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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C10orf90-ADAM12 (FusionGDB2 ID:HG118611TG8038)

Fusion Gene Summary for C10orf90-ADAM12

check button Fusion gene summary
Fusion gene informationFusion gene name: C10orf90-ADAM12
Fusion gene ID: hg118611tg8038
HgeneTgene
Gene symbol

C10orf90

ADAM12

Gene ID

118611

8038

Gene namechromosome 10 open reading frame 90ADAM metallopeptidase domain 12
SynonymsFATS|bA422P15.2ADAM12-OT1|CAR10|MCMP|MCMPMltna|MLTN|MLTNA
Cytomap('C10orf90')('ADAM12')

10q26.2

10q26.2

Type of geneprotein-codingprotein-coding
Description(E2-independent) E3 ubiquitin-conjugating enzyme FATSE2/E3 hybrid ubiquitin-protein ligase FATScentrosomal protein C10orf90fragile-site associated tumor suppressor homologdisintegrin and metalloproteinase domain-containing protein 12meltrin-alphametalloprotease-disintegrin 12 transmembrane
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000544758, ENST00000284694, 
ENST00000356858, ENST00000368674, 
ENST00000392694, ENST00000454341, 
ENST00000480379, 
Fusion gene scores* DoF score3 X 4 X 2=2414 X 15 X 4=840
# samples 417
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(17/840*10)=-2.30485458152842
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C10orf90 [Title/Abstract] AND ADAM12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC10orf90(128358810)-ADAM12(128019078), # samples:1
C10orf90(128335134)-ADAM12(127738238), # samples:1
Anticipated loss of major functional domain due to fusion event.C10orf90-ADAM12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C10orf90-ADAM12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C10orf90-ADAM12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C10orf90-ADAM12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C10orf90-ADAM12 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across C10orf90 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ADAM12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-D3-A1Q4-06AC10orf90chr10

128358810

-ADAM12chr10

128019078

-
ChimerDB4SKCMTCGA-ER-A3EV-06AC10orf90chr10

128335134

-ADAM12chr10

127738238

-


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Fusion Gene ORF analysis for C10orf90-ADAM12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000544758ENST00000467145C10orf90chr10

128335134

-ADAM12chr10

127738238

-
5CDS-intronENST00000544758ENST00000467145C10orf90chr10

128358810

-ADAM12chr10

128019078

-
Frame-shiftENST00000544758ENST00000368676C10orf90chr10

128358810

-ADAM12chr10

128019078

-
Frame-shiftENST00000544758ENST00000368679C10orf90chr10

128358810

-ADAM12chr10

128019078

-
In-frameENST00000544758ENST00000368676C10orf90chr10

128335134

-ADAM12chr10

127738238

-
In-frameENST00000544758ENST00000368679C10orf90chr10

128335134

-ADAM12chr10

127738238

-
intron-3CDSENST00000284694ENST00000368676C10orf90chr10

128358810

-ADAM12chr10

128019078

-
intron-3CDSENST00000284694ENST00000368676C10orf90chr10

128335134

-ADAM12chr10

127738238

-
intron-3CDSENST00000284694ENST00000368679C10orf90chr10

128358810

-ADAM12chr10

128019078

-
intron-3CDSENST00000284694ENST00000368679C10orf90chr10

128335134

-ADAM12chr10

127738238

-
intron-3CDSENST00000356858ENST00000368676C10orf90chr10

128358810

-ADAM12chr10

128019078

-
intron-3CDSENST00000356858ENST00000368676C10orf90chr10

128335134

-ADAM12chr10

127738238

-
intron-3CDSENST00000356858ENST00000368679C10orf90chr10

128358810

-ADAM12chr10

128019078

-
intron-3CDSENST00000356858ENST00000368679C10orf90chr10

128335134

-ADAM12chr10

127738238

-
intron-3CDSENST00000368674ENST00000368676C10orf90chr10

128358810

-ADAM12chr10

128019078

-
intron-3CDSENST00000368674ENST00000368676C10orf90chr10

128335134

-ADAM12chr10

127738238

-
intron-3CDSENST00000368674ENST00000368679C10orf90chr10

128358810

-ADAM12chr10

128019078

-
intron-3CDSENST00000368674ENST00000368679C10orf90chr10

128335134

-ADAM12chr10

127738238

-
intron-3CDSENST00000392694ENST00000368676C10orf90chr10

128358810

-ADAM12chr10

128019078

-
intron-3CDSENST00000392694ENST00000368676C10orf90chr10

128335134

-ADAM12chr10

127738238

-
intron-3CDSENST00000392694ENST00000368679C10orf90chr10

128358810

-ADAM12chr10

128019078

-
intron-3CDSENST00000392694ENST00000368679C10orf90chr10

128335134

-ADAM12chr10

127738238

-
intron-3CDSENST00000454341ENST00000368676C10orf90chr10

128358810

-ADAM12chr10

128019078

-
intron-3CDSENST00000454341ENST00000368676C10orf90chr10

128335134

-ADAM12chr10

127738238

-
intron-3CDSENST00000454341ENST00000368679C10orf90chr10

128358810

-ADAM12chr10

128019078

-
intron-3CDSENST00000454341ENST00000368679C10orf90chr10

128335134

-ADAM12chr10

127738238

-
intron-3CDSENST00000480379ENST00000368676C10orf90chr10

128358810

-ADAM12chr10

128019078

-
intron-3CDSENST00000480379ENST00000368676C10orf90chr10

128335134

-ADAM12chr10

127738238

-
intron-3CDSENST00000480379ENST00000368679C10orf90chr10

128358810

-ADAM12chr10

128019078

-
intron-3CDSENST00000480379ENST00000368679C10orf90chr10

128335134

-ADAM12chr10

127738238

-
intron-5UTRENST00000284694ENST00000467145C10orf90chr10

128335134

-ADAM12chr10

127738238

-
intron-5UTRENST00000356858ENST00000467145C10orf90chr10

128335134

-ADAM12chr10

127738238

-
intron-5UTRENST00000368674ENST00000467145C10orf90chr10

128335134

-ADAM12chr10

127738238

-
intron-5UTRENST00000392694ENST00000467145C10orf90chr10

128335134

-ADAM12chr10

127738238

-
intron-5UTRENST00000454341ENST00000467145C10orf90chr10

128335134

-ADAM12chr10

127738238

-
intron-5UTRENST00000480379ENST00000467145C10orf90chr10

128335134

-ADAM12chr10

127738238

-
intron-intronENST00000284694ENST00000467145C10orf90chr10

128358810

-ADAM12chr10

128019078

-
intron-intronENST00000356858ENST00000467145C10orf90chr10

128358810

-ADAM12chr10

128019078

-
intron-intronENST00000368674ENST00000467145C10orf90chr10

128358810

-ADAM12chr10

128019078

-
intron-intronENST00000392694ENST00000467145C10orf90chr10

128358810

-ADAM12chr10

128019078

-
intron-intronENST00000454341ENST00000467145C10orf90chr10

128358810

-ADAM12chr10

128019078

-
intron-intronENST00000480379ENST00000467145C10orf90chr10

128358810

-ADAM12chr10

128019078

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000544758C10orf90chr10128335134-ENST00000368679ADAM12chr10127738238-6353343211454477
ENST00000544758C10orf90chr10128335134-ENST00000368676ADAM12chr10127738238-172834321941306

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000544758ENST00000368679C10orf90chr10128335134-ADAM12chr10127738238-0.0139580940.98604196
ENST00000544758ENST00000368676C10orf90chr10128335134-ADAM12chr10127738238-0.0070175180.9929825

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Fusion Genomic Features for C10orf90-ADAM12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for C10orf90-ADAM12


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:128358810/chr10:128019078)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneADAM12chr10:128335134chr10:127738238ENST000003686761319656_688539739.0DomainEGF-like
TgeneADAM12chr10:128335134chr10:127738238ENST000003686791323656_688539910.0DomainEGF-like
TgeneADAM12chr10:128335134chr10:127738238ENST000003686761319828_834539739.0MotifSH3-binding%3B class II
TgeneADAM12chr10:128335134chr10:127738238ENST000003686761319834_841539739.0MotifSH3-binding%3B class I
TgeneADAM12chr10:128335134chr10:127738238ENST000003686761319885_891539739.0MotifSH3-binding%3B class I
TgeneADAM12chr10:128335134chr10:127738238ENST000003686791323828_834539910.0MotifSH3-binding%3B class II
TgeneADAM12chr10:128335134chr10:127738238ENST000003686791323834_841539910.0MotifSH3-binding%3B class I
TgeneADAM12chr10:128335134chr10:127738238ENST000003686791323885_891539910.0MotifSH3-binding%3B class I
TgeneADAM12chr10:128335134chr10:127738238ENST000003686761319730_909539739.0Topological domainCytoplasmic
TgeneADAM12chr10:128335134chr10:127738238ENST000003686791323730_909539910.0Topological domainCytoplasmic
TgeneADAM12chr10:128335134chr10:127738238ENST000003686761319709_729539739.0TransmembraneHelical
TgeneADAM12chr10:128335134chr10:127738238ENST000003686791323709_729539910.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC10orf90chr10:128335134chr10:127738238ENST00000284694-19663_6660700.0Compositional biasNote=Poly-Lys
HgeneC10orf90chr10:128335134chr10:127738238ENST00000454341-18663_6660603.0Compositional biasNote=Poly-Lys
HgeneC10orf90chr10:128335134chr10:127738238ENST00000480379-16663_6660104.0Compositional biasNote=Poly-Lys
HgeneC10orf90chr10:128335134chr10:127738238ENST00000284694-19571_6990700.0RegionALMS motif
HgeneC10orf90chr10:128335134chr10:127738238ENST00000454341-18571_6990603.0RegionALMS motif
HgeneC10orf90chr10:128335134chr10:127738238ENST00000480379-16571_6990104.0RegionALMS motif
TgeneADAM12chr10:128335134chr10:127738238ENST000003686761319514_649539739.0Compositional biasNote=Cys-rich
TgeneADAM12chr10:128335134chr10:127738238ENST000003686791323514_649539910.0Compositional biasNote=Cys-rich
TgeneADAM12chr10:128335134chr10:127738238ENST000003686761319214_416539739.0DomainPeptidase M12B
TgeneADAM12chr10:128335134chr10:127738238ENST000003686761319424_510539739.0DomainDisintegrin
TgeneADAM12chr10:128335134chr10:127738238ENST000003686791323214_416539910.0DomainPeptidase M12B
TgeneADAM12chr10:128335134chr10:127738238ENST000003686791323424_510539910.0DomainDisintegrin
TgeneADAM12chr10:128335134chr10:127738238ENST000003686761319177_184539739.0MotifCysteine switch
TgeneADAM12chr10:128335134chr10:127738238ENST000003686791323177_184539910.0MotifCysteine switch
TgeneADAM12chr10:128335134chr10:127738238ENST000003686761319208_708539739.0Topological domainExtracellular
TgeneADAM12chr10:128335134chr10:127738238ENST000003686791323208_708539910.0Topological domainExtracellular


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Fusion Gene Sequence for C10orf90-ADAM12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10685_10685_1_C10orf90-ADAM12_C10orf90_chr10_128335134_ENST00000544758_ADAM12_chr10_127738238_ENST00000368676_length(transcript)=1728nt_BP=343nt
ACTAGCTAAAGTCACAAGATACTGAGTCTCATGCAGCACTCTGGAATTCCTACAAAAACTCATCCGCAGGGGTATGCTGCCCGCTACACA
GAAACGGCCGTGCATCGGACTTTCCAGATAAAAACATTTAGTACAGAGTTGAAAAACCATGTGATGGTCATGGATTTTGTGAAGAGTAAC
TGGTTTCCCTCCCAGAGAAGAGCCAAAGTTTGTATCATCCATATGTGTCAAGGCTTGAAGACGGCTGAGCAGACAGCCAGCAGATATGAG
ATCCACAGTCGACTCTTCTCATCCCCCAAAGATCATTCTGCCTGGGAAAGAAATGAAAGTCTTTCCAATGCAGGTGCTAAACCTGCCCCT
GGGATCTGCTTTGAGAGAGTCAATTCTGCAGGTGATCCTTATGGCAACTGTGGCAAAGTCTCGAAGAGTTCCTTTGCCAAATGCGAGATG
AGAGATGCTAAATGTGGAAAAATCCAGTGTCAAGGAGGTGCCAGCCGGCCAGTCATTGGTACCAATGCCGTTTCCATAGAAACAAACATC
CCCCTGCAGCAAGGAGGCCGGATTCTGTGCCGGGGGACCCACGTGTACTTGGGCGATGACATGCCGGACCCAGGGCTTGTGCTTGCAGGC
ACAAAGTGTGCAGATGGAAAAATCTGCCTGAATCGTCAATGTCAAAATATTAGTGTCTTTGGGGTTCACGAGTGTGCAATGCAGTGCCAC
GGCAGAGGGGTGTGCAACAACAGGAAGAACTGCCACTGCGAGGCCCACTGGGCACCTCCCTTCTGTGACAAGTTTGGCTTTGGAGGAAGC
ACAGACAGCGGCCCCATCCGGCAAGCAGAAGCAAGGCAGGAAGCTGCAGAGTCCAACAGGGAGCGCGGCCAGGGCCAGGAGCCCGTGGGA
TCGCAGGAGCATGCGTCTACTGCCTCACTGACACTCATCTGAGCCCTCCCATGACATGGAGACCGTGACCAGTGCTGCTGCAGAGGAGGT
CACGCGTCCCCAAGGCCTCCTGTGACTGGCAGCATTGACTCTGTGGCTTTGCCATCGTTTCCATGACAACAGACACAACACAGTTCTCGG
GGCTCAGGAGGGGAAGTCCAGCCTACCAGGCACGTCTGCAGAAACAGTGCAAGGAAGGGCAGCGACTTCCTGGTTGAGCTTCTGCTAAAA
CATGGACATGCTTCAGTGCTGCTCCTGAGAGAGTAGCAGGTTACCACTCTGGCAGGCCCCAGCCCTGCAGCAAGGAGGAAGAGGACTCAA
AAGTCTGGCCTTTCACTGAGCCTCCACAGCAGTGGGGGAGAAGCAAGGGTTGGGCCCAGTGTCCCCTTTCCCCAGTGACACCTCAGCCTT
GGCAGCCCTGATGACTGGTCTCTGGCTGCAACTTAATGCTCTGATATGGCTTTTAGCATTTATTATATGAAAATAGCAGGGTTTTAGTTT
TTAATTTATCAGAGACCCTGCCACCCATTCCATCTCCATCCAAGCAAACTGAATGGCAATGAAACAAACTGGAGAAGAAGGTAGGAGAAA
GGGCGGTGAACTCTGGCTCTTTGCTGTGGACATGCGTGACCAGCAGTACTCAGGTTTGAGGGTTTGCAGAAAGCCAGGGAACCCACAGAG
TCACCAACCCTTCATTTAACAAGTAAGAATGTTAAAAAGTGAAAACAATGTAAGAGCCTAACTCCATCCCCCGTGGCCATTACTGCATAA

>10685_10685_1_C10orf90-ADAM12_C10orf90_chr10_128335134_ENST00000544758_ADAM12_chr10_127738238_ENST00000368676_length(amino acids)=306AA_BP=1
MSLMQHSGIPTKTHPQGYAARYTETAVHRTFQIKTFSTELKNHVMVMDFVKSNWFPSQRRAKVCIIHMCQGLKTAEQTASRYEIHSRLFS
SPKDHSAWERNESLSNAGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGR
ILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIR

--------------------------------------------------------------
>10685_10685_2_C10orf90-ADAM12_C10orf90_chr10_128335134_ENST00000544758_ADAM12_chr10_127738238_ENST00000368679_length(transcript)=6353nt_BP=343nt
ACTAGCTAAAGTCACAAGATACTGAGTCTCATGCAGCACTCTGGAATTCCTACAAAAACTCATCCGCAGGGGTATGCTGCCCGCTACACA
GAAACGGCCGTGCATCGGACTTTCCAGATAAAAACATTTAGTACAGAGTTGAAAAACCATGTGATGGTCATGGATTTTGTGAAGAGTAAC
TGGTTTCCCTCCCAGAGAAGAGCCAAAGTTTGTATCATCCATATGTGTCAAGGCTTGAAGACGGCTGAGCAGACAGCCAGCAGATATGAG
ATCCACAGTCGACTCTTCTCATCCCCCAAAGATCATTCTGCCTGGGAAAGAAATGAAAGTCTTTCCAATGCAGGTGCTAAACCTGCCCCT
GGGATCTGCTTTGAGAGAGTCAATTCTGCAGGTGATCCTTATGGCAACTGTGGCAAAGTCTCGAAGAGTTCCTTTGCCAAATGCGAGATG
AGAGATGCTAAATGTGGAAAAATCCAGTGTCAAGGAGGTGCCAGCCGGCCAGTCATTGGTACCAATGCCGTTTCCATAGAAACAAACATC
CCCCTGCAGCAAGGAGGCCGGATTCTGTGCCGGGGGACCCACGTGTACTTGGGCGATGACATGCCGGACCCAGGGCTTGTGCTTGCAGGC
ACAAAGTGTGCAGATGGAAAAATCTGCCTGAATCGTCAATGTCAAAATATTAGTGTCTTTGGGGTTCACGAGTGTGCAATGCAGTGCCAC
GGCAGAGGGGTGTGCAACAACAGGAAGAACTGCCACTGCGAGGCCCACTGGGCACCTCCCTTCTGTGACAAGTTTGGCTTTGGAGGAAGC
ACAGACAGCGGCCCCATCCGGCAAGCAGATAACCAAGGTTTAACCATAGGAATTCTGGTGACCATCCTGTGTCTTCTTGCTGCCGGATTT
GTGGTTTATCTCAAAAGGAAGACCTTGATACGACTGCTGTTTACAAATAAGAAGACCACCATTGAAAAACTAAGGTGTGTGCGCCCTTCC
CGGCCACCCCGTGGCTTCCAACCCTGTCAGGCTCACCTCGGCCACCTTGGAAAAGGCCTGATGAGGAAGCCGCCAGATTCCTACCCACCG
AAGGACAATCCCAGGAGATTGCTGCAGTGTCAGAATGTTGACATCAGCAGACCCCTCAACGGCCTGAATGTCCCTCAGCCCCAGTCAACT
CAGCGAGTGCTTCCTCCCCTCCACCGGGCTCCACGTGCACCTAGCGTCCCTGCCAGACCCCTGCCAGCCAAGCCTGCACTTAGGCAGGCC
CAGGGGACCTGTAAGCCAAACCCCCCTCAGAAGCCTCTGCCTGCAGATCCTCTGGCCAGAACAACTCGGCTCACTCATGCCTTGGCCAGG
ACCCCAGGACAATGGGAGACTGGGCTCCGCCTGGCACCCCTCAGACCTGCTCCACAATATCCACACCAAGTGCCCAGATCCACCCACACC
GCCTATATTAAGTGAGAAGCCGACACCTTTTTTCAACAGTGAAGACAGAAGTTTGCACTATCTTTCAGCTCCAGTTGGAGTTTTTTGTAC
CAACTTTTAGGATTTTTTTTAATGTTTAAAACATCATTACTATAAGAACTTTGAGCTACTGCCGTCAGTGCTGTGCTGTGCTATGGTGCT
CTGTCTACTTGCTCAGGTACTTGTAAATTATTAATTTATGCAGAATGTTGATTACAGTGCAGTGCGCTGTAGTAGGCATTTTTACCATCA
CTGAGTTTTCCATGGCAGGAAGGCTTGTTGTGCTTTTAGTATTTTAGTGAACTTGAAATATCCTGCTTGATGGGATTCTGGACAGGATGT
GTTTGCTTTCTGATCAAGGCCTTATTGGAAAGCAGTCCCCCAACTACCCCCAGCTGTGCTTATGGTACCAGATGCAGCTCAAGAGATCCC
AAGTAGAATCTCAGTTGATTTTCTGGATTCCCCATCTCAGGCCAGAGCCAAGGGGCTTCAGGTCCAGGCTGTGTTTGGCTTTCAGGGAGG
CCCTGTGCCCCTTGACAACTGGCAGGCAGGCTCCCAGGGACACCTGGGAGAAATCTGGCTTCTGGCCAGGAAGCTTTGGTGAGAACCTGG
GTTGCAGACAGGAATCTTAAGGTGTAGCCACACCAGGATAGAGACTGGAACACTAGACAAGCCAGAACTTGACCCTGAGCTGACCAGCCG
TGAGCATGTTTGGAAGGGGTCTGTAGTGTCACTCAAGGCGGTGCTTGATAGAAATGCCAAGCACTTCTTTTTCTCGCTGTCCTTTCTAGA
GCACTGCCACCAGTAGGTTATTTAGCTTGGGAAAGGTGGTGTTTCTGTAAGAAACCTACTGCCCAGGCACTGCAAACCGCCACCTCCCTA
TACTGCTTGGAGCTGAGCAAATCACCACAAACTGTAATACAATGATCCTGTATTCAGACAGATGAGGCTTTCCATGGGACCACAACTATT
TTCAGATGTGAACCATTAACCAGATCTAGTCAATCAAGTCTGTTTACTGCAAGGTTCAACTTATTAACAATTAGGCAGACTCTTTATGCT
TGCAAAAACTACAACCAATGGAATGTGATGTTCATGGGTATAGTTCATGTCTGCTATCATTATTCGTAGATATTGGACAAAGAACCTTCT
CTATGGGGCATCCTCTTTTTCCAACTTGGCTGCAGGAATCTTTAAAAGATGCTTTTAACAGAGTCTGAACCTATTTCTTAAACACTTGCA
ACCTACCTGTTGAGCATCACAGAATGTGATAAGGAAATCAACTTGCTTATCAACTTCCTAAATATTATGAGATGCTGGCTTGGGCAGCAT
CCCCTTGAACTCTTCACTCTTCAAATGCCTGACTAGGGAGCCATGTTTCACAAGGTCTTTAAAGTGACTAATGGCATGAGAAATACAAAA
ATACTCAGATAAGGTAAAATGCCATGATGCCTCTGTCTTCTGGACTGGTTTTCACATTAGAAGACAATTGACAACAGTTACATAATTCAC
TCTGAGTGTTTTATGAGAAAGCCTTCTTTTGGGGGTCAACAGTTTTCCTATGCTTTGAAACAGAAAAATATGTACCAAGAATCTTGGTTT
GCCTTCCAGAAAACAAAACTGCATTTCACTTTCCCGGTGTTCCCCACTGTATCTAGGCAACATAGTATTCATGACTATGGATAAACTAAA
CACGTGACACAAACACACACAAAAGGGAACCCAGCTCTAATACATTCCAACTCGTATAGCATGCATCTGTTTATTCTATAGTTATTAAGT
TCTTTAAAATGTAAAGCCATGCTGGAAAATAATACTGCTGAGATACATACAGAATTACTGTAACTGATTACACTTGGTAATTGTACTAAA
GCCAAACATATATATACTATTAAAAAGGTTTACAGAATTTTATGGTGCATTACGTGGGCATTGTCTTTTTAGATGCCCAAATCCTTAGAT
CTGGCATGTTAGCCCTTCCTCCAATTATAAGAGGATATGAACTGAGTTTTTCTTTTGTTGTTTGTTCTTAGCTGTAATTCCTATGCTTCT
ATTTCAGAGAGCCAGGAGAGTTTGATATTAAAGGAGGTTAAAACTGTGATCTTATGCCATGTCATCAATGGCCACTTAGGGGCCATGGCT
GATGACACATTCTTATCTCTACAGTACTAATGTGTTATTATAGAGCCATGCATTTTATTTCTGAATAAGAACATATTTAAACTAATATTC
CCTTACAATATGGACAGTATTAATCCTTCCAAGATGCAGTATTTATCAAGTGAAGCATATTTAGCAGCAAATTCCATTTTAACATAACTT
AGGAACCAATAACCAGGGTGTTTTGTGGTTGGGGGAGGCACGGGGTGGAGTATTCTTTTTTATATCCTCAAAACAAAAAAAATCAATACT
TATATTTCAATGGCAATCTAGTATTTTTTTAAAAGACTGTATAGGCATGAATAATAGAGGTGGTTTGAGTTTTGTAGGGCCATCACCTGG
AAAGTCAATGTGACTAGACACAAAGTAGCCCAGAGGCTACTTTTCTTCCTACAGCTTATTATAGTTGTAGGTTCTATGACCTCACTTCAT
GGGTTCCAGGCAATTCCGCTGAAAGGTTTGTCTCCTGAAATTTTTTAAGTTTGTTTTCCTGACACATGTAATCAGATGTGTAGCAACCGA
GGGAAACGAAGCCTAACATTCTCCATTGTGGAAATACACACAGGAGGTTACATTTCACAGCGTGGATTTTTCCAGCTTACACATGTGGGA
TGACATCACAGAAACCACAAAAGCAGCAAATTAAACTGTAGGAGAGTCAATACTCCTGACGAGTCTCGGGGGGGGGGCATTTTTATGCCT
TCTTAACTTTATGAGAATTCTCAGGCTGAACTATAGGCCATTGTTCCCAGGCAAATCAATACATCAATGCATCCTCAAAAAAAAAAAAAA
AAAAAAAAAACCGGCTAAAACTGTGTCAAAATGTTCTTAAGGAGCCTATGGTCTCCACGGTGCTAAAAAGAGCCTGGTGCTGGGCCGACT
GGCAGGGCTGAGCATCCTCCTGCCCCCTCGCCACTGATGTTTACTAAGCACTCTGAGCCAATGAGACCCCCAGCAGCAGAAAGGGCACAA
GGTGGCGCCAGGGCAGCAGGGCCAGATCTTTCTCATGCACCTCGACCTCTTGCAGACTTTCTTCGTGAGATGTACTACTCATTTCAAAAC
TGCTTTGCAGGGCTCCCCTATGTATTCGGGGGGCCCACGGCACACTCAGGCTGGAGATCCTTCCTCACTGCGCTCAAGATGGCCTCAGCC
AGACACCAGTTACCCAGCTGAAAGTCACAATCCCTCCCAGAAGTCTCCCAACACTAGTGCTGACCAGAGGTGGGGCTCTCAGGCTAGGAG
TTTCACACACAATGACAGGCTGCTGGGGGACATTGCAGGACCCCTTTTCCTCTCCTCTCCATGCTAGAAGCCAGCCCTAGGCAGCTGCAG
TTACTCCCTGTGACTCAGCAGCAGGCTGATTCAACACAGCTGCCCACACAAAGCCAGTGGCTAATACATCTGTTTACCTTTCCCTATCAC
CCAGACACAAGCCCCTTTCCCAGGTCAAACCACAGGCCGATGCATCTCCAGTTTGACAGTCAAATCACTACTTCCATTGCTACTTTAGAT
CAGCCAAAGTGGTGACTGCTGCAGTGTGTGGCTATCCCTACAAGGCCCACCCAAGGGATGCCCAAAGCCCAACCTTCTCCAGGGCTGCAG
CCCAGAGCAACCCCACCAGCCTAAGTCCAGCAGAGGACCTCCCACCCAATGTCTTGTTCTAATTAGAAGGGGAAGTTAGCCACAGAAAAT
CAACTTATCTATAATTACAAAATTCTCTTGACTCACCTTAAAGTTCCTATTGACATCTACTGCTTTTAAACCTATTTGAAAACTCTGATA
CTAAAACAAATGACACTCTAAGAAAGTTTGGGAGCCCCATGCTGAGAACCATTTCTGTGCAGTGAGGATGTTTCCAGAAGCTACTTACCT
ACATGTGAATGTGCCATTTTCTTTCCTTTTGTAGAGAAAATCCCCTTTACTTTTTGGAACAGTAATGGCAGCTTCTAGTACAGCCATTAC
AGTTTCATATGAGAAAAATTAAGAATAACTATAAAATTGTTAAAATATCCAATAATGGATAATGATGGCCAGAAGATTTAACATACAAAG
TAATTCTCAATGTAAAGCTATTCAGCTCTTCCAGGTTGAATGCCCTGTAACCCACCCTGACCTTCCACATCATCTTCAAAAAGCAGTTTC
TCTGTTCCCCATGATTCTCCTATAAGGTAACTCTTTAGTCCTCCATTTAGCACATTTTAAATCCTCCAAAGAATAAGTATCATGTGATTA
TTTTAGCTTTACAAAAAAAAAGTTGAATGGCGTTTTATTTTCATGGCCTATAAGCAGGTACCTTAGTAGGGCAGATATAGGAAAAACAAA
TTAGAGCAAAACAAATCCTCTACAAATCCAAGGCAGGAAAAGTGGTGGCAGAGTGACTCATTCTCCTGTCCCTCCCATCAGGTCAAATCA
GGAGGCTGCAGTGAATGCCTGTTCTTTGAATGTGTAGCAGTTGTTCCTGTAACTCTTTAAAACTTGGCTATAGGCTGTTTAGCACAGTAC
AGATTAAAGATACAGTTACGTAAACAGCAAAGTAATTTTATAGTGCTTCATCCATTTATCATGCTTTGGTTTGCTAATTTTTTCACATAC
CTTTTTCTATCACAGTCTGTTGCTTTTGTACACATTTCTCATATTGGGGTTCGACAGGTAAACACAAACTGCTATTTCAGTAGAAAAAGT

>10685_10685_2_C10orf90-ADAM12_C10orf90_chr10_128335134_ENST00000544758_ADAM12_chr10_127738238_ENST00000368679_length(amino acids)=477AA_BP=1
MSLMQHSGIPTKTHPQGYAARYTETAVHRTFQIKTFSTELKNHVMVMDFVKSNWFPSQRRAKVCIIHMCQGLKTAEQTASRYEIHSRLFS
SPKDHSAWERNESLSNAGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGR
ILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIR
QADNQGLTIGILVTILCLLAAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPKDNPRRL
LQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALRQAQGTCKPNPPQKPLPADPLARTTRLTHALARTPGQWET

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Fusion Gene PPI Analysis for C10orf90-ADAM12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C10orf90-ADAM12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C10orf90-ADAM12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0036341Schizophrenia1PSYGENET