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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PDCD10-HSF1 (FusionGDB2 ID:HG11235TG3297)

Fusion Gene Summary for PDCD10-HSF1

check button Fusion gene summary
Fusion gene informationFusion gene name: PDCD10-HSF1
Fusion gene ID: hg11235tg3297
HgeneTgene
Gene symbol

PDCD10

HSF1

Gene ID

11235

3297

Gene nameprogrammed cell death 10heat shock transcription factor 1
SynonymsCCM3|TFAR15HSTF1
Cytomap('PDCD10')('HSF1')

3q26.1

8q24.3

Type of geneprotein-codingprotein-coding
Descriptionprogrammed cell death protein 10TF-1 cell apoptosis-related protein 15apoptosis-related protein 15cerebral cavernous malformations 3 proteinheat shock factor protein 1
Modification date2020031320200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000470131, ENST00000471885, 
ENST00000473645, ENST00000497056, 
ENST00000392750, ENST00000461494, 
ENST00000487678, ENST00000487947, 
ENST00000492396, 
Fusion gene scores* DoF score4 X 4 X 3=488 X 9 X 5=360
# samples 59
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDCD10 [Title/Abstract] AND HSF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPDCD10(167452594)-HSF1(145537509), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDCD10

GO:0008284

positive regulation of cell proliferation

17360971|23541896

HgenePDCD10

GO:0030335

positive regulation of cell migration

23541896

HgenePDCD10

GO:0032874

positive regulation of stress-activated MAPK cascade

22652780

HgenePDCD10

GO:0042542

response to hydrogen peroxide

22291017

HgenePDCD10

GO:0043066

negative regulation of apoptotic process

17360971

HgenePDCD10

GO:0043406

positive regulation of MAP kinase activity

17360971

TgeneHSF1

GO:0000122

negative regulation of transcription by RNA polymerase II

8926278|9341107

TgeneHSF1

GO:0000165

MAPK cascade

12917326

TgeneHSF1

GO:0009299

mRNA transcription

21597468

TgeneHSF1

GO:0034605

cellular response to heat

7935471|9222587|9341107|10359787|10413683|10747973|11514557|11583998|12917326|14707147|16554823|17897941|21085490|26159920

TgeneHSF1

GO:0034620

cellular response to unfolded protein

15016915

TgeneHSF1

GO:0034622

cellular protein-containing complex assembly

11583998

TgeneHSF1

GO:0045944

positive regulation of transcription by RNA polymerase II

9341107|10561509|11514557|12917326|16278218|21085490

TgeneHSF1

GO:0061408

positive regulation of transcription from RNA polymerase II promoter in response to heat stress

7760831|9499401|10747973|12659875|12665592|15016915|25963659|26754925

TgeneHSF1

GO:0071276

cellular response to cadmium ion

10359787|11514557|15016915|25963659

TgeneHSF1

GO:0071280

cellular response to copper ion

15016915

TgeneHSF1

GO:0071480

cellular response to gamma radiation

26359349

TgeneHSF1

GO:0072738

cellular response to diamide

15016915

TgeneHSF1

GO:1900034

regulation of cellular response to heat

11583998

TgeneHSF1

GO:1903936

cellular response to sodium arsenite

15016915



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-NA-A5I1-01APDCD10chr3

167452594

-HSF1chr8

145537509

+
ChimerDB4UCSTCGA-NA-A5I1PDCD10chr3

167452594

-HSF1chr8

145537509

+


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Fusion Gene ORF analysis for PDCD10-HSF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000470131ENST00000528838PDCD10chr3

167452594

-HSF1chr8

145537509

+
5UTR-3CDSENST00000471885ENST00000528838PDCD10chr3

167452594

-HSF1chr8

145537509

+
5UTR-3CDSENST00000473645ENST00000528838PDCD10chr3

167452594

-HSF1chr8

145537509

+
5UTR-3CDSENST00000497056ENST00000528838PDCD10chr3

167452594

-HSF1chr8

145537509

+
5UTR-3UTRENST00000470131ENST00000528842PDCD10chr3

167452594

-HSF1chr8

145537509

+
5UTR-3UTRENST00000471885ENST00000528842PDCD10chr3

167452594

-HSF1chr8

145537509

+
5UTR-3UTRENST00000473645ENST00000528842PDCD10chr3

167452594

-HSF1chr8

145537509

+
5UTR-3UTRENST00000497056ENST00000528842PDCD10chr3

167452594

-HSF1chr8

145537509

+
5UTR-intronENST00000470131ENST00000400780PDCD10chr3

167452594

-HSF1chr8

145537509

+
5UTR-intronENST00000471885ENST00000400780PDCD10chr3

167452594

-HSF1chr8

145537509

+
5UTR-intronENST00000473645ENST00000400780PDCD10chr3

167452594

-HSF1chr8

145537509

+
5UTR-intronENST00000497056ENST00000400780PDCD10chr3

167452594

-HSF1chr8

145537509

+
intron-3CDSENST00000392750ENST00000528838PDCD10chr3

167452594

-HSF1chr8

145537509

+
intron-3CDSENST00000461494ENST00000528838PDCD10chr3

167452594

-HSF1chr8

145537509

+
intron-3CDSENST00000487678ENST00000528838PDCD10chr3

167452594

-HSF1chr8

145537509

+
intron-3CDSENST00000487947ENST00000528838PDCD10chr3

167452594

-HSF1chr8

145537509

+
intron-3CDSENST00000492396ENST00000528838PDCD10chr3

167452594

-HSF1chr8

145537509

+
intron-3UTRENST00000392750ENST00000528842PDCD10chr3

167452594

-HSF1chr8

145537509

+
intron-3UTRENST00000461494ENST00000528842PDCD10chr3

167452594

-HSF1chr8

145537509

+
intron-3UTRENST00000487678ENST00000528842PDCD10chr3

167452594

-HSF1chr8

145537509

+
intron-3UTRENST00000487947ENST00000528842PDCD10chr3

167452594

-HSF1chr8

145537509

+
intron-3UTRENST00000492396ENST00000528842PDCD10chr3

167452594

-HSF1chr8

145537509

+
intron-intronENST00000392750ENST00000400780PDCD10chr3

167452594

-HSF1chr8

145537509

+
intron-intronENST00000461494ENST00000400780PDCD10chr3

167452594

-HSF1chr8

145537509

+
intron-intronENST00000487678ENST00000400780PDCD10chr3

167452594

-HSF1chr8

145537509

+
intron-intronENST00000487947ENST00000400780PDCD10chr3

167452594

-HSF1chr8

145537509

+
intron-intronENST00000492396ENST00000400780PDCD10chr3

167452594

-HSF1chr8

145537509

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for PDCD10-HSF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PDCD10chr3167452593-HSF1chr8145537508+0.0596193970.94038063
PDCD10chr3167452593-HSF1chr8145537508+0.0596193970.94038063
PDCD10chr3167452593-HSF1chr8145537508+0.0596193970.94038063
PDCD10chr3167452593-HSF1chr8145537508+0.0596193970.94038063


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for PDCD10-HSF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:167452594/:145537509)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PDCD10-HSF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PDCD10-HSF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PDCD10-HSF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PDCD10-HSF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDCD10C1864040Cerebral Cavernous Malformations 31CTD_human;GENOMICS_ENGLAND
HgenePDCD10C2919945Cavernous Hemangioma of Brain1GENOMICS_ENGLAND
HgenePDCD10C2931263Familial cerebral cavernous malformation1GENOMICS_ENGLAND
TgeneC0006826Malignant Neoplasms1CTD_human
TgeneC0027651Neoplasms1CTD_human
TgeneC0086692Benign Neoplasm1CTD_human
TgeneC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgeneC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
TgeneC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human