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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ASCC3-GRIK2 (FusionGDB2 ID:HG10973TG2898)

Fusion Gene Summary for ASCC3-GRIK2

check button Fusion gene summary
Fusion gene informationFusion gene name: ASCC3-GRIK2
Fusion gene ID: hg10973tg2898
HgeneTgene
Gene symbol

ASCC3

GRIK2

Gene ID

10973

2898

Gene nameactivating signal cointegrator 1 complex subunit 3glutamate ionotropic receptor kainate type subunit 2
SynonymsASC1p200|HELIC1|RNAHEAA4|GLR6|GLUK6|GLUR6|GluK2|MRT6
Cytomap('ASCC3')('GRIK2')

6q16.3

6q16.3

Type of geneprotein-codingprotein-coding
Descriptionactivating signal cointegrator 1 complex subunit 3ASC-1 complex subunit P200RNA helicase familyhelicase, ATP binding 1trip4 complex subunit p200glutamate receptor ionotropic, kainate 2bA487F5.1excitatory amino acid receptor 4gluR-6glutamate receptor 6glutamate receptor form Aglutamate receptor form Bglutamate receptor form Cglutamate receptor form Dglutamate receptor form E
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000369162, ENST00000522650, 
ENST00000369143, 
Fusion gene scores* DoF score13 X 16 X 12=249613 X 18 X 5=1170
# samples 1417
** MAII scorelog2(14/2496*10)=-4.15611920191728
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(17/1170*10)=-2.78290187833307
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ASCC3 [Title/Abstract] AND GRIK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointASCC3(101214441)-GRIK2(102247523), # samples:1
ASCC3(101214441)-GRIK2(102192474), # samples:1
ASCC3(101037509)-GRIK2(101864082), # samples:1
ASCC3(101214440)-GRIK2(102247522), # samples:1
ASCC3(100978082)-GRIK2(102250312), # samples:1
ASCC3(101052506)-GRIK2(102250312), # samples:1
Anticipated loss of major functional domain due to fusion event.ASCC3-GRIK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ASCC3-GRIK2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ASCC3-GRIK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneASCC3

GO:0006307

DNA dealkylation involved in DNA repair

22055184

HgeneASCC3

GO:0032508

DNA duplex unwinding

22055184

TgeneGRIK2

GO:0050804

modulation of chemical synaptic transmission

15537878



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0AM-01AASCC3chr6

101214440

-GRIK2chr6

102247522

+
ChimerDB4BRCATCGA-AN-A0AM-01AASCC3chr6

101214441

-GRIK2chr6

102192474

+
ChimerDB4BRCATCGA-AN-A0AM-01AASCC3chr6

101214441

-GRIK2chr6

102247523

+
ChimerDB4BRCATCGA-E9-A248-01AASCC3chr6

100978082

-GRIK2chr6

102250312

-
ChimerDB4BRCATCGA-E9-A248-01AASCC3chr6

101052506

-GRIK2chr6

102250312

-
ChimerDB4UCECTCGA-EY-A3QX-01AASCC3chr6

101037509

-GRIK2chr6

101864082

-


Top

Fusion Gene ORF analysis for ASCC3-GRIK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000369162ENST00000318991ASCC3chr6

101214440

-GRIK2chr6

102247522

+
5CDS-intronENST00000369162ENST00000318991ASCC3chr6

101214441

-GRIK2chr6

102192474

+
5CDS-intronENST00000369162ENST00000318991ASCC3chr6

101214441

-GRIK2chr6

102247523

+
5CDS-intronENST00000369162ENST00000318991ASCC3chr6

101037509

-GRIK2chr6

101864082

-
5CDS-intronENST00000369162ENST00000358361ASCC3chr6

101214440

-GRIK2chr6

102247522

+
5CDS-intronENST00000369162ENST00000358361ASCC3chr6

101214441

-GRIK2chr6

102192474

+
5CDS-intronENST00000369162ENST00000358361ASCC3chr6

101214441

-GRIK2chr6

102247523

+
5CDS-intronENST00000369162ENST00000358361ASCC3chr6

101037509

-GRIK2chr6

101864082

-
5CDS-intronENST00000369162ENST00000369134ASCC3chr6

101214440

-GRIK2chr6

102247522

+
5CDS-intronENST00000369162ENST00000369134ASCC3chr6

101214441

-GRIK2chr6

102192474

+
5CDS-intronENST00000369162ENST00000369134ASCC3chr6

101214441

-GRIK2chr6

102247523

+
5CDS-intronENST00000369162ENST00000369134ASCC3chr6

101037509

-GRIK2chr6

101864082

-
5CDS-intronENST00000369162ENST00000369137ASCC3chr6

101214440

-GRIK2chr6

102247522

+
5CDS-intronENST00000369162ENST00000369137ASCC3chr6

101214441

-GRIK2chr6

102192474

+
5CDS-intronENST00000369162ENST00000369137ASCC3chr6

101214441

-GRIK2chr6

102247523

+
5CDS-intronENST00000369162ENST00000369137ASCC3chr6

101037509

-GRIK2chr6

101864082

-
5CDS-intronENST00000369162ENST00000369138ASCC3chr6

101214441

-GRIK2chr6

102192474

+
5CDS-intronENST00000369162ENST00000369138ASCC3chr6

101037509

-GRIK2chr6

101864082

-
5CDS-intronENST00000369162ENST00000413795ASCC3chr6

101214441

-GRIK2chr6

102192474

+
5CDS-intronENST00000369162ENST00000413795ASCC3chr6

101037509

-GRIK2chr6

101864082

-
5CDS-intronENST00000369162ENST00000421544ASCC3chr6

101214441

-GRIK2chr6

102192474

+
5CDS-intronENST00000369162ENST00000421544ASCC3chr6

101037509

-GRIK2chr6

101864082

-
5CDS-intronENST00000522650ENST00000318991ASCC3chr6

101214440

-GRIK2chr6

102247522

+
5CDS-intronENST00000522650ENST00000318991ASCC3chr6

101214441

-GRIK2chr6

102192474

+
5CDS-intronENST00000522650ENST00000318991ASCC3chr6

101214441

-GRIK2chr6

102247523

+
5CDS-intronENST00000522650ENST00000358361ASCC3chr6

101214440

-GRIK2chr6

102247522

+
5CDS-intronENST00000522650ENST00000358361ASCC3chr6

101214441

-GRIK2chr6

102192474

+
5CDS-intronENST00000522650ENST00000358361ASCC3chr6

101214441

-GRIK2chr6

102247523

+
5CDS-intronENST00000522650ENST00000369134ASCC3chr6

101214440

-GRIK2chr6

102247522

+
5CDS-intronENST00000522650ENST00000369134ASCC3chr6

101214441

-GRIK2chr6

102192474

+
5CDS-intronENST00000522650ENST00000369134ASCC3chr6

101214441

-GRIK2chr6

102247523

+
5CDS-intronENST00000522650ENST00000369137ASCC3chr6

101214440

-GRIK2chr6

102247522

+
5CDS-intronENST00000522650ENST00000369137ASCC3chr6

101214441

-GRIK2chr6

102192474

+
5CDS-intronENST00000522650ENST00000369137ASCC3chr6

101214441

-GRIK2chr6

102247523

+
5CDS-intronENST00000522650ENST00000369138ASCC3chr6

101214441

-GRIK2chr6

102192474

+
5CDS-intronENST00000522650ENST00000413795ASCC3chr6

101214441

-GRIK2chr6

102192474

+
5CDS-intronENST00000522650ENST00000421544ASCC3chr6

101214441

-GRIK2chr6

102192474

+
Frame-shiftENST00000369162ENST00000369138ASCC3chr6

101214440

-GRIK2chr6

102247522

+
Frame-shiftENST00000369162ENST00000369138ASCC3chr6

101214441

-GRIK2chr6

102247523

+
Frame-shiftENST00000369162ENST00000413795ASCC3chr6

101214440

-GRIK2chr6

102247522

+
Frame-shiftENST00000369162ENST00000413795ASCC3chr6

