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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCDC85A-EYA2 (FusionGDB2 ID:HG114800TG2139)

Fusion Gene Summary for CCDC85A-EYA2

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC85A-EYA2
Fusion gene ID: hg114800tg2139
HgeneTgene
Gene symbol

CCDC85A

EYA2

Gene ID

114800

2139

Gene namecoiled-coil domain containing 85AEYA transcriptional coactivator and phosphatase 2
Synonyms-EAB1
Cytomap('CCDC85A')('EYA2')

2p16.1

20q13.12

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 85Aeyes absent homolog 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000407595, 
Fusion gene scores* DoF score4 X 3 X 3=3615 X 15 X 10=2250
# samples 430
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(30/2250*10)=-2.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCDC85A [Title/Abstract] AND EYA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCDC85A(56570090)-EYA2(45771698), # samples:2
Anticipated loss of major functional domain due to fusion event.CCDC85A-EYA2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CCDC85A-EYA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEYA2

GO:0016576

histone dephosphorylation

19351884


check buttonFusion gene breakpoints across CCDC85A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across EYA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-09-2051-01ACCDC85Achr2

56570090

+EYA2chr20

45771698

+
ChimerDB4OVTCGA-09-2051CCDC85Achr2

56570090

+EYA2chr20

45771697

+


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Fusion Gene ORF analysis for CCDC85A-EYA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000407595ENST00000317304CCDC85Achr2

56570090

+EYA2chr20

45771698

+
5CDS-intronENST00000407595ENST00000317304CCDC85Achr2

56570090

+EYA2chr20

45771697

+
5CDS-intronENST00000407595ENST00000497428CCDC85Achr2

56570090

+EYA2chr20

45771698

+
5CDS-intronENST00000407595ENST00000497428CCDC85Achr2

56570090

+EYA2chr20

45771697

+
In-frameENST00000407595ENST00000327619CCDC85Achr2

56570090

+EYA2chr20

45771698

+
In-frameENST00000407595ENST00000327619CCDC85Achr2

56570090

+EYA2chr20

45771697

+
In-frameENST00000407595ENST00000357410CCDC85Achr2

56570090

+EYA2chr20

45771698

+
In-frameENST00000407595ENST00000357410CCDC85Achr2

56570090

+EYA2chr20

45771697

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000407595CCDC85Achr256570090+ENST00000357410EYA2chr2045771698+302218195022310602
ENST00000407595CCDC85Achr256570090+ENST00000327619EYA2chr2045771698+325918195022547681
ENST00000407595CCDC85Achr256570090+ENST00000357410EYA2chr2045771697+302218195022310602
ENST00000407595CCDC85Achr256570090+ENST00000327619EYA2chr2045771697+325918195022547681

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000407595ENST00000357410CCDC85Achr256570090+EYA2chr2045771698+0.0218816770.97811836
ENST00000407595ENST00000327619CCDC85Achr256570090+EYA2chr2045771698+0.0226377420.9773622
ENST00000407595ENST00000357410CCDC85Achr256570090+EYA2chr2045771697+0.0218816770.97811836
ENST00000407595ENST00000327619CCDC85Achr256570090+EYA2chr2045771697+0.0226377420.9773622

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Fusion Genomic Features for CCDC85A-EYA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CCDC85Achr256570090+EYA2chr2045771697+4.07E-050.99995923
CCDC85Achr256570090+EYA2chr2045771697+4.07E-050.99995923
CCDC85Achr256570090+EYA2chr2045771697+4.07E-050.99995923
CCDC85Achr256570090+EYA2chr2045771697+4.07E-050.99995923

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CCDC85A-EYA2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:56570090/chr20:45771698)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCDC85Achr2:56570090chr20:45771697ENST00000407595+36137_169439554.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC85Achr2:56570090chr20:45771697ENST00000407595+3643_109439554.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC85Achr2:56570090chr20:45771698ENST00000407595+36137_169439554.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC85Achr2:56570090chr20:45771698ENST00000407595+3643_109439554.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC85Achr2:56570090chr20:45771697ENST00000407595+36224_374439554.0Compositional biasNote=His-rich
HgeneCCDC85Achr2:56570090chr20:45771697ENST00000407595+364_31439554.0Compositional biasNote=Ala-rich
HgeneCCDC85Achr2:56570090chr20:45771698ENST00000407595+36224_374439554.0Compositional biasNote=His-rich
HgeneCCDC85Achr2:56570090chr20:45771698ENST00000407595+364_31439554.0Compositional biasNote=Ala-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCDC85Achr2:56570090chr20:45771697ENST00000407595+36412_443439554.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC85Achr2:56570090chr20:45771698ENST00000407595+36412_443439554.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for CCDC85A-EYA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13946_13946_1_CCDC85A-EYA2_CCDC85A_chr2_56570090_ENST00000407595_EYA2_chr20_45771697_ENST00000327619_length(transcript)=3259nt_BP=1819nt
GCGCCGCGGTGCCCGGCGCGCCCTCCAAGCTAGGAGAGGGGAGAAGCCGGGGGCTGCAGCTGGGCAAGGGGGAGGAAAGTGCGTGTGCGT
GCACGCCTGTGTGCAGGGCAGAGAGTGCGGGGGGCGACAGTCTCGGCTTAGGGCGGAGGAGAGGGCAGGGGAACGGCGGTGCAGCTCCCC
CGCTGTCCCCGAGGATTTCCCGCGGCAGCCCCGGGCTCCCCAGTGCCCCTCACCATGGACTTGCGCGGAGTTGGGACGGGCCTCGGCAGC
AGCAAGCGGCTGGCTGCCGGGCCCTGGGGGAGCGCGGGCGCGCGCGCGGGGATGGCGAGGTAGGATGGCCACCCAGCGCGACCCCCGCCG
CCCCAACCCAGCGGCCCCTGGGCGGTGCCGCTGACTCGCCGGAGCGCACAGGGGTGTGGGCGGAGGCGGCCTCGCCGCGCCCGCGCCTTC
GGGAGTCGCCTCGCCTCTTCCACCCACTTGCACCTGCCACCCCGCGGATACCATGTCGAAGGCGGCCGGAGGCGCGGCGGCGGCTGCGGC
GGCGGCGGAAAGTTGTTCCCCAGCCCCGGCCGGCTCGTCCGCGGCCCCGCCCGCGCCGGTGGAGGACCTGTCCAAAGTGTCGGACGAGGA
GCTGCTGCAGTGGAGCAAGGAGGAGCTGATCCGCAGCCTGCGGCGCGCCGAGGCGGAGAAGGTGAGCGCGATGCTGGACCACAGCAACCT
CATCCGCGAGGTGAACCGCCGCCTGCAGCTGCACCTCGGCGAGATCCGCGGCCTCAAGGATATCAACCAGAAACTCCAGGAAGACAACCA
GGAACTGAGGGACCTCTGCTGTTTCCTGGATGATGACCGGCAGAAAGGCAAGAGGGTGTCTCGGGAGTGGCAGAGACTGGGTCGCTACAC
TGCCGGGGTGATGCACAAGGAAGTGGCCTTATACCTGCAGAAGCTGAAAGACCTGGAGGTGAAGCAGGAGGAAGTGGTGAAGGAGAACAT
GGAGCTCAAGGAGCTCTGTGTGCTACTAGATGAGGAGAAGGGTGCAGGCTGCGCAGGCAGCCGCTGCTCCATCGACAGCCAGGCCAGCCT
GTGCCAACTCACAGCCTCCACCGCACCCTACGTGCGGGATGTGGGTGACGGCAGCAGCACCTCCAGCACTGGCAGCACTGACAGCCCGGA
CCACCACAAGCACCACGCGAGCAGTGGCAGCCCGGAGCACCTGCAGAAGCCCCGGAGCGAGGGCAGCCCGGAGCACTCCAAGCACAGGAG
CGCCAGCCCCGAGCATCCACAGAAACCCAGAGCCTGTGGAACCCCAGATCGCCCCAAAGCACTCAAAGGACCTAGCCCGGAGCACCACAA
ACCCTTGTGCAAGGGCAGCCCCGAACAGCAAAGGCACCCGCATCCAGGGAGCAGCCCCGAAACGCTGCCCAAGCACGTGCTGAGTGGGAG
CCCGGAACACTTCCAGAAGCACCGGTCAGGGAGCAGCCCTGAACACGCCAGGCACAGTGGAGGGAGCCCGGAGCATCTTCAGAAACACGC
TCTTGGGGGGAGCCTAGAGCATCTCCCCAGAGCCAGGGGCACCAGCCCGGAGCACCTCAAACAACATTATGGAGGGAGCCCTGATCACAA
ACACGGAGGAGGCAGTGGAGGAAGTGGAGGCAGCGGCGGAGGCAGCAGGGAGGGCACCCTCAGACGGCAGGCACAGGAGGACGGGTCACC
CCATCACCGGAATGTCTACAGTGGCATGAACGAATCAACCTTGTCCTATGTTAGGCAGCTGGAGGCAAGAGTAAGACAGCTGGAGGAAGA
AAATCGCATGCTGCCCCAGGACACCACGACGTCCGTGCGCATTGGCCTTATGATGGAAGAGATGATCTTCAACCTTGCAGATACACATCT
GTTCTTCAATGACCTGGAGGATTGTGACCAGATCCACGTTGATGACGTCTCATCAGATGACAATGGCCAAGATTTAAGCACATACAACTT
CTCCGCTGACGGCTTCCACAGTTCGGCCCCAGGAGCCAACCTGTGCCTGGGCTCTGGCGTGCACGGCGGCGTGGACTGGATGAGGAAGCT
GGCCTTCCGCTACCGGCGGGTGAAGGAGATGTACAATACCTACAAGAACAACGTTGGTGGGTTGATAGGCACTCCCAAAAGGGAGACCTG
GCTACAGCTCCGAGCTGAGCTGGAAGCTCTCACAGACCTCTGGCTGACCCACTCCCTGAAGGCACTAAACCTCATCAACTCCCGGCCCAA
CTGTGTCAATGTGCTGGTCACCACCACTCAACTAATTCCTGCCCTGGCCAAAGTCCTGCTATATGGCCTGGGGTCTGTGTTTCCTATTGA
GAACATCTACAGTGCAACCAAGACAGGGAAGGAGAGCTGCTTCGAGAGGATAATGCAGAGATTCGGCAGAAAAGCTGTCTACGTGGTGAT
CGGTGATGGTGTGGAAGAGGAGCAAGGAGCGAAAAAGCACAACATGCCTTTCTGGCGGATATCCTGCCACGCAGACCTGGAGGCACTGAG
GCACGCCCTGGAGCTGGAGTATTTATAGCAGGATCAGCAGCATCTCCACCTGCCATCTCACCCTCAGACCCCCTCGCCTTCCCCACCTCC
CCACCGAGAACTCCAGAGACCCAGATGTTGGACACCAGGAAGGGGCCCCACAGCCGAGACGACGTGTCCAGTGACCATCTCAGAAGCCGT
CCATCAGTCCAAATGGGGGTTCTGAGAAGGAAAGTACCCAACATTGGCTTCGGAGTATTTGACTTTGGGGAAAAGGGCTGGCTCGGAGTC
TAGACTCTTCTGTAAGACTCACAGAACAAAAGCAAGGAATTGCTGATTTGGGGGGTGCCTGGTGATGAGGAGGGGATGGGTTTGTCTTGT
CTTCTTTTTAATTTATGGACTAGTCTCATTACTCCGGAATTATGCTCTTGTACCTGTGTGGCTGGGTTTCTTAGTCGTTGGTTTGGTTTG
GTTTTTTGAACTGGTATGTGGGGTGGTTCACAGTTCTAATGTAAGCACTCTATTCTCCAAGTTGTGCTTTGTGGGGACAATCATTCTTTG
AACATTAGAGAGGAAGGCAGTTCAAGCTGTTGAAAAGACTATTGCTTATTTTTGTTTTTAAAGACCTACTTGACGTCATGTGGACAGTGC
ACGTGCCTTACGCTACATCTTGTTTTCTAGGAAGAGGGGGATGCTGGGAAGGAATGGGTGCTTTGTGATGGATAAAAGGCATTAAATAAA
ACCACGTTTACATTTTGAA

>13946_13946_1_CCDC85A-EYA2_CCDC85A_chr2_56570090_ENST00000407595_EYA2_chr20_45771697_ENST00000327619_length(amino acids)=681AA_BP=438
MSKAAGGAAAAAAAAESCSPAPAGSSAAPPAPVEDLSKVSDEELLQWSKEELIRSLRRAEAEKVSAMLDHSNLIREVNRRLQLHLGEIRG
LKDINQKLQEDNQELRDLCCFLDDDRQKGKRVSREWQRLGRYTAGVMHKEVALYLQKLKDLEVKQEEVVKENMELKELCVLLDEEKGAGC
AGSRCSIDSQASLCQLTASTAPYVRDVGDGSSTSSTGSTDSPDHHKHHASSGSPEHLQKPRSEGSPEHSKHRSASPEHPQKPRACGTPDR
PKALKGPSPEHHKPLCKGSPEQQRHPHPGSSPETLPKHVLSGSPEHFQKHRSGSSPEHARHSGGSPEHLQKHALGGSLEHLPRARGTSPE
HLKQHYGGSPDHKHGGGSGGSGGSGGGSREGTLRRQAQEDGSPHHRNVYSGMNESTLSYVRQLEARVRQLEEENRMLPQDTTTSVRIGLM
MEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNN
VGGLIGTPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERI
MQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL

--------------------------------------------------------------
>13946_13946_2_CCDC85A-EYA2_CCDC85A_chr2_56570090_ENST00000407595_EYA2_chr20_45771697_ENST00000357410_length(transcript)=3022nt_BP=1819nt
GCGCCGCGGTGCCCGGCGCGCCCTCCAAGCTAGGAGAGGGGAGAAGCCGGGGGCTGCAGCTGGGCAAGGGGGAGGAAAGTGCGTGTGCGT
GCACGCCTGTGTGCAGGGCAGAGAGTGCGGGGGGCGACAGTCTCGGCTTAGGGCGGAGGAGAGGGCAGGGGAACGGCGGTGCAGCTCCCC
CGCTGTCCCCGAGGATTTCCCGCGGCAGCCCCGGGCTCCCCAGTGCCCCTCACCATGGACTTGCGCGGAGTTGGGACGGGCCTCGGCAGC
AGCAAGCGGCTGGCTGCCGGGCCCTGGGGGAGCGCGGGCGCGCGCGCGGGGATGGCGAGGTAGGATGGCCACCCAGCGCGACCCCCGCCG
CCCCAACCCAGCGGCCCCTGGGCGGTGCCGCTGACTCGCCGGAGCGCACAGGGGTGTGGGCGGAGGCGGCCTCGCCGCGCCCGCGCCTTC
GGGAGTCGCCTCGCCTCTTCCACCCACTTGCACCTGCCACCCCGCGGATACCATGTCGAAGGCGGCCGGAGGCGCGGCGGCGGCTGCGGC
GGCGGCGGAAAGTTGTTCCCCAGCCCCGGCCGGCTCGTCCGCGGCCCCGCCCGCGCCGGTGGAGGACCTGTCCAAAGTGTCGGACGAGGA
GCTGCTGCAGTGGAGCAAGGAGGAGCTGATCCGCAGCCTGCGGCGCGCCGAGGCGGAGAAGGTGAGCGCGATGCTGGACCACAGCAACCT
CATCCGCGAGGTGAACCGCCGCCTGCAGCTGCACCTCGGCGAGATCCGCGGCCTCAAGGATATCAACCAGAAACTCCAGGAAGACAACCA
GGAACTGAGGGACCTCTGCTGTTTCCTGGATGATGACCGGCAGAAAGGCAAGAGGGTGTCTCGGGAGTGGCAGAGACTGGGTCGCTACAC
TGCCGGGGTGATGCACAAGGAAGTGGCCTTATACCTGCAGAAGCTGAAAGACCTGGAGGTGAAGCAGGAGGAAGTGGTGAAGGAGAACAT
GGAGCTCAAGGAGCTCTGTGTGCTACTAGATGAGGAGAAGGGTGCAGGCTGCGCAGGCAGCCGCTGCTCCATCGACAGCCAGGCCAGCCT
GTGCCAACTCACAGCCTCCACCGCACCCTACGTGCGGGATGTGGGTGACGGCAGCAGCACCTCCAGCACTGGCAGCACTGACAGCCCGGA
CCACCACAAGCACCACGCGAGCAGTGGCAGCCCGGAGCACCTGCAGAAGCCCCGGAGCGAGGGCAGCCCGGAGCACTCCAAGCACAGGAG
CGCCAGCCCCGAGCATCCACAGAAACCCAGAGCCTGTGGAACCCCAGATCGCCCCAAAGCACTCAAAGGACCTAGCCCGGAGCACCACAA
ACCCTTGTGCAAGGGCAGCCCCGAACAGCAAAGGCACCCGCATCCAGGGAGCAGCCCCGAAACGCTGCCCAAGCACGTGCTGAGTGGGAG
CCCGGAACACTTCCAGAAGCACCGGTCAGGGAGCAGCCCTGAACACGCCAGGCACAGTGGAGGGAGCCCGGAGCATCTTCAGAAACACGC
TCTTGGGGGGAGCCTAGAGCATCTCCCCAGAGCCAGGGGCACCAGCCCGGAGCACCTCAAACAACATTATGGAGGGAGCCCTGATCACAA
ACACGGAGGAGGCAGTGGAGGAAGTGGAGGCAGCGGCGGAGGCAGCAGGGAGGGCACCCTCAGACGGCAGGCACAGGAGGACGGGTCACC
CCATCACCGGAATGTCTACAGTGGCATGAACGAATCAACCTTGTCCTATGTTAGGCAGCTGGAGGCAAGAGTAAGACAGCTGGAGGAAGA
AAATCGCATGCTGCCCCAGGACACCACGACGTCCGTGCGCATTGGCCTTATGATGGAAGAGATGATCTTCAACCTTGCAGATACACATCT
GTTCTTCAATGACCTGGAGGATTGTGACCAGATCCACGTTGATGACGTCTCATCAGATGACAATGGCCAAGATTTAAGCACATACAACTT
CTCCGCTGACGGCTTCCACAGTTCGGCCCCAGGAGCCAACCTGTGCCTGGGCTCTGGCGTGCACGGCGGCGTGGACTGGATGAGGAAGCT
GGCCTTCCGCTACCGGCGGGTGAAGGAGATGTACAATACCTACAAGAACAACGTTGGTGGGAAGGAGAGCTGCTTCGAGAGGATAATGCA
GAGATTCGGCAGAAAAGCTGTCTACGTGGTGATCGGTGATGGTGTGGAAGAGGAGCAAGGAGCGAAAAAGCACAACATGCCTTTCTGGCG
GATATCCTGCCACGCAGACCTGGAGGCACTGAGGCACGCCCTGGAGCTGGAGTATTTATAGCAGGATCAGCAGCATCTCCACCTGCCATC
TCACCCTCAGACCCCCTCGCCTTCCCCACCTCCCCACCGAGAACTCCAGAGACCCAGATGTTGGACACCAGGAAGGGGCCCCACAGCCGA
GACGACGTGTCCAGTGACCATCTCAGAAGCCGTCCATCAGTCCAAATGGGGGTTCTGAGAAGGAAAGTACCCAACATTGGCTTCGGAGTA
TTTGACTTTGGGGAAAAGGGCTGGCTCGGAGTCTAGACTCTTCTGTAAGACTCACAGAACAAAAGCAAGGAATTGCTGATTTGGGGGGTG
CCTGGTGATGAGGAGGGGATGGGTTTGTCTTGTCTTCTTTTTAATTTATGGACTAGTCTCATTACTCCGGAATTATGCTCTTGTACCTGT
GTGGCTGGGTTTCTTAGTCGTTGGTTTGGTTTGGTTTTTTGAACTGGTATGTGGGGTGGTTCACAGTTCTAATGTAAGCACTCTATTCTC
CAAGTTGTGCTTTGTGGGGACAATCATTCTTTGAACATTAGAGAGGAAGGCAGTTCAAGCTGTTGAAAAGACTATTGCTTATTTTTGTTT
TTAAAGACCTACTTGACGTCATGTGGACAGTGCACGTGCCTTACGCTACATCTTGTTTTCTAGGAAGAGGGGGATGCTGGGAAGGAATGG
GTGCTTTGTGATGGATAAAAGGCATTAAATAAAACCACGTTTACATTTTGAA

>13946_13946_2_CCDC85A-EYA2_CCDC85A_chr2_56570090_ENST00000407595_EYA2_chr20_45771697_ENST00000357410_length(amino acids)=602AA_BP=438
MSKAAGGAAAAAAAAESCSPAPAGSSAAPPAPVEDLSKVSDEELLQWSKEELIRSLRRAEAEKVSAMLDHSNLIREVNRRLQLHLGEIRG
LKDINQKLQEDNQELRDLCCFLDDDRQKGKRVSREWQRLGRYTAGVMHKEVALYLQKLKDLEVKQEEVVKENMELKELCVLLDEEKGAGC
AGSRCSIDSQASLCQLTASTAPYVRDVGDGSSTSSTGSTDSPDHHKHHASSGSPEHLQKPRSEGSPEHSKHRSASPEHPQKPRACGTPDR
PKALKGPSPEHHKPLCKGSPEQQRHPHPGSSPETLPKHVLSGSPEHFQKHRSGSSPEHARHSGGSPEHLQKHALGGSLEHLPRARGTSPE
HLKQHYGGSPDHKHGGGSGGSGGSGGGSREGTLRRQAQEDGSPHHRNVYSGMNESTLSYVRQLEARVRQLEEENRMLPQDTTTSVRIGLM
MEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNN
VGGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL

--------------------------------------------------------------
>13946_13946_3_CCDC85A-EYA2_CCDC85A_chr2_56570090_ENST00000407595_EYA2_chr20_45771698_ENST00000327619_length(transcript)=3259nt_BP=1819nt
GCGCCGCGGTGCCCGGCGCGCCCTCCAAGCTAGGAGAGGGGAGAAGCCGGGGGCTGCAGCTGGGCAAGGGGGAGGAAAGTGCGTGTGCGT
GCACGCCTGTGTGCAGGGCAGAGAGTGCGGGGGGCGACAGTCTCGGCTTAGGGCGGAGGAGAGGGCAGGGGAACGGCGGTGCAGCTCCCC
CGCTGTCCCCGAGGATTTCCCGCGGCAGCCCCGGGCTCCCCAGTGCCCCTCACCATGGACTTGCGCGGAGTTGGGACGGGCCTCGGCAGC
AGCAAGCGGCTGGCTGCCGGGCCCTGGGGGAGCGCGGGCGCGCGCGCGGGGATGGCGAGGTAGGATGGCCACCCAGCGCGACCCCCGCCG
CCCCAACCCAGCGGCCCCTGGGCGGTGCCGCTGACTCGCCGGAGCGCACAGGGGTGTGGGCGGAGGCGGCCTCGCCGCGCCCGCGCCTTC
GGGAGTCGCCTCGCCTCTTCCACCCACTTGCACCTGCCACCCCGCGGATACCATGTCGAAGGCGGCCGGAGGCGCGGCGGCGGCTGCGGC
GGCGGCGGAAAGTTGTTCCCCAGCCCCGGCCGGCTCGTCCGCGGCCCCGCCCGCGCCGGTGGAGGACCTGTCCAAAGTGTCGGACGAGGA
GCTGCTGCAGTGGAGCAAGGAGGAGCTGATCCGCAGCCTGCGGCGCGCCGAGGCGGAGAAGGTGAGCGCGATGCTGGACCACAGCAACCT
CATCCGCGAGGTGAACCGCCGCCTGCAGCTGCACCTCGGCGAGATCCGCGGCCTCAAGGATATCAACCAGAAACTCCAGGAAGACAACCA
GGAACTGAGGGACCTCTGCTGTTTCCTGGATGATGACCGGCAGAAAGGCAAGAGGGTGTCTCGGGAGTGGCAGAGACTGGGTCGCTACAC
TGCCGGGGTGATGCACAAGGAAGTGGCCTTATACCTGCAGAAGCTGAAAGACCTGGAGGTGAAGCAGGAGGAAGTGGTGAAGGAGAACAT
GGAGCTCAAGGAGCTCTGTGTGCTACTAGATGAGGAGAAGGGTGCAGGCTGCGCAGGCAGCCGCTGCTCCATCGACAGCCAGGCCAGCCT
GTGCCAACTCACAGCCTCCACCGCACCCTACGTGCGGGATGTGGGTGACGGCAGCAGCACCTCCAGCACTGGCAGCACTGACAGCCCGGA
CCACCACAAGCACCACGCGAGCAGTGGCAGCCCGGAGCACCTGCAGAAGCCCCGGAGCGAGGGCAGCCCGGAGCACTCCAAGCACAGGAG
CGCCAGCCCCGAGCATCCACAGAAACCCAGAGCCTGTGGAACCCCAGATCGCCCCAAAGCACTCAAAGGACCTAGCCCGGAGCACCACAA
ACCCTTGTGCAAGGGCAGCCCCGAACAGCAAAGGCACCCGCATCCAGGGAGCAGCCCCGAAACGCTGCCCAAGCACGTGCTGAGTGGGAG
CCCGGAACACTTCCAGAAGCACCGGTCAGGGAGCAGCCCTGAACACGCCAGGCACAGTGGAGGGAGCCCGGAGCATCTTCAGAAACACGC
TCTTGGGGGGAGCCTAGAGCATCTCCCCAGAGCCAGGGGCACCAGCCCGGAGCACCTCAAACAACATTATGGAGGGAGCCCTGATCACAA
ACACGGAGGAGGCAGTGGAGGAAGTGGAGGCAGCGGCGGAGGCAGCAGGGAGGGCACCCTCAGACGGCAGGCACAGGAGGACGGGTCACC
CCATCACCGGAATGTCTACAGTGGCATGAACGAATCAACCTTGTCCTATGTTAGGCAGCTGGAGGCAAGAGTAAGACAGCTGGAGGAAGA
AAATCGCATGCTGCCCCAGGACACCACGACGTCCGTGCGCATTGGCCTTATGATGGAAGAGATGATCTTCAACCTTGCAGATACACATCT
GTTCTTCAATGACCTGGAGGATTGTGACCAGATCCACGTTGATGACGTCTCATCAGATGACAATGGCCAAGATTTAAGCACATACAACTT
CTCCGCTGACGGCTTCCACAGTTCGGCCCCAGGAGCCAACCTGTGCCTGGGCTCTGGCGTGCACGGCGGCGTGGACTGGATGAGGAAGCT
GGCCTTCCGCTACCGGCGGGTGAAGGAGATGTACAATACCTACAAGAACAACGTTGGTGGGTTGATAGGCACTCCCAAAAGGGAGACCTG
GCTACAGCTCCGAGCTGAGCTGGAAGCTCTCACAGACCTCTGGCTGACCCACTCCCTGAAGGCACTAAACCTCATCAACTCCCGGCCCAA
CTGTGTCAATGTGCTGGTCACCACCACTCAACTAATTCCTGCCCTGGCCAAAGTCCTGCTATATGGCCTGGGGTCTGTGTTTCCTATTGA
GAACATCTACAGTGCAACCAAGACAGGGAAGGAGAGCTGCTTCGAGAGGATAATGCAGAGATTCGGCAGAAAAGCTGTCTACGTGGTGAT
CGGTGATGGTGTGGAAGAGGAGCAAGGAGCGAAAAAGCACAACATGCCTTTCTGGCGGATATCCTGCCACGCAGACCTGGAGGCACTGAG
GCACGCCCTGGAGCTGGAGTATTTATAGCAGGATCAGCAGCATCTCCACCTGCCATCTCACCCTCAGACCCCCTCGCCTTCCCCACCTCC
CCACCGAGAACTCCAGAGACCCAGATGTTGGACACCAGGAAGGGGCCCCACAGCCGAGACGACGTGTCCAGTGACCATCTCAGAAGCCGT
CCATCAGTCCAAATGGGGGTTCTGAGAAGGAAAGTACCCAACATTGGCTTCGGAGTATTTGACTTTGGGGAAAAGGGCTGGCTCGGAGTC
TAGACTCTTCTGTAAGACTCACAGAACAAAAGCAAGGAATTGCTGATTTGGGGGGTGCCTGGTGATGAGGAGGGGATGGGTTTGTCTTGT
CTTCTTTTTAATTTATGGACTAGTCTCATTACTCCGGAATTATGCTCTTGTACCTGTGTGGCTGGGTTTCTTAGTCGTTGGTTTGGTTTG
GTTTTTTGAACTGGTATGTGGGGTGGTTCACAGTTCTAATGTAAGCACTCTATTCTCCAAGTTGTGCTTTGTGGGGACAATCATTCTTTG
AACATTAGAGAGGAAGGCAGTTCAAGCTGTTGAAAAGACTATTGCTTATTTTTGTTTTTAAAGACCTACTTGACGTCATGTGGACAGTGC
ACGTGCCTTACGCTACATCTTGTTTTCTAGGAAGAGGGGGATGCTGGGAAGGAATGGGTGCTTTGTGATGGATAAAAGGCATTAAATAAA
ACCACGTTTACATTTTGAA

>13946_13946_3_CCDC85A-EYA2_CCDC85A_chr2_56570090_ENST00000407595_EYA2_chr20_45771698_ENST00000327619_length(amino acids)=681AA_BP=438
MSKAAGGAAAAAAAAESCSPAPAGSSAAPPAPVEDLSKVSDEELLQWSKEELIRSLRRAEAEKVSAMLDHSNLIREVNRRLQLHLGEIRG
LKDINQKLQEDNQELRDLCCFLDDDRQKGKRVSREWQRLGRYTAGVMHKEVALYLQKLKDLEVKQEEVVKENMELKELCVLLDEEKGAGC
AGSRCSIDSQASLCQLTASTAPYVRDVGDGSSTSSTGSTDSPDHHKHHASSGSPEHLQKPRSEGSPEHSKHRSASPEHPQKPRACGTPDR
PKALKGPSPEHHKPLCKGSPEQQRHPHPGSSPETLPKHVLSGSPEHFQKHRSGSSPEHARHSGGSPEHLQKHALGGSLEHLPRARGTSPE
HLKQHYGGSPDHKHGGGSGGSGGSGGGSREGTLRRQAQEDGSPHHRNVYSGMNESTLSYVRQLEARVRQLEEENRMLPQDTTTSVRIGLM
MEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNN
VGGLIGTPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERI
MQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL

--------------------------------------------------------------
>13946_13946_4_CCDC85A-EYA2_CCDC85A_chr2_56570090_ENST00000407595_EYA2_chr20_45771698_ENST00000357410_length(transcript)=3022nt_BP=1819nt
GCGCCGCGGTGCCCGGCGCGCCCTCCAAGCTAGGAGAGGGGAGAAGCCGGGGGCTGCAGCTGGGCAAGGGGGAGGAAAGTGCGTGTGCGT
GCACGCCTGTGTGCAGGGCAGAGAGTGCGGGGGGCGACAGTCTCGGCTTAGGGCGGAGGAGAGGGCAGGGGAACGGCGGTGCAGCTCCCC
CGCTGTCCCCGAGGATTTCCCGCGGCAGCCCCGGGCTCCCCAGTGCCCCTCACCATGGACTTGCGCGGAGTTGGGACGGGCCTCGGCAGC
AGCAAGCGGCTGGCTGCCGGGCCCTGGGGGAGCGCGGGCGCGCGCGCGGGGATGGCGAGGTAGGATGGCCACCCAGCGCGACCCCCGCCG
CCCCAACCCAGCGGCCCCTGGGCGGTGCCGCTGACTCGCCGGAGCGCACAGGGGTGTGGGCGGAGGCGGCCTCGCCGCGCCCGCGCCTTC
GGGAGTCGCCTCGCCTCTTCCACCCACTTGCACCTGCCACCCCGCGGATACCATGTCGAAGGCGGCCGGAGGCGCGGCGGCGGCTGCGGC
GGCGGCGGAAAGTTGTTCCCCAGCCCCGGCCGGCTCGTCCGCGGCCCCGCCCGCGCCGGTGGAGGACCTGTCCAAAGTGTCGGACGAGGA
GCTGCTGCAGTGGAGCAAGGAGGAGCTGATCCGCAGCCTGCGGCGCGCCGAGGCGGAGAAGGTGAGCGCGATGCTGGACCACAGCAACCT
CATCCGCGAGGTGAACCGCCGCCTGCAGCTGCACCTCGGCGAGATCCGCGGCCTCAAGGATATCAACCAGAAACTCCAGGAAGACAACCA
GGAACTGAGGGACCTCTGCTGTTTCCTGGATGATGACCGGCAGAAAGGCAAGAGGGTGTCTCGGGAGTGGCAGAGACTGGGTCGCTACAC
TGCCGGGGTGATGCACAAGGAAGTGGCCTTATACCTGCAGAAGCTGAAAGACCTGGAGGTGAAGCAGGAGGAAGTGGTGAAGGAGAACAT
GGAGCTCAAGGAGCTCTGTGTGCTACTAGATGAGGAGAAGGGTGCAGGCTGCGCAGGCAGCCGCTGCTCCATCGACAGCCAGGCCAGCCT
GTGCCAACTCACAGCCTCCACCGCACCCTACGTGCGGGATGTGGGTGACGGCAGCAGCACCTCCAGCACTGGCAGCACTGACAGCCCGGA
CCACCACAAGCACCACGCGAGCAGTGGCAGCCCGGAGCACCTGCAGAAGCCCCGGAGCGAGGGCAGCCCGGAGCACTCCAAGCACAGGAG
CGCCAGCCCCGAGCATCCACAGAAACCCAGAGCCTGTGGAACCCCAGATCGCCCCAAAGCACTCAAAGGACCTAGCCCGGAGCACCACAA
ACCCTTGTGCAAGGGCAGCCCCGAACAGCAAAGGCACCCGCATCCAGGGAGCAGCCCCGAAACGCTGCCCAAGCACGTGCTGAGTGGGAG
CCCGGAACACTTCCAGAAGCACCGGTCAGGGAGCAGCCCTGAACACGCCAGGCACAGTGGAGGGAGCCCGGAGCATCTTCAGAAACACGC
TCTTGGGGGGAGCCTAGAGCATCTCCCCAGAGCCAGGGGCACCAGCCCGGAGCACCTCAAACAACATTATGGAGGGAGCCCTGATCACAA
ACACGGAGGAGGCAGTGGAGGAAGTGGAGGCAGCGGCGGAGGCAGCAGGGAGGGCACCCTCAGACGGCAGGCACAGGAGGACGGGTCACC
CCATCACCGGAATGTCTACAGTGGCATGAACGAATCAACCTTGTCCTATGTTAGGCAGCTGGAGGCAAGAGTAAGACAGCTGGAGGAAGA
AAATCGCATGCTGCCCCAGGACACCACGACGTCCGTGCGCATTGGCCTTATGATGGAAGAGATGATCTTCAACCTTGCAGATACACATCT
GTTCTTCAATGACCTGGAGGATTGTGACCAGATCCACGTTGATGACGTCTCATCAGATGACAATGGCCAAGATTTAAGCACATACAACTT
CTCCGCTGACGGCTTCCACAGTTCGGCCCCAGGAGCCAACCTGTGCCTGGGCTCTGGCGTGCACGGCGGCGTGGACTGGATGAGGAAGCT
GGCCTTCCGCTACCGGCGGGTGAAGGAGATGTACAATACCTACAAGAACAACGTTGGTGGGAAGGAGAGCTGCTTCGAGAGGATAATGCA
GAGATTCGGCAGAAAAGCTGTCTACGTGGTGATCGGTGATGGTGTGGAAGAGGAGCAAGGAGCGAAAAAGCACAACATGCCTTTCTGGCG
GATATCCTGCCACGCAGACCTGGAGGCACTGAGGCACGCCCTGGAGCTGGAGTATTTATAGCAGGATCAGCAGCATCTCCACCTGCCATC
TCACCCTCAGACCCCCTCGCCTTCCCCACCTCCCCACCGAGAACTCCAGAGACCCAGATGTTGGACACCAGGAAGGGGCCCCACAGCCGA
GACGACGTGTCCAGTGACCATCTCAGAAGCCGTCCATCAGTCCAAATGGGGGTTCTGAGAAGGAAAGTACCCAACATTGGCTTCGGAGTA
TTTGACTTTGGGGAAAAGGGCTGGCTCGGAGTCTAGACTCTTCTGTAAGACTCACAGAACAAAAGCAAGGAATTGCTGATTTGGGGGGTG
CCTGGTGATGAGGAGGGGATGGGTTTGTCTTGTCTTCTTTTTAATTTATGGACTAGTCTCATTACTCCGGAATTATGCTCTTGTACCTGT
GTGGCTGGGTTTCTTAGTCGTTGGTTTGGTTTGGTTTTTTGAACTGGTATGTGGGGTGGTTCACAGTTCTAATGTAAGCACTCTATTCTC
CAAGTTGTGCTTTGTGGGGACAATCATTCTTTGAACATTAGAGAGGAAGGCAGTTCAAGCTGTTGAAAAGACTATTGCTTATTTTTGTTT
TTAAAGACCTACTTGACGTCATGTGGACAGTGCACGTGCCTTACGCTACATCTTGTTTTCTAGGAAGAGGGGGATGCTGGGAAGGAATGG
GTGCTTTGTGATGGATAAAAGGCATTAAATAAAACCACGTTTACATTTTGAA

>13946_13946_4_CCDC85A-EYA2_CCDC85A_chr2_56570090_ENST00000407595_EYA2_chr20_45771698_ENST00000357410_length(amino acids)=602AA_BP=438
MSKAAGGAAAAAAAAESCSPAPAGSSAAPPAPVEDLSKVSDEELLQWSKEELIRSLRRAEAEKVSAMLDHSNLIREVNRRLQLHLGEIRG
LKDINQKLQEDNQELRDLCCFLDDDRQKGKRVSREWQRLGRYTAGVMHKEVALYLQKLKDLEVKQEEVVKENMELKELCVLLDEEKGAGC
AGSRCSIDSQASLCQLTASTAPYVRDVGDGSSTSSTGSTDSPDHHKHHASSGSPEHLQKPRSEGSPEHSKHRSASPEHPQKPRACGTPDR
PKALKGPSPEHHKPLCKGSPEQQRHPHPGSSPETLPKHVLSGSPEHFQKHRSGSSPEHARHSGGSPEHLQKHALGGSLEHLPRARGTSPE
HLKQHYGGSPDHKHGGGSGGSGGSGGGSREGTLRRQAQEDGSPHHRNVYSGMNESTLSYVRQLEARVRQLEEENRMLPQDTTTSVRIGLM
MEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNN
VGGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CCDC85A-EYA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCDC85A-EYA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCDC85A-EYA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource