Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CPSF6-COL9A1 (FusionGDB2 ID:HG11052TG1297)

Fusion Gene Summary for CPSF6-COL9A1

check button Fusion gene summary
Fusion gene informationFusion gene name: CPSF6-COL9A1
Fusion gene ID: hg11052tg1297
HgeneTgene
Gene symbol

CPSF6

COL9A1

Gene ID

11052

1297

Gene namecleavage and polyadenylation specific factor 6collagen type IX alpha 1 chain
SynonymsCFIM|CFIM68|CFIM72|HPBRII-4|HPBRII-7DJ149L1.1.2|EDM6|MED|STL4
Cytomap('CPSF6')('COL9A1')

12q15

6q13

Type of geneprotein-codingprotein-coding
Descriptioncleavage and polyadenylation specificity factor subunit 6CPSF 68 kDa subunitcleavage and polyadenylation specific factor 6, 68kDacleavage and polyadenylation specificity factor 68 kDa subunitcleavage factor Im complex 68 kDa subunitpre-mRNA cleavage collagen alpha-1(IX) chainalpha-1(IX) collagen chaincartilage-specific short collagencollagen IX, alpha-1 polypeptidecollagen, type IX, alpha 1
Modification date2020031320200313
UniProtAcc.

P20849

Ensembl transtripts involved in fusion geneENST00000550987, ENST00000266679, 
ENST00000435070, ENST00000456847, 
ENST00000551516, 
Fusion gene scores* DoF score69 X 12 X 19=157327 X 5 X 4=140
# samples 718
** MAII scorelog2(71/15732*10)=-4.46973925655087
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/140*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CPSF6 [Title/Abstract] AND COL9A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCPSF6(69633486)-COL9A1(70926784), # samples:4
Anticipated loss of major functional domain due to fusion event.CPSF6-COL9A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CPSF6-COL9A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CPSF6-COL9A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CPSF6-COL9A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CPSF6-COL9A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCPSF6

GO:0006397

mRNA processing

14690600

HgeneCPSF6

GO:0051262

protein tetramerization

20695905

HgeneCPSF6

GO:0051290

protein heterotetramerization

23187700

HgeneCPSF6

GO:1990120

messenger ribonucleoprotein complex assembly

29276085


check buttonFusion gene breakpoints across CPSF6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across COL9A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-FX-A2QS-01ACPSF6chr12

69633486

-COL9A1chr6

70926784

-
ChimerDB4SARCTCGA-FX-A2QS-01ACPSF6chr12

69633486

+COL9A1chr6

70926784

-
ChimerDB4SARCTCGA-FX-A2QSCPSF6chr12

69633486

+COL9A1chr6

70926784

-


Top

Fusion Gene ORF analysis for CPSF6-COL9A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000550987ENST00000320755CPSF6chr12

69633486

+COL9A1chr6

70926784

-
3UTR-3CDSENST00000550987ENST00000357250CPSF6chr12

69633486

+COL9A1chr6

70926784

-
3UTR-3CDSENST00000550987ENST00000370499CPSF6chr12

69633486

+COL9A1chr6

70926784

-
3UTR-5UTRENST00000550987ENST00000489611CPSF6chr12

69633486

+COL9A1chr6

70926784

-
3UTR-intronENST00000550987ENST00000370496CPSF6chr12

69633486

+COL9A1chr6

70926784

-
5CDS-5UTRENST00000266679ENST00000489611CPSF6chr12

69633486

+COL9A1chr6

70926784

-
5CDS-5UTRENST00000435070ENST00000489611CPSF6chr12

69633486

+COL9A1chr6

70926784

-
5CDS-5UTRENST00000456847ENST00000489611CPSF6chr12

69633486

+COL9A1chr6

70926784

-
5CDS-5UTRENST00000551516ENST00000489611CPSF6chr12

69633486

+COL9A1chr6

70926784

-
5CDS-intronENST00000266679ENST00000370496CPSF6chr12

69633486

+COL9A1chr6

70926784

-
5CDS-intronENST00000435070ENST00000370496CPSF6chr12

69633486

+COL9A1chr6

70926784

-
5CDS-intronENST00000456847ENST00000370496CPSF6chr12

69633486

+COL9A1chr6

70926784

-
5CDS-intronENST00000551516ENST00000370496CPSF6chr12

69633486

+COL9A1chr6

70926784

-
Frame-shiftENST00000266679ENST00000320755CPSF6chr12

69633486

+COL9A1chr6

70926784

-
Frame-shiftENST00000435070ENST00000320755CPSF6chr12

69633486

+COL9A1chr6

70926784

-
Frame-shiftENST00000456847ENST00000320755CPSF6chr12

69633486

+COL9A1chr6

70926784

-
Frame-shiftENST00000551516ENST00000320755CPSF6chr12

69633486

+COL9A1chr6

70926784

-
In-frameENST00000266679ENST00000357250CPSF6chr12

69633486

+COL9A1chr6

70926784

-
In-frameENST00000266679ENST00000370499CPSF6chr12

69633486

+COL9A1chr6

70926784

-
In-frameENST00000435070ENST00000357250CPSF6chr12

69633486

+COL9A1chr6

70926784

-
In-frameENST00000435070ENST00000370499CPSF6chr12

69633486

+COL9A1chr6

70926784

-
In-frameENST00000456847ENST00000357250CPSF6chr12

69633486

+COL9A1chr6

70926784

-
In-frameENST00000456847ENST00000370499CPSF6chr12

69633486

+COL9A1chr6

70926784

-
In-frameENST00000551516ENST00000357250CPSF6chr12

69633486

+COL9A1chr6

70926784

-
In-frameENST00000551516ENST00000370499CPSF6chr12

69633486

+COL9A1chr6

70926784

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000435070CPSF6chr1269633486+ENST00000357250COL9A1chr670926784-219117043813999
ENST00000435070CPSF6chr1269633486+ENST00000370499COL9A1chr670926784-12111703312110
ENST00000456847CPSF6chr1269633486+ENST00000357250COL9A1chr670926784-21281073757699
ENST00000456847CPSF6chr1269633486+ENST00000370499COL9A1chr670926784-11481073757699
ENST00000266679CPSF6chr1269633486+ENST00000357250COL9A1chr670926784-2112913596099
ENST00000266679CPSF6chr1269633486+ENST00000370499COL9A1chr670926784-1132913596099
ENST00000551516CPSF6chr1269633486+ENST00000357250COL9A1chr670926784-2086653333499
ENST00000551516CPSF6chr1269633486+ENST00000370499COL9A1chr670926784-1106653333499

