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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CHGB-CYP17A1 (FusionGDB2 ID:HG1114TG1586) |
Fusion Gene Summary for CHGB-CYP17A1 |
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Fusion gene information | Fusion gene name: CHGB-CYP17A1 | Fusion gene ID: hg1114tg1586 | Hgene | Tgene | Gene symbol | CHGB | CYP17A1 | Gene ID | 1114 | 1586 |
Gene name | chromogranin B | cytochrome P450 family 17 subfamily A member 1 | |
Synonyms | SCG1 | CPT7|CYP17|P450C17|S17AH | |
Cytomap | ('CHGB')('CYP17A1') 20p12.3 | 10q24.32 | |
Type of gene | protein-coding | protein-coding | |
Description | secretogranin-1cgBsecretogranin Bsecretogranin IsgI | steroid 17-alpha-hydroxylase/17,20 lyase17-alpha-hydroxyprogesterone aldolaseCYPXVIIcytochrome P450 17A1cytochrome P450, family 17, subfamily A, polypeptide 1cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasiacytochro | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000378961, ENST00000488832, | ||
Fusion gene scores | * DoF score | 8 X 7 X 2=112 | 3 X 3 X 2=18 |
# samples | 9 | 3 | |
** MAII score | log2(9/112*10)=-0.315501825727929 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CHGB [Title/Abstract] AND CYP17A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CHGB(5904341)-CYP17A1(104597170), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CYP17A1 | GO:0008202 | steroid metabolic process | 22266943 |
Tgene | CYP17A1 | GO:0042446 | hormone biosynthetic process | 22266943 |
Tgene | CYP17A1 | GO:0042448 | progesterone metabolic process | 22266943 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for CHGB-CYP17A1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CHGB-CYP17A1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for CHGB-CYP17A1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:5904341/:104597170) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CHGB-CYP17A1 |
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Fusion Gene PPI Analysis for CHGB-CYP17A1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CHGB-CYP17A1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CHGB-CYP17A1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CHGB | C0036341 | Schizophrenia | 3 | PSYGENET |
Hgene | CHGB | C0221765 | Chronic schizophrenia | 1 | PSYGENET |
Tgene | C0268285 | Adrenal hyperplasia, congenital, type 5 | 19 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C0033578 | Prostatic Neoplasms | 5 | CTD_human | |
Tgene | C0376358 | Malignant neoplasm of prostate | 5 | CTD_human | |
Tgene | C0001627 | Congenital adrenal hyperplasia | 1 | CTD_human;GENOMICS_ENGLAND | |
Tgene | C0002453 | Amenorrhea | 1 | CTD_human | |
Tgene | C0006142 | Malignant neoplasm of breast | 1 | CTD_human | |
Tgene | C0010093 | Corpus Luteum Cyst | 1 | CTD_human | |
Tgene | C0016722 | Frigidity | 1 | CTD_human | |
Tgene | C0020461 | Hyperkalemia | 1 | CTD_human | |
Tgene | C0020540 | Malignant Hypertension | 1 | CTD_human | |
Tgene | C0020594 | Hypoactive Sexual Desire Disorder | 1 | CTD_human | |
Tgene | C0020619 | Hypogonadism | 1 | CTD_human | |
Tgene | C0020635 | Hypopituitarism | 1 | CTD_human | |
Tgene | C0021361 | Female infertility | 1 | CTD_human | |
Tgene | C0021364 | Male infertility | 1 | CTD_human | |
Tgene | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human | |
Tgene | C0027796 | Neuralgia | 1 | CTD_human | |
Tgene | C0028949 | Oligomenorrhea | 1 | CTD_human | |
Tgene | C0029261 | Orgasmic Disorder | 1 | CTD_human | |
Tgene | C0029927 | Ovarian Cysts | 1 | CTD_human | |
Tgene | C0032796 | Postpartum Amenorrhea | 1 | CTD_human | |
Tgene | C0033953 | Psychosexual Disorders | 1 | CTD_human | |
Tgene | C0036902 | Sexual Arousal Disorder | 1 | CTD_human | |
Tgene | C0038279 | Sterility, Postpartum | 1 | CTD_human | |
Tgene | C0038870 | Neuralgia, Supraorbital | 1 | CTD_human | |
Tgene | C0042656 | Neuralgia, Vidian | 1 | CTD_human | |
Tgene | C0234247 | Neuralgia, Atypical | 1 | CTD_human | |
Tgene | C0234249 | Neuralgia, Stump | 1 | CTD_human | |
Tgene | C0242342 | Sheehan Syndrome | 1 | CTD_human | |
Tgene | C0271623 | Hypogonadotropic hypogonadism | 1 | CTD_human | |
Tgene | C0341869 | Subfertility, Female | 1 | CTD_human | |
Tgene | C0400966 | Non-alcoholic Fatty Liver Disease | 1 | CTD_human | |
Tgene | C0423711 | Neuralgia, Perineal | 1 | CTD_human | |
Tgene | C0423712 | Neuralgia, Iliohypogastric Nerve | 1 | CTD_human | |
Tgene | C0678222 | Breast Carcinoma | 1 | CTD_human | |
Tgene | C0751371 | Neuralgia, Ilioinguinal | 1 | CTD_human | |
Tgene | C0751372 | Nerve Pain | 1 | CTD_human | |
Tgene | C0751373 | Paroxysmal Nerve Pain | 1 | CTD_human | |
Tgene | C0848676 | Subfertility, Male | 1 | CTD_human | |
Tgene | C0917730 | Female sterility | 1 | CTD_human | |
Tgene | C0917731 | Male sterility | 1 | CTD_human | |
Tgene | C0948896 | Primary hypogonadism | 1 | CTD_human | |
Tgene | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human | |
Tgene | C1458155 | Mammary Neoplasms | 1 | CTD_human | |
Tgene | C2239176 | Liver carcinoma | 1 | CTD_human | |
Tgene | C3241937 | Nonalcoholic Steatohepatitis | 1 | CTD_human | |
Tgene | C3489396 | Hypogonadism, Isolated Hypogonadotropic | 1 | CTD_human | |
Tgene | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |