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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CPSF6-PTPRB (FusionGDB2 ID:HG11052TG5787)

Fusion Gene Summary for CPSF6-PTPRB

check button Fusion gene summary
Fusion gene informationFusion gene name: CPSF6-PTPRB
Fusion gene ID: hg11052tg5787
HgeneTgene
Gene symbol

CPSF6

PTPRB

Gene ID

11052

5787

Gene namecleavage and polyadenylation specific factor 6protein tyrosine phosphatase receptor type B
SynonymsCFIM|CFIM68|CFIM72|HPBRII-4|HPBRII-7HPTP-BETA|HPTPB|PTPB|R-PTP-BETA|VEPTP
Cytomap('CPSF6')('PTPRB')

12q15

12q15

Type of geneprotein-codingprotein-coding
Descriptioncleavage and polyadenylation specificity factor subunit 6CPSF 68 kDa subunitcleavage and polyadenylation specific factor 6, 68kDacleavage and polyadenylation specificity factor 68 kDa subunitcleavage factor Im complex 68 kDa subunitpre-mRNA cleavage receptor-type tyrosine-protein phosphatase betaVE-PTPprotein tyrosine phosphatase, receptor type, beta polypeptidevascular endothelial protein tyrosine phosphatase
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000550987, ENST00000266679, 
ENST00000435070, ENST00000456847, 
ENST00000551516, 
Fusion gene scores* DoF score69 X 12 X 19=157325 X 6 X 5=150
# samples 715
** MAII scorelog2(71/15732*10)=-4.46973925655087
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/150*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CPSF6 [Title/Abstract] AND PTPRB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCPSF6(69633486)-PTPRB(70975082), # samples:4
Anticipated loss of major functional domain due to fusion event.CPSF6-PTPRB seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CPSF6-PTPRB seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
CPSF6-PTPRB seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
CPSF6-PTPRB seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCPSF6

GO:0006397

mRNA processing

14690600

HgeneCPSF6

GO:0051262

protein tetramerization

20695905

HgeneCPSF6

GO:0051290

protein heterotetramerization

23187700

HgeneCPSF6

GO:1990120

messenger ribonucleoprotein complex assembly

29276085

TgenePTPRB

GO:0016311

dephosphorylation

19116766|19136612



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-CS-4941-01ACPSF6chr12

69633485

+PTPRBchr12

70975081

-
ChimerDB4LGGTCGA-CS-4941-01ACPSF6chr12

69633486

-PTPRBchr12

70975082

-
ChimerDB4LGGTCGA-CS-4941-01ACPSF6chr12

69633486

+PTPRBchr12

70975082

-
ChimerDB4LGGTCGA-CS-4941CPSF6chr12

69633486

+PTPRBchr12

70975082

-


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Fusion Gene ORF analysis for CPSF6-PTPRB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000550987ENST00000261266CPSF6chr12

69633485

+PTPRBchr12

70975081

-
3UTR-3CDSENST00000550987ENST00000261266CPSF6chr12

69633486

+PTPRBchr12

70975082

-
3UTR-3CDSENST00000550987ENST00000334414CPSF6chr12

69633485

+PTPRBchr12

70975081

-
3UTR-3CDSENST00000550987ENST00000334414CPSF6chr12

69633486

+PTPRBchr12

70975082

-
3UTR-3CDSENST00000550987ENST00000451516CPSF6chr12

69633485

+PTPRBchr12

70975081

-
3UTR-3CDSENST00000550987ENST00000451516CPSF6chr12

69633486

+PTPRBchr12

70975082

-
3UTR-3CDSENST00000550987ENST00000538708CPSF6chr12

69633485

+PTPRBchr12

70975081

-
3UTR-3CDSENST00000550987ENST00000538708CPSF6chr12

69633486

+PTPRBchr12

70975082

-
3UTR-3CDSENST00000550987ENST00000550358CPSF6chr12

69633485

+PTPRBchr12

70975081

-
3UTR-3CDSENST00000550987ENST00000550358CPSF6chr12

69633486

+PTPRBchr12

70975082

-
3UTR-3CDSENST00000550987ENST00000550857CPSF6chr12

69633485

+PTPRBchr12

70975081

-
3UTR-3CDSENST00000550987ENST00000550857CPSF6chr12

69633486

+PTPRBchr12

70975082

-
3UTR-3CDSENST00000550987ENST00000551525CPSF6chr12

69633485

+PTPRBchr12

70975081

-
3UTR-3CDSENST00000550987ENST00000551525CPSF6chr12

69633486

+PTPRBchr12

70975082

-
3UTR-intronENST00000550987ENST00000538174CPSF6chr12

69633485

+PTPRBchr12

70975081

-
3UTR-intronENST00000550987ENST00000538174CPSF6chr12

69633486

+PTPRBchr12

70975082

-
5CDS-intronENST00000266679ENST00000538174CPSF6chr12

69633485

+PTPRBchr12

70975081

-
5CDS-intronENST00000266679ENST00000538174CPSF6chr12

69633486

+PTPRBchr12

70975082

-
5CDS-intronENST00000435070ENST00000538174CPSF6chr12

69633485

+PTPRBchr12

70975081

-
5CDS-intronENST00000435070ENST00000538174CPSF6chr12

69633486

+PTPRBchr12

70975082

-
5CDS-intronENST00000456847ENST00000538174CPSF6chr12

69633485

+PTPRBchr12

70975081

-
5CDS-intronENST00000456847ENST00000538174CPSF6chr12

69633486

+PTPRBchr12

70975082

-
5CDS-intronENST00000551516ENST00000538174CPSF6chr12

69633485

+PTPRBchr12

70975081

-
5CDS-intronENST00000551516ENST00000538174CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000266679ENST00000261266CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000266679ENST00000261266CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000266679ENST00000334414CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000266679ENST00000334414CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000266679ENST00000451516CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000266679ENST00000451516CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000266679ENST00000538708CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000266679ENST00000538708CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000266679ENST00000550358CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000266679ENST00000550358CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000266679ENST00000550857CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000266679ENST00000550857CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000266679ENST00000551525CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000266679ENST00000551525CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000435070ENST00000261266CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000435070ENST00000261266CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000435070ENST00000334414CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000435070ENST00000334414CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000435070ENST00000451516CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000435070ENST00000451516CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000435070ENST00000538708CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000435070ENST00000538708CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000435070ENST00000550358CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000435070ENST00000550358CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000435070ENST00000550857CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000435070ENST00000550857CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000435070ENST00000551525CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000435070ENST00000551525CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000456847ENST00000261266CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000456847ENST00000261266CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000456847ENST00000334414CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000456847ENST00000334414CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000456847ENST00000451516CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000456847ENST00000451516CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000456847ENST00000538708CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000456847ENST00000538708CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000456847ENST00000550358CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000456847ENST00000550358CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000456847ENST00000550857CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000456847ENST00000550857CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000456847ENST00000551525CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000456847ENST00000551525CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000551516ENST00000261266CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000551516ENST00000261266CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000551516ENST00000334414CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000551516ENST00000334414CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000551516ENST00000451516CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000551516ENST00000451516CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000551516ENST00000538708CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000551516ENST00000538708CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000551516ENST00000550358CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000551516ENST00000550358CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000551516ENST00000550857CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000551516ENST00000550857CPSF6chr12

69633486

+PTPRBchr12

70975082

-
Frame-shiftENST00000551516ENST00000551525CPSF6chr12

69633485

+PTPRBchr12

70975081

-
Frame-shiftENST00000551516ENST00000551525CPSF6chr12

69633486

+PTPRBchr12

70975082

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CPSF6-PTPRB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for CPSF6-PTPRB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:69633486/:70975082)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CPSF6-PTPRB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CPSF6-PTPRB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CPSF6-PTPRB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CPSF6-PTPRB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0018923Hemangiosarcoma1CGI;CTD_human