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000435070ENST00000357250CPSF6chr1269633486+COL9A1chr670926784-0.070489470.9295106
ENST00000435070ENST00000370499CPSF6chr1269633486+COL9A1chr670926784-0.066966730.9330332
ENST00000456847ENST00000357250CPSF6chr1269633486+COL9A1chr670926784-0.0907824860.9092175
ENST00000456847ENST00000370499CPSF6chr1269633486+COL9A1chr670926784-0.0874730350.9125269
ENST00000266679ENST00000357250CPSF6chr1269633486+COL9A1chr670926784-0.0494363050.9505637
ENST00000266679ENST00000370499CPSF6chr1269633486+COL9A1chr670926784-0.0873372260.91266274
ENST00000551516ENST00000357250CPSF6chr1269633486+COL9A1chr670926784-0.169857130.8301429
ENST00000551516ENST00000370499CPSF6chr1269633486+COL9A1chr670926784-0.1862070.81379294

Top

Fusion Genomic Features for CPSF6-COL9A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for CPSF6-COL9A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69633486/chr6:70926784)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.COL9A1

P20849

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Structural component of hyaline cartilage and vitreous of the eye.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003207553032655_712617679.0DomainNote=Collagen-like 7
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003207553032713_755617679.0DomainNote=Collagen-like 8
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003207553032790_847617679.0DomainNote=Collagen-like 9
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003207553032848_899617679.0DomainNote=Collagen-like 10
TgeneCOL9A1chr12:69633486chr6:70926784ENST00000370496011269_3240329.0DomainNote=Collagen-like 1
TgeneCOL9A1chr12:69633486chr6:70926784ENST00000370496011325_3560329.0DomainNote=Collagen-like 2
TgeneCOL9A1chr12:69633486chr6:70926784ENST00000370496011358_4030329.0DomainNote=Collagen-like 3
TgeneCOL9A1chr12:69633486chr6:70926784ENST00000370496011416_4720329.0DomainNote=Collagen-like 4
TgeneCOL9A1chr12:69633486chr6:70926784ENST00000370496011473_5160329.0DomainNote=Collagen-like 5
TgeneCOL9A1chr12:69633486chr6:70926784ENST0000037049601150_2440329.0DomainNote=Laminin G-like
TgeneCOL9A1chr12:69633486chr6:70926784ENST00000370496011587_6430329.0DomainNote=Collagen-like 6
TgeneCOL9A1chr12:69633486chr6:70926784ENST00000370496011655_7120329.0DomainNote=Collagen-like 7
TgeneCOL9A1chr12:69633486chr6:70926784ENST00000370496011713_7550329.0DomainNote=Collagen-like 8
TgeneCOL9A1chr12:69633486chr6:70926784ENST00000370496011790_8470329.0DomainNote=Collagen-like 9
TgeneCOL9A1chr12:69633486chr6:70926784ENST00000370496011848_8990329.0DomainNote=Collagen-like 10
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003207553032757_786617679.0RegionNote=Nonhelical region (NC2)
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003207553032787_901617679.0RegionNote=Triple-helical region (COL1)
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003207553032902_921617679.0RegionNote=Nonhelical region (NC1)
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003572503638902_921860922.0RegionNote=Nonhelical region (NC1)
TgeneCOL9A1chr12:69633486chr6:70926784ENST0000037049601124_2680329.0RegionNote=Nonhelical region (NC4)
TgeneCOL9A1chr12:69633486chr6:70926784ENST00000370496011269_4050329.0RegionNote=Triple-helical region (COL3)
TgeneCOL9A1chr12:69633486chr6:70926784ENST00000370496011406_4170329.0RegionNote=Nonhelical region (NC3)
TgeneCOL9A1chr12:69633486chr6:70926784ENST00000370496011418_7560329.0RegionNote=Triple-helical region (COL2)
TgeneCOL9A1chr12:69633486chr6:70926784ENST00000370496011757_7860329.0RegionNote=Nonhelical region (NC2)
TgeneCOL9A1chr12:69633486chr6:70926784ENST00000370496011787_9010329.0RegionNote=Triple-helical region (COL1)
TgeneCOL9A1chr12:69633486chr6:70926784ENST00000370496011902_9210329.0RegionNote=Nonhelical region (NC1)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCPSF6chr12:69633486chr6:70926784ENST00000266679+111208_39820701.3333333333334Compositional biasNote=Pro-rich
HgeneCPSF6chr12:69633486chr6:70926784ENST00000266679+111490_55120701.3333333333334Compositional biasNote=Arg-rich
HgeneCPSF6chr12:69633486chr6:70926784ENST00000435070+110208_398202111.0Compositional biasNote=Pro-rich
HgeneCPSF6chr12:69633486chr6:70926784ENST00000435070+110490_551202111.0Compositional biasNote=Arg-rich
HgeneCPSF6chr12:69633486chr6:70926784ENST00000266679+111202_20620701.3333333333334MotifGAR
HgeneCPSF6chr12:69633486chr6:70926784ENST00000435070+110202_206202111.0MotifGAR
HgeneCPSF6chr12:69633486chr6:70926784ENST00000266679+111358_55120701.3333333333334Region(Microbial infection) Binds to HIV-1 capsid protein p24 (CA)
HgeneCPSF6chr12:69633486chr6:70926784ENST00000266679+111404_55120701.3333333333334RegionSufficient for nuclear speckle localization
HgeneCPSF6chr12:69633486chr6:70926784ENST00000266679+111405_55120701.3333333333334RegionNecessary for RNA-binding
HgeneCPSF6chr12:69633486chr6:70926784ENST00000266679+111510_55120701.3333333333334RegionSufficient for nuclear targeting
HgeneCPSF6chr12:69633486chr6:70926784ENST00000266679+11181_16120701.3333333333334RegionNecessary for nuclear paraspeckles localization
HgeneCPSF6chr12:69633486chr6:70926784ENST00000435070+110358_551202111.0Region(Microbial infection) Binds to HIV-1 capsid protein p24 (CA)
HgeneCPSF6chr12:69633486chr6:70926784ENST00000435070+110404_551202111.0RegionSufficient for nuclear speckle localization
HgeneCPSF6chr12:69633486chr6:70926784ENST00000435070+110405_551202111.0RegionNecessary for RNA-binding
HgeneCPSF6chr12:69633486chr6:70926784ENST00000435070+110510_551202111.0RegionSufficient for nuclear targeting
HgeneCPSF6chr12:69633486chr6:70926784ENST00000435070+11081_161202111.0RegionNecessary for nuclear paraspeckles localization
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003207553032269_324617679.0DomainNote=Collagen-like 1
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003207553032325_356617679.0DomainNote=Collagen-like 2
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003207553032358_403617679.0DomainNote=Collagen-like 3
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003207553032416_472617679.0DomainNote=Collagen-like 4
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003207553032473_516617679.0DomainNote=Collagen-like 5
TgeneCOL9A1chr12:69633486chr6:70926784ENST00000320755303250_244617679.0DomainNote=Laminin G-like
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003207553032587_643617679.0DomainNote=Collagen-like 6
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003572503638269_324860922.0DomainNote=Collagen-like 1
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003572503638325_356860922.0DomainNote=Collagen-like 2
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003572503638358_403860922.0DomainNote=Collagen-like 3
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003572503638416_472860922.0DomainNote=Collagen-like 4
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003572503638473_516860922.0DomainNote=Collagen-like 5
TgeneCOL9A1chr12:69633486chr6:70926784ENST00000357250363850_244860922.0DomainNote=Laminin G-like
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003572503638587_643860922.0DomainNote=Collagen-like 6
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003572503638655_712860922.0DomainNote=Collagen-like 7
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003572503638713_755860922.0DomainNote=Collagen-like 8
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003572503638790_847860922.0DomainNote=Collagen-like 9
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003572503638848_899860922.0DomainNote=Collagen-like 10
TgeneCOL9A1chr12:69633486chr6:70926784ENST00000320755303224_268617679.0RegionNote=Nonhelical region (NC4)
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003207553032269_405617679.0RegionNote=Triple-helical region (COL3)
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003207553032406_417617679.0RegionNote=Nonhelical region (NC3)
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003207553032418_756617679.0RegionNote=Triple-helical region (COL2)
TgeneCOL9A1chr12:69633486chr6:70926784ENST00000357250363824_268860922.0RegionNote=Nonhelical region (NC4)
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003572503638269_405860922.0RegionNote=Triple-helical region (COL3)
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003572503638406_417860922.0RegionNote=Nonhelical region (NC3)
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003572503638418_756860922.0RegionNote=Triple-helical region (COL2)
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003572503638757_786860922.0RegionNote=Nonhelical region (NC2)
TgeneCOL9A1chr12:69633486chr6:70926784ENST000003572503638787_901860922.0RegionNote=Triple-helical region (COL1)


Top

Fusion Gene Sequence for CPSF6-COL9A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>19146_19146_1_CPSF6-COL9A1_CPSF6_chr12_69633486_ENST00000266679_COL9A1_chr6_70926784_ENST00000357250_length(transcript)=2112nt_BP=91nt
CGGCGGCGGCGGCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCA
GGTGACCCAGGCCCTGCCAGCTATGGCAGAAATGGCCGAGACGGTGAGCGAGGCCCCCCAGGGGTGGCAGGAATTCCTGGAGTGCCTGGA
CCCCCGGGACCTCCTGGGCTTCCCGGTTTCTGTGAGCCAGCCTCCTGCACCATGCAGGCTGGTCAGCGAGCATTTAACAAAGGGCCTGAC
CCTTGAAAGGCTTACTGCTGCATGGCTGTCTGCATGAACCACGCCTGGTGAAGGAGCCTGGGTGAGAAACACCATCCAAAGCTGGGGCAA
AGATGATTACCTTCAGCATGATTACAATGTATTACCTTCAGTATGATTACAGAAGTCCTACTTGACAATCACATATAGAAGAACGGTGCT
ATTCAGTAAGTTCTCTTTCCTTTCCCTTGGAGGGAAGACAGCAGAGTCATCAGTTAAAAAAAAAAAAAGAAAACCAAACACCTCCCTTGA
ATAAATTTATACTCCTGTTCCCAGGATCTTGAGCTTTAGTGTGCTATACCTATGTGTCTTATCGTGGGCCACTGTGCCAATAAACAAAAA
CAACTGTTTGGTTTACCTCAGTTGCAGTAGTTATTTTCATTTAGAAGTTGTTCTCAGATTATTGTTTCAGTTATATAGAGGATTACTAGA
CTAGTTATGAAGAAACCCCACTACATTCAATGGAATTGGTGCTTAAAATCTCATCGATGTGCTGTCTCTGGAGTGATAAGAAAGGGCTAC
ATCTCCCGAAATGATTTCTTTACGTCATGTATTGGTTTCCTTCTTCACCTTGAACTTTTGTTGAACTGTATGTACTTTACCCCAAACCTG
TTAATATTTTGAGCGCTTCTATGTGAAAGCAAAGAAATAATTTTAATACTCTGGCATTCATAAATTTTATTGATGAGATTATTTATTTTA
AAGGTTTGAGGTAACATCTCTGGTTGTACCAAAGAAGAAATAAATATGGTTTCTTAATCTCTTGCATGTTTTCTTATAAATAATCATGTT
CAATGAAAAGAAGTTACTGAGCTTATTTAGATACATTAAACATTACTTAACTACTGGTTCTATAGGTGTATGTTTATAATATTAGTGTTT
TTTCTACATAAAGTAATTTAAAAAGCTGTTCCACAGAGGGTGTTACCCTGTGACAGATGCGTATGTGTGTGTGTGTGTGTGTGTGTGTGT
TTTAGTGTGTATGGAGAGAGCTTCATGGACCTTTTCGAAATGTTAATTCCCTAGAAAGATGTGCAGCTGCATGCGCATCTATATTTTTGT
ATAGTATTTCAGAGATTTCGTGGACTTTTTTAAGTCTAGCCTTGCTTTATTTCTAGGTTAAGAACCACTGCCTTCATTCCAATGGCTTGT
TAGCTCCCTCCTACTCAGAACTTTATTGTAAACATGATTTATGTTTCACCATTTCTTGTAAATTTTATAAATGCAGCTCAGCTAAAGCAC
TGTATTCTTAACAAGTATTTCCTGACCACTTAAGCACTTTATTATTATCTGTGTAATCATATTGGCTTGCTGTTTCATTAACATCTACTT
AACTATCCAACAGACTTAATATATTCATTTTATATCACAGAGCCTGTGAGTAACCTGTGCTGGGGCATAAAACAATAGCTCAACATAGTA
TCTTTAGTTAGTTTATGGAACTAAATTCTGTCAAGTCAAAGGAGAGTGAGCCCTAATATAATTTTTTATATATATTTTTCTCGTGTGTAC
TTTTATACATTTTAAATTCTAGTCCTAGTTGTTTGGTTAAATCAATCATTATGTAATCTGTATTTGGATTTCTTTAAAACTGCTTACAGC
ATCTAGTTTTATGCTTCTAGCATGAATTTTGCTTAAGAAGATTCCAACTTTGCCATATAGATCAGTGCTATTTACATAGACTGAAAGAAT
GTTCTTTCCCTTTTTTCAAATATGACTTTTGAAAATAAAGGTCTCTGTTATAGCTCCCTAAAACAATCCTTAAAAAAATGGCAAACTTTT

>19146_19146_1_CPSF6-COL9A1_CPSF6_chr12_69633486_ENST00000266679_COL9A1_chr6_70926784_ENST00000357250_length(amino acids)=99AA_BP=1
MPQLWMVFLTQAPSPGVVHADSHAAVSLSRVRPFVKCSLTSLHGAGGWLTETGKPRRSRGSRHSRNSCHPWGASLTVSAISAIAGRAWVT

--------------------------------------------------------------
>19146_19146_2_CPSF6-COL9A1_CPSF6_chr12_69633486_ENST00000266679_COL9A1_chr6_70926784_ENST00000370499_length(transcript)=1132nt_BP=91nt
CGGCGGCGGCGGCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCA
GGTGACCCAGGCCCTGCCAGCTATGGCAGAAATGGCCGAGACGGTGAGCGAGGCCCCCCAGGGGTGGCAGGAATTCCTGGAGTGCCTGGA
CCCCCGGGACCTCCTGGGCTTCCCGGTTTCTGTGAGCCAGCCTCCTGCACCATGCAGGCTGGTCAGCGAGCATTTAACAAAGGGCCTGAC
CCTTGAAAGGCTTACTGCTGCATGGCTGTCTGCATGAACCACGCCTGGTGAAGGAGCCTGGGTGAGAAACACCATCCAAAGCTGGGGCAA
AGATGATTACCTTCAGCATGATTACAATGTATTACCTTCAGTATGATTACAGAAGTCCTACTTGACAATCACATATAGAAGAACGGTGCT
ATTCAGTAAGTTCTCTTTCCTTTCCCTTGGAGGGAAGACAGCAGAGTCATCAGTTAAAAAAAAAAAAAGAAAACCAAACACCTCCCTTGA
ATAAATTTATACTCCTGTTCCCAGGATCTTGAGCTTTAGTGTGCTATACCTATGTGTCTTATCGTGGGCCACTGTGCCAATAAACAAAAA
CAACTGTTTGGTTTACCTCAGTTGCAGTAGTTATTTTCATTTAGAAGTTGTTCTCAGATTATTGTTTCAGTTATATAGAGGATTACTAGA
CTAGTTATGAAGAAACCCCACTACATTCAATGGAATTGGTGCTTAAAATCTCATCGATGTGCTGTCTCTGGAGTGATAAGAAAGGGCTAC
ATCTCCCGAAATGATTTCTTTACGTCATGTATTGGTTTCCTTCTTCACCTTGAACTTTTGTTGAACTGTATGTACTTTACCCCAAACCTG
TTAATATTTTGAGCGCTTCTATGTGAAAGCAAAGAAATAATTTTAATACTCTGGCATTCATAAATTTTATTGATGAGATTATTTATTTTA
AAGGTTTGAGGTAACATCTCTGGTTGTACCAAAGAAGAAATAAATATGGTTTCTTAATCTCTTGCATGTTTTCTTATAAATAATCATGTT

>19146_19146_2_CPSF6-COL9A1_CPSF6_chr12_69633486_ENST00000266679_COL9A1_chr6_70926784_ENST00000370499_length(amino acids)=99AA_BP=1
MPQLWMVFLTQAPSPGVVHADSHAAVSLSRVRPFVKCSLTSLHGAGGWLTETGKPRRSRGSRHSRNSCHPWGASLTVSAISAIAGRAWVT

--------------------------------------------------------------
>19146_19146_3_CPSF6-COL9A1_CPSF6_chr12_69633486_ENST00000435070_COL9A1_chr6_70926784_ENST00000357250_length(transcript)=2191nt_BP=170nt
CTCGGAAGTGACGCAAGCGCCCCCCCACCGCCGCTAGATCCGCTGCTGCTGCCGCGGCGGGCAGACCTGCAGGAGGCGGCGGCGGCGGCG
GCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCAGGTGACCCAGG
CCCTGCCAGCTATGGCAGAAATGGCCGAGACGGTGAGCGAGGCCCCCCAGGGGTGGCAGGAATTCCTGGAGTGCCTGGACCCCCGGGACC
TCCTGGGCTTCCCGGTTTCTGTGAGCCAGCCTCCTGCACCATGCAGGCTGGTCAGCGAGCATTTAACAAAGGGCCTGACCCTTGAAAGGC
TTACTGCTGCATGGCTGTCTGCATGAACCACGCCTGGTGAAGGAGCCTGGGTGAGAAACACCATCCAAAGCTGGGGCAAAGATGATTACC
TTCAGCATGATTACAATGTATTACCTTCAGTATGATTACAGAAGTCCTACTTGACAATCACATATAGAAGAACGGTGCTATTCAGTAAGT
TCTCTTTCCTTTCCCTTGGAGGGAAGACAGCAGAGTCATCAGTTAAAAAAAAAAAAAGAAAACCAAACACCTCCCTTGAATAAATTTATA
CTCCTGTTCCCAGGATCTTGAGCTTTAGTGTGCTATACCTATGTGTCTTATCGTGGGCCACTGTGCCAATAAACAAAAACAACTGTTTGG
TTTACCTCAGTTGCAGTAGTTATTTTCATTTAGAAGTTGTTCTCAGATTATTGTTTCAGTTATATAGAGGATTACTAGACTAGTTATGAA
GAAACCCCACTACATTCAATGGAATTGGTGCTTAAAATCTCATCGATGTGCTGTCTCTGGAGTGATAAGAAAGGGCTACATCTCCCGAAA
TGATTTCTTTACGTCATGTATTGGTTTCCTTCTTCACCTTGAACTTTTGTTGAACTGTATGTACTTTACCCCAAACCTGTTAATATTTTG
AGCGCTTCTATGTGAAAGCAAAGAAATAATTTTAATACTCTGGCATTCATAAATTTTATTGATGAGATTATTTATTTTAAAGGTTTGAGG
TAACATCTCTGGTTGTACCAAAGAAGAAATAAATATGGTTTCTTAATCTCTTGCATGTTTTCTTATAAATAATCATGTTCAATGAAAAGA
AGTTACTGAGCTTATTTAGATACATTAAACATTACTTAACTACTGGTTCTATAGGTGTATGTTTATAATATTAGTGTTTTTTCTACATAA
AGTAATTTAAAAAGCTGTTCCACAGAGGGTGTTACCCTGTGACAGATGCGTATGTGTGTGTGTGTGTGTGTGTGTGTGTTTTAGTGTGTA
TGGAGAGAGCTTCATGGACCTTTTCGAAATGTTAATTCCCTAGAAAGATGTGCAGCTGCATGCGCATCTATATTTTTGTATAGTATTTCA
GAGATTTCGTGGACTTTTTTAAGTCTAGCCTTGCTTTATTTCTAGGTTAAGAACCACTGCCTTCATTCCAATGGCTTGTTAGCTCCCTCC
TACTCAGAACTTTATTGTAAACATGATTTATGTTTCACCATTTCTTGTAAATTTTATAAATGCAGCTCAGCTAAAGCACTGTATTCTTAA
CAAGTATTTCCTGACCACTTAAGCACTTTATTATTATCTGTGTAATCATATTGGCTTGCTGTTTCATTAACATCTACTTAACTATCCAAC
AGACTTAATATATTCATTTTATATCACAGAGCCTGTGAGTAACCTGTGCTGGGGCATAAAACAATAGCTCAACATAGTATCTTTAGTTAG
TTTATGGAACTAAATTCTGTCAAGTCAAAGGAGAGTGAGCCCTAATATAATTTTTTATATATATTTTTCTCGTGTGTACTTTTATACATT
TTAAATTCTAGTCCTAGTTGTTTGGTTAAATCAATCATTATGTAATCTGTATTTGGATTTCTTTAAAACTGCTTACAGCATCTAGTTTTA
TGCTTCTAGCATGAATTTTGCTTAAGAAGATTCCAACTTTGCCATATAGATCAGTGCTATTTACATAGACTGAAAGAATGTTCTTTCCCT
TTTTTCAAATATGACTTTTGAAAATAAAGGTCTCTGTTATAGCTCCCTAAAACAATCCTTAAAAAAATGGCAAACTTTTTCAGGAGCTGT

>19146_19146_3_CPSF6-COL9A1_CPSF6_chr12_69633486_ENST00000435070_COL9A1_chr6_70926784_ENST00000357250_length(amino acids)=99AA_BP=1
MPQLWMVFLTQAPSPGVVHADSHAAVSLSRVRPFVKCSLTSLHGAGGWLTETGKPRRSRGSRHSRNSCHPWGASLTVSAISAIAGRAWVT

--------------------------------------------------------------
>19146_19146_4_CPSF6-COL9A1_CPSF6_chr12_69633486_ENST00000435070_COL9A1_chr6_70926784_ENST00000370499_length(transcript)=1211nt_BP=170nt
CTCGGAAGTGACGCAAGCGCCCCCCCACCGCCGCTAGATCCGCTGCTGCTGCCGCGGCGGGCAGACCTGCAGGAGGCGGCGGCGGCGGCG
GCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCAGGTGACCCAGG
CCCTGCCAGCTATGGCAGAAATGGCCGAGACGGTGAGCGAGGCCCCCCAGGGGTGGCAGGAATTCCTGGAGTGCCTGGACCCCCGGGACC
TCCTGGGCTTCCCGGTTTCTGTGAGCCAGCCTCCTGCACCATGCAGGCTGGTCAGCGAGCATTTAACAAAGGGCCTGACCCTTGAAAGGC
TTACTGCTGCATGGCTGTCTGCATGAACCACGCCTGGTGAAGGAGCCTGGGTGAGAAACACCATCCAAAGCTGGGGCAAAGATGATTACC
TTCAGCATGATTACAATGTATTACCTTCAGTATGATTACAGAAGTCCTACTTGACAATCACATATAGAAGAACGGTGCTATTCAGTAAGT
TCTCTTTCCTTTCCCTTGGAGGGAAGACAGCAGAGTCATCAGTTAAAAAAAAAAAAAGAAAACCAAACACCTCCCTTGAATAAATTTATA
CTCCTGTTCCCAGGATCTTGAGCTTTAGTGTGCTATACCTATGTGTCTTATCGTGGGCCACTGTGCCAATAAACAAAAACAACTGTTTGG
TTTACCTCAGTTGCAGTAGTTATTTTCATTTAGAAGTTGTTCTCAGATTATTGTTTCAGTTATATAGAGGATTACTAGACTAGTTATGAA
GAAACCCCACTACATTCAATGGAATTGGTGCTTAAAATCTCATCGATGTGCTGTCTCTGGAGTGATAAGAAAGGGCTACATCTCCCGAAA
TGATTTCTTTACGTCATGTATTGGTTTCCTTCTTCACCTTGAACTTTTGTTGAACTGTATGTACTTTACCCCAAACCTGTTAATATTTTG
AGCGCTTCTATGTGAAAGCAAAGAAATAATTTTAATACTCTGGCATTCATAAATTTTATTGATGAGATTATTTATTTTAAAGGTTTGAGG
TAACATCTCTGGTTGTACCAAAGAAGAAATAAATATGGTTTCTTAATCTCTTGCATGTTTTCTTATAAATAATCATGTTCAATGAAAAGA

>19146_19146_4_CPSF6-COL9A1_CPSF6_chr12_69633486_ENST00000435070_COL9A1_chr6_70926784_ENST00000370499_length(amino acids)=110AA_BP=0
MLADQPAWCRRLAHRNREAQEVPGVQALQEFLPPLGGLAHRLGHFCHSWQGLGHLVELFADIRVNVYVVHAVRHLPSASAAAAAAASCRS

--------------------------------------------------------------
>19146_19146_5_CPSF6-COL9A1_CPSF6_chr12_69633486_ENST00000456847_COL9A1_chr6_70926784_ENST00000357250_length(transcript)=2128nt_BP=107nt
GACCTGCAGGAGGCGGCGGCGGCGGCGGCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCG
GCGAAGAGTTCAACCAGGTGACCCAGGCCCTGCCAGCTATGGCAGAAATGGCCGAGACGGTGAGCGAGGCCCCCCAGGGGTGGCAGGAAT
TCCTGGAGTGCCTGGACCCCCGGGACCTCCTGGGCTTCCCGGTTTCTGTGAGCCAGCCTCCTGCACCATGCAGGCTGGTCAGCGAGCATT
TAACAAAGGGCCTGACCCTTGAAAGGCTTACTGCTGCATGGCTGTCTGCATGAACCACGCCTGGTGAAGGAGCCTGGGTGAGAAACACCA
TCCAAAGCTGGGGCAAAGATGATTACCTTCAGCATGATTACAATGTATTACCTTCAGTATGATTACAGAAGTCCTACTTGACAATCACAT
ATAGAAGAACGGTGCTATTCAGTAAGTTCTCTTTCCTTTCCCTTGGAGGGAAGACAGCAGAGTCATCAGTTAAAAAAAAAAAAAGAAAAC
CAAACACCTCCCTTGAATAAATTTATACTCCTGTTCCCAGGATCTTGAGCTTTAGTGTGCTATACCTATGTGTCTTATCGTGGGCCACTG
TGCCAATAAACAAAAACAACTGTTTGGTTTACCTCAGTTGCAGTAGTTATTTTCATTTAGAAGTTGTTCTCAGATTATTGTTTCAGTTAT
ATAGAGGATTACTAGACTAGTTATGAAGAAACCCCACTACATTCAATGGAATTGGTGCTTAAAATCTCATCGATGTGCTGTCTCTGGAGT
GATAAGAAAGGGCTACATCTCCCGAAATGATTTCTTTACGTCATGTATTGGTTTCCTTCTTCACCTTGAACTTTTGTTGAACTGTATGTA
CTTTACCCCAAACCTGTTAATATTTTGAGCGCTTCTATGTGAAAGCAAAGAAATAATTTTAATACTCTGGCATTCATAAATTTTATTGAT
GAGATTATTTATTTTAAAGGTTTGAGGTAACATCTCTGGTTGTACCAAAGAAGAAATAAATATGGTTTCTTAATCTCTTGCATGTTTTCT
TATAAATAATCATGTTCAATGAAAAGAAGTTACTGAGCTTATTTAGATACATTAAACATTACTTAACTACTGGTTCTATAGGTGTATGTT
TATAATATTAGTGTTTTTTCTACATAAAGTAATTTAAAAAGCTGTTCCACAGAGGGTGTTACCCTGTGACAGATGCGTATGTGTGTGTGT
GTGTGTGTGTGTGTGTTTTAGTGTGTATGGAGAGAGCTTCATGGACCTTTTCGAAATGTTAATTCCCTAGAAAGATGTGCAGCTGCATGC
GCATCTATATTTTTGTATAGTATTTCAGAGATTTCGTGGACTTTTTTAAGTCTAGCCTTGCTTTATTTCTAGGTTAAGAACCACTGCCTT
CATTCCAATGGCTTGTTAGCTCCCTCCTACTCAGAACTTTATTGTAAACATGATTTATGTTTCACCATTTCTTGTAAATTTTATAAATGC
AGCTCAGCTAAAGCACTGTATTCTTAACAAGTATTTCCTGACCACTTAAGCACTTTATTATTATCTGTGTAATCATATTGGCTTGCTGTT
TCATTAACATCTACTTAACTATCCAACAGACTTAATATATTCATTTTATATCACAGAGCCTGTGAGTAACCTGTGCTGGGGCATAAAACA
ATAGCTCAACATAGTATCTTTAGTTAGTTTATGGAACTAAATTCTGTCAAGTCAAAGGAGAGTGAGCCCTAATATAATTTTTTATATATA
TTTTTCTCGTGTGTACTTTTATACATTTTAAATTCTAGTCCTAGTTGTTTGGTTAAATCAATCATTATGTAATCTGTATTTGGATTTCTT
TAAAACTGCTTACAGCATCTAGTTTTATGCTTCTAGCATGAATTTTGCTTAAGAAGATTCCAACTTTGCCATATAGATCAGTGCTATTTA
CATAGACTGAAAGAATGTTCTTTCCCTTTTTTCAAATATGACTTTTGAAAATAAAGGTCTCTGTTATAGCTCCCTAAAACAATCCTTAAA

>19146_19146_5_CPSF6-COL9A1_CPSF6_chr12_69633486_ENST00000456847_COL9A1_chr6_70926784_ENST00000357250_length(amino acids)=99AA_BP=1
MPQLWMVFLTQAPSPGVVHADSHAAVSLSRVRPFVKCSLTSLHGAGGWLTETGKPRRSRGSRHSRNSCHPWGASLTVSAISAIAGRAWVT

--------------------------------------------------------------
>19146_19146_6_CPSF6-COL9A1_CPSF6_chr12_69633486_ENST00000456847_COL9A1_chr6_70926784_ENST00000370499_length(transcript)=1148nt_BP=107nt
GACCTGCAGGAGGCGGCGGCGGCGGCGGCGGCCGAGGCTGAAGGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCG
GCGAAGAGTTCAACCAGGTGACCCAGGCCCTGCCAGCTATGGCAGAAATGGCCGAGACGGTGAGCGAGGCCCCCCAGGGGTGGCAGGAAT
TCCTGGAGTGCCTGGACCCCCGGGACCTCCTGGGCTTCCCGGTTTCTGTGAGCCAGCCTCCTGCACCATGCAGGCTGGTCAGCGAGCATT
TAACAAAGGGCCTGACCCTTGAAAGGCTTACTGCTGCATGGCTGTCTGCATGAACCACGCCTGGTGAAGGAGCCTGGGTGAGAAACACCA
TCCAAAGCTGGGGCAAAGATGATTACCTTCAGCATGATTACAATGTATTACCTTCAGTATGATTACAGAAGTCCTACTTGACAATCACAT
ATAGAAGAACGGTGCTATTCAGTAAGTTCTCTTTCCTTTCCCTTGGAGGGAAGACAGCAGAGTCATCAGTTAAAAAAAAAAAAAGAAAAC
CAAACACCTCCCTTGAATAAATTTATACTCCTGTTCCCAGGATCTTGAGCTTTAGTGTGCTATACCTATGTGTCTTATCGTGGGCCACTG
TGCCAATAAACAAAAACAACTGTTTGGTTTACCTCAGTTGCAGTAGTTATTTTCATTTAGAAGTTGTTCTCAGATTATTGTTTCAGTTAT
ATAGAGGATTACTAGACTAGTTATGAAGAAACCCCACTACATTCAATGGAATTGGTGCTTAAAATCTCATCGATGTGCTGTCTCTGGAGT
GATAAGAAAGGGCTACATCTCCCGAAATGATTTCTTTACGTCATGTATTGGTTTCCTTCTTCACCTTGAACTTTTGTTGAACTGTATGTA
CTTTACCCCAAACCTGTTAATATTTTGAGCGCTTCTATGTGAAAGCAAAGAAATAATTTTAATACTCTGGCATTCATAAATTTTATTGAT
GAGATTATTTATTTTAAAGGTTTGAGGTAACATCTCTGGTTGTACCAAAGAAGAAATAAATATGGTTTCTTAATCTCTTGCATGTTTTCT

>19146_19146_6_CPSF6-COL9A1_CPSF6_chr12_69633486_ENST00000456847_COL9A1_chr6_70926784_ENST00000370499_length(amino acids)=99AA_BP=1
MPQLWMVFLTQAPSPGVVHADSHAAVSLSRVRPFVKCSLTSLHGAGGWLTETGKPRRSRGSRHSRNSCHPWGASLTVSAISAIAGRAWVT

--------------------------------------------------------------
>19146_19146_7_CPSF6-COL9A1_CPSF6_chr12_69633486_ENST00000551516_COL9A1_chr6_70926784_ENST00000357250_length(transcript)=2086nt_BP=65nt
GGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCAGGTGACCCAGGCCCTGCCAGCTATGG
CAGAAATGGCCGAGACGGTGAGCGAGGCCCCCCAGGGGTGGCAGGAATTCCTGGAGTGCCTGGACCCCCGGGACCTCCTGGGCTTCCCGG
TTTCTGTGAGCCAGCCTCCTGCACCATGCAGGCTGGTCAGCGAGCATTTAACAAAGGGCCTGACCCTTGAAAGGCTTACTGCTGCATGGC
TGTCTGCATGAACCACGCCTGGTGAAGGAGCCTGGGTGAGAAACACCATCCAAAGCTGGGGCAAAGATGATTACCTTCAGCATGATTACA
ATGTATTACCTTCAGTATGATTACAGAAGTCCTACTTGACAATCACATATAGAAGAACGGTGCTATTCAGTAAGTTCTCTTTCCTTTCCC
TTGGAGGGAAGACAGCAGAGTCATCAGTTAAAAAAAAAAAAAGAAAACCAAACACCTCCCTTGAATAAATTTATACTCCTGTTCCCAGGA
TCTTGAGCTTTAGTGTGCTATACCTATGTGTCTTATCGTGGGCCACTGTGCCAATAAACAAAAACAACTGTTTGGTTTACCTCAGTTGCA
GTAGTTATTTTCATTTAGAAGTTGTTCTCAGATTATTGTTTCAGTTATATAGAGGATTACTAGACTAGTTATGAAGAAACCCCACTACAT
TCAATGGAATTGGTGCTTAAAATCTCATCGATGTGCTGTCTCTGGAGTGATAAGAAAGGGCTACATCTCCCGAAATGATTTCTTTACGTC
ATGTATTGGTTTCCTTCTTCACCTTGAACTTTTGTTGAACTGTATGTACTTTACCCCAAACCTGTTAATATTTTGAGCGCTTCTATGTGA
AAGCAAAGAAATAATTTTAATACTCTGGCATTCATAAATTTTATTGATGAGATTATTTATTTTAAAGGTTTGAGGTAACATCTCTGGTTG
TACCAAAGAAGAAATAAATATGGTTTCTTAATCTCTTGCATGTTTTCTTATAAATAATCATGTTCAATGAAAAGAAGTTACTGAGCTTAT
TTAGATACATTAAACATTACTTAACTACTGGTTCTATAGGTGTATGTTTATAATATTAGTGTTTTTTCTACATAAAGTAATTTAAAAAGC
TGTTCCACAGAGGGTGTTACCCTGTGACAGATGCGTATGTGTGTGTGTGTGTGTGTGTGTGTGTTTTAGTGTGTATGGAGAGAGCTTCAT
GGACCTTTTCGAAATGTTAATTCCCTAGAAAGATGTGCAGCTGCATGCGCATCTATATTTTTGTATAGTATTTCAGAGATTTCGTGGACT
TTTTTAAGTCTAGCCTTGCTTTATTTCTAGGTTAAGAACCACTGCCTTCATTCCAATGGCTTGTTAGCTCCCTCCTACTCAGAACTTTAT
TGTAAACATGATTTATGTTTCACCATTTCTTGTAAATTTTATAAATGCAGCTCAGCTAAAGCACTGTATTCTTAACAAGTATTTCCTGAC
CACTTAAGCACTTTATTATTATCTGTGTAATCATATTGGCTTGCTGTTTCATTAACATCTACTTAACTATCCAACAGACTTAATATATTC
ATTTTATATCACAGAGCCTGTGAGTAACCTGTGCTGGGGCATAAAACAATAGCTCAACATAGTATCTTTAGTTAGTTTATGGAACTAAAT
TCTGTCAAGTCAAAGGAGAGTGAGCCCTAATATAATTTTTTATATATATTTTTCTCGTGTGTACTTTTATACATTTTAAATTCTAGTCCT
AGTTGTTTGGTTAAATCAATCATTATGTAATCTGTATTTGGATTTCTTTAAAACTGCTTACAGCATCTAGTTTTATGCTTCTAGCATGAA
TTTTGCTTAAGAAGATTCCAACTTTGCCATATAGATCAGTGCTATTTACATAGACTGAAAGAATGTTCTTTCCCTTTTTTCAAATATGAC
TTTTGAAAATAAAGGTCTCTGTTATAGCTCCCTAAAACAATCCTTAAAAAAATGGCAAACTTTTTCAGGAGCTGTGACACATAATTAAAT

>19146_19146_7_CPSF6-COL9A1_CPSF6_chr12_69633486_ENST00000551516_COL9A1_chr6_70926784_ENST00000357250_length(amino acids)=99AA_BP=1
MPQLWMVFLTQAPSPGVVHADSHAAVSLSRVRPFVKCSLTSLHGAGGWLTETGKPRRSRGSRHSRNSCHPWGASLTVSAISAIAGRAWVT

--------------------------------------------------------------
>19146_19146_8_CPSF6-COL9A1_CPSF6_chr12_69633486_ENST00000551516_COL9A1_chr6_70926784_ENST00000370499_length(transcript)=1106nt_BP=65nt
GGAAGATGGCGGACGGCGTGGACCACATAGACATTTACGCGGATGTCGGCGAAGAGTTCAACCAGGTGACCCAGGCCCTGCCAGCTATGG
CAGAAATGGCCGAGACGGTGAGCGAGGCCCCCCAGGGGTGGCAGGAATTCCTGGAGTGCCTGGACCCCCGGGACCTCCTGGGCTTCCCGG
TTTCTGTGAGCCAGCCTCCTGCACCATGCAGGCTGGTCAGCGAGCATTTAACAAAGGGCCTGACCCTTGAAAGGCTTACTGCTGCATGGC
TGTCTGCATGAACCACGCCTGGTGAAGGAGCCTGGGTGAGAAACACCATCCAAAGCTGGGGCAAAGATGATTACCTTCAGCATGATTACA
ATGTATTACCTTCAGTATGATTACAGAAGTCCTACTTGACAATCACATATAGAAGAACGGTGCTATTCAGTAAGTTCTCTTTCCTTTCCC
TTGGAGGGAAGACAGCAGAGTCATCAGTTAAAAAAAAAAAAAGAAAACCAAACACCTCCCTTGAATAAATTTATACTCCTGTTCCCAGGA
TCTTGAGCTTTAGTGTGCTATACCTATGTGTCTTATCGTGGGCCACTGTGCCAATAAACAAAAACAACTGTTTGGTTTACCTCAGTTGCA
GTAGTTATTTTCATTTAGAAGTTGTTCTCAGATTATTGTTTCAGTTATATAGAGGATTACTAGACTAGTTATGAAGAAACCCCACTACAT
TCAATGGAATTGGTGCTTAAAATCTCATCGATGTGCTGTCTCTGGAGTGATAAGAAAGGGCTACATCTCCCGAAATGATTTCTTTACGTC
ATGTATTGGTTTCCTTCTTCACCTTGAACTTTTGTTGAACTGTATGTACTTTACCCCAAACCTGTTAATATTTTGAGCGCTTCTATGTGA
AAGCAAAGAAATAATTTTAATACTCTGGCATTCATAAATTTTATTGATGAGATTATTTATTTTAAAGGTTTGAGGTAACATCTCTGGTTG
TACCAAAGAAGAAATAAATATGGTTTCTTAATCTCTTGCATGTTTTCTTATAAATAATCATGTTCAATGAAAAGAAGTTACTGAGCTTAT

>19146_19146_8_CPSF6-COL9A1_CPSF6_chr12_69633486_ENST00000551516_COL9A1_chr6_70926784_ENST00000370499_length(amino acids)=99AA_BP=1
MPQLWMVFLTQAPSPGVVHADSHAAVSLSRVRPFVKCSLTSLHGAGGWLTETGKPRRSRGSRHSRNSCHPWGASLTVSAISAIAGRAWVT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CPSF6-COL9A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CPSF6-COL9A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CPSF6-COL9A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0265253Stickler syndrome (disorder)4CLINGEN
TgeneC0026760Multiple Epiphyseal Dysplasia3CTD_human;GENOMICS_ENGLAND
TgeneC0013366Dyschondroplasias2CTD_human
TgeneC0025237Melnick-Needles Syndrome2CTD_human
TgeneC0029422Osteochondrodysplasias2CTD_human
TgeneC0036391Schwartz-Jampel Syndrome2CTD_human
TgeneC0038015Spondyloepiphyseal Dysplasia2CTD_human
TgeneC0432272Van Buchem disease2CTD_human
TgeneC2675767EPIPHYSEAL DYSPLASIA, MULTIPLE, 62CTD_human;GENOMICS_ENGLAND
TgeneC3279941STICKLER SYNDROME, TYPE IV2CTD_human;GENOMICS_ENGLAND
TgeneC3541456Spondyloepiphyseal Dysplasia Tarda, X-Linked2CTD_human
TgeneC4551479Schwartz-Jampel Syndrome, Type 12CTD_human
TgeneC0008925Cleft Palate1GENOMICS_ENGLAND
TgeneC0018784Sensorineural Hearing Loss (disorder)1CTD_human
TgeneC0027092Myopia1CTD_human
TgeneC0035309Retinal Diseases1CTD_human
TgeneC1691779Sensory hearing loss1CTD_human