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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NUPL2-TUBGCP6 (FusionGDB2 ID:HG11097TG85378)

Fusion Gene Summary for NUPL2-TUBGCP6

check button Fusion gene summary
Fusion gene informationFusion gene name: NUPL2-TUBGCP6
Fusion gene ID: hg11097tg85378
HgeneTgene
Gene symbol

NUPL2

TUBGCP6

Gene ID

11097

85378

Gene namenucleoporin 42tubulin gamma complex associated protein 6
SynonymsCG1|NLP-1|NLP_1|NUPL2|hCG1GCP-6|GCP6|MCCRP|MCCRP1|MCPHCR
Cytomap('NUPL2')('TUBGCP6')

7p15.3

22q13.33

Type of geneprotein-codingprotein-coding
Descriptionnucleoporin NUP42H_RG271G13.9NUP42 homolognucleoporin hCG1nucleoporin like 2nucleoporin-like protein 1nucleoporin-like protein 2gamma-tubulin complex component 6
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000487595, ENST00000258742, 
ENST00000410002, 
Fusion gene scores* DoF score10 X 3 X 7=2105 X 2 X 4=40
# samples 115
** MAII scorelog2(11/210*10)=-0.932885804141463
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NUPL2 [Title/Abstract] AND TUBGCP6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNUPL2(23226765)-TUBGCP6(50658444), # samples:1
Anticipated loss of major functional domain due to fusion event.NUPL2-TUBGCP6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NUPL2-TUBGCP6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NUPL2-TUBGCP6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NUPL2-TUBGCP6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTUBGCP6

GO:0007020

microtubule nucleation

11694571


check buttonFusion gene breakpoints across NUPL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TUBGCP6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-CJ-4895-01ANUPL2chr7

23226765

+TUBGCP6chr22

50658444

-


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Fusion Gene ORF analysis for NUPL2-TUBGCP6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000487595ENST00000248846NUPL2chr7

23226765

+TUBGCP6chr22

50658444

-
3UTR-5UTRENST00000487595ENST00000439308NUPL2chr7

23226765

+TUBGCP6chr22

50658444

-
3UTR-5UTRENST00000487595ENST00000491449NUPL2chr7

23226765

+TUBGCP6chr22

50658444

-
5CDS-5UTRENST00000258742ENST00000439308NUPL2chr7

23226765

+TUBGCP6chr22

50658444

-
5CDS-5UTRENST00000258742ENST00000491449NUPL2chr7

23226765

+TUBGCP6chr22

50658444

-
5CDS-5UTRENST00000410002ENST00000439308NUPL2chr7

23226765

+TUBGCP6chr22

50658444

-
5CDS-5UTRENST00000410002ENST00000491449NUPL2chr7

23226765

+TUBGCP6chr22

50658444

-
In-frameENST00000258742ENST00000248846NUPL2chr7

23226765

+TUBGCP6chr22

50658444

-
In-frameENST00000410002ENST00000248846NUPL2chr7

23226765

+TUBGCP6chr22

50658444

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000258742NUPL2chr723226765+ENST00000248846TUBGCP6chr2250658444-21037042262055609
ENST00000410002NUPL2chr723226765+ENST00000248846TUBGCP6chr2250658444-1892493151844609

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000258742ENST00000248846NUPL2chr723226765+TUBGCP6chr2250658444-0.0172627640.98273724
ENST00000410002ENST00000248846NUPL2chr723226765+TUBGCP6chr2250658444-0.0206083730.97939163

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Fusion Genomic Features for NUPL2-TUBGCP6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for NUPL2-TUBGCP6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:23226765/chr22:50658444)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNUPL2chr7:23226765chr22:50658444ENST00000258742+3714_15148424.0RepeatNote=FG 1
HgeneNUPL2chr7:23226765chr22:50658444ENST00000258742+3795_96148424.0RepeatNote=FG 2
HgeneNUPL2chr7:23226765chr22:50658444ENST00000258742+371_25148424.0Zinc fingerC3H1-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNUPL2chr7:23226765chr22:50658444ENST00000258742+37238_378148424.0Compositional biasNote=Ser-rich
HgeneNUPL2chr7:23226765chr22:50658444ENST00000258742+37218_219148424.0RepeatNote=FG 3
HgeneNUPL2chr7:23226765chr22:50658444ENST00000258742+37220_221148424.0RepeatNote=FG 4
HgeneNUPL2chr7:23226765chr22:50658444ENST00000258742+37265_266148424.0RepeatNote=FG 5
HgeneNUPL2chr7:23226765chr22:50658444ENST00000258742+37271_272148424.0RepeatNote=FG 6
HgeneNUPL2chr7:23226765chr22:50658444ENST00000258742+37288_289148424.0RepeatNote=FG 7
HgeneNUPL2chr7:23226765chr22:50658444ENST00000258742+37290_291148424.0RepeatNote=FG 8
HgeneNUPL2chr7:23226765chr22:50658444ENST00000258742+37311_312148424.0RepeatNote=FG 9
HgeneNUPL2chr7:23226765chr22:50658444ENST00000258742+37336_337148424.0RepeatNote=FG 10
HgeneNUPL2chr7:23226765chr22:50658444ENST00000258742+37345_346148424.0RepeatNote=FG 11
HgeneNUPL2chr7:23226765chr22:50658444ENST00000258742+37364_365148424.0RepeatNote=FG 12
TgeneTUBGCP6chr7:23226765chr22:50658444ENST0000024884615251027_126913691820.0RegionNote=9 X 27 AA tandem repeats
TgeneTUBGCP6chr7:23226765chr22:50658444ENST0000024884615251027_105313691820.0RepeatNote=1
TgeneTUBGCP6chr7:23226765chr22:50658444ENST0000024884615251054_108013691820.0RepeatNote=2
TgeneTUBGCP6chr7:23226765chr22:50658444ENST0000024884615251081_110713691820.0RepeatNote=3
TgeneTUBGCP6chr7:23226765chr22:50658444ENST0000024884615251108_113413691820.0RepeatNote=4
TgeneTUBGCP6chr7:23226765chr22:50658444ENST0000024884615251135_116113691820.0RepeatNote=5
TgeneTUBGCP6chr7:23226765chr22:50658444ENST0000024884615251162_118813691820.0RepeatNote=6
TgeneTUBGCP6chr7:23226765chr22:50658444ENST0000024884615251189_121513691820.0RepeatNote=7
TgeneTUBGCP6chr7:23226765chr22:50658444ENST0000024884615251216_124213691820.0RepeatNote=8
TgeneTUBGCP6chr7:23226765chr22:50658444ENST0000024884615251243_126913691820.0RepeatNote=9


