![]() |
||||||
|
![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CHRM3-UBE2N (FusionGDB2 ID:HG1131TG7334) |
Fusion Gene Summary for CHRM3-UBE2N |
![]() |
Fusion gene information | Fusion gene name: CHRM3-UBE2N | Fusion gene ID: hg1131tg7334 | Hgene | Tgene | Gene symbol | CHRM3 | UBE2N | Gene ID | 1131 | 7334 |
Gene name | cholinergic receptor muscarinic 3 | ubiquitin conjugating enzyme E2 N | |
Synonyms | EGBRS|HM3|PBS | HEL-S-71|UBC13|UBCHBEN; UBC13|UbcH-ben|UbcH13 | |
Cytomap | ('CHRM3')('UBE2N') 1q43 | 12q22 | |
Type of gene | protein-coding | protein-coding | |
Description | muscarinic acetylcholine receptor M3acetylcholine receptor, muscarinic 3m3 muscarinic receptor | ubiquitin-conjugating enzyme E2 NE2 ubiquitin-conjugating enzyme Nbendless-like ubiquitin conjugating enzymeepididymis secretory protein Li 71ubiquitin carrier protein Nubiquitin conjugating enzyme E2Nubiquitin-conjugating enzyme E2N (UBC13 homolog, | |
Modification date | 20200327 | 20200313 | |
UniProtAcc | P20309 | . | |
Ensembl transtripts involved in fusion gene | ENST00000468573, ENST00000255380, | ||
Fusion gene scores | * DoF score | 12 X 12 X 7=1008 | 9 X 5 X 6=270 |
# samples | 14 | 12 | |
** MAII score | log2(14/1008*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/270*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CHRM3 [Title/Abstract] AND UBE2N [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CHRM3(239550527)-UBE2N(93805075), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | UBE2N | GO:0070534 | protein K63-linked ubiquitination | 16307917|20061386|21512573|31006531 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-FP-8211-01A | CHRM3 | chr1 | 239550527 | + | UBE2N | chr12 | 93805075 | - |
Top |
Fusion Gene ORF analysis for CHRM3-UBE2N |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-5UTR | ENST00000468573 | ENST00000549833 | CHRM3 | chr1 | 239550527 | + | UBE2N | chr12 | 93805075 | - |
3UTR-5UTR | ENST00000468573 | ENST00000552442 | CHRM3 | chr1 | 239550527 | + | UBE2N | chr12 | 93805075 | - |
3UTR-intron | ENST00000468573 | ENST00000318066 | CHRM3 | chr1 | 239550527 | + | UBE2N | chr12 | 93805075 | - |
3UTR-intron | ENST00000468573 | ENST00000548946 | CHRM3 | chr1 | 239550527 | + | UBE2N | chr12 | 93805075 | - |
3UTR-intron | ENST00000468573 | ENST00000550657 | CHRM3 | chr1 | 239550527 | + | UBE2N | chr12 | 93805075 | - |
intron-5UTR | ENST00000255380 | ENST00000549833 | CHRM3 | chr1 | 239550527 | + | UBE2N | chr12 | 93805075 | - |
intron-5UTR | ENST00000255380 | ENST00000552442 | CHRM3 | chr1 | 239550527 | + | UBE2N | chr12 | 93805075 | - |
intron-intron | ENST00000255380 | ENST00000318066 | CHRM3 | chr1 | 239550527 | + | UBE2N | chr12 | 93805075 | - |
intron-intron | ENST00000255380 | ENST00000548946 | CHRM3 | chr1 | 239550527 | + | UBE2N | chr12 | 93805075 | - |
intron-intron | ENST00000255380 | ENST00000550657 | CHRM3 | chr1 | 239550527 | + | UBE2N | chr12 | 93805075 | - |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
Top |
Fusion Genomic Features for CHRM3-UBE2N |
![]() |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Top |
Fusion Protein Features for CHRM3-UBE2N |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:239550527/:93805075) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
![]() |
![]() |
Hgene | Tgene |
CHRM3 | . |
FUNCTION: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. {ECO:0000269|PubMed:7565628}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for CHRM3-UBE2N |
![]() |
Top |
Fusion Gene PPI Analysis for CHRM3-UBE2N |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for CHRM3-UBE2N |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | CHRM3 | P20309 | DB00185 | Cevimeline | Agonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB00202 | Succinylcholine | Agonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB00209 | Trospium | Small molecule | Approved | |
Hgene | CHRM3 | P20309 | DB00246 | Ziprasidone | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB00280 | Disopyramide | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB00363 | Clozapine | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB00376 | Trihexyphenidyl | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB00383 | Oxyphencyclimine | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB00387 | Procyclidine | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB00408 | Loxapine | Binder | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB00411 | Carbamoylcholine | Small molecule | Approved | |
Hgene | CHRM3 | P20309 | DB00424 | Hyoscyamine | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB00434 | Cyproheptadine | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB00458 | Imipramine | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB00462 | Methscopolamine bromide | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB00502 | Haloperidol | Small molecule | Approved | |
Hgene | CHRM3 | P20309 | DB00517 | Anisotropine methylbromide | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB00725 | Homatropine methylbromide | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB00835 | Brompheniramine | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB01019 | Bethanechol | Small molecule | Approved | |
Hgene | CHRM3 | P20309 | DB01224 | Quetiapine | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB01226 | Mivacurium | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB01337 | Pancuronium | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB01338 | Pipecuronium | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB01409 | Tiotropium | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB01591 | Solifenacin | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB04843 | Mepenzolate | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB06153 | Pizotifen | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB06702 | Fesoterodine | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB06787 | Hexocyclium | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB08897 | Aclidinium | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB09076 | Umeclidinium | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB09089 | Trimebutine | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB09167 | Dosulepin | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB11181 | Homatropine | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB11235 | Thonzylamine | Antagonist | Small molecule | Approved |
Hgene | CHRM3 | P20309 | DB00332 | Ipratropium | Antagonist | Small molecule | Approved|Experimental |
Hgene | CHRM3 | P20309 | DB01239 | Chlorprothixene | Antagonist | Small molecule | Approved|Experimental|Investigational|Withdrawn |
Hgene | CHRM3 | P20309 | DB00193 | Tramadol | Antagonist | Small molecule | Approved|Investigational |
Hgene | CHRM3 | P20309 | DB00334 | Olanzapine | Antagonist | Small molecule | Approved|Investigational |
Hgene | CHRM3 | P20309 | DB00496 | Darifenacin | Antagonist | Small molecule | Approved|Investigational |
Hgene | CHRM3 | P20309 | DB00622 | Nicardipine | Antagonist | Small molecule | Approved|Investigational |
Hgene | CHRM3 | P20309 | DB00747 | Scopolamine | Antagonist | Small molecule | Approved|Investigational |
Hgene | CHRM3 | P20309 | DB00809 | Tropicamide | Antagonist | Small molecule | Approved|Investigational |
Hgene | CHRM3 | P20309 | DB00934 | Maprotiline | Antagonist | Small molecule | Approved|Investigational |
Hgene | CHRM3 | P20309 | DB00940 | Methantheline | Small molecule | Approved|Investigational | |
Hgene | CHRM3 | P20309 | DB01036 | Tolterodine | Antagonist | Small molecule | Approved|Investigational |
Hgene | CHRM3 | P20309 | DB01062 | Oxybutynin | Antagonist | Small molecule | Approved|Investigational |
Hgene | CHRM3 | P20309 | DB01069 | Promethazine | Antagonist | Small molecule | Approved|Investigational |
Hgene | CHRM3 | P20309 | DB01085 | Pilocarpine | Agonist | Small molecule | Approved|Investigational |
Hgene | CHRM3 | P20309 | DB01142 | Doxepin | Antagonist | Small molecule | Approved|Investigational |
Hgene | CHRM3 | P20309 | DB01151 | Desipramine | Antagonist | Small molecule | Approved|Investigational |
Hgene | CHRM3 | P20309 | DB01238 | Aripiprazole | Ligand | Small molecule | Approved|Investigational |
Hgene | CHRM3 | P20309 | DB01403 | Methotrimeprazine | Antagonist | Small molecule | Approved|Investigational |
Hgene | CHRM3 | P20309 | DB03128 | Acetylcholine | Small molecule | Approved|Investigational | |
Hgene | CHRM3 | P20309 | DB06709 | Methacholine | Agonist | Small molecule | Approved|Investigational |
Hgene | CHRM3 | P20309 | DB12278 | Propiverine | Antagonist | Small molecule | Approved|Investigational |
Hgene | CHRM3 | P20309 | DB14185 | Aripiprazole lauroxil | Small molecule | Approved|Investigational | |
Hgene | CHRM3 | P20309 | DB00477 | Chlorpromazine | Antagonist | Small molecule | Approved|Investigational|Vet_approved |
Hgene | CHRM3 | P20309 | DB00986 | Glycopyrronium | Antagonist | Small molecule | Approved|Investigational|Vet_approved |
Hgene | CHRM3 | P20309 | DB09300 | Butylscopolamine | Antagonist | Small molecule | Approved|Investigational|Vet_approved |
Hgene | CHRM3 | P20309 | DB01231 | Diphenidol | Antagonist | Small molecule | Approved|Investigational|Withdrawn |
Hgene | CHRM3 | P20309 | DB00572 | Atropine | Antagonist | Small molecule | Approved|Vet_approved |
Hgene | CHRM3 | P20309 | DB00599 | Thiopental | Small molecule | Approved|Vet_approved | |
Hgene | CHRM3 | P20309 | DB01625 | Isopropamide | Antagonist | Small molecule | Approved|Vet_approved |
Hgene | CHRM3 | P20309 | DB13720 | Diphemanil | Antagonist | Small molecule | Approved|Vet_approved|Withdrawn |
Hgene | CHRM3 | P20309 | DB00342 | Terfenadine | Antagonist | Small molecule | Approved|Withdrawn |
Top |
Related Diseases for CHRM3-UBE2N |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CHRM3 | C0003962 | Ascites | 1 | CTD_human |
Hgene | CHRM3 | C0005686 | Urinary Bladder Diseases | 1 | CTD_human |
Hgene | CHRM3 | C0010417 | Cryptorchidism | 1 | CTD_human |
Hgene | CHRM3 | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
Hgene | CHRM3 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Hgene | CHRM3 | C0033770 | Prune Belly Syndrome | 1 | CTD_human;ORPHANET |
Hgene | CHRM3 | C0239946 | Fibrosis, Liver | 1 | CTD_human |
Hgene | CHRM3 | C0265363 | Urethral obstruction sequence | 1 | ORPHANET |
Hgene | CHRM3 | C0431663 | Bilateral Cryptorchidism | 1 | CTD_human |
Hgene | CHRM3 | C0431664 | Unilateral Cryptorchidism | 1 | CTD_human |
Hgene | CHRM3 | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
Hgene | CHRM3 | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
Hgene | CHRM3 | C1563730 | Abdominal Cryptorchidism | 1 | CTD_human |
Hgene | CHRM3 | C1563731 | Inguinal Cryptorchidism | 1 | CTD_human |
Hgene | CHRM3 | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
Hgene | CHRM3 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Hgene | CHRM3 | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |
Tgene | C0012684 | Blastocyst Disintegration | 1 | CTD_human | |
Tgene | C0013937 | Embryo Resorption | 1 | CTD_human | |
Tgene | C0752350 | Embryo Death | 1 | CTD_human | |
Tgene | C0752351 | Embryo Loss | 1 | CTD_human | |
Tgene | C1136082 | Embryo Disintegration | 1 | CTD_human |