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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:AEBP2-GYS2 (FusionGDB2 ID:HG121536TG2998) |
Fusion Gene Summary for AEBP2-GYS2 |
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Fusion gene information | Fusion gene name: AEBP2-GYS2 | Fusion gene ID: hg121536tg2998 | Hgene | Tgene | Gene symbol | AEBP2 | GYS2 | Gene ID | 121536 | 2998 |
Gene name | AE binding protein 2 | glycogen synthase 2 | |
Synonyms | - | - | |
Cytomap | ('AEBP2')('GYS2') 12p12.3 | 12p12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein AEBP2AE(adipocyte enhancer)-binding protein 2adipocyte enhancer-binding protein 2 | glycogen [starch] synthase, liverglycogen synthase 2 (liver) | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q6ZN18 | P54840 | |
Ensembl transtripts involved in fusion gene | ENST00000266508, ENST00000360995, ENST00000398864, ENST00000541908, | ||
Fusion gene scores | * DoF score | 10 X 9 X 8=720 | 8 X 7 X 5=280 |
# samples | 12 | 8 | |
** MAII score | log2(12/720*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: AEBP2 [Title/Abstract] AND GYS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | AEBP2(19646920)-GYS2(21699404), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | AEBP2-GYS2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. AEBP2-GYS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. AEBP2-GYS2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. AEBP2-GYS2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | GYS2 | GO:0005978 | glycogen biosynthetic process | 1731614 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | HNSC | TCGA-F7-A50G-01A | AEBP2 | chr12 | 19646920 | - | GYS2 | chr12 | 21699404 | - |
ChimerDB4 | HNSC | TCGA-F7-A50G-01A | AEBP2 | chr12 | 19646920 | + | GYS2 | chr12 | 21699404 | - |
ChimerDB4 | HNSC | TCGA-F7-A50G | AEBP2 | chr12 | 19646920 | + | GYS2 | chr12 | 21699404 | - |
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Fusion Gene ORF analysis for AEBP2-GYS2 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000266508 | ENST00000261195 | AEBP2 | chr12 | 19646920 | + | GYS2 | chr12 | 21699404 | - |
Frame-shift | ENST00000360995 | ENST00000261195 | AEBP2 | chr12 | 19646920 | + | GYS2 | chr12 | 21699404 | - |
Frame-shift | ENST00000398864 | ENST00000261195 | AEBP2 | chr12 | 19646920 | + | GYS2 | chr12 | 21699404 | - |
Frame-shift | ENST00000541908 | ENST00000261195 | AEBP2 | chr12 | 19646920 | + | GYS2 | chr12 | 21699404 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for AEBP2-GYS2 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for AEBP2-GYS2 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:19646920/:21699404) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
AEBP2 | GYS2 |
FUNCTION: Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:31959557, PubMed:29499137). Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137). {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. | FUNCTION: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for AEBP2-GYS2 |
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Fusion Gene PPI Analysis for AEBP2-GYS2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for AEBP2-GYS2 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for AEBP2-GYS2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C1855861 | Glycogen Storage Disease 0, Liver | 2 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C0017919 | Glycogen Storage Disease | 1 | GENOMICS_ENGLAND | |
Tgene | C2239176 | Liver carcinoma | 1 | CTD_human |