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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KLF12-CAMK2G (FusionGDB2 ID:HG11278TG818)

Fusion Gene Summary for KLF12-CAMK2G

check button Fusion gene summary
Fusion gene informationFusion gene name: KLF12-CAMK2G
Fusion gene ID: hg11278tg818
HgeneTgene
Gene symbol

KLF12

CAMK2G

Gene ID

11278

818

Gene nameKruppel like factor 12calcium/calmodulin dependent protein kinase II gamma
SynonymsAP-2rep|AP2REP|HSPC122CAMK|CAMK-II|CAMKG|MRD59
Cytomap('KLF12')('CAMK2G')

13q22.1

10q22.2

Type of geneprotein-codingprotein-coding
DescriptionKrueppel-like factor 12AP-2 repressorAP-2rep transcription factorKLF12 zinc finger transcriptional repressortranscriptional repressor AP-2repcalcium/calmodulin-dependent protein kinase type II subunit gammacaMK-II subunit gammacalcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000377666, ENST00000377669, 
ENST00000472022, 
Fusion gene scores* DoF score11 X 12 X 5=6609 X 8 X 6=432
# samples 1711
** MAII scorelog2(17/660*10)=-1.95693127810811
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/432*10)=-1.97352778863881
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KLF12 [Title/Abstract] AND CAMK2G [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKLF12(74518118)-CAMK2G(75577312), # samples:3
Anticipated loss of major functional domain due to fusion event.KLF12-CAMK2G seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KLF12-CAMK2G seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
KLF12-CAMK2G seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
KLF12-CAMK2G seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KLF12-CAMK2G seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKLF12

GO:0000122

negative regulation of transcription by RNA polymerase II

16615998



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-X6-A7WB-01AKLF12chr13

74518118

-CAMK2Gchr10

75577312

-
ChimerDB4SARCTCGA-X6-A7WBKLF12chr13

74518117

-CAMK2Gchr10

75577312

-


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Fusion Gene ORF analysis for KLF12-CAMK2G

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000377666ENST00000472912KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5CDS-5UTRENST00000377666ENST00000472912KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
5CDS-5UTRENST00000377669ENST00000472912KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5CDS-5UTRENST00000377669ENST00000472912KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
5CDS-intronENST00000377666ENST00000444854KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5CDS-intronENST00000377666ENST00000444854KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
5CDS-intronENST00000377669ENST00000444854KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5CDS-intronENST00000377669ENST00000444854KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
5UTR-3CDSENST00000472022ENST00000305762KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5UTR-3CDSENST00000472022ENST00000305762KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
5UTR-3CDSENST00000472022ENST00000322635KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5UTR-3CDSENST00000472022ENST00000322635KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
5UTR-3CDSENST00000472022ENST00000322680KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5UTR-3CDSENST00000472022ENST00000322680KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
5UTR-3CDSENST00000472022ENST00000351293KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5UTR-3CDSENST00000472022ENST00000351293KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
5UTR-3CDSENST00000472022ENST00000372765KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5UTR-3CDSENST00000472022ENST00000372765KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
5UTR-3CDSENST00000472022ENST00000394762KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5UTR-3CDSENST00000472022ENST00000394762KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
5UTR-3CDSENST00000472022ENST00000423381KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5UTR-3CDSENST00000472022ENST00000423381KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
5UTR-5UTRENST00000472022ENST00000472912KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5UTR-5UTRENST00000472022ENST00000472912KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
5UTR-intronENST00000472022ENST00000444854KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
5UTR-intronENST00000472022ENST00000444854KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377666ENST00000305762KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377666ENST00000305762KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377666ENST00000322635KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377666ENST00000322635KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377666ENST00000322680KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377666ENST00000322680KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377666ENST00000351293KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377666ENST00000351293KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377666ENST00000372765KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377666ENST00000372765KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377666ENST00000394762KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377666ENST00000394762KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377666ENST00000423381KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377666ENST00000423381KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377669ENST00000305762KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377669ENST00000305762KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377669ENST00000322635KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377669ENST00000322635KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377669ENST00000322680KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377669ENST00000322680KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377669ENST00000351293KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377669ENST00000351293KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377669ENST00000372765KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377669ENST00000372765KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377669ENST00000394762KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377669ENST00000394762KLF12chr13

74518117

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377669ENST00000423381KLF12chr13

74518118

-CAMK2Gchr10

75577312

-
Frame-shiftENST00000377669ENST00000423381KLF12chr13

74518117

-CAMK2Gchr10

75577312

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for KLF12-CAMK2G


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for KLF12-CAMK2G


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:74518118/:75577312)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for KLF12-CAMK2G


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for KLF12-CAMK2G


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KLF12-CAMK2G


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KLF12-CAMK2G


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKLF12C0013146Drug abuse1CTD_human
HgeneKLF12C0013170Drug habituation1CTD_human
HgeneKLF12C0013222Drug Use Disorders1CTD_human
HgeneKLF12C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneKLF12C0036341Schizophrenia1CTD_human
HgeneKLF12C0038580Substance Dependence1CTD_human
HgeneKLF12C0038586Substance Use Disorders1CTD_human
HgeneKLF12C0236969Substance-Related Disorders1CTD_human
HgeneKLF12C0740858Substance abuse problem1CTD_human
HgeneKLF12C1510472Drug Dependence1CTD_human
HgeneKLF12C4316881Prescription Drug Abuse1CTD_human
TgeneC4552072X-linked infantile spasms1GENOMICS_ENGLAND