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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:AKAP11-PACS1 (FusionGDB2 ID:HG11215TG55690) |
Fusion Gene Summary for AKAP11-PACS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AKAP11-PACS1 | Fusion gene ID: hg11215tg55690 | Hgene | Tgene | Gene symbol | AKAP11 | PACS1 | Gene ID | 11215 | 55690 |
| Gene name | A-kinase anchoring protein 11 | phosphofurin acidic cluster sorting protein 1 | |
| Synonyms | AKAP-11|AKAP220|PPP1R44|PRKA11 | MRD17|SHMS | |
| Cytomap | ('AKAP11')('PACS1') 13q14.11 | 11q13.1-q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | A-kinase anchor protein 11A kinase (PRKA) anchor protein 11A-kinase anchor protein 220 kDaA-kinase anchoring protein, 220kDaa kinase anchor protein 220 kDaprotein kinase A anchoring protein 11protein phosphatase 1, regulatory subunit 44 | phosphofurin acidic cluster sorting protein 1PACS-1cytosolic sorting protein PACS-1 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000025301, | ||
| Fusion gene scores | * DoF score | 5 X 3 X 5=75 | 21 X 18 X 12=4536 |
| # samples | 5 | 26 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(26/4536*10)=-4.12483711191377 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AKAP11 [Title/Abstract] AND PACS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | AKAP11(42877999)-PACS1(65960957), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | AKAP11-PACS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AKAP11-PACS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AKAP11-PACS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. AKAP11-PACS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across AKAP11 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across PACS1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LIHC | TCGA-DD-AAD1-01A | AKAP11 | chr13 | 42877999 | + | PACS1 | chr11 | 65960957 | + |
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Fusion Gene ORF analysis for AKAP11-PACS1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000025301 | ENST00000524815 | AKAP11 | chr13 | 42877999 | + | PACS1 | chr11 | 65960957 | + |
| 5CDS-intron | ENST00000025301 | ENST00000529757 | AKAP11 | chr13 | 42877999 | + | PACS1 | chr11 | 65960957 | + |
| In-frame | ENST00000025301 | ENST00000320580 | AKAP11 | chr13 | 42877999 | + | PACS1 | chr11 | 65960957 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000025301 | AKAP11 | chr13 | 42877999 | + | ENST00000320580 | PACS1 | chr11 | 65960957 | + | 9295 | 5292 | 175 | 7827 | 2550 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000025301 | ENST00000320580 | AKAP11 | chr13 | 42877999 | + | PACS1 | chr11 | 65960957 | + | 0.000817353 | 0.99918264 |
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Fusion Genomic Features for AKAP11-PACS1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| AKAP11 | chr13 | 42877999 | + | PACS1 | chr11 | 65960956 | + | 3.26E-08 | 1 |
| AKAP11 | chr13 | 42877999 | + | PACS1 | chr11 | 65960956 | + | 3.26E-08 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for AKAP11-PACS1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:42877999/chr11:65960957) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | AKAP11 | chr13:42877999 | chr11:65960957 | ENST00000025301 | + | 8 | 13 | 238_315 | 1705 | 1902.0 | Compositional bias | Note=Ser-rich |
| Hgene | AKAP11 | chr13:42877999 | chr11:65960957 | ENST00000025301 | + | 8 | 13 | 1650_1663 | 1705 | 1902.0 | Region | Note=PKA-RII subunit binding domain |
| Tgene | PACS1 | chr13:42877999 | chr11:65960957 | ENST00000320580 | 0 | 24 | 353_377 | 118 | 964.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | PACS1 | chr13:42877999 | chr11:65960957 | ENST00000320580 | 0 | 24 | 279_283 | 118 | 964.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | PACS1 | chr13:42877999 | chr11:65960957 | ENST00000320580 | 0 | 24 | 168_175 | 118 | 964.0 | Region | Note=Involved in binding to AP-1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | AKAP11 | chr13:42877999 | chr11:65960957 | ENST00000025301 | + | 8 | 13 | 1705_1767 | 1705 | 1902.0 | Compositional bias | Note=Ser-rich |
| Tgene | PACS1 | chr13:42877999 | chr11:65960957 | ENST00000320580 | 0 | 24 | 112_115 | 118 | 964.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | PACS1 | chr13:42877999 | chr11:65960957 | ENST00000320580 | 0 | 24 | 35_40 | 118 | 964.0 | Compositional bias | Note=Poly-Gln | |
| Tgene | PACS1 | chr13:42877999 | chr11:65960957 | ENST00000320580 | 0 | 24 | 55_84 | 118 | 964.0 | Compositional bias | Note=Ser-rich | |
| Tgene | PACS1 | chr13:42877999 | chr11:65960957 | ENST00000320580 | 0 | 24 | 5_44 | 118 | 964.0 | Compositional bias | Note=Gly-rich | |
| Tgene | PACS1 | chr13:42877999 | chr11:65960957 | ENST00000320580 | 0 | 24 | 62_65 | 118 | 964.0 | Compositional bias | Note=Poly-Ala |
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Fusion Gene Sequence for AKAP11-PACS1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >3276_3276_1_AKAP11-PACS1_AKAP11_chr13_42877999_ENST00000025301_PACS1_chr11_65960957_ENST00000320580_length(transcript)=9295nt_BP=5292nt GCTTGCTTGCCCGGCTCGCTCACGGGTCGTTGAGGCCGGTGACATGTCTGTGAGCTGCGGAGGCTGCGGCCCCCAGATCTTTCTCTTTGA CACTTTGCAATAAAAAAGGGCAGTGAGATTGAATAGGTGTTTTGTGGATTAACTCTTCATTGATTATATACAACAAAAAATAGTTATGGC GACTTTCAGAAACAATCACATGAAGACTAAAGCATCTGTCAGAAAAAGCTTCAGTGAAGATGTGTTCCAGTCTGTAAAGTCTTTATTGCA GAGTCAGAAGGAACTATGCAGTGTAACAGCAGAGGACTGTTTACAGCAGGATGAGCATGCCAATTTAACTGAGGTCACATTTCTGGGTTT TAATGAAGAGACAGATGCTGCTCATATACAGGATTTAGCTGCAGTTTCTTTGGAACTTCCAGATATTCTGAATTCACTCCACTTCTGCAG TCTAAATGAAAATGAAATTATTTGTATGAAGAATATAAATAAACCATTAGATATAAGCAGTGATCCTCTAAATCAGAGTCATCCTTCTGG AATGCTTTGTGTCATGAGAGTGTCACCTACATCACCAAGACTTAGGATTGATTTTATCTTTAGTCTCCTAAGTAAATATGCTACTGGTAT AAGGTACACCTTGGACACATTCTTGCATCAGAAGCACCAACTTGAGACCACTGATGAAGATGATGATGATACTAACCAGTCTGTGTCATC CATAGAGGATGACTTTGTCACTGCTTTTGAGCACTTAGAAGAGGAAGAGACTTCAAAGCCATACAATGATGGAATGAACATTACTGTGCT AAGGAGCCAGTGTGATGCTGCTTCCCAGACGGTTACTGGTCATCATTTAGAAACCCATGATTTAAAGATTCTCATTAGCTCTGGACAGCA GAAGTCATTGGCTAAACCCTCAACTTCCTCAGTGAATGTCCTGGGACATAAAGAACTACCTTCTGTGAAAACTTCAGTCACAACATCAAT TTCAGAGCCTTGGACCCAAAGGAGTTTCTATAGGTCATCTAATGCTTCAGATAAAGATAGTGATTTACAGAAAACATTTTTTTCGTCTTC TCCTGCCTACTCATCTGAATCAGAATGTTCAAGTCCAAGTCCTGTTATTTTCTTGGATGAAGAGGGATATCAAAAAAGCTTAAAAGCAAA ACTTGAGCTGCCTAAAATTCCTGTGATGAAAGATGATATAGAGGATTCAGACTCAGAAGTAAGTGAATTTTTTGATAGTTTTGATCAGTT TGATGAACTAGAACAAACTTTAGAGACTTGCCTGTTTAACAAAGATCCCGTCATAGGGAAGTCATCGCAGAGGAAAGGGCACAAACATGG AAAGTCATGTATGAATCCTCAAAAATTCAAGTTTGATCGTCCAGCTCTCCCAGCTAATGTTAGAAAGCCAACTCCTCGTAAACCAGAATC TCCATATGGTAACCTGTGTGATGCTCCGGATTCTCCTCGCCCAGTGAAGGCATCAAGGGAAGATAGTGGTTTATTTAGTCCTATTCGATC CTCTGCTTTTAGTCCTCTTGGAGGCTGTACTCCAGCTGAATGTTTTTGCCAAACAGATATTGGTGGAGATAGGATTCATGAAAATCATGA TTCTGTTTATTACACCTATGAAGACTATGCAAAAAGCATTTCATGTGAAGTACTAGGCTCAGTTCTTCGTACCCACCATACTAATACCCT ATCAAATATTAACAGTATTAAACATGGAGAAAATAAAACTGTAACTTTTAAGCATGGAAACCTTGATCAAAAAAATAAATCTAAAAATAA ATCCTTAATGATTAAAGATAGCATTCAAAAATTTGCAGCAGATCTTGTGGAAAAAAGTTTTGGCAGTGCATTTAAAGACTTACAGAAAGG AGTCTCTTCATGTACCAATGCTTTGTACCACTTAGCCATCAAATTGACATCATCTGTTTTGCAGATGGCATTTGATGAGCTGAGAAGGCA GCGTGCATTTTCACTAAAAGAACGTGCCATTAGTGGCCTGGCTAACTTTTTGGTGAGTGAAGCTTTATCAAATGCCTTAAAAGATTTACA GTATGTAAAGAAGCAGATATTCACAAACACAGTTGCTAGGTTTGCTGCAGATCTTGCTGAAGAGCTTGTTTTTGAAGGCATCATGGAGGT GTGTCAGTTTTCATATCCTCAAACGCCTGCATCTCCACAGTGTGGGTCGTTTGACTTTGAAGACAAAGTAGTGAAGTTGTATGCAAAAGA TTTGTCTGAATCTGTAATACAGGAAGCATTCATTGAGCTATCACAAGTTGATGTGACCTTTACAACAAAGGCAGCAGTTAGTGTCTCTAC GGATAATATCAAGTATGTGAGTGCAGAAAGTGTAGTGCCATCGACACAGGCTGTCACGTTTTCCCCTTCTTTTCACAATCAAGCAATTAT GGTGACAAAACCAGTGCAGGAATATAAAAAGGAATACACAGTGCAGCAGGCCTTGTTTTGTACTTCTGGAATTGTTACTTCTATACCGGT GCCCTTGGCAGGAAGTGCCCTTCTCCCATATCATATTTCATCTACTGCATGTCAGGCCAAGGCTCATCTGTCATCTGATGATAGTAATTC AAATGGTGATTCTGCCCAAGTGCATATTGCCACAAAAAACAGAGAAGAAAAAGCAGCTTGTCTCAGAAATATTTGTTTACCTTCAGAACA CAATCCAGGTAATCAGAATGATTTTAAACCAACTAATGACGATATTGAAATGCAGAGTTCCTCAAAATTACCAAATGATCCTGCAATTAT TAGCAACTTTTCTGCAGCAGTGGTGCATACGATAGTAAATGAAACTTTAGAGTCAATGACATCATTGGAAGTTACAAAAATGGTTGATGA ACGTACAGATTATTTAACTAAATCTTTAAAGGAGAAAACCCCTCCATTTTCCCACTGTGATCAGGCAGTGCTGCAATGCAGTGAAGCTAG TAGCAATAAGGACATGTTTGCTGACCGGTTATCTAAATCTATTATTAAACATTCCATAGATAAGAGCAAATCAGTGATCCCAAATATAGA TAAAAATGCAGTATACAAGGAAAGCTTGCCTGTTTCTGGAGAAGAATCACAGTTGACACCAGAAAAGTCTCCCAAATTTCCTGACTCTCA GAATCAGTTAACTCACTGCTCACTTTCAGCTGCAAAGGATTGTGTTCCAGAATGTAAAGTTTCTATGGTTCATGGATCCTCCCTAGAGAC ACTGCCATCTTGTCCAGCTGTGACAGGTCAGAAATCTGACTTGAAGGAATCTGCTAAGGATCAACCACTGAAAAAGCATAACTTGAATAG TACATCACTTGAGGCCTTGTCTTTTGGACAGGAAAACCCCTTTCCTCATTCACATACTTTCTCATCTACAGCACTTACCTGTGTAGATGG TTTGCATGTGGAAGATAAACAGAAAGTCAGAGACAGAAATGTAATACCTGATACTCCTCCATCAACTCCTCTAGTACCATCCCGGGCTAG TTCTGAATGGGATATCAAGAAGTTAACTAAAAAGCTCAAGGGAGAATTAGCCAAAGAGTTTGCACCTGCTACACCACCTTCTACTCCACA CAACTCATCTGTTGGTAGTTTGTCTGAGAATGAACAAAATACTATAGAAAAAGAAGAGTTCATGTTGAAACTCATGCGATCTCTTTCTGA AGAAGTTGAGAGTAGTGAAAGTGGAGAGCTCCCAGAAGTGGATGTGAAGTCGGAGCACTCAGGGAAGAAGGTTCAGTTTGCAGAAGCATT AGCTACACACATCCTTTCTCTTGCAACTGAAATGGCAGCTTCCCATTTAGATAACAAAATAATTCAAGAACCCAAGGTTAAAAACCCTTG CTTAAATGTGCAAAGTCAAAGAAGTGTGTCGCCTACTTTTTTAAACCCCTCAGACGAAAATTTGAAAACATTATGCAATTTTGCGGGTGA TCTGGCAGCAGAAGTCATTACAGAAGCTGAGAAAATAGCAAAAGTCCGAAATTGTATGCTTTTCAAGCAAAAGAAGAACAGTTGTTATGC TGATGGTGACGAAGATTATAAAGTAGAAGAGAAGTTGGATATAGAGGCTGTAGTGCACCCAAGAGAAGTGGATCCGTTTATTCTTTCATT ACCACCAAGTTCTTGTATGTCAGGTCTGATGTATAAGTATCCCAGCTGTGAAAGTGTGACAGATGAATATGCAGGTCACCTTATTCAGAT ACTAAAACAGGAAGGTGGTAATAGTGAGTTGATAATGGATCAGTATGCCAATAGGCTTGCCTACCGATCTGTTAAATCAGGATTACAGGA AGCAGCTAAGACAACCAAAGTGCAGTGCAACTCAAGAATGTTCCCTGTGCCAAGTTCACAAGTGAAAACAAACAAGGAACTGTTAATGTT TTCAAACAAAGAGCACCACCAAGAAGCAGACAAAAAGAGACAAAGTAAAAGAAATGAAGGTTACTTTTGTAAAAATCAAACTTGTGAAAG GACCCTGGATCCATATAGAAATGAGGTCTCCCAACTGTATAGTTTTTCAACCTCTCTGGTTCACAGCATAACAAAAGATGCTAAGGAAGA GTTGACAGCCTCTCTAGTTGGCCTACCAAAATCCTTAACAGATTCTTGCTTGTTTGAAAAATCTGGATATGAAGAAGATAATGAGTGTCA CGTTACACCAGAATTGCCTAAGTCTCTTCAGCCTTCCTCACAAAATCACAGGTTTTACCACAGCACTGGCAGTTTAAATGGATATGGTTG TGGAGACAATGTTGTTCAAGCTGTAGAACAGTATGCCAAAAAAGTAGTGGATGACACTCTAGAGCTAACTCTAGGATCTACAGTGTTCCG AGTGTCTGAGACCACAAAATCAGCAGACAGGGTCACTTATGCAGAAAAGTTGTCACCTCTTACAGGTCAAGCTTGCAGATACTGTGACCT TAAAGAACTCCACAATTGCACTGGAAATTCATCTCAGCACTTTTTCAGACAGGGTTCTCTCGCCAGTAGTAAGCCAGCTTCTAATCCAAA ATTTAGCAGCCGCTATCAGAAATCTAGGATTTTTCATCTCAGTGTCCCTCAGATTCATGTTAATCTTGATAAGAAGGCAGTGCTTGCTGA GAAGATAGTTGCTGAAGCCATTGAAAAAGCTGAGCGAGAGCTGAGCAGTACCAGCCTGGCAGCCGACAGTGGGATCGGACAGGAGGGTGC CAGCTTTGCTGAAAGCCTTGCCACAGAAACCATGACAGCAGCTGTCACAAATGTTGGGCATGCTGTTAGCAGGCTATTCAGCTTGACCCT GAAGAAACTCGTCATGCTAAAAGAAATGGACAAAGATCTTAACTCAGTGGTCATCGCTGTGAAGCTGCAGGGTTCAAAAAGAATTCTTCG CTCCAACGAGATCGTCCTTCCAGCTAGTGGACTGGTGGAAACAGAGCTCCAATTAACCTTCTCCCTTCAGTACCCTCATTTCCTTAAGCG AGATGCCAACAAGCTGCAGATCATGCTGCAAAGGAGAAAACGTTACAAGAATCGGACCATCTTGGGCTATAAGACCTTGGCCGTGGGACT CATCAACATGGCAGAGGTGATGCAGCATCCTAATGAAGGCGCACTGGTGCTTGGCCTACACAGCAACGTGAAGGATGTCTCTGTGCCTGT GGCAGAAATAAAGATCTACTCCCTGTCCAGCCAACCCATTGACCATGAAGGAATCAAATCCAAGCTTTCTGATCGTTCTCCTGATATTGA CAATTATTCTGAGGAAGAGGAAGAGAGTTTCTCATCAGAACAGGAAGGCAGTGATGATCCATTGCATGGGCAGGACTTGTTCTACGAAGA CGAAGATCTCCGGAAAGTGAAGAAGACCCGGAGGAAACTAACCTCAACCTCTGCCATCACAAGGCAACCTAACATCAAACAGAAGTTTGT GGCCCTCCTGAAGCGGTTTAAAGTTTCAGATGAGGTGGGCTTTGGGCTGGAGCATGTGTCCCGCGAGCAGATCCGGGAAGTGGAAGAGGA CTTGGATGAATTGTATGACAGTCTGGAGATGTACAACCCCAGCGACAGTGGCCCTGAGATGGAGGAGACAGAAAGCATCCTCAGCACGCC AAAGCCCAAGCTCAAGCCTTTCTTTGAGGGGATGTCGCAGTCCAGCTCCCAGACGGAGATTGGCAGCCTCAACAGCAAAGGCAGCCTCGG AAAAGACACCACCAGCCCTATGGAATTGGCTGCTCTAGAAAAAATTAAATCTACTTGGATTAAAAACCAAGATGACAGCTTGACTGAAAC AGACACTCTGGAAATCACTGACCAGGACATGTTTGGAGATGCCAGCACGAGTCTGGTTGTGCCGGAGAAAGTCAAAACTCCCATGAAGTC CAGTAAAACGGATCTCCAGGGCTCTGCCTCCCCCAGCAAAGTGGAGGGGGTGCACACACCCCGGCAGAAGAGGAGCACGCCCCTGAAGGA GCGGCAGCTCTCCAAGCCCCTAAGTGAGAGGACCAACAGTTCCGACAGCGAGCGCTCCCCAGATCTGGGCCACAGCACGCAGATTCCAAG AAAGGTGGTGTATGACCAGCTCAATCAGATCCTGGTGTCAGATGCAGCCCTCCCAGAAAATGTCATTCTGGTGAACACCACTGACTGGCA GGGCCAGTATGTGGCTGAGCTGCTCCAGGACCAGCGGAAGCCTGTGGTGTGCACCTGCTCCACCGTGGAGGTCCAGGCCGTGCTGTCCGC CCTGCTCACCCGGATCCAGCGCTACTGCAACTGCAACTCTTCCATGCCGAGGCCAGTGAAGGTGGCTGCTGTGGGAGGCCAGAGCTACCT GAGCTCCATCCTCAGGTTCTTTGTCAAGTCCCTGGCCAACAAGACCTCCGACTGGCTTGGCTACATGCGCTTCCTCATCATCCCCCTCGG TTCTCACCCTGTGGCCAAATACTTGGGGTCAGTCGACAGTAAATACAGTAGTTCCTTCCTGGATTCTGGTTGGAGAGATCTGTTCAGTCG CTCGGAGCCACCAGTGTCAGAGCAACTGGACGTGGCAGGGCGGGTGATGCAGTACGTCAACGGGGCAGCCACGACACACCAGCTTCCCGT GGCCGAAGCCATGCTGACTTGCCGGCATAAGTTCCCTGATGAAGACTCCTATCAGAAGTTTATTCCCTTCATTGGCGTGGTGAAGGTGGG TCTGGTTGAAGACTCTCCCTCCACAGCAGGCGATGGGGACGATTCTCCTGTGGTCAGCCTTACTGTGCCCTCCACATCACCACCCTCCAG CTCGGGCCTGAGCCGAGACGCCACGGCCACCCCTCCCTCCTCCCCATCTATGAGCAGCGCCCTGGCCATCGTGGGGAGCCCTAATAGCCC ATATGGGGACGTGATTGGCCTCCAGGTGGACTACTGGCTGGGCCACCCCGGGGAGCGGAGGAGGGAAGGCGACAAGAGGGACGCCAGCTC GAAGAACACCCTCAAGAGTGTCTTCCGCTCAGTGCAGGTGTCCCGCCTGCCCCATAGTGGGGAGGCCCAGCTTTCTGGCACCATGGCCAT GACTGTGGTCACCAAAGAAAAGAACAAGAAAGTTCCCACCATCTTCCTGAGCAAGAAACCCCGAGAAAAGGAGGTGGATTCTAAGAGCCA GGTCATTGAAGGCATCAGCCGCCTCATCTGCTCAGCCAAGCAGCAGCAGACTATGCTGAGAGTGTCCATCGATGGGGTCGAGTGGAGTGA CATCAAGTTCTTCCAGCTGGCAGCCCAGTGGCCCACCCATGTCAAGCACTTTCCAGTGGGACTCTTCAGTGGCAGCAAGGCCACCTGAGG CCCTGTCTCCCAGCCACTTTCCCTCCTGGCACTGCCACCAGCCTCACCGCCTGCGGGCAGGGGGAGGCCAGCAGGCCCGGGCCCAGCACC CCTTCCCTGGCACCAGGGTCTGCCTCTCACTCGCCCAGGTCCCGAAGGACACTGCCACAGGGACGCCTTCCCTCCCCTCCCCTCCAGCCC ACCCCTGCACAGCCCCTCCTCCTTCCCGCTTTTCCCCTTCTCCCTCCTGCTCCAGGCCCAAGGCGTGTTGGTTTTGCCTTCTGGTGCCCA TAGTCCCCTGGACTGAGTCCCCCAGGCCTTCCTTCACCCGACTTCCAAACTCTTCCTTGTGGTATCAGTTTCCTTCTCGGAAATGAGAAA GCTGGAATCCTGGTCCCCAGCAGGAGAGCCTAGTCCTCCCCCAGCCCCTCCAGCCACCAGGGTGTCCTCTAGGATGCAGCTGCCAGATCC ACTCACTCTGCTGCCTCCAGCAGGACCCAAGGCCACTTTCAACTCTTATGGGGTTCTCCACCTGCCCCAGAGCTTCTCAAGGGAGGGTAA GGGGGCACCCTGAGCCCACAGGACCCCTACTTCACAGCTCACAGGGGCAGGAGGCAGCTCCCCTGCCTCCAGGACCCTGTTGCTATGGTG ACACAGCGTTTCTAGGACAGAGGGGCCTCCCAGTCTCCCCCCACCACCCGTGCACGACTTCCTCACCACCCCCAGGTTCCCTGCAGATGT CGTGTGTGTCCTGAGTGTTTCTTTGGTTCTTTGCACGCCAAGTCTCTTGGTTGTACCATGTGACACACCCTGTGCACTGGTCGCTGTCTT CGTGGCTTCCACCCTTGTTAATGATGCTCCTGCCTCTGCCTCCCAGCCCCTCACCCAGCACAGCTCTGCCTGGACTTGGAGAGATGGGAG GCAGACCCCCACCACCATACATGCTGTCTGTGGCCCCTCAGACATTCTGTTTCATCTCCCATTCATCTCCCTCCTCCCACCGTGTCAGTT TTTCTGCCTTTCCCTGCTCTGTTCTTCCCCCTCCTTAGGCCCCAGCCTGGGCCCAGACCCATCCTCCCAGCCAGGTTTCCCTCCAGCAGG CTCCTTCCCTCCCTGTCACCTCCCTCTCACCAACCCGGGGTCTGAGCCCCTCATTCCTGACCGTCCGTGTTCTCAGGAGTGGTTGAGGAC ACAGGGCCCCAGCCCAGCCCTCTGCACCCCCCAGCCCGGCCATCTGCGCCCCACAGCCCCTTTGGAGCTTTTCTCTTGTCCTCTCACTCC TTCCCAGAAGTTTTTGCACAGAACTTCATTTTGAAAGTGTTTTTCTCATTCTCCATACCTCCCCCAAGCTCTCCTCCAGCCCTTCCCAGG GCTCAGCCCTGCTGTCCTGAGCGTCTCCTGGGCCAGAGAGAGGAGATGGGGGTGGGAGGGACTGAGTTGATGTTGGGTTTTTCATTCAAT >3276_3276_1_AKAP11-PACS1_AKAP11_chr13_42877999_ENST00000025301_PACS1_chr11_65960957_ENST00000320580_length(amino acids)=2550AA_BP=1704 MATFRNNHMKTKASVRKSFSEDVFQSVKSLLQSQKELCSVTAEDCLQQDEHANLTEVTFLGFNEETDAAHIQDLAAVSLELPDILNSLHF CSLNENEIICMKNINKPLDISSDPLNQSHPSGMLCVMRVSPTSPRLRIDFIFSLLSKYATGIRYTLDTFLHQKHQLETTDEDDDDTNQSV SSIEDDFVTAFEHLEEEETSKPYNDGMNITVLRSQCDAASQTVTGHHLETHDLKILISSGQQKSLAKPSTSSVNVLGHKELPSVKTSVTT SISEPWTQRSFYRSSNASDKDSDLQKTFFSSSPAYSSESECSSPSPVIFLDEEGYQKSLKAKLELPKIPVMKDDIEDSDSEVSEFFDSFD QFDELEQTLETCLFNKDPVIGKSSQRKGHKHGKSCMNPQKFKFDRPALPANVRKPTPRKPESPYGNLCDAPDSPRPVKASREDSGLFSPI RSSAFSPLGGCTPAECFCQTDIGGDRIHENHDSVYYTYEDYAKSISCEVLGSVLRTHHTNTLSNINSIKHGENKTVTFKHGNLDQKNKSK NKSLMIKDSIQKFAADLVEKSFGSAFKDLQKGVSSCTNALYHLAIKLTSSVLQMAFDELRRQRAFSLKERAISGLANFLVSEALSNALKD LQYVKKQIFTNTVARFAADLAEELVFEGIMEVCQFSYPQTPASPQCGSFDFEDKVVKLYAKDLSESVIQEAFIELSQVDVTFTTKAAVSV STDNIKYVSAESVVPSTQAVTFSPSFHNQAIMVTKPVQEYKKEYTVQQALFCTSGIVTSIPVPLAGSALLPYHISSTACQAKAHLSSDDS NSNGDSAQVHIATKNREEKAACLRNICLPSEHNPGNQNDFKPTNDDIEMQSSSKLPNDPAIISNFSAAVVHTIVNETLESMTSLEVTKMV DERTDYLTKSLKEKTPPFSHCDQAVLQCSEASSNKDMFADRLSKSIIKHSIDKSKSVIPNIDKNAVYKESLPVSGEESQLTPEKSPKFPD SQNQLTHCSLSAAKDCVPECKVSMVHGSSLETLPSCPAVTGQKSDLKESAKDQPLKKHNLNSTSLEALSFGQENPFPHSHTFSSTALTCV DGLHVEDKQKVRDRNVIPDTPPSTPLVPSRASSEWDIKKLTKKLKGELAKEFAPATPPSTPHNSSVGSLSENEQNTIEKEEFMLKLMRSL SEEVESSESGELPEVDVKSEHSGKKVQFAEALATHILSLATEMAASHLDNKIIQEPKVKNPCLNVQSQRSVSPTFLNPSDENLKTLCNFA GDLAAEVITEAEKIAKVRNCMLFKQKKNSCYADGDEDYKVEEKLDIEAVVHPREVDPFILSLPPSSCMSGLMYKYPSCESVTDEYAGHLI QILKQEGGNSELIMDQYANRLAYRSVKSGLQEAAKTTKVQCNSRMFPVPSSQVKTNKELLMFSNKEHHQEADKKRQSKRNEGYFCKNQTC ERTLDPYRNEVSQLYSFSTSLVHSITKDAKEELTASLVGLPKSLTDSCLFEKSGYEEDNECHVTPELPKSLQPSSQNHRFYHSTGSLNGY GCGDNVVQAVEQYAKKVVDDTLELTLGSTVFRVSETTKSADRVTYAEKLSPLTGQACRYCDLKELHNCTGNSSQHFFRQGSLASSKPASN PKFSSRYQKSRIFHLSVPQIHVNLDKKAVLAEKIVAEAIEKAERELSSTSLAADSGIGQEGASFAESLATETMTAAVTNVGHAVSRLFSL TLKKLVMLKEMDKDLNSVVIAVKLQGSKRILRSNEIVLPASGLVETELQLTFSLQYPHFLKRDANKLQIMLQRRKRYKNRTILGYKTLAV GLINMAEVMQHPNEGALVLGLHSNVKDVSVPVAEIKIYSLSSQPIDHEGIKSKLSDRSPDIDNYSEEEEESFSSEQEGSDDPLHGQDLFY EDEDLRKVKKTRRKLTSTSAITRQPNIKQKFVALLKRFKVSDEVGFGLEHVSREQIREVEEDLDELYDSLEMYNPSDSGPEMEETESILS TPKPKLKPFFEGMSQSSSQTEIGSLNSKGSLGKDTTSPMELAALEKIKSTWIKNQDDSLTETDTLEITDQDMFGDASTSLVVPEKVKTPM KSSKTDLQGSASPSKVEGVHTPRQKRSTPLKERQLSKPLSERTNSSDSERSPDLGHSTQIPRKVVYDQLNQILVSDAALPENVILVNTTD WQGQYVAELLQDQRKPVVCTCSTVEVQAVLSALLTRIQRYCNCNSSMPRPVKVAAVGGQSYLSSILRFFVKSLANKTSDWLGYMRFLIIP LGSHPVAKYLGSVDSKYSSSFLDSGWRDLFSRSEPPVSEQLDVAGRVMQYVNGAATTHQLPVAEAMLTCRHKFPDEDSYQKFIPFIGVVK VGLVEDSPSTAGDGDDSPVVSLTVPSTSPPSSSGLSRDATATPPSSPSMSSALAIVGSPNSPYGDVIGLQVDYWLGHPGERRREGDKRDA SSKNTLKSVFRSVQVSRLPHSGEAQLSGTMAMTVVTKEKNKKVPTIFLSKKPREKEVDSKSQVIEGISRLICSAKQQQTMLRVSIDGVEW -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for AKAP11-PACS1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for AKAP11-PACS1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for AKAP11-PACS1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C3714756 | Intellectual Disability | 2 | GENOMICS_ENGLAND | |
| Tgene | C0005586 | Bipolar Disorder | 1 | CTD_human | |
| Tgene | C0005587 | Depression, Bipolar | 1 | CTD_human | |
| Tgene | C0013146 | Drug abuse | 1 | CTD_human | |
| Tgene | C0013170 | Drug habituation | 1 | CTD_human | |
| Tgene | C0013222 | Drug Use Disorders | 1 | CTD_human | |
| Tgene | C0024713 | Manic Disorder | 1 | CTD_human | |
| Tgene | C0028754 | Obesity | 1 | CTD_human | |
| Tgene | C0029231 | Organic Mental Disorders, Substance-Induced | 1 | CTD_human | |
| Tgene | C0038580 | Substance Dependence | 1 | CTD_human | |
| Tgene | C0038586 | Substance Use Disorders | 1 | CTD_human | |
| Tgene | C0236969 | Substance-Related Disorders | 1 | CTD_human | |
| Tgene | C0338831 | Manic | 1 | CTD_human | |
| Tgene | C0740858 | Substance abuse problem | 1 | CTD_human | |
| Tgene | C1510472 | Drug Dependence | 1 | CTD_human | |
| Tgene | C3554343 | MENTAL RETARDATION, AUTOSOMAL DOMINANT 17 | 1 | GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
| Tgene | C4316881 | Prescription Drug Abuse | 1 | CTD_human |
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