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Fusion Gene Sequence for NUPL2-TUBGCP6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>61157_61157_1_NUPL2-TUBGCP6_NUPL2_chr7_23226765_ENST00000258742_TUBGCP6_chr22_50658444_ENST00000248846_length(transcript)=2103nt_BP=704nt
ACGTAACCGTTCAAGCATCCCTCCTTCCCAGGACACACTCAAAGCGTCAGAGCGGTCCGCTCTTCTCAAGTCCTATTGGCTCAAGTCCAT
GCGTCTCATGGCACTGCCGGGTGAGAGGCGGAAAAAGGCCTTCCCAGGCGCGAGAAGATGACGTCACAGTAGCCCGGCCGGGCGCCGAGG
TTGCCTTAGGGCTCTCTGCCCAGTAACAGGCATCGAACGGTGCAGACTGAAGACGCCCTCCGTCAGCGACGCCGTCGCAATGGCCATTTG
TCAATTCTTCCTTCAAGGCCGGTGCCGCTTTGGAGATCGGTGCTGGAACGAACATCCCGGTGCTAGGGGTGCAGGAGGAGGACGGCAGCA
ACCGCAGCAGCAGCCTTCAGGTAATAATAGACGTGGATGGAATACAACTAGCCAGAGATATTCCAATGTCATCCAGCCATCCAGTTTCTC
CAAATCCACACCATGGGGGGGCAGCAGAGATCAAGAAAAGCCATATTTCAGTTCTTTTGATTCTGGAGCTTCAACTAACAGGAAGGAAGG
CTTTGGATTGTCTGAGAACCCATTTGCTTCACTTAGTCCTGATGAGCAGAAAGATGAAAAGAAACTTCTGGAAGGAATTGTAAAAGATAT
GGAGGTTTGGGAATCATCAGGGCAGTGGATGTTTTCTGTTTATTCACCAGTGAAAAAGAAACCTAATATTTCAGGCCCTGGGAGGAGCGG
GGACACTGAGGACCTCTCTCCAAATTGGCCTCTCAACTCACAGGAAGACACAGCTGCCCAGAGCAGCCCAGGCCGTGGTGAGGAGGCGGA
GGCATCGGCGGCGGAGGCTCAGGGTGGGGAGCAGGCCTACCTGGCAGGCCTGGCAGGGCAGTACCACTTGGAGCGGTACCCGGACAGTTA
CGAGTCCATGTCCGAGCCGCCCATTGCTCATCTTTTGCGCCCCGTGCTTCCCCGGGCCTTCGCCTTCCCCGTGGACCCCCAGGTCCAGTC
TGCCGCTGATGAGACTGCTGTGCAGCTGAGCGAGTTGCTGACGCTGCCCGTGCTCATGAAGCGCTCCATCACGGCACCGCTGGCCGCCCA
CATCTCCTTGGTGAACAAGGCCGCTGTCGACTACTTCTTCGTGGAGCTGCACCTGGAGGCGCACTATGAGGCACTGCGGCACTTCCTGCT
GATGGAGGACGGCGAGTTCGCCCAGTCCCTCAGCGACCTGCTCTTTGAGAAGCTTGGAGCTGGGCAAACGCCCGGAGAGCTGCTCAACCC
GCTGGTGCTGAACTCTGTGCTGAGCAAGGCCCTGCAGTGCAGCCTGCATGGGGACACCCCGCACGCCTCCAACCTCTCCCTCGCTCTCAA
GTACCTGCCCGAGGTGTTTGCCCCCAACGCCCCGGATGTGCTGAGCTGCCTGGAGCTCAGGTACAAGGTGGACTGGCCTCTCAACATTGT
CATCACCGAGGGCTGCGTGAGCAAGTACAGCGGCGTCTTCTCCTTCCTGCTGCAGCTGAAGCTCATGATGTGGGCGCTCAAGGACGTCTG
CTTCCACCTCAAGCGCACAGCCCTGCTGAGCCACATGGCCGGCTCTGTGCAGTTCCGTCAGCTGCAGCTGTTCAAGCACGAGATGCAGCA
TTTCGTGAAGGTCATCCAGGGCTACATCGCCAACCAGATCCTGCACGTCACCTGGTGCGAGTTCAGGGCCAGGTTGGCCACCGTGGGCGA
CCTGGAGGAGATCCAGCGTGCGCACGCAGAGTACCTGCACAAGGCCGTCTTCAGGGGCCTGCTCACGGAGAAGGCGGCGCCCGTCATGAA
CGTCATCCACAGCATCTTCAGCCTCGTGCTCAAGTTCCGCAGCCAGCTCATCTCCCAGGCCTGGGGGCCCCCTGGGGGCCCGCGGGGTGC
AGAGCACCCCAACTTTGCACTCATGCAGCAGTCCTACAACACCTTCAAGTACTACTCCCACTTTCTCTTCAAAGTGGTGACCAAGCTGGT
GAACCGCGGCTACCAGCCCCACCTGGAGGACTTTCTGCTGCGCATCAACTTCAACAACTACTACCAGGACGCCTGAGGCTGCTCTGCGGG

>61157_61157_1_NUPL2-TUBGCP6_NUPL2_chr7_23226765_ENST00000258742_TUBGCP6_chr22_50658444_ENST00000248846_length(amino acids)=609AA_BP=159
MKTPSVSDAVAMAICQFFLQGRCRFGDRCWNEHPGARGAGGGRQQPQQQPSGNNRRGWNTTSQRYSNVIQPSSFSKSTPWGGSRDQEKPY
FSSFDSGASTNRKEGFGLSENPFASLSPDEQKDEKKLLEGIVKDMEVWESSGQWMFSVYSPVKKKPNISGPGRSGDTEDLSPNWPLNSQE
DTAAQSSPGRGEEAEASAAEAQGGEQAYLAGLAGQYHLERYPDSYESMSEPPIAHLLRPVLPRAFAFPVDPQVQSAADETAVQLSELLTL
PVLMKRSITAPLAAHISLVNKAAVDYFFVELHLEAHYEALRHFLLMEDGEFAQSLSDLLFEKLGAGQTPGELLNPLVLNSVLSKALQCSL
HGDTPHASNLSLALKYLPEVFAPNAPDVLSCLELRYKVDWPLNIVITEGCVSKYSGVFSFLLQLKLMMWALKDVCFHLKRTALLSHMAGS
VQFRQLQLFKHEMQHFVKVIQGYIANQILHVTWCEFRARLATVGDLEEIQRAHAEYLHKAVFRGLLTEKAAPVMNVIHSIFSLVLKFRSQ

--------------------------------------------------------------
>61157_61157_2_NUPL2-TUBGCP6_NUPL2_chr7_23226765_ENST00000410002_TUBGCP6_chr22_50658444_ENST00000248846_length(transcript)=1892nt_BP=493nt
ATCGAACGGTGCAGACTGAAGACGCCCTCCGTCAGCGACGCCGTCGCAATGGCCATTTGTCAATTCTTCCTTCAAGGCCGGTGCCGCTTT
GGAGATCGGTGCTGGAACGAACATCCCGGTGCTAGGGGTGCAGGAGGAGGACGGCAGCAACCGCAGCAGCAGCCTTCAGGTAATAATAGA
CGTGGATGGAATACAACTAGCCAGAGATATTCCAATGTCATCCAGCCATCCAGTTTCTCCAAATCCACACCATGGGGGGGCAGCAGAGAT
CAAGAAAAGCCATATTTCAGTTCTTTTGATTCTGGAGCTTCAACTAACAGGAAGGAAGGCTTTGGATTGTCTGAGAACCCATTTGCTTCA
CTTAGTCCTGATGAGCAGAAAGATGAAAAGAAACTTCTGGAAGGAATTGTAAAAGATATGGAGGTTTGGGAATCATCAGGGCAGTGGATG
TTTTCTGTTTATTCACCAGTGAAAAAGAAACCTAATATTTCAGGCCCTGGGAGGAGCGGGGACACTGAGGACCTCTCTCCAAATTGGCCT
CTCAACTCACAGGAAGACACAGCTGCCCAGAGCAGCCCAGGCCGTGGTGAGGAGGCGGAGGCATCGGCGGCGGAGGCTCAGGGTGGGGAG
CAGGCCTACCTGGCAGGCCTGGCAGGGCAGTACCACTTGGAGCGGTACCCGGACAGTTACGAGTCCATGTCCGAGCCGCCCATTGCTCAT
CTTTTGCGCCCCGTGCTTCCCCGGGCCTTCGCCTTCCCCGTGGACCCCCAGGTCCAGTCTGCCGCTGATGAGACTGCTGTGCAGCTGAGC
GAGTTGCTGACGCTGCCCGTGCTCATGAAGCGCTCCATCACGGCACCGCTGGCCGCCCACATCTCCTTGGTGAACAAGGCCGCTGTCGAC
TACTTCTTCGTGGAGCTGCACCTGGAGGCGCACTATGAGGCACTGCGGCACTTCCTGCTGATGGAGGACGGCGAGTTCGCCCAGTCCCTC
AGCGACCTGCTCTTTGAGAAGCTTGGAGCTGGGCAAACGCCCGGAGAGCTGCTCAACCCGCTGGTGCTGAACTCTGTGCTGAGCAAGGCC
CTGCAGTGCAGCCTGCATGGGGACACCCCGCACGCCTCCAACCTCTCCCTCGCTCTCAAGTACCTGCCCGAGGTGTTTGCCCCCAACGCC
CCGGATGTGCTGAGCTGCCTGGAGCTCAGGTACAAGGTGGACTGGCCTCTCAACATTGTCATCACCGAGGGCTGCGTGAGCAAGTACAGC
GGCGTCTTCTCCTTCCTGCTGCAGCTGAAGCTCATGATGTGGGCGCTCAAGGACGTCTGCTTCCACCTCAAGCGCACAGCCCTGCTGAGC
CACATGGCCGGCTCTGTGCAGTTCCGTCAGCTGCAGCTGTTCAAGCACGAGATGCAGCATTTCGTGAAGGTCATCCAGGGCTACATCGCC
AACCAGATCCTGCACGTCACCTGGTGCGAGTTCAGGGCCAGGTTGGCCACCGTGGGCGACCTGGAGGAGATCCAGCGTGCGCACGCAGAG
TACCTGCACAAGGCCGTCTTCAGGGGCCTGCTCACGGAGAAGGCGGCGCCCGTCATGAACGTCATCCACAGCATCTTCAGCCTCGTGCTC
AAGTTCCGCAGCCAGCTCATCTCCCAGGCCTGGGGGCCCCCTGGGGGCCCGCGGGGTGCAGAGCACCCCAACTTTGCACTCATGCAGCAG
TCCTACAACACCTTCAAGTACTACTCCCACTTTCTCTTCAAAGTGGTGACCAAGCTGGTGAACCGCGGCTACCAGCCCCACCTGGAGGAC
TTTCTGCTGCGCATCAACTTCAACAACTACTACCAGGACGCCTGAGGCTGCTCTGCGGGGGACGTGCACAATAAAGGTGTTCTCGGACCC

>61157_61157_2_NUPL2-TUBGCP6_NUPL2_chr7_23226765_ENST00000410002_TUBGCP6_chr22_50658444_ENST00000248846_length(amino acids)=609AA_BP=159
MKTPSVSDAVAMAICQFFLQGRCRFGDRCWNEHPGARGAGGGRQQPQQQPSGNNRRGWNTTSQRYSNVIQPSSFSKSTPWGGSRDQEKPY
FSSFDSGASTNRKEGFGLSENPFASLSPDEQKDEKKLLEGIVKDMEVWESSGQWMFSVYSPVKKKPNISGPGRSGDTEDLSPNWPLNSQE
DTAAQSSPGRGEEAEASAAEAQGGEQAYLAGLAGQYHLERYPDSYESMSEPPIAHLLRPVLPRAFAFPVDPQVQSAADETAVQLSELLTL
PVLMKRSITAPLAAHISLVNKAAVDYFFVELHLEAHYEALRHFLLMEDGEFAQSLSDLLFEKLGAGQTPGELLNPLVLNSVLSKALQCSL
HGDTPHASNLSLALKYLPEVFAPNAPDVLSCLELRYKVDWPLNIVITEGCVSKYSGVFSFLLQLKLMMWALKDVCFHLKRTALLSHMAGS
VQFRQLQLFKHEMQHFVKVIQGYIANQILHVTWCEFRARLATVGDLEEIQRAHAEYLHKAVFRGLLTEKAAPVMNVIHSIFSLVLKFRSQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NUPL2-TUBGCP6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNUPL2chr7:23226765chr22:50658444ENST00000258742+37365_423148.33333333333334424.0GLE1
HgeneNUPL2chr7:23226765chr22:50658444ENST00000258742+3794_170148.33333333333334424.0HIV-1 Vpr


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NUPL2-TUBGCP6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NUPL2-TUBGCP6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0431350Primary microcephaly1GENOMICS_ENGLAND
TgeneC3278481MICROCEPHALY AND CHORIORETINOPATHY, AUTOSOMAL RECESSIVE, 11GENOMICS_ENGLAND
TgeneC3502492Microcephaly with Chorioretinopathy, Autosomal Recessive1CTD_human;ORPHANET