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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FGD4-CCDC91 (FusionGDB2 ID:HG121512TG55297)

Fusion Gene Summary for FGD4-CCDC91

check button Fusion gene summary
Fusion gene informationFusion gene name: FGD4-CCDC91
Fusion gene ID: hg121512tg55297
HgeneTgene
Gene symbol

FGD4

CCDC91

Gene ID

121512

55297

Gene nameFYVE, RhoGEF and PH domain containing 4coiled-coil domain containing 91
SynonymsCMT4H|FRABP|ZFYVE6HSD8|p56
Cytomap('FGD4')('CCDC91')

12p11.21

12p11.22

Type of geneprotein-codingprotein-coding
DescriptionFYVE, RhoGEF and PH domain-containing protein 4FGD1 family, member 4FGD1-related F-actin-binding proteinactin-filament binding protein frabinzinc finger FYVE domain-containing protein 6coiled-coil domain-containing protein 91GGA-binding partnerp56 accessory protein
Modification date2020032820200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000473513, ENST00000266482, 
ENST00000427716, ENST00000472289, 
ENST00000546442, ENST00000381025, 
ENST00000525053, ENST00000531134, 
ENST00000534526, 
Fusion gene scores* DoF score19 X 13 X 13=321115 X 14 X 9=1890
# samples 2217
** MAII scorelog2(22/3211*10)=-3.86744723620111
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(17/1890*10)=-3.47477958297073
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGD4 [Title/Abstract] AND CCDC91 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFGD4(32655272)-CCDC91(28515371), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DU-7007-01AFGD4chr12

32655272

+CCDC91chr12

28515371

+
ChimerDB4LGGTCGA-DU-7007FGD4chr12

32655272

+CCDC91chr12

28515371

+


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Fusion Gene ORF analysis for FGD4-CCDC91

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000473513ENST00000381256FGD4chr12

32655272

+CCDC91chr12

28515371

+
3UTR-3CDSENST00000473513ENST00000381259FGD4chr12

32655272

+CCDC91chr12

28515371

+
3UTR-3CDSENST00000473513ENST00000539107FGD4chr12

32655272

+CCDC91chr12

28515371

+
3UTR-3CDSENST00000473513ENST00000545336FGD4chr12

32655272

+CCDC91chr12

28515371

+
3UTR-3UTRENST00000473513ENST00000306172FGD4chr12

32655272

+CCDC91chr12

28515371

+
3UTR-3UTRENST00000473513ENST00000540401FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3CDSENST00000266482ENST00000381256FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3CDSENST00000266482ENST00000381259FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3CDSENST00000266482ENST00000539107FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3CDSENST00000266482ENST00000545336FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3CDSENST00000427716ENST00000381256FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3CDSENST00000427716ENST00000381259FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3CDSENST00000427716ENST00000539107FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3CDSENST00000427716ENST00000545336FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3CDSENST00000472289ENST00000381256FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3CDSENST00000472289ENST00000381259FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3CDSENST00000472289ENST00000539107FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3CDSENST00000472289ENST00000545336FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3CDSENST00000546442ENST00000381256FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3CDSENST00000546442ENST00000381259FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3CDSENST00000546442ENST00000539107FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3CDSENST00000546442ENST00000545336FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3UTRENST00000266482ENST00000306172FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3UTRENST00000266482ENST00000540401FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3UTRENST00000427716ENST00000306172FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3UTRENST00000427716ENST00000540401FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3UTRENST00000472289ENST00000306172FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3UTRENST00000472289ENST00000540401FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3UTRENST00000546442ENST00000306172FGD4chr12

32655272

+CCDC91chr12

28515371

+
5UTR-3UTRENST00000546442ENST00000540401FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3CDSENST00000381025ENST00000381256FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3CDSENST00000381025ENST00000381259FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3CDSENST00000381025ENST00000539107FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3CDSENST00000381025ENST00000545336FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3CDSENST00000525053ENST00000381256FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3CDSENST00000525053ENST00000381259FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3CDSENST00000525053ENST00000539107FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3CDSENST00000525053ENST00000545336FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3CDSENST00000531134ENST00000381256FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3CDSENST00000531134ENST00000381259FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3CDSENST00000531134ENST00000539107FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3CDSENST00000531134ENST00000545336FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3CDSENST00000534526ENST00000381256FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3CDSENST00000534526ENST00000381259FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3CDSENST00000534526ENST00000539107FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3CDSENST00000534526ENST00000545336FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3UTRENST00000381025ENST00000306172FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3UTRENST00000381025ENST00000540401FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3UTRENST00000525053ENST00000306172FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3UTRENST00000525053ENST00000540401FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3UTRENST00000531134ENST00000306172FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3UTRENST00000531134ENST00000540401FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3UTRENST00000534526ENST00000306172FGD4chr12

32655272

+CCDC91chr12

28515371

+
intron-3UTRENST00000534526ENST00000540401FGD4chr12

32655272

+CCDC91chr12

28515371

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FGD4-CCDC91


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FGD4chr1232655272+CCDC91chr1228515370+6.93E-091
FGD4chr1232655272+CCDC91chr1228515370+6.93E-091
FGD4chr1232655272+CCDC91chr1228515370+6.93E-091
FGD4chr1232655272+CCDC91chr1228515370+6.93E-091


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FGD4-CCDC91


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:32655272/:28515371)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FGD4-CCDC91


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FGD4-CCDC91


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FGD4-CCDC91


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FGD4-CCDC91


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGD4C1836336CHARCOT-MARIE-TOOTH DISEASE, TYPE 4H3CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0013146Drug abuse1CTD_human
TgeneC0013170Drug habituation1CTD_human
TgeneC0013222Drug Use Disorders1CTD_human
TgeneC0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgeneC0038580Substance Dependence1CTD_human
TgeneC0038586Substance Use Disorders1CTD_human
TgeneC0236969Substance-Related Disorders1CTD_human
TgeneC0740858Substance abuse problem1CTD_human
TgeneC1510472Drug Dependence1CTD_human
TgeneC4316881Prescription Drug Abuse1CTD_human