Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CLASRP-CALR (FusionGDB2 ID:HG11129TG811)

Fusion Gene Summary for CLASRP-CALR

check button Fusion gene summary
Fusion gene informationFusion gene name: CLASRP-CALR
Fusion gene ID: hg11129tg811
HgeneTgene
Gene symbol

CLASRP

CALR

Gene ID

11129

811

Gene nameCLK4 associating serine/arginine rich proteincalreticulin
SynonymsCLASP|SFRS16|SWAP2CRT|HEL-S-99n|RO|SSA|cC1qR
Cytomap('CLASRP')('CALR')

19q13.32

19p13.13

Type of geneprotein-codingprotein-coding
DescriptionCLK4-associating serine/arginine rich proteinClk4 associating SR-related proteinsplicing factor, arginine/serine-rich 16 (suppressor-of-white-apricot homolog, Drosophila)suppressor of white apricot homolog 2calreticulinCRP55ERp60HACBPSicca syndrome antigen A (autoantigen Ro; calreticulin)calregulinendoplasmic reticulum resident protein 60epididymis secretory sperm binding protein Li 99ngrp60
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000221455, ENST00000391953, 
ENST00000544944, 
Fusion gene scores* DoF score16 X 12 X 9=172824 X 30 X 7=5040
# samples 1738
** MAII scorelog2(17/1728*10)=-3.34549656602577
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(38/5040*10)=-3.72935241005633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLASRP [Title/Abstract] AND CALR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCLASRP(45563700)-CALR(13054559), # samples:1
Anticipated loss of major functional domain due to fusion event.CLASRP-CALR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CLASRP-CALR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CLASRP-CALR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CLASRP-CALR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCALR

GO:0000122

negative regulation of transcription by RNA polymerase II

8107809

TgeneCALR

GO:0006611

protein export from nucleus

11149926

TgeneCALR

GO:0017148

negative regulation of translation

14726956

TgeneCALR

GO:0033144

negative regulation of intracellular steroid hormone receptor signaling pathway

8107809

TgeneCALR

GO:0034504

protein localization to nucleus

15998798

TgeneCALR

GO:0045665

negative regulation of neuron differentiation

8107809

TgeneCALR

GO:0045892

negative regulation of transcription, DNA-templated

8107809

TgeneCALR

GO:0048387

negative regulation of retinoic acid receptor signaling pathway

8107809


check buttonFusion gene breakpoints across CLASRP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CALR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A154-01ACLASRPchr19

45563700

+CALRchr19

13054559

+


Top

Fusion Gene ORF analysis for CLASRP-CALR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000221455ENST00000316448CLASRPchr19

45563700

+CALRchr19

13054559

+
In-frameENST00000391953ENST00000316448CLASRPchr19

45563700

+CALRchr19

13054559

+
In-frameENST00000544944ENST00000316448CLASRPchr19

45563700

+CALRchr19

13054559

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000221455CLASRPchr1945563700+ENST00000316448CALRchr1913054559+1577833981000300
ENST00000391953CLASRPchr1945563700+ENST00000316448CALRchr1913054559+138564192808238
ENST00000544944CLASRPchr1945563700+ENST00000316448CALRchr1913054559+217114276921594300

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000221455ENST00000316448CLASRPchr1945563700+CALRchr1913054559+0.0005146310.9994854
ENST00000391953ENST00000316448CLASRPchr1945563700+CALRchr1913054559+0.0003025440.99969745
ENST00000544944ENST00000316448CLASRPchr1945563700+CALRchr1913054559+0.0003719940.99962795

Top

Fusion Genomic Features for CLASRP-CALR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for CLASRP-CALR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:45563700/chr19:13054559)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCALRchr19:45563700chr19:13054559ENST0000031644809351_4080418.0Compositional biasNote=Asp/Glu/Lys-rich
TgeneCALRchr19:45563700chr19:13054559ENST0000031644809414_4170418.0MotifNote=Prevents secretion from ER
TgeneCALRchr19:45563700chr19:13054559ENST000003164480918_1970418.0RegionNote=N-domain
TgeneCALRchr19:45563700chr19:13054559ENST0000031644809191_2550418.0RegionNote=4 X approximate repeats
TgeneCALRchr19:45563700chr19:13054559ENST0000031644809198_3080418.0RegionNote=P-domain
TgeneCALRchr19:45563700chr19:13054559ENST0000031644809259_2970418.0RegionNote=3 X approximate repeats
TgeneCALRchr19:45563700chr19:13054559ENST0000031644809309_4170418.0RegionNote=C-domain
TgeneCALRchr19:45563700chr19:13054559ENST0000031644809191_2020418.0RepeatNote=1-1
TgeneCALRchr19:45563700chr19:13054559ENST0000031644809210_2210418.0RepeatNote=1-2
TgeneCALRchr19:45563700chr19:13054559ENST0000031644809227_2380418.0RepeatNote=1-3
TgeneCALRchr19:45563700chr19:13054559ENST0000031644809244_2550418.0RepeatNote=1-4
TgeneCALRchr19:45563700chr19:13054559ENST0000031644809259_2690418.0RepeatNote=2-1
TgeneCALRchr19:45563700chr19:13054559ENST0000031644809273_2830418.0RepeatNote=2-2
TgeneCALRchr19:45563700chr19:13054559ENST0000031644809287_2970418.0RepeatNote=2-3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLASRPchr19:45563700chr19:13054559ENST00000221455+121585_6470675.0Coiled coilOntology_term=ECO:0000255
HgeneCLASRPchr19:45563700chr19:13054559ENST00000221455+121369_6730675.0Compositional biasNote=Arg-rich
HgeneCLASRPchr19:45563700chr19:13054559ENST00000221455+121377_5350675.0Compositional biasNote=Ser-rich


Top

Fusion Gene Sequence for CLASRP-CALR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16950_16950_1_CLASRP-CALR_CLASRP_chr19_45563700_ENST00000221455_CALR_chr19_13054559_ENST00000316448_length(transcript)=1577nt_BP=833nt
GCGGCCTTTCATTTCCGCTTCCGGTGCGGGCCGCGCGCGAGCGCAGCGGTGGGAGGCGGCGACCAGCCGGTTGAGGCCCCAGGCTTGGCC
TCACCACAATGTGGCACGAGGCTCGGAAGCATGAGCGGAAGCTTCGAGGCATGATGGTCGACTACAAGAAGAGGGCGGAGCGGAGACGGG
AGTATTATGAAAAGATCAAGAAGGACCCAGCCCAGTTCCTGCAGGTACATGGCCGAGCTTGCAAGGTGCACCTGGATTCTGCAGTCGCCC
TGGCCGCTGAGAGCCCTGTTAATATGATGCCCTGGCAGGGGGACACCAACAACATGATTGACCGATTCGATGTCCGTGCCCACCTGGACC
ACATCCCCGACTACACCCCCCCTCTGCTCACCACCATCTCCCCAGAACAGGAGTCGGACGAACGGAAGTGTAACTACGAGCGCTACAGAG
GCCTGGTGCAGAACGACTTTGCCGGCATCTCAGAGGAGCAGTGCCTGTACCAGATCTACATTGATGAGTTGTACGGAGGCCTCCAGAGAC
CCAGCGAAGATGAGAAGAAGAAGCTGGCAGAGAAGAAGGCTTCCATCGGTTATACCTACGAGGACAGCACGGTGGCCAAGGTAGAGAAGG
CGGCAGAAAAGCCAGAGGAGGAGGAGTCAGCGGCCGAGGAGGAGAGCAACTCGGACGAAGATGAGGTCATCCCCGACATCGACGTGGAGG
TGGACGTGGATGAATTGAACCAGGAGCAGGTGGCAGATCTCAACAAACAGGCCACGACTTATGGCATGGCCGACGGTGACTTCGTCAGTG
AGGAGGAGAAGGCCATGTACTCGGAGGAGCAGAGGCTTAAGGAGGAGGAAGAAGACAAGAAACGCAAAGAGGAGGAGGAGGCAGAGGACA
AGGAGGATGATGAGGACAAAGATGAGGATGAGGAGGATGAGGAGGACAAGGAGGAAGATGAGGAGGAAGATGTCCCCGGCCAGGCCAAGG
ACGAGCTGTAGAGAGGCCTGCCTCCAGGGCTGGACTGAGGCCTGAGCGCTCCTGCCGCAGAGCTGGCCGCGCCAAATAATGTCTCTGTGA
GACTCGAGAACTTTCATTTTTTTCCAGGCTGGTTCGGATTTGGGGTGGATTTTGGTTTTGTTCCCCTCCTCCACTCTCCCCCACCCCCTC
CCCGCCCTTTTTTTTTTTTTTTTTTAAACTGGTATTTTATCTTTGATTCTCCTTCAGCCCTCACCCCTGGTTCTCATCTTTCTTGATCAA
CATCTTTTCTTGCCTCTGTCCCCTTCTCTCATCTCTTAGCTCCCCTCCAACCTGGGGGGCAGTGGTGTGGAGAAGCCACAGGCCTGAGAT
TTCATCTGCTCTCCTTCCTGGAGCCCAGAGGAGGGCAGCAGAAGGGGGTGGTGTCTCCAACCCCCCAGCACTGAGGAAGAACGGGGCTCT
TCTCATTTCACCCCTCCCTTTCTCCCCTGCCCCCAGGACTGGGCCACTTCTGGGTGGGGCAGTGGGTCCCAGATTGGCTCACACTGAGAA

>16950_16950_1_CLASRP-CALR_CLASRP_chr19_45563700_ENST00000221455_CALR_chr19_13054559_ENST00000316448_length(amino acids)=300AA_BP=245
MWHEARKHERKLRGMMVDYKKRAERRREYYEKIKKDPAQFLQVHGRACKVHLDSAVALAAESPVNMMPWQGDTNNMIDRFDVRAHLDHIP
DYTPPLLTTISPEQESDERKCNYERYRGLVQNDFAGISEEQCLYQIYIDELYGGLQRPSEDEKKKLAEKKASIGYTYEDSTVAKVEKAAE
KPEEEESAAEEESNSDEDEVIPDIDVEVDVDELNQEQVADLNKQATTYGMADGDFVSEEEKAMYSEEQRLKEEEEDKKRKEEEEAEDKED

--------------------------------------------------------------
>16950_16950_2_CLASRP-CALR_CLASRP_chr19_45563700_ENST00000391953_CALR_chr19_13054559_ENST00000316448_length(transcript)=1385nt_BP=641nt
TTTCATTTCCGCTTCCGGTGCGGGCCGCGCGCGAGCGCAGCGGTGGGAGGCGGCGACCAGCCGGTTGAGGCCCCAGGCTTGGCCTCACCA
CAATGTGGCACGAGGCTCGGAAGCATGAGCGGAAGCTTCGAGGCATGATGGTCGACTACAAGAAGAGGGCGGAGCGGAGACGGGAGTATT
ATGAAAAGATCAAGAAGGACCCAGCCCAGTTCCTGCAGGAGTCGGACGAACGGAAGTGTAACTACGAGCGCTACAGAGGCCTGGTGCAGA
ACGACTTTGCCGGCATCTCAGAGGAGCAGTGCCTGTACCAGATCTACATTGATGAGTTGTACGGAGGCCTCCAGAGACCCAGCGAAGATG
AGAAGAAGAAGCTGGCAGAGAAGAAGGCTTCCATCGGTTATACCTACGAGGACAGCACGGTGGCCAAGGTAGAGAAGGCGGCAGAAAAGC
CAGAGGAGGAGGAGTCAGCGGCCGAGGAGGAGAGCAACTCGGACGAAGATGAGGTCATCCCCGACATCGACGTGGAGGTGGACGTGGATG
AATTGAACCAGGAGCAGGTGGCAGATCTCAACAAACAGGCCACGACTTATGGCATGGCCGACGGTGACTTCGTCAGTGAGGAGGAGAAGG
CCATGTACTCGGAGGAGCAGAGGCTTAAGGAGGAGGAAGAAGACAAGAAACGCAAAGAGGAGGAGGAGGCAGAGGACAAGGAGGATGATG
AGGACAAAGATGAGGATGAGGAGGATGAGGAGGACAAGGAGGAAGATGAGGAGGAAGATGTCCCCGGCCAGGCCAAGGACGAGCTGTAGA
GAGGCCTGCCTCCAGGGCTGGACTGAGGCCTGAGCGCTCCTGCCGCAGAGCTGGCCGCGCCAAATAATGTCTCTGTGAGACTCGAGAACT
TTCATTTTTTTCCAGGCTGGTTCGGATTTGGGGTGGATTTTGGTTTTGTTCCCCTCCTCCACTCTCCCCCACCCCCTCCCCGCCCTTTTT
TTTTTTTTTTTTTAAACTGGTATTTTATCTTTGATTCTCCTTCAGCCCTCACCCCTGGTTCTCATCTTTCTTGATCAACATCTTTTCTTG
CCTCTGTCCCCTTCTCTCATCTCTTAGCTCCCCTCCAACCTGGGGGGCAGTGGTGTGGAGAAGCCACAGGCCTGAGATTTCATCTGCTCT
CCTTCCTGGAGCCCAGAGGAGGGCAGCAGAAGGGGGTGGTGTCTCCAACCCCCCAGCACTGAGGAAGAACGGGGCTCTTCTCATTTCACC
CCTCCCTTTCTCCCCTGCCCCCAGGACTGGGCCACTTCTGGGTGGGGCAGTGGGTCCCAGATTGGCTCACACTGAGAATGTAAGAACTAC

>16950_16950_2_CLASRP-CALR_CLASRP_chr19_45563700_ENST00000391953_CALR_chr19_13054559_ENST00000316448_length(amino acids)=238AA_BP=183
MWHEARKHERKLRGMMVDYKKRAERRREYYEKIKKDPAQFLQESDERKCNYERYRGLVQNDFAGISEEQCLYQIYIDELYGGLQRPSEDE
KKKLAEKKASIGYTYEDSTVAKVEKAAEKPEEEESAAEEESNSDEDEVIPDIDVEVDVDELNQEQVADLNKQATTYGMADGDFVSEEEKA

--------------------------------------------------------------
>16950_16950_3_CLASRP-CALR_CLASRP_chr19_45563700_ENST00000544944_CALR_chr19_13054559_ENST00000316448_length(transcript)=2171nt_BP=1427nt
CTCTTTTTCTTTGGATGCTCTCCCCACCCCGCCATCTAGATCCCATCTTTAGACCTCAGCTTCACTCTGGTCTCCTTGCAACACTCCCTC
CCCGTGTTCCCACTCCCTCTAGCATCTTCATCTTCCGCCACGCCCTTCACCTGTCCTCGACCTCCACCTTCATACAACTGCACTGTTCCC
TTAAAAGCTTTCTCCGATTTCCTCCACCTGCCTTCATCCTTATTCTCCTTATCCCTCTACCACCCAGACTCATACCCAACCCCACGCATG
GCCCCTAGTGGGAGCCTTTTCAGTTCTTCTCTTTCTCTTGAGCTCCAGCCTTAAGTGCTCAGGGTTTGCCTTCTGACCCTACTTCAAACA
CTGCTGATGTTTCAAAACCTTTCATTCCCGACTCCAGCGCGTGGAATCTAGGACACCCCTTTCCCAGTGATGCTCACCTCAGAATCACCT
GAGGGTTTTTCAGAATGCCCAAGCTTCTAGATCGAAGTTGTTAGGGATGGACTTGAACATCTGGCATACTGTTCTGCAGCTTCACTTCTG
CTCCCTGAAGCTAAGAGATGTGTTGTTTGGGATCGACTCTGCCACCAACTTGTTAGATGACTTTGATTCTGCCCATACGGGTTTCACAGA
CCATCTGACTTTCCTGGTCCCTTCATCCCTCAGGTTGAGGCCCCAGGCTTGGCCTCACCACAATGTGGCACGAGGCTCGGAAGCATGAGC
GGAAGCTTCGAGGCATGATGGTCGACTACAAGAAGAGGGCGGAGCGGAGACGGGAGTATTATGAAAAGATCAAGAAGGACCCAGCCCAGT
TCCTGCAGGTACATGGCCGAGCTTGCAAGGTGCACCTGGATTCTGCAGTCGCCCTGGCCGCTGAGAGCCCTGTTAATATGATGCCCTGGC
AGGGGGACACCAACAACATGATTGACCGATTCGATGTCCGTGCCCACCTGGACCACATCCCCGACTACACCCCCCCTCTGCTCACCACCA
TCTCCCCAGAACAGGAGTCGGACGAACGGAAGTGTAACTACGAGCGCTACAGAGGCCTGGTGCAGAACGACTTTGCCGGCATCTCAGAGG
AGCAGTGCCTGTACCAGATCTACATTGATGAGTTGTACGGAGGCCTCCAGAGACCCAGCGAAGATGAGAAGAAGAAGCTGGCAGAGAAGA
AGGCTTCCATCGGTTATACCTACGAGGACAGCACGGTGGCCAAGGTAGAGAAGGCGGCAGAAAAGCCAGAGGAGGAGGAGTCAGCGGCCG
AGGAGGAGAGCAACTCGGACGAAGATGAGGTCATCCCCGACATCGACGTGGAGGTGGACGTGGATGAATTGAACCAGGAGCAGGTGGCAG
ATCTCAACAAACAGGCCACGACTTATGGCATGGCCGACGGTGACTTCGTCAGTGAGGAGGAGAAGGCCATGTACTCGGAGGAGCAGAGGC
TTAAGGAGGAGGAAGAAGACAAGAAACGCAAAGAGGAGGAGGAGGCAGAGGACAAGGAGGATGATGAGGACAAAGATGAGGATGAGGAGG
ATGAGGAGGACAAGGAGGAAGATGAGGAGGAAGATGTCCCCGGCCAGGCCAAGGACGAGCTGTAGAGAGGCCTGCCTCCAGGGCTGGACT
GAGGCCTGAGCGCTCCTGCCGCAGAGCTGGCCGCGCCAAATAATGTCTCTGTGAGACTCGAGAACTTTCATTTTTTTCCAGGCTGGTTCG
GATTTGGGGTGGATTTTGGTTTTGTTCCCCTCCTCCACTCTCCCCCACCCCCTCCCCGCCCTTTTTTTTTTTTTTTTTTAAACTGGTATT
TTATCTTTGATTCTCCTTCAGCCCTCACCCCTGGTTCTCATCTTTCTTGATCAACATCTTTTCTTGCCTCTGTCCCCTTCTCTCATCTCT
TAGCTCCCCTCCAACCTGGGGGGCAGTGGTGTGGAGAAGCCACAGGCCTGAGATTTCATCTGCTCTCCTTCCTGGAGCCCAGAGGAGGGC
AGCAGAAGGGGGTGGTGTCTCCAACCCCCCAGCACTGAGGAAGAACGGGGCTCTTCTCATTTCACCCCTCCCTTTCTCCCCTGCCCCCAG
GACTGGGCCACTTCTGGGTGGGGCAGTGGGTCCCAGATTGGCTCACACTGAGAATGTAAGAACTACAAACAAAATTTCTATTAAATTAAA

>16950_16950_3_CLASRP-CALR_CLASRP_chr19_45563700_ENST00000544944_CALR_chr19_13054559_ENST00000316448_length(amino acids)=300AA_BP=245
MWHEARKHERKLRGMMVDYKKRAERRREYYEKIKKDPAQFLQVHGRACKVHLDSAVALAAESPVNMMPWQGDTNNMIDRFDVRAHLDHIP
DYTPPLLTTISPEQESDERKCNYERYRGLVQNDFAGISEEQCLYQIYIDELYGGLQRPSEDEKKKLAEKKASIGYTYEDSTVAKVEKAAE
KPEEEESAAEEESNSDEDEVIPDIDVEVDVDELNQEQVADLNKQATTYGMADGDFVSEEEKAMYSEEQRLKEEEEDKKRKEEEEAEDKED

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CLASRP-CALR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCALRchr19:45563700chr19:13054559ENST0000031644809237_2700418.0PPIB


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CLASRP-CALR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CLASRP-CALR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0001815Primary Myelofibrosis2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0026987Myelofibrosis2GENOMICS_ENGLAND;ORPHANET
TgeneC0033975Psychotic Disorders2PSYGENET
TgeneC0036337Schizoaffective Disorder2PSYGENET
TgeneC0040028Thrombocythemia, Essential2CTD_human;ORPHANET
TgeneC0349204Nonorganic psychosis2PSYGENET
TgeneC0004565Melanoma, B161CTD_human
TgeneC0005586Bipolar Disorder1PSYGENET
TgeneC0009075Melanoma, Cloudman S911CTD_human
TgeneC0009402Colorectal Carcinoma1CTD_human
TgeneC0009404Colorectal Neoplasms1CTD_human
TgeneC0018598Melanoma, Harding-Passey1CTD_human
TgeneC0025205Melanoma, Experimental1CTD_human
TgeneC0027022Myeloproliferative disease1CTD_human
TgeneC0027626Neoplasm Invasiveness1CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0033937Psychoses, Drug1PSYGENET
TgeneC0036349Paranoid Schizophrenia1PSYGENET
TgeneC0036939Shared Paranoid Disorder1PSYGENET
TgeneC0151744Myocardial Ischemia1CTD_human
TgeneC0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human
TgeneC3277671THROMBOCYTHEMIA 11GENOMICS_ENGLAND