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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AP1S1-PTOV1 (FusionGDB2 ID:HG1174TG53635)

Fusion Gene Summary for AP1S1-PTOV1

check button Fusion gene summary
Fusion gene informationFusion gene name: AP1S1-PTOV1
Fusion gene ID: hg1174tg53635
HgeneTgene
Gene symbol

AP1S1

PTOV1

Gene ID

1174

53635

Gene nameadaptor related protein complex 1 subunit sigma 1PTOV1 extended AT-hook containing adaptor protein
SynonymsAP19|CLAPS1|EKV3|MEDNIK|SIGMA1AACID2|PTOV-1
Cytomap('AP1S1')('PTOV1')

7q22.1

19q13.33

Type of geneprotein-codingprotein-coding
DescriptionAP-1 complex subunit sigma-1AHA1 19 kDa subunitadapter-related protein complex 1 sigma-1A subunitadaptor protein complex AP-1 subunit sigma-1Aadaptor related protein complex 1 sigma 1 subunitadaptor-related protein complex 1 subunit sigma-1Aclathrinprostate tumor-overexpressed gene 1 proteinactivator interaction domain-containing protein 2prostate tumor overexpressed 1
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000337619, 
Fusion gene scores* DoF score3 X 3 X 3=278 X 8 X 5=320
# samples 410
** MAII scorelog2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/320*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AP1S1 [Title/Abstract] AND PTOV1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAP1S1(100797798)-PTOV1(50357663), # samples:3
Anticipated loss of major functional domain due to fusion event.AP1S1-PTOV1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AP1S1-PTOV1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across AP1S1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PTOV1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N8-A56S-01AAP1S1chr7

100797798

-PTOV1chr19

50357663

+
ChimerDB4UCSTCGA-N8-A56S-01AAP1S1chr7

100797798

+PTOV1chr19

50357663

+
ChimerDB4UCSTCGA-N8-A56SAP1S1chr7

100797798

+PTOV1chr19

50357662

+
ChimerDB4UCSTCGA-N8-A56SAP1S1chr7

100797798

+PTOV1chr19

50357663

+


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Fusion Gene ORF analysis for AP1S1-PTOV1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000337619ENST00000391842AP1S1chr7

100797798

+PTOV1chr19

50357663

+
5CDS-3UTRENST00000337619ENST00000391842AP1S1chr7

100797798

+PTOV1chr19

50357662

+
5CDS-3UTRENST00000337619ENST00000598325AP1S1chr7

100797798

+PTOV1chr19

50357663

+
5CDS-3UTRENST00000337619ENST00000598325AP1S1chr7

100797798

+PTOV1chr19

50357662

+
5CDS-3UTRENST00000337619ENST00000599732AP1S1chr7

100797798

+PTOV1chr19

50357663

+
5CDS-3UTRENST00000337619ENST00000599732AP1S1chr7

100797798

+PTOV1chr19

50357662

+
5CDS-3UTRENST00000337619ENST00000601675AP1S1chr7

100797798

+PTOV1chr19

50357663

+
5CDS-3UTRENST00000337619ENST00000601675AP1S1chr7

100797798

+PTOV1chr19

50357662

+
In-frameENST00000337619ENST00000221557AP1S1chr7

100797798

+PTOV1chr19

50357663

+
In-frameENST00000337619ENST00000221557AP1S1chr7

100797798

+PTOV1chr19

50357662

+
In-frameENST00000337619ENST00000600603AP1S1chr7

100797798

+PTOV1chr19

50357663

+
In-frameENST00000337619ENST00000600603AP1S1chr7

100797798

+PTOV1chr19

50357662

+
In-frameENST00000337619ENST00000601638AP1S1chr7

100797798

+PTOV1chr19

50357663

+
In-frameENST00000337619ENST00000601638AP1S1chr7

100797798

+PTOV1chr19

50357662

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000337619AP1S1chr7100797798+ENST00000600603PTOV1chr1950357663+13621211181170350
ENST00000337619AP1S1chr7100797798+ENST00000601638PTOV1chr1950357663+14061211181200360
ENST00000337619AP1S1chr7100797798+ENST00000221557PTOV1chr1950357663+15851211181170350
ENST00000337619AP1S1chr7100797798+ENST00000600603PTOV1chr1950357662+13621211181170350
ENST00000337619AP1S1chr7100797798+ENST00000601638PTOV1chr1950357662+14061211181200360
ENST00000337619AP1S1chr7100797798+ENST00000221557PTOV1chr1950357662+15851211181170350

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000337619ENST00000600603AP1S1chr7100797798+PTOV1chr1950357663+0.192973020.807027
ENST00000337619ENST00000601638AP1S1chr7100797798+PTOV1chr1950357663+0.099987790.9000122
ENST00000337619ENST00000221557AP1S1chr7100797798+PTOV1chr1950357663+0.208147570.7918524
ENST00000337619ENST00000600603AP1S1chr7100797798+PTOV1chr1950357662+0.192973020.807027
ENST00000337619ENST00000601638AP1S1chr7100797798+PTOV1chr1950357662+0.099987790.9000122
ENST00000337619ENST00000221557AP1S1chr7100797798+PTOV1chr1950357662+0.208147570.7918524

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Fusion Genomic Features for AP1S1-PTOV1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AP1S1chr7100797798+PTOV1chr1950357662+7.76E-050.9999224
AP1S1chr7100797798+PTOV1chr1950357662+7.76E-050.9999224
AP1S1chr7100797798+PTOV1chr1950357662+7.76E-050.9999224
AP1S1chr7100797798+PTOV1chr1950357662+7.76E-050.9999224

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AP1S1-PTOV1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:100797798/chr19:50357663)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for AP1S1-PTOV1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5205_5205_1_AP1S1-PTOV1_AP1S1_chr7_100797798_ENST00000337619_PTOV1_chr19_50357662_ENST00000221557_length(transcript)=1585nt_BP=121nt
GGCGGGACGGGGCGGGGCTTCGGGCGAGAGGGAGGGCAGCAGGAGAAAGGATAAGAAAGGGAGTGGGACTGGCGCCTACGGTGGCCGAAG
TGGGACGCGCCGAGCCGGAGGCTGCAGGATGGAAGGTGCTCGGGTCTTCGGGGCACTGGGTCCCATCGGTCCCTCCTCACCTGGGCTCAC
CCTCGGGGGTCTGGCCGTGAGCGAGCACCGGCTCAGCAACAAGCTGCTGGCTTGGAGCGGCGTCCTCGAGTGGCAGGAGAAGCGCAGACC
CTACTCTGACTCCACTGCAAAGCTGAAGCGGACCCTGCCCTGCCAAGCCTACGTGAACCAAGGCGAGAACCTGGAGACCGACCAGTGGCC
GCAGAAGCTGATCATGCAGCTGATCCCTCAGCAGCTGCTGACCACCCTGGGCCCCCTGTTCCGGAACTCCCAGTTGGCACAGTTCCACTT
CACCAACAGAGACTGCGACTCGCTCAAGGGGCTCTGCCGCATCATGGGCAACGGCTTCGCGGGCTGCATGCTGTTCCCCCACATCTCCCC
CTGTGAGGTGCGCGTGCTCATGCTCCTGTACTCGTCCAAGAAGAAGATCTTCATGGGCCTCATCCCCTACGACCAGAGCGGCTTCGTCAG
TGCCATCCGGCAGGTCATCACCACCCGCAAGCAGGCAGTGGGACCTGGTGGTGTCAACTCAGGCCCAGTCCAGATCGTCAACAACAAGTT
TCTGGCATGGAGTGGTGTCATGGAGTGGCAGGAGCCCAGGCCTGAGCCCAACAGTCGGTCCAAGAGGTGGCTGCCATCCCACGTCTACGT
GAACCAGGGGGAGATCCTGAGGACCGAGCAGTGGCCAAGGAAGCTGTACATGCAGCTCATCCCGCAGCAGCTGCTGACCACCCTAGTGCC
GCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACACTGAAGAGCCTGTGCCGGATCATGGACAATGGCTT
CAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACGGCATCCGGCGTGTCATTGCCAACCAGCAGCAGGTC
CTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGTTACCCCGGGCTGGGCCCCTCCAGGAGTCACAGATG
AGGCCCCCGCAGAGACTGGTGAGTGGTGACCCTGTCATGTACAGGAGGGACCCTGGGGCATGTGGGGGGGGTGGGGTTGGGAAAGAAGCA
GGGCGACCTTGGCCTTGGGGAGAGCAGAGCAGAGGGAGAGGCAGCAGTCCCAGCGGTCCTAGGCTGTCGGGAAACTGCAGCCCAGCCTCA
GGGCCATGGGAGGTGGTATCCAGGCCTGGGTGGGGCCAGGCCTCTGCTCACAGGGATGTGGGGTCAGTGCTTGGGAGCCTGTGGCCAGCA
GCCCCCACTGCACCCCTGCCCCCAGGTGACACGCTTCTGAGCAGGGGCCCCTGGGGACTTCAACTGCCCAGCAACATGGAGGATGGTGTC

>5205_5205_1_AP1S1-PTOV1_AP1S1_chr7_100797798_ENST00000337619_PTOV1_chr19_50357662_ENST00000221557_length(amino acids)=350AA_BP=32
MEGARVFGALGPIGPSSPGLTLGGLAVSEHRLSNKLLAWSGVLEWQEKRRPYSDSTAKLKRTLPCQAYVNQGENLETDQWPQKLIMQLIP
QQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCRIMGNGFAGCMLFPHISPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVSAIRQVITTR
KQAVGPGGVNSGPVQIVNNKFLAWSGVMEWQEPRPEPNSRSKRWLPSHVYVNQGEILRTEQWPRKLYMQLIPQQLLTTLVPLFRNSRLVQ

--------------------------------------------------------------
>5205_5205_2_AP1S1-PTOV1_AP1S1_chr7_100797798_ENST00000337619_PTOV1_chr19_50357662_ENST00000600603_length(transcript)=1362nt_BP=121nt
GGCGGGACGGGGCGGGGCTTCGGGCGAGAGGGAGGGCAGCAGGAGAAAGGATAAGAAAGGGAGTGGGACTGGCGCCTACGGTGGCCGAAG
TGGGACGCGCCGAGCCGGAGGCTGCAGGATGGAAGGTGCTCGGGTCTTCGGGGCACTGGGTCCCATCGGTCCCTCCTCACCTGGGCTCAC
CCTCGGGGGTCTGGCCGTGAGCGAGCACCGGCTCAGCAACAAGCTGCTGGCTTGGAGCGGCGTCCTCGAGTGGCAGGAGAAGCGCAGACC
CTACTCTGACTCCACTGCAAAGCTGAAGCGGACCCTGCCCTGCCAAGCCTACGTGAACCAAGGCGAGAACCTGGAGACCGACCAGTGGCC
GCAGAAGCTGATCATGCAGCTGATCCCTCAGCAGCTGCTGACCACCCTGGGCCCCCTGTTCCGGAACTCCCAGTTGGCACAGTTCCACTT
CACCAACAGAGACTGCGACTCGCTCAAGGGGCTCTGCCGCATCATGGGCAACGGCTTCGCGGGCTGCATGCTGTTCCCCCACATCTCCCC
CTGTGAGGTGCGCGTGCTCATGCTCCTGTACTCGTCCAAGAAGAAGATCTTCATGGGCCTCATCCCCTACGACCAGAGCGGCTTCGTCAG
TGCCATCCGGCAGGTCATCACCACCCGCAAGCAGGCAGTGGGACCTGGTGGTGTCAACTCAGGCCCAGTCCAGATCGTCAACAACAAGTT
TCTGGCATGGAGTGGTGTCATGGAGTGGCAGGAGCCCAGGCCTGAGCCCAACAGTCGGTCCAAGAGGTGGCTGCCATCCCACGTCTACGT
GAACCAGGGGGAGATCCTGAGGACCGAGCAGTGGCCAAGGAAGCTGTACATGCAGCTCATCCCGCAGCAGCTGCTGACCACCCTAGTGCC
GCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACACTGAAGAGCCTGTGCCGGATCATGGACAATGGCTT
CAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACGGCATCCGGCGTGTCATTGCCAACCAGCAGCAGGTC
CTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGTTACCCCGGGCTGGGCCCCTCCAGGAGTCACAGATG
AGGCCCCCGCAGAGACTGTGCTTGGGAGCCTGTGGCCAGCAGCCCCCACTGCACCCCTGCCCCCAGGTGACACGCTTCTGAGCAGGGGCC
CCTGGGGACTTCAACTGCCCAGCAACATGGAGGATGGTGTCCTGAGGCCTCCAAGGACGGTCCCCACCCCTCTACGTTTCCCCAATAAAG

>5205_5205_2_AP1S1-PTOV1_AP1S1_chr7_100797798_ENST00000337619_PTOV1_chr19_50357662_ENST00000600603_length(amino acids)=350AA_BP=32
MEGARVFGALGPIGPSSPGLTLGGLAVSEHRLSNKLLAWSGVLEWQEKRRPYSDSTAKLKRTLPCQAYVNQGENLETDQWPQKLIMQLIP
QQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCRIMGNGFAGCMLFPHISPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVSAIRQVITTR
KQAVGPGGVNSGPVQIVNNKFLAWSGVMEWQEPRPEPNSRSKRWLPSHVYVNQGEILRTEQWPRKLYMQLIPQQLLTTLVPLFRNSRLVQ

--------------------------------------------------------------
>5205_5205_3_AP1S1-PTOV1_AP1S1_chr7_100797798_ENST00000337619_PTOV1_chr19_50357662_ENST00000601638_length(transcript)=1406nt_BP=121nt
GGCGGGACGGGGCGGGGCTTCGGGCGAGAGGGAGGGCAGCAGGAGAAAGGATAAGAAAGGGAGTGGGACTGGCGCCTACGGTGGCCGAAG
TGGGACGCGCCGAGCCGGAGGCTGCAGGATGGAAGGTGCTCGGGTCTTCGGGGCACTGGGTCCCATCGGTCCCTCCTCACCTGGGCTCAC
CCTCGGGGGTCTGGCCGTGAGCGAGCACCGGCTCAGCAACAAGCTGCTGGCTTGGAGCGGCGTCCTCGAGTGGCAGGAGAAGCGCAGACC
CTACTCTGACTCCACTGCAAAGCTGAAGCGGACCCTGCCCTGCCAAGCCTACGTGAACCAAGGCGAGAACCTGGAGACCGACCAGTGGCC
GCAGAAGCTGATCATGCAGCTGATCCCTCAGCAGCTGCTGACCACCCTGGGCCCCCTGTTCCGGAACTCCCAGTTGGCACAGTTCCACTT
CACCAACAGAGACTGCGACTCGCTCAAGGGGCTCTGCCGCATCATGGGCAACGGCTTCGCGGGCTGCATGCTGTTCCCCCACATCTCCCC
CTGTGAGGTGCGCGTGCTCATGCTCCTGTACTCGTCCAAGAAGAAGATCTTCATGGGCCTCATCCCCTACGACCAGAGCGGCTTCGTCAG
TGCCATCCGGCAGGTCATCACCACCCGCAAGCAGGCAGTGGGACCTGGTGGTGTCAACTCAGGCCCAGTCCAGATCGTCAACAACAAGTT
TCTGGCATGGAGTGGTGTCATGGAGTGGCAGGAGCCCAGGCCTGAGCCCAACAGTCGGTCCAAGAGGTGGCTGCCATCCCACGTCTACGT
GAACCAGGGGGAGATCCTGAGGACCGAGCAGTGGCCAAGGAAGCTGTACATGCAGCTCATCCCGCAGCAGCTGCTGACCACCCTAGTGCC
GCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACACTGAAGAGCCTGTGCCGGATCATGGACAATGGCTT
CGCCGGCTGCGTGCACTTTTCCTACAAAGCATCGTGTGAGATCCGCGTGCTTATGCTCCTGTACTCTTCAGAGAAGAAAATCTTCATTGG
CCTCATCCCCCATGACCAGGGCAACTTTGTCAACGGCATCCGGCGTGTCATTGCCAACCAGCAGCAGGTCCTGCAGCGGAACCTGGAGCA
GGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGTTACCCCGGGCTGGGCCCCTCCAGGAGTCACAGATGAGGCCCCCGCAGAGACTGTG
CTTGGGAGCCTGTGGCCAGCAGCCCCCACTGCACCCCTGCCCCCAGGTGACACGCTTCTGAGCAGGGGCCCCTGGGGACTTCAACTGCCC

>5205_5205_3_AP1S1-PTOV1_AP1S1_chr7_100797798_ENST00000337619_PTOV1_chr19_50357662_ENST00000601638_length(amino acids)=360AA_BP=32
MEGARVFGALGPIGPSSPGLTLGGLAVSEHRLSNKLLAWSGVLEWQEKRRPYSDSTAKLKRTLPCQAYVNQGENLETDQWPQKLIMQLIP
QQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCRIMGNGFAGCMLFPHISPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVSAIRQVITTR
KQAVGPGGVNSGPVQIVNNKFLAWSGVMEWQEPRPEPNSRSKRWLPSHVYVNQGEILRTEQWPRKLYMQLIPQQLLTTLVPLFRNSRLVQ
FHFTKDLETLKSLCRIMDNGFAGCVHFSYKASCEIRVLMLLYSSEKKIFIGLIPHDQGNFVNGIRRVIANQQQVLQRNLEQEQQQRGMGG

--------------------------------------------------------------
>5205_5205_4_AP1S1-PTOV1_AP1S1_chr7_100797798_ENST00000337619_PTOV1_chr19_50357663_ENST00000221557_length(transcript)=1585nt_BP=121nt
GGCGGGACGGGGCGGGGCTTCGGGCGAGAGGGAGGGCAGCAGGAGAAAGGATAAGAAAGGGAGTGGGACTGGCGCCTACGGTGGCCGAAG
TGGGACGCGCCGAGCCGGAGGCTGCAGGATGGAAGGTGCTCGGGTCTTCGGGGCACTGGGTCCCATCGGTCCCTCCTCACCTGGGCTCAC
CCTCGGGGGTCTGGCCGTGAGCGAGCACCGGCTCAGCAACAAGCTGCTGGCTTGGAGCGGCGTCCTCGAGTGGCAGGAGAAGCGCAGACC
CTACTCTGACTCCACTGCAAAGCTGAAGCGGACCCTGCCCTGCCAAGCCTACGTGAACCAAGGCGAGAACCTGGAGACCGACCAGTGGCC
GCAGAAGCTGATCATGCAGCTGATCCCTCAGCAGCTGCTGACCACCCTGGGCCCCCTGTTCCGGAACTCCCAGTTGGCACAGTTCCACTT
CACCAACAGAGACTGCGACTCGCTCAAGGGGCTCTGCCGCATCATGGGCAACGGCTTCGCGGGCTGCATGCTGTTCCCCCACATCTCCCC
CTGTGAGGTGCGCGTGCTCATGCTCCTGTACTCGTCCAAGAAGAAGATCTTCATGGGCCTCATCCCCTACGACCAGAGCGGCTTCGTCAG
TGCCATCCGGCAGGTCATCACCACCCGCAAGCAGGCAGTGGGACCTGGTGGTGTCAACTCAGGCCCAGTCCAGATCGTCAACAACAAGTT
TCTGGCATGGAGTGGTGTCATGGAGTGGCAGGAGCCCAGGCCTGAGCCCAACAGTCGGTCCAAGAGGTGGCTGCCATCCCACGTCTACGT
GAACCAGGGGGAGATCCTGAGGACCGAGCAGTGGCCAAGGAAGCTGTACATGCAGCTCATCCCGCAGCAGCTGCTGACCACCCTAGTGCC
GCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACACTGAAGAGCCTGTGCCGGATCATGGACAATGGCTT
CAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACGGCATCCGGCGTGTCATTGCCAACCAGCAGCAGGTC
CTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGTTACCCCGGGCTGGGCCCCTCCAGGAGTCACAGATG
AGGCCCCCGCAGAGACTGGTGAGTGGTGACCCTGTCATGTACAGGAGGGACCCTGGGGCATGTGGGGGGGGTGGGGTTGGGAAAGAAGCA
GGGCGACCTTGGCCTTGGGGAGAGCAGAGCAGAGGGAGAGGCAGCAGTCCCAGCGGTCCTAGGCTGTCGGGAAACTGCAGCCCAGCCTCA
GGGCCATGGGAGGTGGTATCCAGGCCTGGGTGGGGCCAGGCCTCTGCTCACAGGGATGTGGGGTCAGTGCTTGGGAGCCTGTGGCCAGCA
GCCCCCACTGCACCCCTGCCCCCAGGTGACACGCTTCTGAGCAGGGGCCCCTGGGGACTTCAACTGCCCAGCAACATGGAGGATGGTGTC

>5205_5205_4_AP1S1-PTOV1_AP1S1_chr7_100797798_ENST00000337619_PTOV1_chr19_50357663_ENST00000221557_length(amino acids)=350AA_BP=32
MEGARVFGALGPIGPSSPGLTLGGLAVSEHRLSNKLLAWSGVLEWQEKRRPYSDSTAKLKRTLPCQAYVNQGENLETDQWPQKLIMQLIP
QQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCRIMGNGFAGCMLFPHISPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVSAIRQVITTR
KQAVGPGGVNSGPVQIVNNKFLAWSGVMEWQEPRPEPNSRSKRWLPSHVYVNQGEILRTEQWPRKLYMQLIPQQLLTTLVPLFRNSRLVQ

--------------------------------------------------------------
>5205_5205_5_AP1S1-PTOV1_AP1S1_chr7_100797798_ENST00000337619_PTOV1_chr19_50357663_ENST00000600603_length(transcript)=1362nt_BP=121nt
GGCGGGACGGGGCGGGGCTTCGGGCGAGAGGGAGGGCAGCAGGAGAAAGGATAAGAAAGGGAGTGGGACTGGCGCCTACGGTGGCCGAAG
TGGGACGCGCCGAGCCGGAGGCTGCAGGATGGAAGGTGCTCGGGTCTTCGGGGCACTGGGTCCCATCGGTCCCTCCTCACCTGGGCTCAC
CCTCGGGGGTCTGGCCGTGAGCGAGCACCGGCTCAGCAACAAGCTGCTGGCTTGGAGCGGCGTCCTCGAGTGGCAGGAGAAGCGCAGACC
CTACTCTGACTCCACTGCAAAGCTGAAGCGGACCCTGCCCTGCCAAGCCTACGTGAACCAAGGCGAGAACCTGGAGACCGACCAGTGGCC
GCAGAAGCTGATCATGCAGCTGATCCCTCAGCAGCTGCTGACCACCCTGGGCCCCCTGTTCCGGAACTCCCAGTTGGCACAGTTCCACTT
CACCAACAGAGACTGCGACTCGCTCAAGGGGCTCTGCCGCATCATGGGCAACGGCTTCGCGGGCTGCATGCTGTTCCCCCACATCTCCCC
CTGTGAGGTGCGCGTGCTCATGCTCCTGTACTCGTCCAAGAAGAAGATCTTCATGGGCCTCATCCCCTACGACCAGAGCGGCTTCGTCAG
TGCCATCCGGCAGGTCATCACCACCCGCAAGCAGGCAGTGGGACCTGGTGGTGTCAACTCAGGCCCAGTCCAGATCGTCAACAACAAGTT
TCTGGCATGGAGTGGTGTCATGGAGTGGCAGGAGCCCAGGCCTGAGCCCAACAGTCGGTCCAAGAGGTGGCTGCCATCCCACGTCTACGT
GAACCAGGGGGAGATCCTGAGGACCGAGCAGTGGCCAAGGAAGCTGTACATGCAGCTCATCCCGCAGCAGCTGCTGACCACCCTAGTGCC
GCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACACTGAAGAGCCTGTGCCGGATCATGGACAATGGCTT
CAGAAGAAAATCTTCATTGGCCTCATCCCCCATGACCAGGGCAACTTTGTCAACGGCATCCGGCGTGTCATTGCCAACCAGCAGCAGGTC
CTGCAGCGGAACCTGGAGCAGGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGTTACCCCGGGCTGGGCCCCTCCAGGAGTCACAGATG
AGGCCCCCGCAGAGACTGTGCTTGGGAGCCTGTGGCCAGCAGCCCCCACTGCACCCCTGCCCCCAGGTGACACGCTTCTGAGCAGGGGCC
CCTGGGGACTTCAACTGCCCAGCAACATGGAGGATGGTGTCCTGAGGCCTCCAAGGACGGTCCCCACCCCTCTACGTTTCCCCAATAAAG

>5205_5205_5_AP1S1-PTOV1_AP1S1_chr7_100797798_ENST00000337619_PTOV1_chr19_50357663_ENST00000600603_length(amino acids)=350AA_BP=32
MEGARVFGALGPIGPSSPGLTLGGLAVSEHRLSNKLLAWSGVLEWQEKRRPYSDSTAKLKRTLPCQAYVNQGENLETDQWPQKLIMQLIP
QQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCRIMGNGFAGCMLFPHISPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVSAIRQVITTR
KQAVGPGGVNSGPVQIVNNKFLAWSGVMEWQEPRPEPNSRSKRWLPSHVYVNQGEILRTEQWPRKLYMQLIPQQLLTTLVPLFRNSRLVQ

--------------------------------------------------------------
>5205_5205_6_AP1S1-PTOV1_AP1S1_chr7_100797798_ENST00000337619_PTOV1_chr19_50357663_ENST00000601638_length(transcript)=1406nt_BP=121nt
GGCGGGACGGGGCGGGGCTTCGGGCGAGAGGGAGGGCAGCAGGAGAAAGGATAAGAAAGGGAGTGGGACTGGCGCCTACGGTGGCCGAAG
TGGGACGCGCCGAGCCGGAGGCTGCAGGATGGAAGGTGCTCGGGTCTTCGGGGCACTGGGTCCCATCGGTCCCTCCTCACCTGGGCTCAC
CCTCGGGGGTCTGGCCGTGAGCGAGCACCGGCTCAGCAACAAGCTGCTGGCTTGGAGCGGCGTCCTCGAGTGGCAGGAGAAGCGCAGACC
CTACTCTGACTCCACTGCAAAGCTGAAGCGGACCCTGCCCTGCCAAGCCTACGTGAACCAAGGCGAGAACCTGGAGACCGACCAGTGGCC
GCAGAAGCTGATCATGCAGCTGATCCCTCAGCAGCTGCTGACCACCCTGGGCCCCCTGTTCCGGAACTCCCAGTTGGCACAGTTCCACTT
CACCAACAGAGACTGCGACTCGCTCAAGGGGCTCTGCCGCATCATGGGCAACGGCTTCGCGGGCTGCATGCTGTTCCCCCACATCTCCCC
CTGTGAGGTGCGCGTGCTCATGCTCCTGTACTCGTCCAAGAAGAAGATCTTCATGGGCCTCATCCCCTACGACCAGAGCGGCTTCGTCAG
TGCCATCCGGCAGGTCATCACCACCCGCAAGCAGGCAGTGGGACCTGGTGGTGTCAACTCAGGCCCAGTCCAGATCGTCAACAACAAGTT
TCTGGCATGGAGTGGTGTCATGGAGTGGCAGGAGCCCAGGCCTGAGCCCAACAGTCGGTCCAAGAGGTGGCTGCCATCCCACGTCTACGT
GAACCAGGGGGAGATCCTGAGGACCGAGCAGTGGCCAAGGAAGCTGTACATGCAGCTCATCCCGCAGCAGCTGCTGACCACCCTAGTGCC
GCTGTTCCGGAACTCGCGCCTGGTCCAGTTCCACTTCACCAAGGACCTGGAGACACTGAAGAGCCTGTGCCGGATCATGGACAATGGCTT
CGCCGGCTGCGTGCACTTTTCCTACAAAGCATCGTGTGAGATCCGCGTGCTTATGCTCCTGTACTCTTCAGAGAAGAAAATCTTCATTGG
CCTCATCCCCCATGACCAGGGCAACTTTGTCAACGGCATCCGGCGTGTCATTGCCAACCAGCAGCAGGTCCTGCAGCGGAACCTGGAGCA
GGAGCAACAGCAACGAGGGATGGGGGGGTAGTGGTTACCCCGGGCTGGGCCCCTCCAGGAGTCACAGATGAGGCCCCCGCAGAGACTGTG
CTTGGGAGCCTGTGGCCAGCAGCCCCCACTGCACCCCTGCCCCCAGGTGACACGCTTCTGAGCAGGGGCCCCTGGGGACTTCAACTGCCC

>5205_5205_6_AP1S1-PTOV1_AP1S1_chr7_100797798_ENST00000337619_PTOV1_chr19_50357663_ENST00000601638_length(amino acids)=360AA_BP=32
MEGARVFGALGPIGPSSPGLTLGGLAVSEHRLSNKLLAWSGVLEWQEKRRPYSDSTAKLKRTLPCQAYVNQGENLETDQWPQKLIMQLIP
QQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCRIMGNGFAGCMLFPHISPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVSAIRQVITTR
KQAVGPGGVNSGPVQIVNNKFLAWSGVMEWQEPRPEPNSRSKRWLPSHVYVNQGEILRTEQWPRKLYMQLIPQQLLTTLVPLFRNSRLVQ
FHFTKDLETLKSLCRIMDNGFAGCVHFSYKASCEIRVLMLLYSSEKKIFIGLIPHDQGNFVNGIRRVIANQQQVLQRNLEQEQQQRGMGG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AP1S1-PTOV1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgenePTOV1chr7:100797798chr19:50357662ENST00000221557012184_41625.0375.0FLOT1
TgenePTOV1chr7:100797798chr19:50357662ENST00000391842012184_41657.0417.0FLOT1
TgenePTOV1chr7:100797798chr19:50357662ENST00000599732013184_41657.0357.6666666666667FLOT1
TgenePTOV1chr7:100797798chr19:50357662ENST00000600603013184_41625.0365.6666666666667FLOT1
TgenePTOV1chr7:100797798chr19:50357662ENST00000601675013184_41657.0383.6666666666667FLOT1
TgenePTOV1chr7:100797798chr19:50357663ENST00000221557012184_41625.0375.0FLOT1
TgenePTOV1chr7:100797798chr19:50357663ENST00000391842012184_41657.0417.0FLOT1
TgenePTOV1chr7:100797798chr19:50357663ENST00000599732013184_41657.0357.6666666666667FLOT1
TgenePTOV1chr7:100797798chr19:50357663ENST00000600603013184_41625.0365.6666666666667FLOT1
TgenePTOV1chr7:100797798chr19:50357663ENST00000601675013184_41657.0383.6666666666667FLOT1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AP1S1-PTOV1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AP1S1-PTOV1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAP1S1C1836330ERYTHROKERATODERMIA VARIABILIS 3 (disorder)3CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneAP1S1C0008372Intrahepatic Cholestasis1CTD_human
HgeneAP1S1C0023794Lipoidosis1CTD_human
TgeneC0024623Malignant neoplasm of stomach1CTD_human
TgeneC0038356Stomach Neoplasms1CTD_human
TgeneC0235874Disease Exacerbation1CTD_human
TgeneC1708349Hereditary Diffuse Gastric Cancer1CTD_human