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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACOT7-TTC34 (FusionGDB2 ID:HG11332TG100287898)

Fusion Gene Summary for ACOT7-TTC34

check button Fusion gene summary
Fusion gene informationFusion gene name: ACOT7-TTC34
Fusion gene ID: hg11332tg100287898
HgeneTgene
Gene symbol

ACOT7

TTC34

Gene ID

11332

100287898

Gene nameacyl-CoA thioesterase 7tetratricopeptide repeat domain 34
SynonymsACH1|ACT|BACH|CTE-II|LACH|LACH1|hBACH-
Cytomap('ACOT7')('TTC34')

1p36.31

1p36.32

Type of geneprotein-codingprotein-coding
Descriptioncytosolic acyl coenzyme A thioester hydrolaseCTE-IIaacyl-CoA thioesterase 2acyl-CoA thioesterase, long chainbrain acyl-CoA hydrolaselong chain acyl-CoA thioester hydrolasetetratricopeptide repeat protein 34TPR repeat protein 34TPR repeat-containing protein ENSP00000383873
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000545482, ENST00000361521, 
ENST00000608083, ENST00000377842, 
ENST00000377845, ENST00000377855, 
ENST00000541130, 
Fusion gene scores* DoF score15 X 10 X 10=15004 X 2 X 6=48
# samples 206
** MAII scorelog2(20/1500*10)=-2.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ACOT7 [Title/Abstract] AND TTC34 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACOT7(6453317)-TTC34(2577002), # samples:3
Anticipated loss of major functional domain due to fusion event.ACOT7-TTC34 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACOT7-TTC34 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACOT7

GO:0015937

coenzyme A biosynthetic process

10578051

HgeneACOT7

GO:0036114

medium-chain fatty-acyl-CoA catabolic process

10578051

HgeneACOT7

GO:0036116

long-chain fatty-acyl-CoA catabolic process

10578051

HgeneACOT7

GO:0051792

medium-chain fatty acid biosynthetic process

10578051

HgeneACOT7

GO:1900535

palmitic acid biosynthetic process

10578051


check buttonFusion gene breakpoints across ACOT7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TTC34 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A04W-01AACOT7chr1

6453317

-TTC34chr1

2577002

-


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Fusion Gene ORF analysis for ACOT7-TTC34

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000545482ENST00000401094ACOT7chr1

6453317

-TTC34chr1

2577002

-
5UTR-3CDSENST00000545482ENST00000401095ACOT7chr1

6453317

-TTC34chr1

2577002

-
In-frameENST00000361521ENST00000401094ACOT7chr1

6453317

-TTC34chr1

2577002

-
In-frameENST00000361521ENST00000401095ACOT7chr1

6453317

-TTC34chr1

2577002

-
In-frameENST00000608083ENST00000401094ACOT7chr1

6453317

-TTC34chr1

2577002

-
In-frameENST00000608083ENST00000401095ACOT7chr1

6453317

-TTC34chr1

2577002

-
intron-3CDSENST00000377842ENST00000401094ACOT7chr1

6453317

-TTC34chr1

2577002

-
intron-3CDSENST00000377842ENST00000401095ACOT7chr1

6453317

-TTC34chr1

2577002

-
intron-3CDSENST00000377845ENST00000401094ACOT7chr1

6453317

-TTC34chr1

2577002

-
intron-3CDSENST00000377845ENST00000401095ACOT7chr1

6453317

-TTC34chr1

2577002

-
intron-3CDSENST00000377855ENST00000401094ACOT7chr1

6453317

-TTC34chr1

2577002

-
intron-3CDSENST00000377855ENST00000401095ACOT7chr1

6453317

-TTC34chr1

2577002

-
intron-3CDSENST00000541130ENST00000401094ACOT7chr1

6453317

-TTC34chr1

2577002

-
intron-3CDSENST00000541130ENST00000401095ACOT7chr1

6453317

-TTC34chr1

2577002

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000608083ACOT7chr16453317-ENST00000401094TTC34chr12577002-180310591118369
ENST00000608083ACOT7chr16453317-ENST00000401095TTC34chr12577002-111910591118369
ENST00000361521ACOT7chr16453317-ENST00000401094TTC34chr12577002-283311354662148560
ENST00000361521ACOT7chr16453317-ENST00000401095TTC34chr12577002-214911354662148561

