Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ANTXR2-CHMP1A (FusionGDB2 ID:HG118429TG5119)

Fusion Gene Summary for ANTXR2-CHMP1A

check button Fusion gene summary
Fusion gene informationFusion gene name: ANTXR2-CHMP1A
Fusion gene ID: hg118429tg5119
HgeneTgene
Gene symbol

ANTXR2

CHMP1A

Gene ID

118429

5119

Gene nameANTXR cell adhesion molecule 2charged multivesicular body protein 1A
SynonymsCMG-2|CMG2|HFS|ISH|JHFCHMP1|PCH8|PCOLN3|PRSM1|VPS46-1|VPS46A
Cytomap('ANTXR2')('CHMP1A')

4q21.21

16q24.3

Type of geneprotein-codingprotein-coding
Descriptionanthrax toxin receptor 2capillary morphogenesis gene 2 proteincapillary morphogenesis protein 2charged multivesicular body protein 1acharged multivesicular body protein 1/chromatin modifying protein 1chromatin modifying protein 1Aprocollagen (type III) N-endopeptidaseprotease, metallo, 1, 33kDvacuolar protein sorting-associated protein 46-1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000403729, ENST00000404191, 
ENST00000295465, ENST00000307333, 
ENST00000346652, ENST00000482406, 
Fusion gene scores* DoF score6 X 6 X 4=14445 X 11 X 21=10395
# samples 748
** MAII scorelog2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(48/10395*10)=-4.43671154213721
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANTXR2 [Title/Abstract] AND CHMP1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANTXR2(80898775)-CHMP1A(89713739), # samples:2
Anticipated loss of major functional domain due to fusion event.ANTXR2-CHMP1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANTXR2-CHMP1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANTXR2-CHMP1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANTXR2-CHMP1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCHMP1A

GO:0007076

mitotic chromosome condensation

11559747

TgeneCHMP1A

GO:0016192

vesicle-mediated transport

11559748

TgeneCHMP1A

GO:0016458

gene silencing

11559747

TgeneCHMP1A

GO:0045892

negative regulation of transcription, DNA-templated

11559747


check buttonFusion gene breakpoints across ANTXR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CHMP1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-5506-01AANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
ChimerDB4PRADTCGA-EJ-7125-01AANTXR2chr4

80898775

-CHMP1Achr16

89713739

-


Top

Fusion Gene ORF analysis for ANTXR2-CHMP1A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000403729ENST00000547614ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
5CDS-5UTRENST00000404191ENST00000547614ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
Frame-shiftENST00000403729ENST00000253475ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
Frame-shiftENST00000404191ENST00000397901ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
Frame-shiftENST00000404191ENST00000535997ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
Frame-shiftENST00000404191ENST00000550102ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
In-frameENST00000403729ENST00000397901ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
In-frameENST00000403729ENST00000535997ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
In-frameENST00000403729ENST00000550102ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
In-frameENST00000404191ENST00000253475ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
intron-3CDSENST00000295465ENST00000253475ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
intron-3CDSENST00000295465ENST00000397901ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
intron-3CDSENST00000295465ENST00000535997ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
intron-3CDSENST00000295465ENST00000550102ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
intron-3CDSENST00000307333ENST00000253475ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
intron-3CDSENST00000307333ENST00000397901ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
intron-3CDSENST00000307333ENST00000535997ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
intron-3CDSENST00000307333ENST00000550102ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
intron-3CDSENST00000346652ENST00000253475ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
intron-3CDSENST00000346652ENST00000397901ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
intron-3CDSENST00000346652ENST00000535997ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
intron-3CDSENST00000346652ENST00000550102ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
intron-3CDSENST00000482406ENST00000253475ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
intron-3CDSENST00000482406ENST00000397901ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
intron-3CDSENST00000482406ENST00000535997ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
intron-3CDSENST00000482406ENST00000550102ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
intron-5UTRENST00000295465ENST00000547614ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
intron-5UTRENST00000307333ENST00000547614ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
intron-5UTRENST00000346652ENST00000547614ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-
intron-5UTRENST00000482406ENST00000547614ANTXR2chr4

80898775

-CHMP1Achr16

89713739

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000403729ANTXR2chr480898775-ENST00000397901CHMP1Achr1689713739-392819545262292588
ENST00000403729ANTXR2chr480898775-ENST00000535997CHMP1Achr1689713739-389619545262292588
ENST00000403729ANTXR2chr480898775-ENST00000550102CHMP1Achr1689713739-247019545262292588
ENST00000404191ANTXR2chr480898775-ENST00000253475CHMP1Achr1689713739-332113541571692511

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000403729ENST00000397901ANTXR2chr480898775-CHMP1Achr1689713739-0.0033515090.9966485
ENST00000403729ENST00000535997ANTXR2chr480898775-CHMP1Achr1689713739-0.0035567380.9964432
ENST00000403729ENST00000550102ANTXR2chr480898775-CHMP1Achr1689713739-0.0062750180.993725
ENST00000404191ENST00000253475ANTXR2chr480898775-CHMP1Achr1689713739-0.0016443410.9983557

Top

Fusion Genomic Features for ANTXR2-CHMP1A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for ANTXR2-CHMP1A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:80898775/chr16:89713739)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANTXR2chr4:80898775chr16:89713739ENST00000403729-1617352_360476489.0Compositional biasNote=Poly-Pro
HgeneANTXR2chr4:80898775chr16:89713739ENST00000403729-1617362_366476489.0Compositional biasNote=Poly-Glu
HgeneANTXR2chr4:80898775chr16:89713739ENST00000403729-161744_213476489.0DomainVWFA
HgeneANTXR2chr4:80898775chr16:89713739ENST00000403729-161734_318476489.0Topological domainExtracellular
HgeneANTXR2chr4:80898775chr16:89713739ENST00000403729-1617319_341476489.0TransmembraneHelical
TgeneCHMP1Achr4:80898775chr16:89713739ENST0000039790137102_12484197.0Coiled coilOntology_term=ECO:0000255
TgeneCHMP1Achr4:80898775chr16:89713739ENST0000039790137185_19584197.0MotifNote=MIT-interacting motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANTXR2chr4:80898775chr16:89713739ENST00000295465-111352_3600323.0Compositional biasNote=Poly-Pro
HgeneANTXR2chr4:80898775chr16:89713739ENST00000295465-111362_3660323.0Compositional biasNote=Poly-Glu
HgeneANTXR2chr4:80898775chr16:89713739ENST00000307333-116352_3600490.0Compositional biasNote=Poly-Pro
HgeneANTXR2chr4:80898775chr16:89713739ENST00000307333-116362_3660490.0Compositional biasNote=Poly-Glu
HgeneANTXR2chr4:80898775chr16:89713739ENST00000346652-112352_3600387.0Compositional biasNote=Poly-Pro
HgeneANTXR2chr4:80898775chr16:89713739ENST00000346652-112362_3660387.0Compositional biasNote=Poly-Glu
HgeneANTXR2chr4:80898775chr16:89713739ENST00000295465-11144_2130323.0DomainVWFA
HgeneANTXR2chr4:80898775chr16:89713739ENST00000307333-11644_2130490.0DomainVWFA
HgeneANTXR2chr4:80898775chr16:89713739ENST00000346652-11244_2130387.0DomainVWFA
HgeneANTXR2chr4:80898775chr16:89713739ENST00000295465-111342_4890323.0Topological domainCytoplasmic
HgeneANTXR2chr4:80898775chr16:89713739ENST00000295465-11134_3180323.0Topological domainExtracellular
HgeneANTXR2chr4:80898775chr16:89713739ENST00000307333-116342_4890490.0Topological domainCytoplasmic
HgeneANTXR2chr4:80898775chr16:89713739ENST00000307333-11634_3180490.0Topological domainExtracellular
HgeneANTXR2chr4:80898775chr16:89713739ENST00000346652-112342_4890387.0Topological domainCytoplasmic
HgeneANTXR2chr4:80898775chr16:89713739ENST00000346652-11234_3180387.0Topological domainExtracellular
HgeneANTXR2chr4:80898775chr16:89713739ENST00000403729-1617342_489476489.0Topological domainCytoplasmic
HgeneANTXR2chr4:80898775chr16:89713739ENST00000295465-111319_3410323.0TransmembraneHelical
HgeneANTXR2chr4:80898775chr16:89713739ENST00000307333-116319_3410490.0TransmembraneHelical
HgeneANTXR2chr4:80898775chr16:89713739ENST00000346652-112319_3410387.0TransmembraneHelical
TgeneCHMP1Achr4:80898775chr16:89713739ENST00000397901375_4784197.0Coiled coilOntology_term=ECO:0000255


Top

Fusion Gene Sequence for ANTXR2-CHMP1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4995_4995_1_ANTXR2-CHMP1A_ANTXR2_chr4_80898775_ENST00000403729_CHMP1A_chr16_89713739_ENST00000397901_length(transcript)=3928nt_BP=1954nt
TTTCGGAGTGCGGAGGGAGTTGGGGCCGCCGGAGGAGAAGAGTCTCCACTCCTAGTTTGTTCTGCCGTCGCCGCGTCCCAGGGACCCCTT
GTCCCGAAGCGCACGGCAGCGGGGGGGACTTCAGCCCTCCAGGCGGGGTGGGTTCCAGGTCCGGGTCCGAGGCGGGCGCTGGAGGCTCGG
CCCCAGGCCGGAGAGGAACTCCTTTCGCGAGCTGTCGCCGTGGGCCCGCATTGTCTGCAGGAACTCTCCGGAATCGGGAGGGGGAGGACT
GGATCGCGCTTCCACTGGGATTCGTCAAGAGTTCCGGCGGCAGCTGCGGCGGTGGCGGAGACTCCCTTTGTCCTCTCAGGACCTCCCTCT
CTCCCTCCCTGTCAGCTGGTGGGTCCCGCTGCCGCAGGCGCCGGCGTCTCAGCTGCTCGCCGCCCCCCACCCCAGAGTGCGTGCCGGGTG
ACTCCCGCCACCTTTGCGACCCTCCTGAGCTTAGGGGACTGCGAGCGGGAGGGAGTCTCAGGCCCCCGGCCGCAGGATGGTGGCGGAGCG
GTCCCCGGCCCGCAGCCCCGGGAGCTGGCTGTTCCCCGGGCTGTGGCTGTTGGTGCTCAGCGGTCCCGGGGGGCTGCTGCGCGCCCAGGA
GCAGCCCTCCTGCAGAAGAGCCTTTGATCTCTACTTCGTCCTGGACAAGTCTGGGAGTGTGGCAAATAACTGGATTGAAATTTATAATTT
CGTACAGCAACTTGCGGAGAGATTTGTGAGCCCTGAAATGAGATTATCTTTCATTGTGTTTTCTTCTCAAGCAACTATTATTTTGCCATT
AACTGGAGACAGAGGCAAAATCAGTAAAGGCTTGGAGGATTTAAAACGTGTTAGTCCAGTAGGAGAGACATATATCCATGAAGGACTAAA
GCTAGCGAATGAACAAATTCAGAAAGCAGGAGGCTTGAAAACCTCCAGTATCATAATTGCTCTGACAGATGGCAAGTTGGACGGTCTGGT
GCCATCATATGCAGAGAAAGAGGCAAAGATATCCAGGTCACTTGGGGCTAGTGTTTATTGTGTTGGTGTCCTTGATTTTGAACAAGCACA
GCTTGAAAGAATTGCTGATTCCAAGGAGCAAGTTTTCCCTGTCAAAGGTGGATTTCAGGCTCTTAAAGGAATAATTAATTCTATACTAGC
TCAGTCATGTACTGAAATCCTAGAATTGCAGCCCTCAAGTGTCTGTGTGGGGGAGGAATTTCAGATTGTCTTAAGTGGAAGAGGATTCAT
GCTGGGCAGTCGGAATGGCAGTGTTCTCTGCACTTACACTGTAAATGAAACATATACAACGAGTGTAAAACCAGTAAGTGTACAGCTTAA
TTCTATGCTTTGTCCTGCACCTATCCTGAATAAAGCTGGAGAAACTCTTGATGTTTCAGTGAGCTTTAATGGAGGAAAATCTGTCATTTC
AGGATCATTAATTGTCACAGCCACAGAATGTTCTAACGGGATCGCAGCCATCATTGTTATTTTGGTGTTACTGCTACTCCTGGGGATCGG
TTTGATGTGGTGGTTTTGGCCCCTTTGCTGCAAAGTGGTTATTAAGGATCCTCCACCACCACCCGCCCCTGCACCAAAAGAGGAGGAAGA
AGAACCTTTGCCTACTAAAAAGTGGCCAACTGTGGATGCTTCCTATTATGGTGGTCGAGGGGTTGGAGGAATTAAAAGAATGGAGGTTCG
TTGGGGTGATAAAGGATCTACTGAGGAAGGTGCAAGGCTAGAGAAAGCCAAAAATGCTGTGGTGAAGATTCCTGAAGAAACAGAGGAACC
CATCAGGCCTAGACCACCTCGACCCAAACCCACACACCAGCCTCCTCAGACAAAATGGTACACCCCAATTAAGGGTCGTCTTGATGCTCT
CTGGGCTTTGTTGAGGCGGCAGTATGACCGGGTTTCTTTGATGCGACCTCAGGAAGGAGATGAGGTGACCAAGAATATGGCCCAGGTGAC
CAAAGCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGATGGACAGGTTCGAGCAGCAGGTGCAGAACCTGGA
CGTCCATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGCCGCAGGAGCAGGTGGACAGCCTCATCATGCAGAT
CGCCGAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCGCCTCTGCCGTGGGCGAGAGCTCTGTGCGCAGCCA
GGAGGACCAGCTGTCACGGAGGTTGGCCGCCTTGAGGAACTAGCCGTGCCCCGCCGGTGTGCACCGCCTCTGCCCCGTGATGTGCTGGAA
GGCTCCTGTCCTCTCCCCACCGCGTCTTGCCTTTGTGCTGACCCCGCGGGGCTGCGGCCGGCAGCCACTCTGCGTCTCTCACCTGCCAGG
CCTGCGTGGCCTTAGGGTTGTTCCTGTTCTTTTAGGTTGGGCGGTGGGTCTGTGTCCTGGTGTTGAGTTTCTGCAAATTTCTGGGGGTGA
TTTCTGTGACTCTGGGCCCACAGCGGGGAGGCCAAGAGGGGCCCTGTGGACTTTCACCCAGCACTGTGGGGGCCTTCAGACTCTGGGGCA
GCAGACATGCTGCTTCCCATCAGCCAGAGGGGGTCAGGGCTGCCCTGTTGCCAAACAACTCCCTGAGGCCTCTCCGCACCACCTCAGCGG
GCAGGAGGTCCCACCATGTGGACAGACATAGCCCAAGGAGGCACCACAGGTCTATGTGTGCTGGGGGATGTCAGGTGCCACCCAACGCTG
TCCTGGTGGTATTTACAATGACATCCTCCTCCTCCATCACTCCAGGGGTGGTGTCTCGGCCGCCCCTACCAGCTGGCTGAGCCCCCTGGC
CTCCTGCGCTCCCTCACTTCCCTCAGTTCCCAAAGCTGCCCAGTCCATGGGGACAGAACCGTCACTCAGATCCACATTCAAGTGTGCCCA
CCCTGCAGTCTTCATCCTCACTCAGCTGCTGCCTCTGGAGGTGCCTTTGGCCACATGTGCTGTGCTGTTTGTCTCCTCGACAGGGAGCCT
GTCCACCAGCAGGCTGCGGTCCCAGCGGGTGCGTCTGCAGCTCCTCCCCTTGGGCAGCCTGGTTCTCCCGGAGGACCTTTCCTTGGGGCC
CTGCTTCATGACGATGCTGCCTGTGTCACCCTCTACCATCTGTAAACAACTGGGTGCCTTCCCCGACCACACCCCAATGCCTTCCCAGCT
TGGAAGCCAAGGCAGCTGATGAAGGGAGCTCAGGAGAGCCGTCTTCAGCTGGGCTGGGGTTGGGGCTGCTGTGAGGAAAACCTGCCATTG
TGGCCCTGGAGAGTCACCAGCAGCTCTTGGGAAGGACTTGCTGGGAGGCTGAGAGAGGCTTTGGGCACAGCCTGCTGTCTTTTCCATTTC
CTAAAGTTTACTTCATTGTCTTGAGGCTTCCAGGTTTTGTTTTTGTTTTTGCCAAAGTAGAAAAGGCAGGTGGTGGGCGGCTGGCAGGGA
GTGCGGGTCCCCGCCCCTCTTCAGTCCTGCCCTCCCCTCCTCAGTCCTGCCCACCCCGTGCAGCCCATGCTGAGGCTGCAGTGGTGTCGT
GGGTGTTACGTGCAGGAACGTGGAGACCCTGACGTGGGCTCACTGCGTTTGGTTTTCTTTTCAGAACTTGGGAGCCCCCAGGGAGGGGCT
AGTGTTGGTAGGTCCTAGACGTGGTTCCCTCCAGCCTCCCCAAAATCAACCCTGGTGTTGAGAGAACGTCCTTCTGTCCATCGTGGGTAA
CAGCCTTGGGGAGGGTGCAGAGCTCTGCAGAGCCATGGGCCAGGTGGGGCTGCCTCAGTCCTGTCCCCTTGGGCACTGAGGAGAGGGGCC
CATTCACCTTTCTCCTAGAATGCTGTTGTAAATAAACAAATGGATCCCTGGAAACTTT

>4995_4995_1_ANTXR2-CHMP1A_ANTXR2_chr4_80898775_ENST00000403729_CHMP1A_chr16_89713739_ENST00000397901_length(amino acids)=588AA_BP=476
MVAERSPARSPGSWLFPGLWLLVLSGPGGLLRAQEQPSCRRAFDLYFVLDKSGSVANNWIEIYNFVQQLAERFVSPEMRLSFIVFSSQAT
IILPLTGDRGKISKGLEDLKRVSPVGETYIHEGLKLANEQIQKAGGLKTSSIIIALTDGKLDGLVPSYAEKEAKISRSLGASVYCVGVLD
FEQAQLERIADSKEQVFPVKGGFQALKGIINSILAQSCTEILELQPSSVCVGEEFQIVLSGRGFMLGSRNGSVLCTYTVNETYTTSVKPV
SVQLNSMLCPAPILNKAGETLDVSVSFNGGKSVISGSLIVTATECSNGIAAIIVILVLLLLLGIGLMWWFWPLCCKVVIKDPPPPPAPAP
KEEEEEPLPTKKWPTVDASYYGGRGVGGIKRMEVRWGDKGSTEEGARLEKAKNAVVKIPEETEEPIRPRPPRPKPTHQPPQTKWYTPIKG
RLDALWALLRRQYDRVSLMRPQEGDEVTKNMAQVTKALDKALSTMDLQKVSSVMDRFEQQVQNLDVHTSVMEDSMSSATTLTTPQEQVDS
LIMQIAEENGLEVLDQLSQLPEGASAVGESSVRSQEDQLSRRLAALRN

--------------------------------------------------------------
>4995_4995_2_ANTXR2-CHMP1A_ANTXR2_chr4_80898775_ENST00000403729_CHMP1A_chr16_89713739_ENST00000535997_length(transcript)=3896nt_BP=1954nt
TTTCGGAGTGCGGAGGGAGTTGGGGCCGCCGGAGGAGAAGAGTCTCCACTCCTAGTTTGTTCTGCCGTCGCCGCGTCCCAGGGACCCCTT
GTCCCGAAGCGCACGGCAGCGGGGGGGACTTCAGCCCTCCAGGCGGGGTGGGTTCCAGGTCCGGGTCCGAGGCGGGCGCTGGAGGCTCGG
CCCCAGGCCGGAGAGGAACTCCTTTCGCGAGCTGTCGCCGTGGGCCCGCATTGTCTGCAGGAACTCTCCGGAATCGGGAGGGGGAGGACT
GGATCGCGCTTCCACTGGGATTCGTCAAGAGTTCCGGCGGCAGCTGCGGCGGTGGCGGAGACTCCCTTTGTCCTCTCAGGACCTCCCTCT
CTCCCTCCCTGTCAGCTGGTGGGTCCCGCTGCCGCAGGCGCCGGCGTCTCAGCTGCTCGCCGCCCCCCACCCCAGAGTGCGTGCCGGGTG
ACTCCCGCCACCTTTGCGACCCTCCTGAGCTTAGGGGACTGCGAGCGGGAGGGAGTCTCAGGCCCCCGGCCGCAGGATGGTGGCGGAGCG
GTCCCCGGCCCGCAGCCCCGGGAGCTGGCTGTTCCCCGGGCTGTGGCTGTTGGTGCTCAGCGGTCCCGGGGGGCTGCTGCGCGCCCAGGA
GCAGCCCTCCTGCAGAAGAGCCTTTGATCTCTACTTCGTCCTGGACAAGTCTGGGAGTGTGGCAAATAACTGGATTGAAATTTATAATTT
CGTACAGCAACTTGCGGAGAGATTTGTGAGCCCTGAAATGAGATTATCTTTCATTGTGTTTTCTTCTCAAGCAACTATTATTTTGCCATT
AACTGGAGACAGAGGCAAAATCAGTAAAGGCTTGGAGGATTTAAAACGTGTTAGTCCAGTAGGAGAGACATATATCCATGAAGGACTAAA
GCTAGCGAATGAACAAATTCAGAAAGCAGGAGGCTTGAAAACCTCCAGTATCATAATTGCTCTGACAGATGGCAAGTTGGACGGTCTGGT
GCCATCATATGCAGAGAAAGAGGCAAAGATATCCAGGTCACTTGGGGCTAGTGTTTATTGTGTTGGTGTCCTTGATTTTGAACAAGCACA
GCTTGAAAGAATTGCTGATTCCAAGGAGCAAGTTTTCCCTGTCAAAGGTGGATTTCAGGCTCTTAAAGGAATAATTAATTCTATACTAGC
TCAGTCATGTACTGAAATCCTAGAATTGCAGCCCTCAAGTGTCTGTGTGGGGGAGGAATTTCAGATTGTCTTAAGTGGAAGAGGATTCAT
GCTGGGCAGTCGGAATGGCAGTGTTCTCTGCACTTACACTGTAAATGAAACATATACAACGAGTGTAAAACCAGTAAGTGTACAGCTTAA
TTCTATGCTTTGTCCTGCACCTATCCTGAATAAAGCTGGAGAAACTCTTGATGTTTCAGTGAGCTTTAATGGAGGAAAATCTGTCATTTC
AGGATCATTAATTGTCACAGCCACAGAATGTTCTAACGGGATCGCAGCCATCATTGTTATTTTGGTGTTACTGCTACTCCTGGGGATCGG
TTTGATGTGGTGGTTTTGGCCCCTTTGCTGCAAAGTGGTTATTAAGGATCCTCCACCACCACCCGCCCCTGCACCAAAAGAGGAGGAAGA
AGAACCTTTGCCTACTAAAAAGTGGCCAACTGTGGATGCTTCCTATTATGGTGGTCGAGGGGTTGGAGGAATTAAAAGAATGGAGGTTCG
TTGGGGTGATAAAGGATCTACTGAGGAAGGTGCAAGGCTAGAGAAAGCCAAAAATGCTGTGGTGAAGATTCCTGAAGAAACAGAGGAACC
CATCAGGCCTAGACCACCTCGACCCAAACCCACACACCAGCCTCCTCAGACAAAATGGTACACCCCAATTAAGGGTCGTCTTGATGCTCT
CTGGGCTTTGTTGAGGCGGCAGTATGACCGGGTTTCTTTGATGCGACCTCAGGAAGGAGATGAGGTGACCAAGAATATGGCCCAGGTGAC
CAAAGCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGATGGACAGGTTCGAGCAGCAGGTGCAGAACCTGGA
CGTCCATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGCCGCAGGAGCAGGTGGACAGCCTCATCATGCAGAT
CGCCGAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCGCCTCTGCCGTGGGCGAGAGCTCTGTGCGCAGCCA
GGAGGACCAGCTGTCACGGAGGTTGGCCGCCTTGAGGAACTAGCCGTGCCCCGCCGGTGTGCACCGCCTCTGCCCCGTGATGTGCTGGAA
GGCTCCTGTCCTCTCCCCACCGCGTCTTGCCTTTGTGCTGACCCCGCGGGGCTGCGGCCGGCAGCCACTCTGCGTCTCTCACCTGCCAGG
CCTGCGTGGCCTTAGGGTTGTTCCTGTTCTTTTAGGTTGGGCGGTGGGTCTGTGTCCTGGTGTTGAGTTTCTGCAAATTTCTGGGGGTGA
TTTCTGTGACTCTGGGCCCACAGCGGGGAGGCCAAGAGGGGCCCTGTGGACTTTCACCCAGCACTGTGGGGGCCTTCAGACTCTGGGGCA
GCAGACATGCTGCTTCCCATCAGCCAGAGGGGGTCAGGGCTGCCCTGTTGCCAAACAACTCCCTGAGGCCTCTCCGCACCACCTCAGCGG
GCAGGAGGTCCCACCATGTGGACAGACATAGCCCAAGGAGGCACCACAGGTCTATGTGTGCTGGGGGATGTCAGGTGCCACCCAACGCTG
TCCTGGTGGTATTTACAATGACATCCTCCTCCTCCATCACTCCAGGGGTGGTGTCTCGGCCGCCCCTACCAGCTGGCTGAGCCCCCTGGC
CTCCTGCGCTCCCTCACTTCCCTCAGTTCCCAAAGCTGCCCAGTCCATGGGGACAGAACCGTCACTCAGATCCACATTCAAGTGTGCCCA
CCCTGCAGTCTTCATCCTCACTCAGCTGCTGCCTCTGGAGGTGCCTTTGGCCACATGTGCTGTGCTGTTTGTCTCCTCGACAGGGAGCCT
GTCCACCAGCAGGCTGCGGTCCCAGCGGGTGCGTCTGCAGCTCCTCCCCTTGGGCAGCCTGGTTCTCCCGGAGGACCTTTCCTTGGGGCC
CTGCTTCATGACGATGCTGCCTGTGTCACCCTCTACCATCTGTAAACAACTGGGTGCCTTCCCCGACCACACCCCAATGCCTTCCCAGCT
TGGAAGCCAAGGCAGCTGATGAAGGGAGCTCAGGAGAGCCGTCTTCAGCTGGGCTGGGGTTGGGGCTGCTGTGAGGAAAACCTGCCATTG
TGGCCCTGGAGAGTCACCAGCAGCTCTTGGGAAGGACTTGCTGGGAGGCTGAGAGAGGCTTTGGGCACAGCCTGCTGTCTTTTCCATTTC
CTAAAGTTTACTTCATTGTCTTGAGGCTTCCAGGTTTTGTTTTTGTTTTTGCCAAAGTAGAAAAGGCAGGTGGTGGGCGGCTGGCAGGGA
GTGCGGGTCCCCGCCCCTCTTCAGTCCTGCCCTCCCCTCCTCAGTCCTGCCCACCCCGTGCAGCCCATGCTGAGGCTGCAGTGGTGTCGT
GGGTGTTACGTGCAGGAACGTGGAGACCCTGACGTGGGCTCACTGCGTTTGGTTTTCTTTTCAGAACTTGGGAGCCCCCAGGGAGGGGCT
AGTGTTGGTAGGTCCTAGACGTGGTTCCCTCCAGCCTCCCCAAAATCAACCCTGGTGTTGAGAGAACGTCCTTCTGTCCATCGTGGGTAA
CAGCCTTGGGGAGGGTGCAGAGCTCTGCAGAGCCATGGGCCAGGTGGGGCTGCCTCAGTCCTGTCCCCTTGGGCACTGAGGAGAGGGGCC
CATTCACCTTTCTCCTAGAATGCTGT

>4995_4995_2_ANTXR2-CHMP1A_ANTXR2_chr4_80898775_ENST00000403729_CHMP1A_chr16_89713739_ENST00000535997_length(amino acids)=588AA_BP=476
MVAERSPARSPGSWLFPGLWLLVLSGPGGLLRAQEQPSCRRAFDLYFVLDKSGSVANNWIEIYNFVQQLAERFVSPEMRLSFIVFSSQAT
IILPLTGDRGKISKGLEDLKRVSPVGETYIHEGLKLANEQIQKAGGLKTSSIIIALTDGKLDGLVPSYAEKEAKISRSLGASVYCVGVLD
FEQAQLERIADSKEQVFPVKGGFQALKGIINSILAQSCTEILELQPSSVCVGEEFQIVLSGRGFMLGSRNGSVLCTYTVNETYTTSVKPV
SVQLNSMLCPAPILNKAGETLDVSVSFNGGKSVISGSLIVTATECSNGIAAIIVILVLLLLLGIGLMWWFWPLCCKVVIKDPPPPPAPAP
KEEEEEPLPTKKWPTVDASYYGGRGVGGIKRMEVRWGDKGSTEEGARLEKAKNAVVKIPEETEEPIRPRPPRPKPTHQPPQTKWYTPIKG
RLDALWALLRRQYDRVSLMRPQEGDEVTKNMAQVTKALDKALSTMDLQKVSSVMDRFEQQVQNLDVHTSVMEDSMSSATTLTTPQEQVDS
LIMQIAEENGLEVLDQLSQLPEGASAVGESSVRSQEDQLSRRLAALRN

--------------------------------------------------------------
>4995_4995_3_ANTXR2-CHMP1A_ANTXR2_chr4_80898775_ENST00000403729_CHMP1A_chr16_89713739_ENST00000550102_length(transcript)=2470nt_BP=1954nt
TTTCGGAGTGCGGAGGGAGTTGGGGCCGCCGGAGGAGAAGAGTCTCCACTCCTAGTTTGTTCTGCCGTCGCCGCGTCCCAGGGACCCCTT
GTCCCGAAGCGCACGGCAGCGGGGGGGACTTCAGCCCTCCAGGCGGGGTGGGTTCCAGGTCCGGGTCCGAGGCGGGCGCTGGAGGCTCGG
CCCCAGGCCGGAGAGGAACTCCTTTCGCGAGCTGTCGCCGTGGGCCCGCATTGTCTGCAGGAACTCTCCGGAATCGGGAGGGGGAGGACT
GGATCGCGCTTCCACTGGGATTCGTCAAGAGTTCCGGCGGCAGCTGCGGCGGTGGCGGAGACTCCCTTTGTCCTCTCAGGACCTCCCTCT
CTCCCTCCCTGTCAGCTGGTGGGTCCCGCTGCCGCAGGCGCCGGCGTCTCAGCTGCTCGCCGCCCCCCACCCCAGAGTGCGTGCCGGGTG
ACTCCCGCCACCTTTGCGACCCTCCTGAGCTTAGGGGACTGCGAGCGGGAGGGAGTCTCAGGCCCCCGGCCGCAGGATGGTGGCGGAGCG
GTCCCCGGCCCGCAGCCCCGGGAGCTGGCTGTTCCCCGGGCTGTGGCTGTTGGTGCTCAGCGGTCCCGGGGGGCTGCTGCGCGCCCAGGA
GCAGCCCTCCTGCAGAAGAGCCTTTGATCTCTACTTCGTCCTGGACAAGTCTGGGAGTGTGGCAAATAACTGGATTGAAATTTATAATTT
CGTACAGCAACTTGCGGAGAGATTTGTGAGCCCTGAAATGAGATTATCTTTCATTGTGTTTTCTTCTCAAGCAACTATTATTTTGCCATT
AACTGGAGACAGAGGCAAAATCAGTAAAGGCTTGGAGGATTTAAAACGTGTTAGTCCAGTAGGAGAGACATATATCCATGAAGGACTAAA
GCTAGCGAATGAACAAATTCAGAAAGCAGGAGGCTTGAAAACCTCCAGTATCATAATTGCTCTGACAGATGGCAAGTTGGACGGTCTGGT
GCCATCATATGCAGAGAAAGAGGCAAAGATATCCAGGTCACTTGGGGCTAGTGTTTATTGTGTTGGTGTCCTTGATTTTGAACAAGCACA
GCTTGAAAGAATTGCTGATTCCAAGGAGCAAGTTTTCCCTGTCAAAGGTGGATTTCAGGCTCTTAAAGGAATAATTAATTCTATACTAGC
TCAGTCATGTACTGAAATCCTAGAATTGCAGCCCTCAAGTGTCTGTGTGGGGGAGGAATTTCAGATTGTCTTAAGTGGAAGAGGATTCAT
GCTGGGCAGTCGGAATGGCAGTGTTCTCTGCACTTACACTGTAAATGAAACATATACAACGAGTGTAAAACCAGTAAGTGTACAGCTTAA
TTCTATGCTTTGTCCTGCACCTATCCTGAATAAAGCTGGAGAAACTCTTGATGTTTCAGTGAGCTTTAATGGAGGAAAATCTGTCATTTC
AGGATCATTAATTGTCACAGCCACAGAATGTTCTAACGGGATCGCAGCCATCATTGTTATTTTGGTGTTACTGCTACTCCTGGGGATCGG
TTTGATGTGGTGGTTTTGGCCCCTTTGCTGCAAAGTGGTTATTAAGGATCCTCCACCACCACCCGCCCCTGCACCAAAAGAGGAGGAAGA
AGAACCTTTGCCTACTAAAAAGTGGCCAACTGTGGATGCTTCCTATTATGGTGGTCGAGGGGTTGGAGGAATTAAAAGAATGGAGGTTCG
TTGGGGTGATAAAGGATCTACTGAGGAAGGTGCAAGGCTAGAGAAAGCCAAAAATGCTGTGGTGAAGATTCCTGAAGAAACAGAGGAACC
CATCAGGCCTAGACCACCTCGACCCAAACCCACACACCAGCCTCCTCAGACAAAATGGTACACCCCAATTAAGGGTCGTCTTGATGCTCT
CTGGGCTTTGTTGAGGCGGCAGTATGACCGGGTTTCTTTGATGCGACCTCAGGAAGGAGATGAGGTGACCAAGAATATGGCCCAGGTGAC
CAAAGCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGATGGACAGGTTCGAGCAGCAGGTGCAGAACCTGGA
CGTCCATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGCCGCAGGAGCAGGTGGACAGCCTCATCATGCAGAT
CGCCGAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCGCCTCTGCCGTGGGCGAGAGCTCTGTGCGCAGCCA
GGAGGACCAGCTGTCACGGAGGTTGGCCGCCTTGAGGAACTAGCCGTGCCCCGCCGGTGTGCACCGCCTCTGCCCCGTGATGTGCTGGAA
GGCTCCTGTCCTCTCCCCACCGCGTCTTGCCTTTGTGCTGACCCCGCGGGGCTGCGGCCGGCAGCCACTCTGCGTCTCTCACCTGCCAGG
CCTGCGTGGCCTTAGGGTTGTTCCTGTTCTTTTAGGTTGG

>4995_4995_3_ANTXR2-CHMP1A_ANTXR2_chr4_80898775_ENST00000403729_CHMP1A_chr16_89713739_ENST00000550102_length(amino acids)=588AA_BP=476
MVAERSPARSPGSWLFPGLWLLVLSGPGGLLRAQEQPSCRRAFDLYFVLDKSGSVANNWIEIYNFVQQLAERFVSPEMRLSFIVFSSQAT
IILPLTGDRGKISKGLEDLKRVSPVGETYIHEGLKLANEQIQKAGGLKTSSIIIALTDGKLDGLVPSYAEKEAKISRSLGASVYCVGVLD
FEQAQLERIADSKEQVFPVKGGFQALKGIINSILAQSCTEILELQPSSVCVGEEFQIVLSGRGFMLGSRNGSVLCTYTVNETYTTSVKPV
SVQLNSMLCPAPILNKAGETLDVSVSFNGGKSVISGSLIVTATECSNGIAAIIVILVLLLLLGIGLMWWFWPLCCKVVIKDPPPPPAPAP
KEEEEEPLPTKKWPTVDASYYGGRGVGGIKRMEVRWGDKGSTEEGARLEKAKNAVVKIPEETEEPIRPRPPRPKPTHQPPQTKWYTPIKG
RLDALWALLRRQYDRVSLMRPQEGDEVTKNMAQVTKALDKALSTMDLQKVSSVMDRFEQQVQNLDVHTSVMEDSMSSATTLTTPQEQVDS
LIMQIAEENGLEVLDQLSQLPEGASAVGESSVRSQEDQLSRRLAALRN

--------------------------------------------------------------
>4995_4995_4_ANTXR2-CHMP1A_ANTXR2_chr4_80898775_ENST00000404191_CHMP1A_chr16_89713739_ENST00000253475_length(transcript)=3321nt_BP=1354nt
AGTCTTGGGTTTGTGAACCACGCATGGGGGCTGTTTTAGCACAGCTGCTAAAATAGGCCAGGCCTGCAGGACATACGGGTCTGGGAGTGT
GGCAAATAACTGGATTGAAATTTATAATTTCGTACAGCAACTTGCGGAGAGATTTGTGAGCCCTGAAATGAGATTATCTTTCATTGTGTT
TTCTTCTCAAGCAACTATTATTTTGCCATTAACTGGAGACAGAGGCAAAATCAGTAAAGGCTTGGAGGATTTAAAACGTGTTAGTCCAGT
AGGAGAGACATATATCCATGAAGGACTAAAGCTAGCGAATGAACAAATTCAGAAAGCAGGAGGCTTGAAAACCTCCAGTATCATAATTGC
TCTGACAGATGGCAAGTTGGACGGTCTGGTGCCATCATATGCAGAGAAAGAGGCAAAGATATCCAGGTCACTTGGGGCTAGTGTTTATTG
TGTTGGTGTCCTTGATTTTGAACAAGCACAGCTTGAAAGAATTGCTGATTCCAAGGAGCAAGTTTTCCCTGTCAAAGGTGGATTTCAGGC
TCTTAAAGGAATAATTAATTCTATACTAGCTCAGTCATGTACTGAAATCCTAGAATTGCAGCCCTCAAGTGTCTGTGTGGGGGAGGAATT
TCAGATTGTCTTAAGTGGAAGAGGATTCATGCTGGGCAGTCGGAATGGCAGTGTTCTCTGCACTTACACTGTAAATGAAACATATACAAC
GAGTGTAAAACCAGTAAGTGTACAGCTTAATTCTATGCTTTGTCCTGCACCTATCCTGAATAAAGCTGGAGAAACTCTTGATGTTTCAGT
GAGCTTTAATGGAGGAAAATCTGTCATTTCAGGATCATTAATTGTCACAGCCACAGAATGTTCTAACGGGATCGCAGCCATCATTGTTAT
TTTGGTGTTACTGCTACTCCTGGGGATCGGTTTGATGTGGTGGTTTTGGCCCCTTTGCTGCAAAGTGGTTATTAAGGATCCTCCACCACC
ACCCGCCCCTGCACCAAAAGAGGAGGAAGAAGAACCTTTGCCTACTAAAAAGTGGCCAACTGTGGATGCTTCCTATTATGGTGGTCGAGG
GGTTGGAGGAATTAAAAGAATGGAGGTTCGTTGGGGTGATAAAGGATCTACTGAGGAAGGTGCAAGGCTAGAGAAAGCCAAAAATGCTGT
GGTGAAGATTCCTGAAGAAACAGAGGAACCCATCAGGCCTAGACCACCTCGACCCAAACCCACACACCAGCCTCCTCAGACAAAATGGTA
CACCCCAATTAAGGGTCGTCTTGATGCTCTCTGGGCTTTGTTGAGGCGGCAGTATGACCGGGTTTCTTTGATGCGACCTCAGGAAGGAGA
TGAGGTGACCAAGAATATGGCCCAGGTGACCAAAGCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGATGGA
CAGGTTCGAGCAGCAGGTGCAGAACCTGGACGTCCATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGCCGCA
GGAGCAGGTGGACAGCCTCATCATGCAGATCGCCGAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCGCCTC
TGCCGTGGGCGAGAGCTCTGTGCGCAGCCAGGAGGACCAGCTGTCACGGAGGTTGGCCGCCTTGAGGAACTAGCCGTGCCCCGCCGGTGT
GCACCGCCTCTGCCCCGTGATGTGCTGGAAGGCTCCTGTCCTCTCCCCACCGCGTCTTGCCTTTGTGCTGACCCCGCGGGGCTGCGGCCG
GCAGCCACTCTGCGTCTCTCACCTGCCAGGCCTGCGTGGCCTTAGGGTTGTTCCTGTTCTTTTAGGTTGGGCGGTGGGTCTGTGTCCTGG
TGTTGAGTTTCTGCAAATTTCTGGGGGTGATTTCTGTGACTCTGGGCCCACAGCGGGGAGGCCAAGAGGGGCCCTGTGGACTTTCACCCA
GCACTGTGGGGGCCTTCAGACTCTGGGGCAGCAGACATGCTGCTTCCCATCAGCCAGAGGGGGTCAGGGCTGCCCTGTTGCCAAACAACT
CCCTGAGGCCTCTCCGCACCACCTCAGCGGGCAGGAGGTCCCACCATGTGGACAGACATAGCCCAAGGAGGCACCACAGGTCTATGTGTG
CTGGGGGATGTCAGGTGCCACCCAACGCTGTCCTGGTGGTATTTACAATGACATCCTCCTCCTCCATCACTCCAGGGGTGGTGTCTCGGC
CGCCCCTACCAGCTGGCTGAGCCCCCTGGCCTCCTGCGCTCCCTCACTTCCCTCAGTTCCCAAAGCTGCCCAGTCCATGGGGACAGAACC
GTCACTCAGATCCACATTCAAGTGTGCCCACCCTGCAGTCTTCATCCTCACTCAGCTGCTGCCTCTGGAGGTGCCTTTGGCCACATGTGC
TGTGCTGTTTGTCTCCTCGACAGGGAGCCTGTCCACCAGCAGGCTGCGGTCCCAGCGGGTGCGTCTGCAGCTCCTCCCCTTGGGCAGCCT
GGTTCTCCCGGAGGACCTTTCCTTGGGGCCCTGCTTCATGACGATGCTGCCTGTGTCACCCTCTACCATCTGTAAACAACTGGGTGCCTT
CCCCGACCACACCCCAATGCCTTCCCAGCTTGGAAGCCAAGGCAGCTGATGAAGGGAGCTCAGGAGAGCCGTCTTCAGCTGGGCTGGGGT
TGGGGCTGCTGTGAGGAAAACCTGCCATTGTGGCCCTGGAGAGTCACCAGCAGCTCTTGGGAAGGACTTGCTGGGAGGCTGAGAGAGGCT
TTGGGCACAGCCTGCTGTCTTTTCCATTTCCTAAAGTTTACTTCATTGTCTTGAGGCTTCCAGGTTTTGTTTTTGTTTTTGCCAAAGTAG
AAAAGGCAGGTGGTGGGCGGCTGGCAGGGAGTGCGGGTCCCCGCCCCTCTTCAGTCCTGCCCTCCCCTCCTCAGTCCTGCCCACCCCGTG
CAGCCCATGCTGAGGCTGCAGTGGTGTCGTGGGTGTTACGTGCAGGAACGTGGAGACCCTGACGTGGGCTCACTGCGTTTGGTTTTCTTT
TCAGAACTTGGGAGCCCCCAGGGAGGGGCTAGTGTTGGTAGGTCCTAGACGTGGTTCCCTCCAGCCTCCCCAAAATCAACCCTGGTGTTG
AGAGAACGTCCTTCTGTCCATCGTGGGTAACAGCCTTGGGGAGGGTGCAGAGCTCTGCAGAGCCATGGGCCAGGTGGGGCTGCCTCAGTC
CTGTCCCCTTGGGCACTGAGGAGAGGGGCCCATTCACCTTTCTCCTAGAATGCTGTTGTAAATAAACAAATGGATCCCTGG

>4995_4995_4_ANTXR2-CHMP1A_ANTXR2_chr4_80898775_ENST00000404191_CHMP1A_chr16_89713739_ENST00000253475_length(amino acids)=511AA_BP=399
MRLSFIVFSSQATIILPLTGDRGKISKGLEDLKRVSPVGETYIHEGLKLANEQIQKAGGLKTSSIIIALTDGKLDGLVPSYAEKEAKISR
SLGASVYCVGVLDFEQAQLERIADSKEQVFPVKGGFQALKGIINSILAQSCTEILELQPSSVCVGEEFQIVLSGRGFMLGSRNGSVLCTY
TVNETYTTSVKPVSVQLNSMLCPAPILNKAGETLDVSVSFNGGKSVISGSLIVTATECSNGIAAIIVILVLLLLLGIGLMWWFWPLCCKV
VIKDPPPPPAPAPKEEEEEPLPTKKWPTVDASYYGGRGVGGIKRMEVRWGDKGSTEEGARLEKAKNAVVKIPEETEEPIRPRPPRPKPTH
QPPQTKWYTPIKGRLDALWALLRRQYDRVSLMRPQEGDEVTKNMAQVTKALDKALSTMDLQKVSSVMDRFEQQVQNLDVHTSVMEDSMSS
ATTLTTPQEQVDSLIMQIAEENGLEVLDQLSQLPEGASAVGESSVRSQEDQLSRRLAALRN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ANTXR2-CHMP1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ANTXR2-CHMP1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ANTXR2-CHMP1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANTXR2C2745948Hyalinosis, Systemic3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneANTXR2C0009917Contracture2CTD_human
HgeneANTXR2C0016045fibroma2CTD_human
HgeneANTXR2C0016048Fibromatosis2CTD_human
HgeneANTXR2C0017567Gingival Hypertrophy2CTD_human
HgeneANTXR2C0038013Ankylosing spondylitis2CTD_human
HgeneANTXR2C0205766Myxofibroma2CTD_human
HgeneANTXR2C0001787Osteoporosis, Age-Related1CTD_human
HgeneANTXR2C0029456Osteoporosis1CTD_human
HgeneANTXR2C0029459Osteoporosis, Senile1CTD_human
HgeneANTXR2C0033578Prostatic Neoplasms1CTD_human
HgeneANTXR2C0376358Malignant neoplasm of prostate1CTD_human
HgeneANTXR2C0751406Post-Traumatic Osteoporosis1CTD_human
HgeneANTXR2C4721411Osteolysis1CTD_human
TgeneC0266468Congenital pontocerebellar hypoplasia1GENOMICS_ENGLAND
TgeneC3554209Congenital pontocerebellar hypoplasia type 81CTD_human;GENOMICS_ENGLAND;ORPHANET