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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKRD22-LRRTM3 (FusionGDB2 ID:HG118932TG347731)

Fusion Gene Summary for ANKRD22-LRRTM3

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD22-LRRTM3
Fusion gene ID: hg118932tg347731
HgeneTgene
Gene symbol

ANKRD22

LRRTM3

Gene ID

118932

347731

Gene nameankyrin repeat domain 22leucine rich repeat transmembrane neuronal 3
Synonyms--
Cytomap('ANKRD22')('LRRTM3')

10q23.31

10q21.3

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 22leucine-rich repeat transmembrane neuronal protein 3
Modification date2020031320200313
UniProtAcc

Q5VYY1

.
Ensembl transtripts involved in fusion geneENST00000371930, ENST00000476963, 
Fusion gene scores* DoF score2 X 4 X 1=84 X 3 X 4=48
# samples 46
** MAII scorelog2(4/8*10)=2.32192809488736log2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ANKRD22 [Title/Abstract] AND LRRTM3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKRD22(90611344)-LRRTM3(68857345), # samples:3
Anticipated loss of major functional domain due to fusion event.ANKRD22-LRRTM3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD22-LRRTM3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLRRTM3

GO:0099054

presynapse assembly

26776509


check buttonFusion gene breakpoints across ANKRD22 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across LRRTM3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-XQ-A8TB-01AANKRD22chr10

90611344

-LRRTM3chr10

68857345

+
ChimerDB4PRADTCGA-XQ-A8TBANKRD22chr10

90611343

-LRRTM3chr10

68857344

+
ChimerDB4PRADTCGA-XQ-A8TBANKRD22chr10

90611344

-LRRTM3chr10

68857345

+


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Fusion Gene ORF analysis for ANKRD22-LRRTM3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000371930ENST00000485868ANKRD22chr10

90611344

-LRRTM3chr10

68857345

+
5CDS-3UTRENST00000371930ENST00000485868ANKRD22chr10

90611343

-LRRTM3chr10

68857344

+
In-frameENST00000371930ENST00000361320ANKRD22chr10

90611344

-LRRTM3chr10

68857345

+
In-frameENST00000371930ENST00000361320ANKRD22chr10

90611343

-LRRTM3chr10

68857344

+
intron-3CDSENST00000476963ENST00000361320ANKRD22chr10

90611344

-LRRTM3chr10

68857345

+
intron-3CDSENST00000476963ENST00000361320ANKRD22chr10

90611343

-LRRTM3chr10

68857344

+
intron-3UTRENST00000476963ENST00000485868ANKRD22chr10

90611344

-LRRTM3chr10

68857345

+
intron-3UTRENST00000476963ENST00000485868ANKRD22chr10

90611343

-LRRTM3chr10

68857344

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000371930ANKRD22chr1090611344-ENST00000361320LRRTM3chr1068857345+247623239412290
ENST00000371930ANKRD22chr1090611343-ENST00000361320LRRTM3chr1068857344+247623239412290

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371930ENST00000361320ANKRD22chr1090611344-LRRTM3chr1068857345+0.79281990.20718008
ENST00000371930ENST00000361320ANKRD22chr1090611343-LRRTM3chr1068857344+0.79281990.20718008

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Fusion Genomic Features for ANKRD22-LRRTM3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ANKRD22chr1090611343-LRRTM3chr1068857344+0.0008673510.9991327
ANKRD22chr1090611343-LRRTM3chr1068857344+0.0008673510.9991327
ANKRD22chr1090611343-LRRTM3chr1068857344+0.0008673510.9991327
ANKRD22chr1090611343-LRRTM3chr1068857344+0.0008673510.9991327

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ANKRD22-LRRTM3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:90611344/chr10:68857345)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD22

Q5VYY1

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD22chr10:90611343chr10:68857344ENST00000371930-16101_1307192.0RepeatNote=ANK 3
HgeneANKRD22chr10:90611343chr10:68857344ENST00000371930-16134_1637192.0RepeatNote=ANK 4
HgeneANKRD22chr10:90611343chr10:68857344ENST00000371930-1639_687192.0RepeatNote=ANK 1
HgeneANKRD22chr10:90611343chr10:68857344ENST00000371930-1672_1007192.0RepeatNote=ANK 2
HgeneANKRD22chr10:90611344chr10:68857345ENST00000371930-16101_1307192.0RepeatNote=ANK 3
HgeneANKRD22chr10:90611344chr10:68857345ENST00000371930-16134_1637192.0RepeatNote=ANK 4
HgeneANKRD22chr10:90611344chr10:68857345ENST00000371930-1639_687192.0RepeatNote=ANK 1
HgeneANKRD22chr10:90611344chr10:68857345ENST00000371930-1672_1007192.0RepeatNote=ANK 2
TgeneLRRTM3chr10:90611343chr10:68857344ENST0000036132013312_363512582.0DomainNote=LRRCT
TgeneLRRTM3chr10:90611343chr10:68857344ENST000003613201331_61512582.0DomainNote=LRRNT
TgeneLRRTM3chr10:90611344chr10:68857345ENST0000036132013312_363512582.0DomainNote=LRRCT
TgeneLRRTM3chr10:90611344chr10:68857345ENST000003613201331_61512582.0DomainNote=LRRNT
TgeneLRRTM3chr10:90611343chr10:68857344ENST0000036132013110_131512582.0RepeatNote=LRR 3
TgeneLRRTM3chr10:90611343chr10:68857344ENST0000036132013134_155512582.0RepeatNote=LRR 4
TgeneLRRTM3chr10:90611343chr10:68857344ENST0000036132013158_179512582.0RepeatNote=LRR 5
TgeneLRRTM3chr10:90611343chr10:68857344ENST0000036132013182_203512582.0RepeatNote=LRR 6
TgeneLRRTM3chr10:90611343chr10:68857344ENST0000036132013206_226512582.0RepeatNote=LRR 7
TgeneLRRTM3chr10:90611343chr10:68857344ENST0000036132013230_251512582.0RepeatNote=LRR 8
TgeneLRRTM3chr10:90611343chr10:68857344ENST0000036132013254_275512582.0RepeatNote=LRR 9
TgeneLRRTM3chr10:90611343chr10:68857344ENST0000036132013279_300512582.0RepeatNote=LRR 10
TgeneLRRTM3chr10:90611343chr10:68857344ENST000003613201363_83512582.0RepeatNote=LRR 1
TgeneLRRTM3chr10:90611343chr10:68857344ENST000003613201386_107512582.0RepeatNote=LRR 2
TgeneLRRTM3chr10:90611344chr10:68857345ENST0000036132013110_131512582.0RepeatNote=LRR 3
TgeneLRRTM3chr10:90611344chr10:68857345ENST0000036132013134_155512582.0RepeatNote=LRR 4
TgeneLRRTM3chr10:90611344chr10:68857345ENST0000036132013158_179512582.0RepeatNote=LRR 5
TgeneLRRTM3chr10:90611344chr10:68857345ENST0000036132013182_203512582.0RepeatNote=LRR 6
TgeneLRRTM3chr10:90611344chr10:68857345ENST0000036132013206_226512582.0RepeatNote=LRR 7
TgeneLRRTM3chr10:90611344chr10:68857345ENST0000036132013230_251512582.0RepeatNote=LRR 8
TgeneLRRTM3chr10:90611344chr10:68857345ENST0000036132013254_275512582.0RepeatNote=LRR 9
TgeneLRRTM3chr10:90611344chr10:68857345ENST0000036132013279_300512582.0RepeatNote=LRR 10
TgeneLRRTM3chr10:90611344chr10:68857345ENST000003613201363_83512582.0RepeatNote=LRR 1
TgeneLRRTM3chr10:90611344chr10:68857345ENST000003613201386_107512582.0RepeatNote=LRR 2
TgeneLRRTM3chr10:90611343chr10:68857344ENST000003613201331_419512582.0Topological domainExtracellular
TgeneLRRTM3chr10:90611343chr10:68857344ENST0000036132013441_581512582.0Topological domainCytoplasmic
TgeneLRRTM3chr10:90611344chr10:68857345ENST000003613201331_419512582.0Topological domainExtracellular
TgeneLRRTM3chr10:90611344chr10:68857345ENST0000036132013441_581512582.0Topological domainCytoplasmic
TgeneLRRTM3chr10:90611343chr10:68857344ENST0000036132013420_440512582.0TransmembraneHelical
TgeneLRRTM3chr10:90611344chr10:68857345ENST0000036132013420_440512582.0TransmembraneHelical


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Fusion Gene Sequence for ANKRD22-LRRTM3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4630_4630_1_ANKRD22-LRRTM3_ANKRD22_chr10_90611343_ENST00000371930_LRRTM3_chr10_68857344_ENST00000361320_length(transcript)=2476nt_BP=232nt
ATTGGGCTGGGCTCTCTGGAAGGTGTGCTGCTGCCTGAGCTGCTGGAAAAGCACTGACAGGTGTTTGCTAGAAAAGCACTCCTGGAGCTT
GCCACCAGCTTGGACTTCTAGGGACTTTCCTCTCAGCCAGGAAGGATTTTGATATTCATCAGAAATACCTCCAGAAGATTCAAGGAGCTG
TAGAGGTGAAGTAAGCCTGTGAAGGACCAGCATGGGAATCCTATACTCTGAGATACCTTTATCAATGAATGTGTCAACCTTTCTGGCATA
CGACCAGCCCACAATAAGTTACTGTGGGGTGCATCATGAACTTCTCTCCCATAAGTCCTTTGAAACGAATGCACAGGAAGATACGATGGA
AACACACCTAGAGACTGAGCTGGACCTGAGCACAATCACAACAGCTGGCCGAATCAGTGACCATAAACAGCAGCTAGCTTAACTGAGATC
ATTGGTAGCCAGGGGTTGCTACCAAACTTTGTAACCTCAAGGACAAAATGAGGAAGATGTGTTCATTGTGGACTCTAAAAACAAAACAAA
ACACAAAATCCCCTGTTCAAATAAACAAAAAATCCAAGATTGATTCATGAAATAAAGAAGACATGAATTGTTTTAAGTCTACACTTTGTA
ATTAGCTAAGTTGTGCAGTATTTTTTGACTTAAACAGAGTATGACCCTGAAAAATAAAAGAATCTTTTTTTTTCAAAACTCATCCTACCT
ACCTGTAAAAACTGTACAAAGCTAATGTATTTTTCATATTGTAAAGTTTCAATTGTAGAAACAACTGGTATGTACAGTACCATAATTTAA
TTACATTTTACTTTAAAAACTTTACACATTTCAGTTTCTAAAATTTTAAATTAACAAAAATTATTTCTTGTGTTATTCAGAGTTACTCAG
TTTTGTAAGGACTGTTTTGTTACTGCTTTTGTGCCCAGAAACCTTGACTCTAAAATTCTGTGCTGTGCGAAACATGCACGATTTTTATTA
TGCTTACTGCGTAGAATTTTATCTACTTGTTCCAGAAATAATACATTAACCAAAAAGGATTTAATTGTTCAGACTTGTAAGAGGTTCTTC
AATTACATAGGCAGGTTTTTCTTAAAAATGAAAAAAAAATCAAAGATTTTTTTAACAGTTCTCAGACTTAACTGTTGCCTTGAATTACAG
CCTAGTTTCTAAGCAGTGAAATGTAATGATAAAGAGGGATATTTTAACATATTTCCGAATGAATGACTCATTATTTCATTCTTTTGAGTA
ACCATTGTTAAGGGTTGGGGGAAAGCATGGACAAAACATCACTGGAAACAAAGGCTGTAACCACAGCAACAGACTTTGTGATACAGTTAA
AAGGTGCAGCTGCCAGTGACAAATAAAAACTTTTGTTACATCTCATTATTTTCAGGCCAAGGTGGGAGTATAGTGCATAATAATTGTACA
GTAGCAATTTTTATCCTAATTAACCCATAGCGGTTTACCTAAAAGTAACCATCAGTCAGTGCAAAATGTGCCTGGTTCTTAAGACAACTT
TTTATTTAGAACTGTGAGACCGGTATTTTGGAAACATTTCAAAGGAAACATATGAATTTGTTTTGCGTTGTGCACTACATCATTTCTCTC
CTGAGGAAGAATTTTAAACATGTACAGCTCATTCAATATAGATATGAGCCATGGTGGAGAACTTTATCACTCAAGTAGACGGTAAACATC
CTTAATATGTTCTAAATTGTTTATATTGCTATCCATAATGGGATTCACCTCCAAATTATCAAAGAAATAACTCAGAGTAATTTGACACCA
GCCCAGATCATATATTGATTATACAATTGTATTATAAAGTTCATTCAAATCAAATTAAGAAAACCTGAGTCTTTAGAAGCTGAAATAATC
AACTTGTTTGTGCTGTTTGCTTGACATAGGTTATTGTTTGAAAATATTGTTACTTTATCAATAGTAATCATGCATTCTTGTGTTTTTTTT
TAATGGAAAACTGCAAGTTTCAATTACTGTTGCACTAGAAGTGCTTTTTATGTTGTCATTTTATATTCATGCCATCAAAAGTAGATTGAC
AATACATCAATCTAACAGGGGCCAATCAAAACAATGAAGAAAAGAATAACTGAAAACAATGTCAAACTTTTAAATTTTTATCTCTTCCAA
AGAAGTTATATCTATAAAATCTAGTTTTATGCAGGTTTGTCACAGCAAATGTAAAAGCGGATTCAAGAAGAATGAACTTAAAAACTGTGG
AGCAAATTTTTGTTGAAAATATATAAAGTCAGAAAGAAAAAAGATGTAAATGTTGGAAGAAGCAAATTCTATTACTAATTCAAATGAAAC
TAAATGTCAAACACAGTACTTGTGTCAACTATTTAGCATCCCAGATTTTGTAACATATTTTGCATAAATTATTTGCTCTTCAAAAATTTT

>4630_4630_1_ANKRD22-LRRTM3_ANKRD22_chr10_90611343_ENST00000371930_LRRTM3_chr10_68857344_ENST00000361320_length(amino acids)=90AA_BP=1
MCSGPAQSLGVFPSYLPVHSFQRTYGREVHDAPHSNLLWAGRMPERLTHSLIKVSQSIGFPCWSFTGLLHLYSSLNLLEVFLMNIKILPG

--------------------------------------------------------------
>4630_4630_2_ANKRD22-LRRTM3_ANKRD22_chr10_90611344_ENST00000371930_LRRTM3_chr10_68857345_ENST00000361320_length(transcript)=2476nt_BP=232nt
ATTGGGCTGGGCTCTCTGGAAGGTGTGCTGCTGCCTGAGCTGCTGGAAAAGCACTGACAGGTGTTTGCTAGAAAAGCACTCCTGGAGCTT
GCCACCAGCTTGGACTTCTAGGGACTTTCCTCTCAGCCAGGAAGGATTTTGATATTCATCAGAAATACCTCCAGAAGATTCAAGGAGCTG
TAGAGGTGAAGTAAGCCTGTGAAGGACCAGCATGGGAATCCTATACTCTGAGATACCTTTATCAATGAATGTGTCAACCTTTCTGGCATA
CGACCAGCCCACAATAAGTTACTGTGGGGTGCATCATGAACTTCTCTCCCATAAGTCCTTTGAAACGAATGCACAGGAAGATACGATGGA
AACACACCTAGAGACTGAGCTGGACCTGAGCACAATCACAACAGCTGGCCGAATCAGTGACCATAAACAGCAGCTAGCTTAACTGAGATC
ATTGGTAGCCAGGGGTTGCTACCAAACTTTGTAACCTCAAGGACAAAATGAGGAAGATGTGTTCATTGTGGACTCTAAAAACAAAACAAA
ACACAAAATCCCCTGTTCAAATAAACAAAAAATCCAAGATTGATTCATGAAATAAAGAAGACATGAATTGTTTTAAGTCTACACTTTGTA
ATTAGCTAAGTTGTGCAGTATTTTTTGACTTAAACAGAGTATGACCCTGAAAAATAAAAGAATCTTTTTTTTTCAAAACTCATCCTACCT
ACCTGTAAAAACTGTACAAAGCTAATGTATTTTTCATATTGTAAAGTTTCAATTGTAGAAACAACTGGTATGTACAGTACCATAATTTAA
TTACATTTTACTTTAAAAACTTTACACATTTCAGTTTCTAAAATTTTAAATTAACAAAAATTATTTCTTGTGTTATTCAGAGTTACTCAG
TTTTGTAAGGACTGTTTTGTTACTGCTTTTGTGCCCAGAAACCTTGACTCTAAAATTCTGTGCTGTGCGAAACATGCACGATTTTTATTA
TGCTTACTGCGTAGAATTTTATCTACTTGTTCCAGAAATAATACATTAACCAAAAAGGATTTAATTGTTCAGACTTGTAAGAGGTTCTTC
AATTACATAGGCAGGTTTTTCTTAAAAATGAAAAAAAAATCAAAGATTTTTTTAACAGTTCTCAGACTTAACTGTTGCCTTGAATTACAG
CCTAGTTTCTAAGCAGTGAAATGTAATGATAAAGAGGGATATTTTAACATATTTCCGAATGAATGACTCATTATTTCATTCTTTTGAGTA
ACCATTGTTAAGGGTTGGGGGAAAGCATGGACAAAACATCACTGGAAACAAAGGCTGTAACCACAGCAACAGACTTTGTGATACAGTTAA
AAGGTGCAGCTGCCAGTGACAAATAAAAACTTTTGTTACATCTCATTATTTTCAGGCCAAGGTGGGAGTATAGTGCATAATAATTGTACA
GTAGCAATTTTTATCCTAATTAACCCATAGCGGTTTACCTAAAAGTAACCATCAGTCAGTGCAAAATGTGCCTGGTTCTTAAGACAACTT
TTTATTTAGAACTGTGAGACCGGTATTTTGGAAACATTTCAAAGGAAACATATGAATTTGTTTTGCGTTGTGCACTACATCATTTCTCTC
CTGAGGAAGAATTTTAAACATGTACAGCTCATTCAATATAGATATGAGCCATGGTGGAGAACTTTATCACTCAAGTAGACGGTAAACATC
CTTAATATGTTCTAAATTGTTTATATTGCTATCCATAATGGGATTCACCTCCAAATTATCAAAGAAATAACTCAGAGTAATTTGACACCA
GCCCAGATCATATATTGATTATACAATTGTATTATAAAGTTCATTCAAATCAAATTAAGAAAACCTGAGTCTTTAGAAGCTGAAATAATC
AACTTGTTTGTGCTGTTTGCTTGACATAGGTTATTGTTTGAAAATATTGTTACTTTATCAATAGTAATCATGCATTCTTGTGTTTTTTTT
TAATGGAAAACTGCAAGTTTCAATTACTGTTGCACTAGAAGTGCTTTTTATGTTGTCATTTTATATTCATGCCATCAAAAGTAGATTGAC
AATACATCAATCTAACAGGGGCCAATCAAAACAATGAAGAAAAGAATAACTGAAAACAATGTCAAACTTTTAAATTTTTATCTCTTCCAA
AGAAGTTATATCTATAAAATCTAGTTTTATGCAGGTTTGTCACAGCAAATGTAAAAGCGGATTCAAGAAGAATGAACTTAAAAACTGTGG
AGCAAATTTTTGTTGAAAATATATAAAGTCAGAAAGAAAAAAGATGTAAATGTTGGAAGAAGCAAATTCTATTACTAATTCAAATGAAAC
TAAATGTCAAACACAGTACTTGTGTCAACTATTTAGCATCCCAGATTTTGTAACATATTTTGCATAAATTATTTGCTCTTCAAAAATTTT

>4630_4630_2_ANKRD22-LRRTM3_ANKRD22_chr10_90611344_ENST00000371930_LRRTM3_chr10_68857345_ENST00000361320_length(amino acids)=90AA_BP=1
MCSGPAQSLGVFPSYLPVHSFQRTYGREVHDAPHSNLLWAGRMPERLTHSLIKVSQSIGFPCWSFTGLLHLYSSLNLLEVFLMNIKILPG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ANKRD22-LRRTM3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKRD22-LRRTM3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKRD22-LRRTM3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC1510586Autism Spectrum Disorders1CTD_human