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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHEK2-C22orf31 (FusionGDB2 ID:HG11200TG25770)

Fusion Gene Summary for CHEK2-C22orf31

check button Fusion gene summary
Fusion gene informationFusion gene name: CHEK2-C22orf31
Fusion gene ID: hg11200tg25770
HgeneTgene
Gene symbol

CHEK2

C22orf31

Gene ID

11200

25770

Gene namecheckpoint kinase 2chromosome 22 open reading frame 31
SynonymsCDS1|CHK2|HuCds1|LFS2|PP1425|RAD53|hCds1HS747E2A|bK747E2.1
Cytomap('CHEK2')('C22orf31')

22q12.1

22q12.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase Chk2CHK2 checkpoint homologcds1 homologcheckpoint-like protein CHK2uncharacterized protein C22orf31
Modification date2020032020200313
UniProtAcc.

O95567

Ensembl transtripts involved in fusion geneENST00000544772, ENST00000328354, 
ENST00000348295, ENST00000382565, 
ENST00000382578, ENST00000382580, 
ENST00000405598, ENST00000382566, 
ENST00000402731, ENST00000403642, 
ENST00000404276, ENST00000464581, 
Fusion gene scores* DoF score3 X 3 X 3=275 X 3 X 4=60
# samples 35
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHEK2 [Title/Abstract] AND C22orf31 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHEK2(29130391)-C22orf31(29456831), # samples:2
Anticipated loss of major functional domain due to fusion event.CHEK2-C22orf31 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHEK2-C22orf31 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CHEK2-C22orf31 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CHEK2-C22orf31 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CHEK2-C22orf31 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
CHEK2-C22orf31 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHEK2

GO:0006355

regulation of transcription, DNA-templated

12717439

HgeneCHEK2

GO:0006468

protein phosphorylation

12717439

HgeneCHEK2

GO:0006974

cellular response to DNA damage stimulus

24550317

HgeneCHEK2

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

12402044

HgeneCHEK2

GO:0042770

signal transduction in response to DNA damage

14744935

HgeneCHEK2

GO:0045893

positive regulation of transcription, DNA-templated

17101782

HgeneCHEK2

GO:0046777

protein autophosphorylation

16794575|18644861

HgeneCHEK2

GO:0050821

protein stabilization

12717439


check buttonFusion gene breakpoints across CHEK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across C22orf31 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-NC-A5HD-01ACHEK2chr22

29130391

-C22orf31chr22

29456831

-


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Fusion Gene ORF analysis for CHEK2-C22orf31

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000544772ENST00000216071CHEK2chr22

29130391

-C22orf31chr22

29456831

-
Frame-shiftENST00000328354ENST00000216071CHEK2chr22

29130391

-C22orf31chr22

29456831

-
Frame-shiftENST00000348295ENST00000216071CHEK2chr22

29130391

-C22orf31chr22

29456831

-
Frame-shiftENST00000382565ENST00000216071CHEK2chr22

29130391

-C22orf31chr22

29456831

-
Frame-shiftENST00000382578ENST00000216071CHEK2chr22

29130391

-C22orf31chr22

29456831

-
Frame-shiftENST00000382580ENST00000216071CHEK2chr22

29130391

-C22orf31chr22

29456831

-
Frame-shiftENST00000405598ENST00000216071CHEK2chr22

29130391

-C22orf31chr22

29456831

-
In-frameENST00000382566ENST00000216071CHEK2chr22

29130391

-C22orf31chr22

29456831

-
In-frameENST00000402731ENST00000216071CHEK2chr22

29130391

-C22orf31chr22

29456831

-
In-frameENST00000403642ENST00000216071CHEK2chr22

29130391

-C22orf31chr22

29456831

-
In-frameENST00000404276ENST00000216071CHEK2chr22

29130391

-C22orf31chr22

29456831

-
intron-3CDSENST00000464581ENST00000216071CHEK2chr22

29130391

-C22orf31chr22

29456831

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000382566CHEK2chr2229130391-ENST00000216071C22orf31chr2229456831-13313912951260321
ENST00000404276CHEK2chr2229130391-ENST00000216071C22orf31chr2229456831-12593192231188321
ENST00000402731CHEK2chr2229130391-ENST00000216071C22orf31chr2229456831-12593192231188321
ENST00000403642CHEK2chr2229130391-ENST00000216071C22orf31chr2229456831-12593192231188321

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000382566ENST00000216071CHEK2chr2229130391-C22orf31chr2229456831-0.1175821050.8824179
ENST00000404276ENST00000216071CHEK2chr2229130391-C22orf31chr2229456831-0.118937380.8810626
ENST00000402731ENST00000216071CHEK2chr2229130391-C22orf31chr2229456831-0.118937380.8810626
ENST00000403642ENST00000216071CHEK2chr2229130391-C22orf31chr2229456831-0.118937380.8810626

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Fusion Genomic Features for CHEK2-C22orf31


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CHEK2-C22orf31


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:29130391/chr22:29456831)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.C22orf31

O95567

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHEK2chr22:29130391chr22:29456831ENST00000328354-215113_175106544.0DomainFHA
HgeneCHEK2chr22:29130391chr22:29456831ENST00000328354-215220_486106544.0DomainProtein kinase
HgeneCHEK2chr22:29130391chr22:29456831ENST00000348295-214113_175106515.0DomainFHA
HgeneCHEK2chr22:29130391chr22:29456831ENST00000348295-214220_486106515.0DomainProtein kinase
HgeneCHEK2chr22:29130391chr22:29456831ENST00000382566-214113_175106276.6666666666667DomainFHA
HgeneCHEK2chr22:29130391chr22:29456831ENST00000382566-214220_486106276.6666666666667DomainProtein kinase
HgeneCHEK2chr22:29130391chr22:29456831ENST00000382578-213113_175106453.0DomainFHA
HgeneCHEK2chr22:29130391chr22:29456831ENST00000382578-213220_486106453.0DomainProtein kinase
HgeneCHEK2chr22:29130391chr22:29456831ENST00000382580-216113_175106587.0DomainFHA
HgeneCHEK2chr22:29130391chr22:29456831ENST00000382580-216220_486106587.0DomainProtein kinase
HgeneCHEK2chr22:29130391chr22:29456831ENST00000402731-113113_175106515.0DomainFHA
HgeneCHEK2chr22:29130391chr22:29456831ENST00000402731-113220_486106515.0DomainProtein kinase
HgeneCHEK2chr22:29130391chr22:29456831ENST00000403642-112113_175106453.0DomainFHA
HgeneCHEK2chr22:29130391chr22:29456831ENST00000403642-112220_486106453.0DomainProtein kinase
HgeneCHEK2chr22:29130391chr22:29456831ENST00000404276-114113_175106544.0DomainFHA
HgeneCHEK2chr22:29130391chr22:29456831ENST00000404276-114220_486106544.0DomainProtein kinase
HgeneCHEK2chr22:29130391chr22:29456831ENST00000405598-316113_175106544.0DomainFHA
HgeneCHEK2chr22:29130391chr22:29456831ENST00000405598-316220_486106544.0DomainProtein kinase
HgeneCHEK2chr22:29130391chr22:29456831ENST00000544772-216113_1750323.0DomainFHA
HgeneCHEK2chr22:29130391chr22:29456831ENST00000544772-216220_4860323.0DomainProtein kinase
HgeneCHEK2chr22:29130391chr22:29456831ENST00000328354-215227_234106544.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000328354-215302_308106544.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000328354-215351_352106544.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000348295-214227_234106515.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000348295-214302_308106515.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000348295-214351_352106515.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000382566-214227_234106276.6666666666667Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000382566-214302_308106276.6666666666667Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000382566-214351_352106276.6666666666667Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000382578-213227_234106453.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000382578-213302_308106453.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000382578-213351_352106453.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000382580-216227_234106587.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000382580-216302_308106587.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000382580-216351_352106587.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000402731-113227_234106515.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000402731-113302_308106515.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000402731-113351_352106515.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000403642-112227_234106453.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000403642-112302_308106453.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000403642-112351_352106453.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000404276-114227_234106544.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000404276-114302_308106544.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000404276-114351_352106544.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000405598-316227_234106544.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000405598-316302_308106544.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000405598-316351_352106544.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000544772-216227_2340323.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000544772-216302_3080323.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000544772-216351_3520323.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29130391chr22:29456831ENST00000328354-215368_394106544.0RegionNote=T-loop/activation segment
HgeneCHEK2chr22:29130391chr22:29456831ENST00000348295-214368_394106515.0RegionNote=T-loop/activation segment
HgeneCHEK2chr22:29130391chr22:29456831ENST00000382566-214368_394106276.6666666666667RegionNote=T-loop/activation segment
HgeneCHEK2chr22:29130391chr22:29456831ENST00000382578-213368_394106453.0RegionNote=T-loop/activation segment
HgeneCHEK2chr22:29130391chr22:29456831ENST00000382580-216368_394106587.0RegionNote=T-loop/activation segment
HgeneCHEK2chr22:29130391chr22:29456831ENST00000402731-113368_394106515.0RegionNote=T-loop/activation segment
HgeneCHEK2chr22:29130391chr22:29456831ENST00000403642-112368_394106453.0RegionNote=T-loop/activation segment
HgeneCHEK2chr22:29130391chr22:29456831ENST00000404276-114368_394106544.0RegionNote=T-loop/activation segment
HgeneCHEK2chr22:29130391chr22:29456831ENST00000405598-316368_394106544.0RegionNote=T-loop/activation segment
HgeneCHEK2chr22:29130391chr22:29456831ENST00000544772-216368_3940323.0RegionNote=T-loop/activation segment


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Fusion Gene Sequence for CHEK2-C22orf31


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16418_16418_1_CHEK2-C22orf31_CHEK2_chr22_29130391_ENST00000382566_C22orf31_chr22_29456831_ENST00000216071_length(transcript)=1331nt_BP=391nt
GCAGGTTTAGCGCCACTCTGCTGGCTGAGGCTGCGGAGAGTGTGCGGCTCCAGGTGGGCTCACGCGGTCGTGATGTCTCGGGAGTCGGAT
GTTGAGGCTCAGCAGTCTCATGGCAGCAGTGCCTGTTCACAGCCCCATGGCAGCGTTACCCAGTCCCAAGGCTCCTCCTCACAGTCCCAG
GGCATATCCAGCTCCTCTACCAGCACGATGCCAAACTCCAGCCAGTCCTCTCACTCCAGCTCTGGGACACTGAGCTCCTTAGAGACAGTG
TCCACTCAGGAACTCTATTCTATTCCTGAGGACCAAGAACCTGAGGACCAAGAACCTGAGGAGCCTACCCCTGCCCCCTGGGCTCGATTA
TGGGCCCTTCAGGATGGATTTGCCAATCTTGCACCCAATCAATGTGAGACGAGACCCCAGCATCCCTATCTATGGACTCCGACAGTCCAT
CTTATTAAATACCAGGCTTCAGGACTGCTATGTGGACTCACCGGCTCTCACCAACATCTGGATGGCCAGAACATGTGCAAAGCAGAACAT
TAATGCCCCAGCACCAGCTACCACTTCCTCTTGGGAAGTTGTAAGGAACCCATTAATTGCCAGTTCCTTCTCCCTGGTTAAGCTTGTACT
CAGGCGGCAACTGAAGAATAAGTGCTGCCCACCACCATGCAAGTTTGGAGAAGGAAAACTCTCGAAGAGATTAAAGCACAAGGACGATTC
AGTGATGAAAGCCACCCAGCAGGCCAGGAAAAGAAACTTCATCAGTTCCAAGAGCAAGCAGCCAGCAGGGCATAGGAGGCCTGCAGGAGG
CATCAGAGAGAGTAAAGAAAGTTCAAAGGAGAAAAAACTAACAGTCCGCCAAGATCTTGAGGACAGATATGCTGAACATGTGGCTGCCAC
CCAAGCGCTACCCCAGGACAGTGGGACAGCAGCCTGGAAGGGCCGAGTGTTGCTTCCTGAAACCCAAAAGAGACAGCAGTTGTCGGAGGA
CACGCTAACCATCCATGGTCTCCCCACAGAGGGTTACCAGGCTCTGTACCACGCTGTGGTGGAGCCAATGCTGTGGAATCCTTCAGGGAC
CCCCAAGAGGTACAGCCTGGAGCTGGGCAAGGCCATTAAACAAAAGCTCTGGGAGGCTCTTTGCAGTCAGGGTGCCATCTCTGAAGGTGC
TCAGAGGGACCGGTTCCCTGGCAGGAAGCAGCCAGGTGTCCACGAGGAGCCTGTACTCAAGAAATGGCCCAAGTTAAAGAGCAAAAAATA

>16418_16418_1_CHEK2-C22orf31_CHEK2_chr22_29130391_ENST00000382566_C22orf31_chr22_29456831_ENST00000216071_length(amino acids)=321AA_BP=25
MRTKNLRTKNLRSLPLPPGLDYGPFRMDLPILHPINVRRDPSIPIYGLRQSILLNTRLQDCYVDSPALTNIWMARTCAKQNINAPAPATT
SSWEVVRNPLIASSFSLVKLVLRRQLKNKCCPPPCKFGEGKLSKRLKHKDDSVMKATQQARKRNFISSKSKQPAGHRRPAGGIRESKESS
KEKKLTVRQDLEDRYAEHVAATQALPQDSGTAAWKGRVLLPETQKRQQLSEDTLTIHGLPTEGYQALYHAVVEPMLWNPSGTPKRYSLEL

--------------------------------------------------------------
>16418_16418_2_CHEK2-C22orf31_CHEK2_chr22_29130391_ENST00000402731_C22orf31_chr22_29456831_ENST00000216071_length(transcript)=1259nt_BP=319nt
ATGTCTCGGGAGTCGGATGTTGAGGCTCAGCAGTCTCATGGCAGCAGTGCCTGTTCACAGCCCCATGGCAGCGTTACCCAGTCCCAAGGC
TCCTCCTCACAGTCCCAGGGCATATCCAGCTCCTCTACCAGCACGATGCCAAACTCCAGCCAGTCCTCTCACTCCAGCTCTGGGACACTG
AGCTCCTTAGAGACAGTGTCCACTCAGGAACTCTATTCTATTCCTGAGGACCAAGAACCTGAGGACCAAGAACCTGAGGAGCCTACCCCT
GCCCCCTGGGCTCGATTATGGGCCCTTCAGGATGGATTTGCCAATCTTGCACCCAATCAATGTGAGACGAGACCCCAGCATCCCTATCTA
TGGACTCCGACAGTCCATCTTATTAAATACCAGGCTTCAGGACTGCTATGTGGACTCACCGGCTCTCACCAACATCTGGATGGCCAGAAC
ATGTGCAAAGCAGAACATTAATGCCCCAGCACCAGCTACCACTTCCTCTTGGGAAGTTGTAAGGAACCCATTAATTGCCAGTTCCTTCTC
CCTGGTTAAGCTTGTACTCAGGCGGCAACTGAAGAATAAGTGCTGCCCACCACCATGCAAGTTTGGAGAAGGAAAACTCTCGAAGAGATT
AAAGCACAAGGACGATTCAGTGATGAAAGCCACCCAGCAGGCCAGGAAAAGAAACTTCATCAGTTCCAAGAGCAAGCAGCCAGCAGGGCA
TAGGAGGCCTGCAGGAGGCATCAGAGAGAGTAAAGAAAGTTCAAAGGAGAAAAAACTAACAGTCCGCCAAGATCTTGAGGACAGATATGC
TGAACATGTGGCTGCCACCCAAGCGCTACCCCAGGACAGTGGGACAGCAGCCTGGAAGGGCCGAGTGTTGCTTCCTGAAACCCAAAAGAG
ACAGCAGTTGTCGGAGGACACGCTAACCATCCATGGTCTCCCCACAGAGGGTTACCAGGCTCTGTACCACGCTGTGGTGGAGCCAATGCT
GTGGAATCCTTCAGGGACCCCCAAGAGGTACAGCCTGGAGCTGGGCAAGGCCATTAAACAAAAGCTCTGGGAGGCTCTTTGCAGTCAGGG
TGCCATCTCTGAAGGTGCTCAGAGGGACCGGTTCCCTGGCAGGAAGCAGCCAGGTGTCCACGAGGAGCCTGTACTCAAGAAATGGCCCAA

>16418_16418_2_CHEK2-C22orf31_CHEK2_chr22_29130391_ENST00000402731_C22orf31_chr22_29456831_ENST00000216071_length(amino acids)=321AA_BP=25
MRTKNLRTKNLRSLPLPPGLDYGPFRMDLPILHPINVRRDPSIPIYGLRQSILLNTRLQDCYVDSPALTNIWMARTCAKQNINAPAPATT
SSWEVVRNPLIASSFSLVKLVLRRQLKNKCCPPPCKFGEGKLSKRLKHKDDSVMKATQQARKRNFISSKSKQPAGHRRPAGGIRESKESS
KEKKLTVRQDLEDRYAEHVAATQALPQDSGTAAWKGRVLLPETQKRQQLSEDTLTIHGLPTEGYQALYHAVVEPMLWNPSGTPKRYSLEL

--------------------------------------------------------------
>16418_16418_3_CHEK2-C22orf31_CHEK2_chr22_29130391_ENST00000403642_C22orf31_chr22_29456831_ENST00000216071_length(transcript)=1259nt_BP=319nt
ATGTCTCGGGAGTCGGATGTTGAGGCTCAGCAGTCTCATGGCAGCAGTGCCTGTTCACAGCCCCATGGCAGCGTTACCCAGTCCCAAGGC
TCCTCCTCACAGTCCCAGGGCATATCCAGCTCCTCTACCAGCACGATGCCAAACTCCAGCCAGTCCTCTCACTCCAGCTCTGGGACACTG
AGCTCCTTAGAGACAGTGTCCACTCAGGAACTCTATTCTATTCCTGAGGACCAAGAACCTGAGGACCAAGAACCTGAGGAGCCTACCCCT
GCCCCCTGGGCTCGATTATGGGCCCTTCAGGATGGATTTGCCAATCTTGCACCCAATCAATGTGAGACGAGACCCCAGCATCCCTATCTA
TGGACTCCGACAGTCCATCTTATTAAATACCAGGCTTCAGGACTGCTATGTGGACTCACCGGCTCTCACCAACATCTGGATGGCCAGAAC
ATGTGCAAAGCAGAACATTAATGCCCCAGCACCAGCTACCACTTCCTCTTGGGAAGTTGTAAGGAACCCATTAATTGCCAGTTCCTTCTC
CCTGGTTAAGCTTGTACTCAGGCGGCAACTGAAGAATAAGTGCTGCCCACCACCATGCAAGTTTGGAGAAGGAAAACTCTCGAAGAGATT
AAAGCACAAGGACGATTCAGTGATGAAAGCCACCCAGCAGGCCAGGAAAAGAAACTTCATCAGTTCCAAGAGCAAGCAGCCAGCAGGGCA
TAGGAGGCCTGCAGGAGGCATCAGAGAGAGTAAAGAAAGTTCAAAGGAGAAAAAACTAACAGTCCGCCAAGATCTTGAGGACAGATATGC
TGAACATGTGGCTGCCACCCAAGCGCTACCCCAGGACAGTGGGACAGCAGCCTGGAAGGGCCGAGTGTTGCTTCCTGAAACCCAAAAGAG
ACAGCAGTTGTCGGAGGACACGCTAACCATCCATGGTCTCCCCACAGAGGGTTACCAGGCTCTGTACCACGCTGTGGTGGAGCCAATGCT
GTGGAATCCTTCAGGGACCCCCAAGAGGTACAGCCTGGAGCTGGGCAAGGCCATTAAACAAAAGCTCTGGGAGGCTCTTTGCAGTCAGGG
TGCCATCTCTGAAGGTGCTCAGAGGGACCGGTTCCCTGGCAGGAAGCAGCCAGGTGTCCACGAGGAGCCTGTACTCAAGAAATGGCCCAA

>16418_16418_3_CHEK2-C22orf31_CHEK2_chr22_29130391_ENST00000403642_C22orf31_chr22_29456831_ENST00000216071_length(amino acids)=321AA_BP=25
MRTKNLRTKNLRSLPLPPGLDYGPFRMDLPILHPINVRRDPSIPIYGLRQSILLNTRLQDCYVDSPALTNIWMARTCAKQNINAPAPATT
SSWEVVRNPLIASSFSLVKLVLRRQLKNKCCPPPCKFGEGKLSKRLKHKDDSVMKATQQARKRNFISSKSKQPAGHRRPAGGIRESKESS
KEKKLTVRQDLEDRYAEHVAATQALPQDSGTAAWKGRVLLPETQKRQQLSEDTLTIHGLPTEGYQALYHAVVEPMLWNPSGTPKRYSLEL

--------------------------------------------------------------
>16418_16418_4_CHEK2-C22orf31_CHEK2_chr22_29130391_ENST00000404276_C22orf31_chr22_29456831_ENST00000216071_length(transcript)=1259nt_BP=319nt
ATGTCTCGGGAGTCGGATGTTGAGGCTCAGCAGTCTCATGGCAGCAGTGCCTGTTCACAGCCCCATGGCAGCGTTACCCAGTCCCAAGGC
TCCTCCTCACAGTCCCAGGGCATATCCAGCTCCTCTACCAGCACGATGCCAAACTCCAGCCAGTCCTCTCACTCCAGCTCTGGGACACTG
AGCTCCTTAGAGACAGTGTCCACTCAGGAACTCTATTCTATTCCTGAGGACCAAGAACCTGAGGACCAAGAACCTGAGGAGCCTACCCCT
GCCCCCTGGGCTCGATTATGGGCCCTTCAGGATGGATTTGCCAATCTTGCACCCAATCAATGTGAGACGAGACCCCAGCATCCCTATCTA
TGGACTCCGACAGTCCATCTTATTAAATACCAGGCTTCAGGACTGCTATGTGGACTCACCGGCTCTCACCAACATCTGGATGGCCAGAAC
ATGTGCAAAGCAGAACATTAATGCCCCAGCACCAGCTACCACTTCCTCTTGGGAAGTTGTAAGGAACCCATTAATTGCCAGTTCCTTCTC
CCTGGTTAAGCTTGTACTCAGGCGGCAACTGAAGAATAAGTGCTGCCCACCACCATGCAAGTTTGGAGAAGGAAAACTCTCGAAGAGATT
AAAGCACAAGGACGATTCAGTGATGAAAGCCACCCAGCAGGCCAGGAAAAGAAACTTCATCAGTTCCAAGAGCAAGCAGCCAGCAGGGCA
TAGGAGGCCTGCAGGAGGCATCAGAGAGAGTAAAGAAAGTTCAAAGGAGAAAAAACTAACAGTCCGCCAAGATCTTGAGGACAGATATGC
TGAACATGTGGCTGCCACCCAAGCGCTACCCCAGGACAGTGGGACAGCAGCCTGGAAGGGCCGAGTGTTGCTTCCTGAAACCCAAAAGAG
ACAGCAGTTGTCGGAGGACACGCTAACCATCCATGGTCTCCCCACAGAGGGTTACCAGGCTCTGTACCACGCTGTGGTGGAGCCAATGCT
GTGGAATCCTTCAGGGACCCCCAAGAGGTACAGCCTGGAGCTGGGCAAGGCCATTAAACAAAAGCTCTGGGAGGCTCTTTGCAGTCAGGG
TGCCATCTCTGAAGGTGCTCAGAGGGACCGGTTCCCTGGCAGGAAGCAGCCAGGTGTCCACGAGGAGCCTGTACTCAAGAAATGGCCCAA

>16418_16418_4_CHEK2-C22orf31_CHEK2_chr22_29130391_ENST00000404276_C22orf31_chr22_29456831_ENST00000216071_length(amino acids)=321AA_BP=25
MRTKNLRTKNLRSLPLPPGLDYGPFRMDLPILHPINVRRDPSIPIYGLRQSILLNTRLQDCYVDSPALTNIWMARTCAKQNINAPAPATT
SSWEVVRNPLIASSFSLVKLVLRRQLKNKCCPPPCKFGEGKLSKRLKHKDDSVMKATQQARKRNFISSKSKQPAGHRRPAGGIRESKESS
KEKKLTVRQDLEDRYAEHVAATQALPQDSGTAAWKGRVLLPETQKRQQLSEDTLTIHGLPTEGYQALYHAVVEPMLWNPSGTPKRYSLEL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CHEK2-C22orf31


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHEK2-C22orf31


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHEK2-C22orf31


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCHEK2C0009405Hereditary Nonpolyposis Colorectal Neoplasms12CLINGEN
HgeneCHEK2C1112155Hereditary non-polyposis colorectal cancer syndrome12CLINGEN
HgeneCHEK2C1333990Hereditary Nonpolyposis Colorectal Cancer12CLINGEN
HgeneCHEK2C1333991Hereditary Non-Polyposis Colon Cancer Type 212CLINGEN
HgeneCHEK2C2936783Colorectal cancer, hereditary nonpolyposis, type 112CLINGEN
HgeneCHEK2C0346153Breast Cancer, Familial9CLINGEN
HgeneCHEK2C0006142Malignant neoplasm of breast7CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneCHEK2C0678222Breast Carcinoma4CGI;CTD_human
HgeneCHEK2C1257931Mammary Neoplasms, Human4CTD_human
HgeneCHEK2C1458155Mammary Neoplasms4CTD_human
HgeneCHEK2C4704874Mammary Carcinoma, Human4CTD_human
HgeneCHEK2C0085390Li-Fraumeni Syndrome3CTD_human;ORPHANET
HgeneCHEK2C1836482Li-Fraumeni Syndrome 22CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneCHEK2C0009402Colorectal Carcinoma1CTD_human;GENOMICS_ENGLAND
HgeneCHEK2C0009404Colorectal Neoplasms1CTD_human
HgeneCHEK2C0024121Lung Neoplasms1CTD_human
HgeneCHEK2C0024302Reticulosarcoma1CTD_human
HgeneCHEK2C0024304Lymphoma, Mixed-Cell1CTD_human
HgeneCHEK2C0024305Lymphoma, Non-Hodgkin1CTD_human
HgeneCHEK2C0024306Lymphoma, Undifferentiated1CTD_human
HgeneCHEK2C0024623Malignant neoplasm of stomach1CTD_human
HgeneCHEK2C0027819Neuroblastoma1CTD_human
HgeneCHEK2C0029463Osteosarcoma1CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneCHEK2C0033578Prostatic Neoplasms1CTD_human
HgeneCHEK2C0038356Stomach Neoplasms1CTD_human
HgeneCHEK2C0079740High Grade Lymphoma (neoplasm)1CTD_human
HgeneCHEK2C0079741Lymphoma, Intermediate-Grade1CTD_human
HgeneCHEK2C0079747Low Grade Lymphoma (neoplasm)1CTD_human
HgeneCHEK2C0079757Diffuse Mixed-Cell Lymphoma1CTD_human
HgeneCHEK2C0079770Lymphoma, Small Noncleaved-Cell1CTD_human
HgeneCHEK2C0206720Squamous Cell Neoplasms1CTD_human
HgeneCHEK2C0235874Disease Exacerbation1CTD_human
HgeneCHEK2C0238033Carcinoma of Male Breast1CTD_human
HgeneCHEK2C0242379Malignant neoplasm of lung1CTD_human
HgeneCHEK2C0242788Breast Neoplasms, Male1CTD_human
HgeneCHEK2C0376358Malignant neoplasm of prostate1CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneCHEK2C0677776Hereditary Breast and Ovarian Cancer Syndrome1ORPHANET
HgeneCHEK2C0751688Malignant Squamous Cell Neoplasm1CTD_human
HgeneCHEK2C1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneCHEK2C2931456Prostate cancer, familial1CTD_human;ORPHANET
HgeneCHEK2C3714542Lymphoma, Diffuse1CTD_human
HgeneCHEK2C4721532Lymphoma, Non-Hodgkin, Familial1CTD_human
HgeneCHEK2C4722327PROSTATE CANCER, HEREDITARY, 11CTD_human