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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACOT7-RPL22 (FusionGDB2 ID:HG11332TG6146)

Fusion Gene Summary for ACOT7-RPL22

check button Fusion gene summary
Fusion gene informationFusion gene name: ACOT7-RPL22
Fusion gene ID: hg11332tg6146
HgeneTgene
Gene symbol

ACOT7

RPL22

Gene ID

11332

6146

Gene nameacyl-CoA thioesterase 7ribosomal protein L22
SynonymsACH1|ACT|BACH|CTE-II|LACH|LACH1|hBACHEAP|HBP15|HBP15/L22|L22
Cytomap('ACOT7')('RPL22')

1p36.31

1p36.31

Type of geneprotein-codingprotein-coding
Descriptioncytosolic acyl coenzyme A thioester hydrolaseCTE-IIaacyl-CoA thioesterase 2acyl-CoA thioesterase, long chainbrain acyl-CoA hydrolaselong chain acyl-CoA thioester hydrolase60S ribosomal protein L22EBER-associated proteinEpstein-Barr virus small RNA-associated proteinEpstein-Barr-encoded RNA-associated proteinheparin-binding protein 15heparin-binding protein HBp15large ribosomal subunit protein eL22
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000361521, ENST00000377842, 
ENST00000377845, ENST00000377855, 
ENST00000541130, ENST00000545482, 
ENST00000608083, 		ENST00000541130, 
ENST00000361521, ENST00000377842, 
ENST00000377845, ENST00000377855, 
ENST00000608083, ENST00000545482, 
Fusion gene scores* DoF score15 X 10 X 10=150011 X 8 X 6=528
# samples 2012
** MAII scorelog2(20/1500*10)=-2.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/528*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACOT7 [Title/Abstract] AND RPL22 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACOT7(6387358)-RPL22(6253114), # samples:1
ACOT7(6387358)-RPL22(6246876), # samples:1
Anticipated loss of major functional domain due to fusion event.ACOT7-RPL22 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACOT7-RPL22 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACOT7-RPL22 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACOT7-RPL22 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RPL22-ACOT7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RPL22-ACOT7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACOT7-RPL22 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ACOT7-RPL22 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
ACOT7-RPL22 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
RPL22-ACOT7 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
RPL22-ACOT7 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
RPL22-ACOT7 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACOT7

GO:0015937

coenzyme A biosynthetic process

10578051

HgeneACOT7

GO:0036114

medium-chain fatty-acyl-CoA catabolic process

10578051

HgeneACOT7

GO:0036116

long-chain fatty-acyl-CoA catabolic process

10578051

HgeneACOT7

GO:0051792

medium-chain fatty acid biosynthetic process

10578051

HgeneACOT7

GO:1900535

palmitic acid biosynthetic process

10578051


check buttonFusion gene breakpoints across ACOT7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RPL22 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0FTACOT7chr1

6387358

-RPL22chr1

6253114

-
ChimerDB4LGGTCGA-DU-A5TTACOT7chr1

6387358

-RPL22chr1

6246876

-


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Fusion Gene ORF analysis for ACOT7-RPL22

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000361521ENST00000234875ACOT7chr1

6387358

-RPL22chr1

6246876

-
5CDS-intronENST00000361521ENST00000484532ACOT7chr1

6387358

-RPL22chr1

6246876

-
5CDS-intronENST00000361521ENST00000497965ACOT7chr1

6387358

-RPL22chr1

6246876

-
5CDS-intronENST00000377842ENST00000234875ACOT7chr1

6387358

-RPL22chr1

6246876

-
5CDS-intronENST00000377842ENST00000484532ACOT7chr1

6387358

-RPL22chr1

6246876

-
5CDS-intronENST00000377842ENST00000497965ACOT7chr1

6387358

-RPL22chr1

6246876

-
5CDS-intronENST00000377845ENST00000234875ACOT7chr1

6387358

-RPL22chr1

6246876

-
5CDS-intronENST00000377845ENST00000484532ACOT7chr1

6387358

-RPL22chr1

6246876

-
5CDS-intronENST00000377845ENST00000497965ACOT7chr1

6387358

-RPL22chr1

6246876

-
5CDS-intronENST00000377855ENST00000234875ACOT7chr1

6387358

-RPL22chr1

6246876

-
5CDS-intronENST00000377855ENST00000484532ACOT7chr1

6387358

-RPL22chr1

6246876

-
5CDS-intronENST00000377855ENST00000497965ACOT7chr1

6387358

-RPL22chr1

6246876

-
5CDS-intronENST00000541130ENST00000234875ACOT7chr1

6387358

-RPL22chr1

6246876

-
5CDS-intronENST00000541130ENST00000484532ACOT7chr1

6387358

-RPL22chr1

6246876

-
5CDS-intronENST00000541130ENST00000497965ACOT7chr1

6387358

-RPL22chr1

6246876

-
5CDS-intronENST00000545482ENST00000234875ACOT7chr1

6387358

-RPL22chr1

6246876

-
5CDS-intronENST00000545482ENST00000484532ACOT7chr1

6387358

-RPL22chr1

6246876

-
5CDS-intronENST00000545482ENST00000497965ACOT7chr1

6387358

-RPL22chr1

6246876

-
5CDS-intronENST00000608083ENST00000234875ACOT7chr1

6387358

-RPL22chr1

6246876

-
5CDS-intronENST00000608083ENST00000484532ACOT7chr1

6387358

-RPL22chr1

6246876

-
5CDS-intronENST00000608083ENST00000497965ACOT7chr1

6387358

-RPL22chr1

6246876

-
Frame-shiftENST00000361521ENST00000234875ACOT7chr1

6387358

-RPL22chr1

6253114

-
Frame-shiftENST00000361521ENST00000484532ACOT7chr1

6387358

-RPL22chr1

6253114

-
Frame-shiftENST00000361521ENST00000497965ACOT7chr1

6387358

-RPL22chr1

6253114

-
Frame-shiftENST00000377842ENST00000234875ACOT7chr1

6387358

-RPL22chr1

6253114

-
Frame-shiftENST00000377842ENST00000484532ACOT7chr1

6387358

-RPL22chr1

6253114

-
Frame-shiftENST00000377842ENST00000497965ACOT7chr1

6387358

-RPL22chr1

6253114

-
Frame-shiftENST00000377845ENST00000234875ACOT7chr1

6387358

-RPL22chr1

6253114

-
Frame-shiftENST00000377845ENST00000484532ACOT7chr1

6387358

-RPL22chr1

6253114

-
Frame-shiftENST00000377845ENST00000497965ACOT7chr1

6387358

-RPL22chr1

6253114

-
Frame-shiftENST00000377855ENST00000234875ACOT7chr1

6387358

-RPL22chr1

6253114

-
Frame-shiftENST00000377855ENST00000484532ACOT7chr1

6387358

-RPL22chr1

6253114

-
Frame-shiftENST00000377855ENST00000497965ACOT7chr1

6387358

-RPL22chr1

6253114

-
Frame-shiftENST00000541130ENST00000234875ACOT7chr1

6387358

-RPL22chr1

6253114

-
Frame-shiftENST00000541130ENST00000484532ACOT7chr1

6387358

-RPL22chr1

6253114

-
Frame-shiftENST00000541130ENST00000497965ACOT7chr1

6387358

-RPL22chr1

6253114

-
Frame-shiftENST00000608083ENST00000234875ACOT7chr1

6387358

-RPL22chr1

6253114

-
Frame-shiftENST00000608083ENST00000484532ACOT7chr1

6387358

-RPL22chr1

6253114

-
Frame-shiftENST00000608083ENST00000497965ACOT7chr1

6387358

-RPL22chr1

6253114

-
In-frameENST00000545482ENST00000234875ACOT7chr1

6387358

-RPL22chr1

6253114

-
In-frameENST00000545482ENST00000484532ACOT7chr1

6387358

-RPL22chr1

6253114

-
In-frameENST00000545482ENST00000497965ACOT7chr1

6387358

-RPL22chr1

6253114

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000545482ACOT7chr16387358-ENST00000484532RPL22chr16253114-825482136654172
ENST00000545482ACOT7chr16387358-ENST00000234875RPL22chr16253114-24044826841228
ENST00000545482ACOT7chr16387358-ENST00000497965RPL22chr16253114-8094826841228

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000545482ENST00000484532ACOT7chr16387358-RPL22chr16253114-0.0115301390.98846984
ENST00000545482ENST00000234875ACOT7chr16387358-RPL22chr16253114-0.0063252580.99367476
ENST00000545482ENST00000497965ACOT7chr16387358-RPL22chr16253114-0.0067973960.99320257

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Fusion Genomic Features for ACOT7-RPL22


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ACOT7-RPL22


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:6387358/chr1:6253114)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACOT7chr1:6387358chr1:6253114ENST00000361521-5950_168208371.0DomainHotDog ACOT-type 1
HgeneACOT7chr1:6387358chr1:6253114ENST00000377842-5950_168167330.0DomainHotDog ACOT-type 1
HgeneACOT7chr1:6387358chr1:6253114ENST00000377845-5950_168188351.0DomainHotDog ACOT-type 1
HgeneACOT7chr1:6387358chr1:6253114ENST00000377855-5950_168218381.0DomainHotDog ACOT-type 1
TgeneRPL22chr1:6387358chr1:6253114ENST0000023487514120_12839129.0Compositional biasNote=Asp/Glu-rich (highly acidic)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACOT7chr1:6387358chr1:6253114ENST00000361521-59224_338208371.0DomainHotDog ACOT-type 2
HgeneACOT7chr1:6387358chr1:6253114ENST00000377842-59224_338167330.0DomainHotDog ACOT-type 2
HgeneACOT7chr1:6387358chr1:6253114ENST00000377845-59224_338188351.0DomainHotDog ACOT-type 2
HgeneACOT7chr1:6387358chr1:6253114ENST00000377855-59224_338218381.0DomainHotDog ACOT-type 2


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Fusion Gene Sequence for ACOT7-RPL22


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1387_1387_1_ACOT7-RPL22_ACOT7_chr1_6387358_ENST00000545482_RPL22_chr1_6253114_ENST00000234875_length(transcript)=2404nt_BP=482nt
CATTCCGCGCCGGGCCTGCCAGACACCTGCGCCCTTCTGCAGCCGCCCGCCGCATCCGCCGCCGCAGCCCCCAGCATGTCGGGCCCAGAC
GTCGAGACGCCGTCCGCCATCCAGATCTGAGCGCTGTGTGGCCGCCCTGGCTCGTGTCGAGCGCACCGACTTCCTGTCTCCCATGTGCAT
CGGTGAGGTGGCGCATGTCAGCGCGGAGATCACCTACACCTCCAAGCACTCTGTGGAGGTGCAGGTCAACGTGATGTCCGAAAACATCCT
CACAGGTGCCAAAAAGCTGACCAATAAGGCCACCCTGTGGTATGTGCCCCTGTCGCTGAAGAATGTGGACAAGGTCCTCGAGGTGCCTCC
TGTTGTGTATTCCCGGCAGGAGCAGGAGGAGGAGGGCCGGAAGCGGTATGAAGCCCAGAAGCTGGAGCGCATGGAGACCAAGTGGAGGAA
CGGGGACATCGTCCAGCCAGTCCTCAACCCAGGAGCAGTTTTTGCAAGAAAGGATCAAAGTGAACGGAAAAGCTGGGAACCTTGGTGGAG
GGGTGGTGACCATCGAAAGGAGCAAGAGCAAGATCACCGTGACATCCGAGGTGCCTTTCTCCAAAAGGTATTTGAAATATCTCACCAAAA
AATATTTGAAGAAGAATAATCTACGTGACTGGTTGCGCGTAGTTGCTAACAGCAAAGAGAGTTACGAATTACGTTACTTCCAGATTAACC
AGGACGAAGAAGAGGAGGAAGACGAGGATTAAATTTCATTTATCTGGAAAATTTTGTATGAGTTCTTGAATAAAACTTGGGAACCAAAAT
GGTGGTTTATCCTTGTATCTCTGCAGTGTGGATTGAACAGAAAATTGGAAATCATAGTCAAAGGGCTTCCCTTGGTTCGCCACTCATTTA
TTTGTAACTTGACTTCTTTTTTTTTCTGCTTAAAAATTTCAATTCTCGTGGTAATACCAGAGTAGAAGGAGAGGGTGACTTTACCGAACT
GACAGCCATTGGGGAGGCAGATGCGGGTGTGGAGGTGTGGGCTGAAGGTAGTGACTGTTTGATTTTAAAAAGTGTGACTGTCAGTTGTAT
CTGTTGCTTTTCTCAATGATTCAGGGATACAAATGGGCTTCTCTCATTCATTAAAAGAAAACGCGACATCTTTCTAAGATTCTCTGTGGG
AAAATGACTGTCAATAAAATGCGGGTTTCTGGGCCATTCGTCTTACTTTCATTTTTTGATTACAAATTTCTCTTGACGCACACAATTATG
TCTGCTAATCCTCTTCTTCCTAGAGAGAGAAACTGTGCTCCTTCAGTGTTGCTGCCATAAAGGGGTTTGGGGAATCGATTGTAAAAGTCC
CAGGTTCTAAATTAACTAAATGTGTACAGAAATGAACGTGTAAGTAATGTTTCTACAGGTCTTTGCAACAAACTGTCACTTTCGTCTCCA
GCAGAGGGAGCTGTAGGAATAGTGCTTCCAGATGTGGTCTCCCGTGTGGGGCCCAGCAATGGGGGCCCCTGATGCCAAGAGCTCTGGAGG
TTCTTGAAAGAGGGGACACGAAGGAGGAGTGACTGGGAAGCCTCCCATGCCAAGGAGGTGGGAGGTGCCCTGGAAATAGCTGCCTCATGC
CACTTAGGCCATGACTGGATTTAATGTCAGTGGTGTGCCACAGTGCAGAGGCTAGACAACTGAAAGGGGCTACCAAGGCTGGGAAAAAAA
TGCAATTGTTGCTGTGAGTGACTTTGAAAGACTCTGGTGCCTTGTGGTGCCCTTCTGAAATTCAAACAGTAATGCAAAAGTGTCTGCATT
AGAATTTACGGTGTCTAAAATTCATGTTTTTAAAAGAGCTTGCCTACAGATGGTTTCCACACTTGAAATTGTGCCCTGCGAGTTGCATAG
CTGGAAGTTCAATGCTCAGTCCTACCTTGGCTCCCATTAAACATTTGGTGCTCTGTGGATTGAGTTGAACGTGTTGAGGCTTTGCAATTT
CACTTGTGTTAAAGGCTCTGGCATTTTTCCATTTCTATGCAAATTTCTTTGAAGCAGAATTGCTTGCATATTTCTTCTCTGCCGTCACAG
AAAGCAGAGTTTCTTTCAAACTTCACTGAGGCATCAGTTGCTCTTTGGCAATGTCCCTTAACCATGATTATTAACTAAGTTTGTGGCTTG
AGTTTACAAATTCTACTTGTTGCATTGATGTTCCCATGTAGTAAGTCATTTTTAGTTTGGTTGTGAAAAAACCCTGGGCTGAAGTTGGCA
TTTCAGTTAAAAGAAAAAAAGAAACTAGTCCCAGATTTGAAAACTTGTAATAAAATTGAAACTCACTGGTTTTCTATGTCTTTTTGAACT

>1387_1387_1_ACOT7-RPL22_ACOT7_chr1_6387358_ENST00000545482_RPL22_chr1_6253114_ENST00000234875_length(amino acids)=228AA_BP=1
MLLATTRNQSRRLFFFKYFLVRYFKYLLEKGTSDVTVILLLLLSMVTTPPPRFPAFPFTLILSCKNCSWVEDWLDDVPVPPLGLHALQLL
GFIPLPALLLLLLPGIHNRRHLEDLVHILQRQGHIPQGGLIGQLFGTCEDVFGHHVDLHLHRVLGGVGDLRADMRHLTDAHGRQEVGALD

--------------------------------------------------------------
>1387_1387_2_ACOT7-RPL22_ACOT7_chr1_6387358_ENST00000545482_RPL22_chr1_6253114_ENST00000484532_length(transcript)=825nt_BP=482nt
CATTCCGCGCCGGGCCTGCCAGACACCTGCGCCCTTCTGCAGCCGCCCGCCGCATCCGCCGCCGCAGCCCCCAGCATGTCGGGCCCAGAC
GTCGAGACGCCGTCCGCCATCCAGATCTGAGCGCTGTGTGGCCGCCCTGGCTCGTGTCGAGCGCACCGACTTCCTGTCTCCCATGTGCAT
CGGTGAGGTGGCGCATGTCAGCGCGGAGATCACCTACACCTCCAAGCACTCTGTGGAGGTGCAGGTCAACGTGATGTCCGAAAACATCCT
CACAGGTGCCAAAAAGCTGACCAATAAGGCCACCCTGTGGTATGTGCCCCTGTCGCTGAAGAATGTGGACAAGGTCCTCGAGGTGCCTCC
TGTTGTGTATTCCCGGCAGGAGCAGGAGGAGGAGGGCCGGAAGCGGTATGAAGCCCAGAAGCTGGAGCGCATGGAGACCAAGTGGAGGAA
CGGGGACATCGTCCAGCCAGTCCTCAACCCAGGAGCAGTTTTTGCAAGAAAGGATCAAAGTGAACGGAAAAGCTGGGAACCTTGGTGGAG
GGGTGGTGACCATCGAAAGGAGCAAGAGCAAGATCACCGTGACATCCGAGGTGCCTTTCTCCAAAAGGCGGCCAGCACTGGGCTGACCCG
GCTTCTCTATCTACAGCGTAGTTAAAGCGGATCTGGGAGATGGAGGGGTTCCCAACACCCCAGTCTTTGGTTCCAGAAGGCTGGACCGAC
CTCTCCTTGCCCAGGGATGAATGCAGAGGGTCTTTTGTTTGGGGTTTGCTGGCAATAAAATTGAACGGGAAGAAGGGAAACTGCTGCCGA

>1387_1387_2_ACOT7-RPL22_ACOT7_chr1_6387358_ENST00000545482_RPL22_chr1_6253114_ENST00000484532_length(amino acids)=172AA_BP=1
MARVERTDFLSPMCIGEVAHVSAEITYTSKHSVEVQVNVMSENILTGAKKLTNKATLWYVPLSLKNVDKVLEVPPVVYSRQEQEEEGRKR

--------------------------------------------------------------
>1387_1387_3_ACOT7-RPL22_ACOT7_chr1_6387358_ENST00000545482_RPL22_chr1_6253114_ENST00000497965_length(transcript)=809nt_BP=482nt
CATTCCGCGCCGGGCCTGCCAGACACCTGCGCCCTTCTGCAGCCGCCCGCCGCATCCGCCGCCGCAGCCCCCAGCATGTCGGGCCCAGAC
GTCGAGACGCCGTCCGCCATCCAGATCTGAGCGCTGTGTGGCCGCCCTGGCTCGTGTCGAGCGCACCGACTTCCTGTCTCCCATGTGCAT
CGGTGAGGTGGCGCATGTCAGCGCGGAGATCACCTACACCTCCAAGCACTCTGTGGAGGTGCAGGTCAACGTGATGTCCGAAAACATCCT
CACAGGTGCCAAAAAGCTGACCAATAAGGCCACCCTGTGGTATGTGCCCCTGTCGCTGAAGAATGTGGACAAGGTCCTCGAGGTGCCTCC
TGTTGTGTATTCCCGGCAGGAGCAGGAGGAGGAGGGCCGGAAGCGGTATGAAGCCCAGAAGCTGGAGCGCATGGAGACCAAGTGGAGGAA
CGGGGACATCGTCCAGCCAGTCCTCAACCCAGGAGCAGTTTTTGCAAGAAAGGATCAAAGTGAACGGAAAAGCTGGGAACCTTGGTGGAG
GGGTGGTGACCATCGAAAGGAGCAAGAGCAAGATCACCGTGACATCCGAGGTGCCTTTCTCCAAAAGGTATTTGAAATATCTCACCAAAA
AATATTTGAAGAAGAATAATCTACGTGACTGGTTGCGCGTAGTTGCTAACAGCAAAGAGAGTTACGAATTACGTTACTTCCAGATTAACC

>1387_1387_3_ACOT7-RPL22_ACOT7_chr1_6387358_ENST00000545482_RPL22_chr1_6253114_ENST00000497965_length(amino acids)=228AA_BP=1
MLLATTRNQSRRLFFFKYFLVRYFKYLLEKGTSDVTVILLLLLSMVTTPPPRFPAFPFTLILSCKNCSWVEDWLDDVPVPPLGLHALQLL
GFIPLPALLLLLLPGIHNRRHLEDLVHILQRQGHIPQGGLIGQLFGTCEDVFGHHVDLHLHRVLGGVGDLRADMRHLTDAHGRQEVGALD

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Fusion Gene PPI Analysis for ACOT7-RPL22


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACOT7-RPL22


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACOT7-RPL22


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource