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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DSTN-MYO5C (FusionGDB2 ID:HG11034TG55930)

Fusion Gene Summary for DSTN-MYO5C

check button Fusion gene summary
Fusion gene informationFusion gene name: DSTN-MYO5C
Fusion gene ID: hg11034tg55930
HgeneTgene
Gene symbol

DSTN

MYO5C

Gene ID

11034

55930

Gene namedestrin, actin depolymerizing factormyosin VC
SynonymsACTDP|ADF|HEL32|bA462D18.2-
Cytomap('DSTN')('MYO5C')

20p12.1

15q21.2

Type of geneprotein-codingprotein-coding
Descriptiondestrinactin-depolymerizing factorbA462D18.2 (destrin (actin depolymerizing factor ADF) (ACTDP))epididymis luminal protein 32epididymis secretory sperm binding proteinunconventional myosin-Vcmyosin 5Cmyosin-Vc
Modification date2020032720200313
UniProtAcc.

Q9NQX4

Ensembl transtripts involved in fusion geneENST00000246069, ENST00000474024, 
Fusion gene scores* DoF score18 X 10 X 11=19805 X 5 X 5=125
# samples 247
** MAII scorelog2(24/1980*10)=-3.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/125*10)=-0.836501267717121
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DSTN [Title/Abstract] AND MYO5C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDSTN(17550856)-MYO5C(52553324), # samples:2
Anticipated loss of major functional domain due to fusion event.DSTN-MYO5C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DSTN-MYO5C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DSTN-MYO5C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DSTN-MYO5C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDSTN

GO:0030042

actin filament depolymerization

11812157


check buttonFusion gene breakpoints across DSTN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MYO5C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A8IM-01ADSTNchr20

17550856

+MYO5Cchr15

52553324

-
ChimerDB4PRADTCGA-KK-A8IMDSTNchr20

17550856

+MYO5Cchr15

52548917

-
ChimerDB4PRADTCGA-KK-A8IMDSTNchr20

17550856

+MYO5Cchr15

52553324

-


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Fusion Gene ORF analysis for DSTN-MYO5C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000246069ENST00000541028DSTNchr20

17550856

+MYO5Cchr15

52553324

-
5CDS-intronENST00000246069ENST00000541028DSTNchr20

17550856

+MYO5Cchr15

52548917

-
5UTR-3CDSENST00000474024ENST00000261839DSTNchr20

17550856

+MYO5Cchr15

52553324

-
5UTR-3CDSENST00000474024ENST00000261839DSTNchr20

17550856

+MYO5Cchr15

52548917

-
5UTR-3CDSENST00000474024ENST00000443683DSTNchr20

17550856

+MYO5Cchr15

52553324

-
5UTR-3CDSENST00000474024ENST00000443683DSTNchr20

17550856

+MYO5Cchr15

52548917

-
5UTR-5UTRENST00000474024ENST00000541028DSTNchr20

17550856

+MYO5Cchr15

52553324

-
5UTR-intronENST00000474024ENST00000541028DSTNchr20

17550856

+MYO5Cchr15

52548917

-
Frame-shiftENST00000246069ENST00000261839DSTNchr20

17550856

+MYO5Cchr15

52548917

-
In-frameENST00000246069ENST00000261839DSTNchr20

17550856

+MYO5Cchr15

52553324

-
In-frameENST00000246069ENST00000443683DSTNchr20

17550856

+MYO5Cchr15

52553324

-
In-frameENST00000246069ENST00000443683DSTNchr20

17550856

+MYO5Cchr15

52548917

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000246069DSTNchr2017550856+ENST00000261839MYO5Cchr1552553324-611134929845301410
ENST00000246069DSTNchr2017550856+ENST00000443683MYO5Cchr1552553324-20593496361685349
ENST00000246069DSTNchr2017550856+ENST00000443683MYO5Cchr1552548917-18333492871459390

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000246069ENST00000261839DSTNchr2017550856+MYO5Cchr1552553324-0.001070160.9989298
ENST00000246069ENST00000443683DSTNchr2017550856+MYO5Cchr1552553324-0.0072797670.99272025
ENST00000246069ENST00000443683DSTNchr2017550856+MYO5Cchr1552548917-0.006791720.9932082

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Fusion Genomic Features for DSTN-MYO5C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for DSTN-MYO5C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:17550856/chr15:52553324)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MYO5C

