![]() |
||||||
|
![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ADAMTS7-ITFG2 (FusionGDB2 ID:HG11173TG55846) |
Fusion Gene Summary for ADAMTS7-ITFG2 |
![]() |
Fusion gene information | Fusion gene name: ADAMTS7-ITFG2 | Fusion gene ID: hg11173tg55846 | Hgene | Tgene | Gene symbol | ADAMTS7 | ITFG2 | Gene ID | 11173 | 55846 |
Gene name | ADAM metallopeptidase with thrombospondin type 1 motif 7 | integrin alpha FG-GAP repeat containing 2 | |
Synonyms | ADAM-TS 7|ADAM-TS7|ADAMTS-7 | FGGAP1|MDS028 | |
Cytomap | ('ADAMTS7')('ITFG2') 15q25.1 | 12p13.33 | |
Type of gene | protein-coding | protein-coding | |
Description | A disintegrin and metalloproteinase with thrombospondin motifs 7COMPasea disintegrin and metalloprotease with thrombospondin motifs-7 preproproteina disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7 | KICSTOR complex protein ITFG2FG-GAP repeat containing 1integrin-alpha FG-GAP repeat-containing protein 2 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q9UKP4 | Q969R8 | |
Ensembl transtripts involved in fusion gene | ENST00000388820, ENST00000566303, | ||
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 11 X 11 X 4=484 |
# samples | 3 | 12 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/484*10)=-2.01197264166608 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ADAMTS7 [Title/Abstract] AND ITFG2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ADAMTS7(79051555)-ITFG2(2949263), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ADAMTS7 | GO:0032331 | negative regulation of chondrocyte differentiation | 22247065 |
Hgene | ADAMTS7 | GO:0071773 | cellular response to BMP stimulus | 22247065 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Top |
Fusion Gene ORF analysis for ADAMTS7-ITFG2 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
Top |
Fusion Genomic Features for ADAMTS7-ITFG2 |
![]() |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Top |
Fusion Protein Features for ADAMTS7-ITFG2 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:79051555/:2949263) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
![]() |
![]() |
Hgene | Tgene |
ADAMTS7 | ITFG2 |
FUNCTION: Metalloprotease that may play a role in the degradation of COMP. {ECO:0000269|PubMed:16585064}. | FUNCTION: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. {ECO:0000269|PubMed:28199306}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for ADAMTS7-ITFG2 |
![]() |
Top |
Fusion Gene PPI Analysis for ADAMTS7-ITFG2 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for ADAMTS7-ITFG2 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for ADAMTS7-ITFG2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ADAMTS7 | C0010054 | Coronary Arteriosclerosis | 1 | CTD_human |
Hgene | ADAMTS7 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
Hgene | ADAMTS7 | C1136382 | Sclerocystic Ovaries | 1 | CTD_human |
Hgene | ADAMTS7 | C1956346 | Coronary Artery Disease | 1 | CTD_human |