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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CLK3-ZSWIM7 (FusionGDB2 ID:HG1198TG125150)

Fusion Gene Summary for CLK3-ZSWIM7

check button Fusion gene summary
Fusion gene informationFusion gene name: CLK3-ZSWIM7
Fusion gene ID: hg1198tg125150
HgeneTgene
Gene symbol

CLK3

ZSWIM7

Gene ID

1198

125150

Gene nameCDC like kinase 3zinc finger SWIM-type containing 7
SynonymsPHCLK3|PHCLK3/152SWS1
Cytomap('CLK3')('ZSWIM7')

15q24.1

17p12

Type of geneprotein-codingprotein-coding
Descriptiondual specificity protein kinase CLK3zinc finger SWIM domain-containing protein 7SWIM domain-containing and Srs2-interacting protein 1 homologSWIM-type zinc finger domain-containing protein 7
Modification date2020031320200320
UniProtAcc

P49761

.
Ensembl transtripts involved in fusion geneENST00000348245, ENST00000345005, 
ENST00000352989, ENST00000395066, 
ENST00000564353, 
Fusion gene scores* DoF score6 X 6 X 4=1444 X 3 X 4=48
# samples 64
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLK3 [Title/Abstract] AND ZSWIM7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCLK3(74917357)-ZSWIM7(15881382), # samples:1
Anticipated loss of major functional domain due to fusion event.CLK3-ZSWIM7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CLK3-ZSWIM7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CLK3-ZSWIM7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CLK3-ZSWIM7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLK3

GO:0006468

protein phosphorylation

9637771

HgeneCLK3

GO:0043484

regulation of RNA splicing

9637771


check buttonFusion gene breakpoints across CLK3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ZSWIM7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for CLK3-ZSWIM7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000345005ENST00000399277CLK3chr1574917357+ZSWIM7chr1715881382-0.0279264450.97207355
ENST00000395066ENST00000399277CLK3chr1574917357+ZSWIM7chr1715881382-0.14956210.8504379
ENST00000352989ENST00000399277CLK3chr1574917357+ZSWIM7chr1715881382-0.040467170.9595328

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Fusion Genomic Features for CLK3-ZSWIM7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CLK3-ZSWIM7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:74917357/chr17:15881382)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLK3

P49761

.
FUNCTION: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:9637771}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLK3chr15:74917357chr17:15881382ENST00000395066+613167_264364639.0Compositional biasNote=Arg-rich
HgeneCLK3chr15:74917357chr17:15881382ENST00000395066+613310_318364639.0Nucleotide bindingATP
TgeneZSWIM7chr15:74917357chr17:15881382ENST000003992770566_1140141.0Zinc fingerSWIM-type
TgeneZSWIM7chr15:74917357chr17:15881382ENST000004724950666_1140180.66666666666666Zinc fingerSWIM-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLK3chr15:74917357chr17:15881382ENST00000345005+613167_264216491.0Compositional biasNote=Arg-rich
HgeneCLK3chr15:74917357chr17:15881382ENST00000348245+512167_264184225.0Compositional biasNote=Arg-rich
HgeneCLK3chr15:74917357chr17:15881382ENST00000345005+613304_620216491.0DomainProtein kinase
HgeneCLK3chr15:74917357chr17:15881382ENST00000348245+512304_620184225.0DomainProtein kinase
HgeneCLK3chr15:74917357chr17:15881382ENST00000395066+613304_620364639.0DomainProtein kinase
HgeneCLK3chr15:74917357chr17:15881382ENST00000345005+613310_318216491.0Nucleotide bindingATP
HgeneCLK3chr15:74917357chr17:15881382ENST00000348245+512310_318184225.0Nucleotide bindingATP


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Fusion Gene Sequence for CLK3-ZSWIM7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>17213_17213_1_CLK3-ZSWIM7_CLK3_chr15_74917357_ENST00000345005_ZSWIM7_chr17_15881382_ENST00000399277_length(transcript)=2214nt_BP=705nt
GGGGCACTGGTACCTCCAGGACCTGGAGTGTACTGGAAGAAATGGTGCAGTCCAGATGCATCACTGTAAGCGATACCGCTCCCCTGAACC
AGACCCGTACCTGAGCTACCGATGGAAGAGGAGGAGGTCCTACAGTCGGGAACATGAAGGGAGACTGCGATACCCGTCCCGAAGGGAGCC
TCCCCCACGAAGATCTCGGTCCAGAAGCCATGACCGCCTGCCCTACCAGAGGAGGTACCGGGAGCGCCGTGACAGCGATACATACCGGTG
TGAAGAGCGGAGCCCATCCTTTGGAGAGGACTACTATGGACCTTCACGTTCTCGTCATCGTCGGCGATCGCGGGAGAGGGGGCCATACCG
GACCCGCAAGCATGCCCACCACTGCCACAAACGCCGCACCAGGTCTTGTAGCAGCGCCTCCTCGAGAAGCCAACAGAGCAGTAAGCGCAG
CAGCCGGAGTGTGGAAGATGACAAGGAGGGTCACCTGGTGTGCCGGATCGGCGATTGGCTCCAAGAGCGATATGAGATTGTGGGGAACCT
GGGTGAAGGCACCTTTGGCAAGGTGGTGGAGTGCTTGGACCATGCCAGAGGGAAGTCTCAGGTTGCCCTGAAGATCATCCGCAACGTGGG
CAAGTACCGGGAGGCTGCCCGGCTAGAAATCAACGTGCTCAAAAAAATCAAGGAGAAGGACAAAGAAAACAAGTTGGAGAAGAAACAAGA
AGCATAAAAGGTACAGATTGAGCATCATTCTTTCAAAATAGAATCCTGTCAAGAAATGCATTGAAAGCGTCATGATTCACATGGAAAAGA
GGTGAAATGGATCTTCAGACACTTCATGTTACTGTCCCTTTTCCCTCCAGGACTGCAGGAGGTGCTGTGGGTTGGAGCCGTGGGCTGTGG
AGGGTTTGTGTATGATGAGAAGCCCTGTACAGTCTTGTCAAGAAATACCCTGAGCCAGTCTCTGAGACGCTTCGGTAAAAAATGTCCCTG
GATGGAATCAAGATTTTAAATTCAAATAAAGCCTAATATCATGTTGTGTCCACATTATTTAGTCTTTTTTTTTTTCTTTTGAGATGGAGT
CTCACTTTGTCGCCCAGGCTGGGGTGCAGTGGCGTGATCTCAGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCA
GCCTCCCGAGTAGCTGGGACTACAGGTACCCGCCACCATGCCCGGCTAAATTTTTGTATTTTTTTTTTAGTAGAGATGGGGTTTCACCGT
GTTAGCCAGGATGGTCTCCATCTCCTGACCTAGTGGTCTGCCCGCCTCGACCTCCCAAAGTGCTGGAATTACATGCATGAGCCACTGCGC
CTGACCCTATTTAGTCTTAAGTAACTAACTGAATTACTAGTAATTTTTAAAAGGTTGGAATGGTGGGCCAAACAGTAAGATGAAGTTTCG
ACGAGTAGGTCAGTTCTTTTCCTTGGGTCCAGGAAACTATTGAGCAGCAACAGAAGATCAGAGCAGAGATGTGGCTAAACAGTAGCAGGT
ATGAAAAGACTTAGAGGTTCTGGTTTCTGTAAGCTTCAAATATCTGTGATGCTTGTGCCAAAACAGCTTAAGTAGACTGTATTGTTTGAG
AGTTAGTATCGAGAACAAGGGAAGAACTGGTTTCACTCTGCACTTCTGATCTTTACAACAGGGCAATTGAAGGAACAGACTAAAAATCGT
GTCCTGGAAGGAAACTACAGGTACTACCAGGGATTTTCAGTCTGAAGAAGAAAAGACAAAATAGATGACAGAAGGAGTATTAGAAGGGAG
AGCGATGAGACTCAGTTGGACACCGAGAGAGCAAAGAAGCAATAATACGTGAAGATGAAAATGAAATCAATTTCAGCATAAGAAGACAAG
AACTTATGGTAAAGCTGCCCACAGCCAGAAGAGGATCCTAGAAGGACAGGAATTCCCTGTCTGCAGCATTTCATAAGCATGTAATATTGT
TGCAGGGATACTGCAGAAGGAGTTGAAGCAGTGGACAGACAGATGATATAGGTGATTTTACAGCCTAAGAAAGCCCTGTGCTTGTGCCCC
CAAAACATGAGGTGCTAGTGAATGAATGCTGGGGGAAAGCCCAGGGCCTAGGTGTTGCAATGTTCTGTGGTTGGCAGATGCTTTTTGTTT

>17213_17213_1_CLK3-ZSWIM7_CLK3_chr15_74917357_ENST00000345005_ZSWIM7_chr17_15881382_ENST00000399277_length(amino acids)=234AA_BP=
MECTGRNGAVQMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSF
GEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGK

--------------------------------------------------------------
>17213_17213_2_CLK3-ZSWIM7_CLK3_chr15_74917357_ENST00000352989_ZSWIM7_chr17_15881382_ENST00000399277_length(transcript)=2115nt_BP=606nt
AGCTGCAGCCGGAGCCTGGGAGACGATGCATCACTGTAAGCGATACCGCTCCCCTGAACCAGACCCGTACCTGAGCTACCGATGGAAGAG
GAGGAGGTCCTACAGTCGGGAACATGAAGGGAGACTGCGATACCCGTCCCGAAGGGAGCCTCCCCCACGAAGATCTCGGTCCAGAAGCCA
TGACCGCCTGCCCTACCAGAGGAGGTACCGGGAGCGCCGTGACAGCGATACATACCGGTGTGAAGAGCGGAGCCCATCCTTTGGAGAGGA
CTACTATGGACCTTCACGTTCTCGTCATCGTCGGCGATCGCGGGAGAGGGGGCCATACCGGACCCGCAAGCATGCCCACCACTGCCACAA
ACGCCGCACCAGGTCTTGTAGCAGCGCCTCCTCGAGAAGCCAACAGAGCAGTAAGCGCAGCAGCCGGAGTGTGGAAGATGACAAGGAGGG
TCACCTGGTGTGCCGGATCGGCGATTGGCTCCAAGAGCGATGGAAGTCTCAGGTTGCCCTGAAGATCATCCGCAACGTGGGCAAGTACCG
GGAGGCTGCCCGGCTAGAAATCAACGTGCTCAAAAAAATCAAGGAGAAGGACAAAGAAAACAAGTTGGAGAAGAAACAAGAAGCATAAAA
GGTACAGATTGAGCATCATTCTTTCAAAATAGAATCCTGTCAAGAAATGCATTGAAAGCGTCATGATTCACATGGAAAAGAGGTGAAATG
GATCTTCAGACACTTCATGTTACTGTCCCTTTTCCCTCCAGGACTGCAGGAGGTGCTGTGGGTTGGAGCCGTGGGCTGTGGAGGGTTTGT
GTATGATGAGAAGCCCTGTACAGTCTTGTCAAGAAATACCCTGAGCCAGTCTCTGAGACGCTTCGGTAAAAAATGTCCCTGGATGGAATC
AAGATTTTAAATTCAAATAAAGCCTAATATCATGTTGTGTCCACATTATTTAGTCTTTTTTTTTTTCTTTTGAGATGGAGTCTCACTTTG
TCGCCCAGGCTGGGGTGCAGTGGCGTGATCTCAGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGA
GTAGCTGGGACTACAGGTACCCGCCACCATGCCCGGCTAAATTTTTGTATTTTTTTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAG
GATGGTCTCCATCTCCTGACCTAGTGGTCTGCCCGCCTCGACCTCCCAAAGTGCTGGAATTACATGCATGAGCCACTGCGCCTGACCCTA
TTTAGTCTTAAGTAACTAACTGAATTACTAGTAATTTTTAAAAGGTTGGAATGGTGGGCCAAACAGTAAGATGAAGTTTCGACGAGTAGG
TCAGTTCTTTTCCTTGGGTCCAGGAAACTATTGAGCAGCAACAGAAGATCAGAGCAGAGATGTGGCTAAACAGTAGCAGGTATGAAAAGA
CTTAGAGGTTCTGGTTTCTGTAAGCTTCAAATATCTGTGATGCTTGTGCCAAAACAGCTTAAGTAGACTGTATTGTTTGAGAGTTAGTAT
CGAGAACAAGGGAAGAACTGGTTTCACTCTGCACTTCTGATCTTTACAACAGGGCAATTGAAGGAACAGACTAAAAATCGTGTCCTGGAA
GGAAACTACAGGTACTACCAGGGATTTTCAGTCTGAAGAAGAAAAGACAAAATAGATGACAGAAGGAGTATTAGAAGGGAGAGCGATGAG
ACTCAGTTGGACACCGAGAGAGCAAAGAAGCAATAATACGTGAAGATGAAAATGAAATCAATTTCAGCATAAGAAGACAAGAACTTATGG
TAAAGCTGCCCACAGCCAGAAGAGGATCCTAGAAGGACAGGAATTCCCTGTCTGCAGCATTTCATAAGCATGTAATATTGTTGCAGGGAT
ACTGCAGAAGGAGTTGAAGCAGTGGACAGACAGATGATATAGGTGATTTTACAGCCTAAGAAAGCCCTGTGCTTGTGCCCCCAAAACATG
AGGTGCTAGTGAATGAATGCTGGGGGAAAGCCCAGGGCCTAGGTGTTGCAATGTTCTGTGGTTGGCAGATGCTTTTTGTTTTGTTAAAAA

