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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C1QTNF3-CLPTM1L (FusionGDB2 ID:HG114899TG81037)

Fusion Gene Summary for C1QTNF3-CLPTM1L

check button Fusion gene summary
Fusion gene informationFusion gene name: C1QTNF3-CLPTM1L
Fusion gene ID: hg114899tg81037
HgeneTgene
Gene symbol

C1QTNF3

CLPTM1L

Gene ID

114899

81037

Gene nameC1q and TNF related 3CLPTM1 like
SynonymsC1ATNF3|CORCS|CORS|CORS-26|CORS26|CTRP3CRR9
Cytomap('C1QTNF3')('CLPTM1L')

5p13.2

5p15.33

Type of geneprotein-codingprotein-coding
Descriptioncomplement C1q tumor necrosis factor-related protein 3C1q and tumor necrosis factor related protein 3cartonectincollagenous repeat-containing sequence 26 kDa proteincollagenous repeat-containing sequence of 26-kDasecretory protein CORS26cleft lip and palate transmembrane protein 1-like proteinCLPTM1-like proteincisplatin resistance related protein CRR9pcisplatin resistance-related protein 9
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000231338, ENST00000382065, 
ENST00000513065, 
Fusion gene scores* DoF score2 X 2 X 2=815 X 11 X 8=1320
# samples 217
** MAII scorelog2(2/8*10)=1.32192809488736log2(17/1320*10)=-2.95693127810811
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C1QTNF3 [Title/Abstract] AND CLPTM1L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC1QTNF3(34028859)-CLPTM1L(1318568), # samples:3
Anticipated loss of major functional domain due to fusion event.C1QTNF3-CLPTM1L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C1QTNF3-CLPTM1L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C1QTNF3-CLPTM1L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C1QTNF3-CLPTM1L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneC1QTNF3

GO:0035356

cellular triglyceride homeostasis

20739398

HgeneC1QTNF3

GO:0045721

negative regulation of gluconeogenesis

20952387

HgeneC1QTNF3

GO:0050715

positive regulation of cytokine secretion

18421280

HgeneC1QTNF3

GO:0050728

negative regulation of inflammatory response

16213490

HgeneC1QTNF3

GO:0070165

positive regulation of adiponectin secretion

18421280

HgeneC1QTNF3

GO:0071638

negative regulation of monocyte chemotactic protein-1 production

20739398

HgeneC1QTNF3

GO:1900165

negative regulation of interleukin-6 secretion

16213490

HgeneC1QTNF3

GO:1901223

negative regulation of NIK/NF-kappaB signaling

16213490


check buttonFusion gene breakpoints across C1QTNF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CLPTM1L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRPTCGA-2Z-A9JJ-01AC1QTNF3chr5

34028859

-CLPTM1Lchr5

1318568

-
ChimerDB4KIRPTCGA-2Z-A9JJC1QTNF3chr5

34028859

-CLPTM1Lchr5

1318568

-


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Fusion Gene ORF analysis for C1QTNF3-CLPTM1L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000231338ENST00000506641C1QTNF3chr5

34028859

-CLPTM1Lchr5

1318568

-
5CDS-5UTRENST00000382065ENST00000506641C1QTNF3chr5

34028859

-CLPTM1Lchr5

1318568

-
5UTR-3CDSENST00000513065ENST00000320895C1QTNF3chr5

34028859

-CLPTM1Lchr5

1318568

-
5UTR-3CDSENST00000513065ENST00000320927C1QTNF3chr5

34028859

-CLPTM1Lchr5

1318568

-
5UTR-3CDSENST00000513065ENST00000507807C1QTNF3chr5

34028859

-CLPTM1Lchr5

1318568

-
5UTR-5UTRENST00000513065ENST00000506641C1QTNF3chr5

34028859

-CLPTM1Lchr5

1318568

-
Frame-shiftENST00000231338ENST00000320895C1QTNF3chr5

34028859

-CLPTM1Lchr5

1318568

-
Frame-shiftENST00000231338ENST00000507807C1QTNF3chr5

34028859

-CLPTM1Lchr5

1318568

-
Frame-shiftENST00000382065ENST00000320895C1QTNF3chr5

34028859

-CLPTM1Lchr5

1318568

-
Frame-shiftENST00000382065ENST00000507807C1QTNF3chr5

34028859

-CLPTM1Lchr5

1318568

-
In-frameENST00000231338ENST00000320927C1QTNF3chr5

34028859

-CLPTM1Lchr5

1318568

-
In-frameENST00000382065ENST00000320927C1QTNF3chr5

34028859

-CLPTM1Lchr5

1318568

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000382065C1QTNF3chr534028859-ENST00000320927CLPTM1Lchr51318568-199314073741435353
ENST00000231338C1QTNF3chr534028859-ENST00000320927CLPTM1Lchr51318568-115556910597195

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000382065ENST00000320927C1QTNF3chr534028859-CLPTM1Lchr51318568-0.0204403420.97955966
ENST00000231338ENST00000320927C1QTNF3chr534028859-CLPTM1Lchr51318568-0.0087149420.991285

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Fusion Genomic Features for C1QTNF3-CLPTM1L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for C1QTNF3-CLPTM1L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:34028859/chr5:1318568)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC1QTNF3chr5:34028859chr5:1318568ENST00000231338-4651_113160247.0DomainNote=Collagen-like
HgeneC1QTNF3chr5:34028859chr5:1318568ENST00000382065-4651_113233320.0DomainNote=Collagen-like

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC1QTNF3chr5:34028859chr5:1318568ENST00000231338-46113_246160247.0DomainC1q
HgeneC1QTNF3chr5:34028859chr5:1318568ENST00000382065-46113_246233320.0DomainC1q
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST0000032089515171_10510539.0Topological domainCytoplasmic
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST000003208951517306_324510539.0Topological domainCytoplasmic
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST00000320895151732_284510539.0Topological domainExtracellular
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST000003208951517343_346510539.0Topological domainExtracellular
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST000003208951517365_402510539.0Topological domainCytoplasmic
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST000003208951517424_428510539.0Topological domainExtracellular
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST000003208951517450_538510539.0Topological domainCytoplasmic
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST0000032092714161_10474503.0Topological domainCytoplasmic
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST000003209271416306_324474503.0Topological domainCytoplasmic
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST00000320927141632_284474503.0Topological domainExtracellular
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST000003209271416343_346474503.0Topological domainExtracellular
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST000003209271416365_402474503.0Topological domainCytoplasmic
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST000003209271416424_428474503.0Topological domainExtracellular
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST000003209271416450_538474503.0Topological domainCytoplasmic
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST00000320895151711_31510539.0TransmembraneHelical
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST000003208951517285_305510539.0TransmembraneHelical
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST000003208951517325_342510539.0TransmembraneHelical
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST000003208951517347_364510539.0TransmembraneHelical
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST000003208951517403_423510539.0TransmembraneHelical
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST000003208951517429_449510539.0TransmembraneHelical
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST00000320927141611_31474503.0TransmembraneHelical
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST000003209271416285_305474503.0TransmembraneHelical
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST000003209271416325_342474503.0TransmembraneHelical
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST000003209271416347_364474503.0TransmembraneHelical
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST000003209271416403_423474503.0TransmembraneHelical
TgeneCLPTM1Lchr5:34028859chr5:1318568ENST000003209271416429_449474503.0TransmembraneHelical


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Fusion Gene Sequence for C1QTNF3-CLPTM1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11432_11432_1_C1QTNF3-CLPTM1L_C1QTNF3_chr5_34028859_ENST00000231338_CLPTM1L_chr5_1318568_ENST00000320927_length(transcript)=1155nt_BP=569nt
AGCTCCAGTCCTGGCATCTGCCCGAGGAGACCACGCTCCTGGAGCTCTGCTGTCTTCTCAGGGAGACTCTGAGGCTCTGTTGAGAATCAT
GCTTTGGAGGCAGCTCATCTATTGGCAACTGCTGGCTTTGTTTTTCCTCCCTTTTTGCCTGTGTCAAGATGAATACATGGAGTCTCCACA
AACCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTACAGCTTTCGAGGCTACCAAGGCCCCCCTGGGCCACCGGGCCC
TCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAATGGAGCCACTGGTCATGAAGGAGCCAAAGGTGAGAAGGGCGACAAAGGTGA
CCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAGGGCTACCCGGGGATTCCACCAGAACTTCAGATTGCATTCAT
GGCTTCTCTGGCAACCCACTTCAGCAATCAGAACAGTGGGATTATCTTCAGCAGTGTTGAGACCAACATTGGAAACTTCTTTGATGTCAT
GACTGGTAGATTTGGGGCCCCAGTATCAGGCTTTATCCTGTGGATAAACGCAGAGTGAACGAGTTTGGGGAGTCCTACGAGGAGAAGGCC
ACGCGGGCGCCCCACACGGACTGAAGGCCGCCCGGGCTGCCGCCAGCCAAGTGCAACTTGAATTGTCAATGAGTATTTTTGGAAGCATTT
GGAGGAATTCCTAGACATTGCGTTTTCTGTGTTGCCAAAATCCCTTCGGACATTTCTCAGACATCTCCCAAGTTCCCATCACGTCAGATT
TGGAGCTGGTAGCGCTTACGATGCCCCCACGTGTGAACATCTGTCTTGGTCACAGAGCTGGGTGCTGCCGGTCACCTTGAGCTGTGGTGG
CTCCCGGCACACGAGTGTCCGGGGTTCGGCCATGTCCTCACGCGGGCAGGGGTGGGAGCCCTCACAGGCAAGGGGGCTGTTGGATTTCCA
TTTCAGGTGGTTTTCTAAGTGCTCCTTATGTGAATTTCAAACACGTATGGAATTCATTCCGCATGGACTCTGGGATCAAAGGCTCTTTCC

>11432_11432_1_C1QTNF3-CLPTM1L_C1QTNF3_chr5_34028859_ENST00000231338_CLPTM1L_chr5_1318568_ENST00000320927_length(amino acids)=195AA_BP=
MASARGDHAPGALLSSQGDSEALLRIMLWRQLIYWQLLALFFLPFCLCQDEYMESPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGI
PGNHGNNGNNGATGHEGAKGEKGDKGDLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNIGNFFDVMTGR

--------------------------------------------------------------
>11432_11432_2_C1QTNF3-CLPTM1L_C1QTNF3_chr5_34028859_ENST00000382065_CLPTM1L_chr5_1318568_ENST00000320927_length(transcript)=1993nt_BP=1407nt
TTTTGGCTTTTGGGAAGTCATGGGGAAAAGAAGTAAAGCTGAGGGTGGCGAAATACCTTTGCTAAACCCAGAGACACTGCACCTGAATCC
TGCTCAGTGTTTTGTAGGCAACCAACTGCCTTCTGCCACTGGTATCCGGAAGGGGAAATGAGTTACCTTAAGTGGGCCAAAGTGGGGAAA
TACTAACAGTACAGCTAGAAACCAAGAGCTGTCGTGAAAGCCCTGAATGGGTTCCCACTGCTATTTCAGACAAAACTGATGCAGTTAAGC
CTGAATTTCCTGGCAAGCACAAGGGTAGATTTTTCCAAAAGGCTTTTTAGACTGCAAATACACAGCCTTTCCATGTCTAATCACAAAAGC
AAACTGCTGGACACATGCTCTCTGTTCCCAGCTGGTTGTGTATGTTTTCTTCACACTTCAACAGAAACGTGCCAAGGTGTGACATTTATG
AATTTCGCCAACTGGGAACTGTGCACACAAATCGTTCTTGCTTGTGGTGTGGGAAAATGATGAATGGGGGCTGTTCTGCCTGGGGAGGAG
GGCTGCTGTCACTCTGGCATGCCTACAGCCTTATTTATTACACACCAAAGTATAAAACCACTCCGCCGCTGCAGCTCTCAGCTCCAGTCC
TGGCATCTGCCCGAGGAGACCACGCTCCTGGAGCTCTGCTGTCTTCTCAGGGAGACTCTGAGGCTCTGTTGAGAATCATGCTTTGGAGGC
AGCTCATCTATTGGCAACTGCTGGCTTTGTTTTTCCTCCCTTTTTGCCTGTGTCAAGATGAATACATGGAGGTGAGCGGAAGAACTAATA
AAGTGGTGGCAAGAATAGTGCAAAGCCACCAGCAGACTGGCCGTAGCGGCTCCAGGAGGGAGAAAGTGAGAGAGCGGAGCCATCCTAAAA
CTGGGACTGTGGATAATAACACTTCTACAGACCTAAAATCCCTGAGACCAGATGAGCTACCGCACCCCGAGGTAGATGACCTAGCCCAGA
TCACCACATTCTGGGGCCAGTCTCCACAAACCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTACAGCTTTCGAGGCT
ACCAAGGCCCCCCTGGGCCACCGGGCCCTCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAATGGAGCCACTGGTCATGAAGGAG
CCAAAGGTGAGAAGGGCGACAAAGGTGACCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAGGGCTACCCGGGGA
TTCCACCAGAACTTCAGATTGCATTCATGGCTTCTCTGGCAACCCACTTCAGCAATCAGAACAGTGGGATTATCTTCAGCAGTGTTGAGA
CCAACATTGGAAACTTCTTTGATGTCATGACTGGTAGATTTGGGGCCCCAGTATCAGGCTTTATCCTGTGGATAAACGCAGAGTGAACGA
GTTTGGGGAGTCCTACGAGGAGAAGGCCACGCGGGCGCCCCACACGGACTGAAGGCCGCCCGGGCTGCCGCCAGCCAAGTGCAACTTGAA
TTGTCAATGAGTATTTTTGGAAGCATTTGGAGGAATTCCTAGACATTGCGTTTTCTGTGTTGCCAAAATCCCTTCGGACATTTCTCAGAC
ATCTCCCAAGTTCCCATCACGTCAGATTTGGAGCTGGTAGCGCTTACGATGCCCCCACGTGTGAACATCTGTCTTGGTCACAGAGCTGGG
TGCTGCCGGTCACCTTGAGCTGTGGTGGCTCCCGGCACACGAGTGTCCGGGGTTCGGCCATGTCCTCACGCGGGCAGGGGTGGGAGCCCT
CACAGGCAAGGGGGCTGTTGGATTTCCATTTCAGGTGGTTTTCTAAGTGCTCCTTATGTGAATTTCAAACACGTATGGAATTCATTCCGC
ATGGACTCTGGGATCAAAGGCTCTTTCCTCTTTTGTTTGAGAGTTGGTTGTTTTAAAGCTTAATGTATGTTTCTATTTTAAAATAAATTT

>11432_11432_2_C1QTNF3-CLPTM1L_C1QTNF3_chr5_34028859_ENST00000382065_CLPTM1L_chr5_1318568_ENST00000320927_length(amino acids)=353AA_BP=
MLSVPSWLCMFSSHFNRNVPRCDIYEFRQLGTVHTNRSCLWCGKMMNGGCSAWGGGLLSLWHAYSLIYYTPKYKTTPPLQLSAPVLASAR
GDHAPGALLSSQGDSEALLRIMLWRQLIYWQLLALFFLPFCLCQDEYMEVSGRTNKVVARIVQSHQQTGRSGSRREKVRERSHPKTGTVD
NNTSTDLKSLRPDELPHPEVDDLAQITTFWGQSPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKGEK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for C1QTNF3-CLPTM1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C1QTNF3-CLPTM1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C1QTNF3-CLPTM1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0024121Lung Neoplasms3CTD_human
TgeneC0242379Malignant neoplasm of lung3CTD_human
TgeneC0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneC0005695Bladder Neoplasm1CTD_human
TgeneC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneC0007873Uterine Cervical Neoplasm1CTD_human
TgeneC0023448Lymphoid leukemia1CTD_human
TgeneC0026640Mouth Neoplasms1CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneC0153381Malignant neoplasm of mouth1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human
TgeneC1368275Pigmented Basal Cell Carcinoma1CTD_human
TgeneC4048328cervical cancer1CTD_human
TgeneC4721806Carcinoma, Basal Cell1CTD_human