGAAGCCAGCAGATCAGTAGCATTTACCACCCTGAGGCTGGGCGCAGTCACCACGGGACTCCTGACATTCAGAGAGCCA GGAGATAAAGAGAAGTCAGGAAAGGGCCTTGGGAAGAGATGGCGCATCCAGCGAGAGGAAAGCCAGGAGCGGCTTCTGCTCTCCCTGCTG CCGGCCCACATCGCCATGGAGATGAAAGCGGAGATCATCCAGAGGCTGCAGGGCCCCAAGGCGGGCCAGATGGAGAACACAAATAACTTC CACAACCTGTATGTGAAGCGGCATACAAACGTGAGCATCTTATACGCTGACATCGTTGGCTTTACCCGGCTGGCAAGTGACTGCTCCCCG GGAGAACTAGTCCACATGCTGAATGAGCTCTTTGGAAAGTTTGATCAAATTGCAAAGGAGAATGAATGCATGAGAATTAAAATTTTAGGA GACTGCTACTACTGTGTATCTGGACTCCCTATATCTCTCCCTAACCATGCCAAGAACTGTGTGAAAATGGGGCTGGACATGTGTGAAGCC ATAAAACTGACCCCAATTCTTGGCATTCAGAAACATTCTCAGGAAGGTATGGTGTTTACACGGTTTCTAGACACCCTCCTTGAAGAATTA CATCTAAAAAATGAAGACCTTGAAAGTCTAACCATCATATTTAGAACCAGCTGTTTACCAGAGTGATATATTCCATGAAGACAAAATAGA AGATGAACTTCTATTCACCGTTTCTGGAATTCTAGCCGCCATGATGGTCTGGTGGTGACTGATAACTAGTTTTATTCCAAGACATACCTT TACCTCTTTAAGTTTCAATCTCCCATCTCCCAGTCCTTCAGTCCCCAACTGCAGAGGATGACCTCCCCAGATAGAGGAGAATCATTACTC CAACAAGAATAACCAAGTCTTTGTATCCCTAGTACAAGACATAGTATTTTTATTCGAAAATGAATGTTTAAGTATTAAATTGAAACTTGA ATGAATATTCAAGAAAATATAATGATCTCTACTTTTTCTGGATGATTTCCAGCCATCATATCAGTTTGCCAAAAAAATTGAGAAAGTTAT GATTTTGACCTCCCAACCTAAACTCTAAATTCTAAAGATCAGTAAACAATTAGGTCAATAAATACATACAATTTAAGATGAAGCCCTTTG GAAGTCTAGTCCAAAACAGGAAAATCTCAGAACTTTCTGGACTCAAGGAAATGCTTTAAATGGAATCTGTAGTTTGTTTGCAGGAGAGAC AATTTCTAGAATTTAGATTGCTTTTCAAAATGTTTATCAGGTAGGCAAGTTAGCAGTTGAGGCGGAACACAGACAACTTGGGGAGCTTTA CTGGAAGGCCAAGAAAATACTCTTGGACACTGGAGGAAATGACAGCTACTAAAGCCCAATCATGGAAAAGGACCAGAAAGCAGCCCACTG GAATGGGGAGCTTAGTGGGCAAGGAGGTAGGGATATAATTTCTCTTCTTGGCTCCACCAGTAATTAGCTCTGTGGCCCAGTCACCTAAAC TTTCTGGACTTCAGTTCAGGTTGTATGGCAGTAGGCCATAGAATTGGCTACTGCCATACAATCTCTATGGGAAAGGACTGCAAAAACTAA ATTTTATCTCTGTATGGGCAAAGGCTACTGTCATCCTGTTGTTGGTCTGGGGCCACTCTGACAATTTTTTTTAACCTCATTTGATTGTGT AAGGGTCTAACCACAACAAAAAATCATAGTGTAATAGAATTAATCAAGTTCAGCAAGGTCACAGGCTAGATCAATATACAGAAAATCAAT TGTATTTTTCTGTTCAGAAAACTCCAAAAATGAAATAAAGAAAATTGTGTTCACAATATCACCAAAGAGAATTAAATACTTAGGAATAAA TTTAACAAAATAAGTATAAGACTTGTATAACGAAAACTATAAAACATTCAAGAGGGCTGGGCATGGTGGCTCATGCCTTTAGTTCTAGCA CTTTGGAGGCAGAGGCAGGAGGACTGCTTGAGCCCAGGAGTTCAAGACCAGCCTGGGCAACAAAGTGAGACCCTGTCTCCACAAAAAATA AAAATAAAAATAAATTGAAGATGGCCGAATAGGAACAGCTCCAGTCTACAGCTCCCAGCAGGATGGACACAGAAGATGGGTGATTTCTGC ATTTTCAACTAAAGTACCTGGTTCGTCTCACTGGGACTGGCTGGACAGTGGGTGTAGCCCACAGAGGGTTAGCCGAAGCAAGGTGGGGCA TCGCCTCACCTGGGAAGCGCCAAGGGGTCGGGGGATTTCCCTTTCCTAGCCAAGGGAAGCCGTGAGTGACTATACCTGGAGGAGGGGTAC ACTCCTGCCCAAATACTGCTCTTTTCCCACAGTCTTCGCAACTGGCAGACCACGAAATCCCCTCCCATGCCTGGTTCAGTGGGTCCCACG CCCACAGAGCCTTGCTCACTGCTAGCGCCAGCAGTCTGAAATCGACCTGGGACGTGGGAGCTTGGCGGGGTAGAGGTGTCCGCCATTGCT GAGGCTTGAGTAGGCGGTTCTATGCTCACAGTGTAAACAAAGCAGCAGGGAAGCTCAAACTGGGCAGAGCCCACCACAGCTCAGCAAGGC CTACTGTCTCTGTAGATTCCACCTCCAGGGGCAGGGCATATCTGAACAAAAGGCAGCAGACAGCTTCTCCAGACTTAAACGTCCCTGCCT GACAGCTCTGAAGAGAGCAGTGGTTCTCCCAGCACCGCGTTCAAGCTCCGATAATAGACAGACTGCCTCCTCAAGTGGGTCCCTGACCCC CGTGTAGCCTGACTGGGAGACATCTCCCAGTAGGCGCCGAAAGACACCTCAGAGAGGTAGATGCCCCACTGGAACGAAGCTTCCACAGTA AGGATCAGGCAGCAATATTTGCTGTTCTGCAGCCTCCACTGGTGACACCCAGGCAAACAGGGTCTGGAGTGGACCTCCAGCAAACTCCAA CAGACCTGCAGCTAAGGGGCCTGTCTATTAGAAGGAAAACTAACAGAAAGGAATAGCATCAACATCAAAAAAAGGACATCTACACCAAAA CCCCATCCATAGGACACCAACATCAGAGACCAAAGGTAGGTAAAACCACAAAGATGGGGAGAAACCAGACCAGAAAGGCTGAAAATTCCA AAAACCAGAATGCCTCTTCTCCTCCAAAGGAACACAACTCCTTGCCAGCAAGGGAACAAAACTGGACAGAGAATGAGTTTGACAAGTTGA CAGAAGTAGGCTTCAGAAGGTCGGTAATAACAAACTTCTCCAAGCTAAAGGAGCATGTTCTAATGCGTCGCAAGGAAGCTAAAAATCTTG AAAAAAGGTTAGACAAATGGCTAACTAGAATAACCAGTGTAGAGAAGAGCTTAAATGACCTGATGGAGCTGAAAACCACAGTACGGGAAC TTCGTGAAGCATACACAAGCTTCAATAGCCAATTCGATCAAGTGGAAGAAAGGATATCAGTAACTGAAGATCAAATTAATGAAATAAAGC GAGAGGACAAGATTAGAGAAAAAAGAGTGAAAAGAAATGAACAAAGCCTCCAAGAAATATGAGACTATGTGAAAAGACCAAATCTATGTT TGATTGGTGTACCTGAAAGTGATGGGGAGAACAGAACCAAGTTTGAAAACACTCTTCAGGATATTATCCAGGAGAGCTTCCCCAACCTAG CAAGGAAGGCCAACATTCAAATTCAGGAAATACAGAGAACACCACAAAGATACTCCTCAAGAAGAGCAACCCCAAGACACATAATTGTCA GATTCACCAAGGTTGAAATGAAGGAAAAACTGTTAAGGGCAGCCAGAGAGAAAGGTCAGGTTACCCACAAAGGGAAGCCCATCAGATTAA CAGCGGACCTCTGGGCAGAAACCCTACAAGCCAGAAGAGAATGGGGGCCAATATTCAACATTCTTAAAGAAAAGAATTTTCAACCCAGAA TCTCATATCCAGCCAAACTAAGCTTCTTAAGTGAAGGAGAAATAAAATCCTTTACAGACAAGCAAATGCTGAGAGATTTTGTCACCACCA GGCCTGCCTTACAAGAGCTCCTGAAGTAAGCACTAAAATGGACAGGAACAACCAGTACCAGCCACTGCAAAAACATGCCAAATGGTAAAG ACCATCAACACTATGAAGAAACTGCATCAATTAATGGATGAAATAACCAGCTAGCATCATAATGACAGGATCAAATTCCCACATAACAAT ATTAACCTTAAATGTAAATGGGATAAATGCCCCAATTAAAAGACACAGACTGGCAAATTGAATAAACAGTCAAGACCCATCAGTGAGCTA TATTCAGGAGACCCATCTCATGTGCAAAGACACACATAGGCTCAGAATAAAAGGATGTAGGAAGATTTACCAAGCAAATGGAAAGCAGAA AAAAGCAGGGGTTGCAATCCTAGTCTCTGATAAAACAGACTTTAAACCAACAAAGATCAAAAGAGACAAAGAAGGTCATTACATAATGGT AAAGGGATCAATTCAACAAGAACAGCTAACTATCCTAAATATATATGCACCCAATACAGGAGCACCCAGATTCATAAAGCAAGTTCTACA AAGAGATTTAGACTCCCACACAATATTAATGGGTGACTTTAACACCCCACTGTCAATATTAGACAGATCAACAAGACAGAAAATTAACAA AGATATCCAGGACTTGAACTCAGCTCTGGACCAAGCAGACCTAATAGACATCGACAGAACTCTCCACCCCAAATCAACAGAATATACATT CTTGTCAGCACCACATCACACTTATTCCAAAATTGACCACATAATTGGAAGTAAAGCACTCTTCAGCAAATGCAAAAGAACAGAAATCAC AACAAACCGTCTCAGACCACAATGCAATCAAATTAGAACTCAGGATCAAGAATCTCACTCAACTGCACAACTGCATGGAAACTGAACAAC CTGTTCCTGAATGACTACTGGGTAAATAACGAAATGAAGGCAGAAATAAAGATGTTCTTTGGAACCAACGAGAACAAAGACACAATGTAC CAGAATCTCTAGGACATGTTTAAAGCAGTATGTAGAGGGAAATTTATAGCACTAAATGCCCACAAGTGAAAGCAGGAGTGATCTAAAATC AACACCCTAACATCACAATTAAAAGAACTAGAGAAGCAAGACCAAACAAATTCAAAAGCTAGCAGAAGGCAAGAAATAACTAAGATCAGA GCAGAACTGAAGGAGATAGAGACTCAACAAACCCTTCAAAAAATCAGTGAATCCAGGAGCTAGTTTTTTGAAAAGATCAACAAAATTGAT AGACCGTTAGCAAGGCTAAAAAAGAAGAAAAGAGAGAAGAGTCAAATAGATGCAATAAAAAATGATAAAGGGGATATCACCACTGATCCC ACAGAAATACAAACTACCATCAGCGAATACTATAAACACCTCTACACAAATAAACTAGAAAATCTAGAAGAAATGGATAAATTCCTCGAC ACATACACCCTCCCAAGACTAAACCAGGAAGAAGTTGAATCTCTGAATAAACCAGTAACAGGTTCTGAAATTGAGGCAATAATTAATAGC CTACCAACCAAAAAAAGTCCAGGACCAGACGGATTCACAGCCAAATTCTACGAAAGGTACAAAGAGGTGCTGGTACCATTCCTTCTGAAA CTATTCCAATCAATAGAAGAAAAGGGAATCCTCCCTAACTCATTTTATGAGGCTAACATCATCCTGATACCAAAGCCTGGCAGAGACACA ACAAAAAAAGAGAATTTTAGGCCAATATCCCTGATGAACATCGATGCGAAAATCCTCAATAAAATACTGGCAAACCGAATCCAGCAGCAT ATCAAAAAGCTTATCCACCACGATCAAGTCAGCTTCTTCCCTGGGATGCAAGGCTGGTTCAACATATGCAAATCAATAAACATAATCCAT CACATAAACAGAACCAACGGCAAAAACCACATGATTATCTCAATAGATACAAAAAAGGCCTTCAACAAAATTCAACAGCCTTTCATGCTA AAAACCCTCAATAAACTAGGTATTGATGGAATGTATCTCAATATAATAAGAGGTTATTTATGACAAACCCACAGCCAATAGCATACTGAA TGGGCAAAAGCTGGAAGCATTTCCTTTGAAGACCAGCACAAGGCAAGGATGCCCTCTCTCACCACTCCTATTCAACATAGTATTGGAAGT TCTGGCCAGGGCAATCAGGCAAGAGAAAGCAATAAAGCATATTCAAATAGGAAGAGAGGAAGTCAAATTGTCTCTGTTTGCAGATGACAT