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	Fusion Gene Summary
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Fusion gene:ACSM2A-ABCC6 (FusionGDB2 ID:HG123876TG368)

Fusion Gene Summary for ACSM2A-ABCC6

Fusion gene summary

Fusion gene information	Fusion gene name: ACSM2A-ABCC6
	Fusion gene ID: hg123876tg368
		Hgene	Tgene
	Gene symbol	ACSM2A	ABCC6
	Gene ID	123876	368
	Gene name	acyl-CoA synthetase medium chain family member 2A	ATP binding cassette subfamily C member 6
	Synonyms	A-923A4.1\|ACSM2	ABC34\|ARA\|EST349056\|GACI2\|MLP1\|MOAT-E\|MOATE\|MRP6\|PXE\|PXE1\|URG7
	Cytomap	('ACSM2A')('ABCC6') 16p12.3	16p13.11
	Type of gene	protein-coding	protein-coding
	Description	acyl-coenzyme A synthetase ACSM2A, mitochondrialacyl-CoA synthetase medium-chain family member 2benzoate--CoA ligasebutyrate--CoA ligase 2Abutyryl-coenzyme A synthetase 2Amiddle-chain acyl-CoA synthetase 2A	multidrug resistance-associated protein 6URG7 proteinATP-binding cassette, sub-family C (CFTR/MRP), member 6anthracycline resistance-associated proteinmulti-specific organic anion transporter E
	Modification date	20200320	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000575558, ENST00000219054, ENST00000396104, ENST00000417235, ENST00000536134, ENST00000573854, ENST00000575690, ENST00000424070,
Fusion gene scores	* DoF score	2 X 2 X 2=8	1 X 1 X 1=1
	# samples	2	1
	** MAII score	log2(2/8*10)=1.32192809488736	log2(1/1*10)=3.32192809488736
Context	PubMed: ACSM2A [Title/Abstract] AND ABCC6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ACSM2A(20492243)-ABCC6(16263710), # samples:1
Anticipated loss of major functional domain due to fusion event.	ACSM2A-ABCC6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACSM2A-ABCC6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACSM2A-ABCC6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ACSM2A-ABCC6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ACSM2A	GO:0036112	medium-chain fatty-acyl-CoA metabolic process	19345228

Fusion gene breakpoints across ACSM2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ABCC6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KIRC	TCGA-BP-4801-01A	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-

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Fusion Gene ORF analysis for ACSM2A-ABCC6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000575558	ENST00000205557	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-
3UTR-intron	ENST00000575558	ENST00000574094	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-
3UTR-intron	ENST00000575558	ENST00000575728	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-
5CDS-intron	ENST00000219054	ENST00000574094	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-
5CDS-intron	ENST00000219054	ENST00000575728	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-
5CDS-intron	ENST00000396104	ENST00000574094	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-
5CDS-intron	ENST00000396104	ENST00000575728	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-
5CDS-intron	ENST00000417235	ENST00000574094	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-
5CDS-intron	ENST00000417235	ENST00000575728	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-
5CDS-intron	ENST00000536134	ENST00000574094	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-
5CDS-intron	ENST00000536134	ENST00000575728	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-
5CDS-intron	ENST00000573854	ENST00000574094	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-
5CDS-intron	ENST00000573854	ENST00000575728	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-
5CDS-intron	ENST00000575690	ENST00000574094	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-
5CDS-intron	ENST00000575690	ENST00000575728	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-
In-frame	ENST00000219054	ENST00000205557	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-
In-frame	ENST00000396104	ENST00000205557	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-
In-frame	ENST00000417235	ENST00000205557	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-
In-frame	ENST00000536134	ENST00000205557	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-
In-frame	ENST00000573854	ENST00000205557	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-
In-frame	ENST00000575690	ENST00000205557	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-
intron-3CDS	ENST00000424070	ENST00000205557	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-
intron-intron	ENST00000424070	ENST00000574094	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-
intron-intron	ENST00000424070	ENST00000575728	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000417235	ACSM2A	chr16	20492243	+	ENST00000205557	ABCC6	chr16	16263710	-	4372	1442	2	3166	1054
ENST00000536134	ACSM2A	chr16	20492243	+	ENST00000205557	ABCC6	chr16	16263710	-	4464	1534	709	3258	849
ENST00000573854	ACSM2A	chr16	20492243	+	ENST00000205557	ABCC6	chr16	16263710	-	4553	1623	99	3347	1082
ENST00000219054	ACSM2A	chr16	20492243	+	ENST00000205557	ABCC6	chr16	16263710	-	4580	1650	135	3374	1079
ENST00000575690	ACSM2A	chr16	20492243	+	ENST00000205557	ABCC6	chr16	16263710	-	4909	1979	464	3703	1079
ENST00000396104	ACSM2A	chr16	20492243	+	ENST00000205557	ABCC6	chr16	16263710	-	4450	1520	5	3244	1079

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000417235	ENST00000205557	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-	0.002385658	0.9976144
ENST00000536134	ENST00000205557	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-	0.004238715	0.99576133
ENST00000573854	ENST00000205557	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-	0.002695883	0.9973041
ENST00000219054	ENST00000205557	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-	0.002889441	0.9971105
ENST00000575690	ENST00000205557	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-	0.003414369	0.9965856
ENST00000396104	ENST00000205557	ACSM2A	chr16	20492243	+	ABCC6	chr16	16263710	-	0.002401659	0.99759835

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Fusion Genomic Features for ACSM2A-ABCC6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for ACSM2A-ABCC6

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:20492243/chr16:16263710)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ACSM2A

chr16:20492243

chr16:16263710

ENST00000219054

221_229

503

578.0

Nucleotide binding

ATP

Hgene

ACSM2A

chr16:20492243

chr16:16263710

ENST00000219054

359_364

503

578.0

Nucleotide binding

ATP

Hgene

ACSM2A

chr16:20492243

chr16:16263710

ENST00000396104

221_229

503

578.0

Nucleotide binding

ATP

Hgene

ACSM2A

chr16:20492243

chr16:16263710

ENST00000396104

359_364

503

578.0

Nucleotide binding

ATP

Hgene

ACSM2A

chr16:20492243

chr16:16263710

ENST00000573854

221_229

503

578.0

Nucleotide binding

ATP

Hgene

ACSM2A

chr16:20492243

chr16:16263710

ENST00000573854

359_364

503

578.0

Nucleotide binding

ATP

Hgene

ACSM2A

chr16:20492243

chr16:16263710

ENST00000575690

221_229

503

578.0

Nucleotide binding

ATP

Hgene

ACSM2A

chr16:20492243

chr16:16263710

ENST00000575690

359_364

503

578.0

Nucleotide binding

ATP

Hgene

ACSM2A

chr16:20492243

chr16:16263710

ENST00000219054

469_471

503

578.0

Region

Coenzyme A binding

Hgene

ACSM2A

chr16:20492243

chr16:16263710

ENST00000396104

469_471

503

578.0

Region

Coenzyme A binding

Hgene

ACSM2A

chr16:20492243

chr16:16263710

ENST00000573854

469_471

503

578.0

Region

Coenzyme A binding

Hgene

ACSM2A

chr16:20492243

chr16:16263710

ENST00000575690

469_471

503

578.0

Region

Coenzyme A binding

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

1265_1499

929

1504.0

Domain

ABC transporter 2

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

947_1228

929

1504.0

Domain

ABC transmembrane type-1 2

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

1265_1499

100.0

Domain

ABC transporter 2

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

311_593

100.0

Domain

ABC transmembrane type-1 1

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

629_853

100.0

Domain

ABC transporter 1

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

947_1228

100.0

Domain

ABC transmembrane type-1 2

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

1299_1306

929

1504.0

Nucleotide binding

ATP 2

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

1299_1306

100.0

Nucleotide binding

ATP 2

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

663_670

100.0

Nucleotide binding

ATP 1

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

1019_1061

929

1504.0

Topological domain

Cytoplasmic

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

1083_1083

929

1504.0

Topological domain

Extracellular

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

1105_1175

929

1504.0

Topological domain

Cytoplasmic

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

1197_1198

929

1504.0

Topological domain

Extracellular

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

1220_1503

929

1504.0

Topological domain

Cytoplasmic

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

961_997

929

1504.0

Topological domain

Extracellular

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

1019_1061

100.0

Topological domain

Cytoplasmic

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

1083_1083

100.0

Topological domain

Extracellular

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

1105_1175

100.0

Topological domain

Cytoplasmic

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

1197_1198

100.0

Topological domain

Extracellular

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

120_131

100.0

Topological domain

Cytoplasmic

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

1220_1503

100.0

Topological domain

Cytoplasmic

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

150_167

100.0

Topological domain

Extracellular

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

189_302

100.0

Topological domain

Cytoplasmic

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

1_31

100.0

Topological domain

Extracellular

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

324_349

100.0

Topological domain

Extracellular

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

371_426

100.0

Topological domain

Cytoplasmic

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

448_450

100.0

Topological domain

Extracellular

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

472_533

100.0

Topological domain

Cytoplasmic

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

53_72

100.0

Topological domain

Cytoplasmic

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

555_575

100.0

Topological domain

Extracellular

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

597_939

100.0

Topological domain

Cytoplasmic

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

94_98

100.0

Topological domain

Extracellular

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

961_997

100.0

Topological domain

Extracellular

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

1062_1082

929

1504.0

Transmembrane

Helical%3B Name%3D14

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

1084_1104

929

1504.0

Transmembrane

Helical%3B Name%3D15

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

1176_1196

929

1504.0

Transmembrane

Helical%3B Name%3D16

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

1199_1219

929

1504.0

Transmembrane

Helical%3B Name%3D17

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

940_960

929

1504.0

Transmembrane

Helical%3B Name%3D12

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

998_1018

929

1504.0

Transmembrane

Helical%3B Name%3D13

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

1062_1082

100.0

Transmembrane

Helical%3B Name%3D14

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

1084_1104

100.0

Transmembrane

Helical%3B Name%3D15

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

1176_1196

100.0

Transmembrane

Helical%3B Name%3D16

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

1199_1219

100.0

Transmembrane

Helical%3B Name%3D17

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

132_149

100.0

Transmembrane

Helical%3B Name%3D4

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

168_188

100.0

Transmembrane

Helical%3B Name%3D5

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

303_323

100.0

Transmembrane

Helical%3B Name%3D6

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

32_52

100.0

Transmembrane

Helical%3B Name%3D1

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

350_370

100.0

Transmembrane

Helical%3B Name%3D7

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

427_447

100.0

Transmembrane

Helical%3B Name%3D8

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

451_471

100.0

Transmembrane

Helical%3B Name%3D9

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

534_554

100.0

Transmembrane

Helical%3B Name%3D10

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

576_596

100.0

Transmembrane

Helical%3B Name%3D11

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

73_93

100.0

Transmembrane

Helical%3B Name%3D2

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

940_960

100.0

Transmembrane

Helical%3B Name%3D12

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

998_1018

100.0

Transmembrane

Helical%3B Name%3D13

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000575728

99_119

100.0

Transmembrane

Helical%3B Name%3D3

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ACSM2A

chr16:20492243

chr16:16263710

ENST00000219054

540_542

503

578.0

Region

Coenzyme A binding

Hgene

ACSM2A

chr16:20492243

chr16:16263710

ENST00000396104

540_542

503

578.0

Region

Coenzyme A binding

Hgene

ACSM2A

chr16:20492243

chr16:16263710

ENST00000573854

540_542

503

578.0

Region

Coenzyme A binding

Hgene

ACSM2A

chr16:20492243

chr16:16263710

ENST00000575690

540_542

503

578.0

Region

Coenzyme A binding

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

311_593

929

1504.0

Domain

ABC transmembrane type-1 1

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

629_853

929

1504.0

Domain

ABC transporter 1

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

663_670

929

1504.0

Nucleotide binding

ATP 1

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

120_131

929

1504.0

Topological domain

Cytoplasmic

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

150_167

929

1504.0

Topological domain

Extracellular

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

189_302

929

1504.0

Topological domain

Cytoplasmic

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

1_31

929

1504.0

Topological domain

Extracellular

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

324_349

929

1504.0

Topological domain

Extracellular

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

371_426

929

1504.0

Topological domain

Cytoplasmic

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

448_450

929

1504.0

Topological domain

Extracellular

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

472_533

929

1504.0

Topological domain

Cytoplasmic

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

53_72

929

1504.0

Topological domain

Cytoplasmic

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

555_575

929

1504.0

Topological domain

Extracellular

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

597_939

929

1504.0

Topological domain

Cytoplasmic

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

94_98

929

1504.0

Topological domain

Extracellular

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

132_149

929

1504.0

Transmembrane

Helical%3B Name%3D4

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

168_188

929

1504.0

Transmembrane

Helical%3B Name%3D5

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

303_323

929

1504.0

Transmembrane

Helical%3B Name%3D6

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

32_52

929

1504.0

Transmembrane

Helical%3B Name%3D1

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

350_370

929

1504.0

Transmembrane

Helical%3B Name%3D7

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

427_447

929

1504.0

Transmembrane

Helical%3B Name%3D8

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

451_471

929

1504.0

Transmembrane

Helical%3B Name%3D9

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

534_554

929

1504.0

Transmembrane

Helical%3B Name%3D10

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

576_596

929

1504.0

Transmembrane

Helical%3B Name%3D11

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

73_93

929

1504.0

Transmembrane

Helical%3B Name%3D2

Tgene

ABCC6

chr16:20492243

chr16:16263710

ENST00000205557

99_119

929

1504.0

Transmembrane

Helical%3B Name%3D3

Top

Fusion Gene Sequence for ACSM2A-ABCC6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>1525_1525_1_ACSM2A-ABCC6_ACSM2A_chr16_20492243_ENST00000219054_ABCC6_chr16_16263710_ENST00000205557_length(transcript)=4580nt_BP=1650nt
GTGCTCTCTTCCAAGGCTGTAGGAGTTCTGGAGCTGCTGGCTGGAGAGGAGGGTGGACGAAGCTCTCTCTAGAAAGACATCCTGAGAGGA
CTTGGCAGCCTGCAGATGGCCTATTGTGGGACCTTGTGATCATGCCTGAATATGCATTGGCTGCGAAAAGTTCAGGGACTTTGCACCCTG
TGGGGTACTCAGATGTCCAGCCGCACTCTCTACATTAATAGTAGGCAACTGGTGTCCCTGCAGTGGGGCCACCAGGAAGTGCCGGCCAAG
TTTAACTTTGCTAGTGATGTGTTGGATCACTGGGCTGACATGGAGAAGGCTGGCAAGCGACTCCCAAGCCCAGCCCTGTGGTGGGTGAAT
GGGAAGGGGAAGGAATTAATGTGGAATTTCAGAGAACTGAGTGAAAACAGCCAGCAGGCAGCCAACGTCCTCTCGGGAGCCTGTGGCCTG
CAGCGTGGGGATCGTGTGGCAGTGGTGCTGCCCCGAGTGCCTGAGTGGTGGCTGGTGATCCTGGGCTGCATTCGAGCAGGTCTCATCTTT
ATGCCTGGAACCATCCAGATGAAATCCACTGACATACTGTATAGGTTGCAGATGTCTAAGGCCAAGGCTATTGTTGCTGGGGATGAAGTC
ATCCAAGAAGTGGACACAGTGGCATCTGAATGTCCTTCTCTGAGAATTAAGCTACTGGTGTCTGAGAAAAGCTGTGATGGGTGGCTGAAC
TTCAAGAAACTACTAAATGAGGCATCCACCACTCATCACTGTGTGGAGACTGGAAGCCAGGAAGCATCTGCCATCTACTTCACTAGTGGG
ACCAGTGGTCTTCCCAAGATGGCAGAACATTCCTACTCGAGCCTGGGCCTCAAGGCCAAGATGGATGCTGGTTGGACAGGCCTGCAAGCC
TCTGATATAATGTGGACCATATCAGACACAGGTTGGATACTGAACATCTTGTGCTCACTTATGGAACCTTGGGCATTAGGAGCATGCACA
TTTGTTCATCTCTTGCCAAAGTTTGACCCACTGGTTATTCTAAAGACACTCTCCAGTTATCCAATCAAGAGTATGATGGGTGCCCCCATT
GTTTACCGGATGTTGCTACAGCAGGATCTTTCCAGTTACAAGTTCCCCCATCTACAGAACTGCGTCACTGTAGGGGAGTCCCTTCTTCCA
GAAACTCTGGAGAACTGGAGGGCCCAGACAGGACTGGACATCCGAGAATCCTATGGCCAGACAGAAACGGGATTAACTTGCATGGTTTCC
AAGACAATGAAAATCAAACCAGGATACATGGGAACGGCTGCTTCCTGTTATGATGTACAGATCATAGATGATAAGGGCAACGTCCTGCCC
CCCGGCACAGAAGGAGACATTGGCATCAGGGTCAAACCCATCAGGCCTATAGGCATCTTCTCTGGCTATGTGGACAATCCCGACAAGACA
GCAGCCAACATTCGAGGAGACTTTTGGCTCCTTGGAGACCGGGGAATCAAAGATGAAGATGGGTATTTCCAGTTTATGGGACGGGCAAAT
GATATCATTAACTCCAGCGGGTACCGGATTGGACCCTCGGAGGTAGAGAATGCACTGATGGAGCACCCTGCTGTGGTTGAGACGGCTGTG
ATCAGCAGCCCAGACCCCGTCCGAGGAGAGGTGAAGGCCACAGTGCACCTGGCCTACCTGCGTGCCGTGGGCACCCCCCTCTGCCTCTAC
GCACTCTTCCTCTTCCTCTGCCAGCAAGTGGCCTCCTTCTGCCGGGGCTACTGGCTGAGCCTGTGGGCGGACGACCCTGCAGTAGGTGGG
CAGCAGACGCAGGCAGCCCTGCGTGGCGGGATCTTCGGGCTCCTCGGCTGTCTCCAAGCCATTGGGCTGTTTGCCTCCATGGCTGCGGTG
CTCCTAGGTGGGGCCCGGGCATCCAGGTTGCTCTTCCAGAGGCTCCTGTGGGATGTGGTGCGATCTCCCATCAGCTTCTTTGAGCGGACA
CCCATTGGTCACCTGCTAAACCGCTTCTCCAAGGAGACAGACACGGTTGACGTGGACATTCCAGACAAACTCCGGTCCCTGCTGATGTAC
GCCTTTGGACTCCTGGAGGTCAGCCTGGTGGTGGCAGTGGCTACCCCACTGGCCACTGTGGCCATCCTGCCACTGTTTCTCCTCTACGCT
GGGTTTCAGAGCCTGTATGTGGTTAGCTCATGCCAGCTGAGACGCTTGGAGTCAGCCAGCTACTCGTCTGTCTGCTCCCACATGGCTGAG
ACGTTCCAGGGCAGCACAGTGGTCCGGGCATTCCGAACCCAGGCCCCCTTTGTGGCTCAGAACAATGCTCGCGTAGATGAAAGCCAGAGG
ATCAGTTTCCCGCGACTGGTGGCTGACAGGTGGCTTGCGGCCAATGTGGAGCTCCTGGGGAATGGCCTGGTGTTTGCAGCTGCCACGTGT
GCTGTGCTGAGCAAAGCCCACCTCAGTGCTGGCCTCGTGGGCTTCTCTGTCTCTGCTGCCCTCCAGGTGACCCAGACACTGCAGTGGGTT
GTTCGCAACTGGACAGACCTAGAGAACAGCATCGTGTCAGTGGAGCGGATGCAGGACTATGCCTGGACGCCCAAGGAGGCTCCCTGGAGG
CTGCCCACATGTGCAGCTCAGCCCCCCTGGCCTCAGGGCGGGCAGATCGAGTTCCGGGACTTTGGGCTAAGATACCGACCTGAGCTCCCG
CTGGCTGTGCAGGGCGTGTCCTTCAAGATCCACGCAGGAGAGAAGGTGGGCATCGTTGGCAGGACCGGGGCAGGGAAGTCCTCCCTGGCC
AGTGGGCTGCTGCGGCTCCAGGAGGCAGCTGAGGGTGGGATCTGGATCGACGGGGTCCCCATTGCCCACGTGGGGCTGCACACACTGCGC
TCCAGGATCAGCATCATCCCCCAGGACCCCATCCTGTTCCCTGGCTCTCTGCGGATGAACCTCGACCTGCTGCAGGAGCACTCGGACGAG
GCTATCTGGGCAGCCCTGGAGACGGTGCAGCTCAAAGCCTTGGTGGCCAGCCTGCCCGGCCAGCTGCAGTACAAGTGTGCTGACCGAGGC
GAGGACCTGAGCGTGGGCCAGAAACAGCTCCTGTGTCTGGCACGTGCCCTTCTCCGGAAGACCCAGATCCTCATCCTGGACGAGGCTACT
GCTGCCGTGGACCCTGGCACGGAGCTGCAGATGCAGGCCATGCTCGGGAGCTGGTTTGCACAGTGCACTGTGCTGCTCATTGCCCACCGC
CTGCGCTCCGTGATGGACTGTGCCCGGGTTCTGGTCATGGACAAGGGGCAGGTGGCAGAGAGCGGCAGCCCGGCCCAGCTGCTGGCCCAG
AAGGGCCTGTTTTACAGACTGGCCCAGGAGTCAGGCCTGGTCTGAGCCAGGACCCTCAACCGTACCCCAGTTGGACCAGCCCGCACAGCC
TGCAGTGCTGGAGATGGAAGTGACCCGTGGTCATCGATAGCTCCACACGATATTGAGTCTAGACCTGTGTTTGCTCTCTGGGAGGAAAAT
GGCAGAGAAAGTGGCCAATTATCACAGAGCATCAGAGCCGGAAGGACCTAGCAATACACAGGTCTGCCCGGGCAGGGCCCATCTCGCCCT
GTCCACCCTGCAGCCAATGTCAACAGCGACTCTCAGCCCCGCTGTACTCTGGACTCACCTGGGGGCCTCAAGCACATGCCCAGGCTCCCG
GCTAGACCCTTAAATCAGAATCTCTGAGGCTGGGAACTGCCATGCTGTGTGTACTTTTTACAAATTAACACTTTTATTTTGGGATAATCC
CAGACTCACATGCAGTTAAAGAAACAATAATATAGAGAGATTCGTGTACTTGGTACCCCATTTCACCCAATGGTAACATCTTGCAAAACT
CTAGGATAAAGCATCACAGCCAGGGTGTTGACATTGACACAACAATCTTGCTCGATTTCCCGTTTTACCTGTACTCCTGTGTGTGTGTGT
GTTTATTTTGTCCCATGCAGTTTTATCACACATGTAGGCTCATGAATCCACACCAGGGTGAGGATACGGAATAGCCACCACCATTTTCCG
ACCACACCCATCACTCTCGCTCCTGCCCCCAGTGACCATGCTCTGTTCTCCAGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTT
TTTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTTGCTCAGGCTGGAGTGCAGTGGCTCAATCTCAGCTCACTGCAACCTCCACATCC
TGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGTGCAGCTGAGATTACAGGCGTGCGCCACCATGCCTGGCTAACTTGTGTAATTTTTA
TTAGATACGAGGTTTCAGCATATTGGCCAGGCTGGTCTTGAACTCCTGGCCTCATGTGATCCACCCTCCTCGGCCTCCCAAAGTGTTGGG
ATAACAGGCGTGAGCTACCGCACCTGGCCGAGTTTGGTGTATAATTTTAAAGCTCCCCCATAGGATTCCAATGTGCGGCCAGGACTGAGA

>1525_1525_1_ACSM2A-ABCC6_ACSM2A_chr16_20492243_ENST00000219054_ABCC6_chr16_16263710_ENST00000205557_length(amino acids)=1079AA_BP=1
MNMHWLRKVQGLCTLWGTQMSSRTLYINSRQLVSLQWGHQEVPAKFNFASDVLDHWADMEKAGKRLPSPALWWVNGKGKELMWNFRELSE
NSQQAANVLSGACGLQRGDRVAVVLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLR
IKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAKMDAGWTGLQASDIMWTISDTGWILN
ILCSLMEPWALGACTFVHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCVTVGESLLPETLENWRAQTGLDIR
ESYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQIIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVDNPDKTAANIRGDFWLLGDRG
IKDEDGYFQFMGRANDIINSSGYRIGPSEVENALMEHPAVVETAVISSPDPVRGEVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCR
GYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDT
VDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQA
PFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVE
RMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIW
IDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLAR

--------------------------------------------------------------
>1525_1525_2_ACSM2A-ABCC6_ACSM2A_chr16_20492243_ENST00000396104_ABCC6_chr16_16263710_ENST00000205557_length(transcript)=4450nt_BP=1520nt
CAGGCCTGAATATGCATTGGCTGCGAAAAGTTCAGGGACTTTGCACCCTGTGGGGTACTCAGATGTCCAGCCGCACTCTCTACATTAATA
GTAGGCAACTGGTGTCCCTGCAGTGGGGCCACCAGGAAGTGCCGGCCAAGTTTAACTTTGCTAGTGATGTGTTGGATCACTGGGCTGACA
TGGAGAAGGCTGGCAAGCGACTCCCAAGCCCAGCCCTGTGGTGGGTGAATGGGAAGGGGAAGGAATTAATGTGGAATTTCAGAGAACTGA
GTGAAAACAGCCAGCAGGCAGCCAACGTCCTCTCGGGAGCCTGTGGCCTGCAGCGTGGGGATCGTGTGGCAGTGGTGCTGCCCCGAGTGC
CTGAGTGGTGGCTGGTGATCCTGGGCTGCATTCGAGCAGGTCTCATCTTTATGCCTGGAACCATCCAGATGAAATCCACTGACATACTGT
ATAGGTTGCAGATGTCTAAGGCCAAGGCTATTGTTGCTGGGGATGAAGTCATCCAAGAAGTGGACACAGTGGCATCTGAATGTCCTTCTC
TGAGAATTAAGCTACTGGTGTCTGAGAAAAGCTGTGATGGGTGGCTGAACTTCAAGAAACTACTAAATGAGGCATCCACCACTCATCACT
GTGTGGAGACTGGAAGCCAGGAAGCATCTGCCATCTACTTCACTAGTGGGACCAGTGGTCTTCCCAAGATGGCAGAACATTCCTACTCGA
GCCTGGGCCTCAAGGCCAAGATGGATGCTGGTTGGACAGGCCTGCAAGCCTCTGATATAATGTGGACCATATCAGACACAGGTTGGATAC
TGAACATCTTGTGCTCACTTATGGAACCTTGGGCATTAGGAGCATGCACATTTGTTCATCTCTTGCCAAAGTTTGACCCACTGGTTATTC
TAAAGACACTCTCCAGTTATCCAATCAAGAGTATGATGGGTGCCCCCATTGTTTACCGGATGTTGCTACAGCAGGATCTTTCCAGTTACA
AGTTCCCCCATCTACAGAACTGCGTCACTGTAGGGGAGTCCCTTCTTCCAGAAACTCTGGAGAACTGGAGGGCCCAGACAGGACTGGACA
TCCGAGAATCCTATGGCCAGACAGAAACGGGATTAACTTGCATGGTTTCCAAGACAATGAAAATCAAACCAGGATACATGGGAACGGCTG
CTTCCTGTTATGATGTACAGATCATAGATGATAAGGGCAACGTCCTGCCCCCCGGCACAGAAGGAGACATTGGCATCAGGGTCAAACCCA
TCAGGCCTATAGGCATCTTCTCTGGCTATGTGGACAATCCCGACAAGACAGCAGCCAACATTCGAGGAGACTTTTGGCTCCTTGGAGACC
GGGGAATCAAAGATGAAGATGGGTATTTCCAGTTTATGGGACGGGCAAATGATATCATTAACTCCAGCGGGTACCGGATTGGACCCTCGG
AGGTAGAGAATGCACTGATGGAGCACCCTGCTGTGGTTGAGACGGCTGTGATCAGCAGCCCAGACCCCGTCCGAGGAGAGGTGAAGGCCA
CAGTGCACCTGGCCTACCTGCGTGCCGTGGGCACCCCCCTCTGCCTCTACGCACTCTTCCTCTTCCTCTGCCAGCAAGTGGCCTCCTTCT
GCCGGGGCTACTGGCTGAGCCTGTGGGCGGACGACCCTGCAGTAGGTGGGCAGCAGACGCAGGCAGCCCTGCGTGGCGGGATCTTCGGGC
TCCTCGGCTGTCTCCAAGCCATTGGGCTGTTTGCCTCCATGGCTGCGGTGCTCCTAGGTGGGGCCCGGGCATCCAGGTTGCTCTTCCAGA
GGCTCCTGTGGGATGTGGTGCGATCTCCCATCAGCTTCTTTGAGCGGACACCCATTGGTCACCTGCTAAACCGCTTCTCCAAGGAGACAG
ACACGGTTGACGTGGACATTCCAGACAAACTCCGGTCCCTGCTGATGTACGCCTTTGGACTCCTGGAGGTCAGCCTGGTGGTGGCAGTGG
CTACCCCACTGGCCACTGTGGCCATCCTGCCACTGTTTCTCCTCTACGCTGGGTTTCAGAGCCTGTATGTGGTTAGCTCATGCCAGCTGA
GACGCTTGGAGTCAGCCAGCTACTCGTCTGTCTGCTCCCACATGGCTGAGACGTTCCAGGGCAGCACAGTGGTCCGGGCATTCCGAACCC
AGGCCCCCTTTGTGGCTCAGAACAATGCTCGCGTAGATGAAAGCCAGAGGATCAGTTTCCCGCGACTGGTGGCTGACAGGTGGCTTGCGG
CCAATGTGGAGCTCCTGGGGAATGGCCTGGTGTTTGCAGCTGCCACGTGTGCTGTGCTGAGCAAAGCCCACCTCAGTGCTGGCCTCGTGG
GCTTCTCTGTCTCTGCTGCCCTCCAGGTGACCCAGACACTGCAGTGGGTTGTTCGCAACTGGACAGACCTAGAGAACAGCATCGTGTCAG
TGGAGCGGATGCAGGACTATGCCTGGACGCCCAAGGAGGCTCCCTGGAGGCTGCCCACATGTGCAGCTCAGCCCCCCTGGCCTCAGGGCG
GGCAGATCGAGTTCCGGGACTTTGGGCTAAGATACCGACCTGAGCTCCCGCTGGCTGTGCAGGGCGTGTCCTTCAAGATCCACGCAGGAG
AGAAGGTGGGCATCGTTGGCAGGACCGGGGCAGGGAAGTCCTCCCTGGCCAGTGGGCTGCTGCGGCTCCAGGAGGCAGCTGAGGGTGGGA
TCTGGATCGACGGGGTCCCCATTGCCCACGTGGGGCTGCACACACTGCGCTCCAGGATCAGCATCATCCCCCAGGACCCCATCCTGTTCC
CTGGCTCTCTGCGGATGAACCTCGACCTGCTGCAGGAGCACTCGGACGAGGCTATCTGGGCAGCCCTGGAGACGGTGCAGCTCAAAGCCT
TGGTGGCCAGCCTGCCCGGCCAGCTGCAGTACAAGTGTGCTGACCGAGGCGAGGACCTGAGCGTGGGCCAGAAACAGCTCCTGTGTCTGG
CACGTGCCCTTCTCCGGAAGACCCAGATCCTCATCCTGGACGAGGCTACTGCTGCCGTGGACCCTGGCACGGAGCTGCAGATGCAGGCCA
TGCTCGGGAGCTGGTTTGCACAGTGCACTGTGCTGCTCATTGCCCACCGCCTGCGCTCCGTGATGGACTGTGCCCGGGTTCTGGTCATGG
ACAAGGGGCAGGTGGCAGAGAGCGGCAGCCCGGCCCAGCTGCTGGCCCAGAAGGGCCTGTTTTACAGACTGGCCCAGGAGTCAGGCCTGG
TCTGAGCCAGGACCCTCAACCGTACCCCAGTTGGACCAGCCCGCACAGCCTGCAGTGCTGGAGATGGAAGTGACCCGTGGTCATCGATAG
CTCCACACGATATTGAGTCTAGACCTGTGTTTGCTCTCTGGGAGGAAAATGGCAGAGAAAGTGGCCAATTATCACAGAGCATCAGAGCCG
GAAGGACCTAGCAATACACAGGTCTGCCCGGGCAGGGCCCATCTCGCCCTGTCCACCCTGCAGCCAATGTCAACAGCGACTCTCAGCCCC
GCTGTACTCTGGACTCACCTGGGGGCCTCAAGCACATGCCCAGGCTCCCGGCTAGACCCTTAAATCAGAATCTCTGAGGCTGGGAACTGC
CATGCTGTGTGTACTTTTTACAAATTAACACTTTTATTTTGGGATAATCCCAGACTCACATGCAGTTAAAGAAACAATAATATAGAGAGA
TTCGTGTACTTGGTACCCCATTTCACCCAATGGTAACATCTTGCAAAACTCTAGGATAAAGCATCACAGCCAGGGTGTTGACATTGACAC
AACAATCTTGCTCGATTTCCCGTTTTACCTGTACTCCTGTGTGTGTGTGTGTTTATTTTGTCCCATGCAGTTTTATCACACATGTAGGCT
CATGAATCCACACCAGGGTGAGGATACGGAATAGCCACCACCATTTTCCGACCACACCCATCACTCTCGCTCCTGCCCCCAGTGACCATG
CTCTGTTCTCCAGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTTGCT
CAGGCTGGAGTGCAGTGGCTCAATCTCAGCTCACTGCAACCTCCACATCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGTGCAGC
TGAGATTACAGGCGTGCGCCACCATGCCTGGCTAACTTGTGTAATTTTTATTAGATACGAGGTTTCAGCATATTGGCCAGGCTGGTCTTG
AACTCCTGGCCTCATGTGATCCACCCTCCTCGGCCTCCCAAAGTGTTGGGATAACAGGCGTGAGCTACCGCACCTGGCCGAGTTTGGTGT
ATAATTTTAAAGCTCCCCCATAGGATTCCAATGTGCGGCCAGGACTGAGAACTACAGCCCTCGCATCTCCTGCTGCTCCTCCTCCCCCAC

>1525_1525_2_ACSM2A-ABCC6_ACSM2A_chr16_20492243_ENST00000396104_ABCC6_chr16_16263710_ENST00000205557_length(amino acids)=1079AA_BP=1
MNMHWLRKVQGLCTLWGTQMSSRTLYINSRQLVSLQWGHQEVPAKFNFASDVLDHWADMEKAGKRLPSPALWWVNGKGKELMWNFRELSE
NSQQAANVLSGACGLQRGDRVAVVLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLR
IKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAKMDAGWTGLQASDIMWTISDTGWILN
ILCSLMEPWALGACTFVHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCVTVGESLLPETLENWRAQTGLDIR
ESYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQIIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVDNPDKTAANIRGDFWLLGDRG
IKDEDGYFQFMGRANDIINSSGYRIGPSEVENALMEHPAVVETAVISSPDPVRGEVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCR
GYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDT
VDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQA
PFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVE
RMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIW
IDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLAR

--------------------------------------------------------------
>1525_1525_3_ACSM2A-ABCC6_ACSM2A_chr16_20492243_ENST00000417235_ABCC6_chr16_16263710_ENST00000205557_length(transcript)=4372nt_BP=1442nt
GCTTGAGTTACTGTGCTCTCTTCCAAGGCTGTAGGAGTTCTGGAGCTGCTGGCTGGAGAGGAGGGTGGACGAAGCTCTCTCTAGAAAGAC
ATCCTGAGAGGACTTGGCAGGCTGGCAAGCGACTCCCAAGCCCAGCCCTGTGGTGGGTGAATGGGAAGGGGAAGGAATTAATGTGGAATT
TCAGAGAACTGAGTGAAAACAGCCAGCAGGCAGCCAACGTCCTCTCGGGAGCCTGTGGCCTGCAGCGTGGGGATCGTGTGGCAGTGGTGC
TGCCCCGAGTGCCTGAGTGGTGGCTGGTGATCCTGGGCTGCATTCGAGCAGGTCTCATCTTTATGCCTGGAACCATCCAGATGAAATCCA
CTGACATACTGTATAGGTTGCAGATGTCTAAGGCCAAGGCTATTGTTGCTGGGGATGAAGTCATCCAAGAAGTGGACACAGTGGCATCTG
AATGTCCTTCTCTGAGAATTAAGCTACTGGTGTCTGAGAAAAGCTGTGATGGGTGGCTGAACTTCAAGAAACTACTAAATGAGGCATCCA
CCACTCATCACTGTGTGGAGACTGGAAGCCAGGAAGCATCTGCCATCTACTTCACTAGTGGGACCAGTGGTCTTCCCAAGATGGCAGAAC
ATTCCTACTCGAGCCTGGGCCTCAAGGCCAAGATGGATGCTGGTTGGACAGGCCTGCAAGCCTCTGATATAATGTGGACCATATCAGACA
CAGGTTGGATACTGAACATCTTGTGCTCACTTATGGAACCTTGGGCATTAGGAGCATGCACATTTGTTCATCTCTTGCCAAAGTTTGACC
CACTGGTTATTCTAAAGACACTCTCCAGTTATCCAATCAAGAGTATGATGGGTGCCCCCATTGTTTACCGGATGTTGCTACAGCAGGATC
TTTCCAGTTACAAGTTCCCCCATCTACAGAACTGCGTCACTGTAGGGGAGTCCCTTCTTCCAGAAACTCTGGAGAACTGGAGGGCCCAGA
CAGGACTGGACATCCGAGAATCCTATGGCCAGACAGAAACGGGATTAACTTGCATGGTTTCCAAGACAATGAAAATCAAACCAGGATACA
TGGGAACGGCTGCTTCCTGTTATGATGTACAGATCATAGATGATAAGGGCAACGTCCTGCCCCCCGGCACAGAAGGAGACATTGGCATCA
GGGTCAAACCCATCAGGCCTATAGGCATCTTCTCTGGCTATGTGGACAATCCCGACAAGACAGCAGCCAACATTCGAGGAGACTTTTGGC
TCCTTGGAGACCGGGGAATCAAAGATGAAGATGGGTATTTCCAGTTTATGGGACGGGCAAATGATATCATTAACTCCAGCGGGTACCGGA
TTGGACCCTCGGAGGTAGAGAATGCACTGATGGAGCACCCTGCTGTGGTTGAGACGGCTGTGATCAGCAGCCCAGACCCCGTCCGAGGAG
AGGTGAAGGCCACAGTGCACCTGGCCTACCTGCGTGCCGTGGGCACCCCCCTCTGCCTCTACGCACTCTTCCTCTTCCTCTGCCAGCAAG
TGGCCTCCTTCTGCCGGGGCTACTGGCTGAGCCTGTGGGCGGACGACCCTGCAGTAGGTGGGCAGCAGACGCAGGCAGCCCTGCGTGGCG
GGATCTTCGGGCTCCTCGGCTGTCTCCAAGCCATTGGGCTGTTTGCCTCCATGGCTGCGGTGCTCCTAGGTGGGGCCCGGGCATCCAGGT
TGCTCTTCCAGAGGCTCCTGTGGGATGTGGTGCGATCTCCCATCAGCTTCTTTGAGCGGACACCCATTGGTCACCTGCTAAACCGCTTCT
CCAAGGAGACAGACACGGTTGACGTGGACATTCCAGACAAACTCCGGTCCCTGCTGATGTACGCCTTTGGACTCCTGGAGGTCAGCCTGG
TGGTGGCAGTGGCTACCCCACTGGCCACTGTGGCCATCCTGCCACTGTTTCTCCTCTACGCTGGGTTTCAGAGCCTGTATGTGGTTAGCT
CATGCCAGCTGAGACGCTTGGAGTCAGCCAGCTACTCGTCTGTCTGCTCCCACATGGCTGAGACGTTCCAGGGCAGCACAGTGGTCCGGG
CATTCCGAACCCAGGCCCCCTTTGTGGCTCAGAACAATGCTCGCGTAGATGAAAGCCAGAGGATCAGTTTCCCGCGACTGGTGGCTGACA
GGTGGCTTGCGGCCAATGTGGAGCTCCTGGGGAATGGCCTGGTGTTTGCAGCTGCCACGTGTGCTGTGCTGAGCAAAGCCCACCTCAGTG
CTGGCCTCGTGGGCTTCTCTGTCTCTGCTGCCCTCCAGGTGACCCAGACACTGCAGTGGGTTGTTCGCAACTGGACAGACCTAGAGAACA
GCATCGTGTCAGTGGAGCGGATGCAGGACTATGCCTGGACGCCCAAGGAGGCTCCCTGGAGGCTGCCCACATGTGCAGCTCAGCCCCCCT
GGCCTCAGGGCGGGCAGATCGAGTTCCGGGACTTTGGGCTAAGATACCGACCTGAGCTCCCGCTGGCTGTGCAGGGCGTGTCCTTCAAGA
TCCACGCAGGAGAGAAGGTGGGCATCGTTGGCAGGACCGGGGCAGGGAAGTCCTCCCTGGCCAGTGGGCTGCTGCGGCTCCAGGAGGCAG
CTGAGGGTGGGATCTGGATCGACGGGGTCCCCATTGCCCACGTGGGGCTGCACACACTGCGCTCCAGGATCAGCATCATCCCCCAGGACC
CCATCCTGTTCCCTGGCTCTCTGCGGATGAACCTCGACCTGCTGCAGGAGCACTCGGACGAGGCTATCTGGGCAGCCCTGGAGACGGTGC
AGCTCAAAGCCTTGGTGGCCAGCCTGCCCGGCCAGCTGCAGTACAAGTGTGCTGACCGAGGCGAGGACCTGAGCGTGGGCCAGAAACAGC
TCCTGTGTCTGGCACGTGCCCTTCTCCGGAAGACCCAGATCCTCATCCTGGACGAGGCTACTGCTGCCGTGGACCCTGGCACGGAGCTGC
AGATGCAGGCCATGCTCGGGAGCTGGTTTGCACAGTGCACTGTGCTGCTCATTGCCCACCGCCTGCGCTCCGTGATGGACTGTGCCCGGG
TTCTGGTCATGGACAAGGGGCAGGTGGCAGAGAGCGGCAGCCCGGCCCAGCTGCTGGCCCAGAAGGGCCTGTTTTACAGACTGGCCCAGG
AGTCAGGCCTGGTCTGAGCCAGGACCCTCAACCGTACCCCAGTTGGACCAGCCCGCACAGCCTGCAGTGCTGGAGATGGAAGTGACCCGT
GGTCATCGATAGCTCCACACGATATTGAGTCTAGACCTGTGTTTGCTCTCTGGGAGGAAAATGGCAGAGAAAGTGGCCAATTATCACAGA
GCATCAGAGCCGGAAGGACCTAGCAATACACAGGTCTGCCCGGGCAGGGCCCATCTCGCCCTGTCCACCCTGCAGCCAATGTCAACAGCG
ACTCTCAGCCCCGCTGTACTCTGGACTCACCTGGGGGCCTCAAGCACATGCCCAGGCTCCCGGCTAGACCCTTAAATCAGAATCTCTGAG
GCTGGGAACTGCCATGCTGTGTGTACTTTTTACAAATTAACACTTTTATTTTGGGATAATCCCAGACTCACATGCAGTTAAAGAAACAAT
AATATAGAGAGATTCGTGTACTTGGTACCCCATTTCACCCAATGGTAACATCTTGCAAAACTCTAGGATAAAGCATCACAGCCAGGGTGT
TGACATTGACACAACAATCTTGCTCGATTTCCCGTTTTACCTGTACTCCTGTGTGTGTGTGTGTTTATTTTGTCCCATGCAGTTTTATCA
CACATGTAGGCTCATGAATCCACACCAGGGTGAGGATACGGAATAGCCACCACCATTTTCCGACCACACCCATCACTCTCGCTCCTGCCC
CCAGTGACCATGCTCTGTTCTCCAGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTTTTTTTTTTTTTTTTTTGAGACAGAGTCT
CACTCTGTTGCTCAGGCTGGAGTGCAGTGGCTCAATCTCAGCTCACTGCAACCTCCACATCCTGGGTTCAAGCAATTCTCCTGCCTCAGC
CTCCCGTGCAGCTGAGATTACAGGCGTGCGCCACCATGCCTGGCTAACTTGTGTAATTTTTATTAGATACGAGGTTTCAGCATATTGGCC
AGGCTGGTCTTGAACTCCTGGCCTCATGTGATCCACCCTCCTCGGCCTCCCAAAGTGTTGGGATAACAGGCGTGAGCTACCGCACCTGGC
CGAGTTTGGTGTATAATTTTAAAGCTCCCCCATAGGATTCCAATGTGCGGCCAGGACTGAGAACTACAGCCCTCGCATCTCCTGCTGCTC

>1525_1525_3_ACSM2A-ABCC6_ACSM2A_chr16_20492243_ENST00000417235_ABCC6_chr16_16263710_ENST00000205557_length(amino acids)=1054AA_BP=0
LSYCALFQGCRSSGAAGWRGGWTKLSLERHPERTWQAGKRLPSPALWWVNGKGKELMWNFRELSENSQQAANVLSGACGLQRGDRVAVVL
PRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLRIKLLVSEKSCDGWLNFKKLLNEAST
THHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAKMDAGWTGLQASDIMWTISDTGWILNILCSLMEPWALGACTFVHLLPKFDP
LVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCVTVGESLLPETLENWRAQTGLDIRESYGQTETGLTCMVSKTMKIKPGYM
GTAASCYDVQIIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVDNPDKTAANIRGDFWLLGDRGIKDEDGYFQFMGRANDIINSSGYRI
GPSEVENALMEHPAVVETAVISSPDPVRGEVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGG
IFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLV
VAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADR
WLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPW
PQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDP
ILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQ

--------------------------------------------------------------
>1525_1525_4_ACSM2A-ABCC6_ACSM2A_chr16_20492243_ENST00000536134_ABCC6_chr16_16263710_ENST00000205557_length(transcript)=4464nt_BP=1534nt
GAGTTACTGTGCTCTCTTCCAAGGCTGTAGGAGTTCTGGAGCTGCTGGCTGGAGAGGAGGGTGGACGAAGCTCTCTCTAGAAAGACATCC
TGAGAGGACTTGGCAGGCCTGAATATGCATTGGCTGCGAAAAGTTCAGGGACTTTGCACCCTGTGGGGTACTCAGATGTCCAGCCGCACT
CTCTACATTAATAGTAGGCAACTGGTGTCCCTGCAGTGGGGCCACCAGGAAGTGCCGGCCAAGTTTAACTTTGCTAGTGATGTGTTGGAT
CACTGGGCTGACATGGAGAAGGCTGGCAAGCGACTCCCAAGCCCAGCCCTGTGGTGGGTGAATGGGAAGGGGAAGGAATTAATGTGGAAT
TTCAGAGAACTGAGTGAAAACAGCCAGCAGGCAGCCAACGTCCTCTCGGGAGCCTGTGGCCTGCAGCGTGGGGATCGTGTGGCAGTGGTG
CTGCCCCGAGTGCCTGAGTGGTGGCTGGTGATCCTGGGCTGCATTCGAGCAGGTCTCATCTTTATGCCTGGAACCATCCAGATGAAATCC
ACTGACATACTGTATAGGTTGCAGATGTCTAAGGCCAAGGCTATTGTTGCTGGGGATGAAGTCATCCAAGAAGTGGACACAGTGGCATCT
GAATGTCCTTCTCTGAGAATTAAGCTACTGGTGTCTGAGAAAAGCTGTGATGGGTGGCTGAACTTCAAGAAACTACTAAATGAGGCATCC
ACCACTCATCACTGTGTGGAGACTGGAAGCCAAGATGGATGCTGGTTGGACAGGCCTGCAAGCCTCTGATATAATGTGGACCATATCAGA
CACAGGTTGGATACTGAACATCTTGTGCTCACTTATGGAACCTTGGGCATTAGGAGCATGCACATTTGTTCATCTCTTGCCAAAGTTTGA
CCCACTGGTTATTCTAAAGACACTCTCCAGTTATCCAATCAAGAGTATGATGGGTGCCCCCATTGTTTACCGGATGTTGCTACAGCAGGA
TCTTTCCAGTTACAAGTTCCCCCATCTACAGAACTGCGTCACTGTAGGGGAGTCCCTTCTTCCAGAAACTCTGGAGAACTGGAGGGCCCA
GACAGGACTGGACATCCGAGAATCCTATGGCCAGACAGAAACGGGATTAACTTGCATGGTTTCCAAGACAATGAAAATCAAACCAGGATA
CATGGGAACGGCTGCTTCCTGTTATGATGTACAGATCATAGATGATAAGGGCAACGTCCTGCCCCCCGGCACAGAAGGAGACATTGGCAT
CAGGGTCAAACCCATCAGGCCTATAGGCATCTTCTCTGGCTATGTGGACAATCCCGACAAGACAGCAGCCAACATTCGAGGAGACTTTTG
GCTCCTTGGAGACCGGGGAATCAAAGATGAAGATGGGTATTTCCAGTTTATGGGACGGGCAAATGATATCATTAACTCCAGCGGGTACCG
GATTGGACCCTCGGAGGTAGAGAATGCACTGATGGAGCACCCTGCTGTGGTTGAGACGGCTGTGATCAGCAGCCCAGACCCCGTCCGAGG
AGAGGTGAAGGCCACAGTGCACCTGGCCTACCTGCGTGCCGTGGGCACCCCCCTCTGCCTCTACGCACTCTTCCTCTTCCTCTGCCAGCA
AGTGGCCTCCTTCTGCCGGGGCTACTGGCTGAGCCTGTGGGCGGACGACCCTGCAGTAGGTGGGCAGCAGACGCAGGCAGCCCTGCGTGG
CGGGATCTTCGGGCTCCTCGGCTGTCTCCAAGCCATTGGGCTGTTTGCCTCCATGGCTGCGGTGCTCCTAGGTGGGGCCCGGGCATCCAG
GTTGCTCTTCCAGAGGCTCCTGTGGGATGTGGTGCGATCTCCCATCAGCTTCTTTGAGCGGACACCCATTGGTCACCTGCTAAACCGCTT
CTCCAAGGAGACAGACACGGTTGACGTGGACATTCCAGACAAACTCCGGTCCCTGCTGATGTACGCCTTTGGACTCCTGGAGGTCAGCCT
GGTGGTGGCAGTGGCTACCCCACTGGCCACTGTGGCCATCCTGCCACTGTTTCTCCTCTACGCTGGGTTTCAGAGCCTGTATGTGGTTAG
CTCATGCCAGCTGAGACGCTTGGAGTCAGCCAGCTACTCGTCTGTCTGCTCCCACATGGCTGAGACGTTCCAGGGCAGCACAGTGGTCCG
GGCATTCCGAACCCAGGCCCCCTTTGTGGCTCAGAACAATGCTCGCGTAGATGAAAGCCAGAGGATCAGTTTCCCGCGACTGGTGGCTGA
CAGGTGGCTTGCGGCCAATGTGGAGCTCCTGGGGAATGGCCTGGTGTTTGCAGCTGCCACGTGTGCTGTGCTGAGCAAAGCCCACCTCAG
TGCTGGCCTCGTGGGCTTCTCTGTCTCTGCTGCCCTCCAGGTGACCCAGACACTGCAGTGGGTTGTTCGCAACTGGACAGACCTAGAGAA
CAGCATCGTGTCAGTGGAGCGGATGCAGGACTATGCCTGGACGCCCAAGGAGGCTCCCTGGAGGCTGCCCACATGTGCAGCTCAGCCCCC
CTGGCCTCAGGGCGGGCAGATCGAGTTCCGGGACTTTGGGCTAAGATACCGACCTGAGCTCCCGCTGGCTGTGCAGGGCGTGTCCTTCAA
GATCCACGCAGGAGAGAAGGTGGGCATCGTTGGCAGGACCGGGGCAGGGAAGTCCTCCCTGGCCAGTGGGCTGCTGCGGCTCCAGGAGGC
AGCTGAGGGTGGGATCTGGATCGACGGGGTCCCCATTGCCCACGTGGGGCTGCACACACTGCGCTCCAGGATCAGCATCATCCCCCAGGA
CCCCATCCTGTTCCCTGGCTCTCTGCGGATGAACCTCGACCTGCTGCAGGAGCACTCGGACGAGGCTATCTGGGCAGCCCTGGAGACGGT
GCAGCTCAAAGCCTTGGTGGCCAGCCTGCCCGGCCAGCTGCAGTACAAGTGTGCTGACCGAGGCGAGGACCTGAGCGTGGGCCAGAAACA
GCTCCTGTGTCTGGCACGTGCCCTTCTCCGGAAGACCCAGATCCTCATCCTGGACGAGGCTACTGCTGCCGTGGACCCTGGCACGGAGCT
GCAGATGCAGGCCATGCTCGGGAGCTGGTTTGCACAGTGCACTGTGCTGCTCATTGCCCACCGCCTGCGCTCCGTGATGGACTGTGCCCG
GGTTCTGGTCATGGACAAGGGGCAGGTGGCAGAGAGCGGCAGCCCGGCCCAGCTGCTGGCCCAGAAGGGCCTGTTTTACAGACTGGCCCA
GGAGTCAGGCCTGGTCTGAGCCAGGACCCTCAACCGTACCCCAGTTGGACCAGCCCGCACAGCCTGCAGTGCTGGAGATGGAAGTGACCC
GTGGTCATCGATAGCTCCACACGATATTGAGTCTAGACCTGTGTTTGCTCTCTGGGAGGAAAATGGCAGAGAAAGTGGCCAATTATCACA
GAGCATCAGAGCCGGAAGGACCTAGCAATACACAGGTCTGCCCGGGCAGGGCCCATCTCGCCCTGTCCACCCTGCAGCCAATGTCAACAG
CGACTCTCAGCCCCGCTGTACTCTGGACTCACCTGGGGGCCTCAAGCACATGCCCAGGCTCCCGGCTAGACCCTTAAATCAGAATCTCTG
AGGCTGGGAACTGCCATGCTGTGTGTACTTTTTACAAATTAACACTTTTATTTTGGGATAATCCCAGACTCACATGCAGTTAAAGAAACA
ATAATATAGAGAGATTCGTGTACTTGGTACCCCATTTCACCCAATGGTAACATCTTGCAAAACTCTAGGATAAAGCATCACAGCCAGGGT
GTTGACATTGACACAACAATCTTGCTCGATTTCCCGTTTTACCTGTACTCCTGTGTGTGTGTGTGTTTATTTTGTCCCATGCAGTTTTAT
CACACATGTAGGCTCATGAATCCACACCAGGGTGAGGATACGGAATAGCCACCACCATTTTCCGACCACACCCATCACTCTCGCTCCTGC
CCCCAGTGACCATGCTCTGTTCTCCAGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTTTTTTTTTTTTTTTTTTGAGACAGAGT
CTCACTCTGTTGCTCAGGCTGGAGTGCAGTGGCTCAATCTCAGCTCACTGCAACCTCCACATCCTGGGTTCAAGCAATTCTCCTGCCTCA
GCCTCCCGTGCAGCTGAGATTACAGGCGTGCGCCACCATGCCTGGCTAACTTGTGTAATTTTTATTAGATACGAGGTTTCAGCATATTGG
CCAGGCTGGTCTTGAACTCCTGGCCTCATGTGATCCACCCTCCTCGGCCTCCCAAAGTGTTGGGATAACAGGCGTGAGCTACCGCACCTG
GCCGAGTTTGGTGTATAATTTTAAAGCTCCCCCATAGGATTCCAATGTGCGGCCAGGACTGAGAACTACAGCCCTCGCATCTCCTGCTGC

>1525_1525_4_ACSM2A-ABCC6_ACSM2A_chr16_20492243_ENST00000536134_ABCC6_chr16_16263710_ENST00000205557_length(amino acids)=849AA_BP=275
MRHPPLITVWRLEAKMDAGWTGLQASDIMWTISDTGWILNILCSLMEPWALGACTFVHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRML
LQQDLSSYKFPHLQNCVTVGESLLPETLENWRAQTGLDIRESYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQIIDDKGNVLPPGTEG
DIGIRVKPIRPIGIFSGYVDNPDKTAANIRGDFWLLGDRGIKDEDGYFQFMGRANDIINSSGYRIGPSEVENALMEHPAVVETAVISSPD
PVRGEVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGA
RASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSL
YVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSK
AHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQG
VSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAA
LETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVM

--------------------------------------------------------------
>1525_1525_5_ACSM2A-ABCC6_ACSM2A_chr16_20492243_ENST00000573854_ABCC6_chr16_16263710_ENST00000205557_length(transcript)=4553nt_BP=1623nt
GAGTTACTGTGCTCTCTTCCAAGGCTGTAGGAGTTCTGGAGCTGCTGGCTGGAGAGGAGGGTGGACGAAGCTCTCTCTAGAAAGACATCC
TGAGAGGACTTGGCAGGCCTGAATATGCATTGGCTGCGAAAAGTTCAGGGACTTTGCACCCTGTGGGGTACTCAGATGTCCAGCCGCACT
CTCTACATTAATAGTAGGCAACTGGTGTCCCTGCAGTGGGGCCACCAGGAAGTGCCGGCCAAGTTTAACTTTGCTAGTGATGTGTTGGAT
CACTGGGCTGACATGGAGAAGGCTGGCAAGCGACTCCCAAGCCCAGCCCTGTGGTGGGTGAATGGGAAGGGGAAGGAATTAATGTGGAAT
TTCAGAGAACTGAGTGAAAACAGCCAGCAGGCAGCCAACGTCCTCTCGGGAGCCTGTGGCCTGCAGCGTGGGGATCGTGTGGCAGTGGTG
CTGCCCCGAGTGCCTGAGTGGTGGCTGGTGATCCTGGGCTGCATTCGAGCAGGTCTCATCTTTATGCCTGGAACCATCCAGATGAAATCC
ACTGACATACTGTATAGGTTGCAGATGTCTAAGGCCAAGGCTATTGTTGCTGGGGATGAAGTCATCCAAGAAGTGGACACAGTGGCATCT
GAATGTCCTTCTCTGAGAATTAAGCTACTGGTGTCTGAGAAAAGCTGTGATGGGTGGCTGAACTTCAAGAAACTACTAAATGAGGCATCC
ACCACTCATCACTGTGTGGAGACTGGAAGCCAGGAAGCATCTGCCATCTACTTCACTAGTGGGACCAGTGGTCTTCCCAAGATGGCAGAA
CATTCCTACTCGAGCCTGGGCCTCAAGGCCAAGATGGATGCTGGTTGGACAGGCCTGCAAGCCTCTGATATAATGTGGACCATATCAGAC
ACAGGTTGGATACTGAACATCTTGTGCTCACTTATGGAACCTTGGGCATTAGGAGCATGCACATTTGTTCATCTCTTGCCAAAGTTTGAC
CCACTGGTTATTCTAAAGACACTCTCCAGTTATCCAATCAAGAGTATGATGGGTGCCCCCATTGTTTACCGGATGTTGCTACAGCAGGAT
CTTTCCAGTTACAAGTTCCCCCATCTACAGAACTGCGTCACTGTAGGGGAGTCCCTTCTTCCAGAAACTCTGGAGAACTGGAGGGCCCAG
ACAGGACTGGACATCCGAGAATCCTATGGCCAGACAGAAACGGGATTAACTTGCATGGTTTCCAAGACAATGAAAATCAAACCAGGATAC
ATGGGAACGGCTGCTTCCTGTTATGATGTACAGATCATAGATGATAAGGGCAACGTCCTGCCCCCCGGCACAGAAGGAGACATTGGCATC
AGGGTCAAACCCATCAGGCCTATAGGCATCTTCTCTGGCTATGTGGACAATCCCGACAAGACAGCAGCCAACATTCGAGGAGACTTTTGG
CTCCTTGGAGACCGGGGAATCAAAGATGAAGATGGGTATTTCCAGTTTATGGGACGGGCAAATGATATCATTAACTCCAGCGGGTACCGG
ATTGGACCCTCGGAGGTAGAGAATGCACTGATGGAGCACCCTGCTGTGGTTGAGACGGCTGTGATCAGCAGCCCAGACCCCGTCCGAGGA
GAGGTGAAGGCCACAGTGCACCTGGCCTACCTGCGTGCCGTGGGCACCCCCCTCTGCCTCTACGCACTCTTCCTCTTCCTCTGCCAGCAA
GTGGCCTCCTTCTGCCGGGGCTACTGGCTGAGCCTGTGGGCGGACGACCCTGCAGTAGGTGGGCAGCAGACGCAGGCAGCCCTGCGTGGC
GGGATCTTCGGGCTCCTCGGCTGTCTCCAAGCCATTGGGCTGTTTGCCTCCATGGCTGCGGTGCTCCTAGGTGGGGCCCGGGCATCCAGG
TTGCTCTTCCAGAGGCTCCTGTGGGATGTGGTGCGATCTCCCATCAGCTTCTTTGAGCGGACACCCATTGGTCACCTGCTAAACCGCTTC
TCCAAGGAGACAGACACGGTTGACGTGGACATTCCAGACAAACTCCGGTCCCTGCTGATGTACGCCTTTGGACTCCTGGAGGTCAGCCTG
GTGGTGGCAGTGGCTACCCCACTGGCCACTGTGGCCATCCTGCCACTGTTTCTCCTCTACGCTGGGTTTCAGAGCCTGTATGTGGTTAGC
TCATGCCAGCTGAGACGCTTGGAGTCAGCCAGCTACTCGTCTGTCTGCTCCCACATGGCTGAGACGTTCCAGGGCAGCACAGTGGTCCGG
GCATTCCGAACCCAGGCCCCCTTTGTGGCTCAGAACAATGCTCGCGTAGATGAAAGCCAGAGGATCAGTTTCCCGCGACTGGTGGCTGAC
AGGTGGCTTGCGGCCAATGTGGAGCTCCTGGGGAATGGCCTGGTGTTTGCAGCTGCCACGTGTGCTGTGCTGAGCAAAGCCCACCTCAGT
GCTGGCCTCGTGGGCTTCTCTGTCTCTGCTGCCCTCCAGGTGACCCAGACACTGCAGTGGGTTGTTCGCAACTGGACAGACCTAGAGAAC
AGCATCGTGTCAGTGGAGCGGATGCAGGACTATGCCTGGACGCCCAAGGAGGCTCCCTGGAGGCTGCCCACATGTGCAGCTCAGCCCCCC
TGGCCTCAGGGCGGGCAGATCGAGTTCCGGGACTTTGGGCTAAGATACCGACCTGAGCTCCCGCTGGCTGTGCAGGGCGTGTCCTTCAAG
ATCCACGCAGGAGAGAAGGTGGGCATCGTTGGCAGGACCGGGGCAGGGAAGTCCTCCCTGGCCAGTGGGCTGCTGCGGCTCCAGGAGGCA
GCTGAGGGTGGGATCTGGATCGACGGGGTCCCCATTGCCCACGTGGGGCTGCACACACTGCGCTCCAGGATCAGCATCATCCCCCAGGAC
CCCATCCTGTTCCCTGGCTCTCTGCGGATGAACCTCGACCTGCTGCAGGAGCACTCGGACGAGGCTATCTGGGCAGCCCTGGAGACGGTG
CAGCTCAAAGCCTTGGTGGCCAGCCTGCCCGGCCAGCTGCAGTACAAGTGTGCTGACCGAGGCGAGGACCTGAGCGTGGGCCAGAAACAG
CTCCTGTGTCTGGCACGTGCCCTTCTCCGGAAGACCCAGATCCTCATCCTGGACGAGGCTACTGCTGCCGTGGACCCTGGCACGGAGCTG
CAGATGCAGGCCATGCTCGGGAGCTGGTTTGCACAGTGCACTGTGCTGCTCATTGCCCACCGCCTGCGCTCCGTGATGGACTGTGCCCGG
GTTCTGGTCATGGACAAGGGGCAGGTGGCAGAGAGCGGCAGCCCGGCCCAGCTGCTGGCCCAGAAGGGCCTGTTTTACAGACTGGCCCAG
GAGTCAGGCCTGGTCTGAGCCAGGACCCTCAACCGTACCCCAGTTGGACCAGCCCGCACAGCCTGCAGTGCTGGAGATGGAAGTGACCCG
TGGTCATCGATAGCTCCACACGATATTGAGTCTAGACCTGTGTTTGCTCTCTGGGAGGAAAATGGCAGAGAAAGTGGCCAATTATCACAG
AGCATCAGAGCCGGAAGGACCTAGCAATACACAGGTCTGCCCGGGCAGGGCCCATCTCGCCCTGTCCACCCTGCAGCCAATGTCAACAGC
GACTCTCAGCCCCGCTGTACTCTGGACTCACCTGGGGGCCTCAAGCACATGCCCAGGCTCCCGGCTAGACCCTTAAATCAGAATCTCTGA
GGCTGGGAACTGCCATGCTGTGTGTACTTTTTACAAATTAACACTTTTATTTTGGGATAATCCCAGACTCACATGCAGTTAAAGAAACAA
TAATATAGAGAGATTCGTGTACTTGGTACCCCATTTCACCCAATGGTAACATCTTGCAAAACTCTAGGATAAAGCATCACAGCCAGGGTG
TTGACATTGACACAACAATCTTGCTCGATTTCCCGTTTTACCTGTACTCCTGTGTGTGTGTGTGTTTATTTTGTCCCATGCAGTTTTATC
ACACATGTAGGCTCATGAATCCACACCAGGGTGAGGATACGGAATAGCCACCACCATTTTCCGACCACACCCATCACTCTCGCTCCTGCC
CCCAGTGACCATGCTCTGTTCTCCAGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTTTTTTTTTTTTTTTTTTGAGACAGAGTC
TCACTCTGTTGCTCAGGCTGGAGTGCAGTGGCTCAATCTCAGCTCACTGCAACCTCCACATCCTGGGTTCAAGCAATTCTCCTGCCTCAG
CCTCCCGTGCAGCTGAGATTACAGGCGTGCGCCACCATGCCTGGCTAACTTGTGTAATTTTTATTAGATACGAGGTTTCAGCATATTGGC
CAGGCTGGTCTTGAACTCCTGGCCTCATGTGATCCACCCTCCTCGGCCTCCCAAAGTGTTGGGATAACAGGCGTGAGCTACCGCACCTGG
CCGAGTTTGGTGTATAATTTTAAAGCTCCCCCATAGGATTCCAATGTGCGGCCAGGACTGAGAACTACAGCCCTCGCATCTCCTGCTGCT

>1525_1525_5_ACSM2A-ABCC6_ACSM2A_chr16_20492243_ENST00000573854_ABCC6_chr16_16263710_ENST00000205557_length(amino acids)=1082AA_BP=2
MAGLNMHWLRKVQGLCTLWGTQMSSRTLYINSRQLVSLQWGHQEVPAKFNFASDVLDHWADMEKAGKRLPSPALWWVNGKGKELMWNFRE
LSENSQQAANVLSGACGLQRGDRVAVVLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECP
SLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAKMDAGWTGLQASDIMWTISDTGW
ILNILCSLMEPWALGACTFVHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCVTVGESLLPETLENWRAQTGL
DIRESYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQIIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVDNPDKTAANIRGDFWLLG
DRGIKDEDGYFQFMGRANDIINSSGYRIGPSEVENALMEHPAVVETAVISSPDPVRGEVKATVHLAYLRAVGTPLCLYALFLFLCQQVAS
FCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKE
TDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFR
TQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIV
SVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEG
GIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLC
LARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESG

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>1525_1525_6_ACSM2A-ABCC6_ACSM2A_chr16_20492243_ENST00000575690_ABCC6_chr16_16263710_ENST00000205557_length(transcript)=4909nt_BP=1979nt
GTAGGAGTTCTGGAGCTGCTGGCTGGAGAGGAGGGTGGACGAAGCTCTCTCTAGAAAGACATCCTGAGAGGACTTGGCAGAAAAAAAGGA
GACAGAAATGTCAGACACTGTGATGGTTAATACTGAGTGTCAATTGATTGAATTGAAGGATACAAAGTGTTGATCCTGGATGTGTCTGTG
AGGGTGTTGTCAAAAGAGATTAACATTTGAGTCGGTGGGCTGGGAGAGGCAGACCCACCCTTAATCTGGGTAGGAACCACCTAATCCAGC
ATGACTAGAATATAAGCAGGCAGAAAAATATGAAAAGAGAGACTGGCCTAGCTTCCCAGCCTAGATCTTTCTTCCGTACTGGATGCTTCC
TGCACTTGAACATCAGACTCCAGGTTCTTCAGTTTTGGAACTCAAACTGGCTCTCCTTGCACCTCAGCCTGCAGATGGCCTATTGTGGGA
CCTTGTGATCATGCCTGAATATGCATTGGCTGCGAAAAGTTCAGGGACTTTGCACCCTGTGGGGTACTCAGATGTCCAGCCGCACTCTCT
ACATTAATAGTAGGCAACTGGTGTCCCTGCAGTGGGGCCACCAGGAAGTGCCGGCCAAGTTTAACTTTGCTAGTGATGTGTTGGATCACT
GGGCTGACATGGAGAAGGCTGGCAAGCGACTCCCAAGCCCAGCCCTGTGGTGGGTGAATGGGAAGGGGAAGGAATTAATGTGGAATTTCA
GAGAACTGAGTGAAAACAGCCAGCAGGCAGCCAACGTCCTCTCGGGAGCCTGTGGCCTGCAGCGTGGGGATCGTGTGGCAGTGGTGCTGC
CCCGAGTGCCTGAGTGGTGGCTGGTGATCCTGGGCTGCATTCGAGCAGGTCTCATCTTTATGCCTGGAACCATCCAGATGAAATCCACTG
ACATACTGTATAGGTTGCAGATGTCTAAGGCCAAGGCTATTGTTGCTGGGGATGAAGTCATCCAAGAAGTGGACACAGTGGCATCTGAAT
GTCCTTCTCTGAGAATTAAGCTACTGGTGTCTGAGAAAAGCTGTGATGGGTGGCTGAACTTCAAGAAACTACTAAATGAGGCATCCACCA
CTCATCACTGTGTGGAGACTGGAAGCCAGGAAGCATCTGCCATCTACTTCACTAGTGGGACCAGTGGTCTTCCCAAGATGGCAGAACATT
CCTACTCGAGCCTGGGCCTCAAGGCCAAGATGGATGCTGGTTGGACAGGCCTGCAAGCCTCTGATATAATGTGGACCATATCAGACACAG
GTTGGATACTGAACATCTTGTGCTCACTTATGGAACCTTGGGCATTAGGAGCATGCACATTTGTTCATCTCTTGCCAAAGTTTGACCCAC
TGGTTATTCTAAAGACACTCTCCAGTTATCCAATCAAGAGTATGATGGGTGCCCCCATTGTTTACCGGATGTTGCTACAGCAGGATCTTT
CCAGTTACAAGTTCCCCCATCTACAGAACTGCGTCACTGTAGGGGAGTCCCTTCTTCCAGAAACTCTGGAGAACTGGAGGGCCCAGACAG
GACTGGACATCCGAGAATCCTATGGCCAGACAGAAACGGGATTAACTTGCATGGTTTCCAAGACAATGAAAATCAAACCAGGATACATGG
GAACGGCTGCTTCCTGTTATGATGTACAGATCATAGATGATAAGGGCAACGTCCTGCCCCCCGGCACAGAAGGAGACATTGGCATCAGGG
TCAAACCCATCAGGCCTATAGGCATCTTCTCTGGCTATGTGGACAATCCCGACAAGACAGCAGCCAACATTCGAGGAGACTTTTGGCTCC
TTGGAGACCGGGGAATCAAAGATGAAGATGGGTATTTCCAGTTTATGGGACGGGCAAATGATATCATTAACTCCAGCGGGTACCGGATTG
GACCCTCGGAGGTAGAGAATGCACTGATGGAGCACCCTGCTGTGGTTGAGACGGCTGTGATCAGCAGCCCAGACCCCGTCCGAGGAGAGG
TGAAGGCCACAGTGCACCTGGCCTACCTGCGTGCCGTGGGCACCCCCCTCTGCCTCTACGCACTCTTCCTCTTCCTCTGCCAGCAAGTGG
CCTCCTTCTGCCGGGGCTACTGGCTGAGCCTGTGGGCGGACGACCCTGCAGTAGGTGGGCAGCAGACGCAGGCAGCCCTGCGTGGCGGGA
TCTTCGGGCTCCTCGGCTGTCTCCAAGCCATTGGGCTGTTTGCCTCCATGGCTGCGGTGCTCCTAGGTGGGGCCCGGGCATCCAGGTTGC
TCTTCCAGAGGCTCCTGTGGGATGTGGTGCGATCTCCCATCAGCTTCTTTGAGCGGACACCCATTGGTCACCTGCTAAACCGCTTCTCCA
AGGAGACAGACACGGTTGACGTGGACATTCCAGACAAACTCCGGTCCCTGCTGATGTACGCCTTTGGACTCCTGGAGGTCAGCCTGGTGG
TGGCAGTGGCTACCCCACTGGCCACTGTGGCCATCCTGCCACTGTTTCTCCTCTACGCTGGGTTTCAGAGCCTGTATGTGGTTAGCTCAT
GCCAGCTGAGACGCTTGGAGTCAGCCAGCTACTCGTCTGTCTGCTCCCACATGGCTGAGACGTTCCAGGGCAGCACAGTGGTCCGGGCAT
TCCGAACCCAGGCCCCCTTTGTGGCTCAGAACAATGCTCGCGTAGATGAAAGCCAGAGGATCAGTTTCCCGCGACTGGTGGCTGACAGGT
GGCTTGCGGCCAATGTGGAGCTCCTGGGGAATGGCCTGGTGTTTGCAGCTGCCACGTGTGCTGTGCTGAGCAAAGCCCACCTCAGTGCTG
GCCTCGTGGGCTTCTCTGTCTCTGCTGCCCTCCAGGTGACCCAGACACTGCAGTGGGTTGTTCGCAACTGGACAGACCTAGAGAACAGCA
TCGTGTCAGTGGAGCGGATGCAGGACTATGCCTGGACGCCCAAGGAGGCTCCCTGGAGGCTGCCCACATGTGCAGCTCAGCCCCCCTGGC
CTCAGGGCGGGCAGATCGAGTTCCGGGACTTTGGGCTAAGATACCGACCTGAGCTCCCGCTGGCTGTGCAGGGCGTGTCCTTCAAGATCC
ACGCAGGAGAGAAGGTGGGCATCGTTGGCAGGACCGGGGCAGGGAAGTCCTCCCTGGCCAGTGGGCTGCTGCGGCTCCAGGAGGCAGCTG
AGGGTGGGATCTGGATCGACGGGGTCCCCATTGCCCACGTGGGGCTGCACACACTGCGCTCCAGGATCAGCATCATCCCCCAGGACCCCA
TCCTGTTCCCTGGCTCTCTGCGGATGAACCTCGACCTGCTGCAGGAGCACTCGGACGAGGCTATCTGGGCAGCCCTGGAGACGGTGCAGC
TCAAAGCCTTGGTGGCCAGCCTGCCCGGCCAGCTGCAGTACAAGTGTGCTGACCGAGGCGAGGACCTGAGCGTGGGCCAGAAACAGCTCC
TGTGTCTGGCACGTGCCCTTCTCCGGAAGACCCAGATCCTCATCCTGGACGAGGCTACTGCTGCCGTGGACCCTGGCACGGAGCTGCAGA
TGCAGGCCATGCTCGGGAGCTGGTTTGCACAGTGCACTGTGCTGCTCATTGCCCACCGCCTGCGCTCCGTGATGGACTGTGCCCGGGTTC
TGGTCATGGACAAGGGGCAGGTGGCAGAGAGCGGCAGCCCGGCCCAGCTGCTGGCCCAGAAGGGCCTGTTTTACAGACTGGCCCAGGAGT
CAGGCCTGGTCTGAGCCAGGACCCTCAACCGTACCCCAGTTGGACCAGCCCGCACAGCCTGCAGTGCTGGAGATGGAAGTGACCCGTGGT
CATCGATAGCTCCACACGATATTGAGTCTAGACCTGTGTTTGCTCTCTGGGAGGAAAATGGCAGAGAAAGTGGCCAATTATCACAGAGCA
TCAGAGCCGGAAGGACCTAGCAATACACAGGTCTGCCCGGGCAGGGCCCATCTCGCCCTGTCCACCCTGCAGCCAATGTCAACAGCGACT
CTCAGCCCCGCTGTACTCTGGACTCACCTGGGGGCCTCAAGCACATGCCCAGGCTCCCGGCTAGACCCTTAAATCAGAATCTCTGAGGCT
GGGAACTGCCATGCTGTGTGTACTTTTTACAAATTAACACTTTTATTTTGGGATAATCCCAGACTCACATGCAGTTAAAGAAACAATAAT
ATAGAGAGATTCGTGTACTTGGTACCCCATTTCACCCAATGGTAACATCTTGCAAAACTCTAGGATAAAGCATCACAGCCAGGGTGTTGA
CATTGACACAACAATCTTGCTCGATTTCCCGTTTTACCTGTACTCCTGTGTGTGTGTGTGTTTATTTTGTCCCATGCAGTTTTATCACAC
ATGTAGGCTCATGAATCCACACCAGGGTGAGGATACGGAATAGCCACCACCATTTTCCGACCACACCCATCACTCTCGCTCCTGCCCCCA
GTGACCATGCTCTGTTCTCCAGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCAC
TCTGTTGCTCAGGCTGGAGTGCAGTGGCTCAATCTCAGCTCACTGCAACCTCCACATCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTC
CCGTGCAGCTGAGATTACAGGCGTGCGCCACCATGCCTGGCTAACTTGTGTAATTTTTATTAGATACGAGGTTTCAGCATATTGGCCAGG
CTGGTCTTGAACTCCTGGCCTCATGTGATCCACCCTCCTCGGCCTCCCAAAGTGTTGGGATAACAGGCGTGAGCTACCGCACCTGGCCGA
GTTTGGTGTATAATTTTAAAGCTCCCCCATAGGATTCCAATGTGCGGCCAGGACTGAGAACTACAGCCCTCGCATCTCCTGCTGCTCCTC

>1525_1525_6_ACSM2A-ABCC6_ACSM2A_chr16_20492243_ENST00000575690_ABCC6_chr16_16263710_ENST00000205557_length(amino acids)=1079AA_BP=1
MNMHWLRKVQGLCTLWGTQMSSRTLYINSRQLVSLQWGHQEVPAKFNFASDVLDHWADMEKAGKRLPSPALWWVNGKGKELMWNFRELSE
NSQQAANVLSGACGLQRGDRVAVVLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLR
IKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAKMDAGWTGLQASDIMWTISDTGWILN
ILCSLMEPWALGACTFVHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCVTVGESLLPETLENWRAQTGLDIR
ESYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQIIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVDNPDKTAANIRGDFWLLGDRG
IKDEDGYFQFMGRANDIINSSGYRIGPSEVENALMEHPAVVETAVISSPDPVRGEVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCR
GYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDT
VDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQA
PFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVE
RMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIW
IDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLAR

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Fusion Gene PPI Analysis for ACSM2A-ABCC6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ACSM2A-ABCC6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ACSM2A-ABCC6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene		C0033847	Pseudoxanthoma Elasticum	26	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C1867450	Pseudoxanthoma Elasticum, Incomplete	11	CTD_human;GENOMICS_ENGLAND
Tgene		C0376359	Gronblad-Strandberg Syndrome	8	CTD_human
Tgene		C1859727	Arterial calcification of infancy	2	CTD_human;ORPHANET
Tgene		C3276161	ARTERIAL CALCIFICATION, GENERALIZED, OF INFANCY, 2	2	GENOMICS_ENGLAND;UNIPROT
Tgene		C0009402	Colorectal Carcinoma	1	CTD_human
Tgene		C0009404	Colorectal Neoplasms	1	CTD_human
Tgene		C0235874	Disease Exacerbation	1	CTD_human
Tgene		C0264955	Idiopathic arterial calcification of infancy	1	ORPHANET

Fusion Gene Studies in Kim Lab

Fusion gene:ACSM2A-ABCC6 (FusionGDB2 ID:HG123876TG368)

Fusion Gene Summary for ACSM2A-ABCC6

Fusion Gene ORF analysis for ACSM2A-ABCC6

Fusion Genomic Features for ACSM2A-ABCC6

Fusion Protein Features for ACSM2A-ABCC6

Fusion Gene Sequence for ACSM2A-ABCC6

Fusion Gene PPI Analysis for ACSM2A-ABCC6

Related Drugs for ACSM2A-ABCC6

Related Diseases for ACSM2A-ABCC6

Fusion Gene Studies
in Kim Lab