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000608083ENST00000401094ACOT7chr16453317-TTC34chr12577002-0.0502480270.9497519
ENST00000608083ENST00000401095ACOT7chr16453317-TTC34chr12577002-0.018544750.98145527
ENST00000361521ENST00000401094ACOT7chr16453317-TTC34chr12577002-0.161542280.83845776
ENST00000361521ENST00000401095ACOT7chr16453317-TTC34chr12577002-0.143282650.85671735

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Fusion Genomic Features for ACOT7-TTC34


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ACOT7-TTC34


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:6453317/chr1:2577002)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTTC34chr1:6453317chr1:2577002ENST0000040109537306_339229567.0RepeatNote=TPR 4
TgeneTTC34chr1:6453317chr1:2577002ENST0000040109537341_373229567.0RepeatNote=TPR 5
TgeneTTC34chr1:6453317chr1:2577002ENST0000040109537424_457229567.0RepeatNote=TPR 6
TgeneTTC34chr1:6453317chr1:2577002ENST0000040109537464_497229567.0RepeatNote=TPR 7
TgeneTTC34chr1:6453317chr1:2577002ENST0000040109537512_545229567.0RepeatNote=TPR 8

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACOT7chr1:6453317chr1:2577002ENST00000361521-19224_33847371.0DomainHotDog ACOT-type 2
HgeneACOT7chr1:6453317chr1:2577002ENST00000361521-1950_16847371.0DomainHotDog ACOT-type 1
HgeneACOT7chr1:6453317chr1:2577002ENST00000377842-19224_3380330.0DomainHotDog ACOT-type 2
HgeneACOT7chr1:6453317chr1:2577002ENST00000377842-1950_1680330.0DomainHotDog ACOT-type 1
HgeneACOT7chr1:6453317chr1:2577002ENST00000377845-19224_3380351.0DomainHotDog ACOT-type 2
HgeneACOT7chr1:6453317chr1:2577002ENST00000377845-1950_1680351.0DomainHotDog ACOT-type 1
HgeneACOT7chr1:6453317chr1:2577002ENST00000377855-19224_3380381.0DomainHotDog ACOT-type 2
HgeneACOT7chr1:6453317chr1:2577002ENST00000377855-1950_1680381.0DomainHotDog ACOT-type 1
TgeneTTC34chr1:6453317chr1:2577002ENST0000040109537178_211229567.0RepeatNote=TPR 2
TgeneTTC34chr1:6453317chr1:2577002ENST0000040109537212_245229567.0RepeatNote=TPR 3
TgeneTTC34chr1:6453317chr1:2577002ENST000004010953750_83229567.0RepeatNote=TPR 1


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Fusion Gene Sequence for ACOT7-TTC34


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1389_1389_1_ACOT7-TTC34_ACOT7_chr1_6453317_ENST00000361521_TTC34_chr1_2577002_ENST00000401094_length(transcript)=2833nt_BP=1135nt
GCCGGAGTTGCGTGGGTTTTAATTTAAAGATGTAAGTACAAATCTATGTGCATTGTAGAAAATTCGGAAAAGGTCCAACTGCCTAGCAAG
TAAAAAGCTGTCATTCCAGCACGTGGGGGGTGACCGCTTCTCCCTTCTTGGGTGTTTTTTGGTGGATTTTTTTTGGTGACCCCGACTGGC
CTAGACTCCATTCAAGGGCACATCTTGTGCAGTAAAACACGCATGTTTCAGGGCTCCTCACTGCAACACGTGCACCTCCAGGCTGGCGCT
CAGCGCTCCCAGTAAAAGCTGCAGGCGGCGGTGTAGATAGTCGCCGGCCTTTCCTCCTCCCCACCTCGTGACGCTTTGTGCTGCGGAAGC
AAAGGCCCGTTCCATTCCCCGTGTCTTCCCAGCAGCCGCCACCAATGCTCCTTTCTAGGAAACAGCCTTCCATTCTCTCTTAGGGCCGAT
CTTAGCGAGAGCCGCGATGCGGGCGACTGGTGCCGGGGTGGGTTGGGGGCGGGGGTGGGAATCAGGCCCCACTGCCAGGAGCCCGGGCCG
CGCCTTCCGCTCTGACCTCATCCGGCCGCCCAGGCACTGGGCGCGGCAGCGAATCGGCGGCGCGGGCGGCCGGGAACGCCCAGCACAAAT
ATTTACCGCCGCGCGGAGAGTGAGGGCCCAAGTCCGCCCTGCTCCGCCACTTAGGCCGCCCCAGACGCTTCCCTCGGGGCTGCCACCGGG
TCGGGCGCGGCTGCCGCGGCTAGCGGGCCTTCCCCGCACCGGCGCGGCCCAACCGCCACCGAACCTTCTGGAAGCGGCGGCTGCCTGGGC
CCCCACGCCGCCAGAATCGTACGCCCGCGCGAGCTCTCTGCAGCCTTGGCGGCCTGGGAGGCGGGGCTCGGGGTGGGGCCGGCGCGGGGG
CGGGGTCGGCGCGGGGAGGCCGCGTTCGATTGCCCCCGGCGCGCAGGCCCCGCCTCACCAGCCCCATCGCTCCACCTCTGCCCTCCCCCT
TTATGGCGCGGCCCGGGCTCATTCATTCCGCGCCGGGCCTGCCAGACACCTGCGCCCTTCTGCAGCCGCCCGCCGCATCCGCCGCCGCAG
CCCCCAGCATGTCGGGCCCAGACGTCGAGACGCCGTCCGCCATCCAGATCTGCCGGAAGCCGTGGACGACATCGTCTCTGCTCTGAAGCT
CGGCCCCGGGACTGTGGTCCCTGAGCTCCGCTCTCTGAAGCCGGAAGCCCAGGCCCTCATCACACAGGGCCTCTACTCCCACTGCCGGGC
CCTTCTGAGCCAGCTGCCAGACACTGGGGCCCCTCTCGAGGACAAGGACACCCAGGGCCTCCTTGCTGTGGGGGAGGCGCTGATCAAAAT
CGACTCAGGGCAACCGCACTGGCACCTCCTCCTGGCAGACATTCTCATGGCACAGGGCAGCTACGAGGAAGCTGGCACCCACCTGGAAAA
AGCCCTGCACCGTGCCCCAACGTCAGAGGCAGCCCGGGCCCGGCTGGGCCTGCTCCAGCTCAAGAAGGGAGACGTGCCAGGGGCTGCAAG
GGACCTGCAGAGCCTGGCCGAGGTGGATGCCCCGGATCTCAGCTGCCTGCTGCATCTCCTGGAGGCCTCGGAGCGGCAGAGCCTTGCCCA
GGCGGCGGCCCAGGAAGCCGGCACCCTCCTGGACGCAGGGCAACCCAGGCAGGCGCTGGGCTACTGTTCGCTGTCTGTCCTGGCCAGTGG
CAGCAGTGCCTGTCACCTGCGTCTGCGGGCCACCTGCCTGGCCGAGTTGCAGGAGTTTGGCCGGGCCCTTAGGGACCTGGACCATGTGCT
CCAGGAGGCGCTGGGGGATGGTGACCTCCCAAGGCGGGCAGAGGACTTCTGCCGTCAGGGTCGCCTGCTGCTGAGCCTGGGGGATGAGGC
GGCGGCCGCAGGGGCCTTTGCCCAGGCCCTGAAGCTGGCGCCCTCCTTGGCCCAGAACAGCCTGTGCAGGCAGCCAGGCCGGGCCCCCAC
TGCACGCATGTTCCTTCTCCGCGGGCAGTGCTGCCTGGAGGAGCAGCGTCACGCAGAGGCCTGGACGGCGGTAGAGAGCGGCCTCCTGGT
GGACCCCGACCACCGTGGCCTGAAGAGACTGAAGGCCAGAATCCGGAGGGAGGCATCCTCAGGCTGCTGGCTACAGTGACTGGGCCTGAC
CCTCTCCCAGCCCTAATCACGGGGGCCACGACCCCCCCTCCTGGCTTCTCTCTCCTCCTGGGCACTTGCATTTGTCCCATTTCTCTCTAG
GGAATCATGGAGGTTGCAACCACAAAATTCAGAGAGGTGACCTGGCTGGCGACACTGGTGATAATGGTCACCTGCCATGCAGCCTTTCAG
CTCAGGTGGGCACACTCCTCTGCCCCTGCCCACTTCCTCTCCCAGGTGAATCTTGACCACACCTGTGCCTGGCACTGTGCACACATTCTC
TGTTGTTCAACTCTGCGATCAATCTGGAAAAAAAAGAAAAAAAAAAAACCTTTTTAGGAGAGTAAAAGGAAAATAAATCTTGGGGCCCCA
AAATCACTAAGCCAAAGGGAAAAGTCAAGCTGGGAACTGCTTAGGGCAAGCCTGCCTCCAATTCCATTCAAAGTCATTCCCCCGCTCGCT
GAGATAGATGCATATCTGATTGCCTTCTTTGGAAAGGCTCATCAGAAACTCAAAAGAATGTAACTCTATCTTACATGTGTTGATTGATGT
CTCATATCTCCCTAAAATGTATAAAACCAAGCTGTCCTCTGACCACCTTGGGCACATGTCAGGACCTCCTGAGGCTGTGTCACAGGTGTG

>1389_1389_1_ACOT7-TTC34_ACOT7_chr1_6453317_ENST00000361521_TTC34_chr1_2577002_ENST00000401094_length(amino acids)=560AA_BP=136
MRATGAGVGWGRGWESGPTARSPGRAFRSDLIRPPRHWARQRIGGAGGRERPAQIFTAARRVRAQVRPAPPLRPPQTLPSGLPPGRARLP
RLAGLPRTGAAQPPPNLLEAAAAWAPTPPESYARASSLQPWRPGRRGSGWGRRGGGVGAGRPRSIAPGAQAPPHQPHRSTSALPLYGAAR
AHSFRAGPARHLRPSAAARRIRRRSPQHVGPRRRDAVRHPDLPEAVDDIVSALKLGPGTVVPELRSLKPEAQALITQGLYSHCRALLSQL
PDTGAPLEDKDTQGLLAVGEALIKIDSGQPHWHLLLADILMAQGSYEEAGTHLEKALHRAPTSEAARARLGLLQLKKGDVPGAARDLQSL
AEVDAPDLSCLLHLLEASERQSLAQAAAQEAGTLLDAGQPRQALGYCSLSVLASGSSACHLRLRATCLAELQEFGRALRDLDHVLQEALG
DGDLPRRAEDFCRQGRLLLSLGDEAAAAGAFAQALKLAPSLAQNSLCRQPGRAPTARMFLLRGQCCLEEQRHAEAWTAVESGLLVDPDHR

--------------------------------------------------------------
>1389_1389_2_ACOT7-TTC34_ACOT7_chr1_6453317_ENST00000361521_TTC34_chr1_2577002_ENST00000401095_length(transcript)=2149nt_BP=1135nt
GCCGGAGTTGCGTGGGTTTTAATTTAAAGATGTAAGTACAAATCTATGTGCATTGTAGAAAATTCGGAAAAGGTCCAACTGCCTAGCAAG
TAAAAAGCTGTCATTCCAGCACGTGGGGGGTGACCGCTTCTCCCTTCTTGGGTGTTTTTTGGTGGATTTTTTTTGGTGACCCCGACTGGC
CTAGACTCCATTCAAGGGCACATCTTGTGCAGTAAAACACGCATGTTTCAGGGCTCCTCACTGCAACACGTGCACCTCCAGGCTGGCGCT
CAGCGCTCCCAGTAAAAGCTGCAGGCGGCGGTGTAGATAGTCGCCGGCCTTTCCTCCTCCCCACCTCGTGACGCTTTGTGCTGCGGAAGC
AAAGGCCCGTTCCATTCCCCGTGTCTTCCCAGCAGCCGCCACCAATGCTCCTTTCTAGGAAACAGCCTTCCATTCTCTCTTAGGGCCGAT
CTTAGCGAGAGCCGCGATGCGGGCGACTGGTGCCGGGGTGGGTTGGGGGCGGGGGTGGGAATCAGGCCCCACTGCCAGGAGCCCGGGCCG
CGCCTTCCGCTCTGACCTCATCCGGCCGCCCAGGCACTGGGCGCGGCAGCGAATCGGCGGCGCGGGCGGCCGGGAACGCCCAGCACAAAT
ATTTACCGCCGCGCGGAGAGTGAGGGCCCAAGTCCGCCCTGCTCCGCCACTTAGGCCGCCCCAGACGCTTCCCTCGGGGCTGCCACCGGG
TCGGGCGCGGCTGCCGCGGCTAGCGGGCCTTCCCCGCACCGGCGCGGCCCAACCGCCACCGAACCTTCTGGAAGCGGCGGCTGCCTGGGC
CCCCACGCCGCCAGAATCGTACGCCCGCGCGAGCTCTCTGCAGCCTTGGCGGCCTGGGAGGCGGGGCTCGGGGTGGGGCCGGCGCGGGGG
CGGGGTCGGCGCGGGGAGGCCGCGTTCGATTGCCCCCGGCGCGCAGGCCCCGCCTCACCAGCCCCATCGCTCCACCTCTGCCCTCCCCCT
TTATGGCGCGGCCCGGGCTCATTCATTCCGCGCCGGGCCTGCCAGACACCTGCGCCCTTCTGCAGCCGCCCGCCGCATCCGCCGCCGCAG
CCCCCAGCATGTCGGGCCCAGACGTCGAGACGCCGTCCGCCATCCAGATCTGCCGGAAGCCGTGGACGACATCGTCTCTGCTCTGAAGCT
CGGCCCCGGGACTGTGGTCCCTGAGCTCCGCTCTCTGAAGCCGGAAGCCCAGGCCCTCATCACACAGGGCCTCTACTCCCACTGCCGGGC
CCTTCTGAGCCAGCTGCCAGACACTGGGGCCCCTCTCGAGGACAAGGACACCCAGGGCCTCCTTGCTGTGGGGGAGGCGCTGATCAAAAT
CGACTCAGGGCAACCGCACTGGCACCTCCTCCTGGCAGACATTCTCATGGCACAGGGCAGCTACGAGGAAGCTGGCACCCACCTGGAAAA
AGCCCTGCACCGTGCCCCAACGTCAGAGGCAGCCCGGGCCCGGCTGGGCCTGCTCCAGCTCAAGAAGGGAGACGTGCCAGGGGCTGCAAG
GGACCTGCAGAGCCTGGCCGAGGTGGATGCCCCGGATCTCAGCTGCCTGCTGCATCTCCTGGAGGCCTCGGAGCGGCAGAGCCTTGCCCA
GGCGGCGGCCCAGGAAGCCGGCACCCTCCTGGACGCAGGGCAACCCAGGCAGGCGCTGGGCTACTGTTCGCTGTCTGTCCTGGCCAGTGG
CAGCAGTGCCTGTCACCTGCGTCTGCGGGCCACCTGCCTGGCCGAGTTGCAGGAGTTTGGCCGGGCCCTTAGGGACCTGGACCATGTGCT
CCAGGAGGCGCTGGGGGATGGTGACCTCCCAAGGCGGGCAGAGGACTTCTGCCGTCAGGGTCGCCTGCTGCTGAGCCTGGGGGATGAGGC
GGCGGCCGCAGGGGCCTTTGCCCAGGCCCTGAAGCTGGCGCCCTCCTTGGCCCAGAACAGCCTGTGCAGGCAGCCAGGCCGGGCCCCCAC
TGCACGCATGTTCCTTCTCCGCGGGCAGTGCTGCCTGGAGGAGCAGCGTCACGCAGAGGCCTGGACGGCGGTAGAGAGCGGCCTCCTGGT

>1389_1389_2_ACOT7-TTC34_ACOT7_chr1_6453317_ENST00000361521_TTC34_chr1_2577002_ENST00000401095_length(amino acids)=561AA_BP=136
MRATGAGVGWGRGWESGPTARSPGRAFRSDLIRPPRHWARQRIGGAGGRERPAQIFTAARRVRAQVRPAPPLRPPQTLPSGLPPGRARLP
RLAGLPRTGAAQPPPNLLEAAAAWAPTPPESYARASSLQPWRPGRRGSGWGRRGGGVGAGRPRSIAPGAQAPPHQPHRSTSALPLYGAAR
AHSFRAGPARHLRPSAAARRIRRRSPQHVGPRRRDAVRHPDLPEAVDDIVSALKLGPGTVVPELRSLKPEAQALITQGLYSHCRALLSQL
PDTGAPLEDKDTQGLLAVGEALIKIDSGQPHWHLLLADILMAQGSYEEAGTHLEKALHRAPTSEAARARLGLLQLKKGDVPGAARDLQSL
AEVDAPDLSCLLHLLEASERQSLAQAAAQEAGTLLDAGQPRQALGYCSLSVLASGSSACHLRLRATCLAELQEFGRALRDLDHVLQEALG
DGDLPRRAEDFCRQGRLLLSLGDEAAAAGAFAQALKLAPSLAQNSLCRQPGRAPTARMFLLRGQCCLEEQRHAEAWTAVESGLLVDPDHR

--------------------------------------------------------------
>1389_1389_3_ACOT7-TTC34_ACOT7_chr1_6453317_ENST00000608083_TTC34_chr1_2577002_ENST00000401094_length(transcript)=1803nt_BP=105nt
GCCAGACACCTGCGCCCTTCTGCAGCCGCCCGCCGCATCCGCCGCCGCAGCCCCCAGCATGTCGGGCCCAGACGTCGAGACGCCGTCCGC
CATCCAGATCTGCCGGAAGCCGTGGACGACATCGTCTCTGCTCTGAAGCTCGGCCCCGGGACTGTGGTCCCTGAGCTCCGCTCTCTGAAG
CCGGAAGCCCAGGCCCTCATCACACAGGGCCTCTACTCCCACTGCCGGGCCCTTCTGAGCCAGCTGCCAGACACTGGGGCCCCTCTCGAG
GACAAGGACACCCAGGGCCTCCTTGCTGTGGGGGAGGCGCTGATCAAAATCGACTCAGGGCAACCGCACTGGCACCTCCTCCTGGCAGAC
ATTCTCATGGCACAGGGCAGCTACGAGGAAGCTGGCACCCACCTGGAAAAAGCCCTGCACCGTGCCCCAACGTCAGAGGCAGCCCGGGCC
CGGCTGGGCCTGCTCCAGCTCAAGAAGGGAGACGTGCCAGGGGCTGCAAGGGACCTGCAGAGCCTGGCCGAGGTGGATGCCCCGGATCTC
AGCTGCCTGCTGCATCTCCTGGAGGCCTCGGAGCGGCAGAGCCTTGCCCAGGCGGCGGCCCAGGAAGCCGGCACCCTCCTGGACGCAGGG
CAACCCAGGCAGGCGCTGGGCTACTGTTCGCTGTCTGTCCTGGCCAGTGGCAGCAGTGCCTGTCACCTGCGTCTGCGGGCCACCTGCCTG
GCCGAGTTGCAGGAGTTTGGCCGGGCCCTTAGGGACCTGGACCATGTGCTCCAGGAGGCGCTGGGGGATGGTGACCTCCCAAGGCGGGCA
GAGGACTTCTGCCGTCAGGGTCGCCTGCTGCTGAGCCTGGGGGATGAGGCGGCGGCCGCAGGGGCCTTTGCCCAGGCCCTGAAGCTGGCG
CCCTCCTTGGCCCAGAACAGCCTGTGCAGGCAGCCAGGCCGGGCCCCCACTGCACGCATGTTCCTTCTCCGCGGGCAGTGCTGCCTGGAG
GAGCAGCGTCACGCAGAGGCCTGGACGGCGGTAGAGAGCGGCCTCCTGGTGGACCCCGACCACCGTGGCCTGAAGAGACTGAAGGCCAGA
ATCCGGAGGGAGGCATCCTCAGGCTGCTGGCTACAGTGACTGGGCCTGACCCTCTCCCAGCCCTAATCACGGGGGCCACGACCCCCCCTC
CTGGCTTCTCTCTCCTCCTGGGCACTTGCATTTGTCCCATTTCTCTCTAGGGAATCATGGAGGTTGCAACCACAAAATTCAGAGAGGTGA
CCTGGCTGGCGACACTGGTGATAATGGTCACCTGCCATGCAGCCTTTCAGCTCAGGTGGGCACACTCCTCTGCCCCTGCCCACTTCCTCT
CCCAGGTGAATCTTGACCACACCTGTGCCTGGCACTGTGCACACATTCTCTGTTGTTCAACTCTGCGATCAATCTGGAAAAAAAAGAAAA
AAAAAAAACCTTTTTAGGAGAGTAAAAGGAAAATAAATCTTGGGGCCCCAAAATCACTAAGCCAAAGGGAAAAGTCAAGCTGGGAACTGC
TTAGGGCAAGCCTGCCTCCAATTCCATTCAAAGTCATTCCCCCGCTCGCTGAGATAGATGCATATCTGATTGCCTTCTTTGGAAAGGCTC
ATCAGAAACTCAAAAGAATGTAACTCTATCTTACATGTGTTGATTGATGTCTCATATCTCCCTAAAATGTATAAAACCAAGCTGTCCTCT
GACCACCTTGGGCACATGTCAGGACCTCCTGAGGCTGTGTCACAGGTGTGCATCCTTAATTTTGGCAAAATAAACTTCCCAAATTGGCTG

>1389_1389_3_ACOT7-TTC34_ACOT7_chr1_6453317_ENST00000608083_TTC34_chr1_2577002_ENST00000401094_length(amino acids)=369AA_BP=26
MRPSAAARRIRRRSPQHVGPRRRDAVRHPDLPEAVDDIVSALKLGPGTVVPELRSLKPEAQALITQGLYSHCRALLSQLPDTGAPLEDKD
TQGLLAVGEALIKIDSGQPHWHLLLADILMAQGSYEEAGTHLEKALHRAPTSEAARARLGLLQLKKGDVPGAARDLQSLAEVDAPDLSCL
LHLLEASERQSLAQAAAQEAGTLLDAGQPRQALGYCSLSVLASGSSACHLRLRATCLAELQEFGRALRDLDHVLQEALGDGDLPRRAEDF
CRQGRLLLSLGDEAAAAGAFAQALKLAPSLAQNSLCRQPGRAPTARMFLLRGQCCLEEQRHAEAWTAVESGLLVDPDHRGLKRLKARIRR

--------------------------------------------------------------
>1389_1389_4_ACOT7-TTC34_ACOT7_chr1_6453317_ENST00000608083_TTC34_chr1_2577002_ENST00000401095_length(transcript)=1119nt_BP=105nt
GCCAGACACCTGCGCCCTTCTGCAGCCGCCCGCCGCATCCGCCGCCGCAGCCCCCAGCATGTCGGGCCCAGACGTCGAGACGCCGTCCGC
CATCCAGATCTGCCGGAAGCCGTGGACGACATCGTCTCTGCTCTGAAGCTCGGCCCCGGGACTGTGGTCCCTGAGCTCCGCTCTCTGAAG
CCGGAAGCCCAGGCCCTCATCACACAGGGCCTCTACTCCCACTGCCGGGCCCTTCTGAGCCAGCTGCCAGACACTGGGGCCCCTCTCGAG
GACAAGGACACCCAGGGCCTCCTTGCTGTGGGGGAGGCGCTGATCAAAATCGACTCAGGGCAACCGCACTGGCACCTCCTCCTGGCAGAC
ATTCTCATGGCACAGGGCAGCTACGAGGAAGCTGGCACCCACCTGGAAAAAGCCCTGCACCGTGCCCCAACGTCAGAGGCAGCCCGGGCC
CGGCTGGGCCTGCTCCAGCTCAAGAAGGGAGACGTGCCAGGGGCTGCAAGGGACCTGCAGAGCCTGGCCGAGGTGGATGCCCCGGATCTC
AGCTGCCTGCTGCATCTCCTGGAGGCCTCGGAGCGGCAGAGCCTTGCCCAGGCGGCGGCCCAGGAAGCCGGCACCCTCCTGGACGCAGGG
CAACCCAGGCAGGCGCTGGGCTACTGTTCGCTGTCTGTCCTGGCCAGTGGCAGCAGTGCCTGTCACCTGCGTCTGCGGGCCACCTGCCTG
GCCGAGTTGCAGGAGTTTGGCCGGGCCCTTAGGGACCTGGACCATGTGCTCCAGGAGGCGCTGGGGGATGGTGACCTCCCAAGGCGGGCA
GAGGACTTCTGCCGTCAGGGTCGCCTGCTGCTGAGCCTGGGGGATGAGGCGGCGGCCGCAGGGGCCTTTGCCCAGGCCCTGAAGCTGGCG
CCCTCCTTGGCCCAGAACAGCCTGTGCAGGCAGCCAGGCCGGGCCCCCACTGCACGCATGTTCCTTCTCCGCGGGCAGTGCTGCCTGGAG
GAGCAGCGTCACGCAGAGGCCTGGACGGCGGTAGAGAGCGGCCTCCTGGTGGACCCCGACCACCGTGGCCTGAAGAGACTGAAGGCCAGA

>1389_1389_4_ACOT7-TTC34_ACOT7_chr1_6453317_ENST00000608083_TTC34_chr1_2577002_ENST00000401095_length(amino acids)=369AA_BP=26
MRPSAAARRIRRRSPQHVGPRRRDAVRHPDLPEAVDDIVSALKLGPGTVVPELRSLKPEAQALITQGLYSHCRALLSQLPDTGAPLEDKD
TQGLLAVGEALIKIDSGQPHWHLLLADILMAQGSYEEAGTHLEKALHRAPTSEAARARLGLLQLKKGDVPGAARDLQSLAEVDAPDLSCL
LHLLEASERQSLAQAAAQEAGTLLDAGQPRQALGYCSLSVLASGSSACHLRLRATCLAELQEFGRALRDLDHVLQEALGDGDLPRRAEDF
CRQGRLLLSLGDEAAAAGAFAQALKLAPSLAQNSLCRQPGRAPTARMFLLRGQCCLEEQRHAEAWTAVESGLLVDPDHRGLKRLKARIRR

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Fusion Gene PPI Analysis for ACOT7-TTC34


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACOT7-TTC34


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACOT7-TTC34


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource