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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CNN1-CNN2 (FusionGDB2 ID:HG1264TG1265)

Fusion Gene Summary for CNN1-CNN2

check button Fusion gene summary
Fusion gene informationFusion gene name: CNN1-CNN2
Fusion gene ID: hg1264tg1265
HgeneTgene
Gene symbol

CNN1

CNN2

Gene ID

1264

1265

Gene namecalponin 1calponin 2
SynonymsHEL-S-14|SMCC|Sm-Calp-
Cytomap('CNN1')('CNN2')

19p13.2

19p13.3

Type of geneprotein-codingprotein-coding
Descriptioncalponin-1basic calponincalponin 1, basic, smooth musclecalponin H1, smooth musclecalponins, basicepididymis secretory protein Li 14calponin-2calponin H2, smooth muscleneutral calponin
Modification date2020031320200313
UniProtAcc

P51911

Q99439

Ensembl transtripts involved in fusion geneENST00000252456, ENST00000535659, 
ENST00000544952, ENST00000592923, 
ENST00000588468, 
Fusion gene scores* DoF score7 X 5 X 4=14012 X 12 X 8=1152
# samples 714
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1152*10)=-3.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CNN1 [Title/Abstract] AND CNN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCNN1(11658722)-CNN2(1036414), # samples:2
Anticipated loss of major functional domain due to fusion event.CNN1-CNN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CNN1-CNN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CNN1-CNN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CNN1-CNN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCNN2

GO:0032970

regulation of actin filament-based process

16236705

TgeneCNN2

GO:0071260

cellular response to mechanical stimulus

16236705


check buttonFusion gene breakpoints across CNN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CNN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer181NCNN1chr19

11658722

+CNN2chr19

1036414

+
ChimerDB4Non-Cancer265NCNN1chr19

11658722

+CNN2chr19

1036414

+


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Fusion Gene ORF analysis for CNN1-CNN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000252456ENST00000348419CNN1chr19

11658722

+CNN2chr19

1036414

+
5CDS-3UTRENST00000252456ENST00000562958CNN1chr19

11658722

+CNN2chr19

1036414

+
5CDS-3UTRENST00000252456ENST00000565096CNN1chr19

11658722

+CNN2chr19

1036414

+
5CDS-3UTRENST00000252456ENST00000606983CNN1chr19

11658722

+CNN2chr19

1036414

+
5CDS-3UTRENST00000535659ENST00000348419CNN1chr19

11658722

+CNN2chr19

1036414

+
5CDS-3UTRENST00000535659ENST00000562958CNN1chr19

11658722

+CNN2chr19

1036414

+
5CDS-3UTRENST00000535659ENST00000565096CNN1chr19

11658722

+CNN2chr19

1036414

+
5CDS-3UTRENST00000535659ENST00000606983CNN1chr19

11658722

+CNN2chr19

1036414

+
5CDS-3UTRENST00000544952ENST00000348419CNN1chr19

11658722

+CNN2chr19

1036414

+
5CDS-3UTRENST00000544952ENST00000562958CNN1chr19

11658722

+CNN2chr19

1036414

+
5CDS-3UTRENST00000544952ENST00000565096CNN1chr19

11658722

+CNN2chr19

1036414

+
5CDS-3UTRENST00000544952ENST00000606983CNN1chr19

11658722

+CNN2chr19

1036414

+
5CDS-3UTRENST00000592923ENST00000348419CNN1chr19

11658722

+CNN2chr19

1036414

+
5CDS-3UTRENST00000592923ENST00000562958CNN1chr19

11658722

+CNN2chr19

1036414

+
5CDS-3UTRENST00000592923ENST00000565096CNN1chr19

11658722

+CNN2chr19

1036414

+
5CDS-3UTRENST00000592923ENST00000606983CNN1chr19

11658722

+CNN2chr19

1036414

+
In-frameENST00000252456ENST00000263097CNN1chr19

11658722

+CNN2chr19

1036414

+
In-frameENST00000535659ENST00000263097CNN1chr19

11658722

+CNN2chr19

1036414

+
In-frameENST00000544952ENST00000263097CNN1chr19

11658722

+CNN2chr19

1036414

+
In-frameENST00000592923ENST00000263097CNN1chr19

11658722

+CNN2chr19

1036414

+
intron-3CDSENST00000588468ENST00000263097CNN1chr19

11658722

+CNN2chr19

1036414

+
intron-3UTRENST00000588468ENST00000348419CNN1chr19

11658722

+CNN2chr19

1036414

+
intron-3UTRENST00000588468ENST00000562958CNN1chr19

11658722

+CNN2chr19

1036414

+
intron-3UTRENST00000588468ENST00000565096CNN1chr19

11658722

+CNN2chr19

1036414

+
intron-3UTRENST00000588468ENST00000606983CNN1chr19

11658722

+CNN2chr19

1036414

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000252456CNN1chr1911658722+ENST00000263097CNN2chr191036414+2304712761134352
ENST00000592923CNN1chr1911658722+ENST00000263097CNN2chr191036414+25209284781350290
ENST00000535659CNN1chr1911658722+ENST00000263097CNN2chr191036414+25219294701351293
ENST00000544952CNN1chr1911658722+ENST00000263097CNN2chr191036414+20824901912303

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000252456ENST00000263097CNN1chr1911658722+CNN2chr191036414+0.0029413910.99705863
ENST00000592923ENST00000263097CNN1chr1911658722+CNN2chr191036414+0.0129252780.98707473
ENST00000535659ENST00000263097CNN1chr1911658722+CNN2chr191036414+0.0131530290.986847
ENST00000544952ENST00000263097CNN1chr1911658722+CNN2chr191036414+0.0059623070.99403775

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Fusion Genomic Features for CNN1-CNN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CNN1chr1911658722+CNN2chr191036414+0.99055840.009441631
CNN1chr1911658722+CNN2chr191036414+0.99055840.009441631

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CNN1-CNN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:11658722/chr19:1036414)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CNN1

P51911

CNN2

Q99439

FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). {ECO:0000250}.FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCNN1chr19:11658722chr19:1036414ENST00000252456+5728_131167298.0DomainCalponin-homology (CH)
TgeneCNN2chr19:11658722chr19:1036414ENST0000026309747166_191169310.0RepeatNote=Calponin-like 1
TgeneCNN2chr19:11658722chr19:1036414ENST0000026309747206_231169310.0RepeatNote=Calponin-like 2
TgeneCNN2chr19:11658722chr19:1036414ENST0000026309747245_269169310.0RepeatNote=Calponin-like 3
TgeneCNN2chr19:11658722chr19:1036414ENST0000034841936166_191130271.0RepeatNote=Calponin-like 1
TgeneCNN2chr19:11658722chr19:1036414ENST0000034841936206_231130271.0RepeatNote=Calponin-like 2
TgeneCNN2chr19:11658722chr19:1036414ENST0000034841936245_269130271.0RepeatNote=Calponin-like 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCNN1chr19:11658722chr19:1036414ENST00000252456+57164_189167298.0RepeatNote=Calponin-like 1
HgeneCNN1chr19:11658722chr19:1036414ENST00000252456+57204_229167298.0RepeatNote=Calponin-like 2
HgeneCNN1chr19:11658722chr19:1036414ENST00000252456+57243_268167298.0RepeatNote=Calponin-like 3
TgeneCNN2chr19:11658722chr19:1036414ENST000002630974728_132169310.0DomainCalponin-homology (CH)
TgeneCNN2chr19:11658722chr19:1036414ENST000003484193628_132130271.0DomainCalponin-homology (CH)


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Fusion Gene Sequence for CNN1-CNN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>17666_17666_1_CNN1-CNN2_CNN1_chr19_11658722_ENST00000252456_CNN2_chr19_1036414_ENST00000263097_length(transcript)=2304nt_BP=712nt
GGGAGGGGAAGGCAGCTGAGGTTGTGGGGGGAGGTGCCCCGCCCCTTGGCAGGCCCCTACAGCCAATGGAACGGCCCTGGAAGAGACCCG
GGTCGCCTCCGGAGCTTCAAAAACATGTGAGGAGGGAAGAGTGTGCAGACGGAACTTCAGCCGCTGCCTCTGTTCTCAGCGTCAGTGCCG
CCACTGCCCCCGCCAGAGCCCACCGGCCAGCATGTCCTCTGCTCACTTCAACCGAGGCCCTGCCTACGGGCTGTCAGCCGAGGTTAAGAA
CAAGCTGGCCCAGAAGTATGACCACCAGCGGGAGCAGGAGCTGAGAGAGTGGATCGAGGGGGTGACAGGCCGTCGCATCGGCAACAACTT
CATGGACGGCCTCAAAGATGGCATCATTCTTTGCGAATTCATCAATAAGCTGCAGCCAGGCTCCGTGAAGAAGATCAATGAGTCAACCCA
AAATTGGCACCAGCTGGAGAACATCGGCAACTTCATCAAGGCCATCACCAAGTATGGGGTGAAGCCCCACGACATTTTTGAGGCCAACGA
CCTGTTTGAGAACACCAACCATACACAGGTGCAGTCCACCCTCCTGGCTTTGGCCAGCATGGCGAAGACGAAAGGAAACAAGGTGAACGT
GGGAGTGAAGTACGCAGAGAAGCAGGAGCGGAAATTCGAGCCGGGGAAGCTAAGAGAAGGGCGGAACATCATTGGGCTGCAGATGGGCAC
CAACAAATGCGCCAGCCAGTCGGGCATGACTGCCTACGGCACGAGAAGGCATCTCTATGACCCCAAGAACCATATCCTGCCCCCCATGGA
CCACTCGACCATCAGCCTCCAGATGGGCACGAACAAGTGTGCCAGCCAGGTGGGCATGACGGCTCCCGGGACCCGGCGGCACATCTATGA
TACCAAGCTGGGAACCGACAAGTGTGACAACTCCTCCATGTCCCTGCAGATGGGCTACACGCAGGGCGCCAACCAGAGCGGCCAGGTCTT
CGGCCTGGGCCGGCAGATATATGACCCCAAGTACTGCCCGCAAGGCACAGTGGCCGATGGGGCTCCCTCGGGCACCGGCGACTGCCCGGA
CCCGGGGGAGGTCCCTGAATATCCCCCTTACTACCAGGAGGAGGCCGGCTACTGAGGCTCCCAGCACGCTCTCTCCCCACATCGTCTGCC
CATCTGGGTTTTTGGGTTTTTCTGTGTTTTCATCTTTTTTTTTTTTTTCTTAACCCGTTCAGTGCTGCCAGTCAACCAAGGGTCTGTGAG
TGTCAGCGTGGGATCAGGCAGCAGAGCTTTTTTCCCCTTTGCCTTGATCCTTCGCAAGGCTGAGCCACTGGGCTGTGGGGGAAGGGGTCA
AGGCCATATCCCAATACGTGTAGGGCGAGGGTCCCTGCTGGCACATTCAGGCTGTGCTGGGAAGAAGAGACCTGGGCTTGGAAGGAACCG
GTCCCCGACGGTTTCTGCTTGCCTCGCCTCTTCCCCCTTTTGTCAGCTGAGCAGTTTGTGGTTTCTATGCCCGCAAGTTTCAGGAAGTAT
TCACAAAAGAAAAATACATTTTTTCCCCCAGGGGTGGGGCAAGGACAGTGGAGAGAGTGCTAGGAAATGAGTCCCCTGGGAAAGGGGACC
GGGCCGTGATGTTAAATATCTCCGGCTCCCAAGTGACTGGATTTGCCTAGGACCTTCAGACCAACAGACTTCAGACCCTCAGACCTGCCC
CGGGGCCAGGTGGAGAAAGTGAGGGCCGTACAAGGAAGTGAAATTCTGAGTTGTTGGGGCTAAGCCTGACCCCCTCTCCATGCTCCCCGC
CCCAACCCACTCTGGCCTCAGTAGATTTTTTTTTCAGTTGTGGTTGTTGCCCAGGCTGGAGTGCAGTGGCGCCATCTTGGCTCACTGCAC
CTCCACCTTCCGGGCTCAAGCGATTCTCCAGCCTCAGCCTCCTGAGTAGCTAGGACTGCAGGTGCTCCACCACGCCCGGCTAATTTTTGT
ATTTTTAGTAGAGATGGGGTTTCCCCATGTTGGCCAGGCTGGTCTCGAACTCCTGGCCTCAGGTGTGATCCGCCCGCCTCCGCCTCCCCA
AGCGCTGAGATTACAGGTGTGAGCCACCGTGCCCAGCCCCTCAGTAGGTTTTAAGGAGCCCCCAGCCCTCCTCCCTTCTGGGCCCGACCA
GCTTATACTGCTCCATCTTCCCCGGCCACATGCCCCGCCAAGTACTGCACAGGGACCCCCCACCCAGGGGACCTGCTCCGTGAGATAATG
TGAAATACGACTGTGGACCAAACGCAATAAAACCTCTGTTTGTACGAAGAGAAG

>17666_17666_1_CNN1-CNN2_CNN1_chr19_11658722_ENST00000252456_CNN2_chr19_1036414_ENST00000263097_length(amino acids)=352AA_BP=249
MEETRVASGASKTCEEGRVCRRNFSRCLCSQRQCRHCPRQSPPASMSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRR
IGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKG
NKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKCASQSGMTAYGTRRHLYDPKNHILPPMDHSTISLQMGTNKCASQVGMTAPGTR
RHIYDTKLGTDKCDNSSMSLQMGYTQGANQSGQVFGLGRQIYDPKYCPQGTVADGAPSGTGDCPDPGEVPEYPPYYQEEAGY

--------------------------------------------------------------
>17666_17666_2_CNN1-CNN2_CNN1_chr19_11658722_ENST00000535659_CNN2_chr19_1036414_ENST00000263097_length(transcript)=2521nt_BP=929nt
ACAGCCAATGGAACGGCCCTGGAAGAGACCCGGGTCGCCTCCGGAGCTTCAAAAACATGTGAGGAGGGAAGAGTGTGCAGACGGAACTTC
AGCCGCTGCCTCTGTTCTCAGCGTCAGTGCCGCCACTGCCCCCGCCAGAGCCCACCGGCCAGCATGTCCTCTGCTCACTTCAACCGAGGC
CCTGCCTACGGGCTGTCAGCCGAGGTTAAGAACAAGGGGGAAGACTTGTTGATTTTTCCATATCCCCCGGCCTGACAAAGAAATTGGGGA
GCGCTTGAGTGCTGGGGTACCTGGGAAGTGACGCCGTGAAAGTGTGGGAGATCCTGAAGACAGAGGGGGACGGTGAAAGGCAGGAAGCGG
GCATCAGAAGTGCGGCAGGGGTCTCCTGACTGTGGAGCTAGGAAGATACCTGGACACCACCTTCATGCTATGGTTGGGTAAACTGAGGTT
CGGAGAGGAGAGGCAAATAGCTGGGGTCCCAGGTAAAGCAGCTGGCCCAGAAGTATGACCACCAGCGGGAGCAGGAGCTGAGAGAGTGGA
TCGAGGGGGTGACAGGCCGTCGCATCGGCAACAACTTCATGGACGGCCTCAAAGATGGCATCATTCTTTGCGAATTCATCAATAAGCTGC
AGCCAGGCTCCGTGAAGAAGATCAATGAGTCAACCCAAAATTGGCACCAGCTGGAGAACATCGGCAACTTCATCAAGGCCATCACCAAGT
ATGGGGTGAAGCCCCACGACATTTTTGAGGCCAACGACCTGTTTGAGAACACCAACCATACACAGGTGCAGTCCACCCTCCTGGCTTTGG
CCAGCATGGCGAAGACGAAAGGAAACAAGGTGAACGTGGGAGTGAAGTACGCAGAGAAGCAGGAGCGGAAATTCGAGCCGGGGAAGCTAA
GAGAAGGGCGGAACATCATTGGGCTGCAGATGGGCACCAACAAATGCGCCAGCCAGTCGGGCATGACTGCCTACGGCACGAGAAGGCATC
TCTATGACCCCAAGAACCATATCCTGCCCCCCATGGACCACTCGACCATCAGCCTCCAGATGGGCACGAACAAGTGTGCCAGCCAGGTGG
GCATGACGGCTCCCGGGACCCGGCGGCACATCTATGATACCAAGCTGGGAACCGACAAGTGTGACAACTCCTCCATGTCCCTGCAGATGG
