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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHGA-GNAS (FusionGDB2 ID:HG1113TG2778)

Fusion Gene Summary for CHGA-GNAS

check button Fusion gene summary
Fusion gene informationFusion gene name: CHGA-GNAS
Fusion gene ID: hg1113tg2778
HgeneTgene
Gene symbol

CHGA

GNAS

Gene ID

1113

2778

Gene namechromogranin AGNAS complex locus
SynonymsCGAAHO|C20orf45|GNAS1|GPSA|GSA|GSP|NESP|PITA3|POH|SCG6|SgVI
Cytomap('CHGA')('GNAS')

14q32.12

20q13.32

Type of geneprotein-codingprotein-coding
Descriptionchromogranin-ASP-Ibetagranin (N-terminal fragment of chromogranin A)catestatinchromofunginparathyroid secretory protein 1pituitary secretory protein Iprotein ALEXprotein GNASprotein SCG6 (secretogranin VI)G protein subunit alpha Sadenylate cyclase-stimulating G alpha proteinalternative gene product encoded by XL-exonextra large alphas proteinguanine nucleotide binding protein (G protein), alpha
Modification date2020031520200329
UniProtAcc

P10645

.
Ensembl transtripts involved in fusion geneENST00000216492, ENST00000334654, 
ENST00000553866, 
Fusion gene scores* DoF score11 X 15 X 3=495111 X 41 X 18=81918
# samples 15111
** MAII scorelog2(15/495*10)=-1.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(111/81918*10)=-6.20554891117303
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHGA [Title/Abstract] AND GNAS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHGA(93401565)-GNAS(57485813), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHGA

GO:0002551

mast cell chemotaxis

21214543

HgeneCHGA

GO:0032762

mast cell cytokine production

21214543

HgeneCHGA

GO:0033604

negative regulation of catecholamine secretion

15326220

HgeneCHGA

GO:0043303

mast cell degranulation

21214543

HgeneCHGA

GO:0045576

mast cell activation

21214543

HgeneCHGA

GO:0050829

defense response to Gram-negative bacterium

15723172

HgeneCHGA

GO:0050830

defense response to Gram-positive bacterium

15723172



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PCPGTCGA-RW-A686-06ACHGAchr14

93401565

+GNASchr20

57485813

+


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Fusion Gene ORF analysis for CHGA-GNAS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000216492ENST00000313949CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-3UTRENST00000216492ENST00000371075CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-3UTRENST00000216492ENST00000371100CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-3UTRENST00000216492ENST00000464624CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-3UTRENST00000334654ENST00000313949CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-3UTRENST00000334654ENST00000371075CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-3UTRENST00000334654ENST00000371100CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-3UTRENST00000334654ENST00000464624CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-intronENST00000216492ENST00000265620CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-intronENST00000216492ENST00000306090CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-intronENST00000216492ENST00000306120CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-intronENST00000216492ENST00000354359CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-intronENST00000216492ENST00000371081CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-intronENST00000216492ENST00000371085CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-intronENST00000216492ENST00000371095CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-intronENST00000216492ENST00000371098CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-intronENST00000216492ENST00000371099CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-intronENST00000216492ENST00000371102CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-intronENST00000334654ENST00000265620CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-intronENST00000334654ENST00000306090CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-intronENST00000334654ENST00000306120CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-intronENST00000334654ENST00000354359CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-intronENST00000334654ENST00000371081CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-intronENST00000334654ENST00000371085CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-intronENST00000334654ENST00000371095CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-intronENST00000334654ENST00000371098CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-intronENST00000334654ENST00000371099CHGAchr14

93401565

+GNASchr20

57485813

+
3UTR-intronENST00000334654ENST00000371102CHGAchr14

93401565

+GNASchr20

57485813

+
intron-3UTRENST00000553866ENST00000313949CHGAchr14

93401565

+GNASchr20

57485813

+
intron-3UTRENST00000553866ENST00000371075CHGAchr14

93401565

+GNASchr20

57485813

+
intron-3UTRENST00000553866ENST00000371100CHGAchr14

93401565

+GNASchr20

57485813

+
intron-3UTRENST00000553866ENST00000464624CHGAchr14

93401565

+GNASchr20

57485813

+
intron-intronENST00000553866ENST00000265620CHGAchr14

93401565

+GNASchr20

57485813

+
intron-intronENST00000553866ENST00000306090CHGAchr14

93401565

+GNASchr20

57485813

+
intron-intronENST00000553866ENST00000306120CHGAchr14

93401565

+GNASchr20

57485813

+
intron-intronENST00000553866ENST00000354359CHGAchr14

93401565

+GNASchr20

57485813

+
intron-intronENST00000553866ENST00000371081CHGAchr14

93401565

+GNASchr20

57485813

+
intron-intronENST00000553866ENST00000371085CHGAchr14

93401565

+GNASchr20

57485813

+
intron-intronENST00000553866ENST00000371095CHGAchr14

93401565

+GNASchr20

57485813

+
intron-intronENST00000553866ENST00000371098CHGAchr14

93401565

+GNASchr20

57485813

+
intron-intronENST00000553866ENST00000371099CHGAchr14

93401565

+GNASchr20

57485813

+
intron-intronENST00000553866ENST00000371102CHGAchr14

93401565

+GNASchr20

57485813

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CHGA-GNAS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for CHGA-GNAS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:93401565/:57485813)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHGA

P10645

.
FUNCTION: [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172 and PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CHGA-GNAS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CHGA-GNAS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHGA-GNAS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHGA-GNAS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCHGAC0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneCHGAC0031511Pheochromocytoma1CTD_human
HgeneCHGAC0036341Schizophrenia1PSYGENET
HgeneCHGAC1257877Pheochromocytoma, Extra-Adrenal1CTD_human
TgeneC3494506Pseudohypoparathyroidism, Type Ia17CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0242292McCune-Albright Syndrome7CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0016065Polyostotic fibrous dysplasia5CTD_human;ORPHANET
TgeneC1864100PSEUDOHYPOPARATHYROIDISM, TYPE IB5CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC2931404Albright's hereditary osteodystrophy4CTD_human;GENOMICS_ENGLAND
TgeneC0033806Pseudohypoparathyroidism3CTD_human
TgeneC0334041Osteoma cutis3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0014130Endocrine System Diseases2CTD_human
TgeneC0016064Fibrous Dysplasia, Monostotic2ORPHANET
TgeneC0034013Precocious Puberty2CTD_human
TgeneC0221263Cafe-au-Lait Spots2CTD_human
TgeneC0271527Cryptogenic sexual precocity2CTD_human
TgeneC0342543Central Precocious Puberty2CTD_human
TgeneC1504412Testotoxicosis2CTD_human
TgeneC1857451Acth-Independent Macronodular Adrenal Hyperplasia2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC2932716Pseudohypoparathyroidism Type 1C2GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0001206Acromegaly1CTD_human
TgeneC0001624Adrenal Gland Neoplasms1CTD_human
TgeneC0003129Anoxemia1CTD_human
TgeneC0003130Anoxia1CTD_human
TgeneC0008370Cholestasis1GENOMICS_ENGLAND
TgeneC0009438Common Bile Duct Calculi1CTD_human
TgeneC0011573Endogenous depression1PSYGENET
TgeneC0019087Hemorrhagic Disorders1CTD_human
TgeneC0020538Hypertensive disease1CTD_human
TgeneC0020796Profound Mental Retardation1CTD_human
TgeneC0021655Insulin Resistance1CTD_human
TgeneC0023897Liver Diseases, Parasitic1CTD_human
TgeneC0025363Mental Retardation, Psychosocial1CTD_human
TgeneC0027819Neuroblastoma1CTD_human
TgeneC0028754Obesity1CTD_human
TgeneC0029396Heterotopic Ossification1CTD_human
TgeneC0032460Polycystic Ovary Syndrome1CTD_human
TgeneC0033835Pseudopseudohypoparathyroidism1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0035204Respiration Disorders1CTD_human
TgeneC0036341Schizophrenia1PSYGENET
TgeneC0038587Substance Withdrawal Syndrome1CTD_human
TgeneC0039231Tachycardia1CTD_human
TgeneC0080203Tachyarrhythmia1CTD_human
TgeneC0086189Drug Withdrawal Symptoms1CTD_human
TgeneC0087169Withdrawal Symptoms1CTD_human
TgeneC0206698Cholangiocarcinoma1CTD_human
TgeneC0221357Brachydactyly1CTD_human
TgeneC0242184Hypoxia1CTD_human
TgeneC0242216Biliary calculi1CTD_human
TgeneC0345905Intrahepatic Cholangiocarcinoma1CTD_human
TgeneC0346302Growth Hormone-Secreting Pituitary Adenoma1CTD_human
TgeneC0700292Hypoxemia1CTD_human
TgeneC0750887Adrenal Cancer1CTD_human
TgeneC0917816Mental deficiency1CTD_human
TgeneC0920563Insulin Sensitivity1CTD_human
TgeneC1136382Sclerocystic Ovaries1CTD_human
TgeneC2932715Pseudohypoparathyroidism Type 1B1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC3489630Somatotrophinoma, Familial1CTD_human
TgeneC3697137Fibrous dysplasia of bone with intramuscular myxoma1ORPHANET
TgeneC3714756Intellectual Disability1CTD_human
TgeneC3805278Extrahepatic Cholangiocarcinoma1CTD_human