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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHD1-MTOR (FusionGDB2 ID:HG1105TG2475)

Fusion Gene Summary for CHD1-MTOR

check button Fusion gene summary
Fusion gene informationFusion gene name: CHD1-MTOR
Fusion gene ID: hg1105tg2475
HgeneTgene
Gene symbol

CHD1

MTOR

Gene ID

1105

2475

Gene namechromodomain helicase DNA binding protein 1mechanistic target of rapamycin kinase
SynonymsCHD-1|PILBOSFRAP|FRAP1|FRAP2|RAFT1|RAPT1|SKS
Cytomap('CHD1')('MTOR')

5q15-q21.1

1p36.22

Type of geneprotein-codingprotein-coding
Descriptionchromodomain-helicase-DNA-binding protein 1ATP-dependent helicase CHD1serine/threonine-protein kinase mTORFK506 binding protein 12-rapamycin associated protein 2FK506-binding protein 12-rapamycin complex-associated protein 1FKBP-rapamycin associated proteinFKBP12-rapamycin complex-associated protein 1mammalian target o
Modification date2020031320200329
UniProtAcc

O14646

.
Ensembl transtripts involved in fusion geneENST00000284049, ENST00000511067, 
Fusion gene scores* DoF score14 X 15 X 8=168012 X 11 X 8=1056
# samples 1919
** MAII scorelog2(19/1680*10)=-3.14438990933518
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1056*10)=-2.47453851102751
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHD1 [Title/Abstract] AND MTOR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHD1(98199112)-MTOR(11273623), # samples:4
Anticipated loss of major functional domain due to fusion event.CHD1-MTOR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHD1-MTOR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHD1-MTOR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CHD1-MTOR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CHD1-MTOR seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
CHD1-MTOR seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CHD1-MTOR seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CHD1-MTOR seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CHD1-MTOR seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
CHD1-MTOR seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
CHD1-MTOR seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CHD1-MTOR seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMTOR

GO:0001558

regulation of cell growth

18762023

TgeneMTOR

GO:0001934

positive regulation of protein phosphorylation

20233713

TgeneMTOR

GO:0006468

protein phosphorylation

12150926|15467718|18925875

TgeneMTOR

GO:0009267

cellular response to starvation

28223137

TgeneMTOR

GO:0010507

negative regulation of autophagy

30704899

TgeneMTOR

GO:0016242

negative regulation of macroautophagy

25327288

TgeneMTOR

GO:0016310

phosphorylation

11853878|25327288

TgeneMTOR

GO:0031667

response to nutrient levels

29750193

TgeneMTOR

GO:0034198

cellular response to amino acid starvation

22424946

TgeneMTOR

GO:0038202

TORC1 signaling

28223137

TgeneMTOR

GO:0043200

response to amino acid

18497260

TgeneMTOR

GO:0045727

positive regulation of translation

18762023

TgeneMTOR

GO:0046777

protein autophosphorylation

15467718

TgeneMTOR

GO:0071230

cellular response to amino acid stimulus

22424946

TgeneMTOR

GO:0071233

cellular response to leucine

22424946

TgeneMTOR

GO:1990253

cellular response to leucine starvation

22424946


check buttonFusion gene breakpoints across CHD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MTOR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LAMLTCGA-AB-2939-03ACHD1chr5

98199112

-MTORchr1

11273623

-
ChimerDB4LAMLTCGA-AB-2939_61FFWAAXX_7CHD1chr5

98199112

-MTORchr1

11273623

-
ChimerDB4LAMLTCGA-AB-2939_61FFWAAXX_7CHD1chr5

98204199

-MTORchr1

11273623

-
ChimerDB4LAMLTCGA-AB-2939_704G6AAXX_7CHD1chr5

98199112

-MTORchr1

11273623

-
ChimerDB4LAMLTCGA-AB-2939CHD1chr5

98199111

-MTORchr1

11273623

-


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Fusion Gene ORF analysis for CHD1-MTOR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000284049ENST00000376838CHD1chr5

98199112

-MTORchr1

11273623

-
5CDS-intronENST00000284049ENST00000376838CHD1chr5

98204199

-MTORchr1

11273623

-
5CDS-intronENST00000284049ENST00000376838CHD1chr5

98199111

-MTORchr1

11273623

-
5CDS-intronENST00000284049ENST00000495435CHD1chr5

98199112

-MTORchr1

11273623

-
5CDS-intronENST00000284049ENST00000495435CHD1chr5

98204199

-MTORchr1

11273623

-
5CDS-intronENST00000284049ENST00000495435CHD1chr5

98199111

-MTORchr1

11273623

-
5CDS-intronENST00000511067ENST00000376838CHD1chr5

98199112

-MTORchr1

11273623

-
5CDS-intronENST00000511067ENST00000376838CHD1chr5

98199111

-MTORchr1

11273623

-
5CDS-intronENST00000511067ENST00000495435CHD1chr5

98199112

-MTORchr1

11273623

-
5CDS-intronENST00000511067ENST00000495435CHD1chr5

98199111

-MTORchr1

11273623

-
5UTR-3CDSENST00000511067ENST00000361445CHD1chr5

98204199

-MTORchr1

11273623

-
5UTR-intronENST00000511067ENST00000376838CHD1chr5

98204199

-MTORchr1

11273623

-
5UTR-intronENST00000511067ENST00000495435CHD1chr5

98204199

-MTORchr1

11273623

-
Frame-shiftENST00000284049ENST00000361445CHD1chr5

98199112

-MTORchr1

11273623

-
Frame-shiftENST00000284049ENST00000361445CHD1chr5

98199111

-MTORchr1

11273623

-
Frame-shiftENST00000511067ENST00000361445CHD1chr5

98199112

-MTORchr1

11273623

-
Frame-shiftENST00000511067ENST00000361445CHD1chr5

98199111

-MTORchr1

11273623

-
In-frameENST00000284049ENST00000361445CHD1chr5

98204199

-MTORchr1

11273623

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000284049CHD1chr598204199-ENST00000361445MTORchr111273623-9881439815089302926

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CHD1-MTOR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CHD1-MTOR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:98199112/chr1:11273623)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHD1

O14646

.
FUNCTION: ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHD1chr5:98204199chr1:11273623ENST00000284049-3035117_13714161711.0Compositional biasNote=Ser-rich
HgeneCHD1chr5:98204199chr1:11273623ENST00000284049-30351_7014161711.0Compositional biasNote=Ser-rich
HgeneCHD1chr5:98204199chr1:11273623ENST00000284049-3035272_36414161711.0DomainChromo 1
HgeneCHD1chr5:98204199chr1:11273623ENST00000284049-3035389_45214161711.0DomainChromo 2
HgeneCHD1chr5:98204199chr1:11273623ENST00000284049-3035493_66314161711.0DomainHelicase ATP-binding
HgeneCHD1chr5:98204199chr1:11273623ENST00000284049-3035792_94314161711.0DomainHelicase C-terminal
HgeneCHD1chr5:98204199chr1:11273623ENST00000284049-3035614_61714161711.0MotifNote=DEAH box
HgeneCHD1chr5:98204199chr1:11273623ENST00000284049-3035506_51314161711.0Nucleotide bindingATP
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581382_198210392550.0DomainFAT
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519582182_251610392550.0DomainPI3K/PI4K
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519582517_254910392550.0DomainFATC
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581069_110510392550.0RepeatNote=HEAT 26
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581106_114410392550.0RepeatNote=HEAT 27
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581145_118810392550.0RepeatNote=HEAT 28
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581189_122510392550.0RepeatNote=HEAT 29
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581226_127310392550.0RepeatNote=HEAT 30
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581274_131110392550.0RepeatNote=HEAT 31
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581312_134510392550.0RepeatNote=HEAT 32
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581346_138210392550.0RepeatNote=TPR 1
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581383_140810392550.0RepeatNote=TPR 2
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581409_144210392550.0RepeatNote=TPR 3
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581443_147310392550.0RepeatNote=TPR 4
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581474_150710392550.0RepeatNote=TPR 5
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581508_154110392550.0RepeatNote=TPR 6
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581542_157410392550.0RepeatNote=TPR 7
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581575_161410392550.0RepeatNote=TPR 8
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581615_164910392550.0RepeatNote=TPR 9
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581650_169310392550.0RepeatNote=TPR 10
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581694_173110392550.0RepeatNote=TPR 11
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581732_178610392550.0RepeatNote=TPR 12
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581787_184610392550.0RepeatNote=TPR 13
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581898_193010392550.0RepeatNote=TPR 14
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581931_197010392550.0RepeatNote=TPR 15
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581971_200510392550.0RepeatNote=TPR 16

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHD1chr5:98204199chr1:11273623ENST00000284049-30351628_164414161711.0RegionNote=3 X 5 AA repeats of H-S-D-H-R
HgeneCHD1chr5:98204199chr1:11273623ENST00000284049-30351628_163214161711.0RepeatNote=1
HgeneCHD1chr5:98204199chr1:11273623ENST00000284049-30351634_163814161711.0RepeatNote=2
HgeneCHD1chr5:98204199chr1:11273623ENST00000284049-30351640_164414161711.0RepeatNote=3
TgeneMTORchr5:98204199chr1:11273623ENST000003614451958100_13710392550.0RepeatNote=HEAT 3
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581029_106810392550.0RepeatNote=HEAT 25
TgeneMTORchr5:98204199chr1:11273623ENST000003614451958138_17910392550.0RepeatNote=HEAT 4
TgeneMTORchr5:98204199chr1:11273623ENST00000361445195816_5310392550.0RepeatNote=HEAT 1
TgeneMTORchr5:98204199chr1:11273623ENST000003614451958180_22010392550.0RepeatNote=HEAT 5
TgeneMTORchr5:98204199chr1:11273623ENST000003614451958222_27610392550.0RepeatNote=HEAT 6
TgeneMTORchr5:98204199chr1:11273623ENST000003614451958277_31310392550.0RepeatNote=HEAT 7
TgeneMTORchr5:98204199chr1:11273623ENST000003614451958314_36410392550.0RepeatNote=HEAT 8
TgeneMTORchr5:98204199chr1:11273623ENST000003614451958365_40910392550.0RepeatNote=HEAT 9
TgeneMTORchr5:98204199chr1:11273623ENST000003614451958410_44510392550.0RepeatNote=HEAT 10
TgeneMTORchr5:98204199chr1:11273623ENST000003614451958446_49410392550.0RepeatNote=HEAT 11
TgeneMTORchr5:98204199chr1:11273623ENST000003614451958495_52910392550.0RepeatNote=HEAT 12
TgeneMTORchr5:98204199chr1:11273623ENST000003614451958530_56310392550.0RepeatNote=HEAT 13
TgeneMTORchr5:98204199chr1:11273623ENST00000361445195855_9910392550.0RepeatNote=HEAT 2
TgeneMTORchr5:98204199chr1:11273623ENST000003614451958564_59610392550.0RepeatNote=HEAT 14
TgeneMTORchr5:98204199chr1:11273623ENST000003614451958597_63610392550.0RepeatNote=HEAT 15
TgeneMTORchr5:98204199chr1:11273623ENST000003614451958637_68310392550.0RepeatNote=HEAT 16
TgeneMTORchr5:98204199chr1:11273623ENST000003614451958686_72410392550.0RepeatNote=HEAT 17
TgeneMTORchr5:98204199chr1:11273623ENST000003614451958727_76610392550.0RepeatNote=HEAT 18
TgeneMTORchr5:98204199chr1:11273623ENST000003614451958769_81110392550.0RepeatNote=HEAT 19
TgeneMTORchr5:98204199chr1:11273623ENST000003614451958814_85310392550.0RepeatNote=HEAT 20
TgeneMTORchr5:98204199chr1:11273623ENST000003614451958857_89310392550.0RepeatNote=HEAT 21
TgeneMTORchr5:98204199chr1:11273623ENST000003614451958894_94210392550.0RepeatNote=HEAT 22
TgeneMTORchr5:98204199chr1:11273623ENST000003614451958943_98810392550.0RepeatNote=HEAT 23
TgeneMTORchr5:98204199chr1:11273623ENST000003614451958989_102710392550.0RepeatNote=HEAT 24


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Fusion Gene Sequence for CHD1-MTOR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16279_16279_1_CHD1-MTOR_CHD1_chr5_98204199_ENST00000284049_MTOR_chr1_11273623_ENST00000361445_length(transcript)=9881nt_BP=4398nt
AGGTGAATCAAAGGAGAGTCCCAGAAAACCTGTGACTGTTGAAGAAAATTCATCTGTGAATTTTTATATTCAAGGAGTCAGTATTTATAT
TCATCTTTTAAACTGGGAAGATTTATATTTTACTTTAAAACTTCTTGATAATAATTTACAATGAATGGACACAGTGATGAAGAAAGTGTT
AGAAACAGTAGTGGAGAATCAAGCCAGTCGGATGATGATTCTGGGTCAGCTTCAGGCTCTGGATCTGGTTCGAGTTCTGGAAGCAGTAGT
GATGGAAGCAGTAGCCAGTCAGGTAGCAGTGACTCTGACTCCGGATCTGAATCAGGCAGTCAGTCAGAGTCTGAGTCAGACACTTCCCGA
GAAAACAAAGTTCAAGCAAAACCACCGAAAGTTGATGGAGCTGAGTTTTGGAAATCTAGTCCTAGTATTCTGGCCGTTCAGAGATCTGCA
ATCCTCAAGAAGCAGCAACAGCAGCAGCAGCAACAACAACATCAAGCCTCATCTAATAGCGGATCAGAAGAGGATTCCTCTAGCAGTGAA
GATTCCGATGACTCATCAAGTGAGGTCAAAAGGAAAAAGCATAAAGATGAAGATTGGCAAATGTCTGGGTCAGGATCTCCATCTCAGTCT
GGTTCAGATTCAGAATCTGAAGAAGAGAGAGAGAAAAGCAGTTGTGATGAAACAGAATCTGATTATGAGCCAAAAAACAAAGTCAAAAGC
AGAAAACCTCAAAATAGATCTAAGTCAAAAAATGGAAAGAAGATTCTTGGACAAAAAAAGAGACAGATTGATTCATCTGAGGAGGATGAT
GATGAAGAAGATTATGATAATGATAAAAGAAGTTCTCGTCGCCAAGCAACTGTTAATGTTAGCTATAAGGAGGATGAAGAAATGAAAACA
GATTCTGATGACCTACTGGAAGTCTGTGGAGAGGATGTTCCTCAACCTGAGGAAGAGGAATTTGAAACCATAGAAAGATTTATGGATTGT
CGGATTGGGAGAAAAGGAGCTACTGGTGCTACTACAACCATCTATGCAGTTGAAGCAGATGGTGACCCAAATGCAGGCTTTGAAAAAAAC
AAAGAACCAGGAGAGATTCAGTATTTAATTAAATGGAAAGGATGGTCCCATATCCACAACACTTGGGAGACAGAAGAAACCCTCAAGCAG
CAGAATGTTAGAGGAATGAAAAAATTGGATAATTATAAGAAAAAAGATCAGGAAACAAAAAGATGGTTGAAAAATGCCTCTCCAGAAGAT
GTGGAATATTATAATTGCCAGCAAGAACTTACAGATGATCTACATAAACAGTATCAAATAGTGGAACGTATAATTGCTCATTCCAATCAA
AAGTCAGCAGCTGGTTATCCTGATTATTACTGCAAATGGCAGGGCCTTCCATACTCAGAGTGCAGCTGGGAAGATGGAGCTCTCATTTCC
AAAAAGTTTCAAGCATGCATTGATGAGTATTTTAGCAGGAACCAATCAAAAACCACTCCTTTTAAAGATTGCAAAGTATTAAAACAAAGG
CCAAGGTTTGTAGCCCTGAAGAAGCAGCCATCCTATATTGGAGGACATGAGGGCTTAGAATTAAGAGATTATCAACTGAATGGTTTAAAT
TGGCTTGCTCATTCTTGGTGCAAAGGAAATAGTTGCATACTCGCTGATGAAATGGGCCTTGGAAAAACAATACAGACGATCTCATTTCTG
AATTATTTGTTTCATGAACATCAATTATATGGACCTTTTTTATTGGTAGTACCGCTCTCCACTCTTACTTCCTGGCAAAGGGAAATTCAG
ACTTGGGCTTCTCAAATGAATGCTGTGGTTTATTTAGGTGACATTAACAGCAGAAACATGATAAGAACTCATGAATGGACGCATCATCAG
ACCAAACGGTTAAAATTTAATATATTGTTAACAACTTATGAAATTTTATTAAAAGATAAGGCATTCCTTGGAGGTCTAAATTGGGCATTT
ATAGGTGTTGATGAAGCACACCGATTAAAGAATGATGACTCCCTTCTGTATAAAACTTTAATAGATTTTAAATCCAATCATCGTCTCCTT
ATCACTGGAACTCCTCTACAGAATTCCCTCAAAGAGCTCTGGTCTTTGCTACATTTCATTATGCCAGAAAAGTTTTCTTCCTGGGAAGAT
TTTGAAGAAGAACATGGCAAAGGGAGAGAATATGGTTATGCAAGCCTTCACAAGGAGCTTGAGCCATTTCTGTTACGCCGAGTTAAGAAA
GATGTGGAAAAATCTCTTCCTGCCAAGGTTGAGCAGATTTTAAGAATGGAAATGAGTGCTTTACAGAAACAATATTACAAATGGATTTTA
ACTAGGAATTACAAAGCCCTCAGCAAAGGTTCCAAGGGCAGTACCTCAGGCTTTTTGAACATTATGATGGAGCTAAAGAAATGTTGTAAC
CATTGCTACCTCATTAAACCACCAGATAATAATGAATTCTATAATAAACAGGAGGCCTTACAACACTTAATTCGTAGTAGCGGAAAATTG
ATTCTTCTTGACAAGCTATTAATTCGCCTAAGAGAACGAGGCAATCGAGTTCTTATTTTTTCACAAATGGTGCGGATGTTAGATATACTT
GCAGAATATTTGAAATATCGTCAATTCCCCTTTCAAAGATTAGATGGATCAATAAAAGGAGAACTGAGGAAACAAGCTCTAGATCATTTT
AATGCTGAGGGATCAGAGGATTTTTGCTTTTTGCTGTCCACAAGAGCTGGAGGTCTAGGGATTAATTTAGCCTCTGCTGACACTGTTGTT
ATATTTGATTCCGATTGGAATCCACAGAATGATCTTCAGGCACAGGCTAGAGCCCATCGAATTGGGCAAAAGAAACAGGTGAATATTTAT
CGTCTAGTTACAAAGGGATCAGTTGAAGAAGATATTCTTGAAAGGGCGAAAAAGAAGATGGTTTTAGATCATCTTGTAATTCAAAGAATG
GACACAACTGGGAAGACAGTACTACATACAGGTTCTGCCCCATCAAGTTCTACTCCTTTCAATAAAGAAGAGTTATCAGCCATTTTAAAG
TTTGGTGCTGAAGAACTTTTTAAGGAACCTGAAGGAGAAGAACAAGAGCCCCAGGAAATGGATATAGATGAAATCTTGAAGAGAGCTGAA
ACTCATGAAAATGAACCAGGTCCTTTAACTGTAGGAGATGAATTGCTTTCCCAGTTCAAGGTTGCCAACTTCTCAAATATGGATGAGGAT
GACATTGAGTTGGAACCTGAAAGAAATTCAAAGAATTGGGAGGAAATTATTCCAGAAGATCAAAGAAGACGATTAGAAGAAGAAGAAAGA
CAAAAGGAACTTGAAGAAATTTATATGCTCCCAAGAATGAGAAATTGTGCAAAACAGATTAGTTTCAATGGAAGTGAAGGGAGGCGCAGT
AGAAGTAGGAGATACTCTGGATCTGATAGTGATTCCATCTCAGAAGGGAAAAGGCCAAAGAAACGTGGAAGACCACGGACTATTCCTCGG
GAGAATATTAAAGGATTTAGTGATGCAGAAATTAGGCGGTTTATCAAGAGCTATAAGAAATTTGGTGGTCCTCTGGAAAGATTAGATGCA
ATTGCTCGAGATGCTGAGTTAGTTGATAAGTCAGAAACAGACCTTAGACGACTGGGAGAATTGGTACATAATGGTTGCATTAAAGCATTA
AAGGATAGTTCTTCAGGAACAGAACGAACAGGTGGTAGACTCGGAAAAGTGAAGGGTCCAACATTCCGAATATCAGGAGTACAGGTGAAT
GCCAAACTAGTCATCTCCCATGAAGAAGAATTAATACCTTTGCACAAATCCATTCCTTCTGATCCAGAAGAAAGAAAGCAGTATACTATC
CCATGCCACACAAAGGCAGCTCATTTTGATATAGACTGGGGCAAAGAAGATGATTCCAATTTGTTAATTGGCATCTATGAATATGGATAT
GGAAGCTGGGAAATGATTAAAATGGATCCTGACCTCAGTCTAACACACAAGATTCTTCCAGATGATCCCGATAAAAAACCACAAGCAAAA
CAGTTGCAGACCCGTGCAGACTACCTCATCAAATTACTTAGTAGAGATCTTGCAAAAAAAGAAGCTCTTTCTGGTGCGGGAAGTTCAAAG
AGGAGAAAAGCAAGAGCTAAGAAGAATAAAGCAATGAAGTCTATAAAAGTGAAAGAGGAAATAAAGAGTGATTCTTCTCCTCTGCCTTCA
GAGAAGTCTGATGAAGATGATGATAAATTGAGTGAATCCAAGTCTGATGGTAGGGAAAGATCCAAGAAATCTTCAGTGTCAGATGCTCCA
GTTCATATCACGGCAAGTGGTGAACCAGTTCCCATTTCTGAAGAATCTGAAGAGCTGGATCAGAAGACATTCAGCATTGAATTCTGGGTC
ATGAACACCTCAATTCAGAGCACGATCATTCTTCTCATTGAGCAAATTGTGGTAGCTCTTGGGGGTGAATTTAAGCTCTACCTGCCCCAG
CTGATCCCACACATGCTGCGTGTCTTCATGCATGACAACAGCCCAGGCCGCATTGTCTCTATCAAGTTACTGGCTGCAATCCAGCTGTTT
GGCGCCAACCTGGATGACTACCTGCATTTACTGCTGCCTCCTATTGTTAAGTTGTTTGATGCCCCTGAAGCTCCACTGCCATCTCGAAAG
GCAGCGCTAGAGACTGTGGACCGCCTGACGGAGTCCCTGGATTTCACTGACTATGCCTCCCGGATCATTCACCCTATTGTTCGAACACTG
GACCAGAGCCCAGAACTGCGCTCCACAGCCATGGACACGCTGTCTTCACTTGTTTTTCAGCTGGGGAAGAAGTACCAAATTTTCATTCCA
ATGGTGAATAAAGTTCTGGTGCGACACCGAATCAATCATCAGCGCTATGATGTGCTCATCTGCAGAATTGTCAAGGGATACACACTTGCT
GATGAAGAGGAGGATCCTTTGATTTACCAGCATCGGATGCTTAGGAGTGGCCAAGGGGATGCATTGGCTAGTGGACCAGTGGAAACAGGA
CCCATGAAGAAACTGCACGTCAGCACCATCAACCTCCAAAAGGCCTGGGGCGCTGCCAGGAGGGTCTCCAAAGATGACTGGCTGGAATGG
CTGAGACGGCTGAGCCTGGAGCTGCTGAAGGACTCATCATCGCCCTCCCTGCGCTCCTGCTGGGCCCTGGCACAGGCCTACAACCCGATG
GCCAGGGATCTCTTCAATGCTGCATTTGTGTCCTGCTGGTCTGAACTGAATGAAGATCAACAGGATGAGCTCATCAGAAGCATCGAGTTG
GCCCTCACCTCACAAGACATCGCTGAAGTCACACAGACCCTCTTAAACTTGGCTGAATTCATGGAACACAGTGACAAGGGCCCCCTGCCA
CTGAGAGATGACAATGGCATTGTTCTGCTGGGTGAGAGAGCTGCCAAGTGCCGAGCATATGCCAAAGCACTACACTACAAAGAACTGGAG
TTCCAGAAAGGCCCCACCCCTGCCATTCTAGAATCTCTCATCAGCATTAATAATAAGCTACAGCAGCCGGAGGCAGCGGCCGGAGTGTTA
GAATATGCCATGAAACACTTTGGAGAGCTGGAGATCCAGGCTACCTGGTATGAGAAACTGCACGAGTGGGAGGATGCCCTTGTGGCCTAT
GACAAGAAAATGGACACCAACAAGGACGACCCAGAGCTGATGCTGGGCCGCATGCGCTGCCTCGAGGCCTTGGGGGAATGGGGTCAACTC
CACCAGCAGTGCTGTGAAAAGTGGACCCTGGTTAATGATGAGACCCAAGCCAAGATGGCCCGGATGGCTGCTGCAGCTGCATGGGGTTTA
GGTCAGTGGGACAGCATGGAAGAATACACCTGTATGATCCCTCGGGACACCCATGATGGGGCATTTTATAGAGCTGTGCTGGCACTGCAT
CAGGACCTCTTCTCCTTGGCACAACAGTGCATTGACAAGGCCAGGGACCTGCTGGATGCTGAATTAACTGCGATGGCAGGAGAGAGTTAC
AGTCGGGCATATGGGGCCATGGTTTCTTGCCACATGCTGTCCGAGCTGGAGGAGGTTATCCAGTACAAACTTGTCCCCGAGCGACGAGAG
ATCATCCGCCAGATCTGGTGGGAGAGACTGCAGGGCTGCCAGCGTATCGTAGAGGACTGGCAGAAAATCCTTATGGTGCGGTCCCTTGTG
GTCAGCCCTCATGAAGACATGAGAACCTGGCTCAAGTATGCAAGCCTGTGCGGCAAGAGTGGCAGGCTGGCTCTTGCTCATAAAACTTTA
GTGTTGCTCCTGGGAGTTGATCCGTCTCGGCAACTTGACCATCCTCTGCCAACAGTTCACCCTCAGGTGACCTATGCCTACATGAAAAAC
ATGTGGAAGAGTGCCCGCAAGATCGATGCCTTCCAGCACATGCAGCATTTTGTCCAGACCATGCAGCAACAGGCCCAGCATGCCATCGCT
ACTGAGGACCAGCAGCATAAGCAGGAACTGCACAAGCTCATGGCCCGATGCTTCCTGAAACTTGGAGAGTGGCAGCTGAATCTACAGGGC
ATCAATGAGAGCACAATCCCCAAAGTGCTGCAGTACTACAGCGCCGCCACAGAGCACGACCGCAGCTGGTACAAGGCCTGGCATGCGTGG
GCAGTGATGAACTTCGAAGCTGTGCTACACTACAAACATCAGAACCAAGCCCGCGATGAGAAGAAGAAACTGCGTCATGCCAGCGGGGCC
AACATCACCAACGCCACCACTGCCGCCACCACGGCCGCCACTGCCACCACCACTGCCAGCACCGAGGGCAGCAACAGTGAGAGCGAGGCC
GAGAGCACCGAGAACAGCCCCACCCCATCGCCGCTGCAGAAGAAGGTCACTGAGGATCTGTCCAAAACCCTCCTGATGTACACGGTGCCT
GCCGTCCAGGGCTTCTTCCGTTCCATCTCCTTGTCACGAGGCAACAACCTCCAGGATACACTCAGAGTTCTCACCTTATGGTTTGATTAT
GGTCACTGGCCAGATGTCAATGAGGCCTTAGTGGAGGGGGTGAAAGCCATCCAGATTGATACCTGGCTACAGGTTATACCTCAGCTCATT
GCAAGAATTGATACGCCCAGACCCTTGGTGGGACGTCTCATTCACCAGCTTCTCACAGACATTGGTCGGTACCACCCCCAGGCCCTCATC
TACCCACTGACAGTGGCTTCTAAGTCTACCACGACAGCCCGGCACAATGCAGCCAACAAGATTCTGAAGAACATGTGTGAGCACAGCAAC
ACCCTGGTCCAGCAGGCCATGATGGTGAGCGAGGAGCTGATCCGAGTGGCCATCCTCTGGCATGAGATGTGGCATGAAGGCCTGGAAGAG
GCATCTCGTTTGTACTTTGGGGAAAGGAACGTGAAAGGCATGTTTGAGGTGCTGGAGCCCTTGCATGCTATGATGGAACGGGGCCCCCAG
ACTCTGAAGGAAACATCCTTTAATCAGGCCTATGGTCGAGATTTAATGGAGGCCCAAGAGTGGTGCAGGAAGTACATGAAATCAGGGAAT
GTCAAGGACCTCACCCAAGCCTGGGACCTCTATTATCATGTGTTCCGACGAATCTCAAAGCAGCTGCCTCAGCTCACATCCTTAGAGCTG
CAATATGTTTCCCCAAAACTTCTGATGTGCCGGGACCTTGAATTGGCTGTGCCAGGAACATATGACCCCAACCAGCCAATCATTCGCATT
CAGTCCATAGCACCGTCTTTGCAAGTCATCACATCCAAGCAGAGGCCCCGGAAATTGACACTTATGGGCAGCAACGGACATGAGTTTGTT
TTCCTTCTAAAAGGCCATGAAGATCTGCGCCAGGATGAGCGTGTGATGCAGCTCTTCGGCCTGGTTAACACCCTTCTGGCCAATGACCCA
ACATCTCTTCGGAAAAACCTCAGCATCCAGAGATACGCTGTCATCCCTTTATCGACCAACTCGGGCCTCATTGGCTGGGTTCCCCACTGT
GACACACTGCACGCCCTCATCCGGGACTACAGGGAGAAGAAGAAGATCCTTCTCAACATCGAGCATCGCATCATGTTGCGGATGGCTCCG
GACTATGACCACTTGACTCTGATGCAGAAGGTGGAGGTGTTTGAGCATGCCGTCAATAATACAGCTGGGGACGACCTGGCCAAGCTGCTG
TGGCTGAAAAGCCCCAGCTCCGAGGTGTGGTTTGACCGAAGAACCAATTATACCCGTTCTTTAGCGGTCATGTCAATGGTTGGGTATATT
TTAGGCCTGGGAGATAGACACCCATCCAACCTGATGCTGGACCGTCTGAGTGGGAAGATCCTGCACATTGACTTTGGGGACTGCTTTGAG
GTTGCTATGACCCGAGAGAAGTTTCCAGAGAAGATTCCATTTAGACTAACAAGAATGTTGACCAATGCTATGGAGGTTACAGGCCTGGAT
GGCAACTACAGAATCACATGCCACACAGTGATGGAGGTGCTGCGAGAGCACAAGGACAGTGTCATGGCCGTGCTGGAAGCCTTTGTCTAT
GACCCCTTGCTGAACTGGAGGCTGATGGACACAAATACCAAAGGCAACAAGCGATCCCGAACGAGGACGGATTCCTACTCTGCTGGCCAG
TCAGTCGAAATTTTGGACGGTGTGGAACTTGGAGAGCCAGCCCATAAGAAAACGGGGACCACAGTGCCAGAATCTATTCATTCTTTCATT
GGAGACGGTTTGGTGAAACCAGAGGCCCTAAATAAGAAAGCTATCCAGATTATTAACAGGGTTCGAGATAAGCTCACTGGTCGGGACTTC
TCTCATGATGACACTTTGGATGTTCCAACGCAAGTTGAGCTGCTCATCAAACAAGCGACATCCCATGAAAACCTCTGCCAGTGCTATATT
GGCTGGTGCCCTTTCTGGTAACTGGAGGCCCAGATGTGCCCATCACGTTTTTTCTGAGGCTTTTGTACTTTAGTAAATGCTTCCACTAAA
CTGAAACCATGGTGAGAAAGTTTGACTTTGTTAAATATTTTGAAATGTAAATGAAAAGAACTACTGTATATTAAAAGTTGGTTTGAACCA
ACTTTCTAGCTGCTGTTGAAGAATATATTGTCAGAAACACAAGGCTTGATTTGGTTCCCAGGACAGTGAAACATAGTAATACCACGTAAA
TCAAGCCATTCATTTTGGGGAACAGAAGATCCATAACTTTAGAAATACGGGTTTTGACTTAACTCACAAGAGAACTCATCATAAGTACTT
GCTGATGGAAGAATGACCTAGTTGCTCCTCTCAACATGGGTACAGCAAACTCAGCACAGCCAAGAAGCCTCAGGTCGTGGAGAACATGGA
TTAGGATCCTAGACTGTAAAGACACAGAAGATGCTGACCTCACCCCTGCCACCTATCCCAAGACCTCACTGGTCTGTGGACAGCAGCAGA
AATGTTTGCAAGATAGGCCAAAATGAGTACAAAAGGTCTGTCTTCCATCAGACCCAGTGATGCTGCGACTCACACGCTTCAATTCAAGAC
CTGACCGCTAGTAGGGAGGTTTATTCAGATCGCTGGCAGCCTCGGCTGAGCAGATGCACAGAGGGGATCACTGTGCAGTGGGACCACCCT
CACTGGCCTTCTGCAGCAGGGTTCTGGGATGTTTTCAGTGGTCAAAATACTCTGTTTAGAGCAAGGGCTCAGAAAACAGAAATACTGTCA
TGGAGGTGCTGAACACAGGGAAGGTCTGGTACATATTGGAAATTATGAGCAGAACAAATACTCAACTAAATGCACAAAGTATAAAGTGTA

>16279_16279_1_CHD1-MTOR_CHD1_chr5_98204199_ENST00000284049_MTOR_chr1_11273623_ENST00000361445_length(amino acids)=2926AA_BP=1416
MNGHSDEESVRNSSGESSQSDDDSGSASGSGSGSSSGSSSDGSSSQSGSSDSDSGSESGSQSESESDTSRENKVQAKPPKVDGAEFWKSS
PSILAVQRSAILKKQQQQQQQQQHQASSNSGSEEDSSSSEDSDDSSSEVKRKKHKDEDWQMSGSGSPSQSGSDSESEEEREKSSCDETES
DYEPKNKVKSRKPQNRSKSKNGKKILGQKKRQIDSSEEDDDEEDYDNDKRSSRRQATVNVSYKEDEEMKTDSDDLLEVCGEDVPQPEEEE
FETIERFMDCRIGRKGATGATTTIYAVEADGDPNAGFEKNKEPGEIQYLIKWKGWSHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETK
RWLKNASPEDVEYYNCQQELTDDLHKQYQIVERIIAHSNQKSAAGYPDYYCKWQGLPYSECSWEDGALISKKFQACIDEYFSRNQSKTTP
FKDCKVLKQRPRFVALKKQPSYIGGHEGLELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLS
TLTSWQREIQTWASQMNAVVYLGDINSRNMIRTHEWTHHQTKRLKFNILLTTYEILLKDKAFLGGLNWAFIGVDEAHRLKNDDSLLYKTL
IDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGKGREYGYASLHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSA
LQKQYYKWILTRNYKALSKGSKGSTSGFLNIMMELKKCCNHCYLIKPPDNNEFYNKQEALQHLIRSSGKLILLDKLLIRLRERGNRVLIF
SQMVRMLDILAEYLKYRQFPFQRLDGSIKGELRKQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHR
IGQKKQVNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPFNKEELSAILKFGAEELFKEPEGEEQEPQEM
DIDEILKRAETHENEPGPLTVGDELLSQFKVANFSNMDEDDIELEPERNSKNWEEIIPEDQRRRLEEEERQKELEEIYMLPRMRNCAKQI
SFNGSEGRRSRSRRYSGSDSDSISEGKRPKKRGRPRTIPRENIKGFSDAEIRRFIKSYKKFGGPLERLDAIARDAELVDKSETDLRRLGE
LVHNGCIKALKDSSSGTERTGGRLGKVKGPTFRISGVQVNAKLVISHEEELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSN
LLIGIYEYGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAKKEALSGAGSSKRRKARAKKNKAMKSIKVKEE
IKSDSSPLPSEKSDEDDDKLSESKSDGRERSKKSSVSDAPVHITASGEPVPISEESEELDQKTFSIEFWVMNTSIQSTIILLIEQIVVAL
GGEFKLYLPQLIPHMLRVFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVDRLTESLDFTDYAS
RIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLVRHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGD
ALASGPVETGPMKKLHVSTINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQ
QDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKL
QQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMA
RMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVI
QYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVH
PQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHD
RSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSPTPSPLQKKVTEDL
SKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTD
IGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEP
LHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGT
YDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTN
SGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRS
LAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDS
VMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CHD1-MTOR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519582258_22961039.02550.0MLST8


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneMTORchr5:98204199chr1:11273623ENST0000036144519581_6511039.02550.0NBN


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHD1-MTOR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHD1-MTOR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCHD1C0009402Colorectal Carcinoma1CTD_human
HgeneCHD1C0009404Colorectal Neoplasms1CTD_human
HgeneCHD1C0025261Memory Disorders1CTD_human
HgeneCHD1C0033578Prostatic Neoplasms1CTD_human
HgeneCHD1C0233794Memory impairment1CTD_human
HgeneCHD1C0376358Malignant neoplasm of prostate1CTD_human
HgeneCHD1C0751292Age-Related Memory Disorders1CTD_human
HgeneCHD1C0751293Memory Disorder, Semantic1CTD_human
HgeneCHD1C0751294Memory Disorder, Spatial1CTD_human
HgeneCHD1C0751295Memory Loss1CTD_human
HgeneCHD1C4540131PILAROWSKI-BJORNSSON SYNDROME1GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC1846385FOCAL CORTICAL DYSPLASIA OF TAYLOR5CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC4225259SMITH-KINGSMORE SYNDROME5GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0041696Unipolar Depression2PSYGENET
TgeneC0919267ovarian neoplasm2CTD_human
TgeneC1140680Malignant neoplasm of ovary2CTD_human
TgeneC1269683Major Depressive Disorder2PSYGENET
TgeneC0001418Adenocarcinoma1CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0007102Malignant tumor of colon1CTD_human
TgeneC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneC0007134Renal Cell Carcinoma1CTD_human
TgeneC0007873Uterine Cervical Neoplasm1CTD_human
TgeneC0009375Colonic Neoplasms1CTD_human
TgeneC0014130Endocrine System Diseases1CTD_human
TgeneC0017636Glioblastoma1CTD_human
TgeneC0020538Hypertensive disease1CTD_human
TgeneC0024232Lymphatic Metastasis1CTD_human
TgeneC0025500Mesothelioma1CTD_human
TgeneC0034069Pulmonary Fibrosis1CTD_human
TgeneC0036341Schizophrenia1CTD_human
TgeneC0149504Encephalopathy, Toxic1CTD_human
TgeneC0149721Left Ventricular Hypertrophy1CTD_human
TgeneC0154659Toxic Encephalitis1CTD_human
TgeneC0205641Adenocarcinoma, Basal Cell1CTD_human
TgeneC0205642Adenocarcinoma, Oxyphilic1CTD_human
TgeneC0205643Carcinoma, Cribriform1CTD_human
TgeneC0205644Carcinoma, Granular Cell1CTD_human
TgeneC0205645Adenocarcinoma, Tubular1CTD_human
TgeneC0235032Neurotoxicity Syndromes1CTD_human
TgeneC0262584Carcinoma, Small Cell1CTD_human
TgeneC0267963Exocrine pancreatic insufficiency1CTD_human
TgeneC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CGI;CTD_human
TgeneC0334588Giant Cell Glioblastoma1CTD_human
TgeneC0334634Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse1CTD_human
TgeneC0431380Cortical Dysplasia1CTD_human
TgeneC0431391Hemimegalencephaly1GENOMICS_ENGLAND
TgeneC0543888Epileptic encephalopathy1GENOMICS_ENGLAND
TgeneC0588006Mild depression1PSYGENET
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC0751958Lymphoma, Lymphocytic, Intermediate1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneC1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC1621958Glioblastoma Multiforme1CTD_human;UNIPROT
TgeneC1955869Malformations of Cortical Development1CTD_human
TgeneC1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
TgeneC2239176Liver carcinoma1CTD_human
TgeneC3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneC4048328cervical cancer1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human
TgeneC4721507Alveolitis, Fibrosing1CTD_human