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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:DTX2-ZP3 (FusionGDB2 ID:HG113878TG7784) |
Fusion Gene Summary for DTX2-ZP3 |
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Fusion gene information | Fusion gene name: DTX2-ZP3 | Fusion gene ID: hg113878tg7784 | Hgene | Tgene | Gene symbol | DTX2 | ZP3 | Gene ID | 113878 | 7784 |
Gene name | deltex E3 ubiquitin ligase 2 | zona pellucida glycoprotein 3 | |
Synonyms | RNF58 | OOMD3|ZP3A|ZP3B|ZPC|Zp-3 | |
Cytomap | ('DTX2')('ZP3') 7q11.23 | 7q11.23 | |
Type of gene | protein-coding | protein-coding | |
Description | probable E3 ubiquitin-protein ligase DTX2RING-type E3 ubiquitin transferase DTX2deltex 2, E3 ubiquitin ligasedeltex homolog 2deltex2hDTX2protein deltex-2ring finger protein 58zinc ion binding protein | zona pellucida sperm-binding protein 3ZP3A/ZP3Bsperm receptorzona pellucida glycoprotein 3Bzona pellucida glycoprotein ZP3zona pellucida protein C | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000307569, ENST00000324432, ENST00000413936, ENST00000430490, ENST00000446600, ENST00000446820, ENST00000472426, | ||
Fusion gene scores | * DoF score | 9 X 8 X 9=648 | 9 X 10 X 9=810 |
# samples | 15 | 14 | |
** MAII score | log2(15/648*10)=-2.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(14/810*10)=-2.53249508082702 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DTX2 [Title/Abstract] AND ZP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | DTX2(76093026)-ZP3(76054369), # samples:2 DTX2(76093026)-ZP3(76054368), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ZP3 | GO:0002922 | positive regulation of humoral immune response | 19004505 |
Tgene | ZP3 | GO:0007339 | binding of sperm to zona pellucida | 19246320|19700799 |
Tgene | ZP3 | GO:2000344 | positive regulation of acrosome reaction | 11751269|18667750|20394732 |
Tgene | ZP3 | GO:2000360 | negative regulation of binding of sperm to zona pellucida | 18667750 |
Tgene | ZP3 | GO:2000368 | positive regulation of acrosomal vesicle exocytosis | 19246320 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-GI-A2C9 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
ChimerDB4 | HNSC | TCGA-BB-A5HY-01A | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
ChimerDB4 | HNSC | TCGA-BB-A5HY | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
ChimerDB4 | HNSC | TCGA-BB-A5HY | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
ChimerDB4 | HNSC | TCGA-BB-A5HY | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
ChimerDB4 | OV | TCGA-13-0765-01A | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
ChimerDB4 | OV | TCGA-13-0765 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
ChimerDB4 | OV | TCGA-13-0765 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
Top |
Fusion Gene ORF analysis for DTX2-ZP3 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000307569 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
5UTR-3CDS | ENST00000307569 | ENST00000336517 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000307569 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000307569 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
5UTR-3CDS | ENST00000307569 | ENST00000394857 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000307569 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000307569 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
5UTR-3CDS | ENST00000307569 | ENST00000416245 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000307569 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000324432 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
5UTR-3CDS | ENST00000324432 | ENST00000336517 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000324432 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000324432 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
5UTR-3CDS | ENST00000324432 | ENST00000394857 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000324432 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000324432 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
5UTR-3CDS | ENST00000324432 | ENST00000416245 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000324432 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000413936 | ENST00000336517 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000413936 | ENST00000394857 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000413936 | ENST00000416245 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000430490 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
5UTR-3CDS | ENST00000430490 | ENST00000336517 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000430490 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000430490 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
5UTR-3CDS | ENST00000430490 | ENST00000394857 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000430490 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000430490 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
5UTR-3CDS | ENST00000430490 | ENST00000416245 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000430490 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000446600 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
5UTR-3CDS | ENST00000446600 | ENST00000336517 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000446600 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000446600 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
5UTR-3CDS | ENST00000446600 | ENST00000394857 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000446600 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000446600 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
5UTR-3CDS | ENST00000446600 | ENST00000416245 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3CDS | ENST00000446600 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3UTR | ENST00000307569 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
5UTR-3UTR | ENST00000307569 | ENST00000467555 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3UTR | ENST00000307569 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3UTR | ENST00000324432 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
5UTR-3UTR | ENST00000324432 | ENST00000467555 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3UTR | ENST00000324432 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3UTR | ENST00000413936 | ENST00000467555 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3UTR | ENST00000430490 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
5UTR-3UTR | ENST00000430490 | ENST00000467555 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3UTR | ENST00000430490 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3UTR | ENST00000446600 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
5UTR-3UTR | ENST00000446600 | ENST00000467555 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
5UTR-3UTR | ENST00000446600 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
5UTR-5UTR | ENST00000307569 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
5UTR-5UTR | ENST00000307569 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
5UTR-5UTR | ENST00000307569 | ENST00000336517 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
5UTR-5UTR | ENST00000307569 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
5UTR-5UTR | ENST00000307569 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
5UTR-5UTR | ENST00000307569 | ENST00000394857 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
5UTR-5UTR | ENST00000324432 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
5UTR-5UTR | ENST00000324432 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
5UTR-5UTR | ENST00000324432 | ENST00000336517 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
5UTR-5UTR | ENST00000324432 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
5UTR-5UTR | ENST00000324432 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
5UTR-5UTR | ENST00000324432 | ENST00000394857 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
5UTR-5UTR | ENST00000413936 | ENST00000336517 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
5UTR-5UTR | ENST00000413936 | ENST00000394857 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
5UTR-5UTR | ENST00000430490 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
5UTR-5UTR | ENST00000430490 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
5UTR-5UTR | ENST00000430490 | ENST00000336517 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
5UTR-5UTR | ENST00000430490 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
5UTR-5UTR | ENST00000430490 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
5UTR-5UTR | ENST00000430490 | ENST00000394857 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
5UTR-5UTR | ENST00000446600 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
5UTR-5UTR | ENST00000446600 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
5UTR-5UTR | ENST00000446600 | ENST00000336517 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
5UTR-5UTR | ENST00000446600 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
5UTR-5UTR | ENST00000446600 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
5UTR-5UTR | ENST00000446600 | ENST00000394857 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
5UTR-intron | ENST00000307569 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
5UTR-intron | ENST00000307569 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
5UTR-intron | ENST00000307569 | ENST00000416245 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
5UTR-intron | ENST00000307569 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
5UTR-intron | ENST00000307569 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
5UTR-intron | ENST00000307569 | ENST00000467555 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
5UTR-intron | ENST00000324432 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
5UTR-intron | ENST00000324432 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
5UTR-intron | ENST00000324432 | ENST00000416245 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
5UTR-intron | ENST00000324432 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
5UTR-intron | ENST00000324432 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
5UTR-intron | ENST00000324432 | ENST00000467555 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
5UTR-intron | ENST00000413936 | ENST00000416245 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
5UTR-intron | ENST00000413936 | ENST00000467555 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
5UTR-intron | ENST00000430490 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
5UTR-intron | ENST00000430490 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
5UTR-intron | ENST00000430490 | ENST00000416245 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
5UTR-intron | ENST00000430490 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
5UTR-intron | ENST00000430490 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
5UTR-intron | ENST00000430490 | ENST00000467555 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
5UTR-intron | ENST00000446600 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
5UTR-intron | ENST00000446600 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
5UTR-intron | ENST00000446600 | ENST00000416245 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
5UTR-intron | ENST00000446600 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
5UTR-intron | ENST00000446600 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
5UTR-intron | ENST00000446600 | ENST00000467555 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
intron-3CDS | ENST00000413936 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
intron-3CDS | ENST00000413936 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
intron-3CDS | ENST00000413936 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
intron-3CDS | ENST00000413936 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
intron-3CDS | ENST00000413936 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
intron-3CDS | ENST00000413936 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
intron-3CDS | ENST00000446820 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
intron-3CDS | ENST00000446820 | ENST00000336517 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
intron-3CDS | ENST00000446820 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
intron-3CDS | ENST00000446820 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
intron-3CDS | ENST00000446820 | ENST00000394857 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
intron-3CDS | ENST00000446820 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
intron-3CDS | ENST00000446820 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
intron-3CDS | ENST00000446820 | ENST00000416245 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
intron-3CDS | ENST00000446820 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
intron-3CDS | ENST00000472426 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
intron-3CDS | ENST00000472426 | ENST00000336517 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
intron-3CDS | ENST00000472426 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
intron-3CDS | ENST00000472426 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
intron-3CDS | ENST00000472426 | ENST00000394857 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
intron-3CDS | ENST00000472426 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
intron-3CDS | ENST00000472426 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
intron-3CDS | ENST00000472426 | ENST00000416245 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
intron-3CDS | ENST00000472426 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
intron-3UTR | ENST00000413936 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
intron-3UTR | ENST00000413936 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
intron-3UTR | ENST00000446820 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
intron-3UTR | ENST00000446820 | ENST00000467555 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
intron-3UTR | ENST00000446820 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
intron-3UTR | ENST00000472426 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069567 | + |
intron-3UTR | ENST00000472426 | ENST00000467555 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + |
intron-3UTR | ENST00000472426 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + |
intron-5UTR | ENST00000413936 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
intron-5UTR | ENST00000413936 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
intron-5UTR | ENST00000413936 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
intron-5UTR | ENST00000413936 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
intron-5UTR | ENST00000446820 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
intron-5UTR | ENST00000446820 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
intron-5UTR | ENST00000446820 | ENST00000336517 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
intron-5UTR | ENST00000446820 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
intron-5UTR | ENST00000446820 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
intron-5UTR | ENST00000446820 | ENST00000394857 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
intron-5UTR | ENST00000472426 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
intron-5UTR | ENST00000472426 | ENST00000336517 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
intron-5UTR | ENST00000472426 | ENST00000336517 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
intron-5UTR | ENST00000472426 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
intron-5UTR | ENST00000472426 | ENST00000394857 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
intron-5UTR | ENST00000472426 | ENST00000394857 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
intron-intron | ENST00000413936 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
intron-intron | ENST00000413936 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
intron-intron | ENST00000413936 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
intron-intron | ENST00000413936 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
intron-intron | ENST00000446820 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
intron-intron | ENST00000446820 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
intron-intron | ENST00000446820 | ENST00000416245 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
intron-intron | ENST00000446820 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
intron-intron | ENST00000446820 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
intron-intron | ENST00000446820 | ENST00000467555 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
intron-intron | ENST00000472426 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
intron-intron | ENST00000472426 | ENST00000416245 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
intron-intron | ENST00000472426 | ENST00000416245 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
intron-intron | ENST00000472426 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + |
intron-intron | ENST00000472426 | ENST00000467555 | DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054369 | + |
intron-intron | ENST00000472426 | ENST00000467555 | DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for DTX2-ZP3 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + | 0.000243 | 0.999757 |
DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + | 0.000243 | 0.999757 |
DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + | 1.09E-05 | 0.99998915 |
DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + | 9.25E-07 | 0.99999905 |
DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + | 9.25E-07 | 0.99999905 |
DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + | 9.25E-07 | 0.99999905 |
DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + | 6.55E-08 | 0.9999999 |
DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + | 0.000243 | 0.999757 |
DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76069566 | + | 0.000243 | 0.999757 |
DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76069566 | + | 1.09E-05 | 0.99998915 |
DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + | 9.25E-07 | 0.99999905 |
DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + | 9.25E-07 | 0.99999905 |
DTX2 | chr7 | 76093026 | + | ZP3 | chr7 | 76054368 | + | 9.25E-07 | 0.99999905 |
DTX2 | chr7 | 76091153 | + | ZP3 | chr7 | 76054368 | + | 6.55E-08 | 0.9999999 |
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Fusion Protein Features for DTX2-ZP3 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:76093026/:76054369) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for DTX2-ZP3 |
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Fusion Gene PPI Analysis for DTX2-ZP3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DTX2-ZP3 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DTX2-ZP3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DTX2 | C0006118 | Brain Neoplasms | 1 | CTD_human |
Hgene | DTX2 | C0153633 | Malignant neoplasm of brain | 1 | CTD_human |
Hgene | DTX2 | C0496899 | Benign neoplasm of brain, unspecified | 1 | CTD_human |
Hgene | DTX2 | C0750974 | Brain Tumor, Primary | 1 | CTD_human |
Hgene | DTX2 | C0750977 | Recurrent Brain Neoplasm | 1 | CTD_human |
Hgene | DTX2 | C0750979 | Primary malignant neoplasm of brain | 1 | CTD_human |
Hgene | DTX2 | C1527390 | Neoplasms, Intracranial | 1 | CTD_human |
Tgene | C4540205 | OOCYTE MATURATION DEFECT 3 | 2 | ORPHANET;UNIPROT | |
Tgene | C4014291 | OOCYTE MATURATION DEFECT 1 | 1 | ORPHANET |