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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:KAT7-F10 (FusionGDB2 ID:HG11143TG2159) |
Fusion Gene Summary for KAT7-F10 |
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Fusion gene information | Fusion gene name: KAT7-F10 | Fusion gene ID: hg11143tg2159 | Hgene | Tgene | Gene symbol | KAT7 | F10 | Gene ID | 11143 | 2159 |
Gene name | lysine acetyltransferase 7 | coagulation factor X | |
Synonyms | HBO1|HBOA|MYST2|ZC2HC7 | FX|FXA | |
Cytomap | ('KAT7')('F10') 17q21.33 | 13q34 | |
Type of gene | protein-coding | protein-coding | |
Description | histone acetyltransferase KAT7K(lysine) acetyltransferase 7MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2MYST histone acetyltransferase 2histone acetyltransferase MYST2histone acetyltransferase binding to ORC1 | coagulation factor XStuart-Prower factorfactor Xfactor Xaprothrombinase | |
Modification date | 20200327 | 20200313 | |
UniProtAcc | . | P00742 | |
Ensembl transtripts involved in fusion gene | ENST00000259021, ENST00000424009, ENST00000435742, ENST00000503935, ENST00000454930, ENST00000509773, ENST00000510819, ENST00000513980, | ||
Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 6 X 7 X 4=168 |
# samples | 7 | 7 | |
** MAII score | log2(7/80*10)=-0.192645077942396 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: KAT7 [Title/Abstract] AND F10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | KAT7(47875920)-F10(113792771), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | KAT7-F10 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. KAT7-F10 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. KAT7-F10 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. KAT7-F10 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. KAT7-F10 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. KAT7-F10 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. KAT7-F10 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. KAT7-F10 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | KAT7 | GO:0006260 | DNA replication | 16387653 |
Hgene | KAT7 | GO:0018393 | internal peptidyl-lysine acetylation | 26221039 |
Hgene | KAT7 | GO:0031098 | stress-activated protein kinase signaling cascade | 21856198 |
Hgene | KAT7 | GO:0043966 | histone H3 acetylation | 16387653 |
Hgene | KAT7 | GO:0043981 | histone H4-K5 acetylation | 16387653 |
Hgene | KAT7 | GO:0043982 | histone H4-K8 acetylation | 16387653 |
Hgene | KAT7 | GO:0043983 | histone H4-K12 acetylation | 16387653 |
Hgene | KAT7 | GO:0043984 | histone H4-K16 acetylation | 16387653 |
Hgene | KAT7 | GO:1900182 | positive regulation of protein localization to nucleus | 24739512 |
Tgene | F10 | GO:0051897 | positive regulation of protein kinase B signaling | 18612547 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | SARC | TCGA-SI-A71O-01A | KAT7 | chr17 | 47875920 | - | F10 | chr13 | 113792771 | + |
ChimerDB4 | SARC | TCGA-SI-A71O-01A | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
ChimerDB4 | SARC | TCGA-SI-A71O-06A | KAT7 | chr17 | 47875920 | - | F10 | chr13 | 113792771 | + |
ChimerDB4 | SARC | TCGA-SI-A71O | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
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Fusion Gene ORF analysis for KAT7-F10 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000259021 | ENST00000483537 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
5CDS-intron | ENST00000259021 | ENST00000483537 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
5CDS-intron | ENST00000424009 | ENST00000483537 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
5CDS-intron | ENST00000424009 | ENST00000483537 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
5CDS-intron | ENST00000435742 | ENST00000483537 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
5CDS-intron | ENST00000435742 | ENST00000483537 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
5CDS-intron | ENST00000503935 | ENST00000483537 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
5CDS-intron | ENST00000503935 | ENST00000483537 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
Frame-shift | ENST00000259021 | ENST00000375551 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
Frame-shift | ENST00000259021 | ENST00000375551 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
Frame-shift | ENST00000259021 | ENST00000375559 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
Frame-shift | ENST00000259021 | ENST00000375559 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
Frame-shift | ENST00000259021 | ENST00000409306 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
Frame-shift | ENST00000259021 | ENST00000409306 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
Frame-shift | ENST00000424009 | ENST00000375551 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
Frame-shift | ENST00000424009 | ENST00000375551 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
Frame-shift | ENST00000424009 | ENST00000375559 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
Frame-shift | ENST00000424009 | ENST00000375559 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
Frame-shift | ENST00000424009 | ENST00000409306 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
Frame-shift | ENST00000424009 | ENST00000409306 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
Frame-shift | ENST00000435742 | ENST00000375551 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
Frame-shift | ENST00000435742 | ENST00000375551 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
Frame-shift | ENST00000435742 | ENST00000375559 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
Frame-shift | ENST00000435742 | ENST00000375559 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
Frame-shift | ENST00000435742 | ENST00000409306 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
Frame-shift | ENST00000435742 | ENST00000409306 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
Frame-shift | ENST00000503935 | ENST00000375551 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
Frame-shift | ENST00000503935 | ENST00000375551 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
Frame-shift | ENST00000503935 | ENST00000375559 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
Frame-shift | ENST00000503935 | ENST00000375559 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
Frame-shift | ENST00000503935 | ENST00000409306 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
Frame-shift | ENST00000503935 | ENST00000409306 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
intron-3CDS | ENST00000454930 | ENST00000375551 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
intron-3CDS | ENST00000454930 | ENST00000375551 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
intron-3CDS | ENST00000454930 | ENST00000375559 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
intron-3CDS | ENST00000454930 | ENST00000375559 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
intron-3CDS | ENST00000454930 | ENST00000409306 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
intron-3CDS | ENST00000454930 | ENST00000409306 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
intron-3CDS | ENST00000509773 | ENST00000375551 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
intron-3CDS | ENST00000509773 | ENST00000375551 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
intron-3CDS | ENST00000509773 | ENST00000375559 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
intron-3CDS | ENST00000509773 | ENST00000375559 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
intron-3CDS | ENST00000509773 | ENST00000409306 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
intron-3CDS | ENST00000509773 | ENST00000409306 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
intron-3CDS | ENST00000510819 | ENST00000375551 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
intron-3CDS | ENST00000510819 | ENST00000375551 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
intron-3CDS | ENST00000510819 | ENST00000375559 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
intron-3CDS | ENST00000510819 | ENST00000375559 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
intron-3CDS | ENST00000510819 | ENST00000409306 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
intron-3CDS | ENST00000510819 | ENST00000409306 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
intron-3CDS | ENST00000513980 | ENST00000375551 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
intron-3CDS | ENST00000513980 | ENST00000375551 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
intron-3CDS | ENST00000513980 | ENST00000375559 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
intron-3CDS | ENST00000513980 | ENST00000375559 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
intron-3CDS | ENST00000513980 | ENST00000409306 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
intron-3CDS | ENST00000513980 | ENST00000409306 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
intron-intron | ENST00000454930 | ENST00000483537 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
intron-intron | ENST00000454930 | ENST00000483537 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
intron-intron | ENST00000509773 | ENST00000483537 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
intron-intron | ENST00000509773 | ENST00000483537 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
intron-intron | ENST00000510819 | ENST00000483537 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
intron-intron | ENST00000510819 | ENST00000483537 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
intron-intron | ENST00000513980 | ENST00000483537 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792771 | + |
intron-intron | ENST00000513980 | ENST00000483537 | KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for KAT7-F10 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + | 3.94E-08 | 1 |
KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + | 3.94E-08 | 1 |
KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + | 3.94E-08 | 1 |
KAT7 | chr17 | 47875920 | + | F10 | chr13 | 113792770 | + | 3.94E-08 | 1 |
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Fusion Protein Features for KAT7-F10 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:47875920/:113792771) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | F10 |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for KAT7-F10 |
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Fusion Gene PPI Analysis for KAT7-F10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for KAT7-F10 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | F10 | P00742 | DB00036 | Coagulation factor VIIa Recombinant Human | Biotech | Approved | |
Tgene | F10 | P00742 | DB01225 | Enoxaparin | Inhibitor | Small molecule | Approved |
Tgene | F10 | P00742 | DB06228 | Rivaroxaban | Antagonist | Small molecule | Approved |
Tgene | F10 | P00742 | DB06605 | Apixaban | Inhibitor | Small molecule | Approved |
Tgene | F10 | P00742 | DB09075 | Edoxaban | Inhibitor | Small molecule | Approved |
Tgene | F10 | P00742 | DB09141 | Protamine sulfate | Biotech | Approved | |
Tgene | F10 | P00742 | DB09332 | Kappadione | Agonist | Small molecule | Approved |
Tgene | F10 | P00742 | DB13149 | Protein S human | Antagonist | Biotech | Approved |
Tgene | F10 | P00742 | DB13152 | Coagulation Factor IX Human | Activator | Biotech | Approved |
Tgene | F10 | P00742 | DB13192 | Antihemophilic factor human | Activator | Biotech | Approved |
Tgene | F10 | P00742 | DB13884 | Albutrepenonacog alfa | Activator | Biotech | Approved |
Tgene | F10 | P00742 | DB13999 | Moroctocog alfa | Activator | Biotech | Approved |
Tgene | F10 | P00742 | DB14738 | Turoctocog alfa pegol | Activator | Biotech | Approved |
Tgene | F10 | P00742 | DB00025 | Antihemophilic factor, human recombinant | Activator | Biotech | Approved|Investigational |
Tgene | F10 | P00742 | DB00100 | Coagulation Factor IX (Recombinant) | Activator | Biotech | Approved|Investigational |
Tgene | F10 | P00742 | DB00569 | Fondaparinux | Inhibitor | Small molecule | Approved|Investigational |
Tgene | F10 | P00742 | DB01109 | Heparin | Inhibitor | Small molecule | Approved|Investigational |
Tgene | F10 | P00742 | DB09109 | Turoctocog alfa | Activator | Biotech | Approved|Investigational |
Tgene | F10 | P00742 | DB09258 | Bemiparin | Antagonist | Small molecule | Approved|Investigational |
Tgene | F10 | P00742 | DB11166 | Antithrombin Alfa | Inhibitor | Biotech | Approved|Investigational |
Tgene | F10 | P00742 | DB12364 | Betrixaban | Inhibitor | Small molecule | Approved|Investigational |
Tgene | F10 | P00742 | DB13150 | Coagulation factor VII human | Activator | Biotech | Approved|Investigational |
Tgene | F10 | P00742 | DB13151 | Anti-inhibitor coagulant complex | Agonist | Biotech | Approved|Investigational |
Tgene | F10 | P00742 | DB13923 | Emicizumab | Activator | Biotech | Approved|Investigational |
Tgene | F10 | P00742 | DB13933 | Nonacog beta pegol | Agonist | Biotech | Approved|Investigational |
Tgene | F10 | P00742 | DB13998 | Lonoctocog alfa | Activator | Biotech | Approved|Investigational |
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Related Diseases for KAT7-F10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0015519 | Factor X Deficiency | 32 | CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C0272327 | Hereditary factor X deficiency disease | 11 | CLINGEN | |
Tgene | C0005779 | Blood Coagulation Disorders | 1 | CTD_human | |
Tgene | C0040053 | Thrombosis | 1 | CTD_human | |
Tgene | C0087086 | Thrombus | 1 | CTD_human |