Q9NQX4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMYO5Cchr20:17550856chr15:52548917ENST00000261839941884_13514371743.0Coiled coilOntology_term=ECO:0000255
TgeneMYO5Cchr20:17550856chr15:52553324ENST00000261839841884_13513491743.0Coiled coilOntology_term=ECO:0000255
TgeneMYO5Cchr20:17550856chr15:52548917ENST000002618399411421_16974371743.0DomainDilute
TgeneMYO5Cchr20:17550856chr15:52548917ENST00000261839941756_7794371743.0DomainIQ 1
TgeneMYO5Cchr20:17550856chr15:52548917ENST00000261839941780_8064371743.0DomainIQ 2
TgeneMYO5Cchr20:17550856chr15:52548917ENST00000261839941807_8294371743.0DomainIQ 3
TgeneMYO5Cchr20:17550856chr15:52548917ENST00000261839941830_8544371743.0DomainIQ 4
TgeneMYO5Cchr20:17550856chr15:52548917ENST00000261839941855_8844371743.0DomainIQ 5
TgeneMYO5Cchr20:17550856chr15:52553324ENST000002618398411421_16973491743.0DomainDilute
TgeneMYO5Cchr20:17550856chr15:52553324ENST00000261839841756_7793491743.0DomainIQ 1
TgeneMYO5Cchr20:17550856chr15:52553324ENST00000261839841780_8063491743.0DomainIQ 2
TgeneMYO5Cchr20:17550856chr15:52553324ENST00000261839841807_8293491743.0DomainIQ 3
TgeneMYO5Cchr20:17550856chr15:52553324ENST00000261839841830_8543491743.0DomainIQ 4
TgeneMYO5Cchr20:17550856chr15:52553324ENST00000261839841855_8843491743.0DomainIQ 5
TgeneMYO5Cchr20:17550856chr15:52548917ENST00000261839941632_6544371743.0RegionActin-binding
TgeneMYO5Cchr20:17550856chr15:52553324ENST00000261839841632_6543491743.0RegionActin-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDSTNchr20:17550856chr15:52548917ENST00000246069+144_1531166.0DomainADF-H
HgeneDSTNchr20:17550856chr15:52553324ENST00000246069+144_1531166.0DomainADF-H
HgeneDSTNchr20:17550856chr15:52548917ENST00000246069+1430_341166.0MotifNuclear localization signal
HgeneDSTNchr20:17550856chr15:52553324ENST00000246069+1430_341166.0MotifNuclear localization signal
TgeneMYO5Cchr20:17550856chr15:52548917ENST0000026183994167_7534371743.0DomainMyosin motor
TgeneMYO5Cchr20:17550856chr15:52548917ENST000002618399418_624371743.0DomainMyosin N-terminal SH3-like
TgeneMYO5Cchr20:17550856chr15:52553324ENST0000026183984167_7533491743.0DomainMyosin motor
TgeneMYO5Cchr20:17550856chr15:52553324ENST000002618398418_623491743.0DomainMyosin N-terminal SH3-like
TgeneMYO5Cchr20:17550856chr15:52548917ENST00000261839941161_1684371743.0Nucleotide bindingATP
TgeneMYO5Cchr20:17550856chr15:52553324ENST00000261839841161_1683491743.0Nucleotide bindingATP


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Fusion Gene Sequence for DSTN-MYO5C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24311_24311_1_DSTN-MYO5C_DSTN_chr20_17550856_ENST00000246069_MYO5C_chr15_52548917_ENST00000443683_length(transcript)=1833nt_BP=349nt
TTCTAGCCTCCTGCAGACCAGAGAGGACGCACCCCCACCCCTAAACACTTTCTGGTGAGGCGGACCCTGCCCCGCAGCCTTCAGCAGATG
AGGGAAGCTCCCCTCCGAGACTCTGGATAGCCGCCGGGGGGGCGTTGCCTGGCCGGCTGGTTGCGTAGCAACGGCAGGCGGTGCGTGACG
TGCGCAGCCGCGTTCCGTCCTGAGGCGCGCCCGCCCCGGGGTAAGCTCGCGCCGCCGCGTCAGCTCAGCGCTGGGTCTCTCGGTCCCGCA
GCCGTGAGGAGGACGGTCTGCATACTCGCTGCCCGCCGGCTCCCTCCCCCGCGTCCCTGCGACCGCCGCGGCGAAGATGTTTTGAAACCT
TTGATGTGAACAGCTTTGAACAATTTTGCATCAATTACGCTAATGAAAAACTGCAACAACAGTTTAACATGCATGTCTTCAAACTGGAAC
AAGAAGAATACATGAAGGAAGATATACCTTGGACGCTGATAGATTTTTATGACAATCAACCAGTTATTGACCTGATTGAAGCAAAAATGG
GAATTCTGGAGTTACTGGATGAAGAATGTTTGTTACCACATGGAACTGATGAAAACTGGCTTCAAAAGCTGTATAATAATTTTGTCAACA
GGAACCCTTTGTTTGAAAAGCCTAGAATGTCAAACACATCCTTTGTCATCCAGCACTTTGCTGATAAGGTAGAGTATAAATGTGAAGGTT
TCCTGGAGAAAAACAGAGACACCGTCTATGACATGCTGGTTGAAATCCTGAGAGCAAGCAAGTTTCATCTCTGTGCCAACTTTTTTCAAG
AAAATCCAACTCCTCCTTCTCCTTTTGGTTCAATGATTACAGTTAAATCTGCAAAGCAAGTCATCAAGCCAAACAGCAAGCATTTCCGGA
CCACAGTTGGGAGCAAGTTCCGCAGCTCTCTGTACTTGCTCATGGAGACCCTCAATGCGACGACGCCCCACTACGTTCGATGCATCAAGC
CAAATGATGAGAAGTTACCCTTTGAATTTGACTCCAAAAGAATTGTTCAGCAGCTGCGAGCCTGCGGCGTTTTAGAAACGATTCGCATTA
GTGCACAGAGCTACCCTTCCAGGTGGACATACATCGAGTTCTACAGTCGCTACGGCATTCTCATGACCAAGCAAGAGCTTTCCTTCAGCG
ATAAAAAGGAGGTGTGCAAGGTGGTTTTACACAGACTCATCCAGGATTCTAATCAGTACCAGTTTGGTAAAACCAAAATTTTCTTCAGAG
CAGGACAAGTGGCTTATTTAGAGAAACTTCGATTGGATAAACTGAGGCAGAGTTGTGTTATGGTACAAAAGCACATGCGTGGCTGGCTCC
AGAGGAAAAAATTCCTCCGAGAGAGACGAGCCGCCCTGATAATCCAGCAGTACTTCCGGGGTCAGCAAACTGTGAGAACAAAGAAAACCA
TGGGCTGGTGGAGAAGCTGACTAGCCTGGCTGCTCTTCGAGCTGGGGATGTGGAAAAGATTCAGAAGCTGGAAGCAGAACTAGAAAAAGC
AGCCACTCACAGGCGAAATTACGAGGAGAAGGGGAAGAGATACAGGGATGCTGTGGAAGAGAAATTGGCAAAGCTTCAGAAGCATAATTC
AGAACTGGAAACACAGAAAGAACAAATACAGCTGAAGCTTCAAGAGAAGACTGAAGAGTTAAAAGAAAAAATGGACAACCTCACCAAGCA
GCTCTTTGATGATGTACAAAAGGAAGAACGGCAAAGAATGCTTCTTGAAAAAAGTTTTGAACTGAAAACACAAGACTATGAGAAGCAGAT

>24311_24311_1_DSTN-MYO5C_DSTN_chr20_17550856_ENST00000246069_MYO5C_chr15_52548917_ENST00000443683_length(amino acids)=390AA_BP=21
MHTRCPPAPSPASLRPPRRRCFETFDVNSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAKMGILELL
DEECLLPHGTDENWLQKLYNNFVNRNPLFEKPRMSNTSFVIQHFADKVEYKCEGFLEKNRDTVYDMLVEILRASKFHLCANFFQENPTPP
SPFGSMITVKSAKQVIKPNSKHFRTTVGSKFRSSLYLLMETLNATTPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYP
SRWTYIEFYSRYGILMTKQELSFSDKKEVCKVVLHRLIQDSNQYQFGKTKIFFRAGQVAYLEKLRLDKLRQSCVMVQKHMRGWLQRKKFL

--------------------------------------------------------------
>24311_24311_2_DSTN-MYO5C_DSTN_chr20_17550856_ENST00000246069_MYO5C_chr15_52553324_ENST00000261839_length(transcript)=6111nt_BP=349nt
TTCTAGCCTCCTGCAGACCAGAGAGGACGCACCCCCACCCCTAAACACTTTCTGGTGAGGCGGACCCTGCCCCGCAGCCTTCAGCAGATG
AGGGAAGCTCCCCTCCGAGACTCTGGATAGCCGCCGGGGGGGCGTTGCCTGGCCGGCTGGTTGCGTAGCAACGGCAGGCGGTGCGTGACG
TGCGCAGCCGCGTTCCGTCCTGAGGCGCGCCCGCCCCGGGGTAAGCTCGCGCCGCCGCGTCAGCTCAGCGCTGGGTCTCTCGGTCCCGCA
GCCGTGAGGAGGACGGTCTGCATACTCGCTGCCCGCCGGCTCCCTCCCCCGCGTCCCTGCGACCGCCGCGGCGAAGATGGAGGATGACAG
TCACCTGAAGGTGTTCTGTGAGCTCCTGGGCCTGGAGAGTGGCAGAGTTGCTCAGTGGCTGTGCAATCGCAAAATCGTCACAAGCTCTGA
GACGGTGGTAAAACCCATGACCAGGCCTCAGGCTGTCAACGCCAGGGATGCACTGGCCAAAAAGATCTATGCTCACCTGTTCGACTTCAT
TGTGGAGAGAATTAACCAAGCGTTGCAGTTTTCAGGCAAGCAGCACACTTTTATTGGTGTTTTGGACATTTATGGTTTTGAAACCTTTGA
TGTGAACAGCTTTGAACAATTTTGCATCAATTACGCTAATGAAAAACTGCAACAACAGTTTAACATGCATGTCTTCAAACTGGAACAAGA
AGAATACATGAAGGAAGATATACCTTGGACGCTGATAGATTTTTATGACAATCAACCAGTTATTGACCTGATTGAAGCAAAAATGGGAAT
TCTGGAGTTACTGGATGAAGAATGTTTGTTACCACATGGAACTGATGAAAACTGGCTTCAAAAGCTGTATAATAATTTTGTCAACAGGAA
CCCTTTGTTTGAAAAGCCTAGAATGTCAAACACATCCTTTGTCATCCAGCACTTTGCTGATAAGGTAGAGTATAAATGTGAAGGTTTCCT
GGAGAAAAACAGAGACACCGTCTATGACATGCTGGTTGAAATCCTGAGAGCAAGCAAGTTTCATCTCTGTGCCAACTTTTTTCAAGAAAA
TCCAACTCCTCCTTCTCCTTTTGGTTCAATGATTACAGTTAAATCTGCAAAGCAAGTCATCAAGCCAAACAGCAAGCATTTCCGGACCAC
AGTTGGGAGCAAGTTCCGCAGCTCTCTGTACTTGCTCATGGAGACCCTCAATGCGACGACGCCCCACTACGTTCGATGCATCAAGCCAAA
TGATGAGAAGTTACCCTTTGAATTTGACTCCAAAAGAATTGTTCAGCAGCTGCGAGCCTGCGGCGTTTTAGAAACGATTCGCATTAGTGC
ACAGAGCTACCCTTCCAGGTGGACATACATCGAGTTCTACAGTCGCTACGGCATTCTCATGACCAAGCAAGAGCTTTCCTTCAGCGATAA
AAAGGAGGTGTGCAAGGTGGTTTTACACAGACTCATCCAGGATTCTAATCAGTACCAGTTTGGTAAAACCAAAATTTTCTTCAGAGCAGG
ACAAGTGGCTTATTTAGAGAAACTTCGATTGGATAAACTGAGGCAGAGTTGTGTTATGGTACAAAAGCACATGCGTGGCTGGCTCCAGAG
GAAAAAATTCCTCCGAGAGAGACGAGCCGCCCTGATAATCCAGCAGTACTTCCGGGGTCAGCAAACTGTGAGGAAAGCTATTACTGCAGT
GGCCTTAAAAGAAGCTTGGGCAGCCATAATCATTCAGAAGCACTGCCGCGGGTATCTTGTTCGCAGCCTGTATCAGTTGATTCGCATGGC
CACCATCACAATGCAGGCCTACAGCCGAGGATTCCTGGCAAGGAGGAGGTATCGAAAGATGCTGGAGGAACATAAGGCTGTGATCCTACA
GAAATACGCACGGGCGTGGCTGGCCAGACGCAGATTCCAGAGTATCCGACGATTCGTGCTTAATATTCAGCTTACTTACAGGGTCCAGCG
TTTGCAGAAAAAGTTGGAAGATCAGAACAAAGAAAACCATGGGCTGGTGGAGAAGCTGACTAGCCTGGCTGCTCTTCGAGCTGGGGATGT
GGAAAAGATTCAGAAGCTGGAAGCAGAACTAGAAAAAGCAGCCACTCACAGGCGAAATTACGAGGAGAAGGGGAAGAGATACAGGGATGC
TGTGGAAGAGAAATTGGCAAAGCTTCAGAAGCATAATTCAGAACTGGAAACACAGAAAGAACAAATACAGCTGAAGCTTCAAGAGAAGAC
TGAAGAGTTAAAAGAAAAAATGGACAACCTCACCAAGCAGCTCTTTGATGATGTACAAAAGGAAGAACGGCAAAGAATGCTTCTTGAAAA
AAGTTTTGAACTGAAAACACAAGACTATGAGAAGCAGATTCAGTCTTTGAAAGAAGAAATTAAAGCTCTCAAGGATGAGAAGATGCAACT
CCAACACCTGGTGGAGGGGGAGCACGTCACTTCTGATGGCTTGAAGGCGGAAGTGGCCCGCCTGAGCAAGCAGGTCAAGACAATCTCTGA
GTTCGAAAAAGAGATAGAACTACTTCAGGCACAGAAGATAGATGTGGAGAAACATGTGCAGTCACAAAAACGGGAAATGAGAGAAAAGAT
GTCAGAGATCACCAAACAACTTCTCGAAAGCTATGACATTGAAGATGTAAGAAGCAGGCTCTCTGTGGAAGATCTGGAACATTTAAATGA
GGATGGAGAACTTTGGTTTGCTTATGAAGGACTAAAGAAAGCAACACGTGTTTTGGAGAGCCATTTCCAGTCTCAGAAGGATTGCTATGA
AAAGGAGATTGAAGCTTTGAACTTCAAAGTGGTGCATCTCAGTCAAGAAATCAACCACCTGCAGAAGTTATTCAGAGAAGAAAATGACAT
CAATGAAAGCATCCGTCATGAAGTTACCAGGCTAACATCAGAGAACATGATGATCCCAGACTTTAAACAGCAAATTTCAGAATTGGAGAA
ACAGAAGCAAGATCTTGAAATCCGCCTGAATGAACAAGCTGAGAAAATGAAAGGAAAACTAGAAGAATTGTCTAATCAGTTACATCGCAG
TCAAGAGGAGGAAGGAACACAAAGAAAGGCCTTGGAAGCCCAAAATGAAATACATACCAAAGAGAAGGAGAAGCTGATTGATAAGATTCA
AGAAATGCAGGAGGCCAGTGACCACTTGAAGAAACAATTTGAAACTGAAAGTGAAGTCAAGTGTAACTTCCGGCAGGAAGCATCCCGGCT
CACTTTGGAAAACAGGGATCTTGAAGAAGAATTAGACATGAAAGACAGAGTGATTAAAAAGCTACAAGATCAAGTCAAGACACTAAGCAA
GACAATTGGAAAAGCCAATGATGTGCACTCGTCCTCAGGACCCAAGGAGTACCTTGGAATGCTGCAATACAAGAGAGAAGACGAGGCCAA
GCTCATTCAGAACCTCATTCTTGACTTGAAGCCCCGTGGCGTGGTGGTGAACATGATCCCCGGGCTGCCGGCTCATATCCTGTTCATGTG
TGTGCGCTACGCAGACTCTCTGAATGATGCCAACATGCTGAAGTCCCTCATGAACAGCACCATTAATGGCATCAAGCAGGTGGTTAAGGA
ACATTTAGAAGACTTTGAAATGCTGTCCTTTTGGCTTTCCAACACTTGTCATTTTCTCAATTGCCTGAAGCAGTACAGCGGAGAAGAGGA
ATTCATGAAGCATAATAGTCCACAGCAGAATAAGAATTGCTTGAACAATTTTGACCTTTCAGAATACAGACAGATTCTCAGTGATGTGGC
TATACGAATATATCATCAATTTATTATCATAATGGAAAAGAATATCCAACCGATAATAGTTCCGGGAATGCTGGAGTATGAGAGCCTGCA
GGGCATTTCCGGCCTGAAGCCCACAGGCTTCCGGAAGCGCTCCTCTAGCATAGACGACACGGACGGCTACACCATGACCTCCGTCCTGCA
ACAGCTGAGCTACTTTTACACCACCATGTGCCAGAACGGCCTGGACCCCGAGCTTGTGAGGCAGGCGGTGAAGCAGCTCTTCTTCTTGAT
CGGGGCGGTCACGCTGAACAGCCTCTTCCTGCGCAAGGACATGTGCTCCTGCAGAAAAGGGATGCAGATCAGGTGCAATATCAGCTACTT
AGAAGAATGGCTTAAAGATAAGAACTTGCAGAACAGCTTAGCAAAGGAAACTTTGGAGCCCCTCTCTCAGGCAGCCTGGTTGCTTCAGGT
CAAGAAGACCACAGACAGTGATGCCAAGGAGATCTACGAACGCTGCACCTCACTGTCTGCTGTGCAGATCATAAAGATCCTTAATTCATA
CACACCTATAGATGACTTTGAGAAGAGAGTGACTCCATCCTTTGTTCGCAAAGTACAGGCTCTCCTAAATAGCCGGGAGGATTCATCACA
GCTGATGTTGGATACCAAATATCTCTTTCAAGTCACATTTCCTTTTACCCCCTCTCCACATGCTCTGGAAATGATTCAGATCCCCAGCAG
TTTCAAGCTAGGCTTTCTGAATAGGTTATAGCAGGAGAAAAAGTCAATGCACTTTTTCTTCAAAAGCTAAGTGAAGGTTCAATATGAGGG
ATGTGTTTTATTAATTGGCAGTGGAAATTGGAATGTGATTTAAGGAAGAAAACAGACTTTTCTCAAATGGACCACATCATCTCTCACTCA
CAGTGACAATGCTGCTCCTGTAATTTTGTAAGAATTCACACACACCAGCTGTATTTGGAAAAGCCATGTCTCACTCTCGAATCTCAGCTG
GTTTTCACTGAAATTCCTGGAGGGCTCATATTTTCTTCCACGTGCCTCTTGATCTGTTCTGTCTTGTGGCAGGGCTCTACCAGGAGGGAG
TGAGATCTGGGGACACAGTGGCTTCCAAGTTTTCTAAGGTTCATGTGAAACCTGAGTACATTTACAAAGCTGCAAGTGGATTCTAGTGCT
GAGTCTTCCAGGAAAAAATCCCGTTTGGCCACCGTGACCTGCCAAAAGTTCTCTTGCCCCATGCCTGCTGGGGACAGAAGGTTTTCATGA
ACTCTTTTTACTGAAAATGCCCTGCATTTAAAAATGTTTATTTTAGACCCTTCTAAATTTTTTTTTTTTTTTTTTTTTGAGACTCCGGAG
TCTCGCTCTATCGCCAGGCTGGAGTGTAGTGGCATGATCTCGGCTTATTGCAACCTCCGCTTCCTGGGTTCAAACAATTCTCCTGCCTCA
GCCTCCTGAGTAGCTGGGACTACAGGCACCTGCCACCACGCCCAGCTAATTTTTGTATTTTTAGTGGAGACAGGTTTCACCATGTTGGCC
AGGATGGCCTCGATCTCTTGACCTCGTGATCCGCCCACCTCAGCCTCCCAAAGTGCTAGGATTACAGGCGTGTGCCACCGCGCCCGGCTG
ACCCTTTTAATTTTTAAGAGTGTTCAATCCGAGATGAATCATTTGAAGTATTTTTATATGTATATCTATTTAAAACTAATATATTATTAA
AGCTTAATTGCCATGCCGTTTATCTTCTCTGAAAGAACTTCAAATCTTACCTGCCAACATATTCACCATAATTTTTTTATTTTTTAATAC
CTTTCATACAATAACTTTTTTAAAACAACCTCAGATTGAAAAAGCAACCTAAATTACTTTCGCTCTCTAATCAGCATTTCAATGTATTTA
TTTTTAAATTTTCTCAAAAAGTAACTAAAAAATTGTGTCGGACCCTACTTTTGAGAAATCTACGTTTCCCAAGTTTTATGGGAACTGGCT
ATTCCTTGTCCCGGCACACCTTCTCATTCCTTCCTTTCAGAGCCTAAAACCTCATTTGATAAGCACTCCTAGTCTCTGGCCTGTGGATCC
AGTGCTATTCTGTCACCAACCTAAGAATCCCAATTGCACCTTCTGTTTCTGACAGTCACAGGTGACAGCTGTGATTCTATAATACAGACT
GGTGTCTTAGAGGTAGGAATAATACATGATTATGAAGCATCACCCTGCTAATACATAATAATGTCTTTTTATATTATAAGTGATTGAGTT

