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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:CLASRP-CALR (FusionGDB2 ID:HG11129TG811) |
Fusion Gene Summary for CLASRP-CALR |
Fusion gene summary |
Fusion gene information | Fusion gene name: CLASRP-CALR | Fusion gene ID: hg11129tg811 | Hgene | Tgene | Gene symbol | CLASRP | CALR | Gene ID | 11129 | 811 |
Gene name | CLK4 associating serine/arginine rich protein | calreticulin | |
Synonyms | CLASP|SFRS16|SWAP2 | CRT|HEL-S-99n|RO|SSA|cC1qR | |
Cytomap | ('CLASRP')('CALR') 19q13.32 | 19p13.13 | |
Type of gene | protein-coding | protein-coding | |
Description | CLK4-associating serine/arginine rich proteinClk4 associating SR-related proteinsplicing factor, arginine/serine-rich 16 (suppressor-of-white-apricot homolog, Drosophila)suppressor of white apricot homolog 2 | calreticulinCRP55ERp60HACBPSicca syndrome antigen A (autoantigen Ro; calreticulin)calregulinendoplasmic reticulum resident protein 60epididymis secretory sperm binding protein Li 99ngrp60 | |
Modification date | 20200313 | 20200329 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000221455, ENST00000391953, ENST00000544944, | ||
Fusion gene scores | * DoF score | 16 X 12 X 9=1728 | 24 X 30 X 7=5040 |
# samples | 17 | 38 | |
** MAII score | log2(17/1728*10)=-3.34549656602577 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(38/5040*10)=-3.72935241005633 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CLASRP [Title/Abstract] AND CALR [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CLASRP(45563700)-CALR(13054559), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | CLASRP-CALR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CLASRP-CALR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CLASRP-CALR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CLASRP-CALR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CALR | GO:0000122 | negative regulation of transcription by RNA polymerase II | 8107809 |
Tgene | CALR | GO:0006611 | protein export from nucleus | 11149926 |
Tgene | CALR | GO:0017148 | negative regulation of translation | 14726956 |
Tgene | CALR | GO:0033144 | negative regulation of intracellular steroid hormone receptor signaling pathway | 8107809 |
Tgene | CALR | GO:0034504 | protein localization to nucleus | 15998798 |
Tgene | CALR | GO:0045665 | negative regulation of neuron differentiation | 8107809 |
Tgene | CALR | GO:0045892 | negative regulation of transcription, DNA-templated | 8107809 |
Tgene | CALR | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway | 8107809 |
Fusion gene breakpoints across CLASRP (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across CALR (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-E2-A154-01A | CLASRP | chr19 | 45563700 | + | CALR | chr19 | 13054559 | + |
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Fusion Gene ORF analysis for CLASRP-CALR |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000221455 | ENST00000316448 | CLASRP | chr19 | 45563700 | + | CALR | chr19 | 13054559 | + |
In-frame | ENST00000391953 | ENST00000316448 | CLASRP | chr19 | 45563700 | + | CALR | chr19 | 13054559 | + |
In-frame | ENST00000544944 | ENST00000316448 | CLASRP | chr19 | 45563700 | + | CALR | chr19 | 13054559 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000221455 | CLASRP | chr19 | 45563700 | + | ENST00000316448 | CALR | chr19 | 13054559 | + | 1577 | 833 | 98 | 1000 | 300 |
ENST00000391953 | CLASRP | chr19 | 45563700 | + | ENST00000316448 | CALR | chr19 | 13054559 | + | 1385 | 641 | 92 | 808 | 238 |
ENST00000544944 | CLASRP | chr19 | 45563700 | + | ENST00000316448 | CALR | chr19 | 13054559 | + | 2171 | 1427 | 692 | 1594 | 300 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000221455 | ENST00000316448 | CLASRP | chr19 | 45563700 | + | CALR | chr19 | 13054559 | + | 0.000514631 | 0.9994854 |
ENST00000391953 | ENST00000316448 | CLASRP | chr19 | 45563700 | + | CALR | chr19 | 13054559 | + | 0.000302544 | 0.99969745 |
ENST00000544944 | ENST00000316448 | CLASRP | chr19 | 45563700 | + | CALR | chr19 | 13054559 | + | 0.000371994 | 0.99962795 |
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Fusion Genomic Features for CLASRP-CALR |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for CLASRP-CALR |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:45563700/chr19:13054559) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | CALR | chr19:45563700 | chr19:13054559 | ENST00000316448 | 0 | 9 | 351_408 | 0 | 418.0 | Compositional bias | Note=Asp/Glu/Lys-rich | |
Tgene | CALR | chr19:45563700 | chr19:13054559 | ENST00000316448 | 0 | 9 | 414_417 | 0 | 418.0 | Motif | Note=Prevents secretion from ER | |
Tgene | CALR | chr19:45563700 | chr19:13054559 | ENST00000316448 | 0 | 9 | 18_197 | 0 | 418.0 | Region | Note=N-domain | |
Tgene | CALR | chr19:45563700 | chr19:13054559 | ENST00000316448 | 0 | 9 | 191_255 | 0 | 418.0 | Region | Note=4 X approximate repeats | |
Tgene | CALR | chr19:45563700 | chr19:13054559 | ENST00000316448 | 0 | 9 | 198_308 | 0 | 418.0 | Region | Note=P-domain | |
Tgene | CALR | chr19:45563700 | chr19:13054559 | ENST00000316448 | 0 | 9 | 259_297 | 0 | 418.0 | Region | Note=3 X approximate repeats | |
Tgene | CALR | chr19:45563700 | chr19:13054559 | ENST00000316448 | 0 | 9 | 309_417 | 0 | 418.0 | Region | Note=C-domain | |
Tgene | CALR | chr19:45563700 | chr19:13054559 | ENST00000316448 | 0 | 9 | 191_202 | 0 | 418.0 | Repeat | Note=1-1 | |
Tgene | CALR | chr19:45563700 | chr19:13054559 | ENST00000316448 | 0 | 9 | 210_221 | 0 | 418.0 | Repeat | Note=1-2 | |
Tgene | CALR | chr19:45563700 | chr19:13054559 | ENST00000316448 | 0 | 9 | 227_238 | 0 | 418.0 | Repeat | Note=1-3 | |
Tgene | CALR | chr19:45563700 | chr19:13054559 | ENST00000316448 | 0 | 9 | 244_255 | 0 | 418.0 | Repeat | Note=1-4 | |
Tgene | CALR | chr19:45563700 | chr19:13054559 | ENST00000316448 | 0 | 9 | 259_269 | 0 | 418.0 | Repeat | Note=2-1 | |
Tgene | CALR | chr19:45563700 | chr19:13054559 | ENST00000316448 | 0 | 9 | 273_283 | 0 | 418.0 | Repeat | Note=2-2 | |
Tgene | CALR | chr19:45563700 | chr19:13054559 | ENST00000316448 | 0 | 9 | 287_297 | 0 | 418.0 | Repeat | Note=2-3 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | CLASRP | chr19:45563700 | chr19:13054559 | ENST00000221455 | + | 1 | 21 | 585_647 | 0 | 675.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | CLASRP | chr19:45563700 | chr19:13054559 | ENST00000221455 | + | 1 | 21 | 369_673 | 0 | 675.0 | Compositional bias | Note=Arg-rich |
Hgene | CLASRP | chr19:45563700 | chr19:13054559 | ENST00000221455 | + | 1 | 21 | 377_535 | 0 | 675.0 | Compositional bias | Note=Ser-rich |
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Fusion Gene Sequence for CLASRP-CALR |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>16950_16950_1_CLASRP-CALR_CLASRP_chr19_45563700_ENST00000221455_CALR_chr19_13054559_ENST00000316448_length(transcript)=1577nt_BP=833nt GCGGCCTTTCATTTCCGCTTCCGGTGCGGGCCGCGCGCGAGCGCAGCGGTGGGAGGCGGCGACCAGCCGGTTGAGGCCCCAGGCTTGGCC TCACCACAATGTGGCACGAGGCTCGGAAGCATGAGCGGAAGCTTCGAGGCATGATGGTCGACTACAAGAAGAGGGCGGAGCGGAGACGGG AGTATTATGAAAAGATCAAGAAGGACCCAGCCCAGTTCCTGCAGGTACATGGCCGAGCTTGCAAGGTGCACCTGGATTCTGCAGTCGCCC TGGCCGCTGAGAGCCCTGTTAATATGATGCCCTGGCAGGGGGACACCAACAACATGATTGACCGATTCGATGTCCGTGCCCACCTGGACC ACATCCCCGACTACACCCCCCCTCTGCTCACCACCATCTCCCCAGAACAGGAGTCGGACGAACGGAAGTGTAACTACGAGCGCTACAGAG GCCTGGTGCAGAACGACTTTGCCGGCATCTCAGAGGAGCAGTGCCTGTACCAGATCTACATTGATGAGTTGTACGGAGGCCTCCAGAGAC CCAGCGAAGATGAGAAGAAGAAGCTGGCAGAGAAGAAGGCTTCCATCGGTTATACCTACGAGGACAGCACGGTGGCCAAGGTAGAGAAGG CGGCAGAAAAGCCAGAGGAGGAGGAGTCAGCGGCCGAGGAGGAGAGCAACTCGGACGAAGATGAGGTCATCCCCGACATCGACGTGGAGG TGGACGTGGATGAATTGAACCAGGAGCAGGTGGCAGATCTCAACAAACAGGCCACGACTTATGGCATGGCCGACGGTGACTTCGTCAGTG AGGAGGAGAAGGCCATGTACTCGGAGGAGCAGAGGCTTAAGGAGGAGGAAGAAGACAAGAAACGCAAAGAGGAGGAGGAGGCAGAGGACA AGGAGGATGATGAGGACAAAGATGAGGATGAGGAGGATGAGGAGGACAAGGAGGAAGATGAGGAGGAAGATGTCCCCGGCCAGGCCAAGG ACGAGCTGTAGAGAGGCCTGCCTCCAGGGCTGGACTGAGGCCTGAGCGCTCCTGCCGCAGAGCTGGCCGCGCCAAATAATGTCTCTGTGA GACTCGAGAACTTTCATTTTTTTCCAGGCTGGTTCGGATTTGGGGTGGATTTTGGTTTTGTTCCCCTCCTCCACTCTCCCCCACCCCCTC CCCGCCCTTTTTTTTTTTTTTTTTTAAACTGGTATTTTATCTTTGATTCTCCTTCAGCCCTCACCCCTGGTTCTCATCTTTCTTGATCAA CATCTTTTCTTGCCTCTGTCCCCTTCTCTCATCTCTTAGCTCCCCTCCAACCTGGGGGGCAGTGGTGTGGAGAAGCCACAGGCCTGAGAT TTCATCTGCTCTCCTTCCTGGAGCCCAGAGGAGGGCAGCAGAAGGGGGTGGTGTCTCCAACCCCCCAGCACTGAGGAAGAACGGGGCTCT TCTCATTTCACCCCTCCCTTTCTCCCCTGCCCCCAGGACTGGGCCACTTCTGGGTGGGGCAGTGGGTCCCAGATTGGCTCACACTGAGAA >16950_16950_1_CLASRP-CALR_CLASRP_chr19_45563700_ENST00000221455_CALR_chr19_13054559_ENST00000316448_length(amino acids)=300AA_BP=245 MWHEARKHERKLRGMMVDYKKRAERRREYYEKIKKDPAQFLQVHGRACKVHLDSAVALAAESPVNMMPWQGDTNNMIDRFDVRAHLDHIP DYTPPLLTTISPEQESDERKCNYERYRGLVQNDFAGISEEQCLYQIYIDELYGGLQRPSEDEKKKLAEKKASIGYTYEDSTVAKVEKAAE KPEEEESAAEEESNSDEDEVIPDIDVEVDVDELNQEQVADLNKQATTYGMADGDFVSEEEKAMYSEEQRLKEEEEDKKRKEEEEAEDKED -------------------------------------------------------------- >16950_16950_2_CLASRP-CALR_CLASRP_chr19_45563700_ENST00000391953_CALR_chr19_13054559_ENST00000316448_length(transcript)=1385nt_BP=641nt TTTCATTTCCGCTTCCGGTGCGGGCCGCGCGCGAGCGCAGCGGTGGGAGGCGGCGACCAGCCGGTTGAGGCCCCAGGCTTGGCCTCACCA CAATGTGGCACGAGGCTCGGAAGCATGAGCGGAAGCTTCGAGGCATGATGGTCGACTACAAGAAGAGGGCGGAGCGGAGACGGGAGTATT ATGAAAAGATCAAGAAGGACCCAGCCCAGTTCCTGCAGGAGTCGGACGAACGGAAGTGTAACTACGAGCGCTACAGAGGCCTGGTGCAGA ACGACTTTGCCGGCATCTCAGAGGAGCAGTGCCTGTACCAGATCTACATTGATGAGTTGTACGGAGGCCTCCAGAGACCCAGCGAAGATG AGAAGAAGAAGCTGGCAGAGAAGAAGGCTTCCATCGGTTATACCTACGAGGACAGCACGGTGGCCAAGGTAGAGAAGGCGGCAGAAAAGC CAGAGGAGGAGGAGTCAGCGGCCGAGGAGGAGAGCAACTCGGACGAAGATGAGGTCATCCCCGACATCGACGTGGAGGTGGACGTGGATG AATTGAACCAGGAGCAGGTGGCAGATCTCAACAAACAGGCCACGACTTATGGCATGGCCGACGGTGACTTCGTCAGTGAGGAGGAGAAGG CCATGTACTCGGAGGAGCAGAGGCTTAAGGAGGAGGAAGAAGACAAGAAACGCAAAGAGGAGGAGGAGGCAGAGGACAAGGAGGATGATG AGGACAAAGATGAGGATGAGGAGGATGAGGAGGACAAGGAGGAAGATGAGGAGGAAGATGTCCCCGGCCAGGCCAAGGACGAGCTGTAGA GAGGCCTGCCTCCAGGGCTGGACTGAGGCCTGAGCGCTCCTGCCGCAGAGCTGGCCGCGCCAAATAATGTCTCTGTGAGACTCGAGAACT TTCATTTTTTTCCAGGCTGGTTCGGATTTGGGGTGGATTTTGGTTTTGTTCCCCTCCTCCACTCTCCCCCACCCCCTCCCCGCCCTTTTT TTTTTTTTTTTTTAAACTGGTATTTTATCTTTGATTCTCCTTCAGCCCTCACCCCTGGTTCTCATCTTTCTTGATCAACATCTTTTCTTG CCTCTGTCCCCTTCTCTCATCTCTTAGCTCCCCTCCAACCTGGGGGGCAGTGGTGTGGAGAAGCCACAGGCCTGAGATTTCATCTGCTCT CCTTCCTGGAGCCCAGAGGAGGGCAGCAGAAGGGGGTGGTGTCTCCAACCCCCCAGCACTGAGGAAGAACGGGGCTCTTCTCATTTCACC CCTCCCTTTCTCCCCTGCCCCCAGGACTGGGCCACTTCTGGGTGGGGCAGTGGGTCCCAGATTGGCTCACACTGAGAATGTAAGAACTAC >16950_16950_2_CLASRP-CALR_CLASRP_chr19_45563700_ENST00000391953_CALR_chr19_13054559_ENST00000316448_length(amino acids)=238AA_BP=183 MWHEARKHERKLRGMMVDYKKRAERRREYYEKIKKDPAQFLQESDERKCNYERYRGLVQNDFAGISEEQCLYQIYIDELYGGLQRPSEDE KKKLAEKKASIGYTYEDSTVAKVEKAAEKPEEEESAAEEESNSDEDEVIPDIDVEVDVDELNQEQVADLNKQATTYGMADGDFVSEEEKA -------------------------------------------------------------- >16950_16950_3_CLASRP-CALR_CLASRP_chr19_45563700_ENST00000544944_CALR_chr19_13054559_ENST00000316448_length(transcript)=2171nt_BP=1427nt CTCTTTTTCTTTGGATGCTCTCCCCACCCCGCCATCTAGATCCCATCTTTAGACCTCAGCTTCACTCTGGTCTCCTTGCAACACTCCCTC CCCGTGTTCCCACTCCCTCTAGCATCTTCATCTTCCGCCACGCCCTTCACCTGTCCTCGACCTCCACCTTCATACAACTGCACTGTTCCC TTAAAAGCTTTCTCCGATTTCCTCCACCTGCCTTCATCCTTATTCTCCTTATCCCTCTACCACCCAGACTCATACCCAACCCCACGCATG GCCCCTAGTGGGAGCCTTTTCAGTTCTTCTCTTTCTCTTGAGCTCCAGCCTTAAGTGCTCAGGGTTTGCCTTCTGACCCTACTTCAAACA CTGCTGATGTTTCAAAACCTTTCATTCCCGACTCCAGCGCGTGGAATCTAGGACACCCCTTTCCCAGTGATGCTCACCTCAGAATCACCT GAGGGTTTTTCAGAATGCCCAAGCTTCTAGATCGAAGTTGTTAGGGATGGACTTGAACATCTGGCATACTGTTCTGCAGCTTCACTTCTG CTCCCTGAAGCTAAGAGATGTGTTGTTTGGGATCGACTCTGCCACCAACTTGTTAGATGACTTTGATTCTGCCCATACGGGTTTCACAGA CCATCTGACTTTCCTGGTCCCTTCATCCCTCAGGTTGAGGCCCCAGGCTTGGCCTCACCACAATGTGGCACGAGGCTCGGAAGCATGAGC GGAAGCTTCGAGGCATGATGGTCGACTACAAGAAGAGGGCGGAGCGGAGACGGGAGTATTATGAAAAGATCAAGAAGGACCCAGCCCAGT TCCTGCAGGTACATGGCCGAGCTTGCAAGGTGCACCTGGATTCTGCAGTCGCCCTGGCCGCTGAGAGCCCTGTTAATATGATGCCCTGGC AGGGGGACACCAACAACATGATTGACCGATTCGATGTCCGTGCCCACCTGGACCACATCCCCGACTACACCCCCCCTCTGCTCACCACCA TCTCCCCAGAACAGGAGTCGGACGAACGGAAGTGTAACTACGAGCGCTACAGAGGCCTGGTGCAGAACGACTTTGCCGGCATCTCAGAGG AGCAGTGCCTGTACCAGATCTACATTGATGAGTTGTACGGAGGCCTCCAGAGACCCAGCGAAGATGAGAAGAAGAAGCTGGCAGAGAAGA AGGCTTCCATCGGTTATACCTACGAGGACAGCACGGTGGCCAAGGTAGAGAAGGCGGCAGAAAAGCCAGAGGAGGAGGAGTCAGCGGCCG AGGAGGAGAGCAACTCGGACGAAGATGAGGTCATCCCCGACATCGACGTGGAGGTGGACGTGGATGAATTGAACCAGGAGCAGGTGGCAG ATCTCAACAAACAGGCCACGACTTATGGCATGGCCGACGGTGACTTCGTCAGTGAGGAGGAGAAGGCCATGTACTCGGAGGAGCAGAGGC TTAAGGAGGAGGAAGAAGACAAGAAACGCAAAGAGGAGGAGGAGGCAGAGGACAAGGAGGATGATGAGGACAAAGATGAGGATGAGGAGG ATGAGGAGGACAAGGAGGAAGATGAGGAGGAAGATGTCCCCGGCCAGGCCAAGGACGAGCTGTAGAGAGGCCTGCCTCCAGGGCTGGACT GAGGCCTGAGCGCTCCTGCCGCAGAGCTGGCCGCGCCAAATAATGTCTCTGTGAGACTCGAGAACTTTCATTTTTTTCCAGGCTGGTTCG GATTTGGGGTGGATTTTGGTTTTGTTCCCCTCCTCCACTCTCCCCCACCCCCTCCCCGCCCTTTTTTTTTTTTTTTTTTAAACTGGTATT TTATCTTTGATTCTCCTTCAGCCCTCACCCCTGGTTCTCATCTTTCTTGATCAACATCTTTTCTTGCCTCTGTCCCCTTCTCTCATCTCT TAGCTCCCCTCCAACCTGGGGGGCAGTGGTGTGGAGAAGCCACAGGCCTGAGATTTCATCTGCTCTCCTTCCTGGAGCCCAGAGGAGGGC AGCAGAAGGGGGTGGTGTCTCCAACCCCCCAGCACTGAGGAAGAACGGGGCTCTTCTCATTTCACCCCTCCCTTTCTCCCCTGCCCCCAG GACTGGGCCACTTCTGGGTGGGGCAGTGGGTCCCAGATTGGCTCACACTGAGAATGTAAGAACTACAAACAAAATTTCTATTAAATTAAA >16950_16950_3_CLASRP-CALR_CLASRP_chr19_45563700_ENST00000544944_CALR_chr19_13054559_ENST00000316448_length(amino acids)=300AA_BP=245 MWHEARKHERKLRGMMVDYKKRAERRREYYEKIKKDPAQFLQVHGRACKVHLDSAVALAAESPVNMMPWQGDTNNMIDRFDVRAHLDHIP DYTPPLLTTISPEQESDERKCNYERYRGLVQNDFAGISEEQCLYQIYIDELYGGLQRPSEDEKKKLAEKKASIGYTYEDSTVAKVEKAAE KPEEEESAAEEESNSDEDEVIPDIDVEVDVDELNQEQVADLNKQATTYGMADGDFVSEEEKAMYSEEQRLKEEEEDKKRKEEEEAEDKED -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for CLASRP-CALR |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Tgene | CALR | chr19:45563700 | chr19:13054559 | ENST00000316448 | 0 | 9 | 237_270 | 0 | 418.0 | PPIB |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CLASRP-CALR |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CLASRP-CALR |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0001815 | Primary Myelofibrosis | 2 | CTD_human;GENOMICS_ENGLAND;ORPHANET | |
Tgene | C0026987 | Myelofibrosis | 2 | GENOMICS_ENGLAND;ORPHANET | |
Tgene | C0033975 | Psychotic Disorders | 2 | PSYGENET | |
Tgene | C0036337 | Schizoaffective Disorder | 2 | PSYGENET | |
Tgene | C0040028 | Thrombocythemia, Essential | 2 | CTD_human;ORPHANET | |
Tgene | C0349204 | Nonorganic psychosis | 2 | PSYGENET | |
Tgene | C0004565 | Melanoma, B16 | 1 | CTD_human | |
Tgene | C0005586 | Bipolar Disorder | 1 | PSYGENET | |
Tgene | C0009075 | Melanoma, Cloudman S91 | 1 | CTD_human | |
Tgene | C0009402 | Colorectal Carcinoma | 1 | CTD_human | |
Tgene | C0009404 | Colorectal Neoplasms | 1 | CTD_human | |
Tgene | C0018598 | Melanoma, Harding-Passey | 1 | CTD_human | |
Tgene | C0025205 | Melanoma, Experimental | 1 | CTD_human | |
Tgene | C0027022 | Myeloproliferative disease | 1 | CTD_human | |
Tgene | C0027626 | Neoplasm Invasiveness | 1 | CTD_human | |
Tgene | C0033578 | Prostatic Neoplasms | 1 | CTD_human | |
Tgene | C0033937 | Psychoses, Drug | 1 | PSYGENET | |
Tgene | C0036349 | Paranoid Schizophrenia | 1 | PSYGENET | |
Tgene | C0036939 | Shared Paranoid Disorder | 1 | PSYGENET | |
Tgene | C0151744 | Myocardial Ischemia | 1 | CTD_human | |
Tgene | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human | |
Tgene | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human | |
Tgene | C3277671 | THROMBOCYTHEMIA 1 | 1 | GENOMICS_ENGLAND |