>17213_17213_2_CLK3-ZSWIM7_CLK3_chr15_74917357_ENST00000352989_ZSWIM7_chr17_15881382_ENST00000399277_length(amino acids)=200AA_BP=
MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSR
HRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERWKSQVALKIIRNVGKYREAARLEIN

--------------------------------------------------------------
>17213_17213_3_CLK3-ZSWIM7_CLK3_chr15_74917357_ENST00000395066_ZSWIM7_chr17_15881382_ENST00000399277_length(transcript)=3064nt_BP=1555nt
AGTTTTCTCATCTGGAAAGTGGGGCCTCGTAATCCTGTCCGACCCGGCGCGGGACAGTAGGTGTCAGGGATTTTGGTGACCCCACGCTCG
AGGCCTCTGCAAAAGGGGGCTGTCCAGTGGCCCAGAGACGCAGCCGGCGGGGCTTTTGTCTAGCGGGGGAGTCTTAACTGAGAGGCCACG
CAGGCCGGCAGGAAGCCGCTCCACAGGAGGGGGCTCAAGGAGAGGGGATCTCCTCCCTCCAGACTCCGGCCCCGCCAGAGTAGCTCTAGG
GTATCTTCCCAGAAACTGCCCCGCACGCACTGGCGAGCTGGGAGCGCCACCACGGCTTTCAAAAAACCCGCACACACCAAGATAATAATG
TGTCGTTCGCTCGTTTCGCGCAAGCGGAGTCGCGTCCGCCTTCCCGAGCTCCGGCACACAGACCTCAGGCCGCTCTCGCGCTCTCCGGGG
CCCCGAGAACAATGCCCGTCCTCTCCGCGCGCAGGAGGGAGTTGGCGGACCACGCGGGGTCGGGGCGACGGAGCGGGCCCAGCCCCACGG
CCAGGTCGGGGCCCCACCTCTCGGCTCTGAGAGCCCAGCCGGCCCGGGCCGCGCACCTGTCAGGTCGGGGGACCTACGTGCGCCGCGACA
CGGCGGGAGGCGGGCCGGGCCAGGCTCGTCCCCTCGGCCCTCCCGGAACTAGTCTCCTAGGCCGCGGCGCCCGCCGGAGCGGAGAGGGCT
GGTGCCCCGGAGCCTTCGAGTCGGGGGCTAGAGCGGCCAGGCCTCCGAGCCGGGTCGAGCCGAGGCTGGCGACGGCTGCGTCACGCGAGG
GGGCGGGGCTGCCACGGGCGGAGGTCGCAGCCGGAAGCGGAAGAGGCGCTCGGAGCGGGGAGTGGGGCCTAGCTGCAGCCGGAGCCTGGG
AGACGATGCATCACTGTAAGCGATACCGCTCCCCTGAACCAGACCCGTACCTGAGCTACCGATGGAAGAGGAGGAGGTCCTACAGTCGGG
AACATGAAGGGAGACTGCGATACCCGTCCCGAAGGGAGCCTCCCCCACGAAGATCTCGGTCCAGAAGCCATGACCGCCTGCCCTACCAGA
GGAGGTACCGGGAGCGCCGTGACAGCGATACATACCGGTGTGAAGAGCGGAGCCCATCCTTTGGAGAGGACTACTATGGACCTTCACGTT
CTCGTCATCGTCGGCGATCGCGGGAGAGGGGGCCATACCGGACCCGCAAGCATGCCCACCACTGCCACAAACGCCGCACCAGGTCTTGTA
GCAGCGCCTCCTCGAGAAGCCAACAGAGCAGTAAGCGCAGCAGCCGGAGTGTGGAAGATGACAAGGAGGGTCACCTGGTGTGCCGGATCG
GCGATTGGCTCCAAGAGCGATATGAGATTGTGGGGAACCTGGGTGAAGGCACCTTTGGCAAGGTGGTGGAGTGCTTGGACCATGCCAGAG
GGAAGTCTCAGGTTGCCCTGAAGATCATCCGCAACGTGGGCAAGTACCGGGAGGCTGCCCGGCTAGAAATCAACGTGCTCAAAAAAATCA
AGGAGAAGGACAAAGAAAACAAGTTGGAGAAGAAACAAGAAGCATAAAAGGTACAGATTGAGCATCATTCTTTCAAAATAGAATCCTGTC
AAGAAATGCATTGAAAGCGTCATGATTCACATGGAAAAGAGGTGAAATGGATCTTCAGACACTTCATGTTACTGTCCCTTTTCCCTCCAG
GACTGCAGGAGGTGCTGTGGGTTGGAGCCGTGGGCTGTGGAGGGTTTGTGTATGATGAGAAGCCCTGTACAGTCTTGTCAAGAAATACCC
TGAGCCAGTCTCTGAGACGCTTCGGTAAAAAATGTCCCTGGATGGAATCAAGATTTTAAATTCAAATAAAGCCTAATATCATGTTGTGTC
CACATTATTTAGTCTTTTTTTTTTTCTTTTGAGATGGAGTCTCACTTTGTCGCCCAGGCTGGGGTGCAGTGGCGTGATCTCAGCTCACTG
CAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTACCCGCCACCATGCCCGGCTAAA
TTTTTGTATTTTTTTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAGGATGGTCTCCATCTCCTGACCTAGTGGTCTGCCCGCCTCGA
CCTCCCAAAGTGCTGGAATTACATGCATGAGCCACTGCGCCTGACCCTATTTAGTCTTAAGTAACTAACTGAATTACTAGTAATTTTTAA
AAGGTTGGAATGGTGGGCCAAACAGTAAGATGAAGTTTCGACGAGTAGGTCAGTTCTTTTCCTTGGGTCCAGGAAACTATTGAGCAGCAA
CAGAAGATCAGAGCAGAGATGTGGCTAAACAGTAGCAGGTATGAAAAGACTTAGAGGTTCTGGTTTCTGTAAGCTTCAAATATCTGTGAT
GCTTGTGCCAAAACAGCTTAAGTAGACTGTATTGTTTGAGAGTTAGTATCGAGAACAAGGGAAGAACTGGTTTCACTCTGCACTTCTGAT
CTTTACAACAGGGCAATTGAAGGAACAGACTAAAAATCGTGTCCTGGAAGGAAACTACAGGTACTACCAGGGATTTTCAGTCTGAAGAAG
AAAAGACAAAATAGATGACAGAAGGAGTATTAGAAGGGAGAGCGATGAGACTCAGTTGGACACCGAGAGAGCAAAGAAGCAATAATACGT
GAAGATGAAAATGAAATCAATTTCAGCATAAGAAGACAAGAACTTATGGTAAAGCTGCCCACAGCCAGAAGAGGATCCTAGAAGGACAGG
AATTCCCTGTCTGCAGCATTTCATAAGCATGTAATATTGTTGCAGGGATACTGCAGAAGGAGTTGAAGCAGTGGACAGACAGATGATATA
GGTGATTTTACAGCCTAAGAAAGCCCTGTGCTTGTGCCCCCAAAACATGAGGTGCTAGTGAATGAATGCTGGGGGAAAGCCCAGGGCCTA
GGTGTTGCAATGTTCTGTGGTTGGCAGATGCTTTTTGTTTTGTTAAAAAGTGCAACAGATAAAATTTATCAATACTTTTCTGCTACTCAG

>17213_17213_3_CLK3-ZSWIM7_CLK3_chr15_74917357_ENST00000395066_ZSWIM7_chr17_15881382_ENST00000399277_length(amino acids)=425AA_BP=
MASWERHHGFQKTRTHQDNNVSFARFAQAESRPPSRAPAHRPQAALALSGAPRTMPVLSARRRELADHAGSGRRSGPSPTARSGPHLSAL
RAQPARAAHLSGRGTYVRRDTAGGGPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGLPRAEVA
AGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSD
TYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEI

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Fusion Gene PPI Analysis for CLK3-ZSWIM7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CLK3-ZSWIM7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCLK3P49761DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for CLK3-ZSWIM7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource