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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AKAP13-SPI1 (FusionGDB2 ID:HG11214TG6688)

Fusion Gene Summary for AKAP13-SPI1

check button Fusion gene summary
Fusion gene informationFusion gene name: AKAP13-SPI1
Fusion gene ID: hg11214tg6688
HgeneTgene
Gene symbol

AKAP13

SPI1

Gene ID

11214

6688

Gene nameA-kinase anchoring protein 13Spi-1 proto-oncogene
SynonymsAKAP-13|AKAP-Lbc|ARHGEF13|BRX|HA-3|Ht31|LBC|PRKA13|PROTO-LB|PROTO-LBC|c-lbc|p47OF|PU.1|SFPI1|SPI-1|SPI-A
Cytomap('AKAP13')('SPI1')

15q25.3

11p11.2

Type of geneprotein-codingprotein-coding
DescriptionA-kinase anchor protein 13A kinase (PRKA) anchor protein 13LBC oncogenebreast cancer nuclear receptor-binding auxiliary proteinguanine nucleotide exchange factor Lbchuman thyroid-anchoring protein 31lymphoid blast crisis oncogenenon-oncogenic Rho Gtranscription factor PU.131 kDa transforming proteinhematopoietic transcription factor PU.1spleen focus forming virus (SFFV) proviral integration oncogene spi1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000361243, ENST00000394518, 
ENST00000394510, ENST00000560302, 
ENST00000560579, 
Fusion gene scores* DoF score37 X 24 X 13=115445 X 5 X 3=75
# samples 416
** MAII scorelog2(41/11544*10)=-4.81537548498575
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKAP13 [Title/Abstract] AND SPI1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAKAP13(86129054)-SPI1(47380557), # samples:1
Anticipated loss of major functional domain due to fusion event.AKAP13-SPI1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AKAP13-SPI1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AKAP13-SPI1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AKAP13-SPI1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKAP13

GO:0007186

G protein-coupled receptor signaling pathway

11546812

HgeneAKAP13

GO:0035025

positive regulation of Rho protein signal transduction

11546812

TgeneSPI1

GO:0044027

hypermethylation of CpG island

20139074

TgeneSPI1

GO:0045814

negative regulation of gene expression, epigenetic

20139074

TgeneSPI1

GO:0045892

negative regulation of transcription, DNA-templated

20139074

TgeneSPI1

GO:0045893

positive regulation of transcription, DNA-templated

12833137

TgeneSPI1

GO:0061614

pri-miRNA transcription by RNA polymerase II

20972335

TgeneSPI1

GO:0070102

interleukin-6-mediated signaling pathway

24429361


check buttonFusion gene breakpoints across AKAP13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SPI1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-30-1866AKAP13chr15

86129054

+SPI1chr11

47380557

-


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Fusion Gene ORF analysis for AKAP13-SPI1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000361243ENST00000533030AKAP13chr15

86129054

+SPI1chr11

47380557

-
5CDS-intronENST00000361243ENST00000533968AKAP13chr15

86129054

+SPI1chr11

47380557

-
5CDS-intronENST00000394518ENST00000533030AKAP13chr15

86129054

+SPI1chr11

47380557

-
5CDS-intronENST00000394518ENST00000533968AKAP13chr15

86129054

+SPI1chr11

47380557

-
In-frameENST00000361243ENST00000227163AKAP13chr15

86129054

+SPI1chr11

47380557

-
In-frameENST00000361243ENST00000378538AKAP13chr15

86129054

+SPI1chr11

47380557

-
In-frameENST00000394518ENST00000227163AKAP13chr15

86129054

+SPI1chr11

47380557

-
In-frameENST00000394518ENST00000378538AKAP13chr15

86129054

+SPI1chr11

47380557

-
intron-3CDSENST00000394510ENST00000227163AKAP13chr15

86129054

+SPI1chr11

47380557

-
intron-3CDSENST00000394510ENST00000378538AKAP13chr15

86129054

+SPI1chr11

47380557

-
intron-3CDSENST00000560302ENST00000227163AKAP13chr15

86129054

+SPI1chr11

47380557

-
intron-3CDSENST00000560302ENST00000378538AKAP13chr15

86129054

+SPI1chr11

47380557

-
intron-3CDSENST00000560579ENST00000227163AKAP13chr15

86129054

+SPI1chr11

47380557

-
intron-3CDSENST00000560579ENST00000378538AKAP13chr15

86129054

+SPI1chr11

47380557

-
intron-intronENST00000394510ENST00000533030AKAP13chr15

86129054

+SPI1chr11

47380557

-
intron-intronENST00000394510ENST00000533968AKAP13chr15

86129054

+SPI1chr11

47380557

-
intron-intronENST00000560302ENST00000533030AKAP13chr15

86129054

+SPI1chr11

47380557

-
intron-intronENST00000560302ENST00000533968AKAP13chr15

86129054

+SPI1chr11

47380557

-
intron-intronENST00000560579ENST00000533030AKAP13chr15

86129054

+SPI1chr11

47380557

-
intron-intronENST00000560579ENST00000533968AKAP13chr15

86129054

+SPI1chr11

47380557

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000394518AKAP13chr1586129054+ENST00000378538SPI1chr1147380557-510642569547381547
ENST00000394518AKAP13chr1586129054+ENST00000227163SPI1chr1147380557-505342569547381547
ENST00000361243AKAP13chr1586129054+ENST00000378538SPI1chr1147380557-509242428147241547
ENST00000361243AKAP13chr1586129054+ENST00000227163SPI1chr1147380557-503942428147241547

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394518ENST00000378538AKAP13chr1586129054+SPI1chr1147380557-0.0017511670.9982488
ENST00000394518ENST00000227163AKAP13chr1586129054+SPI1chr1147380557-0.0018997210.99810034
ENST00000361243ENST00000378538AKAP13chr1586129054+SPI1chr1147380557-0.0017166150.9982834
ENST00000361243ENST00000227163AKAP13chr1586129054+SPI1chr1147380557-0.0018677070.9981323

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Fusion Genomic Features for AKAP13-SPI1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for AKAP13-SPI1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:86129054/chr11:47380557)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSPI1chr15:86129054chr11:47380557ENST0000022716325170_253111272.0DNA bindingETS
TgeneSPI1chr15:86129054chr11:47380557ENST0000037853825170_253110271.0DNA bindingETS

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKAP13chr15:86129054chr11:47380557ENST00000361243+8371758_179013872818.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP13chr15:86129054chr11:47380557ENST00000361243+8372345_238113872818.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP13chr15:86129054chr11:47380557ENST00000361243+8372568_268313872818.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP13chr15:86129054chr11:47380557ENST00000394518+8371758_179013872814.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP13chr15:86129054chr11:47380557ENST00000394518+8372345_238113872814.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP13chr15:86129054chr11:47380557ENST00000394518+8372568_268313872814.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP13chr15:86129054chr11:47380557ENST00000560302+141758_17900180.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP13chr15:86129054chr11:47380557ENST00000560302+142345_23810180.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP13chr15:86129054chr11:47380557ENST00000560302+142568_26830180.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP13chr15:86129054chr11:47380557ENST00000361243+8371471_147413872818.0Compositional biasNote=Poly-Ser
HgeneAKAP13chr15:86129054chr11:47380557ENST00000361243+8371534_153713872818.0Compositional biasNote=Poly-Glu
HgeneAKAP13chr15:86129054chr11:47380557ENST00000361243+8372778_279013872818.0Compositional biasNote=Poly-Lys
HgeneAKAP13chr15:86129054chr11:47380557ENST00000394518+8371471_147413872814.0Compositional biasNote=Poly-Ser
HgeneAKAP13chr15:86129054chr11:47380557ENST00000394518+8371534_153713872814.0Compositional biasNote=Poly-Glu
HgeneAKAP13chr15:86129054chr11:47380557ENST00000394518+8372778_279013872814.0Compositional biasNote=Poly-Lys
HgeneAKAP13chr15:86129054chr11:47380557ENST00000560302+141471_14740180.0Compositional biasNote=Poly-Ser
HgeneAKAP13chr15:86129054chr11:47380557ENST00000560302+141534_15370180.0Compositional biasNote=Poly-Glu
HgeneAKAP13chr15:86129054chr11:47380557ENST00000560302+142778_27900180.0Compositional biasNote=Poly-Lys
HgeneAKAP13chr15:86129054chr11:47380557ENST00000361243+8371994_219113872818.0DomainDH
HgeneAKAP13chr15:86129054chr11:47380557ENST00000361243+8372231_233313872818.0DomainPH
HgeneAKAP13chr15:86129054chr11:47380557ENST00000394518+8371994_219113872814.0DomainDH
HgeneAKAP13chr15:86129054chr11:47380557ENST00000394518+8372231_233313872814.0DomainPH
HgeneAKAP13chr15:86129054chr11:47380557ENST00000560302+141994_21910180.0DomainDH
HgeneAKAP13chr15:86129054chr11:47380557ENST00000560302+142231_23330180.0DomainPH
HgeneAKAP13chr15:86129054chr11:47380557ENST00000361243+8371791_183813872818.0Zinc fingerPhorbol-ester/DAG-type
HgeneAKAP13chr15:86129054chr11:47380557ENST00000394518+8371791_183813872814.0Zinc fingerPhorbol-ester/DAG-type
HgeneAKAP13chr15:86129054chr11:47380557ENST00000560302+141791_18380180.0Zinc fingerPhorbol-ester/DAG-type


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Fusion Gene Sequence for AKAP13-SPI1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3320_3320_1_AKAP13-SPI1_AKAP13_chr15_86129054_ENST00000361243_SPI1_chr11_47380557_ENST00000227163_length(transcript)=5039nt_BP=4242nt
TGTCTTTCTCCGCGGCGAAGGTGAAGAGTTGTCCCAGCTCGGCCCGCGGGGGAGCCCCGGGAGCCGCACGTGTCCTGGGTCATGAAACTT
AATCCACAGCAAGCTCCCTTATATGGTGATTGTGTTGTTACAGTGCTGCTTGCTGAAGAGGACAAAGCTGAAGATGATGTAGTGTTTTAC
TTGGTATTTTTGGGTTCCACCCTCCGTCACTGTACAAGTACTCGGAAGGTCAGTTCTGATACATTGGAGACCATTGCTCCTGGTCATGAT
TGTTGTGAAACAGTGAAGGTGCAGCTCTGTGCTTCCAAAGAGGGCCTTCCCGTGTTTGTGGTGGCTGAAGAAGACTTTCATTTCGTCCAG
GATGAAGCGTATGATGCAGCTCAATTCCTAGCAACCAGTGCTGGAAATCAGCAGGCTTTGAACTTTACCCGTTTTCTTGACCAGTCAGGA
CCCCCATCTGGGGATGTGAATTCCCTTGATAAGAAGTTGGTGCTGGCATTCAGGCACCTGAAGCTGCCCACGGAGTGGAATGTATTGGGG
ACAGATCAGAGTTTGCATGATGCTGGCCCGCGAGAGACATTGATGCATTTTGCTGTGCGGCTGGGACTGCTGAGGTTGACGTGGTTCCTG
TTGCAGAAGCCAGGTGGCCGCGGAGCTCTCAGTATCCACAACCAGGAAGGGGCGACGCCTGTGAGCTTGGCCTTGGAGCGAGGCTATCAC
AAGCTGCACCAGCTTCTAACCGAGGAGAATGCTGGAGAACCAGACTCCTGGAGCAGTTTATCCTATGAAATACCGTATGGAGACTGTTCT
GTGAGGCATCATCGAGAGTTGGACATCTATACATTAACCTCTGAGTCTGATTCACATCATGAACACCCATTTCCTGGAGACGGTTGCACT
GGACCAATTTTTAAACTTATGAACATCCAACAGCAACTAATGAAAACAAACCTCAAGCAGATGGACAGTCTTATGCCCTTAATGATGACA
GCACAGGATCCTTCCAGTGCCCCAGAGACAGATGGCCAGTTTCTTCCCTGTGCACCGGAGCCCACGGACCCTCAGCGACTTTCTTCTTCT
GAAGAGACTGAGAGCACTCAGTGCTGCCCAGGGAGCCCTGTTGCACAGACTGAAAGTCCCTGTGATTTGTCAAGCATAGTTGAGGAGGAG
AATACAGACCGTTCCTGTAGGAAGAAAAATAAAGGCGTGGAAAGAAAAGGGGAAGAGGTGGAGCCAGCACCTATTGTGGACTCTGGAACT
GTATCTGATCAAGACAGCTGCCTTCAGAGCTTGCCTGATTGTGGAGTAAAGGGCACGGAAGGCCTTTCGTCCTGTGGAAACAGAAATGAA
GAAACTGGAACAAAATCTTCTGGAATGCCCACAGACCAGGAGTCCCTGAGCAGTGGAGATGCTGTGCTTCAGAGAGACTTGGTCATGGAG
CCAGGCACAGCCCAGTATTCCTCTGGAGGTGAACTGGGAGGCATTTCAACAACAAATGTCAGTACCCCAGACACTGCAGGGGAAATGGAA
CATGGGCTCATGAACCCAGATGCCACTGTTTGGAAGAATGTGCTTCAGGGAGGGGAAAGTACAAAGGAAAGATTTGAGAACTCTAATATT
GGCACAGCTGGAGCCTCTGACGTGCACGTCACAAGTAAGCCTGTGGATAAAATCAGTGTTCCAAACTGTGCCCCTGCTGCCAGTTCCCTG
GATGGTAACAAACCTGCTGAGTCTTCACTTGCATTTAGTAATGAAGAAACCTCCACTGAAAAAACAGCAGAAACGGAAACTTCACGAAGT
CGTGAGGAGAGTGCTGATGCTCCAGTAGATCAGAATTCTGTGGTGATTCCAGCTGCTGCAAAAGACAAGATTTCAGATGGATTAGAACCT
TATACTCTCTTAGCAGCAGGCATAGGTGAGGCAATGTCACCCTCAGATTTAGCCCTTCTTGGGCTGGAAGAAGATGTAATGCCACACCAG
AACTCAGAAACAAATTCATCTCATGCTCAAAGCCAAAAGGGCAAATCCTCACCCATTTGTTCTACAACTGGAGACGATAAACTTTGTGCA
GACTCTGCATGTCAACAGAACACAGTGACTTCTAGTGGCGATTTGGTTGCAAAACTGTGTGATAACATAGTTAGCGAGTCCGAAAGCACC
ACAGCAAGGCAACCCAGCTCACAAGATCCACCCGATGCCTCCCACTGTGAAGACCCACAGGCTCATACAGTCACCTCTGACCCTGTAAGG
GATACCCAGGAACGTGCGGATTTTTGTCCTTTCAAAGTGGTGGATAACAAAGGCCAACGAAAAGATGTGAAACTAGATAAACCTTTAACA
AATATGCTTGAGGTGGTTTCACATCCACATCCAGTTGTCCCTAAAATGGAGAAAGAACTGGTGCCAGACCAGGCAGTAATATCAGACAGT
ACTTTCTCTCTGGCAAACAGTCCAGGCAGTGAATCAGTAACCAAGGATGACGCACTTTCTTTTGTCCCCTCCCAGAAAGAAAAGGGAACA
GCAACTCCTGAACTACATACAGCTACAGATTATAGAGATGGCCCAGATGGAAATTCGAATGAGCCTGATACGCGGCCACTAGAAGACAGG
GCAGTAGGCCTGTCCACATCCTCCACTGCTGCAGAGCTTCAGCACGGGATGGGGAATACCAGTCTCACAGGACTTGGTGGAGAGCATGAG
GGTCCCGCCCCTCCAGCAATCCCAGAAGCTCTGAATATCAAGGGGAACACTGACTCTTCCCTGCAAAGTGTGGGTAAGGCCACTTTGGCT
TTAGATTCAGTTTTGACTGAAGAAGGAAAACTTCTGGTGGTTTCAGAAAGCTCTGCAGCTCAGGAACAAGATAAGGATAAAGCGGTGACC
TGTTCCTCTATTAAGGAAAATGCTCTCTCTTCAGGAACTTTGCAGGAAGAGCAGAGAACACCACCTCCTGGACAAGATACTCAACAATTT
CATGAAAAATCAATCTCAGCTGACTGTGCCAAGGACAAAGCACTTCAGCTAAGTAATTCACCGGGTGCATCCTCTGCCTTTCTTAAGGCA
GAAACTGAACATAACAAGGAAGTGGCCCCACAAGTCTCACTGCTGACTCAAGGTGGGGCTGCCCAGAGCCTGGTGCCACCAGGAGCAAGT
CTGGCCACAGAGTCAAGGCAGGAAGCCTTGGGGGCAGAGCACAACAGCTCCGCTCTGTTGCCATGTCTGTTGCCAGATGGGTCTGATGGG
TCCGATGCTCTTAACTGCAGTCAGCCTTCTCCTCTGGATGTTGGAGTGAAGAACACTCAATCCCAGGGAAAAACTAGTGCCTGTGAGGTG
AGTGGAGATGTGACGGTGGATGTTACAGGGGTTAATGCTCTACAAGGTATGGCTGAGCCCAGAAGAGAGAATATATCACACAACACCCAA
GACATCCTGATTCCAAACGTCTTGTTGAGCCAAGAGAAGAATGCCGTTCTAGGTTTGCCAGTGGCTCTACAGGACAAAGCTGTGACTGAC
CCACAGGGAGTTGGAACCCCAGAGATGATACCTCTTGATTGGGAGAAAGGGAAGCTGGAGGGAGCAGACCACAGCTGTACCATGGGTGAC
GCTGAGGAAGCCCAAATAGACGATGAAGCACATCCTGTCCTACTGCAGCCTGTTGCCAAGGAGCTCCCCACAGACATGGAGCTCTCAGCC
CATGATGATGGGGCCCCAGCTGGTGTGAGGGAAGTCATGCGAGCCCCGCCTTCAGGCAGGGAAAGGAGCACTCCCTCTCTACCTTGCATG
GTCTCTGCCCAGGACGCACCTCTGCCTAAGGGGGCAGACTTGATAGAGGAGGCTGCCAGCCGTATAGTGGATGCTGTCATCGAACAAGTC
AAGGCCGCTGGAGCACTGCTTACTGAGGGGGAGGCCTGTCACATGTCACTGTCCAGCCCTGAGTTGGGTCCTCTCACTAAAGGACTAGAG
AGTGCTTTTACAGAAAAAGTGAGTACTTTCCCACCTGGGGAGAGCCTACCAATGGGCAGTACTCCTGAGGAAGCCACGGGGAGCCTTGCA
GGATGTTTTGCTGGAAGGGAGGAGCCAGAGAAGATCATTTTACCTGTCCAGGGGCCTGAGCCAGCAGCAGAAATGCCAGACGTGAAAGCT
GAAGATGAAGTGGATTTTAGAGCAAGTTCAATTTCTGAAGAAGTGGCTGTAGGGAGCATAGCTGCTACACTGAAGATGAAGCAAGGCCCA
ATGACCCAGGCGGTCTCCTACCTGCCCCGGATGTGCCTCCAGTACCCATCCCTGTCCCCAGCCCAGCCCAGCTCAGATGAGGAGGAGGGC
GAGCGGCAGAGCCCCCCACTGGAGGTGTCTGACGGCGAGGCGGATGGCCTGGAGCCCGGGCCTGGGCTCCTGCCTGGGGAGACAGGCAGC
AAGAAGAAGATCCGCCTGTACCAGTTCCTGTTGGACCTGCTCCGCAGCGGCGACATGAAGGACAGCATCTGGTGGGTGGACAAGGACAAG
GGCACCTTCCAGTTCTCGTCCAAGCACAAGGAGGCGCTGGCGCACCGCTGGGGCATCCAGAAGGGCAACCGCAAGAAGATGACCTACCAG
AAGATGGCGCGCGCGCTGCGCAACTACGGCAAGACGGGCGAGGTCAAGAAGGTGAAGAAGAAGCTCACCTACCAGTTCAGCGGCGAAGTG
CTGGGCCGCGGGGGCCTGGCCGAGCGGCGCCACCCGCCCCACTGAGCCCGCAGCCCCCGCCGGGCCCCGCCAGGCCTCCCCGCTGGCCAT
AGCATTAAGCCCTCGCCCGGCCCGGACACAGGGAGGACGCTCCCGGGGCCCAGAGGCAGGACTGTGGCGGGCCGGGCCTCGCCTCACCCG
CCCCCTCCCCCCACTCCAGGCCCCCTCCACATCCCGCTTCGCCTCCCTCCAGGACTCCACCCCGGCTCCCGGACGCCAGCTGGGCGTCAG

>3320_3320_1_AKAP13-SPI1_AKAP13_chr15_86129054_ENST00000361243_SPI1_chr11_47380557_ENST00000227163_length(amino acids)=1547AA_BP=1387
MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAPGHDCCETVKVQLCASKEGLPVFVVAEEDFH
FVQDEAYDAAQFLATSAGNQQALNFTRFLDQSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT
WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYGDCSVRHHRELDIYTLTSESDSHHEHPFPGD
GCTGPIFKLMNIQQQLMKTNLKQMDSLMPLMMTAQDPSSAPETDGQFLPCAPEPTDPQRLSSSEETESTQCCPGSPVAQTESPCDLSSIV
EEENTDRSCRKKNKGVERKGEEVEPAPIVDSGTVSDQDSCLQSLPDCGVKGTEGLSSCGNRNEETGTKSSGMPTDQESLSSGDAVLQRDL
VMEPGTAQYSSGGELGGISTTNVSTPDTAGEMEHGLMNPDATVWKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPNCAPAA
SSLDGNKPAESSLAFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKDKISDGLEPYTLLAAGIGEAMSPSDLALLGLEEDVM
PHQNSETNSSHAQSQKGKSSPICSTTGDDKLCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAHTVTSD
PVRDTQERADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQAVISDSTFSLANSPGSESVTKDDALSFVPSQKE
KGTATPELHTATDYRDGPDGNSNEPDTRPLEDRAVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQSVGKA
TLALDSVLTEEGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTPPPGQDTQQFHEKSISADCAKDKALQLSNSPGASSAF
LKAETEHNKEVAPQVSLLTQGGAAQSLVPPGASLATESRQEALGAEHNSSALLPCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGKTSA
CEVSGDVTVDVTGVNALQGMAEPRRENISHNTQDILIPNVLLSQEKNAVLGLPVALQDKAVTDPQGVGTPEMIPLDWEKGKLEGADHSCT
MGDAEEAQIDDEAHPVLLQPVAKELPTDMELSAHDDGAPAGVREVMRAPPSGRERSTPSLPCMVSAQDAPLPKGADLIEEAASRIVDAVI
EQVKAAGALLTEGEACHMSLSSPELGPLTKGLESAFTEKVSTFPPGESLPMGSTPEEATGSLAGCFAGREEPEKIILPVQGPEPAAEMPD
VKAEDEVDFRASSISEEVAVGSIAATLKMKQGPMTQAVSYLPRMCLQYPSLSPAQPSSDEEEGERQSPPLEVSDGEADGLEPGPGLLPGE
TGSKKKIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGEVKKVKKKLTYQFS

--------------------------------------------------------------
>3320_3320_2_AKAP13-SPI1_AKAP13_chr15_86129054_ENST00000361243_SPI1_chr11_47380557_ENST00000378538_length(transcript)=5092nt_BP=4242nt
TGTCTTTCTCCGCGGCGAAGGTGAAGAGTTGTCCCAGCTCGGCCCGCGGGGGAGCCCCGGGAGCCGCACGTGTCCTGGGTCATGAAACTT
AATCCACAGCAAGCTCCCTTATATGGTGATTGTGTTGTTACAGTGCTGCTTGCTGAAGAGGACAAAGCTGAAGATGATGTAGTGTTTTAC
TTGGTATTTTTGGGTTCCACCCTCCGTCACTGTACAAGTACTCGGAAGGTCAGTTCTGATACATTGGAGACCATTGCTCCTGGTCATGAT
TGTTGTGAAACAGTGAAGGTGCAGCTCTGTGCTTCCAAAGAGGGCCTTCCCGTGTTTGTGGTGGCTGAAGAAGACTTTCATTTCGTCCAG
GATGAAGCGTATGATGCAGCTCAATTCCTAGCAACCAGTGCTGGAAATCAGCAGGCTTTGAACTTTACCCGTTTTCTTGACCAGTCAGGA
CCCCCATCTGGGGATGTGAATTCCCTTGATAAGAAGTTGGTGCTGGCATTCAGGCACCTGAAGCTGCCCACGGAGTGGAATGTATTGGGG
ACAGATCAGAGTTTGCATGATGCTGGCCCGCGAGAGACATTGATGCATTTTGCTGTGCGGCTGGGACTGCTGAGGTTGACGTGGTTCCTG
TTGCAGAAGCCAGGTGGCCGCGGAGCTCTCAGTATCCACAACCAGGAAGGGGCGACGCCTGTGAGCTTGGCCTTGGAGCGAGGCTATCAC
AAGCTGCACCAGCTTCTAACCGAGGAGAATGCTGGAGAACCAGACTCCTGGAGCAGTTTATCCTATGAAATACCGTATGGAGACTGTTCT
GTGAGGCATCATCGAGAGTTGGACATCTATACATTAACCTCTGAGTCTGATTCACATCATGAACACCCATTTCCTGGAGACGGTTGCACT
GGACCAATTTTTAAACTTATGAACATCCAACAGCAACTAATGAAAACAAACCTCAAGCAGATGGACAGTCTTATGCCCTTAATGATGACA
GCACAGGATCCTTCCAGTGCCCCAGAGACAGATGGCCAGTTTCTTCCCTGTGCACCGGAGCCCACGGACCCTCAGCGACTTTCTTCTTCT
GAAGAGACTGAGAGCACTCAGTGCTGCCCAGGGAGCCCTGTTGCACAGACTGAAAGTCCCTGTGATTTGTCAAGCATAGTTGAGGAGGAG
AATACAGACCGTTCCTGTAGGAAGAAAAATAAAGGCGTGGAAAGAAAAGGGGAAGAGGTGGAGCCAGCACCTATTGTGGACTCTGGAACT
GTATCTGATCAAGACAGCTGCCTTCAGAGCTTGCCTGATTGTGGAGTAAAGGGCACGGAAGGCCTTTCGTCCTGTGGAAACAGAAATGAA
GAAACTGGAACAAAATCTTCTGGAATGCCCACAGACCAGGAGTCCCTGAGCAGTGGAGATGCTGTGCTTCAGAGAGACTTGGTCATGGAG
CCAGGCACAGCCCAGTATTCCTCTGGAGGTGAACTGGGAGGCATTTCAACAACAAATGTCAGTACCCCAGACACTGCAGGGGAAATGGAA
CATGGGCTCATGAACCCAGATGCCACTGTTTGGAAGAATGTGCTTCAGGGAGGGGAAAGTACAAAGGAAAGATTTGAGAACTCTAATATT
GGCACAGCTGGAGCCTCTGACGTGCACGTCACAAGTAAGCCTGTGGATAAAATCAGTGTTCCAAACTGTGCCCCTGCTGCCAGTTCCCTG
GATGGTAACAAACCTGCTGAGTCTTCACTTGCATTTAGTAATGAAGAAACCTCCACTGAAAAAACAGCAGAAACGGAAACTTCACGAAGT
CGTGAGGAGAGTGCTGATGCTCCAGTAGATCAGAATTCTGTGGTGATTCCAGCTGCTGCAAAAGACAAGATTTCAGATGGATTAGAACCT
TATACTCTCTTAGCAGCAGGCATAGGTGAGGCAATGTCACCCTCAGATTTAGCCCTTCTTGGGCTGGAAGAAGATGTAATGCCACACCAG
AACTCAGAAACAAATTCATCTCATGCTCAAAGCCAAAAGGGCAAATCCTCACCCATTTGTTCTACAACTGGAGACGATAAACTTTGTGCA
GACTCTGCATGTCAACAGAACACAGTGACTTCTAGTGGCGATTTGGTTGCAAAACTGTGTGATAACATAGTTAGCGAGTCCGAAAGCACC
ACAGCAAGGCAACCCAGCTCACAAGATCCACCCGATGCCTCCCACTGTGAAGACCCACAGGCTCATACAGTCACCTCTGACCCTGTAAGG
GATACCCAGGAACGTGCGGATTTTTGTCCTTTCAAAGTGGTGGATAACAAAGGCCAACGAAAAGATGTGAAACTAGATAAACCTTTAACA
AATATGCTTGAGGTGGTTTCACATCCACATCCAGTTGTCCCTAAAATGGAGAAAGAACTGGTGCCAGACCAGGCAGTAATATCAGACAGT
ACTTTCTCTCTGGCAAACAGTCCAGGCAGTGAATCAGTAACCAAGGATGACGCACTTTCTTTTGTCCCCTCCCAGAAAGAAAAGGGAACA
GCAACTCCTGAACTACATACAGCTACAGATTATAGAGATGGCCCAGATGGAAATTCGAATGAGCCTGATACGCGGCCACTAGAAGACAGG
GCAGTAGGCCTGTCCACATCCTCCACTGCTGCAGAGCTTCAGCACGGGATGGGGAATACCAGTCTCACAGGACTTGGTGGAGAGCATGAG
GGTCCCGCCCCTCCAGCAATCCCAGAAGCTCTGAATATCAAGGGGAACACTGACTCTTCCCTGCAAAGTGTGGGTAAGGCCACTTTGGCT
TTAGATTCAGTTTTGACTGAAGAAGGAAAACTTCTGGTGGTTTCAGAAAGCTCTGCAGCTCAGGAACAAGATAAGGATAAAGCGGTGACC
TGTTCCTCTATTAAGGAAAATGCTCTCTCTTCAGGAACTTTGCAGGAAGAGCAGAGAACACCACCTCCTGGACAAGATACTCAACAATTT
CATGAAAAATCAATCTCAGCTGACTGTGCCAAGGACAAAGCACTTCAGCTAAGTAATTCACCGGGTGCATCCTCTGCCTTTCTTAAGGCA
GAAACTGAACATAACAAGGAAGTGGCCCCACAAGTCTCACTGCTGACTCAAGGTGGGGCTGCCCAGAGCCTGGTGCCACCAGGAGCAAGT
CTGGCCACAGAGTCAAGGCAGGAAGCCTTGGGGGCAGAGCACAACAGCTCCGCTCTGTTGCCATGTCTGTTGCCAGATGGGTCTGATGGG
TCCGATGCTCTTAACTGCAGTCAGCCTTCTCCTCTGGATGTTGGAGTGAAGAACACTCAATCCCAGGGAAAAACTAGTGCCTGTGAGGTG
AGTGGAGATGTGACGGTGGATGTTACAGGGGTTAATGCTCTACAAGGTATGGCTGAGCCCAGAAGAGAGAATATATCACACAACACCCAA
GACATCCTGATTCCAAACGTCTTGTTGAGCCAAGAGAAGAATGCCGTTCTAGGTTTGCCAGTGGCTCTACAGGACAAAGCTGTGACTGAC
CCACAGGGAGTTGGAACCCCAGAGATGATACCTCTTGATTGGGAGAAAGGGAAGCTGGAGGGAGCAGACCACAGCTGTACCATGGGTGAC
GCTGAGGAAGCCCAAATAGACGATGAAGCACATCCTGTCCTACTGCAGCCTGTTGCCAAGGAGCTCCCCACAGACATGGAGCTCTCAGCC
CATGATGATGGGGCCCCAGCTGGTGTGAGGGAAGTCATGCGAGCCCCGCCTTCAGGCAGGGAAAGGAGCACTCCCTCTCTACCTTGCATG
GTCTCTGCCCAGGACGCACCTCTGCCTAAGGGGGCAGACTTGATAGAGGAGGCTGCCAGCCGTATAGTGGATGCTGTCATCGAACAAGTC
AAGGCCGCTGGAGCACTGCTTACTGAGGGGGAGGCCTGTCACATGTCACTGTCCAGCCCTGAGTTGGGTCCTCTCACTAAAGGACTAGAG
AGTGCTTTTACAGAAAAAGTGAGTACTTTCCCACCTGGGGAGAGCCTACCAATGGGCAGTACTCCTGAGGAAGCCACGGGGAGCCTTGCA
GGATGTTTTGCTGGAAGGGAGGAGCCAGAGAAGATCATTTTACCTGTCCAGGGGCCTGAGCCAGCAGCAGAAATGCCAGACGTGAAAGCT
GAAGATGAAGTGGATTTTAGAGCAAGTTCAATTTCTGAAGAAGTGGCTGTAGGGAGCATAGCTGCTACACTGAAGATGAAGCAAGGCCCA
ATGACCCAGGCGGTCTCCTACCTGCCCCGGATGTGCCTCCAGTACCCATCCCTGTCCCCAGCCCAGCCCAGCTCAGATGAGGAGGAGGGC
GAGCGGCAGAGCCCCCCACTGGAGGTGTCTGACGGCGAGGCGGATGGCCTGGAGCCCGGGCCTGGGCTCCTGCCTGGGGAGACAGGCAGC
AAGAAGAAGATCCGCCTGTACCAGTTCCTGTTGGACCTGCTCCGCAGCGGCGACATGAAGGACAGCATCTGGTGGGTGGACAAGGACAAG
GGCACCTTCCAGTTCTCGTCCAAGCACAAGGAGGCGCTGGCGCACCGCTGGGGCATCCAGAAGGGCAACCGCAAGAAGATGACCTACCAG
AAGATGGCGCGCGCGCTGCGCAACTACGGCAAGACGGGCGAGGTCAAGAAGGTGAAGAAGAAGCTCACCTACCAGTTCAGCGGCGAAGTG
CTGGGCCGCGGGGGCCTGGCCGAGCGGCGCCACCCGCCCCACTGAGCCCGCAGCCCCCGCCGGGCCCCGCCAGGCCTCCCCGCTGGCCAT
AGCATTAAGCCCTCGCCCGGCCCGGACACAGGGAGGACGCTCCCGGGGCCCAGAGGCAGGACTGTGGCGGGCCGGGCCTCGCCTCACCCG
CCCCCTCCCCCCACTCCAGGCCCCCTCCACATCCCGCTTCGCCTCCCTCCAGGACTCCACCCCGGCTCCCGGACGCCAGCTGGGCGTCAG
ACCCCACCGGGGCAACCTTGCAGAGGACGACCCGGGGTACTGCCTTGGGAGTCTCAAGTCCGTATGTAAATCAGATCTCCCCTCTCACCC