GCTACACGCAGGGCGCCAACCAGAGCGGCCAGGTCTTCGGCCTGGGCCGGCAGATATATGACCCCAAGTACTGCCCGCAAGGCACAGTGG
CCGATGGGGCTCCCTCGGGCACCGGCGACTGCCCGGACCCGGGGGAGGTCCCTGAATATCCCCCTTACTACCAGGAGGAGGCCGGCTACT
GAGGCTCCCAGCACGCTCTCTCCCCACATCGTCTGCCCATCTGGGTTTTTGGGTTTTTCTGTGTTTTCATCTTTTTTTTTTTTTTCTTAA
CCCGTTCAGTGCTGCCAGTCAACCAAGGGTCTGTGAGTGTCAGCGTGGGATCAGGCAGCAGAGCTTTTTTCCCCTTTGCCTTGATCCTTC
GCAAGGCTGAGCCACTGGGCTGTGGGGGAAGGGGTCAAGGCCATATCCCAATACGTGTAGGGCGAGGGTCCCTGCTGGCACATTCAGGCT
GTGCTGGGAAGAAGAGACCTGGGCTTGGAAGGAACCGGTCCCCGACGGTTTCTGCTTGCCTCGCCTCTTCCCCCTTTTGTCAGCTGAGCA
GTTTGTGGTTTCTATGCCCGCAAGTTTCAGGAAGTATTCACAAAAGAAAAATACATTTTTTCCCCCAGGGGTGGGGCAAGGACAGTGGAG
AGAGTGCTAGGAAATGAGTCCCCTGGGAAAGGGGACCGGGCCGTGATGTTAAATATCTCCGGCTCCCAAGTGACTGGATTTGCCTAGGAC
CTTCAGACCAACAGACTTCAGACCCTCAGACCTGCCCCGGGGCCAGGTGGAGAAAGTGAGGGCCGTACAAGGAAGTGAAATTCTGAGTTG
TTGGGGCTAAGCCTGACCCCCTCTCCATGCTCCCCGCCCCAACCCACTCTGGCCTCAGTAGATTTTTTTTTCAGTTGTGGTTGTTGCCCA
GGCTGGAGTGCAGTGGCGCCATCTTGGCTCACTGCACCTCCACCTTCCGGGCTCAAGCGATTCTCCAGCCTCAGCCTCCTGAGTAGCTAG
GACTGCAGGTGCTCCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCCCCATGTTGGCCAGGCTGGTCTCGAACTCC
TGGCCTCAGGTGTGATCCGCCCGCCTCCGCCTCCCCAAGCGCTGAGATTACAGGTGTGAGCCACCGTGCCCAGCCCCTCAGTAGGTTTTA
AGGAGCCCCCAGCCCTCCTCCCTTCTGGGCCCGACCAGCTTATACTGCTCCATCTTCCCCGGCCACATGCCCCGCCAAGTACTGCACAGG
GACCCCCCACCCAGGGGACCTGCTCCGTGAGATAATGTGAAATACGACTGTGGACCAAACGCAATAAAACCTCTGTTTGTACGAAGAGAA
G

>17666_17666_2_CNN1-CNN2_CNN1_chr19_11658722_ENST00000535659_CNN2_chr19_1036414_ENST00000263097_length(amino acids)=293AA_BP=190
MGSQVKQLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHD
IFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKCASQSGMTAYGTRRHLYDPKNH
ILPPMDHSTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKCDNSSMSLQMGYTQGANQSGQVFGLGRQIYDPKYCPQGTVADGAPSG
TGDCPDPGEVPEYPPYYQEEAGY

--------------------------------------------------------------
>17666_17666_3_CNN1-CNN2_CNN1_chr19_11658722_ENST00000544952_CNN2_chr19_1036414_ENST00000263097_length(transcript)=2082nt_BP=490nt
TTTGACAGAGGGGAACACTGAGGCTCAGGGTGGCTTTTCCCAGGGTCCCATGCTGGCCCAGAAGTATGACCACCAGCGGGAGCAGGAGCT
GAGAGAGTGGATCGAGGGGGTGACAGGCCGTCGCATCGGCAACAACTTCATGGACGGCCTCAAAGATGGCATCATTCTTTGCGAATTCAT
CAATAAGCTGCAGCCAGGCTCCGTGAAGAAGATCAATGAGTCAACCCAAAATTGGCACCAGCTGGAGAACATCGGCAACTTCATCAAGGC
CATCACCAAGTATGGGGTGAAGCCCCACGACATTTTTGAGGCCAACGACCTGTTTGAGAACACCAACCATACACAGGTGCAGTCCACCCT
CCTGGCTTTGGCCAGCATGGCGAAGACGAAAGGAAACAAGGTGAACGTGGGAGTGAAGTACGCAGAGAAGCAGGAGCGGAAATTCGAGCC
GGGGAAGCTAAGAGAAGGGCGGAACATCATTGGGCTGCAGATGGGCACCAACAAATGCGCCAGCCAGTCGGGCATGACTGCCTACGGCAC
GAGAAGGCATCTCTATGACCCCAAGAACCATATCCTGCCCCCCATGGACCACTCGACCATCAGCCTCCAGATGGGCACGAACAAGTGTGC
CAGCCAGGTGGGCATGACGGCTCCCGGGACCCGGCGGCACATCTATGATACCAAGCTGGGAACCGACAAGTGTGACAACTCCTCCATGTC
CCTGCAGATGGGCTACACGCAGGGCGCCAACCAGAGCGGCCAGGTCTTCGGCCTGGGCCGGCAGATATATGACCCCAAGTACTGCCCGCA
AGGCACAGTGGCCGATGGGGCTCCCTCGGGCACCGGCGACTGCCCGGACCCGGGGGAGGTCCCTGAATATCCCCCTTACTACCAGGAGGA
GGCCGGCTACTGAGGCTCCCAGCACGCTCTCTCCCCACATCGTCTGCCCATCTGGGTTTTTGGGTTTTTCTGTGTTTTCATCTTTTTTTT
TTTTTTCTTAACCCGTTCAGTGCTGCCAGTCAACCAAGGGTCTGTGAGTGTCAGCGTGGGATCAGGCAGCAGAGCTTTTTTCCCCTTTGC
CTTGATCCTTCGCAAGGCTGAGCCACTGGGCTGTGGGGGAAGGGGTCAAGGCCATATCCCAATACGTGTAGGGCGAGGGTCCCTGCTGGC
ACATTCAGGCTGTGCTGGGAAGAAGAGACCTGGGCTTGGAAGGAACCGGTCCCCGACGGTTTCTGCTTGCCTCGCCTCTTCCCCCTTTTG
TCAGCTGAGCAGTTTGTGGTTTCTATGCCCGCAAGTTTCAGGAAGTATTCACAAAAGAAAAATACATTTTTTCCCCCAGGGGTGGGGCAA
GGACAGTGGAGAGAGTGCTAGGAAATGAGTCCCCTGGGAAAGGGGACCGGGCCGTGATGTTAAATATCTCCGGCTCCCAAGTGACTGGAT
TTGCCTAGGACCTTCAGACCAACAGACTTCAGACCCTCAGACCTGCCCCGGGGCCAGGTGGAGAAAGTGAGGGCCGTACAAGGAAGTGAA
ATTCTGAGTTGTTGGGGCTAAGCCTGACCCCCTCTCCATGCTCCCCGCCCCAACCCACTCTGGCCTCAGTAGATTTTTTTTTCAGTTGTG
GTTGTTGCCCAGGCTGGAGTGCAGTGGCGCCATCTTGGCTCACTGCACCTCCACCTTCCGGGCTCAAGCGATTCTCCAGCCTCAGCCTCC
TGAGTAGCTAGGACTGCAGGTGCTCCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCCCCATGTTGGCCAGGCTGG
TCTCGAACTCCTGGCCTCAGGTGTGATCCGCCCGCCTCCGCCTCCCCAAGCGCTGAGATTACAGGTGTGAGCCACCGTGCCCAGCCCCTC
AGTAGGTTTTAAGGAGCCCCCAGCCCTCCTCCCTTCTGGGCCCGACCAGCTTATACTGCTCCATCTTCCCCGGCCACATGCCCCGCCAAG
TACTGCACAGGGACCCCCCACCCAGGGGACCTGCTCCGTGAGATAATGTGAAATACGACTGTGGACCAAACGCAATAAAACCTCTGTTTG
TACGAAGAGAAG

>17666_17666_3_CNN1-CNN2_CNN1_chr19_11658722_ENST00000544952_CNN2_chr19_1036414_ENST00000263097_length(amino acids)=303AA_BP=200
LTEGNTEAQGGFSQGPMLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKA
ITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKCASQSGMTAYGT
RRHLYDPKNHILPPMDHSTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKCDNSSMSLQMGYTQGANQSGQVFGLGRQIYDPKYCPQ
GTVADGAPSGTGDCPDPGEVPEYPPYYQEEAGY

--------------------------------------------------------------
>17666_17666_4_CNN1-CNN2_CNN1_chr19_11658722_ENST00000592923_CNN2_chr19_1036414_ENST00000263097_length(transcript)=2520nt_BP=928nt
AGGCCCCTACAGCCAATGGAACGGCCCTGGAAGAGACCCGGGTCGCCTCCGGAGCTTCAAAAACATGTGAGGAGGGAAGAGTGTGCAGAC
GGAACTTCAGCCGCTGCCTCTGTTCTCAGCGTCAGTGCCGCCACTGCCCCCGCCAGAGCCCACCGGCCAGCATGTCCTCTGCTCACTTCA
ACCGAGGCCCTGCCTACGGGCTGTCAGCCGAGGTTAAGAACAAGGGGGAAGACTTGTTGATTTTTCCATATCCCCCGGCCTGACAAAGAA
ATTGGGGAGCGCTTGAGTGCTGGGGTACCTGGGAAGTGACGCCGTGAAAGTGTGGGAGATCCTGAAGACAGAGGGGGACGGTGAAAGGCA
GGAAGCGGGCATCAGAAGTGCGGCAGGGGTCTCCTGACTGTGGAGCTAGGAAGATACCTGGACACCACCTTCATGCTATGGTTGGGTAAA
CTGAGGTTCGGAGAGGAGAGGCAAATAGCTGGGGTCCCAGCTGGCCCAGAAGTATGACCACCAGCGGGAGCAGGAGCTGAGAGAGTGGAT
CGAGGGGGTGACAGGCCGTCGCATCGGCAACAACTTCATGGACGGCCTCAAAGATGGCATCATTCTTTGCGAATTCATCAATAAGCTGCA
GCCAGGCTCCGTGAAGAAGATCAATGAGTCAACCCAAAATTGGCACCAGCTGGAGAACATCGGCAACTTCATCAAGGCCATCACCAAGTA
TGGGGTGAAGCCCCACGACATTTTTGAGGCCAACGACCTGTTTGAGAACACCAACCATACACAGGTGCAGTCCACCCTCCTGGCTTTGGC
CAGCATGGCGAAGACGAAAGGAAACAAGGTGAACGTGGGAGTGAAGTACGCAGAGAAGCAGGAGCGGAAATTCGAGCCGGGGAAGCTAAG
AGAAGGGCGGAACATCATTGGGCTGCAGATGGGCACCAACAAATGCGCCAGCCAGTCGGGCATGACTGCCTACGGCACGAGAAGGCATCT
CTATGACCCCAAGAACCATATCCTGCCCCCCATGGACCACTCGACCATCAGCCTCCAGATGGGCACGAACAAGTGTGCCAGCCAGGTGGG
CATGACGGCTCCCGGGACCCGGCGGCACATCTATGATACCAAGCTGGGAACCGACAAGTGTGACAACTCCTCCATGTCCCTGCAGATGGG
CTACACGCAGGGCGCCAACCAGAGCGGCCAGGTCTTCGGCCTGGGCCGGCAGATATATGACCCCAAGTACTGCCCGCAAGGCACAGTGGC
CGATGGGGCTCCCTCGGGCACCGGCGACTGCCCGGACCCGGGGGAGGTCCCTGAATATCCCCCTTACTACCAGGAGGAGGCCGGCTACTG
AGGCTCCCAGCACGCTCTCTCCCCACATCGTCTGCCCATCTGGGTTTTTGGGTTTTTCTGTGTTTTCATCTTTTTTTTTTTTTTCTTAAC
CCGTTCAGTGCTGCCAGTCAACCAAGGGTCTGTGAGTGTCAGCGTGGGATCAGGCAGCAGAGCTTTTTTCCCCTTTGCCTTGATCCTTCG
CAAGGCTGAGCCACTGGGCTGTGGGGGAAGGGGTCAAGGCCATATCCCAATACGTGTAGGGCGAGGGTCCCTGCTGGCACATTCAGGCTG
TGCTGGGAAGAAGAGACCTGGGCTTGGAAGGAACCGGTCCCCGACGGTTTCTGCTTGCCTCGCCTCTTCCCCCTTTTGTCAGCTGAGCAG
TTTGTGGTTTCTATGCCCGCAAGTTTCAGGAAGTATTCACAAAAGAAAAATACATTTTTTCCCCCAGGGGTGGGGCAAGGACAGTGGAGA
GAGTGCTAGGAAATGAGTCCCCTGGGAAAGGGGACCGGGCCGTGATGTTAAATATCTCCGGCTCCCAAGTGACTGGATTTGCCTAGGACC
TTCAGACCAACAGACTTCAGACCCTCAGACCTGCCCCGGGGCCAGGTGGAGAAAGTGAGGGCCGTACAAGGAAGTGAAATTCTGAGTTGT
TGGGGCTAAGCCTGACCCCCTCTCCATGCTCCCCGCCCCAACCCACTCTGGCCTCAGTAGATTTTTTTTTCAGTTGTGGTTGTTGCCCAG
GCTGGAGTGCAGTGGCGCCATCTTGGCTCACTGCACCTCCACCTTCCGGGCTCAAGCGATTCTCCAGCCTCAGCCTCCTGAGTAGCTAGG
ACTGCAGGTGCTCCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCCCCATGTTGGCCAGGCTGGTCTCGAACTCCT
GGCCTCAGGTGTGATCCGCCCGCCTCCGCCTCCCCAAGCGCTGAGATTACAGGTGTGAGCCACCGTGCCCAGCCCCTCAGTAGGTTTTAA
GGAGCCCCCAGCCCTCCTCCCTTCTGGGCCCGACCAGCTTATACTGCTCCATCTTCCCCGGCCACATGCCCCGCCAAGTACTGCACAGGG
ACCCCCCACCCAGGGGACCTGCTCCGTGAGATAATGTGAAATACGACTGTGGACCAAACGCAATAAAACCTCTGTTTGTACGAAGAGAAG


>17666_17666_4_CNN1-CNN2_CNN1_chr19_11658722_ENST00000592923_CNN2_chr19_1036414_ENST00000263097_length(amino acids)=290AA_BP=187
MGSQLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFE
ANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKCASQSGMTAYGTRRHLYDPKNHILP
PMDHSTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKCDNSSMSLQMGYTQGANQSGQVFGLGRQIYDPKYCPQGTVADGAPSGTGD
CPDPGEVPEYPPYYQEEAGY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CNN1-CNN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CNN1-CNN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CNN1-CNN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0007134Renal Cell Carcinoma1CTD_human
TgeneC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneC1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneC1306837Papillary Renal Cell Carcinoma1CTD_human