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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAP4K5-ADCK1 (FusionGDB2 ID:HG11183TG57143)

Fusion Gene Summary for MAP4K5-ADCK1

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP4K5-ADCK1
Fusion gene ID: hg11183tg57143
HgeneTgene
Gene symbol

MAP4K5

ADCK1

Gene ID

11183

57143

Gene namemitogen-activated protein kinase kinase kinase kinase 5aarF domain containing kinase 1
SynonymsGCKR|KHS|KHS1|MAPKKKK5-
Cytomap('MAP4K5')('ADCK1')

14q22.1

14q24.3

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase kinase 5MAPK/ERK kinase kinase kinase 5MEK kinase kinase 5MEKKK 5germinal center kinase-relatedkinase homologous to SPS1/STE20aarF domain-containing protein kinase 1
Modification date2020031320200313
UniProtAcc

Q9Y4K4

Q86TW2

Ensembl transtripts involved in fusion geneENST00000013125, ENST00000557578, 
Fusion gene scores* DoF score21 X 18 X 10=37806 X 6 X 6=216
# samples 277
** MAII scorelog2(27/3780*10)=-3.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/216*10)=-1.6256044852185
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAP4K5 [Title/Abstract] AND ADCK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAP4K5(50971518)-ADCK1(78353434), # samples:2
Anticipated loss of major functional domain due to fusion event.MAP4K5-ADCK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MAP4K5-ADCK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MAP4K5-ADCK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MAP4K5-ADCK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP4K5

GO:0006468

protein phosphorylation

9038372

HgeneMAP4K5

GO:0035556

intracellular signal transduction

9038372


check buttonFusion gene breakpoints across MAP4K5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ADCK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-XF-AAMW-01AMAP4K5chr14

50971518

-ADCK1chr14

78353434

+


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Fusion Gene ORF analysis for MAP4K5-ADCK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000013125ENST00000556560MAP4K5chr14

50971518

-ADCK1chr14

78353434

+
In-frameENST00000013125ENST00000238561MAP4K5chr14

50971518

-ADCK1chr14

78353434

+
In-frameENST00000013125ENST00000341211MAP4K5chr14

50971518

-ADCK1chr14

78353434

+
intron-3CDSENST00000557578ENST00000238561MAP4K5chr14

50971518

-ADCK1chr14

78353434

+
intron-3CDSENST00000557578ENST00000341211MAP4K5chr14

50971518

-ADCK1chr14

78353434

+
intron-intronENST00000557578ENST00000556560MAP4K5chr14

50971518

-ADCK1chr14

78353434

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000013125MAP4K5chr1450971518-ENST00000238561ADCK1chr1478353434+21974854821633383
ENST00000013125MAP4K5chr1450971518-ENST00000341211ADCK1chr1478353434+21954854821633383

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000013125ENST00000238561MAP4K5chr1450971518-ADCK1chr1478353434+0.0020981980.9979018
ENST00000013125ENST00000341211MAP4K5chr1450971518-ADCK1chr1478353434+0.0021567340.99784327

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Fusion Genomic Features for MAP4K5-ADCK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MAP4K5-ADCK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:50971518/chr14:78353434)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP4K5

Q9Y4K4

ADCK1

Q86TW2

FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9038372}.FUNCTION: Appears to be essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L1 in a kinase-independent manner to regulate essential mitochondrial structural proteins OPA1 and IMMT (PubMed:31125351). The action of this enzyme is not yet clear (Probable). It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) (Probable). {ECO:0000269|PubMed:31125351, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP4K5chr14:50971518chr14:78353434ENST00000013125-33226_3455847.0Nucleotide bindingATP
TgeneADCK1chr14:50971518chr14:78353434ENST00000238561311155_467141524.0DomainProtein kinase
TgeneADCK1chr14:50971518chr14:78353434ENST00000341211210155_46773456.0DomainProtein kinase
TgeneADCK1chr14:50971518chr14:78353434ENST00000238561311161_169141524.0Nucleotide bindingATP
TgeneADCK1chr14:50971518chr14:78353434ENST00000341211210161_16973456.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP4K5chr14:50971518chr14:78353434ENST00000013125-33220_27755847.0DomainProtein kinase
HgeneMAP4K5chr14:50971518chr14:78353434ENST00000013125-332506_81955847.0DomainCNH


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Fusion Gene Sequence for MAP4K5-ADCK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51417_51417_1_MAP4K5-ADCK1_MAP4K5_chr14_50971518_ENST00000013125_ADCK1_chr14_78353434_ENST00000238561_length(transcript)=2197nt_BP=485nt
GGGTGGGGAACGTGGTGCGGCGGCGGCGGCGGCGGCGACTGTACGCGCCTCCGCCGCCCCCGAGAGGACGCGCCGTGCAGCGGCTGAGTG
GCGGCGGCGGCGACGGCAAACCCGGAGCTGCCGGCCGGCGCGCGGGAGGAGGACGCGGGTGCGGTCTAGGAAGTAGGTCCCGGGCTCCGC
GCTCAACAAAGACGGGGCCGCCCCCATTAGACGGAGCTGCGGGCGGAGGCTCCATGTTGGGAAGCGGCGCCGTTCGTGCTTGTTAGCGGG
AATCCGGGAGCCGCGGGGTGAGCTGGCGGGGGCCGGGCCCTAAGTGAAGATGGAGGCCCCGCTGCGGCCTGCCGCGGACATCCTGAGGCG
GAACCCGCAGCAGGACTACGAACTCGTCCAGAGGGTCGGCAGCGGCACCTACGGGGACGTCTATAAGGCCAGAAATGTACACACAGGAGA
GCTGGCTGCAGTAAAAATCATTAAATTGGAGCCTGATCCATGATTTGTTCCAGAGCTTCGATGACACCCCTCTGGGGACGGCCTCCCTGG
CCCAGGTCCACAAGGCAGTGCTGCATGATGGGCGGACGGTGGCCGTGAAGGTCCAGCACCCAAAGGTGCGGGCTCAGAGCTCGAAGGACA
TTCTCCTGATGGAGGTGCTCGTTCTGGCTGTGAAGCAGCTGTTCCCAGAGTTTGAGTTTATGTGGCTTGTGGATGAAGCCAAGAAGAACC
TGCCTTTGGAGCTGGATTTCCTCAATGAAGGGAGGAATGCTGAGAAGGTGTCCCAGATGCTCAGGCATTTTGACTTCTTGAAGGTCCCCC
GAATCCACTGGGACCTGTCCACGGAGCGGGTCCTCCTGATGGAGTTTGTGGATGGCGGGCAGGTCAATGACAGAGACTACATGGAGAGGA
ACAAGATCGACGTCAATGAGATCTCACGCCACCTGGGCAAGATGTATAGTGAGATGATCTTCGTCAATGGCTTCGTGCACTGCGATCCCC
ACCCCGGCAATGTACTGGTGCGGAAGCACCCCGGCACGGGAAAGGCGGAGATTGTCCTGTTGGACCATGGGCTTTACCAGATGCTCACGG
AAGAATTCCGCCTGAATTACTGCCACCTCTGGCAGTCTCTGATCTGGACTGACATGAAGAGAGTGAAGGAGTACAGCCAGCGACTGGGAG
CCGGGGATCTCTACCCCTTGTTTGCCTGCATGCTGACGGCGCGATCGTGGGACTCGGTCAACAGAGGCATCAGCCAAGCTCCCGTCACTG
CCACTGAGGACTTAGAGATTCGCAACAACGCGGCCAACTACCTCCCCCAGATCAGCCATCTCCTCAACCACGTGCCGCGCCAGATGCTGC
TCATCTTGAAGACCAACGACCTGCTGCGTGGCATTGAGGCCGCCCTGGGCACCCGCGCCAGCGCCAGCTCCTTTCTCAACATGTCACGTT
GCTGCATCAGAGCGCTAGCTGAGCACAAGAAGAAGAATACCTGTTCATTCTTCAGAAGGACCCAGATCTCTTTCAGCGAGGCCTTCAACT
TATGGCAGATCAACCTCCATGAGCTCATCCTGCGTGTGAAGGGGTTGAAGCTGGCTGACCGGGTCTTGGCCCTAATATGCTGGCTGTTCC
CTGCTCCACTCTGAGTGGAATTGCTCTCCCTGCCCCATTCTGGTGTCTTTCCACTCCTCAGCCCCTCATCTTGCCTCCACCCAGCTGCTC
CATTTTTGCCACATCGTGGCCCGCAGCCCCAGAGTCACTGTCCATGTCACCATCCTTCTCCTCCTTTGGAATCCTCTCCGCACACTGTGG
CCCTTGTCTCAGGGCCCACAAGCTGAACTGTGGCATAGCTCTCTCTTCTTCTCCAAGAAGACTCAGCAGCCTACATTCCCATTCCTGGTA
TGTGCCATTGGGTTGGATGTCCCCACTACTTCCGTTAACCCTTCCCATTGTCAAGATGTGCCACGGGTGCCACTGGGGGCACACTGAACT
TGTAGGGAGTGTGATTTTGTTGGAGGTGCACATGGTCTCTGAATTTGACAGAGAACACCTTCCCTTTCCTTGCCATGTCACCCTCCAGAG
GAAGTCACACCTCAGCGAGGTGGTTTGGCATCTGGGGCCAACTCCATTACAGCTATGAGCTCACTGCTGTCAGTGACGTTTGGTGTTTTC

>51417_51417_1_MAP4K5-ADCK1_MAP4K5_chr14_50971518_ENST00000013125_ADCK1_chr14_78353434_ENST00000238561_length(amino acids)=383AA_BP=1
MIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHPKVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEG
RNAEKVSQMLRHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHP
GTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNA
ANYLPQISHLLNHVPRQMLLILKTNDLLRGIEAALGTRASASSFLNMSRCCIRALAEHKKKNTCSFFRRTQISFSEAFNLWQINLHELIL

--------------------------------------------------------------
>51417_51417_2_MAP4K5-ADCK1_MAP4K5_chr14_50971518_ENST00000013125_ADCK1_chr14_78353434_ENST00000341211_length(transcript)=2195nt_BP=485nt
GGGTGGGGAACGTGGTGCGGCGGCGGCGGCGGCGGCGACTGTACGCGCCTCCGCCGCCCCCGAGAGGACGCGCCGTGCAGCGGCTGAGTG
GCGGCGGCGGCGACGGCAAACCCGGAGCTGCCGGCCGGCGCGCGGGAGGAGGACGCGGGTGCGGTCTAGGAAGTAGGTCCCGGGCTCCGC
GCTCAACAAAGACGGGGCCGCCCCCATTAGACGGAGCTGCGGGCGGAGGCTCCATGTTGGGAAGCGGCGCCGTTCGTGCTTGTTAGCGGG
AATCCGGGAGCCGCGGGGTGAGCTGGCGGGGGCCGGGCCCTAAGTGAAGATGGAGGCCCCGCTGCGGCCTGCCGCGGACATCCTGAGGCG
GAACCCGCAGCAGGACTACGAACTCGTCCAGAGGGTCGGCAGCGGCACCTACGGGGACGTCTATAAGGCCAGAAATGTACACACAGGAGA
GCTGGCTGCAGTAAAAATCATTAAATTGGAGCCTGATCCATGATTTGTTCCAGAGCTTCGATGACACCCCTCTGGGGACGGCCTCCCTGG
CCCAGGTCCACAAGGCAGTGCTGCATGATGGGCGGACGGTGGCCGTGAAGGTCCAGCACCCAAAGGTGCGGGCTCAGAGCTCGAAGGACA
TTCTCCTGATGGAGGTGCTCGTTCTGGCTGTGAAGCAGCTGTTCCCAGAGTTTGAGTTTATGTGGCTTGTGGATGAAGCCAAGAAGAACC
TGCCTTTGGAGCTGGATTTCCTCAATGAAGGGAGGAATGCTGAGAAGGTGTCCCAGATGCTCAGGCATTTTGACTTCTTGAAGGTCCCCC
GAATCCACTGGGACCTGTCCACGGAGCGGGTCCTCCTGATGGAGTTTGTGGATGGCGGGCAGGTCAATGACAGAGACTACATGGAGAGGA
ACAAGATCGACGTCAATGAGATCTCACGCCACCTGGGCAAGATGTATAGTGAGATGATCTTCGTCAATGGCTTCGTGCACTGCGATCCCC
ACCCCGGCAATGTACTGGTGCGGAAGCACCCCGGCACGGGAAAGGCGGAGATTGTCCTGTTGGACCATGGGCTTTACCAGATGCTCACGG
AAGAATTCCGCCTGAATTACTGCCACCTCTGGCAGTCTCTGATCTGGACTGACATGAAGAGAGTGAAGGAGTACAGCCAGCGACTGGGAG
CCGGGGATCTCTACCCCTTGTTTGCCTGCATGCTGACGGCGCGATCGTGGGACTCGGTCAACAGAGGCATCAGCCAAGCTCCCGTCACTG
CCACTGAGGACTTAGAGATTCGCAACAACGCGGCCAACTACCTCCCCCAGATCAGCCATCTCCTCAACCACGTGCCGCGCCAGATGCTGC
TCATCTTGAAGACCAACGACCTGCTGCGTGGCATTGAGGCCGCCCTGGGCACCCGCGCCAGCGCCAGCTCCTTTCTCAACATGTCACGTT
GCTGCATCAGAGCGCTAGCTGAGCACAAGAAGAAGAATACCTGTTCATTCTTCAGAAGGACCCAGATCTCTTTCAGCGAGGCCTTCAACT
TATGGCAGATCAACCTCCATGAGCTCATCCTGCGTGTGAAGGGGTTGAAGCTGGCTGACCGGGTCTTGGCCCTAATATGCTGGCTGTTCC
CTGCTCCACTCTGAGTGGAATTGCTCTCCCTGCCCCATTCTGGTGTCTTTCCACTCCTCAGCCCCTCATCTTGCCTCCACCCAGCTGCTC
CATTTTTGCCACATCGTGGCCCGCAGCCCCAGAGTCACTGTCCATGTCACCATCCTTCTCCTCCTTTGGAATCCTCTCCGCACACTGTGG
CCCTTGTCTCAGGGCCCACAAGCTGAACTGTGGCATAGCTCTCTCTTCTTCTCCAAGAAGACTCAGCAGCCTACATTCCCATTCCTGGTA
TGTGCCATTGGGTTGGATGTCCCCACTACTTCCGTTAACCCTTCCCATTGTCAAGATGTGCCACGGGTGCCACTGGGGGCACACTGAACT
TGTAGGGAGTGTGATTTTGTTGGAGGTGCACATGGTCTCTGAATTTGACAGAGAACACCTTCCCTTTCCTTGCCATGTCACCCTCCAGAG
GAAGTCACACCTCAGCGAGGTGGTTTGGCATCTGGGGCCAACTCCATTACAGCTATGAGCTCACTGCTGTCAGTGACGTTTGGTGTTTTC

>51417_51417_2_MAP4K5-ADCK1_MAP4K5_chr14_50971518_ENST00000013125_ADCK1_chr14_78353434_ENST00000341211_length(amino acids)=383AA_BP=1
MIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHPKVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEG
RNAEKVSQMLRHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHP
GTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNA
ANYLPQISHLLNHVPRQMLLILKTNDLLRGIEAALGTRASASSFLNMSRCCIRALAEHKKKNTCSFFRRTQISFSEAFNLWQINLHELIL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MAP4K5-ADCK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAP4K5-ADCK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMAP4K5Q9Y4K4DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for MAP4K5-ADCK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource