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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AGAP1-ADAMTS2 (FusionGDB2 ID:HG116987TG9509)

Fusion Gene Summary for AGAP1-ADAMTS2

check button Fusion gene summary
Fusion gene informationFusion gene name: AGAP1-ADAMTS2
Fusion gene ID: hg116987tg9509
HgeneTgene
Gene symbol

AGAP1

ADAMTS2

Gene ID

116987

9509

Gene nameArfGAP with GTPase domain, ankyrin repeat and PH domain 1ADAM metallopeptidase with thrombospondin type 1 motif 2
SynonymsAGAP-1|CENTG2|GGAP1|cnt-g2ADAM-TS2|ADAMTS-2|ADAMTS-3|EDSDERMS|NPI|PC I-NP|PCI-NP|PCINP|PCPNI|PNPI
Cytomap('AGAP1')('ADAMTS2')

2q37.2

5q35.3

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with GTPase, ANK repeat and PH domain-containing protein 1Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 1GTP-binding and GTPase-activating protein 1centaurin, gamma 2A disintegrin and metalloproteinase with thrombospondin motifs 2a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2procollagen I N-proteinaseprocollagen I/II amino propeptide-processing enzymeprocollagen N-endo
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000304032, ENST00000336665, 
ENST00000409457, ENST00000409538, 
ENST00000428334, 
Fusion gene scores* DoF score49 X 18 X 17=149946 X 6 X 3=108
# samples 486
** MAII scorelog2(48/14994*10)=-4.96520709119934
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AGAP1 [Title/Abstract] AND ADAMTS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAGAP1(236653483)-ADAMTS2(178553131), # samples:1
Anticipated loss of major functional domain due to fusion event.AGAP1-ADAMTS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AGAP1-ADAMTS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AGAP1-ADAMTS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AGAP1-ADAMTS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across AGAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ADAMTS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HI-7168-01AAGAP1chr2

236653483

-ADAMTS2chr5

178553131

-


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Fusion Gene ORF analysis for AGAP1-ADAMTS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000304032ENST00000274609AGAP1chr2

236653483

-ADAMTS2chr5

178553131

-
5CDS-intronENST00000336665ENST00000274609AGAP1chr2

236653483

-ADAMTS2chr5

178553131

-
5CDS-intronENST00000409457ENST00000274609AGAP1chr2

236653483

-ADAMTS2chr5

178553131

-
5CDS-intronENST00000409538ENST00000274609AGAP1chr2

236653483

-ADAMTS2chr5

178553131

-
5CDS-intronENST00000428334ENST00000274609AGAP1chr2

236653483

-ADAMTS2chr5

178553131

-
In-frameENST00000304032ENST00000251582AGAP1chr2

236653483

-ADAMTS2chr5

178553131

-
In-frameENST00000336665ENST00000251582AGAP1chr2

236653483

-ADAMTS2chr5

178553131

-
In-frameENST00000409457ENST00000251582AGAP1chr2

236653483

-ADAMTS2chr5

178553131

-
In-frameENST00000409538ENST00000251582AGAP1chr2

236653483

-ADAMTS2chr5

178553131

-
In-frameENST00000428334ENST00000251582AGAP1chr2

236653483

-ADAMTS2chr5

178553131

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000336665AGAP1chr2236653483-ENST00000251582ADAMTS2chr5178553131-515311184212136571
ENST00000304032AGAP1chr2236653483-ENST00000251582ADAMTS2chr5178553131-515311184212136571
ENST00000409538AGAP1chr2236653483-ENST00000251582ADAMTS2chr5178553131-586418294182847809
ENST00000428334AGAP1chr2236653483-ENST00000251582ADAMTS2chr5178553131-411176211094357
ENST00000409457AGAP1chr2236653483-ENST00000251582ADAMTS2chr5178553131-517111364392154571

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336665ENST00000251582AGAP1chr2236653483-ADAMTS2chr5178553131-0.0043678180.9956321
ENST00000304032ENST00000251582AGAP1chr2236653483-ADAMTS2chr5178553131-0.0043678180.9956321
ENST00000409538ENST00000251582AGAP1chr2236653483-ADAMTS2chr5178553131-0.008824050.991176
ENST00000428334ENST00000251582AGAP1chr2236653483-ADAMTS2chr5178553131-0.0107431920.9892568
ENST00000409457ENST00000251582AGAP1chr2236653483-ADAMTS2chr5178553131-0.0044757040.9955243

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Fusion Genomic Features for AGAP1-ADAMTS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for AGAP1-ADAMTS2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:236653483/chr5:178553131)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGAP1chr2:236653483chr5:178553131ENST00000304032-518122_126179858.0Nucleotide bindingGTP
HgeneAGAP1chr2:236653483chr5:178553131ENST00000304032-518178_181179858.0Nucleotide bindingGTP
HgeneAGAP1chr2:236653483chr5:178553131ENST00000304032-51878_85179858.0Nucleotide bindingGTP
HgeneAGAP1chr2:236653483chr5:178553131ENST00000336665-517122_126179805.0Nucleotide bindingGTP
HgeneAGAP1chr2:236653483chr5:178553131ENST00000336665-517178_181179805.0Nucleotide bindingGTP
HgeneAGAP1chr2:236653483chr5:178553131ENST00000336665-51778_85179805.0Nucleotide bindingGTP
HgeneAGAP1chr2:236653483chr5:178553131ENST00000409457-510122_126179406.0Nucleotide bindingGTP
HgeneAGAP1chr2:236653483chr5:178553131ENST00000409457-510178_181179406.0Nucleotide bindingGTP
HgeneAGAP1chr2:236653483chr5:178553131ENST00000409457-51078_85179406.0Nucleotide bindingGTP
TgeneADAMTS2chr2:236653483chr5:178553131ENST00000274609011185_1880567.0Compositional biasNote=Poly-Glu
TgeneADAMTS2chr2:236653483chr5:178553131ENST0000027460901140_430567.0Compositional biasNote=Poly-Ala
TgeneADAMTS2chr2:236653483chr5:178553131ENST00000274609011618_7220567.0Compositional biasNote=Cys-rich
TgeneADAMTS2chr2:236653483chr5:178553131ENST0000025158216221059_10978721212.0DomainPLAC
TgeneADAMTS2chr2:236653483chr5:178553131ENST000002515821622914_9718721212.0DomainTSP type-1 3
TgeneADAMTS2chr2:236653483chr5:178553131ENST000002515821622975_10298721212.0DomainTSP type-1 4
TgeneADAMTS2chr2:236653483chr5:178553131ENST000002746090111059_10970567.0DomainPLAC
TgeneADAMTS2chr2:236653483chr5:178553131ENST00000274609011266_4700567.0DomainPeptidase M12B
TgeneADAMTS2chr2:236653483chr5:178553131ENST00000274609011480_5600567.0DomainNote=Disintegrin
TgeneADAMTS2chr2:236653483chr5:178553131ENST00000274609011561_6160567.0DomainTSP type-1 1
TgeneADAMTS2chr2:236653483chr5:178553131ENST00000274609011854_9120567.0DomainTSP type-1 2
TgeneADAMTS2chr2:236653483chr5:178553131ENST00000274609011914_9710567.0DomainTSP type-1 3
TgeneADAMTS2chr2:236653483chr5:178553131ENST00000274609011975_10290567.0DomainTSP type-1 4
TgeneADAMTS2chr2:236653483chr5:178553131ENST00000274609011691_6930567.0MotifCell attachment site
TgeneADAMTS2chr2:236653483chr5:178553131ENST00000274609011723_8510567.0RegionNote=Spacer

