Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KLHL2-STK24 (FusionGDB2 ID:HG11275TG8428)

Fusion Gene Summary for KLHL2-STK24

Fusion gene summary

Fusion gene information	Fusion gene name: KLHL2-STK24
	Fusion gene ID: hg11275tg8428
		Hgene	Tgene
	Gene symbol	KLHL2	STK24
	Gene ID	11275	8428
	Gene name	kelch like family member 2	serine/threonine kinase 24
	Synonyms	ABP-KELCH\|MAV\|MAYVEN	HEL-S-95\|MST3\|MST3B\|STE20\|STK3
	Cytomap	('KLHL2')('STK24') 4q32.3	13q32.2
	Type of gene	protein-coding	protein-coding
	Description	kelch-like protein 2actin-binding protein Mayvenkelch-like 2, Mayven	serine/threonine-protein kinase 24STE20-like kinase 3STE20-like kinase MST3epididymis secretory protein Li 95mammalian STE20-like protein kinase 3serine/threonine kinase 24 (STE20 homolog, yeast)sterile 20-like kinase 3
	Modification date	20200327	20200313
	UniProtAcc	O95198	.
	Ensembl transtripts involved in fusion gene	ENST00000226725, ENST00000514860, ENST00000538127, ENST00000421009, ENST00000506761, ENST00000509028,
Fusion gene scores	* DoF score	7 X 5 X 5=175	15 X 8 X 8=960
	# samples	9	18
	** MAII score	log2(9/175*10)=-0.959358015502654 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/960*10)=-2.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KLHL2 [Title/Abstract] AND STK24 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KLHL2(166160051)-STK24(99171727), # samples:1
Anticipated loss of major functional domain due to fusion event.	KLHL2-STK24 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KLHL2-STK24 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KLHL2-STK24 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KLHL2-STK24 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	STK24	GO:0006468	protein phosphorylation	19604147
Tgene	STK24	GO:0042542	response to hydrogen peroxide	22291017
Tgene	STK24	GO:0046777	protein autophosphorylation	17046825\|17657516

Fusion gene breakpoints across KLHL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across STK24 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8058-01A	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-

Top

Fusion Gene ORF analysis for KLHL2-STK24

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000226725	ENST00000376547	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-
5CDS-5UTR	ENST00000226725	ENST00000481288	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-
5CDS-5UTR	ENST00000514860	ENST00000376547	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-
5CDS-5UTR	ENST00000514860	ENST00000481288	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-
5CDS-5UTR	ENST00000538127	ENST00000376547	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-
5CDS-5UTR	ENST00000538127	ENST00000481288	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-
In-frame	ENST00000226725	ENST00000397517	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-
In-frame	ENST00000226725	ENST00000539966	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-
In-frame	ENST00000514860	ENST00000397517	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-
In-frame	ENST00000514860	ENST00000539966	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-
In-frame	ENST00000538127	ENST00000397517	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-
In-frame	ENST00000538127	ENST00000539966	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-
intron-3CDS	ENST00000421009	ENST00000397517	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-
intron-3CDS	ENST00000421009	ENST00000539966	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-
intron-3CDS	ENST00000506761	ENST00000397517	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-
intron-3CDS	ENST00000506761	ENST00000539966	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-
intron-3CDS	ENST00000509028	ENST00000397517	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-
intron-3CDS	ENST00000509028	ENST00000539966	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-
intron-5UTR	ENST00000421009	ENST00000376547	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-
intron-5UTR	ENST00000421009	ENST00000481288	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-
intron-5UTR	ENST00000506761	ENST00000376547	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-
intron-5UTR	ENST00000506761	ENST00000481288	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-
intron-5UTR	ENST00000509028	ENST00000376547	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-
intron-5UTR	ENST00000509028	ENST00000481288	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000226725	KLHL2	chr4	166160051	+	ENST00000397517	STK24	chr13	99171727	-	4866	640	259	1893	544
ENST00000226725	KLHL2	chr4	166160051	+	ENST00000539966	STK24	chr13	99171727	-	2095	640	259	1836	525
ENST00000514860	KLHL2	chr4	166160051	+	ENST00000397517	STK24	chr13	99171727	-	4869	643	205	1896	563
ENST00000514860	KLHL2	chr4	166160051	+	ENST00000539966	STK24	chr13	99171727	-	2098	643	205	1839	544
ENST00000538127	KLHL2	chr4	166160051	+	ENST00000397517	STK24	chr13	99171727	-	4636	410	293	1663	456
ENST00000538127	KLHL2	chr4	166160051	+	ENST00000539966	STK24	chr13	99171727	-	1865	410	293	1606	437

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000226725	ENST00000397517	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-	0.000591155	0.99940884
ENST00000226725	ENST00000539966	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-	0.00257091	0.9974291
ENST00000514860	ENST00000397517	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-	0.00040687	0.9995932
ENST00000514860	ENST00000539966	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-	0.001902365	0.9980976
ENST00000538127	ENST00000397517	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-	0.000408748	0.9995913
ENST00000538127	ENST00000539966	KLHL2	chr4	166160051	+	STK24	chr13	99171727	-	0.002319556	0.9976804

Top

Fusion Genomic Features for KLHL2-STK24

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Top

Fusion Protein Features for KLHL2-STK24

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:166160051/chr13:99171727)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KLHL2 O95198	.
FUNCTION: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors. {ECO:0000250, ECO:0000269\|PubMed:15715669, ECO:0000269\|PubMed:23838290}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KLHL2

chr4:166160051

chr13:99171727

ENST00000226725

56_123

127

594.0

Domain

BTB

Hgene

KLHL2

chr4:166160051

chr13:99171727

ENST00000514860

56_123

131

598.0

Domain

BTB

Tgene

STK24

chr4:166160051

chr13:99171727

ENST00000376547

36_286

444.0

Domain

Protein kinase

Tgene

STK24

chr4:166160051

chr13:99171727

ENST00000397517

36_286

432.0

Domain

Protein kinase

Tgene

STK24

chr4:166160051

chr13:99171727

ENST00000376547

278_292

444.0

Motif

Note=Bipartite nuclear localization signal

Tgene

STK24

chr4:166160051

chr13:99171727

ENST00000376547

335_386

444.0

Motif

Note=Nuclear export signal (NES)

Tgene

STK24

chr4:166160051

chr13:99171727

ENST00000397517

278_292

432.0

Motif

Note=Bipartite nuclear localization signal

Tgene

STK24

chr4:166160051

chr13:99171727

ENST00000397517

335_386

432.0

Motif

Note=Nuclear export signal (NES)

Tgene

STK24

chr4:166160051

chr13:99171727

ENST00000376547

112_114

444.0

Nucleotide binding

Note=ATP

Tgene

STK24

chr4:166160051

chr13:99171727

ENST00000376547

42_50

444.0

Nucleotide binding

Note=ATP

Tgene

STK24

chr4:166160051

chr13:99171727

ENST00000397517

112_114

432.0

Nucleotide binding

Note=ATP

Tgene

STK24

chr4:166160051

chr13:99171727

ENST00000397517

42_50

432.0

Nucleotide binding

Note=ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KLHL2

chr4:166160051

chr13:99171727

ENST00000538127

56_123

506.0

Domain

BTB

Hgene

KLHL2

chr4:166160051

chr13:99171727

ENST00000226725

308_353

127

594.0

Repeat

Note=Kelch 1

Hgene

KLHL2

chr4:166160051

chr13:99171727

ENST00000226725

354_400

127

594.0

Repeat

Note=Kelch 2

Hgene

KLHL2

chr4:166160051

chr13:99171727

ENST00000226725

402_447

127

594.0

Repeat

Note=Kelch 3

Hgene

KLHL2

chr4:166160051

chr13:99171727

ENST00000226725

449_496

127

594.0

Repeat

Note=Kelch 4

Hgene

KLHL2

chr4:166160051

chr13:99171727

ENST00000226725

497_543

127

594.0

Repeat

Note=Kelch 5

Hgene

KLHL2

chr4:166160051

chr13:99171727

ENST00000226725

545_591

127

594.0

Repeat

Note=Kelch 6

Hgene

KLHL2

chr4:166160051

chr13:99171727

ENST00000514860

308_353

131

598.0

Repeat

Note=Kelch 1

Hgene

KLHL2

chr4:166160051

chr13:99171727

ENST00000514860

354_400

131

598.0

Repeat

Note=Kelch 2

Hgene

KLHL2

chr4:166160051

chr13:99171727

ENST00000514860

402_447

131

598.0

Repeat

Note=Kelch 3

Hgene

KLHL2

chr4:166160051

chr13:99171727

ENST00000514860

449_496

131

598.0

Repeat

Note=Kelch 4

Hgene

KLHL2

chr4:166160051

chr13:99171727

ENST00000514860

497_543

131

598.0

Repeat

Note=Kelch 5

Hgene

KLHL2

chr4:166160051

chr13:99171727

ENST00000514860

545_591

131

598.0

Repeat

Note=Kelch 6

Hgene

KLHL2

chr4:166160051

chr13:99171727

ENST00000538127

308_353

506.0

Repeat

Note=Kelch 1

Hgene

KLHL2

chr4:166160051

chr13:99171727

ENST00000538127

354_400

506.0

Repeat

Note=Kelch 2

Hgene

KLHL2

chr4:166160051

chr13:99171727

ENST00000538127

402_447

506.0

Repeat

Note=Kelch 3

Hgene

KLHL2

chr4:166160051

chr13:99171727

ENST00000538127

449_496

506.0

Repeat

Note=Kelch 4

Hgene

KLHL2

chr4:166160051

chr13:99171727

ENST00000538127

497_543

506.0

Repeat

Note=Kelch 5

Hgene

KLHL2

chr4:166160051

chr13:99171727

ENST00000538127

545_591

506.0

Repeat

Note=Kelch 6

Top

Fusion Gene Sequence for KLHL2-STK24

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>43007_43007_1_KLHL2-STK24_KLHL2_chr4_166160051_ENST00000226725_STK24_chr13_99171727_ENST00000397517_length(transcript)=4866nt_BP=640nt
GCGCCCGCCGGTCCCGTCGCCGCCGCCCCGCACTCGGGCGAGCGCGGGAGCCGCGCAGTAGACGGAGCGCGCCCGGCCGAGCGGGCCATG
GCCGCGGGGGCCGCCGCCGCAGGTGGTGGCGCGCGGTGAGGAGAGCGCGGCGCCCCCTCCGGGGCGGATGGAACGCGGCTCGGCGGGCGG
GCAGTGCCGGCGTCCGCGGCTGGAATGGTGCTGGCTGTGTTGGTCGGTGCCTGCGTTCTGAAGCCCGAGAGGAGCCACAATGGAGACGCC
GCCGCTGCCTCCCGCATGCACAAAGCAGGGTCATCAGAAGCCTCTCGATTCAAAAGATGATAATACCGAAAAACACTGCCCAGTGACAGT
GAATCCTTGGCATATGAAGAAAGCTTTCAAAGTCATGAACGAATTAAGAAGTCAAAATTTGCTGTGCGATGTCACAATTGTGGCAGAAGA
CATGGAAATTTCTGCTCATAGAGTGGTGCTGGCCGCCTGTAGTCCTTATTTTCATGCCATGTTTACAGGTGAGATGAGTGAGAGCCGAGC
AAAGAGAGTTAGAATAAAAGAGGTAGATGGCTGGACCCTGAGGATGCTAATTGATTATGTTTACACTGCAGAAATTCAGGTTACAGAAGA
AAATGTACAGAACCTAAAGGCAGACCCAGAAGAGCTTTTTACAAAACTAGAGAAAATTGGGAAGGGCTCCTTTGGAGAGGTGTTCAAAGG
CATTGACAATCGGACTCAGAAAGTGGTTGCCATAAAGATCATTGATCTGGAAGAAGCTGAAGATGAGATAGAGGACATTCAACAAGAAAT
CACAGTGCTGAGTCAGTGTGACAGTCCATATGTAACCAAATATTATGGATCCTATCTGAAGGATACAAAATTATGGATAATAATGGAATA
TCTTGGTGGAGGCTCCGCACTAGATCTATTAGAACCTGGCCCATTAGATGAAACCCAGATCGCTACTATATTAAGAGAAATACTGAAAGG
ACTCGATTATCTCCATTCGGAGAAGAAAATCCACAGAGACATTAAAGCGGCCAACGTCCTGCTGTCTGAGCATGGCGAGGTGAAGCTGGC
GGACTTTGGCGTGGCTGGCCAGCTGACAGACACCCAGATCAAAAGGAACACCTTCGTGGGCACCCCATTCTGGATGGCACCCGAGGTCAT
CAAACAGTCGGCCTATGACTCGAAGGCAGACATCTGGTCCCTGGGCATAACAGCTATTGAACTTGCAAGAGGGGAACCACCTCATTCCGA
GCTGCACCCCATGAAAGTTTTATTCCTCATTCCAAAGAACAACCCACCGACGTTGGAAGGAAACTACAGTAAACCCCTCAAGGAGTTTGT
GGAGGCCTGTTTGAATAAGGAGCCGAGCTTTAGACCCACTGCTAAGGAGTTATTGAAGCACAAGTTTATACTACGCAATGCAAAGAAAAC
TTCCTACTTGACCGAGCTCATCGACAGGTACAAGAGATGGAAGGCCGAGCAGAGCCATGACGACTCGAGCTCCGAGGATTCCGACGCGGA
AACAGATGGCCAAGCCTCGGGGGGCAGTGATTCTGGGGACTGGATCTTCACAATCCGAGAAAAAGATCCCAAGAATCTCGAGAATGGAGC
TCTTCAGCCATCGGACTTGGACAGAAATAAGATGAAAGACATCCCGAAGAGGCCTTTCTCTCAGTGTTTATCTACAATTATTTCTCCTCT
GTTTGCAGAGTTGAAGGAGAAGAGCCAGGCGTGCGGAGGGAACTTGGGGTCCATTGAAGAGCTGCGAGGGGCCATCTACCTAGCGGAGGA
GGCGTGCCCTGGCATCTCCGACACCATGGTGGCCCAGCTCGTGCAGCGGCTCCAGAGATACTCTCTAAGTGGTGGAGGAACTTCATCCCA
CTGAAATTCCTTTGGCATTTGGGGTTTTGTTTTTCCTTTTTTCCTTCTTCATCCTCCTCCTTTTTTAAAAGTCAACGAGAGCCTTCGCTG
ACTCCACCGAAGAGGTGCGCCACTGGGAGCCACCCCAGCGCCAGGCGCCCGTCCAGGGACACACACAGTCTTCACTGTGCTGCAGCCAGA
TGAAGTCTCTCAGATGGGTGGGGAGGGTCAGCTCCTTCCAGCGATCATTTTATTTTATTTTATTACTTTTGTTTTTAATTTTAACCATAG
TGCACATATTCCAGGAAAGTGTCTTTAAAAACAAAAACAAACCCTGAAATGTATATTTGGGATTATGATAAGGCAACTAAAGACATGAAA
CCTCAGGTATCCTGCTTTAAGTTGATAACTCCCTCTGGGAGCTGGAGAATCGCTCTGGTGGATGGGTGTACAGATTTGTATATAATGTCA
TTTTTACGGAAACCCTTTCGGCGTGCATAAGGAATCACTGTGTACAAACTGGCCAAGTGCTTCTGTAGATAACGTCAGTGGAGTAAATAT
TCGACAGGCCATAACTTGAGTCTATTGCCTTGCCTTTATTACATGTACATTTTGAATTCTGTGACCAGTGATTTGGGTTTTATTTTGTAT
TTGCAGGGTTTGTCATTAATAATTAATGCCCCTCTCTTACAGAACACTCCTATTTGTACCTCAACAAATGCAAATTTTCCCCGTTTGCCC
TACGCCCCTTTTGGTACACCTAGAGGTTGATTTCCTTTTTCATCGATGGTACTATTTCTTAGTGTTTTAAATTGGAACATATCTTGCCTC
ATGAAGCTTTAAATTATAATTTTCAGTTTCTCCCCATGAAGCGCTCTCGTCTGACATTTGTTTGGAATCGTGCCACTGCTGGTCTGCGCC
AGATGTACCGTCCTTTCCAATACGATTTTCTGTTGCACCTTGTAGTGGATTCTGCATATCATCTTTCCCACCTAAAAATGTCTGAATGCT
TACACAAATAAATTTTATAACACGCTTATTTTGCATACTCCTTGAAATGTGACTCTTCAGAGGACAGGGCACCTGCTGTGTATGTGTGGC
CGTGCGTGTGTACTCGTGGCTGTGTGTGTGTGATGAGACACTTTGGAAGACTCCAGGGAGAAGTCCCCAGGCCTGGAGCTGCCGAGTGCC
CAGGTCAGCGCCCTGGACTGCTTGCGCACTTGCTCACCGAGATGATGCAGTTGGAGGTTGCTGATCTGTGCGATTGCTGTAGCGGTTGCC
GGGGACCTTAAGAGTTATTTTGCTTCTCTGGAAGGGGCCTATGCTTGCTAGGCAGGCAGCCAGTGTGTCTGTTTTTCTTGGTTTGCTGTG
GGACCTTGCTTGGCGAGGGGGAAAATCTCTGGGTTTCTGGAGTGGGAGGGTTCGTGCAGCAGCTGTTGACTGGTACATGAAGCATTCTTT
TATGTTTGTTGAAGCTGATGATTGACATCTCCCGTGGGTGTGCCAGTTCTTGTGGAGTTAAGACAGGATTTTTGGAAGCAAGGAAGTTAG
TGGGTGAGCTTGGGGATGTAGCTCAGCTATCTGCTGGTCTAGTGGCCTCTAAGCTATAGGGAGGGGACAGAGCCCTGAGCTACAGATGCT
TGAGTGGGTTATTGTGTCGGTTTGCTAGTGCAGTCTGGTTTTTAAGCTCTAAAATTGAGGTATTTTATTAGAAGTGGATTTGGGTTGAAC
TCTTAATTTGTATAAGGGATATATTTTGGTTGGGGAAATAGAACTGAGTTGCTAATTCTTATTGTACTCATTACTCCATACAAGAATGTT
ATGTTGAATAATAAAATTGGAGAAGATTTCATTTTGTGTTTCCAGGGAGTATTCTGTGTGGGGAACTGTTTCCTTACGTGAGGCCGGCGG
CATAAGTCAAAGATGAGTTTTGTCCTTGCGAATCACACAGATTGAGTCTGTGTTCCCCAGGGTGTGCCGTTACCTGATTTTTAAGTGAGC
CAGGGCGGACAGCAGCTTTTCTGATTTACAGAGTTCTTCAGATTTACAAATGGACAATGACATCACAGTTTTTAGCACTGAAGCCAGTCT
CATGCTAGTAACAGTGGGTGAGCCGCTCGAGGGACTGGGTTCTAATGAATACTGGTATGAACGGGGAGTCTCTGCAGTCGCCAGACAAAT
CATACTCAGCCCCTTCCCCCGTAGAGCAACAAGTGGTTCTTTTAGAGTTGACTGGCAGCATTTCCTGTCGGGGGAGGTGGGGTTTGATGG
AGTTAGAAAGCTCGCCTCTGTGTACATTCTCTCCTGGGCTGTTACTTTCTGTAGACGCACAAAATCAGCCCCAATGTTTTTAAGGGCATC
TTAGCCAAGGAAGCTGGCTTTTGTGTCGCCACTTCCAGGCCTGCATTAAGAGAGAGCCCAGGCACCAGGGCTACCACTGGAACCTGCCTC
AGCGTCAACTGCTGCTGGTCTGTAGCCAGGCCCAGCCTTTGAGACGGGTTTACTGTCACCAGTAGCCTCTCAGTGCCAGCCCTGAGCTGC
TCCTGGCTCAGCTGCCCAGAGCCTGCAGCCTGGGGAGGTACTCAGCCTCTGGGAGACGAGGGCCGTGGACTGGGTGGCTGGTAGCTCCTG
CGTTTTTGAGCTGTGTCCTGGCTGGCTGCTGCCAATGAGGTGGACACCAGTGTGGTTTGGGGTGCACTGGCCACTTCTTGCTGGGTTCTG
ATTTTCTTGGAAGTGCATCTGCCTTCCTTATCCAATAGTTTTATCCCTGCATTGCTCTTGTGAAGTGGCTGGTTTGGTTCTGTATGTAGC
ATTTTGTACCTTTCCTCTGGCAAAACACTGTCAGTTTATAAACATTTTTTATATTTCCCTCCTTTAAAAACAGCTTGTGTATTTCTGCTA
TAAAATGTGTCAGCAAAGGCAGAGTGACCTAATAGGGCATGTTCTTAAGCACAGGGACTGTATCATGCAGGGGCCAATAAAGCTCAAGAA

>43007_43007_1_KLHL2-STK24_KLHL2_chr4_166160051_ENST00000226725_STK24_chr13_99171727_ENST00000397517_length(amino acids)=544AA_BP=126
METPPLPPACTKQGHQKPLDSKDDNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMS
ESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDI
QQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGE
VKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPL
KEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNL
ENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRLQRYSLSGGG

--------------------------------------------------------------
>43007_43007_2_KLHL2-STK24_KLHL2_chr4_166160051_ENST00000226725_STK24_chr13_99171727_ENST00000539966_length(transcript)=2095nt_BP=640nt
GCGCCCGCCGGTCCCGTCGCCGCCGCCCCGCACTCGGGCGAGCGCGGGAGCCGCGCAGTAGACGGAGCGCGCCCGGCCGAGCGGGCCATG
GCCGCGGGGGCCGCCGCCGCAGGTGGTGGCGCGCGGTGAGGAGAGCGCGGCGCCCCCTCCGGGGCGGATGGAACGCGGCTCGGCGGGCGG
GCAGTGCCGGCGTCCGCGGCTGGAATGGTGCTGGCTGTGTTGGTCGGTGCCTGCGTTCTGAAGCCCGAGAGGAGCCACAATGGAGACGCC
GCCGCTGCCTCCCGCATGCACAAAGCAGGGTCATCAGAAGCCTCTCGATTCAAAAGATGATAATACCGAAAAACACTGCCCAGTGACAGT
GAATCCTTGGCATATGAAGAAAGCTTTCAAAGTCATGAACGAATTAAGAAGTCAAAATTTGCTGTGCGATGTCACAATTGTGGCAGAAGA
CATGGAAATTTCTGCTCATAGAGTGGTGCTGGCCGCCTGTAGTCCTTATTTTCATGCCATGTTTACAGGTGAGATGAGTGAGAGCCGAGC
AAAGAGAGTTAGAATAAAAGAGGTAGATGGCTGGACCCTGAGGATGCTAATTGATTATGTTTACACTGCAGAAATTCAGGTTACAGAAGA
AAATGTACAGAACCTAAAGGCAGACCCAGAAGAGCTTTTTACAAAACTAGAGAAAATTGGGAAGGGCTCCTTTGGAGAGGTGTTCAAAGG
CATTGACAATCGGACTCAGAAAGTGGTTGCCATAAAGATCATTGATCTGGAAGAAGCTGAAGATGAGATAGAGGACATTCAACAAGAAAT
CACAGTGCTGAGTCAGTGTGACAGTCCATATGTAACCAAATATTATGGATCCTATCTGAAGTTAGAACCTGGCCCATTAGATGAAACCCA
GATCGCTACTATATTAAGAGAAATACTGAAAGGACTCGATTATCTCCATTCGGAGAAGAAAATCCACAGAGACATTAAAGCGGCCAACGT
CCTGCTGTCTGAGCATGGCGAGGTGAAGCTGGCGGACTTTGGCGTGGCTGGCCAGCTGACAGACACCCAGATCAAAAGGAACACCTTCGT
GGGCACCCCATTCTGGATGGCACCCGAGGTCATCAAACAGTCGGCCTATGACTCGAAGGCAGACATCTGGTCCCTGGGCATAACAGCTAT
TGAACTTGCAAGAGGGGAACCACCTCATTCCGAGCTGCACCCCATGAAAGTTTTATTCCTCATTCCAAAGAACAACCCACCGACGTTGGA
AGGAAACTACAGTAAACCCCTCAAGGAGTTTGTGGAGGCCTGTTTGAATAAGGAGCCGAGCTTTAGACCCACTGCTAAGGAGTTATTGAA
GCACAAGTTTATACTACGCAATGCAAAGAAAACTTCCTACTTGACCGAGCTCATCGACAGGTACAAGAGATGGAAGGCCGAGCAGAGCCA
TGACGACTCGAGCTCCGAGGATTCCGACGCGGAAACAGATGGCCAAGCCTCGGGGGGCAGTGATTCTGGGGACTGGATCTTCACAATCCG
AGAAAAAGATCCCAAGAATCTCGAGAATGGAGCTCTTCAGCCATCGGACTTGGACAGAAATAAGATGAAAGACATCCCGAAGAGGCCTTT
CTCTCAGTGTTTATCTACAATTATTTCTCCTCTGTTTGCAGAGTTGAAGGAGAAGAGCCAGGCGTGCGGAGGGAACTTGGGGTCCATTGA
AGAGCTGCGAGGGGCCATCTACCTAGCGGAGGAGGCGTGCCCTGGCATCTCCGACACCATGGTGGCCCAGCTCGTGCAGCGGCTCCAGAG
ATACTCTCTAAGTGGTGGAGGAACTTCATCCCACTGAAATTCCTTTGGCATTTGGGGTTTTGTTTTTCCTTTTTTCCTTCTTCATCCTCC
TCCTTTTTTAAAAGTCAACGAGAGCCTTCGCTGACTCCACCGAAGAGGTGCGCCACTGGGAGCCACCCCAGCGCCAGGCGCCCGTCCAGG
GACACACACAGTCTTCACTGTGCTGCAGCCAGATGAAGTCTCTCAGATGGGTGGGGAGGGTCAGCTCCTTCCAGCGATCATTTTATTTTA

>43007_43007_2_KLHL2-STK24_KLHL2_chr4_166160051_ENST00000226725_STK24_chr13_99171727_ENST00000539966_length(amino acids)=525AA_BP=126
METPPLPPACTKQGHQKPLDSKDDNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMS
ESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDI
QQEITVLSQCDSPYVTKYYGSYLKLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKR
NTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAK
ELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIP

--------------------------------------------------------------
>43007_43007_3_KLHL2-STK24_KLHL2_chr4_166160051_ENST00000514860_STK24_chr13_99171727_ENST00000397517_length(transcript)=4869nt_BP=643nt
TTTTTTTCCTTGCCACCCCTTGGCCTGTTTGCCTCCACTCCCATTAACATCCCTCCACCATGGATCCCGTGTGCCGGATTTGAGACTTGC
AGGCAGTGTCTTTAGGAAGGAACTTTACCGGGCCTCACTGCCAGAGCTGGGCTAGAACAGAGGCCAGTGGAAACTATTAGGAAGACTCAG
CTTTTCATGAAGTTAGATTTTTAGCCTGAGCTTTAAGTCAAAGAAAGATGACCTGGACTTAAAGTGCCTTATGGTATGGTTGGAAGCACG
GCCCCAGATTCTCTTTGTATGCACAAAGCAGGGTCATCAGAAGCCTCTCGATTCAAAAGATGATAATACCGAAAAACACTGCCCAGTGAC
AGTGAATCCTTGGCATATGAAGAAAGCTTTCAAAGTCATGAACGAATTAAGAAGTCAAAATTTGCTGTGCGATGTCACAATTGTGGCAGA
AGACATGGAAATTTCTGCTCATAGAGTGGTGCTGGCCGCCTGTAGTCCTTATTTTCATGCCATGTTTACAGGTGAGATGAGTGAGAGCCG
AGCAAAGAGAGTTAGAATAAAAGAGGTAGATGGCTGGACCCTGAGGATGCTAATTGATTATGTTTACACTGCAGAAATTCAGGTTACAGA
AGAAAATGTACAGAACCTAAAGGCAGACCCAGAAGAGCTTTTTACAAAACTAGAGAAAATTGGGAAGGGCTCCTTTGGAGAGGTGTTCAA
AGGCATTGACAATCGGACTCAGAAAGTGGTTGCCATAAAGATCATTGATCTGGAAGAAGCTGAAGATGAGATAGAGGACATTCAACAAGA
AATCACAGTGCTGAGTCAGTGTGACAGTCCATATGTAACCAAATATTATGGATCCTATCTGAAGGATACAAAATTATGGATAATAATGGA
ATATCTTGGTGGAGGCTCCGCACTAGATCTATTAGAACCTGGCCCATTAGATGAAACCCAGATCGCTACTATATTAAGAGAAATACTGAA
AGGACTCGATTATCTCCATTCGGAGAAGAAAATCCACAGAGACATTAAAGCGGCCAACGTCCTGCTGTCTGAGCATGGCGAGGTGAAGCT
GGCGGACTTTGGCGTGGCTGGCCAGCTGACAGACACCCAGATCAAAAGGAACACCTTCGTGGGCACCCCATTCTGGATGGCACCCGAGGT
CATCAAACAGTCGGCCTATGACTCGAAGGCAGACATCTGGTCCCTGGGCATAACAGCTATTGAACTTGCAAGAGGGGAACCACCTCATTC
CGAGCTGCACCCCATGAAAGTTTTATTCCTCATTCCAAAGAACAACCCACCGACGTTGGAAGGAAACTACAGTAAACCCCTCAAGGAGTT
TGTGGAGGCCTGTTTGAATAAGGAGCCGAGCTTTAGACCCACTGCTAAGGAGTTATTGAAGCACAAGTTTATACTACGCAATGCAAAGAA
AACTTCCTACTTGACCGAGCTCATCGACAGGTACAAGAGATGGAAGGCCGAGCAGAGCCATGACGACTCGAGCTCCGAGGATTCCGACGC
GGAAACAGATGGCCAAGCCTCGGGGGGCAGTGATTCTGGGGACTGGATCTTCACAATCCGAGAAAAAGATCCCAAGAATCTCGAGAATGG
AGCTCTTCAGCCATCGGACTTGGACAGAAATAAGATGAAAGACATCCCGAAGAGGCCTTTCTCTCAGTGTTTATCTACAATTATTTCTCC
TCTGTTTGCAGAGTTGAAGGAGAAGAGCCAGGCGTGCGGAGGGAACTTGGGGTCCATTGAAGAGCTGCGAGGGGCCATCTACCTAGCGGA
GGAGGCGTGCCCTGGCATCTCCGACACCATGGTGGCCCAGCTCGTGCAGCGGCTCCAGAGATACTCTCTAAGTGGTGGAGGAACTTCATC
CCACTGAAATTCCTTTGGCATTTGGGGTTTTGTTTTTCCTTTTTTCCTTCTTCATCCTCCTCCTTTTTTAAAAGTCAACGAGAGCCTTCG
CTGACTCCACCGAAGAGGTGCGCCACTGGGAGCCACCCCAGCGCCAGGCGCCCGTCCAGGGACACACACAGTCTTCACTGTGCTGCAGCC
AGATGAAGTCTCTCAGATGGGTGGGGAGGGTCAGCTCCTTCCAGCGATCATTTTATTTTATTTTATTACTTTTGTTTTTAATTTTAACCA
TAGTGCACATATTCCAGGAAAGTGTCTTTAAAAACAAAAACAAACCCTGAAATGTATATTTGGGATTATGATAAGGCAACTAAAGACATG
AAACCTCAGGTATCCTGCTTTAAGTTGATAACTCCCTCTGGGAGCTGGAGAATCGCTCTGGTGGATGGGTGTACAGATTTGTATATAATG
TCATTTTTACGGAAACCCTTTCGGCGTGCATAAGGAATCACTGTGTACAAACTGGCCAAGTGCTTCTGTAGATAACGTCAGTGGAGTAAA
TATTCGACAGGCCATAACTTGAGTCTATTGCCTTGCCTTTATTACATGTACATTTTGAATTCTGTGACCAGTGATTTGGGTTTTATTTTG
TATTTGCAGGGTTTGTCATTAATAATTAATGCCCCTCTCTTACAGAACACTCCTATTTGTACCTCAACAAATGCAAATTTTCCCCGTTTG
CCCTACGCCCCTTTTGGTACACCTAGAGGTTGATTTCCTTTTTCATCGATGGTACTATTTCTTAGTGTTTTAAATTGGAACATATCTTGC
CTCATGAAGCTTTAAATTATAATTTTCAGTTTCTCCCCATGAAGCGCTCTCGTCTGACATTTGTTTGGAATCGTGCCACTGCTGGTCTGC
GCCAGATGTACCGTCCTTTCCAATACGATTTTCTGTTGCACCTTGTAGTGGATTCTGCATATCATCTTTCCCACCTAAAAATGTCTGAAT
GCTTACACAAATAAATTTTATAACACGCTTATTTTGCATACTCCTTGAAATGTGACTCTTCAGAGGACAGGGCACCTGCTGTGTATGTGT
GGCCGTGCGTGTGTACTCGTGGCTGTGTGTGTGTGATGAGACACTTTGGAAGACTCCAGGGAGAAGTCCCCAGGCCTGGAGCTGCCGAGT
GCCCAGGTCAGCGCCCTGGACTGCTTGCGCACTTGCTCACCGAGATGATGCAGTTGGAGGTTGCTGATCTGTGCGATTGCTGTAGCGGTT
GCCGGGGACCTTAAGAGTTATTTTGCTTCTCTGGAAGGGGCCTATGCTTGCTAGGCAGGCAGCCAGTGTGTCTGTTTTTCTTGGTTTGCT
GTGGGACCTTGCTTGGCGAGGGGGAAAATCTCTGGGTTTCTGGAGTGGGAGGGTTCGTGCAGCAGCTGTTGACTGGTACATGAAGCATTC
TTTTATGTTTGTTGAAGCTGATGATTGACATCTCCCGTGGGTGTGCCAGTTCTTGTGGAGTTAAGACAGGATTTTTGGAAGCAAGGAAGT
TAGTGGGTGAGCTTGGGGATGTAGCTCAGCTATCTGCTGGTCTAGTGGCCTCTAAGCTATAGGGAGGGGACAGAGCCCTGAGCTACAGAT
GCTTGAGTGGGTTATTGTGTCGGTTTGCTAGTGCAGTCTGGTTTTTAAGCTCTAAAATTGAGGTATTTTATTAGAAGTGGATTTGGGTTG
AACTCTTAATTTGTATAAGGGATATATTTTGGTTGGGGAAATAGAACTGAGTTGCTAATTCTTATTGTACTCATTACTCCATACAAGAAT
GTTATGTTGAATAATAAAATTGGAGAAGATTTCATTTTGTGTTTCCAGGGAGTATTCTGTGTGGGGAACTGTTTCCTTACGTGAGGCCGG
CGGCATAAGTCAAAGATGAGTTTTGTCCTTGCGAATCACACAGATTGAGTCTGTGTTCCCCAGGGTGTGCCGTTACCTGATTTTTAAGTG
AGCCAGGGCGGACAGCAGCTTTTCTGATTTACAGAGTTCTTCAGATTTACAAATGGACAATGACATCACAGTTTTTAGCACTGAAGCCAG
TCTCATGCTAGTAACAGTGGGTGAGCCGCTCGAGGGACTGGGTTCTAATGAATACTGGTATGAACGGGGAGTCTCTGCAGTCGCCAGACA
AATCATACTCAGCCCCTTCCCCCGTAGAGCAACAAGTGGTTCTTTTAGAGTTGACTGGCAGCATTTCCTGTCGGGGGAGGTGGGGTTTGA
TGGAGTTAGAAAGCTCGCCTCTGTGTACATTCTCTCCTGGGCTGTTACTTTCTGTAGACGCACAAAATCAGCCCCAATGTTTTTAAGGGC
ATCTTAGCCAAGGAAGCTGGCTTTTGTGTCGCCACTTCCAGGCCTGCATTAAGAGAGAGCCCAGGCACCAGGGCTACCACTGGAACCTGC
CTCAGCGTCAACTGCTGCTGGTCTGTAGCCAGGCCCAGCCTTTGAGACGGGTTTACTGTCACCAGTAGCCTCTCAGTGCCAGCCCTGAGC
TGCTCCTGGCTCAGCTGCCCAGAGCCTGCAGCCTGGGGAGGTACTCAGCCTCTGGGAGACGAGGGCCGTGGACTGGGTGGCTGGTAGCTC
CTGCGTTTTTGAGCTGTGTCCTGGCTGGCTGCTGCCAATGAGGTGGACACCAGTGTGGTTTGGGGTGCACTGGCCACTTCTTGCTGGGTT
CTGATTTTCTTGGAAGTGCATCTGCCTTCCTTATCCAATAGTTTTATCCCTGCATTGCTCTTGTGAAGTGGCTGGTTTGGTTCTGTATGT
AGCATTTTGTACCTTTCCTCTGGCAAAACACTGTCAGTTTATAAACATTTTTTATATTTCCCTCCTTTAAAAACAGCTTGTGTATTTCTG
CTATAAAATGTGTCAGCAAAGGCAGAGTGACCTAATAGGGCATGTTCTTAAGCACAGGGACTGTATCATGCAGGGGCCAATAAAGCTCAA

>43007_43007_3_KLHL2-STK24_KLHL2_chr4_166160051_ENST00000514860_STK24_chr13_99171727_ENST00000397517_length(amino acids)=563AA_BP=145
MSFKSKKDDLDLKCLMVWLEARPQILFVCTKQGHQKPLDSKDDNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHR
VVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQK
VVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSE
KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVL
FLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASG
GSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISD

--------------------------------------------------------------
>43007_43007_4_KLHL2-STK24_KLHL2_chr4_166160051_ENST00000514860_STK24_chr13_99171727_ENST00000539966_length(transcript)=2098nt_BP=643nt
TTTTTTTCCTTGCCACCCCTTGGCCTGTTTGCCTCCACTCCCATTAACATCCCTCCACCATGGATCCCGTGTGCCGGATTTGAGACTTGC
AGGCAGTGTCTTTAGGAAGGAACTTTACCGGGCCTCACTGCCAGAGCTGGGCTAGAACAGAGGCCAGTGGAAACTATTAGGAAGACTCAG
CTTTTCATGAAGTTAGATTTTTAGCCTGAGCTTTAAGTCAAAGAAAGATGACCTGGACTTAAAGTGCCTTATGGTATGGTTGGAAGCACG
GCCCCAGATTCTCTTTGTATGCACAAAGCAGGGTCATCAGAAGCCTCTCGATTCAAAAGATGATAATACCGAAAAACACTGCCCAGTGAC
AGTGAATCCTTGGCATATGAAGAAAGCTTTCAAAGTCATGAACGAATTAAGAAGTCAAAATTTGCTGTGCGATGTCACAATTGTGGCAGA
AGACATGGAAATTTCTGCTCATAGAGTGGTGCTGGCCGCCTGTAGTCCTTATTTTCATGCCATGTTTACAGGTGAGATGAGTGAGAGCCG
AGCAAAGAGAGTTAGAATAAAAGAGGTAGATGGCTGGACCCTGAGGATGCTAATTGATTATGTTTACACTGCAGAAATTCAGGTTACAGA
AGAAAATGTACAGAACCTAAAGGCAGACCCAGAAGAGCTTTTTACAAAACTAGAGAAAATTGGGAAGGGCTCCTTTGGAGAGGTGTTCAA
AGGCATTGACAATCGGACTCAGAAAGTGGTTGCCATAAAGATCATTGATCTGGAAGAAGCTGAAGATGAGATAGAGGACATTCAACAAGA
AATCACAGTGCTGAGTCAGTGTGACAGTCCATATGTAACCAAATATTATGGATCCTATCTGAAGTTAGAACCTGGCCCATTAGATGAAAC
CCAGATCGCTACTATATTAAGAGAAATACTGAAAGGACTCGATTATCTCCATTCGGAGAAGAAAATCCACAGAGACATTAAAGCGGCCAA
CGTCCTGCTGTCTGAGCATGGCGAGGTGAAGCTGGCGGACTTTGGCGTGGCTGGCCAGCTGACAGACACCCAGATCAAAAGGAACACCTT
CGTGGGCACCCCATTCTGGATGGCACCCGAGGTCATCAAACAGTCGGCCTATGACTCGAAGGCAGACATCTGGTCCCTGGGCATAACAGC
TATTGAACTTGCAAGAGGGGAACCACCTCATTCCGAGCTGCACCCCATGAAAGTTTTATTCCTCATTCCAAAGAACAACCCACCGACGTT
GGAAGGAAACTACAGTAAACCCCTCAAGGAGTTTGTGGAGGCCTGTTTGAATAAGGAGCCGAGCTTTAGACCCACTGCTAAGGAGTTATT
GAAGCACAAGTTTATACTACGCAATGCAAAGAAAACTTCCTACTTGACCGAGCTCATCGACAGGTACAAGAGATGGAAGGCCGAGCAGAG
CCATGACGACTCGAGCTCCGAGGATTCCGACGCGGAAACAGATGGCCAAGCCTCGGGGGGCAGTGATTCTGGGGACTGGATCTTCACAAT
CCGAGAAAAAGATCCCAAGAATCTCGAGAATGGAGCTCTTCAGCCATCGGACTTGGACAGAAATAAGATGAAAGACATCCCGAAGAGGCC
TTTCTCTCAGTGTTTATCTACAATTATTTCTCCTCTGTTTGCAGAGTTGAAGGAGAAGAGCCAGGCGTGCGGAGGGAACTTGGGGTCCAT
TGAAGAGCTGCGAGGGGCCATCTACCTAGCGGAGGAGGCGTGCCCTGGCATCTCCGACACCATGGTGGCCCAGCTCGTGCAGCGGCTCCA
GAGATACTCTCTAAGTGGTGGAGGAACTTCATCCCACTGAAATTCCTTTGGCATTTGGGGTTTTGTTTTTCCTTTTTTCCTTCTTCATCC
TCCTCCTTTTTTAAAAGTCAACGAGAGCCTTCGCTGACTCCACCGAAGAGGTGCGCCACTGGGAGCCACCCCAGCGCCAGGCGCCCGTCC
AGGGACACACACAGTCTTCACTGTGCTGCAGCCAGATGAAGTCTCTCAGATGGGTGGGGAGGGTCAGCTCCTTCCAGCGATCATTTTATT

>43007_43007_4_KLHL2-STK24_KLHL2_chr4_166160051_ENST00000514860_STK24_chr13_99171727_ENST00000539966_length(amino acids)=544AA_BP=145
MSFKSKKDDLDLKCLMVWLEARPQILFVCTKQGHQKPLDSKDDNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHR
VVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQK
VVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGE
VKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPL
KEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNL
ENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRLQRYSLSGGG

--------------------------------------------------------------
>43007_43007_5_KLHL2-STK24_KLHL2_chr4_166160051_ENST00000538127_STK24_chr13_99171727_ENST00000397517_length(transcript)=4636nt_BP=410nt
ACTGCCAGAGCTGGGCTAGAACAGAGGCCAGTGGAAACTATTAGGAAGACTCAGCTTTTCATGAAGTTAGATTTTTAGCCTGAGCTTTAA
GTCAAAGAAAGATGACCTGGACTTAAAGTGCCTTATGGTATGGTTGGAAGCACGGCCCCAGATTCTCTTTGTATGCACAAAGCAGGGTCA
TCAGAAGCCTCTCGATTCAAAAGATGATAATACCGAAAAACACTGCCCAGTGACAGTGAATCCTTGGCATATGAAGAAAGCTTTCAAAGT
CATGAACGAATTAAGAAGGTGAGATGAGTGAGAGCCGAGCAAAGAGAGTTAGAATAAAAGAGGTAGATGGCTGGACCCTGAGGATGCTAA
TTGATTATGTTTACACTGCAGAAATTCAGGTTACAGAAGAAAATGTACAGAACCTAAAGGCAGACCCAGAAGAGCTTTTTACAAAACTAG
AGAAAATTGGGAAGGGCTCCTTTGGAGAGGTGTTCAAAGGCATTGACAATCGGACTCAGAAAGTGGTTGCCATAAAGATCATTGATCTGG
AAGAAGCTGAAGATGAGATAGAGGACATTCAACAAGAAATCACAGTGCTGAGTCAGTGTGACAGTCCATATGTAACCAAATATTATGGAT
CCTATCTGAAGGATACAAAATTATGGATAATAATGGAATATCTTGGTGGAGGCTCCGCACTAGATCTATTAGAACCTGGCCCATTAGATG
AAACCCAGATCGCTACTATATTAAGAGAAATACTGAAAGGACTCGATTATCTCCATTCGGAGAAGAAAATCCACAGAGACATTAAAGCGG
CCAACGTCCTGCTGTCTGAGCATGGCGAGGTGAAGCTGGCGGACTTTGGCGTGGCTGGCCAGCTGACAGACACCCAGATCAAAAGGAACA
CCTTCGTGGGCACCCCATTCTGGATGGCACCCGAGGTCATCAAACAGTCGGCCTATGACTCGAAGGCAGACATCTGGTCCCTGGGCATAA
CAGCTATTGAACTTGCAAGAGGGGAACCACCTCATTCCGAGCTGCACCCCATGAAAGTTTTATTCCTCATTCCAAAGAACAACCCACCGA
CGTTGGAAGGAAACTACAGTAAACCCCTCAAGGAGTTTGTGGAGGCCTGTTTGAATAAGGAGCCGAGCTTTAGACCCACTGCTAAGGAGT
TATTGAAGCACAAGTTTATACTACGCAATGCAAAGAAAACTTCCTACTTGACCGAGCTCATCGACAGGTACAAGAGATGGAAGGCCGAGC
AGAGCCATGACGACTCGAGCTCCGAGGATTCCGACGCGGAAACAGATGGCCAAGCCTCGGGGGGCAGTGATTCTGGGGACTGGATCTTCA
CAATCCGAGAAAAAGATCCCAAGAATCTCGAGAATGGAGCTCTTCAGCCATCGGACTTGGACAGAAATAAGATGAAAGACATCCCGAAGA
GGCCTTTCTCTCAGTGTTTATCTACAATTATTTCTCCTCTGTTTGCAGAGTTGAAGGAGAAGAGCCAGGCGTGCGGAGGGAACTTGGGGT
CCATTGAAGAGCTGCGAGGGGCCATCTACCTAGCGGAGGAGGCGTGCCCTGGCATCTCCGACACCATGGTGGCCCAGCTCGTGCAGCGGC
TCCAGAGATACTCTCTAAGTGGTGGAGGAACTTCATCCCACTGAAATTCCTTTGGCATTTGGGGTTTTGTTTTTCCTTTTTTCCTTCTTC
ATCCTCCTCCTTTTTTAAAAGTCAACGAGAGCCTTCGCTGACTCCACCGAAGAGGTGCGCCACTGGGAGCCACCCCAGCGCCAGGCGCCC
GTCCAGGGACACACACAGTCTTCACTGTGCTGCAGCCAGATGAAGTCTCTCAGATGGGTGGGGAGGGTCAGCTCCTTCCAGCGATCATTT
TATTTTATTTTATTACTTTTGTTTTTAATTTTAACCATAGTGCACATATTCCAGGAAAGTGTCTTTAAAAACAAAAACAAACCCTGAAAT
GTATATTTGGGATTATGATAAGGCAACTAAAGACATGAAACCTCAGGTATCCTGCTTTAAGTTGATAACTCCCTCTGGGAGCTGGAGAAT
CGCTCTGGTGGATGGGTGTACAGATTTGTATATAATGTCATTTTTACGGAAACCCTTTCGGCGTGCATAAGGAATCACTGTGTACAAACT
GGCCAAGTGCTTCTGTAGATAACGTCAGTGGAGTAAATATTCGACAGGCCATAACTTGAGTCTATTGCCTTGCCTTTATTACATGTACAT
TTTGAATTCTGTGACCAGTGATTTGGGTTTTATTTTGTATTTGCAGGGTTTGTCATTAATAATTAATGCCCCTCTCTTACAGAACACTCC
TATTTGTACCTCAACAAATGCAAATTTTCCCCGTTTGCCCTACGCCCCTTTTGGTACACCTAGAGGTTGATTTCCTTTTTCATCGATGGT
ACTATTTCTTAGTGTTTTAAATTGGAACATATCTTGCCTCATGAAGCTTTAAATTATAATTTTCAGTTTCTCCCCATGAAGCGCTCTCGT
CTGACATTTGTTTGGAATCGTGCCACTGCTGGTCTGCGCCAGATGTACCGTCCTTTCCAATACGATTTTCTGTTGCACCTTGTAGTGGAT
TCTGCATATCATCTTTCCCACCTAAAAATGTCTGAATGCTTACACAAATAAATTTTATAACACGCTTATTTTGCATACTCCTTGAAATGT
GACTCTTCAGAGGACAGGGCACCTGCTGTGTATGTGTGGCCGTGCGTGTGTACTCGTGGCTGTGTGTGTGTGATGAGACACTTTGGAAGA
CTCCAGGGAGAAGTCCCCAGGCCTGGAGCTGCCGAGTGCCCAGGTCAGCGCCCTGGACTGCTTGCGCACTTGCTCACCGAGATGATGCAG
TTGGAGGTTGCTGATCTGTGCGATTGCTGTAGCGGTTGCCGGGGACCTTAAGAGTTATTTTGCTTCTCTGGAAGGGGCCTATGCTTGCTA
GGCAGGCAGCCAGTGTGTCTGTTTTTCTTGGTTTGCTGTGGGACCTTGCTTGGCGAGGGGGAAAATCTCTGGGTTTCTGGAGTGGGAGGG
TTCGTGCAGCAGCTGTTGACTGGTACATGAAGCATTCTTTTATGTTTGTTGAAGCTGATGATTGACATCTCCCGTGGGTGTGCCAGTTCT
TGTGGAGTTAAGACAGGATTTTTGGAAGCAAGGAAGTTAGTGGGTGAGCTTGGGGATGTAGCTCAGCTATCTGCTGGTCTAGTGGCCTCT
AAGCTATAGGGAGGGGACAGAGCCCTGAGCTACAGATGCTTGAGTGGGTTATTGTGTCGGTTTGCTAGTGCAGTCTGGTTTTTAAGCTCT
AAAATTGAGGTATTTTATTAGAAGTGGATTTGGGTTGAACTCTTAATTTGTATAAGGGATATATTTTGGTTGGGGAAATAGAACTGAGTT
GCTAATTCTTATTGTACTCATTACTCCATACAAGAATGTTATGTTGAATAATAAAATTGGAGAAGATTTCATTTTGTGTTTCCAGGGAGT
ATTCTGTGTGGGGAACTGTTTCCTTACGTGAGGCCGGCGGCATAAGTCAAAGATGAGTTTTGTCCTTGCGAATCACACAGATTGAGTCTG
TGTTCCCCAGGGTGTGCCGTTACCTGATTTTTAAGTGAGCCAGGGCGGACAGCAGCTTTTCTGATTTACAGAGTTCTTCAGATTTACAAA
TGGACAATGACATCACAGTTTTTAGCACTGAAGCCAGTCTCATGCTAGTAACAGTGGGTGAGCCGCTCGAGGGACTGGGTTCTAATGAAT
ACTGGTATGAACGGGGAGTCTCTGCAGTCGCCAGACAAATCATACTCAGCCCCTTCCCCCGTAGAGCAACAAGTGGTTCTTTTAGAGTTG
ACTGGCAGCATTTCCTGTCGGGGGAGGTGGGGTTTGATGGAGTTAGAAAGCTCGCCTCTGTGTACATTCTCTCCTGGGCTGTTACTTTCT
GTAGACGCACAAAATCAGCCCCAATGTTTTTAAGGGCATCTTAGCCAAGGAAGCTGGCTTTTGTGTCGCCACTTCCAGGCCTGCATTAAG
AGAGAGCCCAGGCACCAGGGCTACCACTGGAACCTGCCTCAGCGTCAACTGCTGCTGGTCTGTAGCCAGGCCCAGCCTTTGAGACGGGTT
TACTGTCACCAGTAGCCTCTCAGTGCCAGCCCTGAGCTGCTCCTGGCTCAGCTGCCCAGAGCCTGCAGCCTGGGGAGGTACTCAGCCTCT
GGGAGACGAGGGCCGTGGACTGGGTGGCTGGTAGCTCCTGCGTTTTTGAGCTGTGTCCTGGCTGGCTGCTGCCAATGAGGTGGACACCAG
TGTGGTTTGGGGTGCACTGGCCACTTCTTGCTGGGTTCTGATTTTCTTGGAAGTGCATCTGCCTTCCTTATCCAATAGTTTTATCCCTGC
ATTGCTCTTGTGAAGTGGCTGGTTTGGTTCTGTATGTAGCATTTTGTACCTTTCCTCTGGCAAAACACTGTCAGTTTATAAACATTTTTT
ATATTTCCCTCCTTTAAAAACAGCTTGTGTATTTCTGCTATAAAATGTGTCAGCAAAGGCAGAGTGACCTAATAGGGCATGTTCTTAAGC

>43007_43007_5_KLHL2-STK24_KLHL2_chr4_166160051_ENST00000538127_STK24_chr13_99171727_ENST00000397517_length(amino acids)=456AA_BP=38
MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIE
DIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEH
GEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSK
PLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPK
NLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRLQRYSLSG

--------------------------------------------------------------
>43007_43007_6_KLHL2-STK24_KLHL2_chr4_166160051_ENST00000538127_STK24_chr13_99171727_ENST00000539966_length(transcript)=1865nt_BP=410nt
ACTGCCAGAGCTGGGCTAGAACAGAGGCCAGTGGAAACTATTAGGAAGACTCAGCTTTTCATGAAGTTAGATTTTTAGCCTGAGCTTTAA
GTCAAAGAAAGATGACCTGGACTTAAAGTGCCTTATGGTATGGTTGGAAGCACGGCCCCAGATTCTCTTTGTATGCACAAAGCAGGGTCA
TCAGAAGCCTCTCGATTCAAAAGATGATAATACCGAAAAACACTGCCCAGTGACAGTGAATCCTTGGCATATGAAGAAAGCTTTCAAAGT
CATGAACGAATTAAGAAGGTGAGATGAGTGAGAGCCGAGCAAAGAGAGTTAGAATAAAAGAGGTAGATGGCTGGACCCTGAGGATGCTAA
TTGATTATGTTTACACTGCAGAAATTCAGGTTACAGAAGAAAATGTACAGAACCTAAAGGCAGACCCAGAAGAGCTTTTTACAAAACTAG
AGAAAATTGGGAAGGGCTCCTTTGGAGAGGTGTTCAAAGGCATTGACAATCGGACTCAGAAAGTGGTTGCCATAAAGATCATTGATCTGG
AAGAAGCTGAAGATGAGATAGAGGACATTCAACAAGAAATCACAGTGCTGAGTCAGTGTGACAGTCCATATGTAACCAAATATTATGGAT
CCTATCTGAAGTTAGAACCTGGCCCATTAGATGAAACCCAGATCGCTACTATATTAAGAGAAATACTGAAAGGACTCGATTATCTCCATT
CGGAGAAGAAAATCCACAGAGACATTAAAGCGGCCAACGTCCTGCTGTCTGAGCATGGCGAGGTGAAGCTGGCGGACTTTGGCGTGGCTG
GCCAGCTGACAGACACCCAGATCAAAAGGAACACCTTCGTGGGCACCCCATTCTGGATGGCACCCGAGGTCATCAAACAGTCGGCCTATG
ACTCGAAGGCAGACATCTGGTCCCTGGGCATAACAGCTATTGAACTTGCAAGAGGGGAACCACCTCATTCCGAGCTGCACCCCATGAAAG
TTTTATTCCTCATTCCAAAGAACAACCCACCGACGTTGGAAGGAAACTACAGTAAACCCCTCAAGGAGTTTGTGGAGGCCTGTTTGAATA
AGGAGCCGAGCTTTAGACCCACTGCTAAGGAGTTATTGAAGCACAAGTTTATACTACGCAATGCAAAGAAAACTTCCTACTTGACCGAGC
TCATCGACAGGTACAAGAGATGGAAGGCCGAGCAGAGCCATGACGACTCGAGCTCCGAGGATTCCGACGCGGAAACAGATGGCCAAGCCT
CGGGGGGCAGTGATTCTGGGGACTGGATCTTCACAATCCGAGAAAAAGATCCCAAGAATCTCGAGAATGGAGCTCTTCAGCCATCGGACT
TGGACAGAAATAAGATGAAAGACATCCCGAAGAGGCCTTTCTCTCAGTGTTTATCTACAATTATTTCTCCTCTGTTTGCAGAGTTGAAGG
AGAAGAGCCAGGCGTGCGGAGGGAACTTGGGGTCCATTGAAGAGCTGCGAGGGGCCATCTACCTAGCGGAGGAGGCGTGCCCTGGCATCT
CCGACACCATGGTGGCCCAGCTCGTGCAGCGGCTCCAGAGATACTCTCTAAGTGGTGGAGGAACTTCATCCCACTGAAATTCCTTTGGCA
TTTGGGGTTTTGTTTTTCCTTTTTTCCTTCTTCATCCTCCTCCTTTTTTAAAAGTCAACGAGAGCCTTCGCTGACTCCACCGAAGAGGTG
CGCCACTGGGAGCCACCCCAGCGCCAGGCGCCCGTCCAGGGACACACACAGTCTTCACTGTGCTGCAGCCAGATGAAGTCTCTCAGATGG

>43007_43007_6_KLHL2-STK24_KLHL2_chr4_166160051_ENST00000538127_STK24_chr13_99171727_ENST00000539966_length(amino acids)=437AA_BP=38
MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIE
DIQQEITVLSQCDSPYVTKYYGSYLKLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQI
KRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPT
AKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KLHL2-STK24

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for KLHL2-STK24

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for KLHL2-STK24

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

Fusion Gene Studies in Kim Lab

Fusion gene:KLHL2-STK24 (FusionGDB2 ID:HG11275TG8428)

Fusion Gene Summary for KLHL2-STK24

Fusion Gene ORF analysis for KLHL2-STK24

Fusion Genomic Features for KLHL2-STK24

Fusion Protein Features for KLHL2-STK24

Fusion Gene Sequence for KLHL2-STK24

Fusion Gene PPI Analysis for KLHL2-STK24

Related Drugs for KLHL2-STK24

Related Diseases for KLHL2-STK24

Fusion Gene Studies
in Kim Lab