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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:CHP1-ANXA2 (FusionGDB2 ID:HG11261TG302)

Fusion Gene Summary for CHP1-ANXA2

check button Fusion gene summary
Fusion gene informationFusion gene name: CHP1-ANXA2
Fusion gene ID: hg11261tg302
HgeneTgene
Gene symbol

CHP1

ANXA2

Gene ID

11261

302

Gene namecalcineurin like EF-hand protein 1annexin A2
SynonymsCHP|SLC9A1BP|SPAX9|Sid470p|p22|p24ANX2|ANX2L4|CAL1H|HEL-S-270|LIP2|LPC2|LPC2D|P36|PAP-IV
Cytomap('CHP1')('ANXA2')

15q15.1

15q22.2

Type of geneprotein-codingprotein-coding
Descriptioncalcineurin B homologous protein 1EF-hand calcium-binding domain-containing protein p22SLC9A1 binding proteincalcineurin B homologcalcineurin B-like proteincalcineurin homologous proteincalcium binding protein P22calcium-binding protein CHPcalciumannexin A2annexin IIannexin-2calpactin I heavy chaincalpactin I heavy polypeptidecalpactin-1 heavy chainchromobindin 8epididymis secretory protein Li 270epididymis secretory sperm binding proteinlipocortin IIplacental anticoagulant protein IVpr
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000334660, ENST00000560397, 
ENST00000558351, 
Fusion gene scores* DoF score11 X 13 X 7=100133 X 12 X 13=5148
# samples 1539
** MAII scorelog2(15/1001*10)=-2.73840756834011
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(39/5148*10)=-3.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHP1 [Title/Abstract] AND ANXA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHP1(41523647)-ANXA2(60656722), # samples:1
Anticipated loss of major functional domain due to fusion event.CHP1-ANXA2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHP1-ANXA2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHP1-ANXA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CHP1-ANXA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHP1

GO:0010923

negative regulation of phosphatase activity

10593895

HgeneCHP1

GO:0032088

negative regulation of NF-kappaB transcription factor activity

10593895

HgeneCHP1

GO:0032417

positive regulation of sodium:proton antiporter activity

8901634|11350981

HgeneCHP1

GO:0042308

negative regulation of protein import into nucleus

10593895

HgeneCHP1

GO:0051453

regulation of intracellular pH

8901634|15035633

HgeneCHP1

GO:0070885

negative regulation of calcineurin-NFAT signaling cascade

10593895

TgeneANXA2

GO:0001921

positive regulation of receptor recycling

22848640

TgeneANXA2

GO:0031340

positive regulation of vesicle fusion

2138016

TgeneANXA2

GO:0032804

negative regulation of low-density lipoprotein particle receptor catabolic process

22848640

TgeneANXA2

GO:0036035

osteoclast development

7961821

TgeneANXA2

GO:1905581

positive regulation of low-density lipoprotein particle clearance

22848640

TgeneANXA2

GO:1905597

positive regulation of low-density lipoprotein particle receptor binding

22848640

TgeneANXA2

GO:1905602

positive regulation of receptor-mediated endocytosis involved in cholesterol transport

22848640


check buttonFusion gene breakpoints across CHP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ANXA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8530-01ACHP1chr15

41523647

+ANXA2chr15

60656722

-


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Fusion Gene ORF analysis for CHP1-ANXA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000334660ENST00000557937CHP1chr15

41523647

+ANXA2chr15

60656722

-
5CDS-5UTRENST00000560397ENST00000557937CHP1chr15

41523647

+ANXA2chr15

60656722

-
In-frameENST00000334660ENST00000332680CHP1chr15

41523647

+ANXA2chr15

60656722

-
In-frameENST00000334660ENST00000396024CHP1chr15

41523647

+ANXA2chr15

60656722

-
In-frameENST00000334660ENST00000421017CHP1chr15

41523647

+ANXA2chr15

60656722

-
In-frameENST00000334660ENST00000451270CHP1chr15

41523647

+ANXA2chr15

60656722

-
In-frameENST00000560397ENST00000332680CHP1chr15

41523647

+ANXA2chr15

60656722

-
In-frameENST00000560397ENST00000396024CHP1chr15

41523647

+ANXA2chr15

60656722

-
In-frameENST00000560397ENST00000421017CHP1chr15

41523647

+ANXA2chr15

60656722

-
In-frameENST00000560397ENST00000451270CHP1chr15

41523647

+ANXA2chr15

60656722

-
intron-3CDSENST00000558351ENST00000332680CHP1chr15

41523647

+ANXA2chr15

60656722

-
intron-3CDSENST00000558351ENST00000396024CHP1chr15

41523647

+ANXA2chr15

60656722

-
intron-3CDSENST00000558351ENST00000421017CHP1chr15

41523647

+ANXA2chr15

60656722

-
intron-3CDSENST00000558351ENST00000451270CHP1chr15

41523647

+ANXA2chr15

60656722

-
intron-5UTRENST00000558351ENST00000557937CHP1chr15

41523647

+ANXA2chr15

60656722

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000334660CHP1chr1541523647+ENST00000396024ANXA2chr1560656722-1675307631178371
ENST00000334660CHP1chr1541523647+ENST00000451270ANXA2chr1560656722-1482307631178371
ENST00000334660CHP1chr1541523647+ENST00000332680ANXA2chr1560656722-1477307631178371
ENST00000334660CHP1chr1541523647+ENST00000421017ANXA2chr1560656722-1467307631178371
ENST00000560397CHP1chr1541523647+ENST00000396024ANXA2chr1560656722-152515701028342
ENST00000560397CHP1chr1541523647+ENST00000451270ANXA2chr1560656722-133215701028342
ENST00000560397CHP1chr1541523647+ENST00000332680ANXA2chr1560656722-132715701028342
ENST00000560397CHP1chr1541523647+ENST00000421017ANXA2chr1560656722-131715701028342

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000334660ENST00000396024CHP1chr1541523647+ANXA2chr1560656722-0.00207710.99792296
ENST00000334660ENST00000451270CHP1chr1541523647+ANXA2chr1560656722-0.0022534810.9977465
ENST00000334660ENST00000332680CHP1chr1541523647+ANXA2chr1560656722-0.0023286350.9976713
ENST00000334660ENST00000421017CHP1chr1541523647+ANXA2chr1560656722-0.0023669670.997633
ENST00000560397ENST00000396024CHP1chr1541523647+ANXA2chr1560656722-0.0017748570.99822515
ENST00000560397ENST00000451270CHP1chr1541523647+ANXA2chr1560656722-0.001704740.99829525
ENST00000560397ENST00000332680CHP1chr1541523647+ANXA2chr1560656722-0.0017852170.99821484
ENST00000560397ENST00000421017CHP1chr1541523647+ANXA2chr1560656722-0.001813630.9981864

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Fusion Genomic Features for CHP1-ANXA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CHP1-ANXA2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:41523647/chr15:60656722)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANXA2chr15:41523647chr15:60656722ENST00000332680213105_17667358.0RepeatAnnexin 2
TgeneANXA2chr15:41523647chr15:60656722ENST00000332680213189_26167358.0RepeatAnnexin 3
TgeneANXA2chr15:41523647chr15:60656722ENST00000332680213265_33667358.0RepeatAnnexin 4
TgeneANXA2chr15:41523647chr15:60656722ENST00000396024314105_17649340.0RepeatAnnexin 2
TgeneANXA2chr15:41523647chr15:60656722ENST00000396024314189_26149340.0RepeatAnnexin 3
TgeneANXA2chr15:41523647chr15:60656722ENST00000396024314265_33649340.0RepeatAnnexin 4
TgeneANXA2chr15:41523647chr15:60656722ENST00000421017314105_17649340.0RepeatAnnexin 2
TgeneANXA2chr15:41523647chr15:60656722ENST00000421017314189_26149340.0RepeatAnnexin 3
TgeneANXA2chr15:41523647chr15:60656722ENST00000421017314265_33649340.0RepeatAnnexin 4
TgeneANXA2chr15:41523647chr15:60656722ENST00000451270213105_17649340.0RepeatAnnexin 2
TgeneANXA2chr15:41523647chr15:60656722ENST00000451270213189_26149340.0RepeatAnnexin 3
TgeneANXA2chr15:41523647chr15:60656722ENST00000451270213265_33649340.0RepeatAnnexin 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHP1chr15:41523647chr15:60656722ENST00000334660+17123_13422196.0Calcium bindingNote=1
HgeneCHP1chr15:41523647chr15:60656722ENST00000334660+17164_17522196.0Calcium bindingNote=2
HgeneCHP1chr15:41523647chr15:60656722ENST00000334660+17110_14522196.0DomainEF-hand 3
HgeneCHP1chr15:41523647chr15:60656722ENST00000334660+17151_18622196.0DomainEF-hand 4
HgeneCHP1chr15:41523647chr15:60656722ENST00000334660+1726_6122196.0DomainEF-hand 1
HgeneCHP1chr15:41523647chr15:60656722ENST00000334660+1766_10122196.0DomainEF-hand 2
HgeneCHP1chr15:41523647chr15:60656722ENST00000334660+17138_14722196.0MotifNuclear export signal 1
HgeneCHP1chr15:41523647chr15:60656722ENST00000334660+17176_18522196.0MotifNuclear export signal 2
HgeneCHP1chr15:41523647chr15:60656722ENST00000334660+17143_18522196.0RegionNote=Necessary for nuclear export signal
TgeneANXA2chr15:41523647chr15:60656722ENST000003326802132_2467358.0RegionS100A10-binding site
TgeneANXA2chr15:41523647chr15:60656722ENST000003960243142_2449340.0RegionS100A10-binding site
TgeneANXA2chr15:41523647chr15:60656722ENST000004210173142_2449340.0RegionS100A10-binding site
TgeneANXA2chr15:41523647chr15:60656722ENST000004512702132_2449340.0RegionS100A10-binding site
TgeneANXA2chr15:41523647chr15:60656722ENST0000033268021333_10467358.0RepeatAnnexin 1
TgeneANXA2chr15:41523647chr15:60656722ENST0000039602431433_10449340.0RepeatAnnexin 1
TgeneANXA2chr15:41523647chr15:60656722ENST0000042101731433_10449340.0RepeatAnnexin 1
TgeneANXA2chr15:41523647chr15:60656722ENST0000045127021333_10449340.0RepeatAnnexin 1


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Fusion Gene Sequence for CHP1-ANXA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16602_16602_1_CHP1-ANXA2_CHP1_chr15_41523647_ENST00000334660_ANXA2_chr15_60656722_ENST00000332680_length(transcript)=1477nt_BP=307nt
CATTCGGGGCTGGAACTCGAACGCTGACGTTGGCTCCTGAGCCGGGCGCTGCCTCGCGCCTGATTGGCGGGTCCTCGGGGCCGCCCTCCC
CAGCGCACCACCCCTGGGTTCCCTCCCGGGTCCGCAGTGGAAACACTGCCCTCTCCCTTCTTGACCCCTAGCCCTTCCTTCCCTCCCTCC
TTCCCTCCTGTCGCCGTCTCTTCTGGCGCCGCTGCTCCCGGAGGAGCTCCCGGCACGGCGATGGGTTCTCGGGCCTCCACGTTACTGCGG
GACGAAGAGCTCGAGGAGATCAAGAAGGAGACCGGCTGTGTGGATGAGGTCACCATTGTCAACATTTTGACCAACCGCAGCAATGCACAG
AGACAGGATATTGCCTTCGCCTACCAGAGAAGGACCAAAAAGGAACTTGCATCAGCACTGAAGTCAGCCTTATCTGGCCACCTGGAGACG
GTGATTTTGGGCCTATTGAAGACACCTGCTCAGTATGACGCTTCTGAGCTAAAAGCTTCCATGAAGGGGCTGGGAACCGACGAGGACTCT
CTCATTGAGATCATCTGCTCCAGAACCAACCAGGAGCTGCAGGAAATTAACAGAGTCTACAAGGAAATGTACAAGACTGATCTGGAGAAG
GACATTATTTCGGACACATCTGGTGACTTCCGCAAGCTGATGGTTGCCCTGGCAAAGGGTAGAAGAGCAGAGGATGGCTCTGTCATTGAT
TATGAACTGATTGACCAAGATGCTCGGGATCTCTATGACGCTGGAGTGAAGAGGAAAGGAACTGATGTTCCCAAGTGGATCAGCATCATG
ACCGAGCGGAGCGTGCCCCACCTCCAGAAAGTATTTGATAGGTACAAGAGTTACAGCCCTTATGACATGTTGGAAAGCATCAGGAAAGAG
GTTAAAGGAGACCTGGAAAATGCTTTCCTGAACCTGGTTCAGTGCATTCAGAACAAGCCCCTGTATTTTGCTGATCGGCTGTATGACTCC
ATGAAGGGCAAGGGGACGCGAGATAAGGTCCTGATCAGAATCATGGTCTCCCGCAGTGAAGTGGACATGTTGAAAATTAGGTCTGAATTC
AAGAGAAAGTACGGCAAGTCCCTGTACTATTATATCCAGCAAGACACTAAGGGCGACTACCAGAAAGCGCTGCTGTACCTGTGTGGTGGA
GATGACTGAAGCCCGACACGGCCTGAGCGTCCAGAAATGGTGCTCACCATGCTTCCAGCTAACAGGTCTAGAAAACCAGCTTGCGAATAA
CAGTCCCCGTGGCCATCCCTGTGAGGGTGACGTTAGCATTACCCCCAACCTCATTTTAGTTGCCTAAGCATTGCCTGGCCTTCCTGTCTA
GTCTCTCCTGTAAGCCAAAGAAATGAACATTCCAAGGAGTTGGAAGTGAAGTCTATGATGTGAAACACTTTGCCTCCTGTGTACTGTGTC

>16602_16602_1_CHP1-ANXA2_CHP1_chr15_41523647_ENST00000334660_ANXA2_chr15_60656722_ENST00000332680_length(amino acids)=371AA_BP=82
MAGPRGRPPQRTTPGFPPGSAVETLPSPFLTPSPSFPPSFPPVAVSSGAAAPGGAPGTAMGSRASTLLRDEELEEIKKETGCVDEVTIVN
ILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYK
EMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPY
DMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQ

--------------------------------------------------------------
>16602_16602_2_CHP1-ANXA2_CHP1_chr15_41523647_ENST00000334660_ANXA2_chr15_60656722_ENST00000396024_length(transcript)=1675nt_BP=307nt
CATTCGGGGCTGGAACTCGAACGCTGACGTTGGCTCCTGAGCCGGGCGCTGCCTCGCGCCTGATTGGCGGGTCCTCGGGGCCGCCCTCCC
CAGCGCACCACCCCTGGGTTCCCTCCCGGGTCCGCAGTGGAAACACTGCCCTCTCCCTTCTTGACCCCTAGCCCTTCCTTCCCTCCCTCC
TTCCCTCCTGTCGCCGTCTCTTCTGGCGCCGCTGCTCCCGGAGGAGCTCCCGGCACGGCGATGGGTTCTCGGGCCTCCACGTTACTGCGG
GACGAAGAGCTCGAGGAGATCAAGAAGGAGACCGGCTGTGTGGATGAGGTCACCATTGTCAACATTTTGACCAACCGCAGCAATGCACAG
AGACAGGATATTGCCTTCGCCTACCAGAGAAGGACCAAAAAGGAACTTGCATCAGCACTGAAGTCAGCCTTATCTGGCCACCTGGAGACG
GTGATTTTGGGCCTATTGAAGACACCTGCTCAGTATGACGCTTCTGAGCTAAAAGCTTCCATGAAGGGGCTGGGAACCGACGAGGACTCT
CTCATTGAGATCATCTGCTCCAGAACCAACCAGGAGCTGCAGGAAATTAACAGAGTCTACAAGGAAATGTACAAGACTGATCTGGAGAAG
GACATTATTTCGGACACATCTGGTGACTTCCGCAAGCTGATGGTTGCCCTGGCAAAGGGTAGAAGAGCAGAGGATGGCTCTGTCATTGAT
TATGAACTGATTGACCAAGATGCTCGGGATCTCTATGACGCTGGAGTGAAGAGGAAAGGAACTGATGTTCCCAAGTGGATCAGCATCATG
ACCGAGCGGAGCGTGCCCCACCTCCAGAAAGTATTTGATAGGTACAAGAGTTACAGCCCTTATGACATGTTGGAAAGCATCAGGAAAGAG
GTTAAAGGAGACCTGGAAAATGCTTTCCTGAACCTGGTTCAGTGCATTCAGAACAAGCCCCTGTATTTTGCTGATCGGCTGTATGACTCC
ATGAAGGGCAAGGGGACGCGAGATAAGGTCCTGATCAGAATCATGGTCTCCCGCAGTGAAGTGGACATGTTGAAAATTAGGTCTGAATTC
AAGAGAAAGTACGGCAAGTCCCTGTACTATTATATCCAGCAAGACACTAAGGGCGACTACCAGAAAGCGCTGCTGTACCTGTGTGGTGGA
GATGACTGAAGCCCGACACGGCCTGAGCGTCCAGAAATGGTGCTCACCATGCTTCCAGCTAACAGGTCTAGAAAACCAGCTTGCGAATAA
CAGTCCCCGTGGCCATCCCTGTGAGGGTGACGTTAGCATTACCCCCAACCTCATTTTAGTTGCCTAAGCATTGCCTGGCCTTCCTGTCTA
GTCTCTCCTGTAAGCCAAAGAAATGAACATTCCAAGGAGTTGGAAGTGAAGTCTATGATGTGAAACACTTTGCCTCCTGTGTACTGTGTC
ATAAACAGATGAATAAACTGAATTTGTACTTTAGAAACACGTACTTTGTGGCCCTGCTTTCAACTGAATTGTTTGAAAATTAAACGTGCT
TGGGGTTCAGCTGGTGAGGCTGTCCCTGTAGGAAGAAAGCTCTGGGACTGAGCTGTACAGTATGGTTGCCCCTATCCAAGTGTCGCTATT

>16602_16602_2_CHP1-ANXA2_CHP1_chr15_41523647_ENST00000334660_ANXA2_chr15_60656722_ENST00000396024_length(amino acids)=371AA_BP=82
MAGPRGRPPQRTTPGFPPGSAVETLPSPFLTPSPSFPPSFPPVAVSSGAAAPGGAPGTAMGSRASTLLRDEELEEIKKETGCVDEVTIVN
ILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYK
EMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPY
DMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQ

--------------------------------------------------------------
>16602_16602_3_CHP1-ANXA2_CHP1_chr15_41523647_ENST00000334660_ANXA2_chr15_60656722_ENST00000421017_length(transcript)=1467nt_BP=307nt
CATTCGGGGCTGGAACTCGAACGCTGACGTTGGCTCCTGAGCCGGGCGCTGCCTCGCGCCTGATTGGCGGGTCCTCGGGGCCGCCCTCCC
CAGCGCACCACCCCTGGGTTCCCTCCCGGGTCCGCAGTGGAAACACTGCCCTCTCCCTTCTTGACCCCTAGCCCTTCCTTCCCTCCCTCC
TTCCCTCCTGTCGCCGTCTCTTCTGGCGCCGCTGCTCCCGGAGGAGCTCCCGGCACGGCGATGGGTTCTCGGGCCTCCACGTTACTGCGG
GACGAAGAGCTCGAGGAGATCAAGAAGGAGACCGGCTGTGTGGATGAGGTCACCATTGTCAACATTTTGACCAACCGCAGCAATGCACAG
AGACAGGATATTGCCTTCGCCTACCAGAGAAGGACCAAAAAGGAACTTGCATCAGCACTGAAGTCAGCCTTATCTGGCCACCTGGAGACG
GTGATTTTGGGCCTATTGAAGACACCTGCTCAGTATGACGCTTCTGAGCTAAAAGCTTCCATGAAGGGGCTGGGAACCGACGAGGACTCT
CTCATTGAGATCATCTGCTCCAGAACCAACCAGGAGCTGCAGGAAATTAACAGAGTCTACAAGGAAATGTACAAGACTGATCTGGAGAAG
GACATTATTTCGGACACATCTGGTGACTTCCGCAAGCTGATGGTTGCCCTGGCAAAGGGTAGAAGAGCAGAGGATGGCTCTGTCATTGAT
TATGAACTGATTGACCAAGATGCTCGGGATCTCTATGACGCTGGAGTGAAGAGGAAAGGAACTGATGTTCCCAAGTGGATCAGCATCATG
ACCGAGCGGAGCGTGCCCCACCTCCAGAAAGTATTTGATAGGTACAAGAGTTACAGCCCTTATGACATGTTGGAAAGCATCAGGAAAGAG
GTTAAAGGAGACCTGGAAAATGCTTTCCTGAACCTGGTTCAGTGCATTCAGAACAAGCCCCTGTATTTTGCTGATCGGCTGTATGACTCC
ATGAAGGGCAAGGGGACGCGAGATAAGGTCCTGATCAGAATCATGGTCTCCCGCAGTGAAGTGGACATGTTGAAAATTAGGTCTGAATTC
AAGAGAAAGTACGGCAAGTCCCTGTACTATTATATCCAGCAAGACACTAAGGGCGACTACCAGAAAGCGCTGCTGTACCTGTGTGGTGGA
GATGACTGAAGCCCGACACGGCCTGAGCGTCCAGAAATGGTGCTCACCATGCTTCCAGCTAACAGGTCTAGAAAACCAGCTTGCGAATAA
CAGTCCCCGTGGCCATCCCTGTGAGGGTGACGTTAGCATTACCCCCAACCTCATTTTAGTTGCCTAAGCATTGCCTGGCCTTCCTGTCTA
GTCTCTCCTGTAAGCCAAAGAAATGAACATTCCAAGGAGTTGGAAGTGAAGTCTATGATGTGAAACACTTTGCCTCCTGTGTACTGTGTC

>16602_16602_3_CHP1-ANXA2_CHP1_chr15_41523647_ENST00000334660_ANXA2_chr15_60656722_ENST00000421017_length(amino acids)=371AA_BP=82
MAGPRGRPPQRTTPGFPPGSAVETLPSPFLTPSPSFPPSFPPVAVSSGAAAPGGAPGTAMGSRASTLLRDEELEEIKKETGCVDEVTIVN
ILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYK
EMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPY
DMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQ

--------------------------------------------------------------
>16602_16602_4_CHP1-ANXA2_CHP1_chr15_41523647_ENST00000334660_ANXA2_chr15_60656722_ENST00000451270_length(transcript)=1482nt_BP=307nt
CATTCGGGGCTGGAACTCGAACGCTGACGTTGGCTCCTGAGCCGGGCGCTGCCTCGCGCCTGATTGGCGGGTCCTCGGGGCCGCCCTCCC
CAGCGCACCACCCCTGGGTTCCCTCCCGGGTCCGCAGTGGAAACACTGCCCTCTCCCTTCTTGACCCCTAGCCCTTCCTTCCCTCCCTCC
TTCCCTCCTGTCGCCGTCTCTTCTGGCGCCGCTGCTCCCGGAGGAGCTCCCGGCACGGCGATGGGTTCTCGGGCCTCCACGTTACTGCGG
GACGAAGAGCTCGAGGAGATCAAGAAGGAGACCGGCTGTGTGGATGAGGTCACCATTGTCAACATTTTGACCAACCGCAGCAATGCACAG
AGACAGGATATTGCCTTCGCCTACCAGAGAAGGACCAAAAAGGAACTTGCATCAGCACTGAAGTCAGCCTTATCTGGCCACCTGGAGACG
GTGATTTTGGGCCTATTGAAGACACCTGCTCAGTATGACGCTTCTGAGCTAAAAGCTTCCATGAAGGGGCTGGGAACCGACGAGGACTCT
CTCATTGAGATCATCTGCTCCAGAACCAACCAGGAGCTGCAGGAAATTAACAGAGTCTACAAGGAAATGTACAAGACTGATCTGGAGAAG
GACATTATTTCGGACACATCTGGTGACTTCCGCAAGCTGATGGTTGCCCTGGCAAAGGGTAGAAGAGCAGAGGATGGCTCTGTCATTGAT
TATGAACTGATTGACCAAGATGCTCGGGATCTCTATGACGCTGGAGTGAAGAGGAAAGGAACTGATGTTCCCAAGTGGATCAGCATCATG
ACCGAGCGGAGCGTGCCCCACCTCCAGAAAGTATTTGATAGGTACAAGAGTTACAGCCCTTATGACATGTTGGAAAGCATCAGGAAAGAG
GTTAAAGGAGACCTGGAAAATGCTTTCCTGAACCTGGTTCAGTGCATTCAGAACAAGCCCCTGTATTTTGCTGATCGGCTGTATGACTCC
ATGAAGGGCAAGGGGACGCGAGATAAGGTCCTGATCAGAATCATGGTCTCCCGCAGTGAAGTGGACATGTTGAAAATTAGGTCTGAATTC
AAGAGAAAGTACGGCAAGTCCCTGTACTATTATATCCAGCAAGACACTAAGGGCGACTACCAGAAAGCGCTGCTGTACCTGTGTGGTGGA
GATGACTGAAGCCCGACACGGCCTGAGCGTCCAGAAATGGTGCTCACCATGCTTCCAGCTAACAGGTCTAGAAAACCAGCTTGCGAATAA
CAGTCCCCGTGGCCATCCCTGTGAGGGTGACGTTAGCATTACCCCCAACCTCATTTTAGTTGCCTAAGCATTGCCTGGCCTTCCTGTCTA
GTCTCTCCTGTAAGCCAAAGAAATGAACATTCCAAGGAGTTGGAAGTGAAGTCTATGATGTGAAACACTTTGCCTCCTGTGTACTGTGTC

>16602_16602_4_CHP1-ANXA2_CHP1_chr15_41523647_ENST00000334660_ANXA2_chr15_60656722_ENST00000451270_length(amino acids)=371AA_BP=82
MAGPRGRPPQRTTPGFPPGSAVETLPSPFLTPSPSFPPSFPPVAVSSGAAAPGGAPGTAMGSRASTLLRDEELEEIKKETGCVDEVTIVN
ILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYK
EMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPY
DMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQ

--------------------------------------------------------------
>16602_16602_5_CHP1-ANXA2_CHP1_chr15_41523647_ENST00000560397_ANXA2_chr15_60656722_ENST00000332680_length(transcript)=1327nt_BP=157nt
TTGACCCCTAGCCCTTCCTTCCCTCCCTCCTTCCCTCCTGTCGCCGTCTCTTCTGGCGCCGCTGCTCCCGGAGGAGCTCCCGGCACGGCG
ATGGGTTCTCGGGCCTCCACGTTACTGCGGGACGAAGAGCTCGAGGAGATCAAGAAGGAGACCGGCTGTGTGGATGAGGTCACCATTGTC
AACATTTTGACCAACCGCAGCAATGCACAGAGACAGGATATTGCCTTCGCCTACCAGAGAAGGACCAAAAAGGAACTTGCATCAGCACTG
AAGTCAGCCTTATCTGGCCACCTGGAGACGGTGATTTTGGGCCTATTGAAGACACCTGCTCAGTATGACGCTTCTGAGCTAAAAGCTTCC
ATGAAGGGGCTGGGAACCGACGAGGACTCTCTCATTGAGATCATCTGCTCCAGAACCAACCAGGAGCTGCAGGAAATTAACAGAGTCTAC
AAGGAAATGTACAAGACTGATCTGGAGAAGGACATTATTTCGGACACATCTGGTGACTTCCGCAAGCTGATGGTTGCCCTGGCAAAGGGT
AGAAGAGCAGAGGATGGCTCTGTCATTGATTATGAACTGATTGACCAAGATGCTCGGGATCTCTATGACGCTGGAGTGAAGAGGAAAGGA
ACTGATGTTCCCAAGTGGATCAGCATCATGACCGAGCGGAGCGTGCCCCACCTCCAGAAAGTATTTGATAGGTACAAGAGTTACAGCCCT
TATGACATGTTGGAAAGCATCAGGAAAGAGGTTAAAGGAGACCTGGAAAATGCTTTCCTGAACCTGGTTCAGTGCATTCAGAACAAGCCC
CTGTATTTTGCTGATCGGCTGTATGACTCCATGAAGGGCAAGGGGACGCGAGATAAGGTCCTGATCAGAATCATGGTCTCCCGCAGTGAA
GTGGACATGTTGAAAATTAGGTCTGAATTCAAGAGAAAGTACGGCAAGTCCCTGTACTATTATATCCAGCAAGACACTAAGGGCGACTAC
CAGAAAGCGCTGCTGTACCTGTGTGGTGGAGATGACTGAAGCCCGACACGGCCTGAGCGTCCAGAAATGGTGCTCACCATGCTTCCAGCT
AACAGGTCTAGAAAACCAGCTTGCGAATAACAGTCCCCGTGGCCATCCCTGTGAGGGTGACGTTAGCATTACCCCCAACCTCATTTTAGT
TGCCTAAGCATTGCCTGGCCTTCCTGTCTAGTCTCTCCTGTAAGCCAAAGAAATGAACATTCCAAGGAGTTGGAAGTGAAGTCTATGATG

>16602_16602_5_CHP1-ANXA2_CHP1_chr15_41523647_ENST00000560397_ANXA2_chr15_60656722_ENST00000332680_length(amino acids)=342AA_BP=53
LTPSPSFPPSFPPVAVSSGAAAPGGAPGTAMGSRASTLLRDEELEEIKKETGCVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASAL
KSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKG
RRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKP

--------------------------------------------------------------
>16602_16602_6_CHP1-ANXA2_CHP1_chr15_41523647_ENST00000560397_ANXA2_chr15_60656722_ENST00000396024_length(transcript)=1525nt_BP=157nt
TTGACCCCTAGCCCTTCCTTCCCTCCCTCCTTCCCTCCTGTCGCCGTCTCTTCTGGCGCCGCTGCTCCCGGAGGAGCTCCCGGCACGGCG
ATGGGTTCTCGGGCCTCCACGTTACTGCGGGACGAAGAGCTCGAGGAGATCAAGAAGGAGACCGGCTGTGTGGATGAGGTCACCATTGTC
AACATTTTGACCAACCGCAGCAATGCACAGAGACAGGATATTGCCTTCGCCTACCAGAGAAGGACCAAAAAGGAACTTGCATCAGCACTG
AAGTCAGCCTTATCTGGCCACCTGGAGACGGTGATTTTGGGCCTATTGAAGACACCTGCTCAGTATGACGCTTCTGAGCTAAAAGCTTCC
ATGAAGGGGCTGGGAACCGACGAGGACTCTCTCATTGAGATCATCTGCTCCAGAACCAACCAGGAGCTGCAGGAAATTAACAGAGTCTAC
AAGGAAATGTACAAGACTGATCTGGAGAAGGACATTATTTCGGACACATCTGGTGACTTCCGCAAGCTGATGGTTGCCCTGGCAAAGGGT
AGAAGAGCAGAGGATGGCTCTGTCATTGATTATGAACTGATTGACCAAGATGCTCGGGATCTCTATGACGCTGGAGTGAAGAGGAAAGGA
ACTGATGTTCCCAAGTGGATCAGCATCATGACCGAGCGGAGCGTGCCCCACCTCCAGAAAGTATTTGATAGGTACAAGAGTTACAGCCCT
TATGACATGTTGGAAAGCATCAGGAAAGAGGTTAAAGGAGACCTGGAAAATGCTTTCCTGAACCTGGTTCAGTGCATTCAGAACAAGCCC
CTGTATTTTGCTGATCGGCTGTATGACTCCATGAAGGGCAAGGGGACGCGAGATAAGGTCCTGATCAGAATCATGGTCTCCCGCAGTGAA
GTGGACATGTTGAAAATTAGGTCTGAATTCAAGAGAAAGTACGGCAAGTCCCTGTACTATTATATCCAGCAAGACACTAAGGGCGACTAC
CAGAAAGCGCTGCTGTACCTGTGTGGTGGAGATGACTGAAGCCCGACACGGCCTGAGCGTCCAGAAATGGTGCTCACCATGCTTCCAGCT
AACAGGTCTAGAAAACCAGCTTGCGAATAACAGTCCCCGTGGCCATCCCTGTGAGGGTGACGTTAGCATTACCCCCAACCTCATTTTAGT
TGCCTAAGCATTGCCTGGCCTTCCTGTCTAGTCTCTCCTGTAAGCCAAAGAAATGAACATTCCAAGGAGTTGGAAGTGAAGTCTATGATG
TGAAACACTTTGCCTCCTGTGTACTGTGTCATAAACAGATGAATAAACTGAATTTGTACTTTAGAAACACGTACTTTGTGGCCCTGCTTT
CAACTGAATTGTTTGAAAATTAAACGTGCTTGGGGTTCAGCTGGTGAGGCTGTCCCTGTAGGAAGAAAGCTCTGGGACTGAGCTGTACAG

>16602_16602_6_CHP1-ANXA2_CHP1_chr15_41523647_ENST00000560397_ANXA2_chr15_60656722_ENST00000396024_length(amino acids)=342AA_BP=53
LTPSPSFPPSFPPVAVSSGAAAPGGAPGTAMGSRASTLLRDEELEEIKKETGCVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASAL
KSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKG
RRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKP

--------------------------------------------------------------
>16602_16602_7_CHP1-ANXA2_CHP1_chr15_41523647_ENST00000560397_ANXA2_chr15_60656722_ENST00000421017_length(transcript)=1317nt_BP=157nt
TTGACCCCTAGCCCTTCCTTCCCTCCCTCCTTCCCTCCTGTCGCCGTCTCTTCTGGCGCCGCTGCTCCCGGAGGAGCTCCCGGCACGGCG
ATGGGTTCTCGGGCCTCCACGTTACTGCGGGACGAAGAGCTCGAGGAGATCAAGAAGGAGACCGGCTGTGTGGATGAGGTCACCATTGTC
AACATTTTGACCAACCGCAGCAATGCACAGAGACAGGATATTGCCTTCGCCTACCAGAGAAGGACCAAAAAGGAACTTGCATCAGCACTG
AAGTCAGCCTTATCTGGCCACCTGGAGACGGTGATTTTGGGCCTATTGAAGACACCTGCTCAGTATGACGCTTCTGAGCTAAAAGCTTCC
ATGAAGGGGCTGGGAACCGACGAGGACTCTCTCATTGAGATCATCTGCTCCAGAACCAACCAGGAGCTGCAGGAAATTAACAGAGTCTAC
AAGGAAATGTACAAGACTGATCTGGAGAAGGACATTATTTCGGACACATCTGGTGACTTCCGCAAGCTGATGGTTGCCCTGGCAAAGGGT
AGAAGAGCAGAGGATGGCTCTGTCATTGATTATGAACTGATTGACCAAGATGCTCGGGATCTCTATGACGCTGGAGTGAAGAGGAAAGGA
ACTGATGTTCCCAAGTGGATCAGCATCATGACCGAGCGGAGCGTGCCCCACCTCCAGAAAGTATTTGATAGGTACAAGAGTTACAGCCCT
TATGACATGTTGGAAAGCATCAGGAAAGAGGTTAAAGGAGACCTGGAAAATGCTTTCCTGAACCTGGTTCAGTGCATTCAGAACAAGCCC
CTGTATTTTGCTGATCGGCTGTATGACTCCATGAAGGGCAAGGGGACGCGAGATAAGGTCCTGATCAGAATCATGGTCTCCCGCAGTGAA
GTGGACATGTTGAAAATTAGGTCTGAATTCAAGAGAAAGTACGGCAAGTCCCTGTACTATTATATCCAGCAAGACACTAAGGGCGACTAC
CAGAAAGCGCTGCTGTACCTGTGTGGTGGAGATGACTGAAGCCCGACACGGCCTGAGCGTCCAGAAATGGTGCTCACCATGCTTCCAGCT
AACAGGTCTAGAAAACCAGCTTGCGAATAACAGTCCCCGTGGCCATCCCTGTGAGGGTGACGTTAGCATTACCCCCAACCTCATTTTAGT
TGCCTAAGCATTGCCTGGCCTTCCTGTCTAGTCTCTCCTGTAAGCCAAAGAAATGAACATTCCAAGGAGTTGGAAGTGAAGTCTATGATG

>16602_16602_7_CHP1-ANXA2_CHP1_chr15_41523647_ENST00000560397_ANXA2_chr15_60656722_ENST00000421017_length(amino acids)=342AA_BP=53
LTPSPSFPPSFPPVAVSSGAAAPGGAPGTAMGSRASTLLRDEELEEIKKETGCVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASAL
KSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKG
RRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKP

--------------------------------------------------------------
>16602_16602_8_CHP1-ANXA2_CHP1_chr15_41523647_ENST00000560397_ANXA2_chr15_60656722_ENST00000451270_length(transcript)=1332nt_BP=157nt
TTGACCCCTAGCCCTTCCTTCCCTCCCTCCTTCCCTCCTGTCGCCGTCTCTTCTGGCGCCGCTGCTCCCGGAGGAGCTCCCGGCACGGCG
ATGGGTTCTCGGGCCTCCACGTTACTGCGGGACGAAGAGCTCGAGGAGATCAAGAAGGAGACCGGCTGTGTGGATGAGGTCACCATTGTC
AACATTTTGACCAACCGCAGCAATGCACAGAGACAGGATATTGCCTTCGCCTACCAGAGAAGGACCAAAAAGGAACTTGCATCAGCACTG
AAGTCAGCCTTATCTGGCCACCTGGAGACGGTGATTTTGGGCCTATTGAAGACACCTGCTCAGTATGACGCTTCTGAGCTAAAAGCTTCC
ATGAAGGGGCTGGGAACCGACGAGGACTCTCTCATTGAGATCATCTGCTCCAGAACCAACCAGGAGCTGCAGGAAATTAACAGAGTCTAC
AAGGAAATGTACAAGACTGATCTGGAGAAGGACATTATTTCGGACACATCTGGTGACTTCCGCAAGCTGATGGTTGCCCTGGCAAAGGGT
AGAAGAGCAGAGGATGGCTCTGTCATTGATTATGAACTGATTGACCAAGATGCTCGGGATCTCTATGACGCTGGAGTGAAGAGGAAAGGA
ACTGATGTTCCCAAGTGGATCAGCATCATGACCGAGCGGAGCGTGCCCCACCTCCAGAAAGTATTTGATAGGTACAAGAGTTACAGCCCT
TATGACATGTTGGAAAGCATCAGGAAAGAGGTTAAAGGAGACCTGGAAAATGCTTTCCTGAACCTGGTTCAGTGCATTCAGAACAAGCCC
CTGTATTTTGCTGATCGGCTGTATGACTCCATGAAGGGCAAGGGGACGCGAGATAAGGTCCTGATCAGAATCATGGTCTCCCGCAGTGAA
GTGGACATGTTGAAAATTAGGTCTGAATTCAAGAGAAAGTACGGCAAGTCCCTGTACTATTATATCCAGCAAGACACTAAGGGCGACTAC
CAGAAAGCGCTGCTGTACCTGTGTGGTGGAGATGACTGAAGCCCGACACGGCCTGAGCGTCCAGAAATGGTGCTCACCATGCTTCCAGCT
AACAGGTCTAGAAAACCAGCTTGCGAATAACAGTCCCCGTGGCCATCCCTGTGAGGGTGACGTTAGCATTACCCCCAACCTCATTTTAGT
TGCCTAAGCATTGCCTGGCCTTCCTGTCTAGTCTCTCCTGTAAGCCAAAGAAATGAACATTCCAAGGAGTTGGAAGTGAAGTCTATGATG

>16602_16602_8_CHP1-ANXA2_CHP1_chr15_41523647_ENST00000560397_ANXA2_chr15_60656722_ENST00000451270_length(amino acids)=342AA_BP=53
LTPSPSFPPSFPPVAVSSGAAAPGGAPGTAMGSRASTLLRDEELEEIKKETGCVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASAL
KSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKG
RRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CHP1-ANXA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHP1-ANXA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHP1-ANXA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0001787Osteoporosis, Age-Related1CTD_human
TgeneC0007137Squamous cell carcinoma1CTD_human
TgeneC0019193Hepatitis, Toxic1CTD_human
TgeneC0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0023903Liver neoplasms1CTD_human
TgeneC0024121Lung Neoplasms1CTD_human
TgeneC0024667Animal Mammary Neoplasms1CTD_human
TgeneC0026640Mouth Neoplasms1CTD_human
TgeneC0026998Acute Myeloid Leukemia, M11CTD_human
TgeneC0027626Neoplasm Invasiveness1CTD_human
TgeneC0029456Osteoporosis1CTD_human
TgeneC0029459Osteoporosis, Senile1CTD_human
TgeneC0043094Weight Gain1CTD_human
TgeneC0153381Malignant neoplasm of mouth1CTD_human
TgeneC0242379Malignant neoplasm of lung1CTD_human
TgeneC0345904Malignant neoplasm of liver1CTD_human
TgeneC0345967Malignant mesothelioma1CTD_human
TgeneC0751406Post-Traumatic Osteoporosis1CTD_human
TgeneC0860207Drug-Induced Liver Disease1CTD_human
TgeneC1257925Mammary Carcinoma, Animal1CTD_human
TgeneC1262760Hepatitis, Drug-Induced1CTD_human
TgeneC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
TgeneC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneC4279912Chemically-Induced Liver Toxicity1CTD_human