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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FKBP9-RNPEP (FusionGDB2 ID:HG11328TG6051)

Fusion Gene Summary for FKBP9-RNPEP

check button Fusion gene summary
Fusion gene informationFusion gene name: FKBP9-RNPEP
Fusion gene ID: hg11328tg6051
HgeneTgene
Gene symbol

FKBP9

RNPEP

Gene ID

11328

6051

Gene nameFKBP prolyl isomerase 9arginyl aminopeptidase
SynonymsFKBP60|FKBP63|PPIaseAP-B|APB
Cytomap('FKBP9')('RNPEP')

7p14.3

1q32.1

Type of geneprotein-codingprotein-coding
Descriptionpeptidyl-prolyl cis-trans isomerase FKBP963 kDa FK506-binding protein63 kDa FKBPFK506 binding protein 9, 63 kDaFK506-binding protein 9FKBP-63FKBP-9PPIase FKBP9rotamaseaminopeptidase Barginine aminopeptidase
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000242209, ENST00000490776, 
ENST00000538336, ENST00000538443, 
ENST00000489038, 
Fusion gene scores* DoF score7 X 7 X 4=1967 X 7 X 5=245
# samples 79
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/245*10)=-1.4447848426729
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FKBP9 [Title/Abstract] AND RNPEP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFKBP9(33035961)-RNPEP(201965274), # samples:1
Anticipated loss of major functional domain due to fusion event.FKBP9-RNPEP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FKBP9-RNPEP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FKBP9-RNPEP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FKBP9-RNPEP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FKBP9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RNPEP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A48OFKBP9chr7

33035961

+RNPEPchr1

201965274

+


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Fusion Gene ORF analysis for FKBP9-RNPEP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000242209ENST00000471105FKBP9chr7

33035961

+RNPEPchr1

201965274

+
5CDS-3UTRENST00000490776ENST00000471105FKBP9chr7

33035961

+RNPEPchr1

201965274

+
5CDS-3UTRENST00000538336ENST00000471105FKBP9chr7

33035961

+RNPEPchr1

201965274

+
5CDS-3UTRENST00000538443ENST00000471105FKBP9chr7

33035961

+RNPEPchr1

201965274

+
5CDS-intronENST00000242209ENST00000367286FKBP9chr7

33035961

+RNPEPchr1

201965274

+
5CDS-intronENST00000490776ENST00000367286FKBP9chr7

33035961

+RNPEPchr1

201965274

+
5CDS-intronENST00000538336ENST00000367286FKBP9chr7

33035961

+RNPEPchr1

201965274

+
5CDS-intronENST00000538443ENST00000367286FKBP9chr7

33035961

+RNPEPchr1

201965274

+
In-frameENST00000242209ENST00000295640FKBP9chr7

33035961

+RNPEPchr1

201965274

+
In-frameENST00000490776ENST00000295640FKBP9chr7

33035961

+RNPEPchr1

201965274

+
In-frameENST00000538336ENST00000295640FKBP9chr7

33035961

+RNPEPchr1

201965274

+
In-frameENST00000538443ENST00000295640FKBP9chr7

33035961

+RNPEPchr1

201965274

+
intron-3CDSENST00000489038ENST00000295640FKBP9chr7

33035961

+RNPEPchr1

201965274

+
intron-3UTRENST00000489038ENST00000471105FKBP9chr7

33035961

+RNPEPchr1

201965274

+
intron-intronENST00000489038ENST00000367286FKBP9chr7

33035961

+RNPEPchr1

201965274

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000242209FKBP9chr733035961+ENST00000295640RNPEPchr1201965274+304213951692610813
ENST00000538336FKBP9chr733035961+ENST00000295640RNPEPchr1201965274+316515181332733866
ENST00000538443FKBP9chr733035961+ENST00000295640RNPEPchr1201965274+282711803652395676
ENST00000490776FKBP9chr733035961+ENST00000295640RNPEPchr1201965274+2255608781823581

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000242209ENST00000295640FKBP9chr733035961+RNPEPchr1201965274+0.0011162050.9988838
ENST00000538336ENST00000295640FKBP9chr733035961+RNPEPchr1201965274+0.0006422550.99935776
ENST00000538443ENST00000295640FKBP9chr733035961+RNPEPchr1201965274+0.0018013290.9981987
ENST00000490776ENST00000295640FKBP9chr733035961+RNPEPchr1201965274+0.0012790290.99872094

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Fusion Genomic Features for FKBP9-RNPEP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FKBP9chr733035961+RNPEPchr1201965274+0.000210280.9997898
FKBP9chr733035961+RNPEPchr1201965274+0.000210280.9997898

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FKBP9-RNPEP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:33035961/chr1:201965274)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFKBP9chr7:33035961chr1:201965274ENST00000242209+710166_254408571.0DomainPPIase FKBP-type 2
HgeneFKBP9chr7:33035961chr1:201965274ENST00000242209+710278_365408571.0DomainPPIase FKBP-type 3
HgeneFKBP9chr7:33035961chr1:201965274ENST00000242209+71054_142408571.0DomainPPIase FKBP-type 1
TgeneRNPEPchr7:33035961chr1:201965274ENST00000295640211298_302245651.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFKBP9chr7:33035961chr1:201965274ENST00000242209+710501_513408571.0Calcium binding1
HgeneFKBP9chr7:33035961chr1:201965274ENST00000242209+710546_557408571.0Calcium binding2
HgeneFKBP9chr7:33035961chr1:201965274ENST00000242209+710389_477408571.0DomainPPIase FKBP-type 4
HgeneFKBP9chr7:33035961chr1:201965274ENST00000242209+710488_523408571.0DomainEF-hand 1
HgeneFKBP9chr7:33035961chr1:201965274ENST00000242209+710533_568408571.0DomainEF-hand 2
HgeneFKBP9chr7:33035961chr1:201965274ENST00000242209+710567_570408571.0MotifPrevents secretion from ER


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Fusion Gene Sequence for FKBP9-RNPEP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30544_30544_1_FKBP9-RNPEP_FKBP9_chr7_33035961_ENST00000242209_RNPEP_chr1_201965274_ENST00000295640_length(transcript)=3042nt_BP=1395nt
CCCTGGAGCTGCGGCCGGGAGGGCGGGCGGCCGGGGAGACGGGGTGGCGGCTGCAGCCCGGGTAGGGCCAGGAGACCCGGTCCACGTTTG
CAAACGCAGCCGAACGCCCAGGCCGACCCGTGCCGCCCGAGCGCCGCGCTGCGTCCGCGCCACTCTTCTCGCCGCCCCGATGGCGTTCCG
GGGCTGGAGGCCCCCGCCGCCACCGCTGCTCCTGCTGCTGCTCTGGGTGACCGGGCAGGCAGCGCCCGTGGCGGGCCTGGGCTCCGACGC
GGAGCTGCAGATCGAGCGGCGCTTCGTGCCCGACGAGTGCCCGCGCACCGTGCGCAGCGGCGACTTCGTGCGCTACCACTACGTGGGGAC
GTTCCCCGACGGCCAGAAGTTCGACTCCAGCTATGACAGAGACTCCACTTTCAATGTGTTTGTGGGAAAAGGACAGCTGATCACAGGGAT
GGACCAGGCTCTTGTTGGGATGTGCGTAAACGAGAGACGTTTCGTGAAGATTCCCCCAAAGCTTGCCTACGGAAATGAAGGAGTTTCTGG
TGTGATCCCCCCCAATTCAGTGCTTCATTTTGATGTACTTCTGATGGATATTTGGAATTCTGAAGACCAGGTTCAGATTCACACCTATTT
CAAGCCCCCGAGTTGCCCTCGGACCATCCAGGTGTCTGATTTTGTGAGGTACCACTACAACGGGACGTTCCTGGACGGAACTCTGTTTGA
TTCGAGTCACAATCGCATGAAAACATATGACACGTATGTGGGAATTGGCTGGCTGATTCCTGGAATGGATAAAGGGCTGCTGGGGATGTG
TGTGGGTGAGAAGCGCATCATCACCATTCCTCCTTTTCTGGCCTATGGAGAGGATGGAGATGGGAAAGACATTCCCGGTCAGGCATCTCT
GGTGTTTGATGTTGCATTATTGGACCTCCATAACCCCAAGGACAGCATTTCCATTGAGAACAAGGTAGTACCTGAAAACTGTGAGCGGAT
AAGTCAAAGTGGGGACTTTCTCAGGTATCATTACAATGGCACGCTTCTGGATGGCACCCTCTTTGATTCCAGCTACTCTCGGAACCGCAC
GTTTGACACGTACATTGGGCAGGGCTACGTGATTCCTGGGATGGATGAAGGTCTACTTGGTGTTTGCATTGGAGAAAAGCGAAGGATTGT
GGTCCCGCCTCACCTGGGGTATGGAGAGGAAGGAAGAGGGAATATCCCCGGCTCGGCTGTGCTGGTGTTTGACATCCATGTGATCGACTT
CCACAACCCTTCGGACTCCATCAGCATCACCTCCCACTACAAACCCCCTGACTGCTCAGTGCTGAGTAAGAAGGGAGATTACCTCAAATA
TCACTACAATGCCTCACTTCTGGATGGGACCCTGCTGGACTCCACGAGCCGGGTGTGGGCTGAGCCCTGCCTGATTGATGCTGCCAAGGA
GGAGTACAACGGGGTGATAGAAGAATTTTTGGCAACAGGAGAGAAGCTTTTTGGACCTTATGTTTGGGGAAGGTATGACTTGCTCTTCAT
GCCACCGTCCTTTCCATTTGGAGGAATGGAGAACCCTTGTCTGACCTTTGTCACCCCCTGCCTGCTAGCTGGGGACCGCTCCTTGGCAGA
TGTCATCATCCATGAGATCTCCCACAGTTGGTTTGGGAACCTGGTCACCAACGCCAACTGGGGTGAATTCTGGCTCAATGAAGGTTTCAC
CATGTACGCCCAGAGGAGGATCTCCACCATCCTCTTTGGCGCTGCGTACACCTGCTTGGAGGCTGCAACGGGGCGGGCTCTGCTGCGTCA
GCACATGGACATCACTGGAGAGGAAAACCCACTCAACAAGCTCCGCGTGAAGATTGAACCAGGCGTTGACCCGGACGACACCTATAATGA
GACCCCCTACGAGAAAGGTTTCTGCTTTGTTTCATACCTGGCCCACTTGGTGGGTGATCAGGATCAGTTTGACAGTTTTCTCAAGGCCTA
TGTGCATGAATTCAAATTCCGAAGCATCTTAGCCGATGACTTTCTGGACTTCTACTTGGAATATTTCCCTGAGCTTAAGAAAAAGAGAGT
GGATATCATTCCAGGTTTTGAGTTTGATCGATGGCTGAATACCCCCGGCTGGCCCCCGTACCTCCCTGATCTCTCCCCTGGGGACTCACT
CATGAAGCCTGCTGAAGAGCTAGCCCAACTGTGGGCAGCCGAGGAGCTGGACATGAAGGCCATTGAAGCCGTGGCCATCTCTCCCTGGAA
GACCTACCAGCTGGTCTACTTCCTGGATAAGATCCTCCAGAAATCCCCTCTCCCTCCTGGGAATGTGAAAAAACTTGGAGACACATACCC
AAGTATCTCAAATGCCCGGAATGCAGAGCTCCGGCTGCGATGGGGCCAAATCGTCCTTAAGAACGACCACCAGGAAGATTTCTGGAAAGT
GAAGGAGTTCCTGCATAACCAGGGGAAGCAGAAGTATACACTTCCGCTGTACCACGCAATGATGGGTGGCAGTGAGGTGGCCCAGACCCT
CGCCAAGGAGACTTTTGCATCCACCGCCTCCCAGCTCCACAGCAATGTTGTCAACTATGTCCAGCAGATCGTGGCACCCAAGGGCAGTTA
GAGGCTCGTGTGCATGGCCCCTGCCTCTTCAGGCTCTCCAGGCTTTCAGAATAATTGTTTGTTCCCAAATTCCTGTTCCCTGATCAACTT
CCTGGAGTTTATATCCCCTCAGGATAATCTATTCTCTAGCTTAGGTATCTGTGACTCTTGGGCCTCTGCTCTGGTGGGAACTTACTTCTC
TATAGCCCACTGAGCCCCGAGACAGAGAACCTGCCCACAGCTCTCCCCGCTACAGGCTGCAGGCACTGCAGGGCAGCGGGTATTCTCCTC
CCCACCTAAGTCTCTGGGAAGAAGTGGAGAGGACTGATGCTCTTCTTTTTTCTCTTTCTGTCCTTTTTCTTGCTGATTTTATGCAAAGGG
CTGGCATTCTGATTGTTCTTTTTTCAGGTTTAATCCTTATTTTAATAAAGTTTTCAAGCAAAAATTAAGTTA

>30544_30544_1_FKBP9-RNPEP_FKBP9_chr7_33035961_ENST00000242209_RNPEP_chr1_201965274_ENST00000295640_length(amino acids)=813AA_BP=409
MAFRGWRPPPPPLLLLLLWVTGQAAPVAGLGSDAELQIERRFVPDECPRTVRSGDFVRYHYVGTFPDGQKFDSSYDRDSTFNVFVGKGQL
ITGMDQALVGMCVNERRFVKIPPKLAYGNEGVSGVIPPNSVLHFDVLLMDIWNSEDQVQIHTYFKPPSCPRTIQVSDFVRYHYNGTFLDG
TLFDSSHNRMKTYDTYVGIGWLIPGMDKGLLGMCVGEKRIITIPPFLAYGEDGDGKDIPGQASLVFDVALLDLHNPKDSISIENKVVPEN
CERISQSGDFLRYHYNGTLLDGTLFDSSYSRNRTFDTYIGQGYVIPGMDEGLLGVCIGEKRRIVVPPHLGYGEEGRGNIPGSAVLVFDIH
VIDFHNPSDSISITSHYKPPDCSVLSKKGDYLKYHYNASLLDGTLLDSTSRVWAEPCLIDAAKEEYNGVIEEFLATGEKLFGPYVWGRYD
LLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRA
LLRQHMDITGEENPLNKLRVKIEPGVDPDDTYNETPYEKGFCFVSYLAHLVGDQDQFDSFLKAYVHEFKFRSILADDFLDFYLEYFPELK
KKRVDIIPGFEFDRWLNTPGWPPYLPDLSPGDSLMKPAEELAQLWAAEELDMKAIEAVAISPWKTYQLVYFLDKILQKSPLPPGNVKKLG
DTYPSISNARNAELRLRWGQIVLKNDHQEDFWKVKEFLHNQGKQKYTLPLYHAMMGGSEVAQTLAKETFASTASQLHSNVVNYVQQIVAP
KGS

--------------------------------------------------------------
>30544_30544_2_FKBP9-RNPEP_FKBP9_chr7_33035961_ENST00000490776_RNPEP_chr1_201965274_ENST00000295640_length(transcript)=2255nt_BP=608nt
AAAGGCCAGTGGAAGGAGCTCAGGCTTGGCGGCATCTGGTTTGCTTGTCTGGGCCTACTCCTTTGCATGATATAACAAATGGCAGGGAAA
GACATTCCCGGTCAGGCATCTCTGGTGTTTGATGTTGCATTATTGGACCTCCATAACCCCAAGGACAGCATTTCCATTGAGAACAAGGTA
GTACCTGAAAACTGTGAGCGGATAAGTCAAAGTGGGGACTTTCTCAGGTATCATTACAATGGCACGCTTCTGGATGGCACCCTCTTTGAT
TCCAGCTACTCTCGGAACCGCACGTTTGACACGTACATTGGGCAGGGCTACGTGATTCCTGGGATGGATGAAGGTCTACTTGGTGTTTGC
ATTGGAGAAAAGCGAAGGATTGTGGTCCCGCCTCACCTGGGGTATGGAGAGGAAGGAAGAGGGAATATCCCCGGCTCGGCTGTGCTGGTG
TTTGACATCCATGTGATCGACTTCCACAACCCTTCGGACTCCATCAGCATCACCTCCCACTACAAACCCCCTGACTGCTCAGTGCTGAGT
AAGAAGGGAGATTACCTCAAATATCACTACAATGCCTCACTTCTGGATGGGACCCTGCTGGACTCCACGAGCCGGGTGTGGGCTGAGCCC
TGCCTGATTGATGCTGCCAAGGAGGAGTACAACGGGGTGATAGAAGAATTTTTGGCAACAGGAGAGAAGCTTTTTGGACCTTATGTTTGG
GGAAGGTATGACTTGCTCTTCATGCCACCGTCCTTTCCATTTGGAGGAATGGAGAACCCTTGTCTGACCTTTGTCACCCCCTGCCTGCTA
GCTGGGGACCGCTCCTTGGCAGATGTCATCATCCATGAGATCTCCCACAGTTGGTTTGGGAACCTGGTCACCAACGCCAACTGGGGTGAA
TTCTGGCTCAATGAAGGTTTCACCATGTACGCCCAGAGGAGGATCTCCACCATCCTCTTTGGCGCTGCGTACACCTGCTTGGAGGCTGCA
ACGGGGCGGGCTCTGCTGCGTCAGCACATGGACATCACTGGAGAGGAAAACCCACTCAACAAGCTCCGCGTGAAGATTGAACCAGGCGTT
GACCCGGACGACACCTATAATGAGACCCCCTACGAGAAAGGTTTCTGCTTTGTTTCATACCTGGCCCACTTGGTGGGTGATCAGGATCAG
TTTGACAGTTTTCTCAAGGCCTATGTGCATGAATTCAAATTCCGAAGCATCTTAGCCGATGACTTTCTGGACTTCTACTTGGAATATTTC
CCTGAGCTTAAGAAAAAGAGAGTGGATATCATTCCAGGTTTTGAGTTTGATCGATGGCTGAATACCCCCGGCTGGCCCCCGTACCTCCCT
GATCTCTCCCCTGGGGACTCACTCATGAAGCCTGCTGAAGAGCTAGCCCAACTGTGGGCAGCCGAGGAGCTGGACATGAAGGCCATTGAA
GCCGTGGCCATCTCTCCCTGGAAGACCTACCAGCTGGTCTACTTCCTGGATAAGATCCTCCAGAAATCCCCTCTCCCTCCTGGGAATGTG
AAAAAACTTGGAGACACATACCCAAGTATCTCAAATGCCCGGAATGCAGAGCTCCGGCTGCGATGGGGCCAAATCGTCCTTAAGAACGAC
CACCAGGAAGATTTCTGGAAAGTGAAGGAGTTCCTGCATAACCAGGGGAAGCAGAAGTATACACTTCCGCTGTACCACGCAATGATGGGT
GGCAGTGAGGTGGCCCAGACCCTCGCCAAGGAGACTTTTGCATCCACCGCCTCCCAGCTCCACAGCAATGTTGTCAACTATGTCCAGCAG
ATCGTGGCACCCAAGGGCAGTTAGAGGCTCGTGTGCATGGCCCCTGCCTCTTCAGGCTCTCCAGGCTTTCAGAATAATTGTTTGTTCCCA
AATTCCTGTTCCCTGATCAACTTCCTGGAGTTTATATCCCCTCAGGATAATCTATTCTCTAGCTTAGGTATCTGTGACTCTTGGGCCTCT
GCTCTGGTGGGAACTTACTTCTCTATAGCCCACTGAGCCCCGAGACAGAGAACCTGCCCACAGCTCTCCCCGCTACAGGCTGCAGGCACT
GCAGGGCAGCGGGTATTCTCCTCCCCACCTAAGTCTCTGGGAAGAAGTGGAGAGGACTGATGCTCTTCTTTTTTCTCTTTCTGTCCTTTT
TCTTGCTGATTTTATGCAAAGGGCTGGCATTCTGATTGTTCTTTTTTCAGGTTTAATCCTTATTTTAATAAAGTTTTCAAGCAAAAATTA
AGTTA

>30544_30544_2_FKBP9-RNPEP_FKBP9_chr7_33035961_ENST00000490776_RNPEP_chr1_201965274_ENST00000295640_length(amino acids)=581AA_BP=177
MAGKDIPGQASLVFDVALLDLHNPKDSISIENKVVPENCERISQSGDFLRYHYNGTLLDGTLFDSSYSRNRTFDTYIGQGYVIPGMDEGL
LGVCIGEKRRIVVPPHLGYGEEGRGNIPGSAVLVFDIHVIDFHNPSDSISITSHYKPPDCSVLSKKGDYLKYHYNASLLDGTLLDSTSRV
WAEPCLIDAAKEEYNGVIEEFLATGEKLFGPYVWGRYDLLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGNLVTNA
NWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRALLRQHMDITGEENPLNKLRVKIEPGVDPDDTYNETPYEKGFCFVSYLAHLVG
DQDQFDSFLKAYVHEFKFRSILADDFLDFYLEYFPELKKKRVDIIPGFEFDRWLNTPGWPPYLPDLSPGDSLMKPAEELAQLWAAEELDM
KAIEAVAISPWKTYQLVYFLDKILQKSPLPPGNVKKLGDTYPSISNARNAELRLRWGQIVLKNDHQEDFWKVKEFLHNQGKQKYTLPLYH
AMMGGSEVAQTLAKETFASTASQLHSNVVNYVQQIVAPKGS

--------------------------------------------------------------
>30544_30544_3_FKBP9-RNPEP_FKBP9_chr7_33035961_ENST00000538336_RNPEP_chr1_201965274_ENST00000295640_length(transcript)=3165nt_BP=1518nt
AGACGGGGTGGCGGCTGCAGCCCGGGTAGGGCCAGGAGACCCGGTCCACGTTTGCAAACGCAGCCGAACGCCCAGGCCGACCCGTGCCGC
CCGAGCGCCGCGCTGCGTCCGCGCCACTCTTCTCGCCGCCCCGATGGCGTTCCGGGGCTGGAGGCCCCCGCCGCCACCGCTGCTCCTGCT
GCTGCTCTGGGTGACCGGGCAGGCAGCGCCCGTGGCGGGCCTGGGCTCCGACGCGGAGCTGCAGATCGAGCGGCGCTTCGTGCCCGACGA
GTGCCCGCGCACCGTGCGCAGCGGCGACTTCGTGCGCTACCACTACGTGGGGACGTTCCCCGACGGCCAGAAGTTCGACTCCAGGTACTG
GGATACAGCGGAGGATAAAGCTGACAAAAGTCCCTGCCCTCAAGTCAGGGTTGGGGTGAACACAAGCCCGTCCTGCAGACTTAAGCAGAA
AGGAGTGGGAATTTATTGGAAGGATCTCCAATTCCTTGTGAGGGTCCAGAATCATGGACTGAGCTATGACAGAGACTCCACTTTCAATGT
GTTTGTGGGAAAAGGACAGCTGATCACAGGGATGGACCAGGCTCTTGTTGGGATGTGCGTAAACGAGAGACGTTTCGTGAAGATTCCCCC
AAAGCTTGCCTACGGAAATGAAGGAGTTTCTGGTGTGATCCCCCCCAATTCAGTGCTTCATTTTGATGTACTTCTGATGGATATTTGGAA
TTCTGAAGACCAGGTTCAGATTCACACCTATTTCAAGCCCCCGAGTTGCCCTCGGACCATCCAGGTGTCTGATTTTGTGAGGTACCACTA
CAACGGGACGTTCCTGGACGGAACTCTGTTTGATTCGAGTCACAATCGCATGAAAACATATGACACGTATGTGGGAATTGGCTGGCTGAT
TCCTGGAATGGATAAAGGGCTGCTGGGGATGTGTGTGGGTGAGAAGCGCATCATCACCATTCCTCCTTTTCTGGCCTATGGAGAGGATGG
AGATGGGAAAGACATTCCCGGTCAGGCATCTCTGGTGTTTGATGTTGCATTATTGGACCTCCATAACCCCAAGGACAGCATTTCCATTGA
GAACAAGGTAGTACCTGAAAACTGTGAGCGGATAAGTCAAAGTGGGGACTTTCTCAGGTATCATTACAATGGCACGCTTCTGGATGGCAC
CCTCTTTGATTCCAGCTACTCTCGGAACCGCACGTTTGACACGTACATTGGGCAGGGCTACGTGATTCCTGGGATGGATGAAGGTCTACT
TGGTGTTTGCATTGGAGAAAAGCGAAGGATTGTGGTCCCGCCTCACCTGGGGTATGGAGAGGAAGGAAGAGGGAATATCCCCGGCTCGGC
TGTGCTGGTGTTTGACATCCATGTGATCGACTTCCACAACCCTTCGGACTCCATCAGCATCACCTCCCACTACAAACCCCCTGACTGCTC
AGTGCTGAGTAAGAAGGGAGATTACCTCAAATATCACTACAATGCCTCACTTCTGGATGGGACCCTGCTGGACTCCACGAGCCGGGTGTG
GGCTGAGCCCTGCCTGATTGATGCTGCCAAGGAGGAGTACAACGGGGTGATAGAAGAATTTTTGGCAACAGGAGAGAAGCTTTTTGGACC
TTATGTTTGGGGAAGGTATGACTTGCTCTTCATGCCACCGTCCTTTCCATTTGGAGGAATGGAGAACCCTTGTCTGACCTTTGTCACCCC
CTGCCTGCTAGCTGGGGACCGCTCCTTGGCAGATGTCATCATCCATGAGATCTCCCACAGTTGGTTTGGGAACCTGGTCACCAACGCCAA
CTGGGGTGAATTCTGGCTCAATGAAGGTTTCACCATGTACGCCCAGAGGAGGATCTCCACCATCCTCTTTGGCGCTGCGTACACCTGCTT
GGAGGCTGCAACGGGGCGGGCTCTGCTGCGTCAGCACATGGACATCACTGGAGAGGAAAACCCACTCAACAAGCTCCGCGTGAAGATTGA
ACCAGGCGTTGACCCGGACGACACCTATAATGAGACCCCCTACGAGAAAGGTTTCTGCTTTGTTTCATACCTGGCCCACTTGGTGGGTGA
TCAGGATCAGTTTGACAGTTTTCTCAAGGCCTATGTGCATGAATTCAAATTCCGAAGCATCTTAGCCGATGACTTTCTGGACTTCTACTT
GGAATATTTCCCTGAGCTTAAGAAAAAGAGAGTGGATATCATTCCAGGTTTTGAGTTTGATCGATGGCTGAATACCCCCGGCTGGCCCCC
GTACCTCCCTGATCTCTCCCCTGGGGACTCACTCATGAAGCCTGCTGAAGAGCTAGCCCAACTGTGGGCAGCCGAGGAGCTGGACATGAA
GGCCATTGAAGCCGTGGCCATCTCTCCCTGGAAGACCTACCAGCTGGTCTACTTCCTGGATAAGATCCTCCAGAAATCCCCTCTCCCTCC
TGGGAATGTGAAAAAACTTGGAGACACATACCCAAGTATCTCAAATGCCCGGAATGCAGAGCTCCGGCTGCGATGGGGCCAAATCGTCCT
TAAGAACGACCACCAGGAAGATTTCTGGAAAGTGAAGGAGTTCCTGCATAACCAGGGGAAGCAGAAGTATACACTTCCGCTGTACCACGC
AATGATGGGTGGCAGTGAGGTGGCCCAGACCCTCGCCAAGGAGACTTTTGCATCCACCGCCTCCCAGCTCCACAGCAATGTTGTCAACTA
TGTCCAGCAGATCGTGGCACCCAAGGGCAGTTAGAGGCTCGTGTGCATGGCCCCTGCCTCTTCAGGCTCTCCAGGCTTTCAGAATAATTG
TTTGTTCCCAAATTCCTGTTCCCTGATCAACTTCCTGGAGTTTATATCCCCTCAGGATAATCTATTCTCTAGCTTAGGTATCTGTGACTC
TTGGGCCTCTGCTCTGGTGGGAACTTACTTCTCTATAGCCCACTGAGCCCCGAGACAGAGAACCTGCCCACAGCTCTCCCCGCTACAGGC
TGCAGGCACTGCAGGGCAGCGGGTATTCTCCTCCCCACCTAAGTCTCTGGGAAGAAGTGGAGAGGACTGATGCTCTTCTTTTTTCTCTTT
CTGTCCTTTTTCTTGCTGATTTTATGCAAAGGGCTGGCATTCTGATTGTTCTTTTTTCAGGTTTAATCCTTATTTTAATAAAGTTTTCAA
GCAAAAATTAAGTTA

>30544_30544_3_FKBP9-RNPEP_FKBP9_chr7_33035961_ENST00000538336_RNPEP_chr1_201965274_ENST00000295640_length(amino acids)=866AA_BP=462
MAFRGWRPPPPPLLLLLLWVTGQAAPVAGLGSDAELQIERRFVPDECPRTVRSGDFVRYHYVGTFPDGQKFDSRYWDTAEDKADKSPCPQ
VRVGVNTSPSCRLKQKGVGIYWKDLQFLVRVQNHGLSYDRDSTFNVFVGKGQLITGMDQALVGMCVNERRFVKIPPKLAYGNEGVSGVIP
PNSVLHFDVLLMDIWNSEDQVQIHTYFKPPSCPRTIQVSDFVRYHYNGTFLDGTLFDSSHNRMKTYDTYVGIGWLIPGMDKGLLGMCVGE
KRIITIPPFLAYGEDGDGKDIPGQASLVFDVALLDLHNPKDSISIENKVVPENCERISQSGDFLRYHYNGTLLDGTLFDSSYSRNRTFDT
YIGQGYVIPGMDEGLLGVCIGEKRRIVVPPHLGYGEEGRGNIPGSAVLVFDIHVIDFHNPSDSISITSHYKPPDCSVLSKKGDYLKYHYN
ASLLDGTLLDSTSRVWAEPCLIDAAKEEYNGVIEEFLATGEKLFGPYVWGRYDLLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVII
HEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRALLRQHMDITGEENPLNKLRVKIEPGVDPDDTYNETPY
EKGFCFVSYLAHLVGDQDQFDSFLKAYVHEFKFRSILADDFLDFYLEYFPELKKKRVDIIPGFEFDRWLNTPGWPPYLPDLSPGDSLMKP
AEELAQLWAAEELDMKAIEAVAISPWKTYQLVYFLDKILQKSPLPPGNVKKLGDTYPSISNARNAELRLRWGQIVLKNDHQEDFWKVKEF
LHNQGKQKYTLPLYHAMMGGSEVAQTLAKETFASTASQLHSNVVNYVQQIVAPKGS

--------------------------------------------------------------
>30544_30544_4_FKBP9-RNPEP_FKBP9_chr7_33035961_ENST00000538443_RNPEP_chr1_201965274_ENST00000295640_length(transcript)=2827nt_BP=1180nt
AGGAGACCCGGTCCACGTTTGCAAACGCAGCCGAACGCCCAGGCCGACCCGTGCCGCCCGAGCGCCGCGCTGCGTCCGCGCCACTCTTCT
CGCCGCCCCGATGGCGTTCCGGGGCTGGAGGCCCCCGCCGCCACCGCTGCTCCTGCTGCTGCTCTGGGTGACCGGGCAGGCAGCGCCCGT
GGCGGGCCTGGGCTCCGACGCGGAGCTGCAGATCGAGCGGCGCTTCGTGCCCGACGAGTGCCCGCGCACCGTGCGCAGCGGCGACTTCGT
GCGCTACCACTACGTGGGGACGTTCCCCGACGGCCAGAAGTTCGACTCCAGCTGGTGTGATCCCCCCCAATTCAGTGCTTCATTTTGATG
TACTTCTGATGGATATTTGGAATTCTGAAGACCAGGTTCAGATTCACACCTATTTCAAGCCCCCGAGTTGCCCTCGGACCATCCAGGTGT
CTGATTTTGTGAGGTACCACTACAACGGGACGTTCCTGGACGGAACTCTGTTTGATTCGAGTCACAATCGCATGAAAACATATGACACGT
ATGTGGGAATTGGCTGGCTGATTCCTGGAATGGATAAAGGGCTGCTGGGGATGTGTGTGGGTGAGAAGCGCATCATCACCATTCCTCCTT
TTCTGGCCTATGGAGAGGATGGAGATGGGAAAGACATTCCCGGTCAGGCATCTCTGGTGTTTGATGTTGCATTATTGGACCTCCATAACC
CCAAGGACAGCATTTCCATTGAGAACAAGGTAGTACCTGAAAACTGTGAGCGGATAAGTCAAAGTGGGGACTTTCTCAGGTATCATTACA
ATGGCACGCTTCTGGATGGCACCCTCTTTGATTCCAGCTACTCTCGGAACCGCACGTTTGACACGTACATTGGGCAGGGCTACGTGATTC
CTGGGATGGATGAAGGTCTACTTGGTGTTTGCATTGGAGAAAAGCGAAGGATTGTGGTCCCGCCTCACCTGGGGTATGGAGAGGAAGGAA
GAGGGAATATCCCCGGCTCGGCTGTGCTGGTGTTTGACATCCATGTGATCGACTTCCACAACCCTTCGGACTCCATCAGCATCACCTCCC
ACTACAAACCCCCTGACTGCTCAGTGCTGAGTAAGAAGGGAGATTACCTCAAATATCACTACAATGCCTCACTTCTGGATGGGACCCTGC
TGGACTCCACGAGCCGGGTGTGGGCTGAGCCCTGCCTGATTGATGCTGCCAAGGAGGAGTACAACGGGGTGATAGAAGAATTTTTGGCAA
CAGGAGAGAAGCTTTTTGGACCTTATGTTTGGGGAAGGTATGACTTGCTCTTCATGCCACCGTCCTTTCCATTTGGAGGAATGGAGAACC
CTTGTCTGACCTTTGTCACCCCCTGCCTGCTAGCTGGGGACCGCTCCTTGGCAGATGTCATCATCCATGAGATCTCCCACAGTTGGTTTG
GGAACCTGGTCACCAACGCCAACTGGGGTGAATTCTGGCTCAATGAAGGTTTCACCATGTACGCCCAGAGGAGGATCTCCACCATCCTCT
TTGGCGCTGCGTACACCTGCTTGGAGGCTGCAACGGGGCGGGCTCTGCTGCGTCAGCACATGGACATCACTGGAGAGGAAAACCCACTCA
ACAAGCTCCGCGTGAAGATTGAACCAGGCGTTGACCCGGACGACACCTATAATGAGACCCCCTACGAGAAAGGTTTCTGCTTTGTTTCAT
ACCTGGCCCACTTGGTGGGTGATCAGGATCAGTTTGACAGTTTTCTCAAGGCCTATGTGCATGAATTCAAATTCCGAAGCATCTTAGCCG
ATGACTTTCTGGACTTCTACTTGGAATATTTCCCTGAGCTTAAGAAAAAGAGAGTGGATATCATTCCAGGTTTTGAGTTTGATCGATGGC
TGAATACCCCCGGCTGGCCCCCGTACCTCCCTGATCTCTCCCCTGGGGACTCACTCATGAAGCCTGCTGAAGAGCTAGCCCAACTGTGGG
CAGCCGAGGAGCTGGACATGAAGGCCATTGAAGCCGTGGCCATCTCTCCCTGGAAGACCTACCAGCTGGTCTACTTCCTGGATAAGATCC
TCCAGAAATCCCCTCTCCCTCCTGGGAATGTGAAAAAACTTGGAGACACATACCCAAGTATCTCAAATGCCCGGAATGCAGAGCTCCGGC
TGCGATGGGGCCAAATCGTCCTTAAGAACGACCACCAGGAAGATTTCTGGAAAGTGAAGGAGTTCCTGCATAACCAGGGGAAGCAGAAGT
ATACACTTCCGCTGTACCACGCAATGATGGGTGGCAGTGAGGTGGCCCAGACCCTCGCCAAGGAGACTTTTGCATCCACCGCCTCCCAGC
TCCACAGCAATGTTGTCAACTATGTCCAGCAGATCGTGGCACCCAAGGGCAGTTAGAGGCTCGTGTGCATGGCCCCTGCCTCTTCAGGCT
CTCCAGGCTTTCAGAATAATTGTTTGTTCCCAAATTCCTGTTCCCTGATCAACTTCCTGGAGTTTATATCCCCTCAGGATAATCTATTCT
CTAGCTTAGGTATCTGTGACTCTTGGGCCTCTGCTCTGGTGGGAACTTACTTCTCTATAGCCCACTGAGCCCCGAGACAGAGAACCTGCC
CACAGCTCTCCCCGCTACAGGCTGCAGGCACTGCAGGGCAGCGGGTATTCTCCTCCCCACCTAAGTCTCTGGGAAGAAGTGGAGAGGACT
GATGCTCTTCTTTTTTCTCTTTCTGTCCTTTTTCTTGCTGATTTTATGCAAAGGGCTGGCATTCTGATTGTTCTTTTTTCAGGTTTAATC
CTTATTTTAATAAAGTTTTCAAGCAAAAATTAAGTTA

>30544_30544_4_FKBP9-RNPEP_FKBP9_chr7_33035961_ENST00000538443_RNPEP_chr1_201965274_ENST00000295640_length(amino acids)=676AA_BP=272
MMDIWNSEDQVQIHTYFKPPSCPRTIQVSDFVRYHYNGTFLDGTLFDSSHNRMKTYDTYVGIGWLIPGMDKGLLGMCVGEKRIITIPPFL
AYGEDGDGKDIPGQASLVFDVALLDLHNPKDSISIENKVVPENCERISQSGDFLRYHYNGTLLDGTLFDSSYSRNRTFDTYIGQGYVIPG
MDEGLLGVCIGEKRRIVVPPHLGYGEEGRGNIPGSAVLVFDIHVIDFHNPSDSISITSHYKPPDCSVLSKKGDYLKYHYNASLLDGTLLD
STSRVWAEPCLIDAAKEEYNGVIEEFLATGEKLFGPYVWGRYDLLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGN
LVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRALLRQHMDITGEENPLNKLRVKIEPGVDPDDTYNETPYEKGFCFVSYL
AHLVGDQDQFDSFLKAYVHEFKFRSILADDFLDFYLEYFPELKKKRVDIIPGFEFDRWLNTPGWPPYLPDLSPGDSLMKPAEELAQLWAA
EELDMKAIEAVAISPWKTYQLVYFLDKILQKSPLPPGNVKKLGDTYPSISNARNAELRLRWGQIVLKNDHQEDFWKVKEFLHNQGKQKYT
LPLYHAMMGGSEVAQTLAKETFASTASQLHSNVVNYVQQIVAPKGS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FKBP9-RNPEP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FKBP9-RNPEP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FKBP9-RNPEP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0024668Mammary Neoplasms, Experimental1CTD_human