>24311_24311_2_DSTN-MYO5C_DSTN_chr20_17550856_ENST00000246069_MYO5C_chr15_52553324_ENST00000261839_length(amino acids)=1410AA_BP=17
MPAGSLPRVPATAAAKMEDDSHLKVFCELLGLESGRVAQWLCNRKIVTSSETVVKPMTRPQAVNARDALAKKIYAHLFDFIVERINQALQ
FSGKQHTFIGVLDIYGFETFDVNSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAKMGILELLDEECL
LPHGTDENWLQKLYNNFVNRNPLFEKPRMSNTSFVIQHFADKVEYKCEGFLEKNRDTVYDMLVEILRASKFHLCANFFQENPTPPSPFGS
MITVKSAKQVIKPNSKHFRTTVGSKFRSSLYLLMETLNATTPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTY
IEFYSRYGILMTKQELSFSDKKEVCKVVLHRLIQDSNQYQFGKTKIFFRAGQVAYLEKLRLDKLRQSCVMVQKHMRGWLQRKKFLRERRA
ALIIQQYFRGQQTVRKAITAVALKEAWAAIIIQKHCRGYLVRSLYQLIRMATITMQAYSRGFLARRRYRKMLEEHKAVILQKYARAWLAR
RRFQSIRRFVLNIQLTYRVQRLQKKLEDQNKENHGLVEKLTSLAALRAGDVEKIQKLEAELEKAATHRRNYEEKGKRYRDAVEEKLAKLQ
KHNSELETQKEQIQLKLQEKTEELKEKMDNLTKQLFDDVQKEERQRMLLEKSFELKTQDYEKQIQSLKEEIKALKDEKMQLQHLVEGEHV
TSDGLKAEVARLSKQVKTISEFEKEIELLQAQKIDVEKHVQSQKREMREKMSEITKQLLESYDIEDVRSRLSVEDLEHLNEDGELWFAYE
GLKKATRVLESHFQSQKDCYEKEIEALNFKVVHLSQEINHLQKLFREENDINESIRHEVTRLTSENMMIPDFKQQISELEKQKQDLEIRL
NEQAEKMKGKLEELSNQLHRSQEEEGTQRKALEAQNEIHTKEKEKLIDKIQEMQEASDHLKKQFETESEVKCNFRQEASRLTLENRDLEE
ELDMKDRVIKKLQDQVKTLSKTIGKANDVHSSSGPKEYLGMLQYKREDEAKLIQNLILDLKPRGVVVNMIPGLPAHILFMCVRYADSLND
ANMLKSLMNSTINGIKQVVKEHLEDFEMLSFWLSNTCHFLNCLKQYSGEEEFMKHNSPQQNKNCLNNFDLSEYRQILSDVAIRIYHQFII
IMEKNIQPIIVPGMLEYESLQGISGLKPTGFRKRSSSIDDTDGYTMTSVLQQLSYFYTTMCQNGLDPELVRQAVKQLFFLIGAVTLNSLF
LRKDMCSCRKGMQIRCNISYLEEWLKDKNLQNSLAKETLEPLSQAAWLLQVKKTTDSDAKEIYERCTSLSAVQIIKILNSYTPIDDFEKR

--------------------------------------------------------------
>24311_24311_3_DSTN-MYO5C_DSTN_chr20_17550856_ENST00000246069_MYO5C_chr15_52553324_ENST00000443683_length(transcript)=2059nt_BP=349nt
TTCTAGCCTCCTGCAGACCAGAGAGGACGCACCCCCACCCCTAAACACTTTCTGGTGAGGCGGACCCTGCCCCGCAGCCTTCAGCAGATG
AGGGAAGCTCCCCTCCGAGACTCTGGATAGCCGCCGGGGGGGCGTTGCCTGGCCGGCTGGTTGCGTAGCAACGGCAGGCGGTGCGTGACG
TGCGCAGCCGCGTTCCGTCCTGAGGCGCGCCCGCCCCGGGGTAAGCTCGCGCCGCCGCGTCAGCTCAGCGCTGGGTCTCTCGGTCCCGCA
GCCGTGAGGAGGACGGTCTGCATACTCGCTGCCCGCCGGCTCCCTCCCCCGCGTCCCTGCGACCGCCGCGGCGAAGATGGAGGATGACAG
TCACCTGAAGGTGTTCTGTGAGCTCCTGGGCCTGGAGAGTGGCAGAGTTGCTCAGTGGCTGTGCAATCGCAAAATCGTCACAAGCTCTGA
GACGGTGGTAAAACCCATGACCAGGCCTCAGGCTGTCAACGCCAGGGATGCACTGGCCAAAAAGATCTATGCTCACCTGTTCGACTTCAT
TGTGGAGAGAATTAACCAAGCGTTGCAGTTTTCAGTTTTGAAACCTTTGATGTGAACAGCTTTGAACAATTTTGCATCAATTACGCTAAT
GAAAAACTGCAACAACAGTTTAACATGCATGTCTTCAAACTGGAACAAGAAGAATACATGAAGGAAGATATACCTTGGACGCTGATAGAT
TTTTATGACAATCAACCAGTTATTGACCTGATTGAAGCAAAAATGGGAATTCTGGAGTTACTGGATGAAGAATGTTTGTTACCACATGGA
ACTGATGAAAACTGGCTTCAAAAGCTGTATAATAATTTTGTCAACAGGAACCCTTTGTTTGAAAAGCCTAGAATGTCAAACACATCCTTT
GTCATCCAGCACTTTGCTGATAAGGTAGAGTATAAATGTGAAGGTTTCCTGGAGAAAAACAGAGACACCGTCTATGACATGCTGGTTGAA
ATCCTGAGAGCAAGCAAGTTTCATCTCTGTGCCAACTTTTTTCAAGAAAATCCAACTCCTCCTTCTCCTTTTGGTTCAATGATTACAGTT
AAATCTGCAAAGCAAGTCATCAAGCCAAACAGCAAGCATTTCCGGACCACAGTTGGGAGCAAGTTCCGCAGCTCTCTGTACTTGCTCATG
GAGACCCTCAATGCGACGACGCCCCACTACGTTCGATGCATCAAGCCAAATGATGAGAAGTTACCCTTTGAATTTGACTCCAAAAGAATT
GTTCAGCAGCTGCGAGCCTGCGGCGTTTTAGAAACGATTCGCATTAGTGCACAGAGCTACCCTTCCAGGTGGACATACATCGAGTTCTAC
AGTCGCTACGGCATTCTCATGACCAAGCAAGAGCTTTCCTTCAGCGATAAAAAGGAGGTGTGCAAGGTGGTTTTACACAGACTCATCCAG
GATTCTAATCAGTACCAGTTTGGTAAAACCAAAATTTTCTTCAGAGCAGGACAAGTGGCTTATTTAGAGAAACTTCGATTGGATAAACTG
AGGCAGAGTTGTGTTATGGTACAAAAGCACATGCGTGGCTGGCTCCAGAGGAAAAAATTCCTCCGAGAGAGACGAGCCGCCCTGATAATC
CAGCAGTACTTCCGGGGTCAGCAAACTGTGAGAACAAAGAAAACCATGGGCTGGTGGAGAAGCTGACTAGCCTGGCTGCTCTTCGAGCTG
GGGATGTGGAAAAGATTCAGAAGCTGGAAGCAGAACTAGAAAAAGCAGCCACTCACAGGCGAAATTACGAGGAGAAGGGGAAGAGATACA
GGGATGCTGTGGAAGAGAAATTGGCAAAGCTTCAGAAGCATAATTCAGAACTGGAAACACAGAAAGAACAAATACAGCTGAAGCTTCAAG
AGAAGACTGAAGAGTTAAAAGAAAAAATGGACAACCTCACCAAGCAGCTCTTTGATGATGTACAAAAGGAAGAACGGCAAAGAATGCTTC

>24311_24311_3_DSTN-MYO5C_DSTN_chr20_17550856_ENST00000246069_MYO5C_chr15_52553324_ENST00000443683_length(amino acids)=349AA_BP=
MQQQFNMHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAKMGILELLDEECLLPHGTDENWLQKLYNNFVNRNPLFEKPRMSNTSFVI
QHFADKVEYKCEGFLEKNRDTVYDMLVEILRASKFHLCANFFQENPTPPSPFGSMITVKSAKQVIKPNSKHFRTTVGSKFRSSLYLLMET
LNATTPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYIEFYSRYGILMTKQELSFSDKKEVCKVVLHRLIQDS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DSTN-MYO5C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DSTN-MYO5C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DSTN-MYO5C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDSTNC0018801Heart failure1CTD_human
HgeneDSTNC0018802Congestive heart failure1CTD_human
HgeneDSTNC0023212Left-Sided Heart Failure1CTD_human
HgeneDSTNC0235527Heart Failure, Right-Sided1CTD_human
HgeneDSTNC0600519Ventricular Remodeling1CTD_human
HgeneDSTNC0600520Left Ventricle Remodeling1CTD_human
HgeneDSTNC1959583Myocardial Failure1CTD_human
HgeneDSTNC1961112Heart Decompensation1CTD_human
TgeneC0013146Drug abuse1CTD_human
TgeneC0013170Drug habituation1CTD_human
TgeneC0013222Drug Use Disorders1CTD_human
TgeneC0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgeneC0038580Substance Dependence1CTD_human
TgeneC0038586Substance Use Disorders1CTD_human
TgeneC0236969Substance-Related Disorders1CTD_human
TgeneC0740858Substance abuse problem1CTD_human
TgeneC1510472Drug Dependence1CTD_human
TgeneC4316881Prescription Drug Abuse1CTD_human