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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CHGA-IGF2 (FusionGDB2 ID:HG1113TG3481) |
Fusion Gene Summary for CHGA-IGF2 |
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Fusion gene information | Fusion gene name: CHGA-IGF2 | Fusion gene ID: hg1113tg3481 | Hgene | Tgene | Gene symbol | CHGA | IGF2 | Gene ID | 1113 | 3481 |
Gene name | chromogranin A | insulin like growth factor 2 | |
Synonyms | CGA | C11orf43|GRDF|IGF-II|PP9974 | |
Cytomap | ('CHGA')('IGF2') 14q32.12 | 11p15.5 | |
Type of gene | protein-coding | protein-coding | |
Description | chromogranin-ASP-Ibetagranin (N-terminal fragment of chromogranin A)catestatinchromofunginparathyroid secretory protein 1pituitary secretory protein I | insulin-like growth factor IIT3M-11-derived growth factorinsulin-like growth factor 2 (somatomedin A)insulin-like growth factor type 2preptin | |
Modification date | 20200315 | 20200322 | |
UniProtAcc | P10645 | . | |
Ensembl transtripts involved in fusion gene | ENST00000553866, ENST00000216492, ENST00000334654, | ||
Fusion gene scores | * DoF score | 11 X 15 X 3=495 | 50 X 61 X 13=39650 |
# samples | 15 | 37 | |
** MAII score | log2(15/495*10)=-1.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(37/39650*10)=-6.74365178496239 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CHGA [Title/Abstract] AND IGF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CHGA(93396090)-IGF2(2152922), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CHGA | GO:0002551 | mast cell chemotaxis | 21214543 |
Hgene | CHGA | GO:0032762 | mast cell cytokine production | 21214543 |
Hgene | CHGA | GO:0033604 | negative regulation of catecholamine secretion | 15326220 |
Hgene | CHGA | GO:0043303 | mast cell degranulation | 21214543 |
Hgene | CHGA | GO:0045576 | mast cell activation | 21214543 |
Hgene | CHGA | GO:0050829 | defense response to Gram-negative bacterium | 15723172 |
Hgene | CHGA | GO:0050830 | defense response to Gram-positive bacterium | 15723172 |
Tgene | IGF2 | GO:0008284 | positive regulation of cell proliferation | 28873464 |
Tgene | IGF2 | GO:0042104 | positive regulation of activated T cell proliferation | 15694994 |
Tgene | IGF2 | GO:0043410 | positive regulation of MAPK cascade | 11500939 |
Tgene | IGF2 | GO:0045840 | positive regulation of mitotic nuclear division | 11500939 |
Tgene | IGF2 | GO:0046628 | positive regulation of insulin receptor signaling pathway | 11500939 |
Tgene | IGF2 | GO:0051897 | positive regulation of protein kinase B signaling | 11500939 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | PCPG | TCGA-QT-A7U0-01A | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
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Fusion Gene ORF analysis for CHGA-IGF2 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000553866 | ENST00000300632 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
3UTR-3UTR | ENST00000553866 | ENST00000381395 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
3UTR-3UTR | ENST00000553866 | ENST00000381406 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
3UTR-3UTR | ENST00000553866 | ENST00000416167 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
3UTR-intron | ENST00000553866 | ENST00000381389 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
3UTR-intron | ENST00000553866 | ENST00000381392 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
3UTR-intron | ENST00000553866 | ENST00000418738 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
3UTR-intron | ENST00000553866 | ENST00000434045 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
5CDS-3UTR | ENST00000216492 | ENST00000300632 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
5CDS-3UTR | ENST00000216492 | ENST00000381395 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
5CDS-3UTR | ENST00000216492 | ENST00000381406 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
5CDS-3UTR | ENST00000216492 | ENST00000416167 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
5CDS-3UTR | ENST00000334654 | ENST00000300632 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
5CDS-3UTR | ENST00000334654 | ENST00000381395 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
5CDS-3UTR | ENST00000334654 | ENST00000381406 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
5CDS-3UTR | ENST00000334654 | ENST00000416167 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
5CDS-intron | ENST00000216492 | ENST00000381389 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
5CDS-intron | ENST00000216492 | ENST00000381392 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
5CDS-intron | ENST00000216492 | ENST00000418738 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
5CDS-intron | ENST00000216492 | ENST00000434045 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
5CDS-intron | ENST00000334654 | ENST00000381389 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
5CDS-intron | ENST00000334654 | ENST00000381392 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
5CDS-intron | ENST00000334654 | ENST00000418738 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
5CDS-intron | ENST00000334654 | ENST00000434045 | CHGA | chr14 | 93396090 | + | IGF2 | chr11 | 2152922 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CHGA-IGF2 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for CHGA-IGF2 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:93396090/:2152922) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
CHGA | . |
FUNCTION: [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172 and PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CHGA-IGF2 |
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Fusion Gene PPI Analysis for CHGA-IGF2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CHGA-IGF2 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CHGA-IGF2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CHGA | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Hgene | CHGA | C0031511 | Pheochromocytoma | 1 | CTD_human |
Hgene | CHGA | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | CHGA | C1257877 | Pheochromocytoma, Extra-Adrenal | 1 | CTD_human |
Tgene | C0004903 | Beckwith-Wiedemann Syndrome | 4 | CTD_human;GENOMICS_ENGLAND | |
Tgene | C0015934 | Fetal Growth Retardation | 3 | CTD_human;GENOMICS_ENGLAND | |
Tgene | C0036341 | Schizophrenia | 2 | PSYGENET | |
Tgene | C0175693 | Russell-Silver syndrome | 2 | CTD_human;GENOMICS_ENGLAND | |
Tgene | C0206686 | Adrenocortical carcinoma | 2 | CTD_human | |
Tgene | C2239176 | Liver carcinoma | 2 | CTD_human | |
Tgene | C0000786 | Spontaneous abortion | 1 | CTD_human | |
Tgene | C0000822 | Abortion, Tubal | 1 | CTD_human | |
Tgene | C0002395 | Alzheimer's Disease | 1 | CTD_human | |
Tgene | C0002871 | Anemia | 1 | CTD_human | |
Tgene | C0004153 | Atherosclerosis | 1 | CTD_human | |
Tgene | C0004352 | Autistic Disorder | 1 | CTD_human | |
Tgene | C0005941 | Bone Diseases, Developmental | 1 | CTD_human | |
Tgene | C0007102 | Malignant tumor of colon | 1 | CTD_human | |
Tgene | C0009241 | Cognition Disorders | 1 | CTD_human | |
Tgene | C0009375 | Colonic Neoplasms | 1 | CTD_human | |
Tgene | C0009402 | Colorectal Carcinoma | 1 | CTD_human | |
Tgene | C0009404 | Colorectal Neoplasms | 1 | CTD_human | |
Tgene | C0011265 | Presenile dementia | 1 | CTD_human | |
Tgene | C0018273 | Growth Disorders | 1 | CTD_human | |
Tgene | C0019284 | Diaphragmatic Hernia | 1 | CTD_human | |
Tgene | C0020224 | Polyhydramnios | 1 | CTD_human | |
Tgene | C0020615 | Hypoglycemia | 1 | CTD_human | |
Tgene | C0023903 | Liver neoplasms | 1 | CTD_human | |
Tgene | C0025261 | Memory Disorders | 1 | CTD_human | |
Tgene | C0027708 | Nephroblastoma | 1 | CTD_human | |
Tgene | C0027746 | Nerve Degeneration | 1 | CTD_human | |
Tgene | C0028754 | Obesity | 1 | CTD_human | |
Tgene | C0030567 | Parkinson Disease | 1 | CTD_human | |
Tgene | C0032045 | Placenta Disorders | 1 | CTD_human | |
Tgene | C0032927 | Precancerous Conditions | 1 | CTD_human | |
Tgene | C0035412 | Rhabdomyosarcoma | 1 | CTD_human | |
Tgene | C0206624 | Hepatoblastoma | 1 | CTD_human | |
Tgene | C0233794 | Memory impairment | 1 | CTD_human | |
Tgene | C0271708 | Fasting Hypoglycemia | 1 | CTD_human | |
Tgene | C0271710 | Reactive hypoglycemia | 1 | CTD_human | |
Tgene | C0276496 | Familial Alzheimer Disease (FAD) | 1 | CTD_human | |
Tgene | C0282313 | Condition, Preneoplastic | 1 | CTD_human | |
Tgene | C0332890 | Congenital hemihypertrophy | 1 | ORPHANET | |
Tgene | C0345904 | Malignant neoplasm of liver | 1 | CTD_human | |
Tgene | C0473935 | Radiolabeled somatostatin analog study | 1 | GENOMICS_ENGLAND | |
Tgene | C0494463 | Alzheimer Disease, Late Onset | 1 | CTD_human | |
Tgene | C0546126 | Acute Confusional Senile Dementia | 1 | CTD_human | |
Tgene | C0678807 | prenatal alcohol exposure | 1 | PSYGENET | |
Tgene | C0750900 | Alzheimer's Disease, Focal Onset | 1 | CTD_human | |
Tgene | C0750901 | Alzheimer Disease, Early Onset | 1 | CTD_human | |
Tgene | C0751292 | Age-Related Memory Disorders | 1 | CTD_human | |
Tgene | C0751293 | Memory Disorder, Semantic | 1 | CTD_human | |
Tgene | C0751294 | Memory Disorder, Spatial | 1 | CTD_human | |
Tgene | C0751295 | Memory Loss | 1 | CTD_human | |
Tgene | C0752347 | Lewy Body Disease | 1 | CTD_human | |
Tgene | C0796160 | MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE | 1 | GENOMICS_ENGLAND | |
Tgene | C1563937 | Atherogenesis | 1 | CTD_human | |
Tgene | C1855652 | Fetus Small for Gestational Age | 1 | GENOMICS_ENGLAND | |
Tgene | C1856184 | HEMIHYPERPLASIA, ISOLATED | 1 | ORPHANET | |
Tgene | C2930471 | Bilateral Wilms Tumor | 1 | CTD_human | |
Tgene | C3830362 | Early Pregnancy Loss | 1 | CTD_human | |
Tgene | C4225307 | GROWTH RESTRICTION, SEVERE, WITH DISTINCTIVE FACIES | 1 | CTD_human;GENOMICS_ENGLAND | |
Tgene | C4552766 | Miscarriage | 1 | CTD_human |