GATTGTATATTTAGAAAACCCCATCGTCTCATCCCAAAATCTCCTTAAGCTGATAAGCAACTTCAGCAAAGTCTCAGGATACAAAATCGG TGTGCAAAAATCACAAGCATTCCTATATACCAATAATAGACAAAGAGCCAAATCATGAGTGAACTCCCATTCACAATTGCTACTAAGAAA ATAAAATACAAAGCACTGCTCAAGGAAATAAGAGAGGACACAAACAAATGGAAAAACATTCCATGCTCATGGATAGGAAGAATCAATATC ATGACAATGGCCTTGTTGCCCAAACTGATTTATAGATTCAATGCTATCCCCATCAAGCTACCACTAACTTTCTTCACAGAATTGGAAAAA ACTACTTTAAGATTCATATGGAACCAAAAAAGAGCCCACCTAGCCAAGACAATCCTGGGCAAGAAGAACAAAGCTGGAGGCATCACACTA CCTGACTTCAAACTTTACTACAAGCCTACAGTAACCAAAACAGCATGGCACTGGTACAAAAACAGATATGCAGACGAATGGAACAGAATG GAGGCCTCAGAAATAACACCACACGTCTACCACCATCTGATCTTTGACAAACCTGACACACACAAGCAATGGGGAAAAGATTCCCTATTT AATAAATGGTGTTGGGAAAACGGGCTAGCCATATGCAGAAAACTGTAACTGGACCCTTTCCTTACACCTTATACAAAAATCAACTCAAGA TGGAACAAAGACTTAAACGTAAGACCTAGGACCATAAAAATCCTAGAAGAAAACCTGGGCAATACCATTCAGGACATAGGCATGGGCAAA GACTTCATGTCTAAAACACCAAAAGCAATGGCAACAAAAGCCAAAATTGACAAATGGGTTCTAATTAAAGAGCTTCTGCACAGCAAAATA AACTATCATCAGAGTGAACAGGCAACCTACAGAATGGGAGAACATTTTTGCAATATATCCATCTGACAAAGGGCTAATATCCAGAATCTA CAAAGAACTTAAACAAATTTACAAGAAAAAAGCAAACAACCCCATCAAAAAATGGGCAAAGGATATGAACAGATACTTCTCAAAAGAAGA CATTTATGCAGCCAACAGACATATGAAAAAATGCTCATCATCACTAGTCATTAGAGAAATGAAAATCAAAACCACAGTGAGATACCATCT CATGCCAGTTAGAATGGCGATCATTAAAAATCAGGAAACAATAGATGCTGGAGAGGTTGTGGAAAAATTGGAACGCTTTTACACTGTTGG TGGGAGTGCAAATTAGTCCGACCATTGTGGAAGTCAGTGTGACGACTCCTCAAGGATCTAGAACTGGAAATACCATTTGACCCAGCAATC CCACTATTGGGCATATACCCAAAAGATTATAAATCATTCTACAATAAAGACACATGCACACGTATGTTTATTGCTGCACTATTCACAATA GCAAAGATTTGAAACCAACCCAAATGCCCGTCAATGATAGACTGGATTAAGAAAATGTGGCACATGTATACCATGGAATACTATGCAGCC ATAAAAAAGGATGAGTTCATGTCCTTTGCAGGGACATGGATAAAGCCGGAAACCATCATTCTCAGCAAACTATCACAAGATCAGAAAACC AAACAACGCATGTTCTCACTCATAAGTGGGAGTTAAACAATGAGAACACATGGACACAGGGAGGGTAACATCACACACCAGGGCCTGTGG GGGGTGGGGGGCTAAGGGAGGGATAACATTAGGAGAAATACCTAATGTAGGTGACAGGTTGGTGGGTGCAGCAAACCACCATGGCATGTG TATACCTATGTAACAAAACTACATGTTCTGCACATGTAACCCAGAACTTAAAGTATAATAAAAAAAATAATTATTAAATTTTAAAAAACT AGCCAGGCATGGTGCTGCACACCTGTAGTCCCAGCTACTTGAGAGGCTACATTGGGAGGATTGCCTGAGCTTGGGAGGTTGAGGCTGCAG TTAGCTGTGACTGTGCCAGTGCACTCCAGCCTGGGCAACAGAGCAAGACCCTGTCTCAAAAAAAGAAAAAGAAAAATTCAGAGAGATTAA AGAAGGTATCAAGAAATGTAGACACAATCCATGTTCATGAATTGGAAGATCAAATGTTGTTAAGATAGCAGTTCTCCCCAAATTAATCTA CAATGCAATCCCTATCAAAATCACAGCAGGCTTTTTTGAAAAATTGACAAGCCAATCTTAAAATCTGTATGAAAACATAAAGGATTCAGA ATAGCCAAAATAATTCTGAAAATGAAGAAATAATTCTGATCCAGAACTTACTACAAAGCTACATTAATCAAGACAGTGTGGTACTGATAT AAAGATAGGCATACAGATCAGTGGAACAGAGTCCAGGAATAAACCTTCACATTTATGATCAATTAAGTTTTGACAAAAATCCCAATGAAA TTATGGAGAAAAGATGGTCTTTTCAACAAATAGTGCTAGGATATTTGGATATCAAATGCAGAAGAAATTAATTTAGATTCTTACCTCCTA CCATATGCAAAAATAAACTCAAAATTGATCACACACCTACATGTAAGAGCTAAAACTATAAAACATGTAGAAGAAAACATGGGAGAAAAC CTAGATGACCTTGGTTTAGGAAGAATTCTTAAGACACTAATAGCACAATTCATAAAAGAAAATATTAATAAATTGGACTTCATTAAAATA TAAAATTTTGTTTCAAAAAACTATTAAGAAAATTAATTGGCCCGGGGAGGTGGTTCACATCTGAAATCCCTGCACTTTCGGAAGCCAAGG AGGGTGGACCACTTGAGCTCAGGAATTTGAGACCAGACTGGACAACAGAGCAAAATGCCATCTCCACAAAAAATACAAAAATTAACCAGG CATGGTGGCGTGCTCCTGTAGTCCTGGCTACTCAGAAGGCTGAGGTGGGAGGATCTCTTGACCCTGGGAGGCAGAGGTTGCAGTGAGCCA AGATCACACCACCGCACTAGAGCCTGGGTGACAGAGTGAGACCCTGTCTCAAAAAAAAAAAAAAAAAAAAAAATTAATTGAAAAATCACA GACTGGGAGAAAATATTTTCAAACCATAATAAGTATCTGATAGAGGACTTGTATCTAGACTATGTAAAGAATTCTTAAAACTCAAAAATA AGGCAGACAACTTAAAAATGGACAAAATGTTTGAATAGATATTTCAGCAAAGATATACAAATTGCTTAGCATATGAAGAGATGTGTACTA TCACTAGTCATTAGGAAAATACAAGTTAAAAGCAAAATTAGATACCATTTTGGACCCACTAAAATGACTATAATAAAAAAGACAGACAAA GATATGTGTTGGTGATGATGTGGAGAAACTGGAGCCCTAATGCATTGCTGGTGGGAATGTAAAATGGTGCAGCCACTTTGGAAAACAGTT TGGCAGTTTCTTAAAAAGATAAACATAAGTTTACCATATGATCCTGCTATTCCATGAGAAGAGAAGTGGAAATGTGTTCACATCAAGACT CGTAGGCAAATGTTCATAGCATTATCATTCATATTAGTCAAAAAGTGGAAACCAAATGACCATCAACTACTGGATTTTTTTTTTTTTTTT AAGAGATGAGGCCTCACTATGTTGCATACTCTGAAGTCAAACTCCTGGGCTCAAACAATCCTCCTGCCTCAGCCTCCTCAGTAACTGGGA CTGCAGGCAGGCACCAACATACCCAGATTATTTCTTTTTCTTTTTTTTTTTAACTGGTGGATTTCTTTAAATGATATATGTATACAATGG AGTAGTGATATAGGCTACAATATGGATGCATCTCAAAACATTATGCTTAGTGAAAGAAGTCTGATGCAATATCCCACATATGGTATGTTT CCATTTACAGTCCAGAAAAGGCATATACTAAATTAGCAGTTGCATGGGTCTGATGTGAAAACATGGATTGCCTGCAGATGGGCACAAGGG ATCTTTTGGGGGTGACAAAAATGTTCCAAAACTAAGTTGTAATTTTTGCACAACTTTTATGTGTGTGTGTGTGTGTGTGTGTGAGATGGA GTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGCGATCTCAGCTCACCACAACCTCCGCCTCCTGGGTTGAAGCATTTCTCCTGCC TCAGCTTCCTGAGTAGCTGGGATTACAGGCATGTGCCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACAGGTTTTCTCCAGGTTG GTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCTCCTGCCTCGGCCTCCCAAAGCGCTGGGATTACAGGCGTGAGCCACCACACCC AGCCATTTTTGCACAACTTTATAAACTTTAAAAATAATTGATTTATGCACTTAAAACAGGTAAAGTTTATGTGTATAAATTATACCTTAA TAAAGCTATTAAAAGTCAAAGATTATAACAGGGCCTCTCTCTCTCTGACCTAGTGACCTAGGGTAAAGAGAAAAAGAAGCTAGCCAGGCA CAGGGGCTCACACCTGTAATCCCAGCACTTTGGGAAGCCAAGATGGGCTGATTGCTTGAGTCCAGGAGTTTGAGACCAACTTGGGCAACA TAGCAAAACCCTGTCTCCACCAAAAATAAAAAAAATTAGCCAGGCATGGCGGTGTATGCCTGGAGTCCCAGCTACTCAGGAGTCAGAGGT GGGAGGATCACTTGAGCCCAGGAGGCAGAGGTTGTAGGGAGCCAAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGCAAGACACTG TCTCAAAAATTAAAAATTAAAAAATGAGGGAAGCTGCTGTATCTCCACTTCTTCCCTCTCTGTGCCCAGAGATATCTCTTCAGTTATCTC ACATGCCCTACAAGTCTAGAGACCTCAGGTGAGGAGCCAGTAGCTCAGTATAGAAACTAAGGATCCAAGTGGACAACTGCCACCAAGTCA CCACAGGGCCAGCTGCTTTGGGAGGGTGCTGCATCTGCCTCCCATACACTTCTGCCAAGTTTATGTTAGTTTGGGAGGACTGAAGCAGAA TTCAGTTCAAAGTACTGTGCTGGATTTTGGTTTCTAAATATTTTCCAATAGAAAAGAACCCAGGCTTCTTGAGAAAATAGCTAGGTTCTA AGGCTAGAGCCAAAAAAATGCAAGATAAGCCTGGAGCATCTTGTAGTACCAGAAACTAAGCAAGTGCTCAAAAACAAAAGGATAGAAGCA TGTCAGACAGACACAGGAGCCAATCTGAAAGAGCTCCCTGGCCGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACTGAG GTGGGAGGATGACTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAACATAGGGAGACCCCATCTCTACAAAAAAGTAAACAATTAGCCGG GCATGGTGGCACACGCCTATAGTCCCAGCTACTCAGGAGGGTGAAGATCACCTGAGACCAGGCGGTCAAGGCTTCAGTGAGCCATGATTG TGGCACTGCACTCCAGCCTAGGCAATAGAGTGAGACTGTCTCAAAAAATAAAATTTTAAAATAACTGAAGAGTATAACTGGATTGTTTGT AACACAAAGGATAAGTGCTTAAGATGATGGAAACCCTATTTATCCTGATGTGATTATTACACATTGCATGCCTGTACCAAAATATTTCAT GTAACCCATAAATATATACATCTACTATGTACCCACAAAAATTAAAAAATGTTTACAGGAGTGAACCACCGCACCTGGCCAGTGGAGTCT TTTTAAGGTATTATTTAGCATCTTCTGCTTATAGTCATGTCCAAAAACCAGTTGATCTTCCTACTCATTAGGGGACAAGATCAATTCTCT AAAAAATTAACCTAGCCCAAGGTAAGTGGTACTATTCTGAAATCTGAAAATCTTTAGTAGCCTCACATTATAAGCCCTTCGTAGAAAAAG AAAAGTAAGCATTTCTAGAAGCACATTTTTGTTGGACTGAGGGTGGGGCAAGGAGCAGGGGTGACTTTCATCTGAAATGTACCTAGGCAG GCCAGAGTCTGAGTTAGGACTGGCTCCTGGGACTTTGCCATCCAGGCCAAGAAGCATGCTCCAGTGTGCATGCACTCTCATCAAAGCCCT AGTCAGGAATCCCAGCCACTCCTCTCCTGTGCAGCACAAGCTGAAGGATAAGGTGTGGGGCAGTGACTGCGTGGGGCTGCCTGTGTGATT CCTGATAAAGAAATGCCTTCATGAAATGTATTGTTCCCCAATAAAGCTCATTTTCTGTGAGAATTCATGTGTCCTTTTCCAAATTAAACT AGCAAAATATGAACTTTTGTAAAAGGTCCACACCCAGCCAGTTTTCTACTCTCTAAATGTTCAGGCCTTTGCCTGTCCTTCCCTCAGCAA AAATACTGTGTTTTGGAAAACATTACCAATAAAGGAGCTGGGAGGTGGAATTGGATCAAAATACCTTTAGATGAAAGCAGCAGCACAAGC CATTCCCTTTAAATGAGCTGGCCTCACCTCTGGGGCCTATGAAGAAAAGCCTGCTTCAAGGTGATAGTTTTCATTTTGCTTCCCAGCACC TCTGCAGTCATAACCAAAGTGAAGGACAATATTGCATGACTTCAGAAGAAAGCCATCCAGCCACCTTGCAACATGTTCAGGAAATTCTGG ACTCCCTTGGGGCTTGCAAAACTCCCTATGTCTTGCAGACCAAAAGCAAGTTCTCAGTCACCTAGCTCTAGTTTGCATAATTAAAGAAAG TGGAAGCTGGTTCTTTTCTGGGTGACCCTTCACCCAACCAAGCTCATAAGGACTTGTGACAAAAATAAGAGCAATAAAATGAAGTTTTAA CAGTGAAAACTTCTATCACTTAGATAAGCAGGAAAAGCCAGTCCCCTAGATGCCCATCTGACCCTACCTTACTGGGGTCATACAGCCAAA GCAGTGTCCACTTCAGGTACTGTAATGTTTTGAAGTTGACACATATAATTTAATGTAGTTTCATGTCATAAGTTATAAGACTTTTCAGAG AAACAATTTAGTAATATCTTCTGTAATACCCATCTTCATTTTTTATATGAAAAAGCATAGCCTATGATCTGTCACCTTGCTCACTCCCAC ATCCTTACCTCTTATCCTTCTCACATCGTCCCATTAACACATTATCCATCTTTGGGGGGAAAAAATACACTAAATTTTAGACAGAGTCAC TTTCACTATGGCCACAATGGGAGAAAAGACAGTCCACCTTCAAAGTCAACCAGAATGACTCTTAACCTCTCTTGTCTGGGTTGGGCATCC AGATAAGATTTTCTTCGTACAAAGAGTCTTGCTACTAGGAAAAAGAGTTTGAAAATCACTAGTCTAACTAAATATCTCACTTTAAAAAAA GCACAAACTAAGACTCAATGAGGTTTATCTTCCACAAGATCAGCCAGTTTTAGCAGAGCAGTTGCTAAAACCCAGGTCTCAAACTCCTTG TCTATGGCTCATCTAACTAAGCAACAAAAAGCCCAATGAGCTCTGGAGAGAGAGAGGGAGCTAAAACAGGACTCAATCAAAACCCACTTG GGATTAGGGAAGCCACCCTCTGTGAGTGAGTTAAACTGAGATTCCCTCCCCTTCACCCTGGCTTCCTTTGCAGAACAAGGGTCACCGCCA GAGGGAAAGCTGAGTTTACGGAGGGGATCCTGGTTGGAGTCAGAGTATACCTTGGTTTGGTTTTGTGGGGTTTTTTGAGACAGGGTCTCA CTGTCACCCAGGCTGGAGCACAGTGACAGTCATAGCTCACTATAGCCTCAGACTCCTGGCCTCAAGCGATCCTCCCACCTCAACCTCCAG AGTATCTGGGACTATAGGCACGTACCACCATACCCAGCTAATATTTTTTTTAATTTTATATTTTTTAGAGACAGGGTGTCACTATGTTAC CCAGGTCTCAATCACTATGTTACTCCTTGCCTCAAGCAATCCTCTCACCTTGGCCTCCCAAAGTGCTGAGCTTACAGGTGTCAACCACTG TGGCCAGCCACGCATTGGTTTTAAGGTCCAGAATTTTTCTGTTTGGAGCCTTCACAATTAGTTTTAGGTTGGGAGACCGTGAACCCACCA AGCAGCCCTTTAGAGGCTGGAAAAAGAGTTTGGAAAAAGAACTCTGTGGCTTTAGGAATTTCTCTCGGAAATCCTCTAGGGCAGAGAAGG AAAATTTACCAAATGGGAGAGTGTATTAGTCTATTCTTACATTGCTATAAGGAAATACCCCAGACTGGGTAATTTATAAAGGAAAGAGTT TTAATTGACTCACAGTTCCACATGGCTGGGAAAGCCTCAGGAAACTTACAATCATAGCAGAAGGCAAAGGGGAAGAAAGGCACCTTCTTC ACAGGGCGGCAGGAAGGAGAAGTGCAGAGCAAAGTGGGGCAAAGCCTCTATAAAGCCATCAGATCTCATGAGAACTCACTATCATGAGAA CAGCAGGGGAGAACCACCCCCATGATCCAATCACCTTCCACGAGGTCCCTCCCCCAACACGTGGGGATCACAATTTGGATTACAATTCAA GATGAGATTTGGGTGAGGACACAGAGCCGGACCATATCAGAGAGAAAGCTATTACTGAAGACCTTTCTAACTCACTTCTGTAAAGATCAA TTCAATAAAAGCAGCAAACACACATACTTTGCTTTCCTTGTGATTAATGCCTTGACTTTTTTGTGGAAAGTAACACCCCAAGAAAGCCAG CTACTCATGTTGGCAATAAAGGTAAAAGTATCTATGGAATAAGGACCATTTTTAGGACAATACTTTCCCTACTACTTAGTTCTAGTCCCT TTTTTGTAGAATTCTGAGGACTTTCTACATACACAATCATGTCATCAGCAAATAAAGATTATTGTACTTGTTCTTTGCCAACCCATATGT CTTGCCTTACTGCCCTGGTTAGGACCTTCAGAACAATACTGGATATAAGTGGTGAAAGCACATATCCTCCCCTTGTTCCTAATTTTAGAG GGAAAGTACTCAGTCTTTCGCCATTAAGTACAATGTCAGCTGTAAGTTTTCCTAGAGACCCTTTCTCAGCTTGAAGATGTTCCCTGGTAT TCATAGTTTGCTAAAAGGTTTTTGTCATTTTAAATCATAAATGGGTGTTGAATTTTGTCAAAGGCTTTTAATGCATCTATGGAGATGATC CAAGTTTTTTTCCTCCTTATTTCTGCTAAGGTTGTATAATTATGCTCATTGGTATTTTAAATGTTAAATTAACCTTGCGTTCCTGGGATA AGACCCACTGATCATGATGCATTTTCCTCTTTGTAAATTGCTGTATTCATTTTAGTTTCTTCAGGATTTTGCCTATGTTTGAAGGATATT >2224_2224_2_ADCY2-RPAP2_ADCY2_chr5_7698487_ENST00000537121_RPAP2_chr1_92846281_ENST00000610020_length(amino acids)=239AA_BP=190 MDLRWARDLHLREASRSVAFTTLRLGAVTTGLLTFREPGDKEKSGKGLGKRWRIQREESQERLLLSLLPAHIAMEMKAEIIQRLQGPKAG QMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ADCY2-RPAP2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | - | 7 | 25 | 905_922 | 369.6666666666667 | 1092.0 | GNAS |
| Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | - | 7 | 25 | 990_993 | 369.6666666666667 | 1092.0 | GNAS |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ADCY2-RPAP2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ADCY2-RPAP2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ADCY2 | C0005586 | Bipolar Disorder | 2 | CTD_human;PSYGENET |
| Hgene | ADCY2 | C0004096 | Asthma | 1 | CTD_human |
| Hgene | ADCY2 | C0005587 | Depression, Bipolar | 1 | CTD_human |
| Hgene | ADCY2 | C0024713 | Manic Disorder | 1 | CTD_human |
| Hgene | ADCY2 | C0338831 | Manic | 1 | CTD_human |
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