101214441

-GRIK2chr6

102247523

+
Frame-shiftENST00000369162ENST00000421544ASCC3chr6

101214440

-GRIK2chr6

102247522

+
Frame-shiftENST00000369162ENST00000421544ASCC3chr6

101214441

-GRIK2chr6

102247523

+
Frame-shiftENST00000522650ENST00000369138ASCC3chr6

101214440

-GRIK2chr6

102247522

+
Frame-shiftENST00000522650ENST00000369138ASCC3chr6

101214441

-GRIK2chr6

102247523

+
Frame-shiftENST00000522650ENST00000413795ASCC3chr6

101214440

-GRIK2chr6

102247522

+
Frame-shiftENST00000522650ENST00000413795ASCC3chr6

101214441

-GRIK2chr6

102247523

+
Frame-shiftENST00000522650ENST00000421544ASCC3chr6

101214440

-GRIK2chr6

102247522

+
Frame-shiftENST00000522650ENST00000421544ASCC3chr6

101214441

-GRIK2chr6

102247523

+
intron-3CDSENST00000369143ENST00000369138ASCC3chr6

101214440

-GRIK2chr6

102247522

+
intron-3CDSENST00000369143ENST00000369138ASCC3chr6

101214441

-GRIK2chr6

102247523

+
intron-3CDSENST00000369143ENST00000413795ASCC3chr6

101214440

-GRIK2chr6

102247522

+
intron-3CDSENST00000369143ENST00000413795ASCC3chr6

101214441

-GRIK2chr6

102247523

+
intron-3CDSENST00000369143ENST00000421544ASCC3chr6

101214440

-GRIK2chr6

102247522

+
intron-3CDSENST00000369143ENST00000421544ASCC3chr6

101214441

-GRIK2chr6

102247523

+
intron-intronENST00000369143ENST00000318991ASCC3chr6

101214440

-GRIK2chr6

102247522

+
intron-intronENST00000369143ENST00000318991ASCC3chr6

101214441

-GRIK2chr6

102192474

+
intron-intronENST00000369143ENST00000318991ASCC3chr6

101214441

-GRIK2chr6

102247523

+
intron-intronENST00000369143ENST00000318991ASCC3chr6

100978082

-GRIK2chr6

102250312

-
intron-intronENST00000369143ENST00000318991ASCC3chr6

101052506

-GRIK2chr6

102250312

-
intron-intronENST00000369143ENST00000318991ASCC3chr6

101037509

-GRIK2chr6

101864082

-
intron-intronENST00000369143ENST00000358361ASCC3chr6

101214440

-GRIK2chr6

102247522

+
intron-intronENST00000369143ENST00000358361ASCC3chr6

101214441

-GRIK2chr6

102192474

+
intron-intronENST00000369143ENST00000358361ASCC3chr6

101214441

-GRIK2chr6

102247523

+
intron-intronENST00000369143ENST00000358361ASCC3chr6

100978082

-GRIK2chr6

102250312

-
intron-intronENST00000369143ENST00000358361ASCC3chr6

101052506

-GRIK2chr6

102250312

-
intron-intronENST00000369143ENST00000358361ASCC3chr6

101037509

-GRIK2chr6

101864082

-
intron-intronENST00000369143ENST00000369134ASCC3chr6

101214440

-GRIK2chr6

102247522

+
intron-intronENST00000369143ENST00000369134ASCC3chr6

101214441

-GRIK2chr6

102192474

+
intron-intronENST00000369143ENST00000369134ASCC3chr6

101214441

-GRIK2chr6

102247523

+
intron-intronENST00000369143ENST00000369134ASCC3chr6

100978082

-GRIK2chr6

102250312

-
intron-intronENST00000369143ENST00000369134ASCC3chr6

101052506

-GRIK2chr6

102250312

-
intron-intronENST00000369143ENST00000369134ASCC3chr6

101037509

-GRIK2chr6

101864082

-
intron-intronENST00000369143ENST00000369137ASCC3chr6

101214440

-GRIK2chr6

102247522

+
intron-intronENST00000369143ENST00000369137ASCC3chr6

101214441

-GRIK2chr6

102192474

+
intron-intronENST00000369143ENST00000369137ASCC3chr6

101214441

-GRIK2chr6

102247523

+
intron-intronENST00000369143ENST00000369137ASCC3chr6

100978082

-GRIK2chr6

102250312

-
intron-intronENST00000369143ENST00000369137ASCC3chr6

101052506

-GRIK2chr6

102250312

-
intron-intronENST00000369143ENST00000369137ASCC3chr6

101037509

-GRIK2chr6

101864082

-
intron-intronENST00000369143ENST00000369138ASCC3chr6