>3320_3320_2_AKAP13-SPI1_AKAP13_chr15_86129054_ENST00000361243_SPI1_chr11_47380557_ENST00000378538_length(amino acids)=1547AA_BP=1387
MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAPGHDCCETVKVQLCASKEGLPVFVVAEEDFH
FVQDEAYDAAQFLATSAGNQQALNFTRFLDQSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT
WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYGDCSVRHHRELDIYTLTSESDSHHEHPFPGD
GCTGPIFKLMNIQQQLMKTNLKQMDSLMPLMMTAQDPSSAPETDGQFLPCAPEPTDPQRLSSSEETESTQCCPGSPVAQTESPCDLSSIV
EEENTDRSCRKKNKGVERKGEEVEPAPIVDSGTVSDQDSCLQSLPDCGVKGTEGLSSCGNRNEETGTKSSGMPTDQESLSSGDAVLQRDL
VMEPGTAQYSSGGELGGISTTNVSTPDTAGEMEHGLMNPDATVWKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPNCAPAA
SSLDGNKPAESSLAFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKDKISDGLEPYTLLAAGIGEAMSPSDLALLGLEEDVM
PHQNSETNSSHAQSQKGKSSPICSTTGDDKLCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAHTVTSD
PVRDTQERADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQAVISDSTFSLANSPGSESVTKDDALSFVPSQKE
KGTATPELHTATDYRDGPDGNSNEPDTRPLEDRAVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQSVGKA
TLALDSVLTEEGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTPPPGQDTQQFHEKSISADCAKDKALQLSNSPGASSAF
LKAETEHNKEVAPQVSLLTQGGAAQSLVPPGASLATESRQEALGAEHNSSALLPCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGKTSA
CEVSGDVTVDVTGVNALQGMAEPRRENISHNTQDILIPNVLLSQEKNAVLGLPVALQDKAVTDPQGVGTPEMIPLDWEKGKLEGADHSCT
MGDAEEAQIDDEAHPVLLQPVAKELPTDMELSAHDDGAPAGVREVMRAPPSGRERSTPSLPCMVSAQDAPLPKGADLIEEAASRIVDAVI
EQVKAAGALLTEGEACHMSLSSPELGPLTKGLESAFTEKVSTFPPGESLPMGSTPEEATGSLAGCFAGREEPEKIILPVQGPEPAAEMPD
VKAEDEVDFRASSISEEVAVGSIAATLKMKQGPMTQAVSYLPRMCLQYPSLSPAQPSSDEEEGERQSPPLEVSDGEADGLEPGPGLLPGE
TGSKKKIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGEVKKVKKKLTYQFS

--------------------------------------------------------------
>3320_3320_3_AKAP13-SPI1_AKAP13_chr15_86129054_ENST00000394518_SPI1_chr11_47380557_ENST00000227163_length(transcript)=5053nt_BP=4256nt
GAGCGGCCGCCTATTGTCTTTCTCCGCGGCGAAGGTGAAGAGTTGTCCCAGCTCGGCCCGCGGGGGAGCCCCGGGAGCCGCACGTGTCCT
GGGTCATGAAACTTAATCCACAGCAAGCTCCCTTATATGGTGATTGTGTTGTTACAGTGCTGCTTGCTGAAGAGGACAAAGCTGAAGATG
ATGTAGTGTTTTACTTGGTATTTTTGGGTTCCACCCTCCGTCACTGTACAAGTACTCGGAAGGTCAGTTCTGATACATTGGAGACCATTG
CTCCTGGTCATGATTGTTGTGAAACAGTGAAGGTGCAGCTCTGTGCTTCCAAAGAGGGCCTTCCCGTGTTTGTGGTGGCTGAAGAAGACT
TTCATTTCGTCCAGGATGAAGCGTATGATGCAGCTCAATTCCTAGCAACCAGTGCTGGAAATCAGCAGGCTTTGAACTTTACCCGTTTTC
TTGACCAGTCAGGACCCCCATCTGGGGATGTGAATTCCCTTGATAAGAAGTTGGTGCTGGCATTCAGGCACCTGAAGCTGCCCACGGAGT
GGAATGTATTGGGGACAGATCAGAGTTTGCATGATGCTGGCCCGCGAGAGACATTGATGCATTTTGCTGTGCGGCTGGGACTGCTGAGGT
TGACGTGGTTCCTGTTGCAGAAGCCAGGTGGCCGCGGAGCTCTCAGTATCCACAACCAGGAAGGGGCGACGCCTGTGAGCTTGGCCTTGG
AGCGAGGCTATCACAAGCTGCACCAGCTTCTAACCGAGGAGAATGCTGGAGAACCAGACTCCTGGAGCAGTTTATCCTATGAAATACCGT
ATGGAGACTGTTCTGTGAGGCATCATCGAGAGTTGGACATCTATACATTAACCTCTGAGTCTGATTCACATCATGAACACCCATTTCCTG
GAGACGGTTGCACTGGACCAATTTTTAAACTTATGAACATCCAACAGCAACTAATGAAAACAAACCTCAAGCAGATGGACAGTCTTATGC
CCTTAATGATGACAGCACAGGATCCTTCCAGTGCCCCAGAGACAGATGGCCAGTTTCTTCCCTGTGCACCGGAGCCCACGGACCCTCAGC
GACTTTCTTCTTCTGAAGAGACTGAGAGCACTCAGTGCTGCCCAGGGAGCCCTGTTGCACAGACTGAAAGTCCCTGTGATTTGTCAAGCA
TAGTTGAGGAGGAGAATACAGACCGTTCCTGTAGGAAGAAAAATAAAGGCGTGGAAAGAAAAGGGGAAGAGGTGGAGCCAGCACCTATTG
TGGACTCTGGAACTGTATCTGATCAAGACAGCTGCCTTCAGAGCTTGCCTGATTGTGGAGTAAAGGGCACGGAAGGCCTTTCGTCCTGTG
GAAACAGAAATGAAGAAACTGGAACAAAATCTTCTGGAATGCCCACAGACCAGGAGTCCCTGAGCAGTGGAGATGCTGTGCTTCAGAGAG
ACTTGGTCATGGAGCCAGGCACAGCCCAGTATTCCTCTGGAGGTGAACTGGGAGGCATTTCAACAACAAATGTCAGTACCCCAGACACTG
CAGGGGAAATGGAACATGGGCTCATGAACCCAGATGCCACTGTTTGGAAGAATGTGCTTCAGGGAGGGGAAAGTACAAAGGAAAGATTTG
AGAACTCTAATATTGGCACAGCTGGAGCCTCTGACGTGCACGTCACAAGTAAGCCTGTGGATAAAATCAGTGTTCCAAACTGTGCCCCTG
CTGCCAGTTCCCTGGATGGTAACAAACCTGCTGAGTCTTCACTTGCATTTAGTAATGAAGAAACCTCCACTGAAAAAACAGCAGAAACGG
AAACTTCACGAAGTCGTGAGGAGAGTGCTGATGCTCCAGTAGATCAGAATTCTGTGGTGATTCCAGCTGCTGCAAAAGACAAGATTTCAG
ATGGATTAGAACCTTATACTCTCTTAGCAGCAGGCATAGGTGAGGCAATGTCACCCTCAGATTTAGCCCTTCTTGGGCTGGAAGAAGATG
TAATGCCACACCAGAACTCAGAAACAAATTCATCTCATGCTCAAAGCCAAAAGGGCAAATCCTCACCCATTTGTTCTACAACTGGAGACG
ATAAACTTTGTGCAGACTCTGCATGTCAACAGAACACAGTGACTTCTAGTGGCGATTTGGTTGCAAAACTGTGTGATAACATAGTTAGCG
AGTCCGAAAGCACCACAGCAAGGCAACCCAGCTCACAAGATCCACCCGATGCCTCCCACTGTGAAGACCCACAGGCTCATACAGTCACCT
CTGACCCTGTAAGGGATACCCAGGAACGTGCGGATTTTTGTCCTTTCAAAGTGGTGGATAACAAAGGCCAACGAAAAGATGTGAAACTAG
ATAAACCTTTAACAAATATGCTTGAGGTGGTTTCACATCCACATCCAGTTGTCCCTAAAATGGAGAAAGAACTGGTGCCAGACCAGGCAG
TAATATCAGACAGTACTTTCTCTCTGGCAAACAGTCCAGGCAGTGAATCAGTAACCAAGGATGACGCACTTTCTTTTGTCCCCTCCCAGA
AAGAAAAGGGAACAGCAACTCCTGAACTACATACAGCTACAGATTATAGAGATGGCCCAGATGGAAATTCGAATGAGCCTGATACGCGGC
CACTAGAAGACAGGGCAGTAGGCCTGTCCACATCCTCCACTGCTGCAGAGCTTCAGCACGGGATGGGGAATACCAGTCTCACAGGACTTG
GTGGAGAGCATGAGGGTCCCGCCCCTCCAGCAATCCCAGAAGCTCTGAATATCAAGGGGAACACTGACTCTTCCCTGCAAAGTGTGGGTA
AGGCCACTTTGGCTTTAGATTCAGTTTTGACTGAAGAAGGAAAACTTCTGGTGGTTTCAGAAAGCTCTGCAGCTCAGGAACAAGATAAGG
ATAAAGCGGTGACCTGTTCCTCTATTAAGGAAAATGCTCTCTCTTCAGGAACTTTGCAGGAAGAGCAGAGAACACCACCTCCTGGACAAG
ATACTCAACAATTTCATGAAAAATCAATCTCAGCTGACTGTGCCAAGGACAAAGCACTTCAGCTAAGTAATTCACCGGGTGCATCCTCTG
CCTTTCTTAAGGCAGAAACTGAACATAACAAGGAAGTGGCCCCACAAGTCTCACTGCTGACTCAAGGTGGGGCTGCCCAGAGCCTGGTGC
CACCAGGAGCAAGTCTGGCCACAGAGTCAAGGCAGGAAGCCTTGGGGGCAGAGCACAACAGCTCCGCTCTGTTGCCATGTCTGTTGCCAG
ATGGGTCTGATGGGTCCGATGCTCTTAACTGCAGTCAGCCTTCTCCTCTGGATGTTGGAGTGAAGAACACTCAATCCCAGGGAAAAACTA
GTGCCTGTGAGGTGAGTGGAGATGTGACGGTGGATGTTACAGGGGTTAATGCTCTACAAGGTATGGCTGAGCCCAGAAGAGAGAATATAT
CACACAACACCCAAGACATCCTGATTCCAAACGTCTTGTTGAGCCAAGAGAAGAATGCCGTTCTAGGTTTGCCAGTGGCTCTACAGGACA
AAGCTGTGACTGACCCACAGGGAGTTGGAACCCCAGAGATGATACCTCTTGATTGGGAGAAAGGGAAGCTGGAGGGAGCAGACCACAGCT
GTACCATGGGTGACGCTGAGGAAGCCCAAATAGACGATGAAGCACATCCTGTCCTACTGCAGCCTGTTGCCAAGGAGCTCCCCACAGACA
TGGAGCTCTCAGCCCATGATGATGGGGCCCCAGCTGGTGTGAGGGAAGTCATGCGAGCCCCGCCTTCAGGCAGGGAAAGGAGCACTCCCT
CTCTACCTTGCATGGTCTCTGCCCAGGACGCACCTCTGCCTAAGGGGGCAGACTTGATAGAGGAGGCTGCCAGCCGTATAGTGGATGCTG
TCATCGAACAAGTCAAGGCCGCTGGAGCACTGCTTACTGAGGGGGAGGCCTGTCACATGTCACTGTCCAGCCCTGAGTTGGGTCCTCTCA
CTAAAGGACTAGAGAGTGCTTTTACAGAAAAAGTGAGTACTTTCCCACCTGGGGAGAGCCTACCAATGGGCAGTACTCCTGAGGAAGCCA
CGGGGAGCCTTGCAGGATGTTTTGCTGGAAGGGAGGAGCCAGAGAAGATCATTTTACCTGTCCAGGGGCCTGAGCCAGCAGCAGAAATGC
CAGACGTGAAAGCTGAAGATGAAGTGGATTTTAGAGCAAGTTCAATTTCTGAAGAAGTGGCTGTAGGGAGCATAGCTGCTACACTGAAGA
TGAAGCAAGGCCCAATGACCCAGGCGGTCTCCTACCTGCCCCGGATGTGCCTCCAGTACCCATCCCTGTCCCCAGCCCAGCCCAGCTCAG
ATGAGGAGGAGGGCGAGCGGCAGAGCCCCCCACTGGAGGTGTCTGACGGCGAGGCGGATGGCCTGGAGCCCGGGCCTGGGCTCCTGCCTG
GGGAGACAGGCAGCAAGAAGAAGATCCGCCTGTACCAGTTCCTGTTGGACCTGCTCCGCAGCGGCGACATGAAGGACAGCATCTGGTGGG
TGGACAAGGACAAGGGCACCTTCCAGTTCTCGTCCAAGCACAAGGAGGCGCTGGCGCACCGCTGGGGCATCCAGAAGGGCAACCGCAAGA
AGATGACCTACCAGAAGATGGCGCGCGCGCTGCGCAACTACGGCAAGACGGGCGAGGTCAAGAAGGTGAAGAAGAAGCTCACCTACCAGT
TCAGCGGCGAAGTGCTGGGCCGCGGGGGCCTGGCCGAGCGGCGCCACCCGCCCCACTGAGCCCGCAGCCCCCGCCGGGCCCCGCCAGGCC
TCCCCGCTGGCCATAGCATTAAGCCCTCGCCCGGCCCGGACACAGGGAGGACGCTCCCGGGGCCCAGAGGCAGGACTGTGGCGGGCCGGG
CCTCGCCTCACCCGCCCCCTCCCCCCACTCCAGGCCCCCTCCACATCCCGCTTCGCCTCCCTCCAGGACTCCACCCCGGCTCCCGGACGC
CAGCTGGGCGTCAGACCCCACCGGGGCAACCTTGCAGAGGACGACCCGGGGTACTGCCTTGGGAGTCTCAAGTCCGTATGTAAATCAGAT

>3320_3320_3_AKAP13-SPI1_AKAP13_chr15_86129054_ENST00000394518_SPI1_chr11_47380557_ENST00000227163_length(amino acids)=1547AA_BP=1387
MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAPGHDCCETVKVQLCASKEGLPVFVVAEEDFH
FVQDEAYDAAQFLATSAGNQQALNFTRFLDQSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT
WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYGDCSVRHHRELDIYTLTSESDSHHEHPFPGD
GCTGPIFKLMNIQQQLMKTNLKQMDSLMPLMMTAQDPSSAPETDGQFLPCAPEPTDPQRLSSSEETESTQCCPGSPVAQTESPCDLSSIV
EEENTDRSCRKKNKGVERKGEEVEPAPIVDSGTVSDQDSCLQSLPDCGVKGTEGLSSCGNRNEETGTKSSGMPTDQESLSSGDAVLQRDL
VMEPGTAQYSSGGELGGISTTNVSTPDTAGEMEHGLMNPDATVWKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPNCAPAA
SSLDGNKPAESSLAFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKDKISDGLEPYTLLAAGIGEAMSPSDLALLGLEEDVM
PHQNSETNSSHAQSQKGKSSPICSTTGDDKLCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAHTVTSD
PVRDTQERADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQAVISDSTFSLANSPGSESVTKDDALSFVPSQKE
KGTATPELHTATDYRDGPDGNSNEPDTRPLEDRAVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQSVGKA
TLALDSVLTEEGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTPPPGQDTQQFHEKSISADCAKDKALQLSNSPGASSAF
LKAETEHNKEVAPQVSLLTQGGAAQSLVPPGASLATESRQEALGAEHNSSALLPCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGKTSA
CEVSGDVTVDVTGVNALQGMAEPRRENISHNTQDILIPNVLLSQEKNAVLGLPVALQDKAVTDPQGVGTPEMIPLDWEKGKLEGADHSCT
MGDAEEAQIDDEAHPVLLQPVAKELPTDMELSAHDDGAPAGVREVMRAPPSGRERSTPSLPCMVSAQDAPLPKGADLIEEAASRIVDAVI
EQVKAAGALLTEGEACHMSLSSPELGPLTKGLESAFTEKVSTFPPGESLPMGSTPEEATGSLAGCFAGREEPEKIILPVQGPEPAAEMPD
VKAEDEVDFRASSISEEVAVGSIAATLKMKQGPMTQAVSYLPRMCLQYPSLSPAQPSSDEEEGERQSPPLEVSDGEADGLEPGPGLLPGE
TGSKKKIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGEVKKVKKKLTYQFS

--------------------------------------------------------------
>3320_3320_4_AKAP13-SPI1_AKAP13_chr15_86129054_ENST00000394518_SPI1_chr11_47380557_ENST00000378538_length(transcript)=5106nt_BP=4256nt
GAGCGGCCGCCTATTGTCTTTCTCCGCGGCGAAGGTGAAGAGTTGTCCCAGCTCGGCCCGCGGGGGAGCCCCGGGAGCCGCACGTGTCCT
GGGTCATGAAACTTAATCCACAGCAAGCTCCCTTATATGGTGATTGTGTTGTTACAGTGCTGCTTGCTGAAGAGGACAAAGCTGAAGATG
ATGTAGTGTTTTACTTGGTATTTTTGGGTTCCACCCTCCGTCACTGTACAAGTACTCGGAAGGTCAGTTCTGATACATTGGAGACCATTG
CTCCTGGTCATGATTGTTGTGAAACAGTGAAGGTGCAGCTCTGTGCTTCCAAAGAGGGCCTTCCCGTGTTTGTGGTGGCTGAAGAAGACT
TTCATTTCGTCCAGGATGAAGCGTATGATGCAGCTCAATTCCTAGCAACCAGTGCTGGAAATCAGCAGGCTTTGAACTTTACCCGTTTTC
TTGACCAGTCAGGACCCCCATCTGGGGATGTGAATTCCCTTGATAAGAAGTTGGTGCTGGCATTCAGGCACCTGAAGCTGCCCACGGAGT
GGAATGTATTGGGGACAGATCAGAGTTTGCATGATGCTGGCCCGCGAGAGACATTGATGCATTTTGCTGTGCGGCTGGGACTGCTGAGGT
TGACGTGGTTCCTGTTGCAGAAGCCAGGTGGCCGCGGAGCTCTCAGTATCCACAACCAGGAAGGGGCGACGCCTGTGAGCTTGGCCTTGG
AGCGAGGCTATCACAAGCTGCACCAGCTTCTAACCGAGGAGAATGCTGGAGAACCAGACTCCTGGAGCAGTTTATCCTATGAAATACCGT
ATGGAGACTGTTCTGTGAGGCATCATCGAGAGTTGGACATCTATACATTAACCTCTGAGTCTGATTCACATCATGAACACCCATTTCCTG
GAGACGGTTGCACTGGACCAATTTTTAAACTTATGAACATCCAACAGCAACTAATGAAAACAAACCTCAAGCAGATGGACAGTCTTATGC
CCTTAATGATGACAGCACAGGATCCTTCCAGTGCCCCAGAGACAGATGGCCAGTTTCTTCCCTGTGCACCGGAGCCCACGGACCCTCAGC
GACTTTCTTCTTCTGAAGAGACTGAGAGCACTCAGTGCTGCCCAGGGAGCCCTGTTGCACAGACTGAAAGTCCCTGTGATTTGTCAAGCA
TAGTTGAGGAGGAGAATACAGACCGTTCCTGTAGGAAGAAAAATAAAGGCGTGGAAAGAAAAGGGGAAGAGGTGGAGCCAGCACCTATTG
TGGACTCTGGAACTGTATCTGATCAAGACAGCTGCCTTCAGAGCTTGCCTGATTGTGGAGTAAAGGGCACGGAAGGCCTTTCGTCCTGTG
GAAACAGAAATGAAGAAACTGGAACAAAATCTTCTGGAATGCCCACAGACCAGGAGTCCCTGAGCAGTGGAGATGCTGTGCTTCAGAGAG
ACTTGGTCATGGAGCCAGGCACAGCCCAGTATTCCTCTGGAGGTGAACTGGGAGGCATTTCAACAACAAATGTCAGTACCCCAGACACTG
CAGGGGAAATGGAACATGGGCTCATGAACCCAGATGCCACTGTTTGGAAGAATGTGCTTCAGGGAGGGGAAAGTACAAAGGAAAGATTTG
AGAACTCTAATATTGGCACAGCTGGAGCCTCTGACGTGCACGTCACAAGTAAGCCTGTGGATAAAATCAGTGTTCCAAACTGTGCCCCTG
CTGCCAGTTCCCTGGATGGTAACAAACCTGCTGAGTCTTCACTTGCATTTAGTAATGAAGAAACCTCCACTGAAAAAACAGCAGAAACGG
AAACTTCACGAAGTCGTGAGGAGAGTGCTGATGCTCCAGTAGATCAGAATTCTGTGGTGATTCCAGCTGCTGCAAAAGACAAGATTTCAG
ATGGATTAGAACCTTATACTCTCTTAGCAGCAGGCATAGGTGAGGCAATGTCACCCTCAGATTTAGCCCTTCTTGGGCTGGAAGAAGATG
TAATGCCACACCAGAACTCAGAAACAAATTCATCTCATGCTCAAAGCCAAAAGGGCAAATCCTCACCCATTTGTTCTACAACTGGAGACG
ATAAACTTTGTGCAGACTCTGCATGTCAACAGAACACAGTGACTTCTAGTGGCGATTTGGTTGCAAAACTGTGTGATAACATAGTTAGCG
AGTCCGAAAGCACCACAGCAAGGCAACCCAGCTCACAAGATCCACCCGATGCCTCCCACTGTGAAGACCCACAGGCTCATACAGTCACCT
CTGACCCTGTAAGGGATACCCAGGAACGTGCGGATTTTTGTCCTTTCAAAGTGGTGGATAACAAAGGCCAACGAAAAGATGTGAAACTAG
ATAAACCTTTAACAAATATGCTTGAGGTGGTTTCACATCCACATCCAGTTGTCCCTAAAATGGAGAAAGAACTGGTGCCAGACCAGGCAG
TAATATCAGACAGTACTTTCTCTCTGGCAAACAGTCCAGGCAGTGAATCAGTAACCAAGGATGACGCACTTTCTTTTGTCCCCTCCCAGA
AAGAAAAGGGAACAGCAACTCCTGAACTACATACAGCTACAGATTATAGAGATGGCCCAGATGGAAATTCGAATGAGCCTGATACGCGGC
CACTAGAAGACAGGGCAGTAGGCCTGTCCACATCCTCCACTGCTGCAGAGCTTCAGCACGGGATGGGGAATACCAGTCTCACAGGACTTG
GTGGAGAGCATGAGGGTCCCGCCCCTCCAGCAATCCCAGAAGCTCTGAATATCAAGGGGAACACTGACTCTTCCCTGCAAAGTGTGGGTA
AGGCCACTTTGGCTTTAGATTCAGTTTTGACTGAAGAAGGAAAACTTCTGGTGGTTTCAGAAAGCTCTGCAGCTCAGGAACAAGATAAGG
ATAAAGCGGTGACCTGTTCCTCTATTAAGGAAAATGCTCTCTCTTCAGGAACTTTGCAGGAAGAGCAGAGAACACCACCTCCTGGACAAG
ATACTCAACAATTTCATGAAAAATCAATCTCAGCTGACTGTGCCAAGGACAAAGCACTTCAGCTAAGTAATTCACCGGGTGCATCCTCTG
CCTTTCTTAAGGCAGAAACTGAACATAACAAGGAAGTGGCCCCACAAGTCTCACTGCTGACTCAAGGTGGGGCTGCCCAGAGCCTGGTGC
CACCAGGAGCAAGTCTGGCCACAGAGTCAAGGCAGGAAGCCTTGGGGGCAGAGCACAACAGCTCCGCTCTGTTGCCATGTCTGTTGCCAG
ATGGGTCTGATGGGTCCGATGCTCTTAACTGCAGTCAGCCTTCTCCTCTGGATGTTGGAGTGAAGAACACTCAATCCCAGGGAAAAACTA
GTGCCTGTGAGGTGAGTGGAGATGTGACGGTGGATGTTACAGGGGTTAATGCTCTACAAGGTATGGCTGAGCCCAGAAGAGAGAATATAT
CACACAACACCCAAGACATCCTGATTCCAAACGTCTTGTTGAGCCAAGAGAAGAATGCCGTTCTAGGTTTGCCAGTGGCTCTACAGGACA
AAGCTGTGACTGACCCACAGGGAGTTGGAACCCCAGAGATGATACCTCTTGATTGGGAGAAAGGGAAGCTGGAGGGAGCAGACCACAGCT
GTACCATGGGTGACGCTGAGGAAGCCCAAATAGACGATGAAGCACATCCTGTCCTACTGCAGCCTGTTGCCAAGGAGCTCCCCACAGACA
TGGAGCTCTCAGCCCATGATGATGGGGCCCCAGCTGGTGTGAGGGAAGTCATGCGAGCCCCGCCTTCAGGCAGGGAAAGGAGCACTCCCT
CTCTACCTTGCATGGTCTCTGCCCAGGACGCACCTCTGCCTAAGGGGGCAGACTTGATAGAGGAGGCTGCCAGCCGTATAGTGGATGCTG
TCATCGAACAAGTCAAGGCCGCTGGAGCACTGCTTACTGAGGGGGAGGCCTGTCACATGTCACTGTCCAGCCCTGAGTTGGGTCCTCTCA
CTAAAGGACTAGAGAGTGCTTTTACAGAAAAAGTGAGTACTTTCCCACCTGGGGAGAGCCTACCAATGGGCAGTACTCCTGAGGAAGCCA
CGGGGAGCCTTGCAGGATGTTTTGCTGGAAGGGAGGAGCCAGAGAAGATCATTTTACCTGTCCAGGGGCCTGAGCCAGCAGCAGAAATGC
CAGACGTGAAAGCTGAAGATGAAGTGGATTTTAGAGCAAGTTCAATTTCTGAAGAAGTGGCTGTAGGGAGCATAGCTGCTACACTGAAGA
TGAAGCAAGGCCCAATGACCCAGGCGGTCTCCTACCTGCCCCGGATGTGCCTCCAGTACCCATCCCTGTCCCCAGCCCAGCCCAGCTCAG
ATGAGGAGGAGGGCGAGCGGCAGAGCCCCCCACTGGAGGTGTCTGACGGCGAGGCGGATGGCCTGGAGCCCGGGCCTGGGCTCCTGCCTG
GGGAGACAGGCAGCAAGAAGAAGATCCGCCTGTACCAGTTCCTGTTGGACCTGCTCCGCAGCGGCGACATGAAGGACAGCATCTGGTGGG
TGGACAAGGACAAGGGCACCTTCCAGTTCTCGTCCAAGCACAAGGAGGCGCTGGCGCACCGCTGGGGCATCCAGAAGGGCAACCGCAAGA
AGATGACCTACCAGAAGATGGCGCGCGCGCTGCGCAACTACGGCAAGACGGGCGAGGTCAAGAAGGTGAAGAAGAAGCTCACCTACCAGT
TCAGCGGCGAAGTGCTGGGCCGCGGGGGCCTGGCCGAGCGGCGCCACCCGCCCCACTGAGCCCGCAGCCCCCGCCGGGCCCCGCCAGGCC
TCCCCGCTGGCCATAGCATTAAGCCCTCGCCCGGCCCGGACACAGGGAGGACGCTCCCGGGGCCCAGAGGCAGGACTGTGGCGGGCCGGG
CCTCGCCTCACCCGCCCCCTCCCCCCACTCCAGGCCCCCTCCACATCCCGCTTCGCCTCCCTCCAGGACTCCACCCCGGCTCCCGGACGC
CAGCTGGGCGTCAGACCCCACCGGGGCAACCTTGCAGAGGACGACCCGGGGTACTGCCTTGGGAGTCTCAAGTCCGTATGTAAATCAGAT

>3320_3320_4_AKAP13-SPI1_AKAP13_chr15_86129054_ENST00000394518_SPI1_chr11_47380557_ENST00000378538_length(amino acids)=1547AA_BP=1387
MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAPGHDCCETVKVQLCASKEGLPVFVVAEEDFH
FVQDEAYDAAQFLATSAGNQQALNFTRFLDQSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT
WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYGDCSVRHHRELDIYTLTSESDSHHEHPFPGD
GCTGPIFKLMNIQQQLMKTNLKQMDSLMPLMMTAQDPSSAPETDGQFLPCAPEPTDPQRLSSSEETESTQCCPGSPVAQTESPCDLSSIV
EEENTDRSCRKKNKGVERKGEEVEPAPIVDSGTVSDQDSCLQSLPDCGVKGTEGLSSCGNRNEETGTKSSGMPTDQESLSSGDAVLQRDL
VMEPGTAQYSSGGELGGISTTNVSTPDTAGEMEHGLMNPDATVWKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPNCAPAA
SSLDGNKPAESSLAFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKDKISDGLEPYTLLAAGIGEAMSPSDLALLGLEEDVM
PHQNSETNSSHAQSQKGKSSPICSTTGDDKLCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAHTVTSD
PVRDTQERADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQAVISDSTFSLANSPGSESVTKDDALSFVPSQKE
KGTATPELHTATDYRDGPDGNSNEPDTRPLEDRAVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQSVGKA
TLALDSVLTEEGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTPPPGQDTQQFHEKSISADCAKDKALQLSNSPGASSAF
LKAETEHNKEVAPQVSLLTQGGAAQSLVPPGASLATESRQEALGAEHNSSALLPCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGKTSA
CEVSGDVTVDVTGVNALQGMAEPRRENISHNTQDILIPNVLLSQEKNAVLGLPVALQDKAVTDPQGVGTPEMIPLDWEKGKLEGADHSCT
MGDAEEAQIDDEAHPVLLQPVAKELPTDMELSAHDDGAPAGVREVMRAPPSGRERSTPSLPCMVSAQDAPLPKGADLIEEAASRIVDAVI
EQVKAAGALLTEGEACHMSLSSPELGPLTKGLESAFTEKVSTFPPGESLPMGSTPEEATGSLAGCFAGREEPEKIILPVQGPEPAAEMPD
VKAEDEVDFRASSISEEVAVGSIAATLKMKQGPMTQAVSYLPRMCLQYPSLSPAQPSSDEEEGERQSPPLEVSDGEADGLEPGPGLLPGE
TGSKKKIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGEVKKVKKKLTYQFS

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Fusion Gene PPI Analysis for AKAP13-SPI1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAKAP13chr15:86129054chr11:47380557ENST00000361243+8371919_28131387.02818.0ESR1
HgeneAKAP13chr15:86129054chr11:47380557ENST00000394518+8371919_28131387.02814.0ESR1
HgeneAKAP13chr15:86129054chr11:47380557ENST00000560302+141919_28130180.0ESR1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AKAP13-SPI1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AKAP13-SPI1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAKAP13C0007134Renal Cell Carcinoma1CTD_human
HgeneAKAP13C0014859Esophageal Neoplasms1CTD_human
HgeneAKAP13C0033578Prostatic Neoplasms1CTD_human
HgeneAKAP13C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
HgeneAKAP13C0376358Malignant neoplasm of prostate1CTD_human
HgeneAKAP13C0546837Malignant neoplasm of esophagus1CTD_human
HgeneAKAP13C1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneAKAP13C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneAKAP13C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneAKAP13C1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneC0023466Leukemia, Monocytic, Chronic1CTD_human
TgeneC0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneC0023470Myeloid Leukemia1CTD_human
TgeneC0026998Acute Myeloid Leukemia, M11CTD_human
TgeneC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
TgeneC1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human