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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FGD4-FAU (FusionGDB2 ID:HG121512TG2197)

Fusion Gene Summary for FGD4-FAU

check button Fusion gene summary
Fusion gene informationFusion gene name: FGD4-FAU
Fusion gene ID: hg121512tg2197
HgeneTgene
Gene symbol

FGD4

FAU

Gene ID

121512

2197

Gene nameFYVE, RhoGEF and PH domain containing 4FAU ubiquitin like and ribosomal protein S30 fusion
SynonymsCMT4H|FRABP|ZFYVE6FAU1|Fub1|Fubi|MNSFbeta|RPS30|S30|asr1
Cytomap('FGD4')('FAU')

12p11.21

11q13.1

Type of geneprotein-codingprotein-coding
DescriptionFYVE, RhoGEF and PH domain-containing protein 4FGD1 family, member 4FGD1-related F-actin-binding proteinactin-filament binding protein frabinzinc finger FYVE domain-containing protein 6ubiquitin-like protein fubi and ribosomal protein S3040S ribosomal protein S30FAU-encoded ubiquitin-like proteinFBR-MuSV-associated ubiquitously expressedFinkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)monoclo
Modification date2020032820200313
UniProtAcc.

P35544

Ensembl transtripts involved in fusion geneENST00000266482, ENST00000381025, 
ENST00000427716, ENST00000525053, 
ENST00000531134, ENST00000534526, 
ENST00000546442, ENST00000472289, 
ENST00000473513, 
Fusion gene scores* DoF score19 X 13 X 13=321114 X 8 X 3=336
# samples 2214
** MAII scorelog2(22/3211*10)=-3.86744723620111
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/336*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGD4 [Title/Abstract] AND FAU [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFGD4(32764108)-FAU(64888268), # samples:1
Anticipated loss of major functional domain due to fusion event.FGD4-FAU seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FGD4-FAU seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FGD4-FAU seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FGD4-FAU seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
FGD4-FAU seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FGD4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across FAU (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-A4MH-01AFGD4chr12

32764108

+FAUchr11

64888268

-


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Fusion Gene ORF analysis for FGD4-FAU

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000266482ENST00000529259FGD4chr12

32764108

+FAUchr11

64888268

-
5CDS-3UTRENST00000381025ENST00000529259FGD4chr12

32764108

+FAUchr11

64888268

-
5CDS-3UTRENST00000427716ENST00000529259FGD4chr12

32764108

+FAUchr11

64888268

-
5CDS-3UTRENST00000525053ENST00000529259FGD4chr12

32764108

+FAUchr11

64888268

-
5CDS-3UTRENST00000531134ENST00000529259FGD4chr12

32764108

+FAUchr11

64888268

-
5CDS-3UTRENST00000534526ENST00000529259FGD4chr12

32764108

+FAUchr11

64888268

-
5CDS-3UTRENST00000546442ENST00000529259FGD4chr12

32764108

+FAUchr11

64888268

-
5CDS-intronENST00000266482ENST00000434372FGD4chr12

32764108

+FAUchr11

64888268

-
5CDS-intronENST00000381025ENST00000434372FGD4chr12

32764108

+FAUchr11

64888268

-
5CDS-intronENST00000427716ENST00000434372FGD4chr12

32764108

+FAUchr11

64888268

-
5CDS-intronENST00000525053ENST00000434372FGD4chr12

32764108

+FAUchr11

64888268

-
5CDS-intronENST00000531134ENST00000434372FGD4chr12

32764108

+FAUchr11

64888268

-
5CDS-intronENST00000534526ENST00000434372FGD4chr12

32764108

+FAUchr11

64888268

-
5CDS-intronENST00000546442ENST00000434372FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000266482ENST00000279259FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000266482ENST00000525297FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000266482ENST00000527548FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000266482ENST00000529639FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000381025ENST00000279259FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000381025ENST00000525297FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000381025ENST00000527548FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000381025ENST00000529639FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000427716ENST00000279259FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000427716ENST00000525297FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000427716ENST00000527548FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000427716ENST00000529639FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000525053ENST00000279259FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000525053ENST00000525297FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000525053ENST00000527548FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000525053ENST00000529639FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000531134ENST00000279259FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000531134ENST00000525297FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000531134ENST00000527548FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000531134ENST00000529639FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000534526ENST00000279259FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000534526ENST00000525297FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000534526ENST00000527548FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000534526ENST00000529639FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000546442ENST00000279259FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000546442ENST00000525297FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000546442ENST00000527548FGD4chr12

32764108

+FAUchr11

64888268

-
Frame-shiftENST00000546442ENST00000529639FGD4chr12

32764108

+FAUchr11

64888268

-
In-frameENST00000266482ENST00000531743FGD4chr12

32764108

+FAUchr11

64888268

-
In-frameENST00000381025ENST00000531743FGD4chr12

32764108

+FAUchr11

64888268

-
In-frameENST00000427716ENST00000531743FGD4chr12

32764108

+FAUchr11

64888268

-
In-frameENST00000525053ENST00000531743FGD4chr12

32764108

+FAUchr11

64888268

-
In-frameENST00000531134ENST00000531743FGD4chr12

32764108

+FAUchr11

64888268

-
In-frameENST00000534526ENST00000531743FGD4chr12

32764108

+FAUchr11

64888268

-
In-frameENST00000546442ENST00000531743FGD4chr12

32764108

+FAUchr11

64888268

-
intron-3CDSENST00000472289ENST00000279259FGD4chr12

32764108

+FAUchr11

64888268

-
intron-3CDSENST00000472289ENST00000525297FGD4chr12

32764108

+FAUchr11

64888268

-
intron-3CDSENST00000472289ENST00000527548FGD4chr12

32764108

+FAUchr11

64888268

-
intron-3CDSENST00000472289ENST00000529639FGD4chr12

32764108

+FAUchr11

64888268

-
intron-3CDSENST00000472289ENST00000531743FGD4chr12

32764108

+FAUchr11

64888268

-
intron-3CDSENST00000473513ENST00000279259FGD4chr12

32764108

+FAUchr11

64888268

-
intron-3CDSENST00000473513ENST00000525297FGD4chr12

32764108

+FAUchr11

64888268

-
intron-3CDSENST00000473513ENST00000527548FGD4chr12

32764108

+FAUchr11

64888268

-
intron-3CDSENST00000473513ENST00000529639FGD4chr12

32764108

+FAUchr11

64888268

-
intron-3CDSENST00000473513ENST00000531743FGD4chr12

32764108

+FAUchr11

64888268

-
intron-3UTRENST00000472289ENST00000529259FGD4chr12

32764108

+FAUchr11

64888268

-
intron-3UTRENST00000473513ENST00000529259FGD4chr12

32764108

+FAUchr11

64888268

-
intron-intronENST00000472289ENST00000434372FGD4chr12

32764108

+FAUchr11

64888268

-
intron-intronENST00000473513ENST00000434372FGD4chr12

32764108

+FAUchr11

64888268

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000534526FGD4chr1232764108+ENST00000531743FAUchr1164888268-214319761781902574
ENST00000531134FGD4chr1232764108+ENST00000531743FAUchr1164888268-188417171621643493
ENST00000427716FGD4chr1232764108+ENST00000531743FAUchr1164888268-189117242411650469
ENST00000266482FGD4chr1232764108+ENST00000531743FAUchr1164888268-198118142311121296
ENST00000546442FGD4chr1232764108+ENST00000531743FAUchr1164888268-168315163301442370
ENST00000525053FGD4chr1232764108+ENST00000531743FAUchr1164888268-18871720841646520
ENST00000381025FGD4chr1232764108+ENST00000531743FAUchr1164888268-83867113597194

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000534526ENST00000531743FGD4chr1232764108+FAUchr1164888268-0.014340110.98565984
ENST00000531134ENST00000531743FGD4chr1232764108+FAUchr1164888268-0.0046727050.99532723
ENST00000427716ENST00000531743FGD4chr1232764108+FAUchr1164888268-0.0096566090.99034345
ENST00000266482ENST00000531743FGD4chr1232764108+FAUchr1164888268-0.0079253340.9920746
ENST00000546442ENST00000531743FGD4chr1232764108+FAUchr1164888268-0.004685780.99531424
ENST00000525053ENST00000531743FGD4chr1232764108+FAUchr1164888268-0.0021849180.997815
ENST00000381025ENST00000531743FGD4chr1232764108+FAUchr1164888268-0.0186149310.9813851

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Fusion Genomic Features for FGD4-FAU


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for FGD4-FAU


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:32764108/chr11:64888268)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FAU

P35544

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGD4chr12:32764108chr11:64888268ENST00000381025+19206_3930281.0DomainDH
HgeneFGD4chr12:32764108chr11:64888268ENST00000381025+19422_5210281.0DomainPH 1
HgeneFGD4chr12:32764108chr11:64888268ENST00000381025+19643_7400281.0DomainPH 2
HgeneFGD4chr12:32764108chr11:64888268ENST00000427716+117206_3930767.0DomainDH
HgeneFGD4chr12:32764108chr11:64888268ENST00000427716+117422_5210767.0DomainPH 1
HgeneFGD4chr12:32764108chr11:64888268ENST00000427716+117643_7400767.0DomainPH 2
HgeneFGD4chr12:32764108chr11:64888268ENST00000381025+191_1500281.0RegionActin filament-binding
HgeneFGD4chr12:32764108chr11:64888268ENST00000427716+1171_1500767.0RegionActin filament-binding
HgeneFGD4chr12:32764108chr11:64888268ENST00000381025+19559_6190281.0Zinc fingerFYVE-type
HgeneFGD4chr12:32764108chr11:64888268ENST00000427716+117559_6190767.0Zinc fingerFYVE-type


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Fusion Gene Sequence for FGD4-FAU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>30166_30166_1_FGD4-FAU_FGD4_chr12_32764108_ENST00000266482_FAU_chr11_64888268_ENST00000531743_length(transcript)=1981nt_BP=1814nt
CTGGGCTGGGAAGTGGGGAAAGCAGGGGAGCCTGTGCTGGGTGAGATTATCTGCAATGGACCGGGTTAATGGGAGGCTTGCTTTGGCTCG
CTGGAAGAACAAATGAAGGGAGTTTTACTTCAACCATTTGTGACTTCTGGCCAAGAGGAATAAATTCAGCTTTTATAAGGCAGCAGTACC
TGTCCAAAGATCGCTTTAGTTCCACCTTGCTCCACAAGCAGCACAACCACACTGGTTGGTGAGAATGTATCTGAAGAAGAGGCTCAGGGA
ATAAATGGGAACAGGCCAGCAAAACACTCAGCTGCAAGTCCAAAGCCACAAGTGCCTCCAAAGCCATTACACCTGCAGAATTCACCTTCG
TCCAATATACACCAAACCCCCAGGCATAAAGCTTTACCTAGTGCAAAACCAAGGATGGAGGAAATTAAACCTGCCTCTGCTTCTTGTGTC
TCAAAAGAAAAACCCAGTAAGGTATCAGATCTCATCAGTCGCTTTGAAGGAGGCAGCTCATTATCAAATTATAGTGATTTGAAGAAAGAG
TCTGCTGTGAACCTAAATGCTCCTAGAACCCCAGGAAGGCATGGATTGACAACCACACCTCAACAAAAACTCCTCTCCCAGCACTTGCCA
CAGAGGCAGGGAAATGATACAGATAAGACTCAGGGTGCACAGACTTGTGTGGCCAACGGTGTAATGGCAGCACAAAACCAGATGGAATGT
GAGGAGGAGAAAGCTGCCACTCTTAGCTCAGATACTTCTATTCAAGCTTCTGAACCCTTGCTTGATACGCACATAGTGAATGGAGAAAGA
GATGAAACTGCCACAGCTCCTGCATCACCCACAACAGACAGCTGTGATGGAAATGCTTCTGACAGTAGCTACAGGACTCCAGGCATAGGC
CCAGTGCTCCCCCTAGAAGAAAGAGGGGCAGAAACAGAAACCAAGGTACAAGAGAGGGAAAATGGGGAAAGCCCTCTGGAACTGGAGCAG
CTGGACCAGCACCATGAGATGAAGGAGACTAATGAGCAAAAACTTCACAAAATAGCCAATGAACTTTTGCTTACTGAAAGAGCTTATGTC
AACCGACTTGACCTCTTAGATCAGAAAATAGAGTGGAGGTGAATTTAGAAAATTAACAACCATCTGGACATTATGAAGGAATAGACCTCC
TTCTGCCTACATGTAACAGAATGGCAATTAAGAGGTATTTTATTGCAAACTGTTGGAAGAAGCAAACCGAGGCTCGTTTCCAGCAGAGAT
GGTGAATAAAATCTTTTCTAATATTTCATCAATAAATGCCTTCCATAGTAAATTCCTCTTGCCAGAGCTGGAGAAACGAATGCAAGAATG
GGAAACTACTCCTAGAATTGGAGACATCCTTCAGAAATTGGCACCATTCCTTAAGATGTATGGAGAATATGTGAAAGGATTTGATAATGC
AATGGAATTGGTTAAAAACATGACAGAACGTATTCCCCAGTTCAAATCAGTGGTTGAAGAAATTCAGAAACAGAAAATCTGTGGGAGCTT
AACTTTGCAGCATCACATGCTAGAACCTGTTCAGCGGATTCCCCGGTATGAGATGCTCCTTAAGGACTATCTAAGGAAATTGCCTCCTGA
TTCCCTGGACTGGAATGATGCTAAAAAATCACTTGAAATTATATCTACAGCAGCAAGCCATTCTAATAGTGCAATAAGGAAAATGGGGAG
AAGAAGAAGACATTGTAAACCCTTCAAATGAACTAATAAAAGAAGGACAGATCCTCAAACTAGCTGCTCGGAACACTTCAGCACAAGAAC
GCTACCTTTTCTTAAGGAGAAGAAGAAGAAGAAGACAGGTCGGGCTAAGCGGCGGATGCAGTACAACCGGCGCTTTGTCAACGTTGTGCC
CACCTTTGGCAAGAAGAAGGGCCCCAATGCCAACTCTTAAGTCTTTTGTAATTCTGGCTTTCTCTAATAAAAAAGCCACTTAGTTCAGTC

>30166_30166_1_FGD4-FAU_FGD4_chr12_32764108_ENST00000266482_FAU_chr11_64888268_ENST00000531743_length(amino acids)=296AA_BP=
MVGENVSEEEAQGINGNRPAKHSAASPKPQVPPKPLHLQNSPSSNIHQTPRHKALPSAKPRMEEIKPASASCVSKEKPSKVSDLISRFEG
GSSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQAS
EPLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHK

--------------------------------------------------------------
>30166_30166_2_FGD4-FAU_FGD4_chr12_32764108_ENST00000381025_FAU_chr11_64888268_ENST00000531743_length(transcript)=838nt_BP=671nt
AGCCAATGAACTTTTGCTTACTGAAAGAGCTTATGTCAACCGACTTGACCTCTTAGATCAGGTATTTTATTGCAAACTGTTGGAAGAAGC
AAACCGAGGCTCGTTTCCAGCAGAGATGGTGAATAAAATCTTTTCTAATATTTCATCAATAAATGCCTTCCATAGTAAATTCCTCTTGCC
AGAGCTGGAGAAACGAATGCAAGAATGGGAAACTACTCCTAGAATTGGAGACATCCTTCAGAAATTGGCACCATTCCTTAAGATGTATGG
AGAATATGTGAAAGGATTTGATAATGCAATGGAATTGGTTAAAAACATGACAGAACGTATTCCCCAGTTCAAATCAGTGGTTGAAGAAAT
TCAGAAACAGAAAATCTGTGGGAGCTTAACTTTGCAGCATCACATGCTAGAACCTGTTCAGCGGATTCCCCGGTATGAGATGCTCCTTAA
GGACTATCTAAGGAAATTGCCTCCTGATTCCCTGGACTGGAATGATGCTAAAAAATCACTTGAAATTATATCTACAGCAGCAAGCCATTC
TAATAGTGCAATAAGGAAAATGGGGAGAAGAAGAAGACATTGTAAACCCTTCAAATGAACTAATAAAAGAAGGACAGATCCTCAAACTAG
CTGCTCGGAACACTTCAGCACAAGAACGCTACCTTTTCTTAAGGAGAAGAAGAAGAAGAAGACAGGTCGGGCTAAGCGGCGGATGCAGTA
CAACCGGCGCTTTGTCAACGTTGTGCCCACCTTTGGCAAGAAGAAGGGCCCCAATGCCAACTCTTAAGTCTTTTGTAATTCTGGCTTTCT

>30166_30166_2_FGD4-FAU_FGD4_chr12_32764108_ENST00000381025_FAU_chr11_64888268_ENST00000531743_length(amino acids)=194AA_BP=
MLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVK
GFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAI

--------------------------------------------------------------
>30166_30166_3_FGD4-FAU_FGD4_chr12_32764108_ENST00000427716_FAU_chr11_64888268_ENST00000531743_length(transcript)=1891nt_BP=1724nt
ATTATCCTTGCTGGGCTGGGAAGTGGGGAAAGCAGGGGAGCCTGTGCTGGGTGAGATTATCTGCAATGGACCGGGTTAATGGGAGGCTTG
CTTTGGCTCGCTGGAAGAACAAATGAAGGGAGTTTTACTTCAACCATTTGTGACTTCTGGCCAAGAGGAATAAATTCAGCTTTTATAAGG
CAGCAGTACCTGTCCAAAGATCGCTTTAGTTCCACCTTGCTCCACAAGCAGCACAACCACACTGGTTGGTGAGAATGTATCTGAAGAAGA
GGCTCAGGGAATAAATGGGAACAGGCCAGCAAAACACTCAGCTGCAAGTCCAAAGCCACAAGTGCCTCCAAAGCCATTACACCTGCAGAA
TTCACCTTCGTCCAATATACACCAAACCCCCAGGCATAAAGCTTTACCTAGTGCAAAACCAAGGATGGAGGAAATTAAACCTGCCTCTGC
TTCTTGTGTCTCAAAAGAAAAACCCAGTAAGGTATCAGATCTCATCAGTCGCTTTGAAGGAGGCAGCTCATTATCAAATTATAGTGATTT
GAAGAAAGAGTCTGCTGTGAACCTAAATGCTCCTAGAACCCCAGGAAGGCATGGATTGACAACCACACCTCAACAAAAACTCCTCTCCCA
GCACTTGCCACAGAGGCAGGGAAATGATACAGATAAGACTCAGGGTGCACAGACTTGTGTGGCCAACGGTGTAATGGCAGCACAAAACCA
GATGGAATGTGAGGAGGAGAAAGCTGCCACTCTTAGCTCAGATACTTCTATTCAAGCTTCTGAACCCTTGCTTGATACGCACATAGTGAA
TGGAGAAAGAGATGAAACTGCCACAGCTCCTGCATCACCCACAACAGACAGCTGTGATGGAAATGCTTCTGACAGTAGCTACAGGACTCC
AGGCATAGGCCCAGTGCTCCCCCTAGAAGAAAGAGGGGCAGAAACAGAAACCAAGGTACAAGAGAGGGAAAATGGGGAAAGCCCTCTGGA
ACTGGAGCAGCTGGACCAGCACCATGAGATGAAGGAGACTAATGAGCAAAAACTTCACAAAATAGCCAATGAACTTTTGCTTACTGAAAG
AGCTTATGTCAACCGACTTGACCTCTTAGATCAGGTATTTTATTGCAAACTGTTGGAAGAAGCAAACCGAGGCTCGTTTCCAGCAGAGAT
GGTGAATAAAATCTTTTCTAATATTTCATCAATAAATGCCTTCCATAGTAAATTCCTCTTGCCAGAGCTGGAGAAACGAATGCAAGAATG
GGAAACTACTCCTAGAATTGGAGACATCCTTCAGAAATTGGCACCATTCCTTAAGATGTATGGAGAATATGTGAAAGGATTTGATAATGC
AATGGAATTGGTTAAAAACATGACAGAACGTATTCCCCAGTTCAAATCAGTGGTTGAAGAAATTCAGAAACAGAAAATCTGTGGGAGCTT
AACTTTGCAGCATCACATGCTAGAACCTGTTCAGCGGATTCCCCGGTATGAGATGCTCCTTAAGGACTATCTAAGGAAATTGCCTCCTGA
TTCCCTGGACTGGAATGATGCTAAAAAATCACTTGAAATTATATCTACAGCAGCAAGCCATTCTAATAGTGCAATAAGGAAAATGGGGAG
AAGAAGAAGACATTGTAAACCCTTCAAATGAACTAATAAAAGAAGGACAGATCCTCAAACTAGCTGCTCGGAACACTTCAGCACAAGAAC
GCTACCTTTTCTTAAGGAGAAGAAGAAGAAGAAGACAGGTCGGGCTAAGCGGCGGATGCAGTACAACCGGCGCTTTGTCAACGTTGTGCC
CACCTTTGGCAAGAAGAAGGGCCCCAATGCCAACTCTTAAGTCTTTTGTAATTCTGGCTTTCTCTAATAAAAAAGCCACTTAGTTCAGTC

>30166_30166_3_FGD4-FAU_FGD4_chr12_32764108_ENST00000427716_FAU_chr11_64888268_ENST00000531743_length(amino acids)=469AA_BP=
MVGENVSEEEAQGINGNRPAKHSAASPKPQVPPKPLHLQNSPSSNIHQTPRHKALPSAKPRMEEIKPASASCVSKEKPSKVSDLISRFEG
GSSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQAS
EPLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHK
IANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMY
GEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASH

--------------------------------------------------------------
>30166_30166_4_FGD4-FAU_FGD4_chr12_32764108_ENST00000525053_FAU_chr11_64888268_ENST00000531743_length(transcript)=1887nt_BP=1720nt
AGTGCATTGGTCTGAGCTCCTGGCAGATCCTGTGTAATCTTCAGCCTCCCTGAAGCTTTACAGCCAGGAGTGAGATTTTATCACATGAAC
TTTAAAAGAGTAAAGCCAAATATCTTTTTATTAAACCAGAGTAGATTAATTATCAGTATATGTGAAATCATGTCCACTGATCAAGGCAGC
AGTACCTGTCCAAAGATCGCTTTAGTTCCACCTTGCTCCACAAGCAGCACAACCACACTGGTTGGTGAGAATGTATCTGAAGAAGAGGCT
CAGGGAATAAATGGGAACAGGCCAGCAAAACACTCAGCTGCAAGTCCAAAGCCACAAGTGCCTCCAAAGCCATTACACCTGCAGAATTCA
CCTTCGTCCAATATACACCAAACCCCCAGGCATAAAGCTTTACCTAGTGCAAAACCAAGGATGGAGGAAATTAAACCTGCCTCTGCTTCT
TGTGTCTCAAAAGAAAAACCCAGTAAGGTATCAGATCTCATCAGTCGCTTTGAAGGAGGCAGCTCATTATCAAATTATAGTGATTTGAAG
AAAGAGTCTGCTGTGAACCTAAATGCTCCTAGAACCCCAGGAAGGCATGGATTGACAACCACACCTCAACAAAAACTCCTCTCCCAGCAC
TTGCCACAGAGGCAGGGAAATGATACAGATAAGACTCAGGGTGCACAGACTTGTGTGGCCAACGGTGTAATGGCAGCACAAAACCAGATG
GAATGTGAGGAGGAGAAAGCTGCCACTCTTAGCTCAGATACTTCTATTCAAGCTTCTGAACCCTTGCTTGATACGCACATAGTGAATGGA
GAAAGAGATGAAACTGCCACAGCTCCTGCATCACCCACAACAGACAGCTGTGATGGAAATGCTTCTGACAGTAGCTACAGGACTCCAGGC
ATAGGCCCAGTGCTCCCCCTAGAAGAAAGAGGGGCAGAAACAGAAACCAAGGTACAAGAGAGGGAAAATGGGGAAAGCCCTCTGGAACTG
GAGCAGCTGGACCAGCACCATGAGATGAAGGAGACTAATGAGCAAAAACTTCACAAAATAGCCAATGAACTTTTGCTTACTGAAAGAGCT
TATGTCAACCGACTTGACCTCTTAGATCAGGTATTTTATTGCAAACTGTTGGAAGAAGCAAACCGAGGCTCGTTTCCAGCAGAGATGGTG
AATAAAATCTTTTCTAATATTTCATCAATAAATGCCTTCCATAGTAAATTCCTCTTGCCAGAGCTGGAGAAACGAATGCAAGAATGGGAA
ACTACTCCTAGAATTGGAGACATCCTTCAGAAATTGGCACCATTCCTTAAGATGTATGGAGAATATGTGAAAGGATTTGATAATGCAATG
GAATTGGTTAAAAACATGACAGAACGTATTCCCCAGTTCAAATCAGTGGTTGAAGAAATTCAGAAACAGAAAATCTGTGGGAGCTTAACT
TTGCAGCATCACATGCTAGAACCTGTTCAGCGGATTCCCCGGTATGAGATGCTCCTTAAGGACTATCTAAGGAAATTGCCTCCTGATTCC
CTGGACTGGAATGATGCTAAAAAATCACTTGAAATTATATCTACAGCAGCAAGCCATTCTAATAGTGCAATAAGGAAAATGGGGAGAAGA
AGAAGACATTGTAAACCCTTCAAATGAACTAATAAAAGAAGGACAGATCCTCAAACTAGCTGCTCGGAACACTTCAGCACAAGAACGCTA
CCTTTTCTTAAGGAGAAGAAGAAGAAGAAGACAGGTCGGGCTAAGCGGCGGATGCAGTACAACCGGCGCTTTGTCAACGTTGTGCCCACC

>30166_30166_4_FGD4-FAU_FGD4_chr12_32764108_ENST00000525053_FAU_chr11_64888268_ENST00000531743_length(amino acids)=520AA_BP=
MNFKRVKPNIFLLNQSRLIISICEIMSTDQGSSTCPKIALVPPCSTSSTTTLVGENVSEEEAQGINGNRPAKHSAASPKPQVPPKPLHLQ
NSPSSNIHQTPRHKALPSAKPRMEEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLS
QHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRT
PGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAE
MVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGS

--------------------------------------------------------------
>30166_30166_5_FGD4-FAU_FGD4_chr12_32764108_ENST00000531134_FAU_chr11_64888268_ENST00000531743_length(transcript)=1884nt_BP=1717nt
AGTTAGTTCTTTATCATGTTGAACACTAGATGTGTATGTGTCTAGTGTCTAAATACAGAATGCCTATAGTTTCTACCAACAAATTATGGA
TCCAAATCCTTGCTCCAGAAGCAGGAAATAGGTTAATCAGAAGATTGCTGGATGTTATGAAAAGAATCTTTTATGGGGGGCTGCAGCAGT
ACCTGTCCAAAGATCGCTTTAGTTCCACCTTGCTCCACAAGCAGCACAACCACACTGGTTGGTGAGAATGTATCTGAAGAAGAGGCTCAG
GGAATAAATGGGAACAGGCCAGCAAAACACTCAGCTGCAAGTCCAAAGCCACAAGTGCCTCCAAAGCCATTACACCTGCAGAATTCACCT
TCGTCCAATATACACCAAACCCCCAGGCATAAAGCTTTACCTAGTGCAAAACCAAGGATGGAGGAAATTAAACCTGCCTCTGCTTCTTGT
GTCTCAAAAGAAAAACCCAGTAAGGTATCAGATCTCATCAGTCGCTTTGAAGGAGGCAGCTCATTATCAAATTATAGTGATTTGAAGAAA
GAGTCTGCTGTGAACCTAAATGCTCCTAGAACCCCAGGAAGGCATGGATTGACAACCACACCTCAACAAAAACTCCTCTCCCAGCACTTG
CCACAGAGGCAGGGAAATGATACAGATAAGACTCAGGGTGCACAGACTTGTGTGGCCAACGGTGTAATGGCAGCACAAAACCAGATGGAA
TGTGAGGAGGAGAAAGCTGCCACTCTTAGCTCAGATACTTCTATTCAAGCTTCTGAACCCTTGCTTGATACGCACATAGTGAATGGAGAA
AGAGATGAAACTGCCACAGCTCCTGCATCACCCACAACAGACAGCTGTGATGGAAATGCTTCTGACAGTAGCTACAGGACTCCAGGCATA
GGCCCAGTGCTCCCCCTAGAAGAAAGAGGGGCAGAAACAGAAACCAAGGTACAAGAGAGGGAAAATGGGGAAAGCCCTCTGGAACTGGAG
CAGCTGGACCAGCACCATGAGATGAAGGAGACTAATGAGCAAAAACTTCACAAAATAGCCAATGAACTTTTGCTTACTGAAAGAGCTTAT
GTCAACCGACTTGACCTCTTAGATCAGGTATTTTATTGCAAACTGTTGGAAGAAGCAAACCGAGGCTCGTTTCCAGCAGAGATGGTGAAT
AAAATCTTTTCTAATATTTCATCAATAAATGCCTTCCATAGTAAATTCCTCTTGCCAGAGCTGGAGAAACGAATGCAAGAATGGGAAACT
ACTCCTAGAATTGGAGACATCCTTCAGAAATTGGCACCATTCCTTAAGATGTATGGAGAATATGTGAAAGGATTTGATAATGCAATGGAA
TTGGTTAAAAACATGACAGAACGTATTCCCCAGTTCAAATCAGTGGTTGAAGAAATTCAGAAACAGAAAATCTGTGGGAGCTTAACTTTG
CAGCATCACATGCTAGAACCTGTTCAGCGGATTCCCCGGTATGAGATGCTCCTTAAGGACTATCTAAGGAAATTGCCTCCTGATTCCCTG
GACTGGAATGATGCTAAAAAATCACTTGAAATTATATCTACAGCAGCAAGCCATTCTAATAGTGCAATAAGGAAAATGGGGAGAAGAAGA
AGACATTGTAAACCCTTCAAATGAACTAATAAAAGAAGGACAGATCCTCAAACTAGCTGCTCGGAACACTTCAGCACAAGAACGCTACCT
TTTCTTAAGGAGAAGAAGAAGAAGAAGACAGGTCGGGCTAAGCGGCGGATGCAGTACAACCGGCGCTTTGTCAACGTTGTGCCCACCTTT

>30166_30166_5_FGD4-FAU_FGD4_chr12_32764108_ENST00000531134_FAU_chr11_64888268_ENST00000531743_length(amino acids)=493AA_BP=
MGGCSSTCPKIALVPPCSTSSTTTLVGENVSEEEAQGINGNRPAKHSAASPKPQVPPKPLHLQNSPSSNIHQTPRHKALPSAKPRMEEIK
PASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMA
AQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQERENGE
SPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKR
MQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRK

--------------------------------------------------------------
>30166_30166_6_FGD4-FAU_FGD4_chr12_32764108_ENST00000534526_FAU_chr11_64888268_ENST00000531743_length(transcript)=2143nt_BP=1976nt
GGTAGCGGCTTTGAGTGAGTGCGGGAGCTGCAGATACCGAGACGCTGCGACTGCCGCAGGAGTCGCCGCAGCCAAACTCGCCGCGACGCC
GGGAGGGAGCGTACCGGGAAGGAGAGGGAGAGGAGGCACTCGCTGAGGAGACGCCGCAGTAGAGGGCGCCCCCGGAGTCGCGCCGAACCT
GGGCATGCAGGCGACGCCCCCCAGGGGCCGCTCGCGGCTGGACGGGAGCGGGAGGAGTCGGGGAGCGGCGGTCGAGCCCGGCAGGATGAG
CGACGAGGGCGGCTCCAACTTCAGGCGGGTGGCGATCCGGCGGAAGTCCAACCCCTCCTACCTGCCGCCCGGGGTGCCCCGGCCCTGGAG
CAGGCCCGCGTCGCACCTGGGACGTGTAGGGACCGCTGCCTTCAAGGGCCAGGTGCCCTCAGGAGCCACAGGCAGCAGTACCTGTCCAAA
GATCGCTTTAGTTCCACCTTGCTCCACAAGCAGCACAACCACACTGGTTGGTGAGAATGTATCTGAAGAAGAGGCTCAGGGAATAAATGG
GAACAGGCCAGCAAAACACTCAGCTGCAAGTCCAAAGCCACAAGTGCCTCCAAAGCCATTACACCTGCAGAATTCACCTTCGTCCAATAT
ACACCAAACCCCCAGGCATAAAGCTTTACCTAGTGCAAAACCAAGGATGGAGGAAATTAAACCTGCCTCTGCTTCTTGTGTCTCAAAAGA
AAAACCCAGTAAGGTATCAGATCTCATCAGTCGCTTTGAAGGAGGCAGCTCATTATCAAATTATAGTGATTTGAAGAAAGAGTCTGCTGT
GAACCTAAATGCTCCTAGAACCCCAGGAAGGCATGGATTGACAACCACACCTCAACAAAAACTCCTCTCCCAGCACTTGCCACAGAGGCA
GGGAAATGATACAGATAAGACTCAGGGTGCACAGACTTGTGTGGCCAACGGTGTAATGGCAGCACAAAACCAGATGGAATGTGAGGAGGA
GAAAGCTGCCACTCTTAGCTCAGATACTTCTATTCAAGCTTCTGAACCCTTGCTTGATACGCACATAGTGAATGGAGAAAGAGATGAAAC
TGCCACAGCTCCTGCATCACCCACAACAGACAGCTGTGATGGAAATGCTTCTGACAGTAGCTACAGGACTCCAGGCATAGGCCCAGTGCT
CCCCCTAGAAGAAAGAGGGGCAGAAACAGAAACCAAGGTACAAGAGAGGGAAAATGGGGAAAGCCCTCTGGAACTGGAGCAGCTGGACCA
GCACCATGAGATGAAGGAGACTAATGAGCAAAAACTTCACAAAATAGCCAATGAACTTTTGCTTACTGAAAGAGCTTATGTCAACCGACT
TGACCTCTTAGATCAGGTATTTTATTGCAAACTGTTGGAAGAAGCAAACCGAGGCTCGTTTCCAGCAGAGATGGTGAATAAAATCTTTTC
TAATATTTCATCAATAAATGCCTTCCATAGTAAATTCCTCTTGCCAGAGCTGGAGAAACGAATGCAAGAATGGGAAACTACTCCTAGAAT
TGGAGACATCCTTCAGAAATTGGCACCATTCCTTAAGATGTATGGAGAATATGTGAAAGGATTTGATAATGCAATGGAATTGGTTAAAAA
CATGACAGAACGTATTCCCCAGTTCAAATCAGTGGTTGAAGAAATTCAGAAACAGAAAATCTGTGGGAGCTTAACTTTGCAGCATCACAT
GCTAGAACCTGTTCAGCGGATTCCCCGGTATGAGATGCTCCTTAAGGACTATCTAAGGAAATTGCCTCCTGATTCCCTGGACTGGAATGA
TGCTAAAAAATCACTTGAAATTATATCTACAGCAGCAAGCCATTCTAATAGTGCAATAAGGAAAATGGGGAGAAGAAGAAGACATTGTAA
ACCCTTCAAATGAACTAATAAAAGAAGGACAGATCCTCAAACTAGCTGCTCGGAACACTTCAGCACAAGAACGCTACCTTTTCTTAAGGA
GAAGAAGAAGAAGAAGACAGGTCGGGCTAAGCGGCGGATGCAGTACAACCGGCGCTTTGTCAACGTTGTGCCCACCTTTGGCAAGAAGAA

>30166_30166_6_FGD4-FAU_FGD4_chr12_32764108_ENST00000534526_FAU_chr11_64888268_ENST00000531743_length(amino acids)=574AA_BP=
MGMQATPPRGRSRLDGSGRSRGAAVEPGRMSDEGGSNFRRVAIRRKSNPSYLPPGVPRPWSRPASHLGRVGTAAFKGQVPSGATGSSTCP
KIALVPPCSTSSTTTLVGENVSEEEAQGINGNRPAKHSAASPKPQVPPKPLHLQNSPSSNIHQTPRHKALPSAKPRMEEIKPASASCVSK
EKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEE
EKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLD
QHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPR
IGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWN

--------------------------------------------------------------
>30166_30166_7_FGD4-FAU_FGD4_chr12_32764108_ENST00000546442_FAU_chr11_64888268_ENST00000531743_length(transcript)=1683nt_BP=1516nt
GGGGAAAGCAGGGGAGCCTGTGCTGGGTGAGATTATCTGCAATGGACCGGGTTAATGGGAGGCTTGCTTTGGCTCGCTGGAAGAACAAAT
GAAGGGAGTTTTACTTCAACCATTTGTGACTTCTGGCCAAGAGGAATAAATTCAGCTTTTATAAGGCAGCAGTACCTGTCCAAAGATCGC
TTTAGTTCCACCTTGCTCCACAAGCAGCACAACCACACTGGTTGGTGAGAATGTATCTGAAGAAGAGGCTCAGGGAATAAATGGGAACAG
GCCAGCAAAACACTCAGCTGCAAGTCCAAAGCCACAAGCTCATTATCAAATTATAGTGATTTGAAGAAAGAGTCTGCTGTGAACCTAAAT
GCTCCTAGAACCCCAGGAAGGCATGGATTGACAACCACACCTCAACAAAAACTCCTCTCCCAGCACTTGCCACAGAGGCAGGGAAATGAT
ACAGATAAGACTCAGGGTGCACAGACTTGTGTGGCCAACGGTGTAATGGCAGCACAAAACCAGATGGAATGTGAGGAGGAGAAAGCTGCC
ACTCTTAGCTCAGATACTTCTATTCAAGCTTCTGAACCCTTGCTTGATACGCACATAGTGAATGGAGAAAGAGATGAAACTGCCACAGCT
CCTGCATCACCCACAACAGACAGCTGTGATGGAAATGCTTCTGACAGTAGCTACAGGACTCCAGGCATAGGCCCAGTGCTCCCCCTAGAA
GAAAGAGGGGCAGAAACAGAAACCAAGGTACAAGAGAGGGAAAATGGGGAAAGCCCTCTGGAACTGGAGCAGCTGGACCAGCACCATGAG
ATGAAGGAGACTAATGAGCAAAAACTTCACAAAATAGCCAATGAACTTTTGCTTACTGAAAGAGCTTATGTCAACCGACTTGACCTCTTA
GATCAGGTATTTTATTGCAAACTGTTGGAAGAAGCAAACCGAGGCTCGTTTCCAGCAGAGATGGTGAATAAAATCTTTTCTAATATTTCA
TCAATAAATGCCTTCCATAGTAAATTCCTCTTGCCAGAGCTGGAGAAACGAATGCAAGAATGGGAAACTACTCCTAGAATTGGAGACATC
CTTCAGAAATTGGCACCATTCCTTAAGATGTATGGAGAATATGTGAAAGGATTTGATAATGCAATGGAATTGGTTAAAAACATGACAGAA
CGTATTCCCCAGTTCAAATCAGTGGTTGAAGAAATTCAGAAACAGAAAATCTGTGGGAGCTTAACTTTGCAGCATCACATGCTAGAACCT
GTTCAGCGGATTCCCCGGTATGAGATGCTCCTTAAGGACTATCTAAGGAAATTGCCTCCTGATTCCCTGGACTGGAATGATGCTAAAAAA
TCACTTGAAATTATATCTACAGCAGCAAGCCATTCTAATAGTGCAATAAGGAAAATGGGGAGAAGAAGAAGACATTGTAAACCCTTCAAA
TGAACTAATAAAAGAAGGACAGATCCTCAAACTAGCTGCTCGGAACACTTCAGCACAAGAACGCTACCTTTTCTTAAGGAGAAGAAGAAG
AAGAAGACAGGTCGGGCTAAGCGGCGGATGCAGTACAACCGGCGCTTTGTCAACGTTGTGCCCACCTTTGGCAAGAAGAAGGGCCCCAAT

>30166_30166_7_FGD4-FAU_FGD4_chr12_32764108_ENST00000546442_FAU_chr11_64888268_ENST00000531743_length(amino acids)=370AA_BP=
MKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIV
NGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTE
RAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDN
AMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FGD4-FAU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FGD4-FAU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FGD4-FAU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGD4C1836336CHARCOT-MARIE-TOOTH DISEASE, TYPE 4H3CTD_human;GENOMICS_ENGLAND;UNIPROT