101214441

-GRIK2chr6

102192474

+
intron-intronENST00000369143ENST00000369138ASCC3chr6

100978082

-GRIK2chr6

102250312

-
intron-intronENST00000369143ENST00000369138ASCC3chr6

101052506

-GRIK2chr6

102250312

-
intron-intronENST00000369143ENST00000369138ASCC3chr6

101037509

-GRIK2chr6

101864082

-
intron-intronENST00000369143ENST00000413795ASCC3chr6

101214441

-GRIK2chr6

102192474

+
intron-intronENST00000369143ENST00000413795ASCC3chr6

100978082

-GRIK2chr6

102250312

-
intron-intronENST00000369143ENST00000413795ASCC3chr6

101052506

-GRIK2chr6

102250312

-
intron-intronENST00000369143ENST00000413795ASCC3chr6

101037509

-GRIK2chr6

101864082

-
intron-intronENST00000369143ENST00000421544ASCC3chr6

101214441

-GRIK2chr6

102192474

+
intron-intronENST00000369143ENST00000421544ASCC3chr6

100978082

-GRIK2chr6

102250312

-
intron-intronENST00000369143ENST00000421544ASCC3chr6

101052506

-GRIK2chr6

102250312

-
intron-intronENST00000369143ENST00000421544ASCC3chr6

101037509

-GRIK2chr6

101864082

-
intron-intronENST00000369162ENST00000318991ASCC3chr6

100978082

-GRIK2chr6

102250312

-
intron-intronENST00000369162ENST00000318991ASCC3chr6

101052506

-GRIK2chr6

102250312

-
intron-intronENST00000369162ENST00000358361ASCC3chr6

100978082

-GRIK2chr6

102250312

-
intron-intronENST00000369162ENST00000358361ASCC3chr6

101052506

-GRIK2chr6

102250312

-
intron-intronENST00000369162ENST00000369134ASCC3chr6

100978082

-GRIK2chr6

102250312

-
intron-intronENST00000369162ENST00000369134ASCC3chr6

101052506

-GRIK2chr6

102250312

-
intron-intronENST00000369162ENST00000369137ASCC3chr6

100978082

-GRIK2chr6

102250312

-
intron-intronENST00000369162ENST00000369137ASCC3chr6

101052506

-GRIK2chr6

102250312

-
intron-intronENST00000369162ENST00000369138ASCC3chr6

100978082

-GRIK2chr6

102250312

-
intron-intronENST00000369162ENST00000369138ASCC3chr6

101052506

-GRIK2chr6

102250312

-
intron-intronENST00000369162ENST00000413795ASCC3chr6

100978082

-GRIK2chr6

102250312

-
intron-intronENST00000369162ENST00000413795ASCC3chr6

101052506

-GRIK2chr6

102250312

-
intron-intronENST00000369162ENST00000421544ASCC3chr6

100978082

-GRIK2chr6

102250312

-
intron-intronENST00000369162ENST00000421544ASCC3chr6

101052506

-GRIK2chr6

102250312

-
intron-intronENST00000522650ENST00000318991ASCC3chr6

100978082

-GRIK2chr6

102250312

-
intron-intronENST00000522650ENST00000318991ASCC3chr6

101052506

-GRIK2chr6

102250312

-
intron-intronENST00000522650ENST00000318991ASCC3chr6

101037509

-GRIK2chr6

101864082

-
intron-intronENST00000522650ENST00000358361ASCC3chr6

100978082

-GRIK2chr6

102250312

-
intron-intronENST00000522650ENST00000358361ASCC3chr6

101052506

-GRIK2chr6

102250312

-
intron-intronENST00000522650ENST00000358361ASCC3chr6

101037509

-GRIK2chr6

101864082

-
intron-intronENST00000522650ENST00000369134ASCC3chr6

100978082

-GRIK2chr6

102250312

-
intron-intronENST00000522650ENST00000369134ASCC3chr6

101052506

-GRIK2chr6

102250312

-
intron-intronENST00000522650ENST00000369134ASCC3chr6

101037509

-GRIK2chr6

101864082

-
intron-intronENST00000522650ENST00000369137ASCC3chr6

100978082

-GRIK2chr6

102250312

-
intron-intronENST00000522650ENST00000369137ASCC3chr6

101052506

-GRIK2chr6

102250312

-
intron-intronENST00000522650ENST00000369137ASCC3chr6

101037509

-GRIK2chr6

101864082

-
intron-intronENST00000522650ENST00000369138ASCC3chr6

100978082

-GRIK2chr6

102250312

-
intron-intronENST00000522650ENST00000369138ASCC3chr6

101052506

-GRIK2chr6

102250312

-
intron-intronENST00000522650ENST00000369138ASCC3chr6

101037509

-GRIK2chr6

101864082

-
intron-intronENST00000522650ENST00000413795ASCC3chr6

100978082

-GRIK2chr6

102250312

-
intron-intronENST00000522650ENST00000413795ASCC3chr6

101052506

-GRIK2chr6

102250312

-
intron-intronENST00000522650ENST00000413795ASCC3chr6

101037509

-GRIK2chr6

101864082

-
intron-intronENST00000522650ENST00000421544ASCC3chr6

100978082

-GRIK2chr6

102250312

-
intron-intronENST00000522650ENST00000421544ASCC3chr6

101052506

-GRIK2chr6

102250312

-
intron-intronENST00000522650ENST00000421544ASCC3chr6

101037509

-GRIK2chr6

101864082

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for ASCC3-GRIK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ASCC3chr6101214440-GRIK2chr6102192473+0.000287280.99971265
ASCC3chr6101214440-GRIK2chr6102247522+7.64E-050.9999236
ASCC3chr6101214440-GRIK2chr6102192473+0.000287280.99971265
ASCC3chr6101214440-GRIK2chr6102247522+7.64E-050.9999236


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ASCC3-GRIK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:101214441/:102247523)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ASCC3-GRIK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ASCC3-GRIK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ASCC3-GRIK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ASCC3-GRIK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneASCC3C0020796Profound Mental Retardation1CTD_human
HgeneASCC3C0025363Mental Retardation, Psychosocial1CTD_human
HgeneASCC3C0917816Mental deficiency1CTD_human
HgeneASCC3C3714756Intellectual Disability1CTD_human
TgeneC0005586Bipolar Disorder3CTD_human;PSYGENET
TgeneC0004352Autistic Disorder2CTD_human
TgeneC0005587Depression, Bipolar1CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human;UNIPROT
TgeneC0007102Malignant tumor of colon1CTD_human
TgeneC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneC0009375Colonic Neoplasms1CTD_human
TgeneC0013146Drug abuse1CTD_human
TgeneC0013170Drug habituation1CTD_human
TgeneC0013222Drug Use Disorders1CTD_human
TgeneC0014859Esophageal Neoplasms1CTD_human
TgeneC0016722Frigidity1CTD_human
TgeneC0017636Glioblastoma1CTD_human
TgeneC0020594Hypoactive Sexual Desire Disorder1CTD_human
TgeneC0023903Liver neoplasms1CTD_human
TgeneC0024232Lymphatic Metastasis1CTD_human
TgeneC0024713Manic Disorder1CTD_human
TgeneC0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgeneC0029261Orgasmic Disorder1CTD_human
TgeneC0033953Psychosexual Disorders1CTD_human
TgeneC0036341Schizophrenia1CTD_human
TgeneC0036902Sexual Arousal Disorder1CTD_human
TgeneC0038580Substance Dependence1CTD_human
TgeneC0038586Substance Use Disorders1CTD_human
TgeneC0236969Substance-Related Disorders1CTD_human
TgeneC0334588Giant Cell Glioblastoma1CTD_human
TgeneC0338831Manic1CTD_human
TgeneC0345904Malignant neoplasm of liver1CTD_human
TgeneC0525045Mood Disorders1PSYGENET
TgeneC0546837Malignant neoplasm of esophagus1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC0740858Substance abuse problem1CTD_human
TgeneC0919267ovarian neoplasm1CTD_human
TgeneC1140680Malignant neoplasm of ovary1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC1510472Drug Dependence1CTD_human
TgeneC1621958Glioblastoma Multiforme1CTD_human
TgeneC1970198MENTAL RETARDATION, AUTOSOMAL RECESSIVE 61CTD_human;GENOMICS_ENGLAND
TgeneC4316881Prescription Drug Abuse1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human