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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CIRBP-MISP (FusionGDB2 ID:HG1153TG126353)

Fusion Gene Summary for CIRBP-MISP

check button Fusion gene summary
Fusion gene informationFusion gene name: CIRBP-MISP
Fusion gene ID: hg1153tg126353
HgeneTgene
Gene symbol

CIRBP

MISP

Gene ID

1153

126353

Gene namecold inducible RNA binding proteinmitotic spindle positioning
SynonymsCIRPC19orf21|MISP1
Cytomap('CIRBP')('MISP')

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptioncold-inducible RNA-binding proteinA18 hnRNPglycine-rich RNA binding proteintesticular tissue protein Li 39mitotic interactor and substrate of PLK1capricemitotic interactor and substrate of Plk1mitotic spindle positioning protein
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000320936, ENST00000413636, 
ENST00000444172, ENST00000586472, 
ENST00000587323, ENST00000587896, 
ENST00000588230, ENST00000589235, 
ENST00000589686, ENST00000589710, 
ENST00000585630, ENST00000586773, 
ENST00000588030, ENST00000588090, 
ENST00000589660, ENST00000590188, 
ENST00000591935, 
Fusion gene scores* DoF score12 X 7 X 6=5044 X 3 X 3=36
# samples 134
** MAII scorelog2(13/504*10)=-1.95491211047146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CIRBP [Title/Abstract] AND MISP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCIRBP(1269409)-MISP(756890), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCIRBP

GO:0009411

response to UV

11574538

HgeneCIRBP

GO:0045727

positive regulation of translation

11574538

HgeneCIRBP

GO:0048255

mRNA stabilization

11574538



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-8574-01ACIRBPchr19

1269409

+MISPchr19

756890

+


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Fusion Gene ORF analysis for CIRBP-MISP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000320936ENST00000215582CIRBPchr19

1269409

+MISPchr19

756890

+
5UTR-5UTRENST00000413636ENST00000215582CIRBPchr19

1269409

+MISPchr19

756890

+
5UTR-5UTRENST00000444172ENST00000215582CIRBPchr19

1269409

+MISPchr19

756890

+
5UTR-5UTRENST00000586472ENST00000215582CIRBPchr19

1269409

+MISPchr19

756890

+
5UTR-5UTRENST00000587323ENST00000215582CIRBPchr19

1269409

+MISPchr19

756890

+
5UTR-5UTRENST00000587896ENST00000215582CIRBPchr19

1269409

+MISPchr19

756890

+
5UTR-5UTRENST00000588230ENST00000215582CIRBPchr19

1269409

+MISPchr19

756890

+
5UTR-5UTRENST00000589235ENST00000215582CIRBPchr19

1269409

+MISPchr19

756890

+
5UTR-5UTRENST00000589686ENST00000215582CIRBPchr19

1269409

+MISPchr19

756890

+
5UTR-5UTRENST00000589710ENST00000215582CIRBPchr19

1269409

+MISPchr19

756890

+
intron-5UTRENST00000585630ENST00000215582CIRBPchr19

1269409

+MISPchr19

756890

+
intron-5UTRENST00000586773ENST00000215582CIRBPchr19

1269409

+MISPchr19

756890

+
intron-5UTRENST00000588030ENST00000215582CIRBPchr19

1269409

+MISPchr19

756890

+
intron-5UTRENST00000588090ENST00000215582CIRBPchr19

1269409

+MISPchr19

756890

+
intron-5UTRENST00000589660ENST00000215582CIRBPchr19

1269409

+MISPchr19

756890

+
intron-5UTRENST00000590188ENST00000215582CIRBPchr19

1269409

+MISPchr19

756890

+
intron-5UTRENST00000591935ENST00000215582CIRBPchr19

1269409

+MISPchr19

756890

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CIRBP-MISP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CIRBPchr191269406+MISPchr19756889+0.0010676440.9989323
CIRBPchr191269406+MISPchr19756889+0.0010676440.9989323


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CIRBP-MISP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:1269409/:756890)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CIRBP-MISP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CIRBP-MISP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CIRBP-MISP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CIRBP-MISP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCIRBPC0151744Myocardial Ischemia1CTD_human
HgeneCIRBPC0600467Neurogenic Inflammation1CTD_human
HgeneCIRBPC0751865Alcohol-Induced Disorders, Nervous System1CTD_human
HgeneCIRBPC1510586Autism Spectrum Disorders1CTD_human