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGAP1chr2:236653483chr5:178553131ENST00000304032-518346_588179858.0DomainPH
HgeneAGAP1chr2:236653483chr5:178553131ENST00000304032-518609_729179858.0DomainArf-GAP
HgeneAGAP1chr2:236653483chr5:178553131ENST00000336665-517346_588179805.0DomainPH
HgeneAGAP1chr2:236653483chr5:178553131ENST00000336665-517609_729179805.0DomainArf-GAP
HgeneAGAP1chr2:236653483chr5:178553131ENST00000409457-510346_588179406.0DomainPH
HgeneAGAP1chr2:236653483chr5:178553131ENST00000409457-510609_729179406.0DomainArf-GAP
HgeneAGAP1chr2:236653483chr5:178553131ENST00000304032-51866_276179858.0RegionNote=Small GTPase-like
HgeneAGAP1chr2:236653483chr5:178553131ENST00000336665-51766_276179805.0RegionNote=Small GTPase-like
HgeneAGAP1chr2:236653483chr5:178553131ENST00000409457-51066_276179406.0RegionNote=Small GTPase-like
HgeneAGAP1chr2:236653483chr5:178553131ENST00000304032-518768_797179858.0RepeatNote=ANK 1
HgeneAGAP1chr2:236653483chr5:178553131ENST00000304032-518801_830179858.0RepeatNote=ANK 2
HgeneAGAP1chr2:236653483chr5:178553131ENST00000336665-517768_797179805.0RepeatNote=ANK 1
HgeneAGAP1chr2:236653483chr5:178553131ENST00000336665-517801_830179805.0RepeatNote=ANK 2
HgeneAGAP1chr2:236653483chr5:178553131ENST00000409457-510768_797179406.0RepeatNote=ANK 1
HgeneAGAP1chr2:236653483chr5:178553131ENST00000409457-510801_830179406.0RepeatNote=ANK 2
HgeneAGAP1chr2:236653483chr5:178553131ENST00000304032-518624_647179858.0Zinc fingerC4-type
HgeneAGAP1chr2:236653483chr5:178553131ENST00000336665-517624_647179805.0Zinc fingerC4-type
HgeneAGAP1chr2:236653483chr5:178553131ENST00000409457-510624_647179406.0Zinc fingerC4-type
TgeneADAMTS2chr2:236653483chr5:178553131ENST000002515821622185_1888721212.0Compositional biasNote=Poly-Glu
TgeneADAMTS2chr2:236653483chr5:178553131ENST00000251582162240_438721212.0Compositional biasNote=Poly-Ala
TgeneADAMTS2chr2:236653483chr5:178553131ENST000002515821622618_7228721212.0Compositional biasNote=Cys-rich
TgeneADAMTS2chr2:236653483chr5:178553131ENST000002515821622266_4708721212.0DomainPeptidase M12B
TgeneADAMTS2chr2:236653483chr5:178553131ENST000002515821622480_5608721212.0DomainNote=Disintegrin
TgeneADAMTS2chr2:236653483chr5:178553131ENST000002515821622561_6168721212.0DomainTSP type-1 1
TgeneADAMTS2chr2:236653483chr5:178553131ENST000002515821622854_9128721212.0DomainTSP type-1 2
TgeneADAMTS2chr2:236653483chr5:178553131ENST000002515821622691_6938721212.0MotifCell attachment site
TgeneADAMTS2chr2:236653483chr5:178553131ENST000002515821622723_8518721212.0RegionNote=Spacer


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Fusion Gene Sequence for AGAP1-ADAMTS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2759_2759_1_AGAP1-ADAMTS2_AGAP1_chr2_236653483_ENST00000304032_ADAMTS2_chr5_178553131_ENST00000251582_length(transcript)=5153nt_BP=1118nt
CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC
AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG
GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC
AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG
CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC
CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG
GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT
CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG
GGAGCACGTCATCGCCATCGAAGATGCCTTCGTGAACAGCCAGGAATGGACGCTGAGTCGATCTGTCCCGGAGCTCAAAGTGGGAATTGT
GGGTAACTTGGCCAGCGGCAAGTCTGCCCTGGTGCACCGGTACCTGACGGGCACATATGTCCAGGAGGAGTCTCCGGAAGGTGGCAGGTT
CAAGAAAGAGATTGTCGTTGATGGACAGAGCTATCTGCTGCTGATCAGAGATGAAGGGGGCCCCCCGGAGGCGCAGTTTGCCATGTGGGT
GGACGCTGTTATATTTGTCTTCAGCTTGGAGGATGAAATAAGTTTCCAGACCGTTTACCACTACTACAGTCGAATGGCCAACTATCGGAA
CACGAGCGAGATTCCTCTGGTTCTGGTGGGAACCCAGGGGTCCCAGTTCACCAAGTATGGCTGCCGCCGGAGGCTGGACCACAAGATGGT
ACACCGTGGCTTCTGTGCCGCCCTCTCGAAGCCCAAAGCCATCCGCAGAGCGTGCAACCCACAGGAATGCTCCCAGCCAGTGTGGGTCAC
AGGCGAATGGGAGCCATGTAGCCAGACCTGTGGGCGGACAGGCATGCAGGTGCGCTCCGTGCGCTGCATTCAGCCGCTACACGACAACAC
CACCCGCTCCGTGCACGCCAAGCACTGCAATGACGCCCGGCCCGAGAGCCGCCGGGCCTGCAGCCGCGAGCTCTGCCCTGGTCGTTGGCG
AGCCGGGCCCTGGTCCCAGTGCTCAGTAACCTGTGGCAACGGCACCCAGGAGCGGCCAGTGCTCTGCCGCACCGCGGACGACAGCTTCGG
CATCTGCCAGGAGGAGCGTCCTGAGACAGCGAGGACCTGCAGGCTTGGCCCCTGTCCCCGAAACATCTCAGATCCCTCCAAGAAGAGCTA
CGTAGTTCAGTGGCTGTCCCGCCCGGACCCCGACTCGCCCATCCGGAAGATCTCGTCAAAGGGCCACTGCCAAGGCGACAAGTCAATATT
CTGTAGGATGGAAGTCTTGTCCCGCTATTGCTCCATCCCAGGCTACAACAAGCTGTGCTGCAAGTCCTGTAACCTGTACAACAACCTCAC
CAACGTGGAGGGCAGGATAGAGCCACCGCCTGGGAAGCACAACGACATTGACGTGTTCATGCCTACCCTCCCAGTGCCCACTGTAGCCAT
GGAGGTGCGGCCATCACCAAGCACCCCCCTGGAGGTCCCTCTCAATGCCTCCAGCACCAATGCCACAGAGGATCACCCAGAAACCAATGC
CGTAGATGAACCCTACAAAATCCATGGCCTGGAAGATGAAGTCCAGCCACCCAACCTAATCCCTCGACGACCGAGCCCCTATGAAAAGAC
CAGAAACCAAAGAATCCAAGAGCTCATTGATGAGATGCGGAAGAAAGAGATGCTCGGAAAGTTCTAATAAAATGGAAAGATAGCATCCCT
AGCATTTTTTTCTTGCTTATAGAGATATTCCATGGGATAGCAAATCCTGTGTCATGGAGATGAAGTCAAAATTCCTGATTCCAAAAGGTT
TTGAGAAAACAAAGAGGGGGAATGACGTAAGAAAGATAGGCATGAGCATGTGGTAACTAGGTTAGCACGTGTGCTTCCCAGCCCAGGAGC
GACCAAATACTGTGGTGGCGTCAGGTGTGCAGTGGAGAGGAATATAGAGGCTGTATGGCCTCCCTCAGTGAGGGCAGGGCAAGAGGGATC
ACTCTGAGAGAACAAAAATAGGCCCCAAGTTGCTAAGCAGTGATTGGGAACCTTCCTTTCCTTGGCGGAGATGCATGACATTCCCTACCG
ATCCCCAGACACAGCCTGTGGGACTCTTAGGAGAAATGGTGATTTACTGAATAACTGACCCGTTGCCGAGATGAGTACAATGAAGTGGAG
GTGATGAACTCAAATCGTCTTCCAGGGCCAGGCGGCTGACCGGGGTGAGCGTAGTGGCCCGCTGGGGACCATGGCCGCCCTGACAGCCAC
ACCCACCTGGAGCTGACTTGGTTCTGGCTGTTGCTGCCACTGTGAAATCTGTATCTCTCTCCATCTCTGCTCTACTATCCCCGGCCTTGC
CAGACAGTGTTCTTTTTCGGAAGAAGTCTAGATTTTTGCATGAAAAAAACTCAATCTTTAAAGGTCGACTCAGAACATTTTAAGGAGGCC
TCCACTTGGTCTGATGCAGTCTTGCTAATTAAGAACTAAAGGCCTTCTGACCTTCTTGGTGCTCATGCTGTACGGCATCTGAATGTCTCG
ACCGAGTCTGAGCCGTGCAGCTGTCCTCCACCTGCGAAAGTAATGAGAATCCTATCACGGGACATAAGGATAGGTCTAAACAGGGTCCAT
GCCAAGAAAACAGTGGGGTGCTCTCCCAGGCCTCTCCCCTGTCCACTAACCCTGGCCTTGCCGGCTGCCTTCCAGGCTCTGGGGGAAGAG
CTCCTGCATTCTTCCCTGGCCACCTTGGCTCCAGGGCTCCCCAGAGAGCCTCTTCCCTCCCCAAGTACCTGAGAAAGATGAGAGAGGCAC
GTGCTCTGCTGGGAAGGTCCAGTGAGCGGTTCAAGGGCCTGGAATCTCCCTACGGCCAAGTCTAAGGGTTCTGGGATTCTGGGCTTTGTG
GGCTTTGCTTGCTTGCTGGGAATGGGCTTTCCCTGTCCCGCCCTGCCCCACCTCGCCTCTGTCTCTCAGAAGCTCCAGAACCCAGCAGTG
ACCTGCAAAATGTGGCCTCTGATGGGGGCTTAGGGTGGGAGATGGGGAGAGCCTACATTGTCTTTTGCTCCTTGAAAACTTTAATAGCTC
CTATTTTCCAGAGAATGGTGCTTTGTGAGCAACATGCGAGTAAGAGAGAAATAGGAGGAAGGGGGAGTAGGGGCGGATGGGAGAAGAGTG
GCTCATTTTTACCTCTCACTGCCTTGACATTTTGTGAACGTGAAGCTTAAACTTTCTGGGCTTACAAGACCCAGGGGCACGTCAGCTCCT
TAGATGGGCTCAGCCTGACACATAATTCTTAAACCTTTCCTGTTTAAGAAACTTCTAGAGGCTGTGTACTCTCACCAATCCTCTTCGAGA
ATTTGTTCATGTGTATTTCCCCATTATATGGATGAGGCTCAGGATAACAGCATAGTGGCTACCTTCTACTGAGTTTTGAGGTGCTAATAA
GTATGTTTGTCTGAGGCTGCACATGTGGGTGGCTCTGTGTGTATGATCCAAGGGACAAAATGACGATGTAGGAACCAGCAAGAACGGAAT
CTGGGCTGATGCTTCAGTCTCCACCTGGGTGATGGCTAGCCTCCCGCCCTCCACCACCGCATCCCACACGTGCTGCGCACTGTCCCCGTG
TCTCCTGGAGAACCAAACTGGAGAAAACCTTTCTGAGTATCTCTCATAGTACCCCTTCCTTAAGAAGATGTGGTTTAGAGCATGTGTGCA
ATCCTGCCTCTGTAATTAGGAAACGGAGCCCGAGGCTTTCCATTGTTGGTTGAACCCAGGACAGCTGGTGCTATTCACAGGCTGAAGAAC
TGGGCAGTTCTTACTTGGGTCTGTCCTAGGATGTGGAGGAAGTTCAGGACTAACGCTAGGCAGAGAGTATGACTCGGTTTACCCAGCCTA
GGGGCCTCTGGATGGGAACACTCCATTCCAAGATCTCAGCAGAGCAGGGCTTCCTGGCTTGAGGCTGGAAGCCTTTGGGAAGAGGCCCAG
CTGGGACATTCCCTGGGCACCTGTCTTCCGCTGAAGGGAGCAAGGTGCCCTCTGGGACTGACAGCCATGACCCTCTGTGCCATCCTCAAT
CCTTGAGCCATATATCAAGAGTCCTCTAGAGCCGGATGGTCCTCAAAAGTCTGTCCAAGGAATGCCAACGTTCACCGGGCTCTGAGAAAC
GACGCAAATCTCTGAGCTGGGGACCACTTGGAGAACCGGCTTAGTAACAGTCCTGATCTTCGCAAGCCAGCTTCTTCTGCATCTGAGGGG
CTCCTGGCGCCCAGAGGAGGCAGACAGATGTCTTCTAGCTGAGTTTCTAACCGCATGATGAGACTCAGACCTTCCGCTGCACTAGAAAAT
CTGCAACAGTGTCCCTGAGTCACTTCTCCTTAGTGGGCAGACTCGTGTTAGATTTGTGGAACCCAGCTCTCTGATTTACTCCTTTTGGAA
AACCCATGGAATTTCATGTATAAGGCTTTCATTTGTATTTTAAGGTTTTTCTGTTTGTTTTGAGTATATACATGGTGCTCAATAGCAACA
TCTTAGCAGATGAAGCAGTTTATGATTCCACTCCCTCCTGTATGACAGGTAGCCACTATACTGAATCAAGGTGCTGAACTCAAATCACAA
AATTCTGGCTTACCGATACAACAACCAATACATCTTTGTTCTGTAATGTAAAATTTGACTCCTTACTTTTATAACTTATTAAAGTTAAAA

>2759_2759_1_AGAP1-ADAMTS2_AGAP1_chr2_236653483_ENST00000304032_ADAMTS2_chr5_178553131_ENST00000251582_length(amino acids)=571AA_BP=5
MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERV
EEPVLQNQIREHVIAIEDAFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGG
PPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNP
QECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPV
LCRTADDSFGICQEERPETARTCRLGPCPRNISDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPGYNKLCC
KSCNLYNNLTNVEGRIEPPPGKHNDIDVFMPTLPVPTVAMEVRPSPSTPLEVPLNASSTNATEDHPETNAVDEPYKIHGLEDEVQPPNLI

--------------------------------------------------------------
>2759_2759_2_AGAP1-ADAMTS2_AGAP1_chr2_236653483_ENST00000336665_ADAMTS2_chr5_178553131_ENST00000251582_length(transcript)=5153nt_BP=1118nt
CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC
AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG
GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC
AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG
CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC
CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG
GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT
CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG
GGAGCACGTCATCGCCATCGAAGATGCCTTCGTGAACAGCCAGGAATGGACGCTGAGTCGATCTGTCCCGGAGCTCAAAGTGGGAATTGT
GGGTAACTTGGCCAGCGGCAAGTCTGCCCTGGTGCACCGGTACCTGACGGGCACATATGTCCAGGAGGAGTCTCCGGAAGGTGGCAGGTT
CAAGAAAGAGATTGTCGTTGATGGACAGAGCTATCTGCTGCTGATCAGAGATGAAGGGGGCCCCCCGGAGGCGCAGTTTGCCATGTGGGT
GGACGCTGTTATATTTGTCTTCAGCTTGGAGGATGAAATAAGTTTCCAGACCGTTTACCACTACTACAGTCGAATGGCCAACTATCGGAA
CACGAGCGAGATTCCTCTGGTTCTGGTGGGAACCCAGGGGTCCCAGTTCACCAAGTATGGCTGCCGCCGGAGGCTGGACCACAAGATGGT
ACACCGTGGCTTCTGTGCCGCCCTCTCGAAGCCCAAAGCCATCCGCAGAGCGTGCAACCCACAGGAATGCTCCCAGCCAGTGTGGGTCAC
AGGCGAATGGGAGCCATGTAGCCAGACCTGTGGGCGGACAGGCATGCAGGTGCGCTCCGTGCGCTGCATTCAGCCGCTACACGACAACAC
CACCCGCTCCGTGCACGCCAAGCACTGCAATGACGCCCGGCCCGAGAGCCGCCGGGCCTGCAGCCGCGAGCTCTGCCCTGGTCGTTGGCG
AGCCGGGCCCTGGTCCCAGTGCTCAGTAACCTGTGGCAACGGCACCCAGGAGCGGCCAGTGCTCTGCCGCACCGCGGACGACAGCTTCGG
CATCTGCCAGGAGGAGCGTCCTGAGACAGCGAGGACCTGCAGGCTTGGCCCCTGTCCCCGAAACATCTCAGATCCCTCCAAGAAGAGCTA
CGTAGTTCAGTGGCTGTCCCGCCCGGACCCCGACTCGCCCATCCGGAAGATCTCGTCAAAGGGCCACTGCCAAGGCGACAAGTCAATATT
CTGTAGGATGGAAGTCTTGTCCCGCTATTGCTCCATCCCAGGCTACAACAAGCTGTGCTGCAAGTCCTGTAACCTGTACAACAACCTCAC
CAACGTGGAGGGCAGGATAGAGCCACCGCCTGGGAAGCACAACGACATTGACGTGTTCATGCCTACCCTCCCAGTGCCCACTGTAGCCAT
GGAGGTGCGGCCATCACCAAGCACCCCCCTGGAGGTCCCTCTCAATGCCTCCAGCACCAATGCCACAGAGGATCACCCAGAAACCAATGC
CGTAGATGAACCCTACAAAATCCATGGCCTGGAAGATGAAGTCCAGCCACCCAACCTAATCCCTCGACGACCGAGCCCCTATGAAAAGAC
CAGAAACCAAAGAATCCAAGAGCTCATTGATGAGATGCGGAAGAAAGAGATGCTCGGAAAGTTCTAATAAAATGGAAAGATAGCATCCCT
AGCATTTTTTTCTTGCTTATAGAGATATTCCATGGGATAGCAAATCCTGTGTCATGGAGATGAAGTCAAAATTCCTGATTCCAAAAGGTT
TTGAGAAAACAAAGAGGGGGAATGACGTAAGAAAGATAGGCATGAGCATGTGGTAACTAGGTTAGCACGTGTGCTTCCCAGCCCAGGAGC
GACCAAATACTGTGGTGGCGTCAGGTGTGCAGTGGAGAGGAATATAGAGGCTGTATGGCCTCCCTCAGTGAGGGCAGGGCAAGAGGGATC
ACTCTGAGAGAACAAAAATAGGCCCCAAGTTGCTAAGCAGTGATTGGGAACCTTCCTTTCCTTGGCGGAGATGCATGACATTCCCTACCG
ATCCCCAGACACAGCCTGTGGGACTCTTAGGAGAAATGGTGATTTACTGAATAACTGACCCGTTGCCGAGATGAGTACAATGAAGTGGAG
GTGATGAACTCAAATCGTCTTCCAGGGCCAGGCGGCTGACCGGGGTGAGCGTAGTGGCCCGCTGGGGACCATGGCCGCCCTGACAGCCAC
ACCCACCTGGAGCTGACTTGGTTCTGGCTGTTGCTGCCACTGTGAAATCTGTATCTCTCTCCATCTCTGCTCTACTATCCCCGGCCTTGC
CAGACAGTGTTCTTTTTCGGAAGAAGTCTAGATTTTTGCATGAAAAAAACTCAATCTTTAAAGGTCGACTCAGAACATTTTAAGGAGGCC
TCCACTTGGTCTGATGCAGTCTTGCTAATTAAGAACTAAAGGCCTTCTGACCTTCTTGGTGCTCATGCTGTACGGCATCTGAATGTCTCG
ACCGAGTCTGAGCCGTGCAGCTGTCCTCCACCTGCGAAAGTAATGAGAATCCTATCACGGGACATAAGGATAGGTCTAAACAGGGTCCAT
GCCAAGAAAACAGTGGGGTGCTCTCCCAGGCCTCTCCCCTGTCCACTAACCCTGGCCTTGCCGGCTGCCTTCCAGGCTCTGGGGGAAGAG
CTCCTGCATTCTTCCCTGGCCACCTTGGCTCCAGGGCTCCCCAGAGAGCCTCTTCCCTCCCCAAGTACCTGAGAAAGATGAGAGAGGCAC
GTGCTCTGCTGGGAAGGTCCAGTGAGCGGTTCAAGGGCCTGGAATCTCCCTACGGCCAAGTCTAAGGGTTCTGGGATTCTGGGCTTTGTG
GGCTTTGCTTGCTTGCTGGGAATGGGCTTTCCCTGTCCCGCCCTGCCCCACCTCGCCTCTGTCTCTCAGAAGCTCCAGAACCCAGCAGTG
ACCTGCAAAATGTGGCCTCTGATGGGGGCTTAGGGTGGGAGATGGGGAGAGCCTACATTGTCTTTTGCTCCTTGAAAACTTTAATAGCTC
CTATTTTCCAGAGAATGGTGCTTTGTGAGCAACATGCGAGTAAGAGAGAAATAGGAGGAAGGGGGAGTAGGGGCGGATGGGAGAAGAGTG
GCTCATTTTTACCTCTCACTGCCTTGACATTTTGTGAACGTGAAGCTTAAACTTTCTGGGCTTACAAGACCCAGGGGCACGTCAGCTCCT
TAGATGGGCTCAGCCTGACACATAATTCTTAAACCTTTCCTGTTTAAGAAACTTCTAGAGGCTGTGTACTCTCACCAATCCTCTTCGAGA
ATTTGTTCATGTGTATTTCCCCATTATATGGATGAGGCTCAGGATAACAGCATAGTGGCTACCTTCTACTGAGTTTTGAGGTGCTAATAA
GTATGTTTGTCTGAGGCTGCACATGTGGGTGGCTCTGTGTGTATGATCCAAGGGACAAAATGACGATGTAGGAACCAGCAAGAACGGAAT
CTGGGCTGATGCTTCAGTCTCCACCTGGGTGATGGCTAGCCTCCCGCCCTCCACCACCGCATCCCACACGTGCTGCGCACTGTCCCCGTG
TCTCCTGGAGAACCAAACTGGAGAAAACCTTTCTGAGTATCTCTCATAGTACCCCTTCCTTAAGAAGATGTGGTTTAGAGCATGTGTGCA
ATCCTGCCTCTGTAATTAGGAAACGGAGCCCGAGGCTTTCCATTGTTGGTTGAACCCAGGACAGCTGGTGCTATTCACAGGCTGAAGAAC
TGGGCAGTTCTTACTTGGGTCTGTCCTAGGATGTGGAGGAAGTTCAGGACTAACGCTAGGCAGAGAGTATGACTCGGTTTACCCAGCCTA
GGGGCCTCTGGATGGGAACACTCCATTCCAAGATCTCAGCAGAGCAGGGCTTCCTGGCTTGAGGCTGGAAGCCTTTGGGAAGAGGCCCAG
CTGGGACATTCCCTGGGCACCTGTCTTCCGCTGAAGGGAGCAAGGTGCCCTCTGGGACTGACAGCCATGACCCTCTGTGCCATCCTCAAT
CCTTGAGCCATATATCAAGAGTCCTCTAGAGCCGGATGGTCCTCAAAAGTCTGTCCAAGGAATGCCAACGTTCACCGGGCTCTGAGAAAC
GACGCAAATCTCTGAGCTGGGGACCACTTGGAGAACCGGCTTAGTAACAGTCCTGATCTTCGCAAGCCAGCTTCTTCTGCATCTGAGGGG
CTCCTGGCGCCCAGAGGAGGCAGACAGATGTCTTCTAGCTGAGTTTCTAACCGCATGATGAGACTCAGACCTTCCGCTGCACTAGAAAAT
CTGCAACAGTGTCCCTGAGTCACTTCTCCTTAGTGGGCAGACTCGTGTTAGATTTGTGGAACCCAGCTCTCTGATTTACTCCTTTTGGAA
AACCCATGGAATTTCATGTATAAGGCTTTCATTTGTATTTTAAGGTTTTTCTGTTTGTTTTGAGTATATACATGGTGCTCAATAGCAACA
TCTTAGCAGATGAAGCAGTTTATGATTCCACTCCCTCCTGTATGACAGGTAGCCACTATACTGAATCAAGGTGCTGAACTCAAATCACAA
AATTCTGGCTTACCGATACAACAACCAATACATCTTTGTTCTGTAATGTAAAATTTGACTCCTTACTTTTATAACTTATTAAAGTTAAAA

>2759_2759_2_AGAP1-ADAMTS2_AGAP1_chr2_236653483_ENST00000336665_ADAMTS2_chr5_178553131_ENST00000251582_length(amino acids)=571AA_BP=5
MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERV
EEPVLQNQIREHVIAIEDAFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGG
PPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNP
QECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPV
LCRTADDSFGICQEERPETARTCRLGPCPRNISDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPGYNKLCC
KSCNLYNNLTNVEGRIEPPPGKHNDIDVFMPTLPVPTVAMEVRPSPSTPLEVPLNASSTNATEDHPETNAVDEPYKIHGLEDEVQPPNLI

--------------------------------------------------------------
>2759_2759_3_AGAP1-ADAMTS2_AGAP1_chr2_236653483_ENST00000409457_ADAMTS2_chr5_178553131_ENST00000251582_length(transcript)=5171nt_BP=1136nt
GGCGCTCGGAGCGGGCTCCGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCC
CGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGC
CCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGC
TCAGGAAGTCACCCGAGCAAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGC
TGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCC
GCGCCTTTCTTCTCGCGCCTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCC
CCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGC
TGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGT
GCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATGCCTTCGTGAACAGCCAGGAATGGACGCTGAGTCGATCTGTCCCGGA
GCTCAAAGTGGGAATTGTGGGTAACTTGGCCAGCGGCAAGTCTGCCCTGGTGCACCGGTACCTGACGGGCACATATGTCCAGGAGGAGTC
TCCGGAAGGTGGCAGGTTCAAGAAAGAGATTGTCGTTGATGGACAGAGCTATCTGCTGCTGATCAGAGATGAAGGGGGCCCCCCGGAGGC
GCAGTTTGCCATGTGGGTGGACGCTGTTATATTTGTCTTCAGCTTGGAGGATGAAATAAGTTTCCAGACCGTTTACCACTACTACAGTCG
AATGGCCAACTATCGGAACACGAGCGAGATTCCTCTGGTTCTGGTGGGAACCCAGGGGTCCCAGTTCACCAAGTATGGCTGCCGCCGGAG
GCTGGACCACAAGATGGTACACCGTGGCTTCTGTGCCGCCCTCTCGAAGCCCAAAGCCATCCGCAGAGCGTGCAACCCACAGGAATGCTC
CCAGCCAGTGTGGGTCACAGGCGAATGGGAGCCATGTAGCCAGACCTGTGGGCGGACAGGCATGCAGGTGCGCTCCGTGCGCTGCATTCA
GCCGCTACACGACAACACCACCCGCTCCGTGCACGCCAAGCACTGCAATGACGCCCGGCCCGAGAGCCGCCGGGCCTGCAGCCGCGAGCT
CTGCCCTGGTCGTTGGCGAGCCGGGCCCTGGTCCCAGTGCTCAGTAACCTGTGGCAACGGCACCCAGGAGCGGCCAGTGCTCTGCCGCAC
CGCGGACGACAGCTTCGGCATCTGCCAGGAGGAGCGTCCTGAGACAGCGAGGACCTGCAGGCTTGGCCCCTGTCCCCGAAACATCTCAGA
TCCCTCCAAGAAGAGCTACGTAGTTCAGTGGCTGTCCCGCCCGGACCCCGACTCGCCCATCCGGAAGATCTCGTCAAAGGGCCACTGCCA
AGGCGACAAGTCAATATTCTGTAGGATGGAAGTCTTGTCCCGCTATTGCTCCATCCCAGGCTACAACAAGCTGTGCTGCAAGTCCTGTAA
CCTGTACAACAACCTCACCAACGTGGAGGGCAGGATAGAGCCACCGCCTGGGAAGCACAACGACATTGACGTGTTCATGCCTACCCTCCC
AGTGCCCACTGTAGCCATGGAGGTGCGGCCATCACCAAGCACCCCCCTGGAGGTCCCTCTCAATGCCTCCAGCACCAATGCCACAGAGGA
TCACCCAGAAACCAATGCCGTAGATGAACCCTACAAAATCCATGGCCTGGAAGATGAAGTCCAGCCACCCAACCTAATCCCTCGACGACC
GAGCCCCTATGAAAAGACCAGAAACCAAAGAATCCAAGAGCTCATTGATGAGATGCGGAAGAAAGAGATGCTCGGAAAGTTCTAATAAAA
TGGAAAGATAGCATCCCTAGCATTTTTTTCTTGCTTATAGAGATATTCCATGGGATAGCAAATCCTGTGTCATGGAGATGAAGTCAAAAT
TCCTGATTCCAAAAGGTTTTGAGAAAACAAAGAGGGGGAATGACGTAAGAAAGATAGGCATGAGCATGTGGTAACTAGGTTAGCACGTGT
GCTTCCCAGCCCAGGAGCGACCAAATACTGTGGTGGCGTCAGGTGTGCAGTGGAGAGGAATATAGAGGCTGTATGGCCTCCCTCAGTGAG
GGCAGGGCAAGAGGGATCACTCTGAGAGAACAAAAATAGGCCCCAAGTTGCTAAGCAGTGATTGGGAACCTTCCTTTCCTTGGCGGAGAT
GCATGACATTCCCTACCGATCCCCAGACACAGCCTGTGGGACTCTTAGGAGAAATGGTGATTTACTGAATAACTGACCCGTTGCCGAGAT
GAGTACAATGAAGTGGAGGTGATGAACTCAAATCGTCTTCCAGGGCCAGGCGGCTGACCGGGGTGAGCGTAGTGGCCCGCTGGGGACCAT
GGCCGCCCTGACAGCCACACCCACCTGGAGCTGACTTGGTTCTGGCTGTTGCTGCCACTGTGAAATCTGTATCTCTCTCCATCTCTGCTC
TACTATCCCCGGCCTTGCCAGACAGTGTTCTTTTTCGGAAGAAGTCTAGATTTTTGCATGAAAAAAACTCAATCTTTAAAGGTCGACTCA
GAACATTTTAAGGAGGCCTCCACTTGGTCTGATGCAGTCTTGCTAATTAAGAACTAAAGGCCTTCTGACCTTCTTGGTGCTCATGCTGTA
CGGCATCTGAATGTCTCGACCGAGTCTGAGCCGTGCAGCTGTCCTCCACCTGCGAAAGTAATGAGAATCCTATCACGGGACATAAGGATA
GGTCTAAACAGGGTCCATGCCAAGAAAACAGTGGGGTGCTCTCCCAGGCCTCTCCCCTGTCCACTAACCCTGGCCTTGCCGGCTGCCTTC
CAGGCTCTGGGGGAAGAGCTCCTGCATTCTTCCCTGGCCACCTTGGCTCCAGGGCTCCCCAGAGAGCCTCTTCCCTCCCCAAGTACCTGA
GAAAGATGAGAGAGGCACGTGCTCTGCTGGGAAGGTCCAGTGAGCGGTTCAAGGGCCTGGAATCTCCCTACGGCCAAGTCTAAGGGTTCT
GGGATTCTGGGCTTTGTGGGCTTTGCTTGCTTGCTGGGAATGGGCTTTCCCTGTCCCGCCCTGCCCCACCTCGCCTCTGTCTCTCAGAAG
CTCCAGAACCCAGCAGTGACCTGCAAAATGTGGCCTCTGATGGGGGCTTAGGGTGGGAGATGGGGAGAGCCTACATTGTCTTTTGCTCCT
TGAAAACTTTAATAGCTCCTATTTTCCAGAGAATGGTGCTTTGTGAGCAACATGCGAGTAAGAGAGAAATAGGAGGAAGGGGGAGTAGGG
GCGGATGGGAGAAGAGTGGCTCATTTTTACCTCTCACTGCCTTGACATTTTGTGAACGTGAAGCTTAAACTTTCTGGGCTTACAAGACCC
AGGGGCACGTCAGCTCCTTAGATGGGCTCAGCCTGACACATAATTCTTAAACCTTTCCTGTTTAAGAAACTTCTAGAGGCTGTGTACTCT
CACCAATCCTCTTCGAGAATTTGTTCATGTGTATTTCCCCATTATATGGATGAGGCTCAGGATAACAGCATAGTGGCTACCTTCTACTGA
GTTTTGAGGTGCTAATAAGTATGTTTGTCTGAGGCTGCACATGTGGGTGGCTCTGTGTGTATGATCCAAGGGACAAAATGACGATGTAGG
AACCAGCAAGAACGGAATCTGGGCTGATGCTTCAGTCTCCACCTGGGTGATGGCTAGCCTCCCGCCCTCCACCACCGCATCCCACACGTG
CTGCGCACTGTCCCCGTGTCTCCTGGAGAACCAAACTGGAGAAAACCTTTCTGAGTATCTCTCATAGTACCCCTTCCTTAAGAAGATGTG
GTTTAGAGCATGTGTGCAATCCTGCCTCTGTAATTAGGAAACGGAGCCCGAGGCTTTCCATTGTTGGTTGAACCCAGGACAGCTGGTGCT
ATTCACAGGCTGAAGAACTGGGCAGTTCTTACTTGGGTCTGTCCTAGGATGTGGAGGAAGTTCAGGACTAACGCTAGGCAGAGAGTATGA
CTCGGTTTACCCAGCCTAGGGGCCTCTGGATGGGAACACTCCATTCCAAGATCTCAGCAGAGCAGGGCTTCCTGGCTTGAGGCTGGAAGC
CTTTGGGAAGAGGCCCAGCTGGGACATTCCCTGGGCACCTGTCTTCCGCTGAAGGGAGCAAGGTGCCCTCTGGGACTGACAGCCATGACC
CTCTGTGCCATCCTCAATCCTTGAGCCATATATCAAGAGTCCTCTAGAGCCGGATGGTCCTCAAAAGTCTGTCCAAGGAATGCCAACGTT
CACCGGGCTCTGAGAAACGACGCAAATCTCTGAGCTGGGGACCACTTGGAGAACCGGCTTAGTAACAGTCCTGATCTTCGCAAGCCAGCT
TCTTCTGCATCTGAGGGGCTCCTGGCGCCCAGAGGAGGCAGACAGATGTCTTCTAGCTGAGTTTCTAACCGCATGATGAGACTCAGACCT
TCCGCTGCACTAGAAAATCTGCAACAGTGTCCCTGAGTCACTTCTCCTTAGTGGGCAGACTCGTGTTAGATTTGTGGAACCCAGCTCTCT
GATTTACTCCTTTTGGAAAACCCATGGAATTTCATGTATAAGGCTTTCATTTGTATTTTAAGGTTTTTCTGTTTGTTTTGAGTATATACA
TGGTGCTCAATAGCAACATCTTAGCAGATGAAGCAGTTTATGATTCCACTCCCTCCTGTATGACAGGTAGCCACTATACTGAATCAAGGT
GCTGAACTCAAATCACAAAATTCTGGCTTACCGATACAACAACCAATACATCTTTGTTCTGTAATGTAAAATTTGACTCCTTACTTTTAT

>2759_2759_3_AGAP1-ADAMTS2_AGAP1_chr2_236653483_ENST00000409457_ADAMTS2_chr5_178553131_ENST00000251582_length(amino acids)=571AA_BP=5
MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERV
EEPVLQNQIREHVIAIEDAFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGG
PPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNP
QECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPV
LCRTADDSFGICQEERPETARTCRLGPCPRNISDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPGYNKLCC
KSCNLYNNLTNVEGRIEPPPGKHNDIDVFMPTLPVPTVAMEVRPSPSTPLEVPLNASSTNATEDHPETNAVDEPYKIHGLEDEVQPPNLI

--------------------------------------------------------------
>2759_2759_4_AGAP1-ADAMTS2_AGAP1_chr2_236653483_ENST00000409538_ADAMTS2_chr5_178553131_ENST00000251582_length(transcript)=5864nt_BP=1829nt
GCGCGTTTCCATTTTAAACCGCCGCCCGCCGCCCGCCACCCGCCACCCTTCGGCCGCAGCCGGTGCAGCTGTCCGCGCGTCCCGGAGCCC
AGGGAGTGGCGGAGGCTGCGGAACCGCCGAGCTGTGCAGCCGGAGCGGGAGGATGCGCACGGGCCCCGCGTCGTAGACAATGAAGCCGCG
GGCGCCGCCGCCTGCCCTGGGCCCTGCGCACCGCGGCCGCACCTGCCGGCGAGAGCGCTCTAGCGCCTGACCGGCCGCCTCGCTTGGCCC
CGCCGGCCCATGGCTCGGCGCCCCGGGCCCGGACCCCGGCACTCGGGCGGCGCGGCGCACGGGCCGGCGGGTGCCAGGGGCGCCGTCCCC
GCAGCCTGAGTGCGGCCCTCGCGGTCAGCGGGGGGCGTGGGCCACACTCCCGGCCCGCCTGCCCTCCCCGCTTGGCCCGGCGCCCTCCCG
GCCCGCGGGCTCGCTGGATGCGGCGGGGCCCCAGCGCGCGGGCGACATGTACTTGTTGGACGGCAGTGGCGAGCCCGCGTCGCCACCCGC
GGACGCGATGCCGCGCGGGACGCCCCCCAGAAAGACTGTCTACCGCATCTCCGTGACCATGGTCAGGAAGGAGCAGCTGGCCGCGCCGGG
CTCCGGCGGCCCGGACCCACGCCCGGTTCGGCGGCCCCGGCCCGCGCGCTCCCCGGACGCGCCCGGGAGGCTTGAGGAGGAGGCCGAGGA
GGCGGAGGGCGCCGAGGAACCGGAGGGTCCCCGGCCGCGCGCTTGGGATTTCCGCACCTTCCGCACCCGCAGCACCGGGCAGCTGGAACT
GGGGCGGCTCCGGCCGTGCGCACGCGGCCTGGAACCCGCGGACCTGGCCGGCAGCGCCCCGGCCGAGGAGGAGGGACGCGGCTCGCCCGC
GTCCGGCAGCCCCGACGTGGAGGGGGCCCGGGCCGCGCCCCTGCGGCGGAGCCTGAGCTTCAGGCACTGGAGCGGGCCTGAGGCGCCGCA
AGGCCGGACACTGGGCGGCGGAAGGCGCCACAGCAGCTCCGGGAGCCTGGCCTGGGCGCCGTGCGACGAGGCCGCGGCCGGGACCACCCT
GGAGCCCGCGACCGCCACGCAGCCCGCCTCGGAGAAGCGCAACACCCTGGACGTGGGCGAGGTGCTCAGCAAGAACGACGCGCTCTCGGA
CCTGGAGCGTTGGGAACGCAGTAAGAGCAAGAACCGCACGCTGGACAACAGCGACCTGCAGCGGCTGGAGCGCGCGCGGGCGGCGGCCGG
GGCCGGCGCGGCCTCGGAGCACCGGCTGCTGCGCTTCTTCAGCGGCATCTTCGCGCGCAGGGACGGGGGCCCGGGCGGCGGGCCCTCGCC
ACGGAGCGGAGCCTCGCGGCCACGCGGCTACTTCAGCCTGCGGCGGGCCCCGGCCGAAGCGCACTCGTCCAGCGCCGAGAGCATCGACGG
CTCCCCGCGCAGAGATGCCTTCGTGAACAGCCAGGAATGGACGCTGAGTCGATCTGTCCCGGAGCTCAAAGTGGGAATTGTGGGTAACTT
GGCCAGCGGCAAGTCTGCCCTGGTGCACCGGTACCTGACGGGCACATATGTCCAGGAGGAGTCTCCGGAAGGTGGCAGGTTCAAGAAAGA
GATTGTCGTTGATGGACAGAGCTATCTGCTGCTGATCAGAGATGAAGGGGGCCCCCCGGAGGCGCAGTTTGCCATGTGGGTGGACGCTGT
TATATTTGTCTTCAGCTTGGAGGATGAAATAAGTTTCCAGACCGTTTACCACTACTACAGTCGAATGGCCAACTATCGGAACACGAGCGA
GATTCCTCTGGTTCTGGTGGGAACCCAGGGGTCCCAGTTCACCAAGTATGGCTGCCGCCGGAGGCTGGACCACAAGATGGTACACCGTGG
CTTCTGTGCCGCCCTCTCGAAGCCCAAAGCCATCCGCAGAGCGTGCAACCCACAGGAATGCTCCCAGCCAGTGTGGGTCACAGGCGAATG
GGAGCCATGTAGCCAGACCTGTGGGCGGACAGGCATGCAGGTGCGCTCCGTGCGCTGCATTCAGCCGCTACACGACAACACCACCCGCTC
CGTGCACGCCAAGCACTGCAATGACGCCCGGCCCGAGAGCCGCCGGGCCTGCAGCCGCGAGCTCTGCCCTGGTCGTTGGCGAGCCGGGCC
CTGGTCCCAGTGCTCAGTAACCTGTGGCAACGGCACCCAGGAGCGGCCAGTGCTCTGCCGCACCGCGGACGACAGCTTCGGCATCTGCCA
GGAGGAGCGTCCTGAGACAGCGAGGACCTGCAGGCTTGGCCCCTGTCCCCGAAACATCTCAGATCCCTCCAAGAAGAGCTACGTAGTTCA
GTGGCTGTCCCGCCCGGACCCCGACTCGCCCATCCGGAAGATCTCGTCAAAGGGCCACTGCCAAGGCGACAAGTCAATATTCTGTAGGAT
GGAAGTCTTGTCCCGCTATTGCTCCATCCCAGGCTACAACAAGCTGTGCTGCAAGTCCTGTAACCTGTACAACAACCTCACCAACGTGGA
GGGCAGGATAGAGCCACCGCCTGGGAAGCACAACGACATTGACGTGTTCATGCCTACCCTCCCAGTGCCCACTGTAGCCATGGAGGTGCG
GCCATCACCAAGCACCCCCCTGGAGGTCCCTCTCAATGCCTCCAGCACCAATGCCACAGAGGATCACCCAGAAACCAATGCCGTAGATGA
ACCCTACAAAATCCATGGCCTGGAAGATGAAGTCCAGCCACCCAACCTAATCCCTCGACGACCGAGCCCCTATGAAAAGACCAGAAACCA
AAGAATCCAAGAGCTCATTGATGAGATGCGGAAGAAAGAGATGCTCGGAAAGTTCTAATAAAATGGAAAGATAGCATCCCTAGCATTTTT
TTCTTGCTTATAGAGATATTCCATGGGATAGCAAATCCTGTGTCATGGAGATGAAGTCAAAATTCCTGATTCCAAAAGGTTTTGAGAAAA
CAAAGAGGGGGAATGACGTAAGAAAGATAGGCATGAGCATGTGGTAACTAGGTTAGCACGTGTGCTTCCCAGCCCAGGAGCGACCAAATA
CTGTGGTGGCGTCAGGTGTGCAGTGGAGAGGAATATAGAGGCTGTATGGCCTCCCTCAGTGAGGGCAGGGCAAGAGGGATCACTCTGAGA
GAACAAAAATAGGCCCCAAGTTGCTAAGCAGTGATTGGGAACCTTCCTTTCCTTGGCGGAGATGCATGACATTCCCTACCGATCCCCAGA
CACAGCCTGTGGGACTCTTAGGAGAAATGGTGATTTACTGAATAACTGACCCGTTGCCGAGATGAGTACAATGAAGTGGAGGTGATGAAC
TCAAATCGTCTTCCAGGGCCAGGCGGCTGACCGGGGTGAGCGTAGTGGCCCGCTGGGGACCATGGCCGCCCTGACAGCCACACCCACCTG
GAGCTGACTTGGTTCTGGCTGTTGCTGCCACTGTGAAATCTGTATCTCTCTCCATCTCTGCTCTACTATCCCCGGCCTTGCCAGACAGTG
TTCTTTTTCGGAAGAAGTCTAGATTTTTGCATGAAAAAAACTCAATCTTTAAAGGTCGACTCAGAACATTTTAAGGAGGCCTCCACTTGG
TCTGATGCAGTCTTGCTAATTAAGAACTAAAGGCCTTCTGACCTTCTTGGTGCTCATGCTGTACGGCATCTGAATGTCTCGACCGAGTCT
GAGCCGTGCAGCTGTCCTCCACCTGCGAAAGTAATGAGAATCCTATCACGGGACATAAGGATAGGTCTAAACAGGGTCCATGCCAAGAAA
ACAGTGGGGTGCTCTCCCAGGCCTCTCCCCTGTCCACTAACCCTGGCCTTGCCGGCTGCCTTCCAGGCTCTGGGGGAAGAGCTCCTGCAT
TCTTCCCTGGCCACCTTGGCTCCAGGGCTCCCCAGAGAGCCTCTTCCCTCCCCAAGTACCTGAGAAAGATGAGAGAGGCACGTGCTCTGC
TGGGAAGGTCCAGTGAGCGGTTCAAGGGCCTGGAATCTCCCTACGGCCAAGTCTAAGGGTTCTGGGATTCTGGGCTTTGTGGGCTTTGCT
TGCTTGCTGGGAATGGGCTTTCCCTGTCCCGCCCTGCCCCACCTCGCCTCTGTCTCTCAGAAGCTCCAGAACCCAGCAGTGACCTGCAAA
ATGTGGCCTCTGATGGGGGCTTAGGGTGGGAGATGGGGAGAGCCTACATTGTCTTTTGCTCCTTGAAAACTTTAATAGCTCCTATTTTCC
AGAGAATGGTGCTTTGTGAGCAACATGCGAGTAAGAGAGAAATAGGAGGAAGGGGGAGTAGGGGCGGATGGGAGAAGAGTGGCTCATTTT
TACCTCTCACTGCCTTGACATTTTGTGAACGTGAAGCTTAAACTTTCTGGGCTTACAAGACCCAGGGGCACGTCAGCTCCTTAGATGGGC
TCAGCCTGACACATAATTCTTAAACCTTTCCTGTTTAAGAAACTTCTAGAGGCTGTGTACTCTCACCAATCCTCTTCGAGAATTTGTTCA
TGTGTATTTCCCCATTATATGGATGAGGCTCAGGATAACAGCATAGTGGCTACCTTCTACTGAGTTTTGAGGTGCTAATAAGTATGTTTG
TCTGAGGCTGCACATGTGGGTGGCTCTGTGTGTATGATCCAAGGGACAAAATGACGATGTAGGAACCAGCAAGAACGGAATCTGGGCTGA
TGCTTCAGTCTCCACCTGGGTGATGGCTAGCCTCCCGCCCTCCACCACCGCATCCCACACGTGCTGCGCACTGTCCCCGTGTCTCCTGGA
GAACCAAACTGGAGAAAACCTTTCTGAGTATCTCTCATAGTACCCCTTCCTTAAGAAGATGTGGTTTAGAGCATGTGTGCAATCCTGCCT
CTGTAATTAGGAAACGGAGCCCGAGGCTTTCCATTGTTGGTTGAACCCAGGACAGCTGGTGCTATTCACAGGCTGAAGAACTGGGCAGTT
CTTACTTGGGTCTGTCCTAGGATGTGGAGGAAGTTCAGGACTAACGCTAGGCAGAGAGTATGACTCGGTTTACCCAGCCTAGGGGCCTCT
GGATGGGAACACTCCATTCCAAGATCTCAGCAGAGCAGGGCTTCCTGGCTTGAGGCTGGAAGCCTTTGGGAAGAGGCCCAGCTGGGACAT
TCCCTGGGCACCTGTCTTCCGCTGAAGGGAGCAAGGTGCCCTCTGGGACTGACAGCCATGACCCTCTGTGCCATCCTCAATCCTTGAGCC
ATATATCAAGAGTCCTCTAGAGCCGGATGGTCCTCAAAAGTCTGTCCAAGGAATGCCAACGTTCACCGGGCTCTGAGAAACGACGCAAAT
CTCTGAGCTGGGGACCACTTGGAGAACCGGCTTAGTAACAGTCCTGATCTTCGCAAGCCAGCTTCTTCTGCATCTGAGGGGCTCCTGGCG
CCCAGAGGAGGCAGACAGATGTCTTCTAGCTGAGTTTCTAACCGCATGATGAGACTCAGACCTTCCGCTGCACTAGAAAATCTGCAACAG
TGTCCCTGAGTCACTTCTCCTTAGTGGGCAGACTCGTGTTAGATTTGTGGAACCCAGCTCTCTGATTTACTCCTTTTGGAAAACCCATGG
AATTTCATGTATAAGGCTTTCATTTGTATTTTAAGGTTTTTCTGTTTGTTTTGAGTATATACATGGTGCTCAATAGCAACATCTTAGCAG
ATGAAGCAGTTTATGATTCCACTCCCTCCTGTATGACAGGTAGCCACTATACTGAATCAAGGTGCTGAACTCAAATCACAAAATTCTGGC
TTACCGATACAACAACCAATACATCTTTGTTCTGTAATGTAAAATTTGACTCCTTACTTTTATAACTTATTAAAGTTAAAATGTCTGTGT

>2759_2759_4_AGAP1-ADAMTS2_AGAP1_chr2_236653483_ENST00000409538_ADAMTS2_chr5_178553131_ENST00000251582_length(amino acids)=809AA_BP=470
MPSPLGPAPSRPAGSLDAAGPQRAGDMYLLDGSGEPASPPADAMPRGTPPRKTVYRISVTMVRKEQLAAPGSGGPDPRPVRRPRPARSPD
APGRLEEEAEEAEGAEEPEGPRPRAWDFRTFRTRSTGQLELGRLRPCARGLEPADLAGSAPAEEEGRGSPASGSPDVEGARAAPLRRSLS
FRHWSGPEAPQGRTLGGGRRHSSSGSLAWAPCDEAAAGTTLEPATATQPASEKRNTLDVGEVLSKNDALSDLERWERSKSKNRTLDNSDL
QRLERARAAAGAGAASEHRLLRFFSGIFARRDGGPGGGPSPRSGASRPRGYFSLRRAPAEAHSSSAESIDGSPRRDAFVNSQEWTLSRSV
PELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYY
SRMANYRNTSEIPLVLVGTQGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRC
IQPLHDNTTRSVHAKHCNDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEERPETARTCRLGPCPRNI
SDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPGYNKLCCKSCNLYNNLTNVEGRIEPPPGKHNDIDVFMPT

--------------------------------------------------------------
>2759_2759_5_AGAP1-ADAMTS2_AGAP1_chr2_236653483_ENST00000428334_ADAMTS2_chr5_178553131_ENST00000251582_length(transcript)=4111nt_BP=76nt
GTTTACCACTACTACAGTCGAATGGCCAACTATCGGAACACGAGCGAGATTCCTCTGGTTCTGGTGGGAACCCAGGGGTCCCAGTTCACC
AAGTATGGCTGCCGCCGGAGGCTGGACCACAAGATGGTACACCGTGGCTTCTGTGCCGCCCTCTCGAAGCCCAAAGCCATCCGCAGAGCG
TGCAACCCACAGGAATGCTCCCAGCCAGTGTGGGTCACAGGCGAATGGGAGCCATGTAGCCAGACCTGTGGGCGGACAGGCATGCAGGTG
CGCTCCGTGCGCTGCATTCAGCCGCTACACGACAACACCACCCGCTCCGTGCACGCCAAGCACTGCAATGACGCCCGGCCCGAGAGCCGC
CGGGCCTGCAGCCGCGAGCTCTGCCCTGGTCGTTGGCGAGCCGGGCCCTGGTCCCAGTGCTCAGTAACCTGTGGCAACGGCACCCAGGAG
CGGCCAGTGCTCTGCCGCACCGCGGACGACAGCTTCGGCATCTGCCAGGAGGAGCGTCCTGAGACAGCGAGGACCTGCAGGCTTGGCCCC
TGTCCCCGAAACATCTCAGATCCCTCCAAGAAGAGCTACGTAGTTCAGTGGCTGTCCCGCCCGGACCCCGACTCGCCCATCCGGAAGATC
TCGTCAAAGGGCCACTGCCAAGGCGACAAGTCAATATTCTGTAGGATGGAAGTCTTGTCCCGCTATTGCTCCATCCCAGGCTACAACAAG
CTGTGCTGCAAGTCCTGTAACCTGTACAACAACCTCACCAACGTGGAGGGCAGGATAGAGCCACCGCCTGGGAAGCACAACGACATTGAC
GTGTTCATGCCTACCCTCCCAGTGCCCACTGTAGCCATGGAGGTGCGGCCATCACCAAGCACCCCCCTGGAGGTCCCTCTCAATGCCTCC
AGCACCAATGCCACAGAGGATCACCCAGAAACCAATGCCGTAGATGAACCCTACAAAATCCATGGCCTGGAAGATGAAGTCCAGCCACCC
AACCTAATCCCTCGACGACCGAGCCCCTATGAAAAGACCAGAAACCAAAGAATCCAAGAGCTCATTGATGAGATGCGGAAGAAAGAGATG
CTCGGAAAGTTCTAATAAAATGGAAAGATAGCATCCCTAGCATTTTTTTCTTGCTTATAGAGATATTCCATGGGATAGCAAATCCTGTGT
CATGGAGATGAAGTCAAAATTCCTGATTCCAAAAGGTTTTGAGAAAACAAAGAGGGGGAATGACGTAAGAAAGATAGGCATGAGCATGTG
GTAACTAGGTTAGCACGTGTGCTTCCCAGCCCAGGAGCGACCAAATACTGTGGTGGCGTCAGGTGTGCAGTGGAGAGGAATATAGAGGCT
GTATGGCCTCCCTCAGTGAGGGCAGGGCAAGAGGGATCACTCTGAGAGAACAAAAATAGGCCCCAAGTTGCTAAGCAGTGATTGGGAACC
TTCCTTTCCTTGGCGGAGATGCATGACATTCCCTACCGATCCCCAGACACAGCCTGTGGGACTCTTAGGAGAAATGGTGATTTACTGAAT
AACTGACCCGTTGCCGAGATGAGTACAATGAAGTGGAGGTGATGAACTCAAATCGTCTTCCAGGGCCAGGCGGCTGACCGGGGTGAGCGT
AGTGGCCCGCTGGGGACCATGGCCGCCCTGACAGCCACACCCACCTGGAGCTGACTTGGTTCTGGCTGTTGCTGCCACTGTGAAATCTGT
ATCTCTCTCCATCTCTGCTCTACTATCCCCGGCCTTGCCAGACAGTGTTCTTTTTCGGAAGAAGTCTAGATTTTTGCATGAAAAAAACTC
AATCTTTAAAGGTCGACTCAGAACATTTTAAGGAGGCCTCCACTTGGTCTGATGCAGTCTTGCTAATTAAGAACTAAAGGCCTTCTGACC
TTCTTGGTGCTCATGCTGTACGGCATCTGAATGTCTCGACCGAGTCTGAGCCGTGCAGCTGTCCTCCACCTGCGAAAGTAATGAGAATCC
TATCACGGGACATAAGGATAGGTCTAAACAGGGTCCATGCCAAGAAAACAGTGGGGTGCTCTCCCAGGCCTCTCCCCTGTCCACTAACCC
TGGCCTTGCCGGCTGCCTTCCAGGCTCTGGGGGAAGAGCTCCTGCATTCTTCCCTGGCCACCTTGGCTCCAGGGCTCCCCAGAGAGCCTC
TTCCCTCCCCAAGTACCTGAGAAAGATGAGAGAGGCACGTGCTCTGCTGGGAAGGTCCAGTGAGCGGTTCAAGGGCCTGGAATCTCCCTA
CGGCCAAGTCTAAGGGTTCTGGGATTCTGGGCTTTGTGGGCTTTGCTTGCTTGCTGGGAATGGGCTTTCCCTGTCCCGCCCTGCCCCACC
TCGCCTCTGTCTCTCAGAAGCTCCAGAACCCAGCAGTGACCTGCAAAATGTGGCCTCTGATGGGGGCTTAGGGTGGGAGATGGGGAGAGC
CTACATTGTCTTTTGCTCCTTGAAAACTTTAATAGCTCCTATTTTCCAGAGAATGGTGCTTTGTGAGCAACATGCGAGTAAGAGAGAAAT
AGGAGGAAGGGGGAGTAGGGGCGGATGGGAGAAGAGTGGCTCATTTTTACCTCTCACTGCCTTGACATTTTGTGAACGTGAAGCTTAAAC
TTTCTGGGCTTACAAGACCCAGGGGCACGTCAGCTCCTTAGATGGGCTCAGCCTGACACATAATTCTTAAACCTTTCCTGTTTAAGAAAC
TTCTAGAGGCTGTGTACTCTCACCAATCCTCTTCGAGAATTTGTTCATGTGTATTTCCCCATTATATGGATGAGGCTCAGGATAACAGCA
TAGTGGCTACCTTCTACTGAGTTTTGAGGTGCTAATAAGTATGTTTGTCTGAGGCTGCACATGTGGGTGGCTCTGTGTGTATGATCCAAG
GGACAAAATGACGATGTAGGAACCAGCAAGAACGGAATCTGGGCTGATGCTTCAGTCTCCACCTGGGTGATGGCTAGCCTCCCGCCCTCC
ACCACCGCATCCCACACGTGCTGCGCACTGTCCCCGTGTCTCCTGGAGAACCAAACTGGAGAAAACCTTTCTGAGTATCTCTCATAGTAC
CCCTTCCTTAAGAAGATGTGGTTTAGAGCATGTGTGCAATCCTGCCTCTGTAATTAGGAAACGGAGCCCGAGGCTTTCCATTGTTGGTTG
AACCCAGGACAGCTGGTGCTATTCACAGGCTGAAGAACTGGGCAGTTCTTACTTGGGTCTGTCCTAGGATGTGGAGGAAGTTCAGGACTA
ACGCTAGGCAGAGAGTATGACTCGGTTTACCCAGCCTAGGGGCCTCTGGATGGGAACACTCCATTCCAAGATCTCAGCAGAGCAGGGCTT
CCTGGCTTGAGGCTGGAAGCCTTTGGGAAGAGGCCCAGCTGGGACATTCCCTGGGCACCTGTCTTCCGCTGAAGGGAGCAAGGTGCCCTC
TGGGACTGACAGCCATGACCCTCTGTGCCATCCTCAATCCTTGAGCCATATATCAAGAGTCCTCTAGAGCCGGATGGTCCTCAAAAGTCT
GTCCAAGGAATGCCAACGTTCACCGGGCTCTGAGAAACGACGCAAATCTCTGAGCTGGGGACCACTTGGAGAACCGGCTTAGTAACAGTC
CTGATCTTCGCAAGCCAGCTTCTTCTGCATCTGAGGGGCTCCTGGCGCCCAGAGGAGGCAGACAGATGTCTTCTAGCTGAGTTTCTAACC
GCATGATGAGACTCAGACCTTCCGCTGCACTAGAAAATCTGCAACAGTGTCCCTGAGTCACTTCTCCTTAGTGGGCAGACTCGTGTTAGA
TTTGTGGAACCCAGCTCTCTGATTTACTCCTTTTGGAAAACCCATGGAATTTCATGTATAAGGCTTTCATTTGTATTTTAAGGTTTTTCT
GTTTGTTTTGAGTATATACATGGTGCTCAATAGCAACATCTTAGCAGATGAAGCAGTTTATGATTCCACTCCCTCCTGTATGACAGGTAG
CCACTATACTGAATCAAGGTGCTGAACTCAAATCACAAAATTCTGGCTTACCGATACAACAACCAATACATCTTTGTTCTGTAATGTAAA

>2759_2759_5_AGAP1-ADAMTS2_AGAP1_chr2_236653483_ENST00000428334_ADAMTS2_chr5_178553131_ENST00000251582_length(amino acids)=357AA_BP=18
MANYRNTSEIPLVLVGTQGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQ
PLHDNTTRSVHAKHCNDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEERPETARTCRLGPCPRNISD
PSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPGYNKLCCKSCNLYNNLTNVEGRIEPPPGKHNDIDVFMPTLP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AGAP1-ADAMTS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AGAP1-ADAMTS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AGAP1-ADAMTS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAGAP1C0004352Autistic Disorder1CTD_human
TgeneC2700425EHLERS-DANLOS SYNDROME, DERMATOSPARAXIS TYPE2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0345967Malignant mesothelioma1CTD_human