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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:CNN2-PPP1R12C (FusionGDB2 ID:HG1265TG54776)

Fusion Gene Summary for CNN2-PPP1R12C

check button Fusion gene summary
Fusion gene informationFusion gene name: CNN2-PPP1R12C
Fusion gene ID: hg1265tg54776
HgeneTgene
Gene symbol

CNN2

PPP1R12C

Gene ID

1265

54776

Gene namecalponin 2protein phosphatase 1 regulatory subunit 12C
Synonyms-AAVS1|LENG3|MBS85|p84|p85
Cytomap('CNN2')('PPP1R12C')

19p13.3

19q13.42

Type of geneprotein-codingprotein-coding
Descriptioncalponin-2calponin H2, smooth muscleneutral calponinprotein phosphatase 1 regulatory subunit 12Cleukocyte receptor cluster (LRC) encoded novel gene 3leukocyte receptor cluster (LRC) member 3myosin-binding subunit 85protein phosphatase 1 myosin-binding subunit of 85 kDaprotein phosphatase 1 myosin-bind
Modification date2020031320200313
UniProtAcc

Q99439

.
Ensembl transtripts involved in fusion geneENST00000606983, ENST00000263097, 
ENST00000348419, ENST00000562958, 
ENST00000565096, 		ENST00000348419, 
ENST00000562958, ENST00000565096, 
ENST00000606983, ENST00000263097, 
Fusion gene scores* DoF score9 X 8 X 6=43216 X 6 X 9=864
# samples 916
** MAII scorelog2(9/432*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/864*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CNN2 [Title/Abstract] AND PPP1R12C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCNN2(1032695)-PPP1R12C(55607703), # samples:1
Anticipated loss of major functional domain due to fusion event.CNN2-PPP1R12C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CNN2-PPP1R12C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP1R12C-CNN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP1R12C-CNN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCNN2

GO:0032970

regulation of actin filament-based process

16236705

HgeneCNN2

GO:0071260

cellular response to mechanical stimulus

16236705


check buttonFusion gene breakpoints across CNN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PPP1R12C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-IP-7968-11ACNN2chr19

1032695

+PPP1R12Cchr19

55607703

-


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Fusion Gene ORF analysis for CNN2-PPP1R12C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000606983ENST00000263433CNN2chr19

1032695

+PPP1R12Cchr19

55607703

-
3UTR-3CDSENST00000606983ENST00000376393CNN2chr19

1032695

+PPP1R12Cchr19

55607703

-
3UTR-3CDSENST00000606983ENST00000435544CNN2chr19

1032695

+PPP1R12Cchr19

55607703

-
In-frameENST00000263097ENST00000263433CNN2chr19

1032695

+PPP1R12Cchr19

55607703

-
In-frameENST00000263097ENST00000376393CNN2chr19

1032695

+PPP1R12Cchr19

55607703

-
In-frameENST00000263097ENST00000435544CNN2chr19

1032695

+PPP1R12Cchr19

55607703

-
In-frameENST00000348419ENST00000263433CNN2chr19

1032695

+PPP1R12Cchr19

55607703

-
In-frameENST00000348419ENST00000376393CNN2chr19

1032695

+PPP1R12Cchr19

55607703

-
In-frameENST00000348419ENST00000435544CNN2chr19

1032695

+PPP1R12Cchr19

55607703

-
In-frameENST00000562958ENST00000263433CNN2chr19

1032695

+PPP1R12Cchr19

55607703

-
In-frameENST00000562958ENST00000376393CNN2chr19

1032695

+PPP1R12Cchr19

55607703

-
In-frameENST00000562958ENST00000435544CNN2chr19

1032695

+PPP1R12Cchr19

55607703

-
intron-3CDSENST00000565096ENST00000263433CNN2chr19

1032695

+PPP1R12Cchr19

55607703

-
intron-3CDSENST00000565096ENST00000376393CNN2chr19

1032695

+PPP1R12Cchr19

55607703

-
intron-3CDSENST00000565096ENST00000435544CNN2chr19

1032695

+PPP1R12Cchr19

55607703

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263097CNN2chr191032695+ENST00000263433PPP1R12Cchr1955607703-27107532342150638
ENST00000263097CNN2chr191032695+ENST00000376393PPP1R12Cchr1955607703-25197532341961575
ENST00000263097CNN2chr191032695+ENST00000435544PPP1R12Cchr1955607703-22597532342147637
ENST00000348419CNN2chr191032695+ENST00000263433PPP1R12Cchr1955607703-2398441511838595
ENST00000348419CNN2chr191032695+ENST00000376393PPP1R12Cchr1955607703-2207441511649532
ENST00000348419CNN2chr191032695+ENST00000435544PPP1R12Cchr1955607703-1947441511835594
ENST00000562958CNN2chr191032695+ENST00000263433PPP1R12Cchr1955607703-2380423331820595
ENST00000562958CNN2chr191032695+ENST00000376393PPP1R12Cchr1955607703-2189423331631532
ENST00000562958CNN2chr191032695+ENST00000435544PPP1R12Cchr1955607703-1929423331817594

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263097ENST00000263433CNN2chr191032695+PPP1R12Cchr1955607703-0.0314678360.96853215
ENST00000263097ENST00000376393CNN2chr191032695+PPP1R12Cchr1955607703-0.0300956870.9699043
ENST00000263097ENST00000435544CNN2chr191032695+PPP1R12Cchr1955607703-0.0365853870.9634146
ENST00000348419ENST00000263433CNN2chr191032695+PPP1R12Cchr1955607703-0.0341835580.9658164
ENST00000348419ENST00000376393CNN2chr191032695+PPP1R12Cchr1955607703-0.0318876060.9681124
ENST00000348419ENST00000435544CNN2chr191032695+PPP1R12Cchr1955607703-0.041890280.95810974
ENST00000562958ENST00000263433CNN2chr191032695+PPP1R12Cchr1955607703-0.0356305470.9643694
ENST00000562958ENST00000376393CNN2chr191032695+PPP1R12Cchr1955607703-0.032842120.96715784
ENST00000562958ENST00000435544CNN2chr191032695+PPP1R12Cchr1955607703-0.043355950.95664406

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Fusion Genomic Features for CNN2-PPP1R12C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CNN2-PPP1R12C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:1032695/chr19:55607703)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CNN2

Q99439

.
FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCNN2chr19:1032695chr19:55607703ENST00000263097+4728_132130310.0DomainCalponin-homology (CH)
HgeneCNN2chr19:1032695chr19:55607703ENST00000348419+4628_132130271.0DomainCalponin-homology (CH)
TgenePPP1R12Cchr19:1032695chr19:55607703ENST00000263433522681_782317783.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R12Cchr19:1032695chr19:55607703ENST00000263433522473_523317783.0Compositional biasPro-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCNN2chr19:1032695chr19:55607703ENST00000263097+47166_191130310.0RepeatNote=Calponin-like 1
HgeneCNN2chr19:1032695chr19:55607703ENST00000263097+47206_231130310.0RepeatNote=Calponin-like 2
HgeneCNN2chr19:1032695chr19:55607703ENST00000263097+47245_269130310.0RepeatNote=Calponin-like 3
HgeneCNN2chr19:1032695chr19:55607703ENST00000348419+46166_191130271.0RepeatNote=Calponin-like 1
HgeneCNN2chr19:1032695chr19:55607703ENST00000348419+46206_231130271.0RepeatNote=Calponin-like 2
HgeneCNN2chr19:1032695chr19:55607703ENST00000348419+46245_269130271.0RepeatNote=Calponin-like 3
TgenePPP1R12Cchr19:1032695chr19:55607703ENST00000263433522297_329317783.0Coiled coilOntology_term=ECO:0000255
TgenePPP1R12Cchr19:1032695chr19:55607703ENST00000263433522100_129317783.0RepeatANK 1
TgenePPP1R12Cchr19:1032695chr19:55607703ENST00000263433522133_162317783.0RepeatANK 2
TgenePPP1R12Cchr19:1032695chr19:55607703ENST00000263433522226_255317783.0RepeatANK 3
TgenePPP1R12Cchr19:1032695chr19:55607703ENST00000263433522259_288317783.0RepeatANK 4


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Fusion Gene Sequence for CNN2-PPP1R12C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>17676_17676_1_CNN2-PPP1R12C_CNN2_chr19_1032695_ENST00000263097_PPP1R12C_chr19_55607703_ENST00000263433_length(transcript)=2710nt_BP=753nt
GAAAGAGTGAGAGCCGCCCACGAGCTCTGAGCAGAGAGCCCGCAGGAGTGCCACGTCCCGGCGGCCTCGGCCCCTCCCTGCCTCAGTTTC
CCGTGGCATCAAAGGGGGCGAGGGGCCCCTCCAGGCCTCTGGTGACGGGGGTGCTGTGCCCAGGCGGGGGTCCGGGGGCGACCGAGGGGG
CTCAGGAAGTCCGCGGCCGCAGGAATTCGGCGCCTCCAGGCCTTATAAGGACATTTGCGCTCCGGGCCAATCAGCGGCGGGGGCGTGGCG
CGCGGAGCCCGGCGCGTCCCAACCCCGCGCCAGCCCGGCGGTCCCGTCCCGTCCCGTCCTGTGCGGCCCCGTCCCGCCGCCCGCCCGCCA
GCCATGAGCTCCACGCAGTTCAACAAGGGCCCCTCGTACGGGCTGTCGGCCGAGGTCAAGAACCGGCTCCTGTCCAAATATGACCCCCAG
AAGGAGGCAGAGCTCCGCACCTGGATCGAGGGACTCACCGGCCTCTCCATCGGCCCCGACTTCCAGAAGGGCCTGAAGGATGGAACTATC
TTATGCACACTCATGAACAAGCTACAGCCGGGCTCCGTCCCCAAGATCAACCGCTCCATGCAGAACTGGCACCAGCTAGAAAACCTGTCC
AACTTCATCAAGGCCATGGTCAGCTACGGCATGAACCCTGTGGACCTGTTCGAGGCCAACGACCTGTTTGAGAGTGGGAACATGACGCAG
GTGCAGGTGTCTCTTCTCGCCCTGGCGGGGAAGCTTCGGAACCAAAAAGAAGCTTCCCAGAGCCGGGGCCAGGAGCCCCAAGCGCCCTCT
AGCAGCAAACACAGAAGGAGCTCTGTGTGTCGTCTGAGCAGTCGCGAGAAGATTTCCCTCCAGGACTTGTCCAAGGAGCGCCGGCCTGGT
GGGGCTGGGGGGCCCCCCATCCAGGACGAGGATGAGGGGGAAGAAGGTCCCACCGAACCACCCCCTGCAGAACCCAGAACCCTCAATGGC
GTCTCCTCCCCGCCGCACCCCAGCCCTAAGAGTCCCGTGCAGCTTGAAGAGGCCCCCTTCTCCAGGCGCTTTGGCCTCCTGAAGACAGGG
AGTTCTGGTGCCCTGGGTCCCCCTGAAAGGCGGACAGCGGAGGGAGCCCCTGGGGCTGGGCTGCAGCGCTCGGCTTCCTCCTCCTGGCTG
GAAGGGACCTCCACTCAGGCCAAGGAGCTCCGTCTTGCCAGAATTACCCCGACCCCCTCCCCGAAGCTGCCGGAGCCCTCTGTCCTGTCT
GAGGTCACCAAGCCTCCTCCTTGCTTGGAGAACTCCTCGCCTCCCTCCAGGATTCCGGAGCCTGAATCCCCAGCGAAGCCAAACGTCCCC
ACAGCCTCCACGGCGCCCCCAGCGGACTCCCGGGACCGACGGAGGTCCTACCAGATGCCTGTGCGGGATGAGGAGTCGGAATCCCAGAGA
AAAGCTCGCTCCCGTCTCATGCGCCAGTCTCGGAGGTCCACACAGGGTGTGACTCTTACAGACCTGAAGGAGGCAGAGAAGGCTGCAGGG
AAGGCCCCAGAGTCAGAGAAGCCGGCGCAGAGCCTGGACCCTTCCCGAAGGCCCCGCGTCCCTGGAGTGGAGAACTCTGACAGCCCTGCC
CAGAGAGCAGAGGCGCCCGACGGGCAGGGTCCGGGACCGCAGGCGGCCAGGGAGCACCGCAAGGTCGGAAAGGAGTGGAGGGGGCCTGCG
GAGGGGGAGGAGGCGGAGCCGGCTGACCGCAGCCAGGAGTCCAGCACCCTGGAGGGCGGCCCCTCGGCCCGCAGGCAGCGGTGGCAGCGG
GACCTCAACCCAGAACCTGAGCCAGAATCGGAAGAGCCAGACGGAGGCTTTAGGACGCTGTATGCAGAGCTGCGCAGGGAGAACGAGCGG
CTTCGCGAGGCCCTGACCGAGACCACGCTGCGGCTGGCGCAGCTCAAGGTGGAGCTGGAGCGGGCCACGCAGAGGCAAGAACGCTTCGCT
GAGAGGCCAGCCCTCCTGGAACTGGAGAGATTCGAGCGCAGGGCCCTGGAACGCAAGGCCGCAGAGCTGGAGGAGGAGCTGAAGGCCCTG
TCTGACCTCCGCGCTGACAACCAGCGCCTCAAGGATGAGAATGCAGCGTTGATCCGCGTCATCAGCAAACTCTCCAAGTGACCCGGAGGG
ACTTTCCCGCACCCGTATTTATACAGCTGCTTCTGCCACACGCACCCCTTCCCCCGTGTGAACACGAGTGACAGGGCTCCGGGGGAAGTC
TCAGAGAAGCCATAGCCCCCCTGGGACCTCCGGACTGGGAGGGGAGCAGAGTCCCCAGGAGCCGAGGGGGCCACCCGAGGCCAGGATGGA
GGTGGGAGGCCGAGCCAAGCAGGGGGACGTTGCCAGAGGGGACCAGGGCCAGAGACGGGACCAGGAAGGAACTGAGGACCAAGAAGTGCA
AGGATCAGTAGCCAGGACCAGAGTGGCCGCCTGGAGGTCCCCATCTCACGTGTGATGCCACCCCGTCACCCCTCCCCTCCTGAGCAGGGA
TCCAAGAATGTGCCAAGAGTCCCGCCAGCCTCAGCCAGGTGGGCCTGTATATAGGGTCCATGTGCAATAGGGAGGGACGTCTTCTATTTT
TTGCTGCCCCCTCCCCGCCCACTGTCTGGGGCAGGGGGAGAAGGTATTTTCGAGATAAAGCACAGGCACCACAAATAAAAGTCGTGAAGT

>17676_17676_1_CNN2-PPP1R12C_CNN2_chr19_1032695_ENST00000263097_PPP1R12C_chr19_55607703_ENST00000263433_length(amino acids)=638AA_BP=173
MRSGPISGGGVARGARRVPTPRQPGGPVPSRPVRPRPAARPPAMSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIG
PDFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKLRNQKEA
SQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSSPPHPSPKSPVQLEEA
PFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVTKPPPCLENSSPPSRI
PEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRP
RVPGVENSDSPAQRAEAPDGQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQRDLNPEPEPESEEPDGGFR
TLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALLELERFERRALERKAAELEEELKALSDLRADNQRLKDENAALI

--------------------------------------------------------------
>17676_17676_2_CNN2-PPP1R12C_CNN2_chr19_1032695_ENST00000263097_PPP1R12C_chr19_55607703_ENST00000376393_length(transcript)=2519nt_BP=753nt
GAAAGAGTGAGAGCCGCCCACGAGCTCTGAGCAGAGAGCCCGCAGGAGTGCCACGTCCCGGCGGCCTCGGCCCCTCCCTGCCTCAGTTTC
CCGTGGCATCAAAGGGGGCGAGGGGCCCCTCCAGGCCTCTGGTGACGGGGGTGCTGTGCCCAGGCGGGGGTCCGGGGGCGACCGAGGGGG
CTCAGGAAGTCCGCGGCCGCAGGAATTCGGCGCCTCCAGGCCTTATAAGGACATTTGCGCTCCGGGCCAATCAGCGGCGGGGGCGTGGCG
CGCGGAGCCCGGCGCGTCCCAACCCCGCGCCAGCCCGGCGGTCCCGTCCCGTCCCGTCCTGTGCGGCCCCGTCCCGCCGCCCGCCCGCCA
GCCATGAGCTCCACGCAGTTCAACAAGGGCCCCTCGTACGGGCTGTCGGCCGAGGTCAAGAACCGGCTCCTGTCCAAATATGACCCCCAG
AAGGAGGCAGAGCTCCGCACCTGGATCGAGGGACTCACCGGCCTCTCCATCGGCCCCGACTTCCAGAAGGGCCTGAAGGATGGAACTATC
TTATGCACACTCATGAACAAGCTACAGCCGGGCTCCGTCCCCAAGATCAACCGCTCCATGCAGAACTGGCACCAGCTAGAAAACCTGTCC
AACTTCATCAAGGCCATGGTCAGCTACGGCATGAACCCTGTGGACCTGTTCGAGGCCAACGACCTGTTTGAGAGTGGGAACATGACGCAG
GTGCAGGTGTCTCTTCTCGCCCTGGCGGGGAAGCTTCGGAACCAAAAAGAAGCTTCCCAGAGCCGGGGCCAGGAGCCCCAAGCGCCCTCT
AGCAGCAAACACAGAAGGAGCTCTGTGTGTCGTCTGAGCAGTCGCGAGAAGATTTCCCTCCAGGACTTGTCCAAGGAGCGCCGGCCTGGT
GGGGCTGGGGGGCCCCCCATCCAGGACGAGGATGAGGGGGAAGAAGGTCCCACCGAACCACCCCCTGCAGAACCCAGAACCCTCAATGGC
GTCTCCTCCCCGCCGCACCCCAGCCCTAAGAGTCCCGTGCAGCTTGAAGAGGCCCCCTTCTCCAGGCGCTTTGGCCTCCTGAAGACAGGG
AGTTCTGGTGCCCTGGGTCCCCCTGAAAGGCGGACAGCGGAGGGAGCCCCTGGGGCTGGGCTGCAGCGCTCGGCTTCCTCCTCCTGGCTG
GAAGGGACCTCCACTCAGGCCAAGGAGCTCCGTCTTGCCAGAATTACCCCGACCCCCTCCCCGAAGCTGCCGGAGCCCTCTGTCCTGTCT
GAGGTCACCAAGCCTCCTCCTTGCTTGGAGAACTCCTCGCCTCCCTCCAGGATTCCGGAGCCTGAATCCCCAGCGAAGCCAAACGTCCCC
ACAGCCTCCACGGCGCCCCCAGCGGACTCCCGGGACCGACGGAGGTCCTACCAGATGCCTGTGCGGGATGAGGAGTCGGAATCCCAGAGA
AAAGCTCGCTCCCGTCTCATGCGCCAGTCTCGGAGGTCCACACAGGGTGTGACTCTTACAGACCTGAAGGAGGCAGAGAAGGCTGGGGAG
GAGGCGGAGCCGGCTGACCGCAGCCAGGAGTCCAGCACCCTGGAGGGCGGCCCCTCGGCCCGCAGGCAGCGGTGGCAGCGGGACCTCAAC
CCAGAACCTGAGCCAGAATCGGAAGAGCCAGACGGAGGCTTTAGGACGCTGTATGCAGAGCTGCGCAGGGAGAACGAGCGGCTTCGCGAG
GCCCTGACCGAGACCACGCTGCGGCTGGCGCAGCTCAAGGTGGAGCTGGAGCGGGCCACGCAGAGGCAAGAACGCTTCGCTGAGAGGCCA
GCCCTCCTGGAACTGGAGAGATTCGAGCGCAGGGCCCTGGAACGCAAGGCCGCAGAGCTGGAGGAGGAGCTGAAGGCCCTGTCTGACCTC
CGCGCTGACAACCAGCGCCTCAAGGATGAGAATGCAGCGTTGATCCGCGTCATCAGCAAACTCTCCAAGTGACCCGGAGGGACTTTCCCG
CACCCGTATTTATACAGCTGCTTCTGCCACACGCACCCCTTCCCCCGTGTGAACACGAGTGACAGGGCTCCGGGGGAAGTCTCAGAGAAG
CCATAGCCCCCCTGGGACCTCCGGACTGGGAGGGGAGCAGAGTCCCCAGGAGCCGAGGGGGCCACCCGAGGCCAGGATGGAGGTGGGAGG
CCGAGCCAAGCAGGGGGACGTTGCCAGAGGGGACCAGGGCCAGAGACGGGACCAGGAAGGAACTGAGGACCAAGAAGTGCAAGGATCAGT
AGCCAGGACCAGAGTGGCCGCCTGGAGGTCCCCATCTCACGTGTGATGCCACCCCGTCACCCCTCCCCTCCTGAGCAGGGATCCAAGAAT
GTGCCAAGAGTCCCGCCAGCCTCAGCCAGGTGGGCCTGTATATAGGGTCCATGTGCAATAGGGAGGGACGTCTTCTATTTTTTGCTGCCC

>17676_17676_2_CNN2-PPP1R12C_CNN2_chr19_1032695_ENST00000263097_PPP1R12C_chr19_55607703_ENST00000376393_length(amino acids)=575AA_BP=173
MRSGPISGGGVARGARRVPTPRQPGGPVPSRPVRPRPAARPPAMSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIG
PDFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKLRNQKEA
SQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSSPPHPSPKSPVQLEEA
PFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVTKPPPCLENSSPPSRI
PEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAGEEAEPADRSQESSTLEGGP
SARRQRWQRDLNPEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALLELERFERRALERKAA

--------------------------------------------------------------
>17676_17676_3_CNN2-PPP1R12C_CNN2_chr19_1032695_ENST00000263097_PPP1R12C_chr19_55607703_ENST00000435544_length(transcript)=2259nt_BP=753nt
GAAAGAGTGAGAGCCGCCCACGAGCTCTGAGCAGAGAGCCCGCAGGAGTGCCACGTCCCGGCGGCCTCGGCCCCTCCCTGCCTCAGTTTC
CCGTGGCATCAAAGGGGGCGAGGGGCCCCTCCAGGCCTCTGGTGACGGGGGTGCTGTGCCCAGGCGGGGGTCCGGGGGCGACCGAGGGGG
CTCAGGAAGTCCGCGGCCGCAGGAATTCGGCGCCTCCAGGCCTTATAAGGACATTTGCGCTCCGGGCCAATCAGCGGCGGGGGCGTGGCG
CGCGGAGCCCGGCGCGTCCCAACCCCGCGCCAGCCCGGCGGTCCCGTCCCGTCCCGTCCTGTGCGGCCCCGTCCCGCCGCCCGCCCGCCA
GCCATGAGCTCCACGCAGTTCAACAAGGGCCCCTCGTACGGGCTGTCGGCCGAGGTCAAGAACCGGCTCCTGTCCAAATATGACCCCCAG
AAGGAGGCAGAGCTCCGCACCTGGATCGAGGGACTCACCGGCCTCTCCATCGGCCCCGACTTCCAGAAGGGCCTGAAGGATGGAACTATC
TTATGCACACTCATGAACAAGCTACAGCCGGGCTCCGTCCCCAAGATCAACCGCTCCATGCAGAACTGGCACCAGCTAGAAAACCTGTCC
AACTTCATCAAGGCCATGGTCAGCTACGGCATGAACCCTGTGGACCTGTTCGAGGCCAACGACCTGTTTGAGAGTGGGAACATGACGCAG
GTGCAGGTGTCTCTTCTCGCCCTGGCGGGGAAGCTTCGGAACCAAAAAGAAGCTTCCCAGAGCCGGGGCCAGGAGCCCCAAGCGCCCTCT
AGCAGCAAACACAGAAGGAGCTCTGTGTGTCGTCTGAGCAGTCGCGAGAAGATTTCCCTCCAGGACTTGTCCAAGGAGCGCCGGCCTGGT
GGGGCTGGGGGGCCCCCCATCCAGGACGAGGATGAGGGGGAAGAAGGTCCCACCGAACCACCCCCTGCAGAACCCAGAACCCTCAATGGC
GTCTCCTCCCCGCCGCACCCCAGCCCTAAGAGTCCCGTGCAGCTTGAAGAGGCCCCCTTCTCCAGGCGCTTTGGCCTCCTGAAGACAGGG
AGTTCTGGTGCCCTGGGTCCCCCTGAAAGGCGGACAGCGGAGGGAGCCCCTGGGGCTGGGCTGCAGCGCTCGGCTTCCTCCTCCTGGCTG
GAAGGGACCTCCACTCAGGCCAAGGAGCTCCGTCTTGCCAGAATTACCCCGACCCCCTCCCCGAAGCTGCCGGAGCCCTCTGTCCTGTCT
GAGGTCACCAAGCCTCCTCCTTGCTTGGAGAACTCCTCGCCTCCCTCCAGGATTCCGGAGCCTGAATCCCCAGCGAAGCCAAACGTCCCC
ACAGCCTCCACGGCGCCCCCAGCGGACTCCCGGGACCGACGGAGGTCCTACCAGATGCCTGTGCGGGATGAGGAGTCGGAATCCCAGAGA
AAAGCTCGCTCCCGTCTCATGCGCCAGTCTCGGAGGTCCACACAGGGTGTGACTCTTACAGACCTGAAGGAGGCAGAGAAGGCTGCAGGG
AAGGCCCCAGAGTCAGAGAAGCCGGCGCAGAGCCTGGACCCTTCCCGAAGGCCCCGCGTCCCTGGAGTGGAGAACTCTGACAGCCCTGCC
CAGAGAGAGGCGCCCGACGGGCAGGGTCCGGGACCGCAGGCGGCCAGGGAGCACCGCAAGGTCGGAAAGGAGTGGAGGGGGCCTGCGGAG
GGGGAGGAGGCGGAGCCGGCTGACCGCAGCCAGGAGTCCAGCACCCTGGAGGGCGGCCCCTCGGCCCGCAGGCAGCGGTGGCAGCGGGAC
CTCAACCCAGAACCTGAGCCAGAATCGGAAGAGCCAGACGGAGGCTTTAGGACGCTGTATGCAGAGCTGCGCAGGGAGAACGAGCGGCTT
CGCGAGGCCCTGACCGAGACCACGCTGCGGCTGGCGCAGCTCAAGGTGGAGCTGGAGCGGGCCACGCAGAGGCAAGAACGCTTCGCTGAG
AGGCCAGCCCTCCTGGAACTGGAGAGATTCGAGCGCAGGGCCCTGGAACGCAAGGCCGCAGAGCTGGAGGAGGAGCTGAAGGCCCTGTCT
GACCTCCGCGCTGACAACCAGCGCCTCAAGGATGAGAATGCAGCGTTGATCCGCGTCATCAGCAAACTCTCCAAGTGACCCGGAGGGACT
TTCCCGCACCCGTATTTATACAGCTGCTTCTGCCACACGCACCCCTTCCCCCGTGTGAACACGAGTGACAGGGCTCCGGGGGAAGTCTCA

>17676_17676_3_CNN2-PPP1R12C_CNN2_chr19_1032695_ENST00000263097_PPP1R12C_chr19_55607703_ENST00000435544_length(amino acids)=637AA_BP=173
MRSGPISGGGVARGARRVPTPRQPGGPVPSRPVRPRPAARPPAMSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIG
PDFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKLRNQKEA
SQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSSPPHPSPKSPVQLEEA
PFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVTKPPPCLENSSPPSRI
PEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRP
RVPGVENSDSPAQREAPDGQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQRDLNPEPEPESEEPDGGFRT
LYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALLELERFERRALERKAAELEEELKALSDLRADNQRLKDENAALIR

--------------------------------------------------------------
>17676_17676_4_CNN2-PPP1R12C_CNN2_chr19_1032695_ENST00000348419_PPP1R12C_chr19_55607703_ENST00000263433_length(transcript)=2398nt_BP=441nt
CCCGTCCCGTCCCGTCCTGTGCGGCCCCGTCCCGCCGCCCGCCCGCCAGCCATGAGCTCCACGCAGTTCAACAAGGGCCCCTCGTACGGG
CTGTCGGCCGAGGTCAAGAACCGGCTCCTGTCCAAATATGACCCCCAGAAGGAGGCAGAGCTCCGCACCTGGATCGAGGGACTCACCGGC
CTCTCCATCGGCCCCGACTTCCAGAAGGGCCTGAAGGATGGAACTATCTTATGCACACTCATGAACAAGCTACAGCCGGGCTCCGTCCCC
AAGATCAACCGCTCCATGCAGAACTGGCACCAGCTAGAAAACCTGTCCAACTTCATCAAGGCCATGGTCAGCTACGGCATGAACCCTGTG
GACCTGTTCGAGGCCAACGACCTGTTTGAGAGTGGGAACATGACGCAGGTGCAGGTGTCTCTTCTCGCCCTGGCGGGGAAGCTTCGGAAC
CAAAAAGAAGCTTCCCAGAGCCGGGGCCAGGAGCCCCAAGCGCCCTCTAGCAGCAAACACAGAAGGAGCTCTGTGTGTCGTCTGAGCAGT
CGCGAGAAGATTTCCCTCCAGGACTTGTCCAAGGAGCGCCGGCCTGGTGGGGCTGGGGGGCCCCCCATCCAGGACGAGGATGAGGGGGAA
GAAGGTCCCACCGAACCACCCCCTGCAGAACCCAGAACCCTCAATGGCGTCTCCTCCCCGCCGCACCCCAGCCCTAAGAGTCCCGTGCAG
CTTGAAGAGGCCCCCTTCTCCAGGCGCTTTGGCCTCCTGAAGACAGGGAGTTCTGGTGCCCTGGGTCCCCCTGAAAGGCGGACAGCGGAG
GGAGCCCCTGGGGCTGGGCTGCAGCGCTCGGCTTCCTCCTCCTGGCTGGAAGGGACCTCCACTCAGGCCAAGGAGCTCCGTCTTGCCAGA
ATTACCCCGACCCCCTCCCCGAAGCTGCCGGAGCCCTCTGTCCTGTCTGAGGTCACCAAGCCTCCTCCTTGCTTGGAGAACTCCTCGCCT
CCCTCCAGGATTCCGGAGCCTGAATCCCCAGCGAAGCCAAACGTCCCCACAGCCTCCACGGCGCCCCCAGCGGACTCCCGGGACCGACGG
AGGTCCTACCAGATGCCTGTGCGGGATGAGGAGTCGGAATCCCAGAGAAAAGCTCGCTCCCGTCTCATGCGCCAGTCTCGGAGGTCCACA
CAGGGTGTGACTCTTACAGACCTGAAGGAGGCAGAGAAGGCTGCAGGGAAGGCCCCAGAGTCAGAGAAGCCGGCGCAGAGCCTGGACCCT
TCCCGAAGGCCCCGCGTCCCTGGAGTGGAGAACTCTGACAGCCCTGCCCAGAGAGCAGAGGCGCCCGACGGGCAGGGTCCGGGACCGCAG
GCGGCCAGGGAGCACCGCAAGGTCGGAAAGGAGTGGAGGGGGCCTGCGGAGGGGGAGGAGGCGGAGCCGGCTGACCGCAGCCAGGAGTCC
AGCACCCTGGAGGGCGGCCCCTCGGCCCGCAGGCAGCGGTGGCAGCGGGACCTCAACCCAGAACCTGAGCCAGAATCGGAAGAGCCAGAC
GGAGGCTTTAGGACGCTGTATGCAGAGCTGCGCAGGGAGAACGAGCGGCTTCGCGAGGCCCTGACCGAGACCACGCTGCGGCTGGCGCAG
CTCAAGGTGGAGCTGGAGCGGGCCACGCAGAGGCAAGAACGCTTCGCTGAGAGGCCAGCCCTCCTGGAACTGGAGAGATTCGAGCGCAGG
GCCCTGGAACGCAAGGCCGCAGAGCTGGAGGAGGAGCTGAAGGCCCTGTCTGACCTCCGCGCTGACAACCAGCGCCTCAAGGATGAGAAT
GCAGCGTTGATCCGCGTCATCAGCAAACTCTCCAAGTGACCCGGAGGGACTTTCCCGCACCCGTATTTATACAGCTGCTTCTGCCACACG
CACCCCTTCCCCCGTGTGAACACGAGTGACAGGGCTCCGGGGGAAGTCTCAGAGAAGCCATAGCCCCCCTGGGACCTCCGGACTGGGAGG
GGAGCAGAGTCCCCAGGAGCCGAGGGGGCCACCCGAGGCCAGGATGGAGGTGGGAGGCCGAGCCAAGCAGGGGGACGTTGCCAGAGGGGA
CCAGGGCCAGAGACGGGACCAGGAAGGAACTGAGGACCAAGAAGTGCAAGGATCAGTAGCCAGGACCAGAGTGGCCGCCTGGAGGTCCCC
ATCTCACGTGTGATGCCACCCCGTCACCCCTCCCCTCCTGAGCAGGGATCCAAGAATGTGCCAAGAGTCCCGCCAGCCTCAGCCAGGTGG
GCCTGTATATAGGGTCCATGTGCAATAGGGAGGGACGTCTTCTATTTTTTGCTGCCCCCTCCCCGCCCACTGTCTGGGGCAGGGGGAGAA

>17676_17676_4_CNN2-PPP1R12C_CNN2_chr19_1032695_ENST00000348419_PPP1R12C_chr19_55607703_ENST00000263433_length(amino acids)=595AA_BP=130
MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSN
FIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGG
AGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSSPPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLE
GTSTQAKELRLARITPTPSPKLPEPSVLSEVTKPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRK
ARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVENSDSPAQRAEAPDGQGPGPQAAREHRKVGKEWRGPAE
GEEAEPADRSQESSTLEGGPSARRQRWQRDLNPEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAE

--------------------------------------------------------------
>17676_17676_5_CNN2-PPP1R12C_CNN2_chr19_1032695_ENST00000348419_PPP1R12C_chr19_55607703_ENST00000376393_length(transcript)=2207nt_BP=441nt
CCCGTCCCGTCCCGTCCTGTGCGGCCCCGTCCCGCCGCCCGCCCGCCAGCCATGAGCTCCACGCAGTTCAACAAGGGCCCCTCGTACGGG
CTGTCGGCCGAGGTCAAGAACCGGCTCCTGTCCAAATATGACCCCCAGAAGGAGGCAGAGCTCCGCACCTGGATCGAGGGACTCACCGGC
CTCTCCATCGGCCCCGACTTCCAGAAGGGCCTGAAGGATGGAACTATCTTATGCACACTCATGAACAAGCTACAGCCGGGCTCCGTCCCC
AAGATCAACCGCTCCATGCAGAACTGGCACCAGCTAGAAAACCTGTCCAACTTCATCAAGGCCATGGTCAGCTACGGCATGAACCCTGTG
GACCTGTTCGAGGCCAACGACCTGTTTGAGAGTGGGAACATGACGCAGGTGCAGGTGTCTCTTCTCGCCCTGGCGGGGAAGCTTCGGAAC
CAAAAAGAAGCTTCCCAGAGCCGGGGCCAGGAGCCCCAAGCGCCCTCTAGCAGCAAACACAGAAGGAGCTCTGTGTGTCGTCTGAGCAGT
CGCGAGAAGATTTCCCTCCAGGACTTGTCCAAGGAGCGCCGGCCTGGTGGGGCTGGGGGGCCCCCCATCCAGGACGAGGATGAGGGGGAA
GAAGGTCCCACCGAACCACCCCCTGCAGAACCCAGAACCCTCAATGGCGTCTCCTCCCCGCCGCACCCCAGCCCTAAGAGTCCCGTGCAG
CTTGAAGAGGCCCCCTTCTCCAGGCGCTTTGGCCTCCTGAAGACAGGGAGTTCTGGTGCCCTGGGTCCCCCTGAAAGGCGGACAGCGGAG
GGAGCCCCTGGGGCTGGGCTGCAGCGCTCGGCTTCCTCCTCCTGGCTGGAAGGGACCTCCACTCAGGCCAAGGAGCTCCGTCTTGCCAGA
ATTACCCCGACCCCCTCCCCGAAGCTGCCGGAGCCCTCTGTCCTGTCTGAGGTCACCAAGCCTCCTCCTTGCTTGGAGAACTCCTCGCCT
CCCTCCAGGATTCCGGAGCCTGAATCCCCAGCGAAGCCAAACGTCCCCACAGCCTCCACGGCGCCCCCAGCGGACTCCCGGGACCGACGG
AGGTCCTACCAGATGCCTGTGCGGGATGAGGAGTCGGAATCCCAGAGAAAAGCTCGCTCCCGTCTCATGCGCCAGTCTCGGAGGTCCACA
CAGGGTGTGACTCTTACAGACCTGAAGGAGGCAGAGAAGGCTGGGGAGGAGGCGGAGCCGGCTGACCGCAGCCAGGAGTCCAGCACCCTG
GAGGGCGGCCCCTCGGCCCGCAGGCAGCGGTGGCAGCGGGACCTCAACCCAGAACCTGAGCCAGAATCGGAAGAGCCAGACGGAGGCTTT
AGGACGCTGTATGCAGAGCTGCGCAGGGAGAACGAGCGGCTTCGCGAGGCCCTGACCGAGACCACGCTGCGGCTGGCGCAGCTCAAGGTG
GAGCTGGAGCGGGCCACGCAGAGGCAAGAACGCTTCGCTGAGAGGCCAGCCCTCCTGGAACTGGAGAGATTCGAGCGCAGGGCCCTGGAA
CGCAAGGCCGCAGAGCTGGAGGAGGAGCTGAAGGCCCTGTCTGACCTCCGCGCTGACAACCAGCGCCTCAAGGATGAGAATGCAGCGTTG
ATCCGCGTCATCAGCAAACTCTCCAAGTGACCCGGAGGGACTTTCCCGCACCCGTATTTATACAGCTGCTTCTGCCACACGCACCCCTTC
CCCCGTGTGAACACGAGTGACAGGGCTCCGGGGGAAGTCTCAGAGAAGCCATAGCCCCCCTGGGACCTCCGGACTGGGAGGGGAGCAGAG
TCCCCAGGAGCCGAGGGGGCCACCCGAGGCCAGGATGGAGGTGGGAGGCCGAGCCAAGCAGGGGGACGTTGCCAGAGGGGACCAGGGCCA
GAGACGGGACCAGGAAGGAACTGAGGACCAAGAAGTGCAAGGATCAGTAGCCAGGACCAGAGTGGCCGCCTGGAGGTCCCCATCTCACGT
GTGATGCCACCCCGTCACCCCTCCCCTCCTGAGCAGGGATCCAAGAATGTGCCAAGAGTCCCGCCAGCCTCAGCCAGGTGGGCCTGTATA
TAGGGTCCATGTGCAATAGGGAGGGACGTCTTCTATTTTTTGCTGCCCCCTCCCCGCCCACTGTCTGGGGCAGGGGGAGAAGGTATTTTC

>17676_17676_5_CNN2-PPP1R12C_CNN2_chr19_1032695_ENST00000348419_PPP1R12C_chr19_55607703_ENST00000376393_length(amino acids)=532AA_BP=130
MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSN
FIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGG
AGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSSPPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLE
GTSTQAKELRLARITPTPSPKLPEPSVLSEVTKPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRK
ARSRLMRQSRRSTQGVTLTDLKEAEKAGEEAEPADRSQESSTLEGGPSARRQRWQRDLNPEPEPESEEPDGGFRTLYAELRRENERLREA

--------------------------------------------------------------
>17676_17676_6_CNN2-PPP1R12C_CNN2_chr19_1032695_ENST00000348419_PPP1R12C_chr19_55607703_ENST00000435544_length(transcript)=1947nt_BP=441nt
CCCGTCCCGTCCCGTCCTGTGCGGCCCCGTCCCGCCGCCCGCCCGCCAGCCATGAGCTCCACGCAGTTCAACAAGGGCCCCTCGTACGGG
CTGTCGGCCGAGGTCAAGAACCGGCTCCTGTCCAAATATGACCCCCAGAAGGAGGCAGAGCTCCGCACCTGGATCGAGGGACTCACCGGC
CTCTCCATCGGCCCCGACTTCCAGAAGGGCCTGAAGGATGGAACTATCTTATGCACACTCATGAACAAGCTACAGCCGGGCTCCGTCCCC
AAGATCAACCGCTCCATGCAGAACTGGCACCAGCTAGAAAACCTGTCCAACTTCATCAAGGCCATGGTCAGCTACGGCATGAACCCTGTG
GACCTGTTCGAGGCCAACGACCTGTTTGAGAGTGGGAACATGACGCAGGTGCAGGTGTCTCTTCTCGCCCTGGCGGGGAAGCTTCGGAAC
CAAAAAGAAGCTTCCCAGAGCCGGGGCCAGGAGCCCCAAGCGCCCTCTAGCAGCAAACACAGAAGGAGCTCTGTGTGTCGTCTGAGCAGT
CGCGAGAAGATTTCCCTCCAGGACTTGTCCAAGGAGCGCCGGCCTGGTGGGGCTGGGGGGCCCCCCATCCAGGACGAGGATGAGGGGGAA
GAAGGTCCCACCGAACCACCCCCTGCAGAACCCAGAACCCTCAATGGCGTCTCCTCCCCGCCGCACCCCAGCCCTAAGAGTCCCGTGCAG
CTTGAAGAGGCCCCCTTCTCCAGGCGCTTTGGCCTCCTGAAGACAGGGAGTTCTGGTGCCCTGGGTCCCCCTGAAAGGCGGACAGCGGAG
GGAGCCCCTGGGGCTGGGCTGCAGCGCTCGGCTTCCTCCTCCTGGCTGGAAGGGACCTCCACTCAGGCCAAGGAGCTCCGTCTTGCCAGA
ATTACCCCGACCCCCTCCCCGAAGCTGCCGGAGCCCTCTGTCCTGTCTGAGGTCACCAAGCCTCCTCCTTGCTTGGAGAACTCCTCGCCT
CCCTCCAGGATTCCGGAGCCTGAATCCCCAGCGAAGCCAAACGTCCCCACAGCCTCCACGGCGCCCCCAGCGGACTCCCGGGACCGACGG
AGGTCCTACCAGATGCCTGTGCGGGATGAGGAGTCGGAATCCCAGAGAAAAGCTCGCTCCCGTCTCATGCGCCAGTCTCGGAGGTCCACA
CAGGGTGTGACTCTTACAGACCTGAAGGAGGCAGAGAAGGCTGCAGGGAAGGCCCCAGAGTCAGAGAAGCCGGCGCAGAGCCTGGACCCT
TCCCGAAGGCCCCGCGTCCCTGGAGTGGAGAACTCTGACAGCCCTGCCCAGAGAGAGGCGCCCGACGGGCAGGGTCCGGGACCGCAGGCG
GCCAGGGAGCACCGCAAGGTCGGAAAGGAGTGGAGGGGGCCTGCGGAGGGGGAGGAGGCGGAGCCGGCTGACCGCAGCCAGGAGTCCAGC
ACCCTGGAGGGCGGCCCCTCGGCCCGCAGGCAGCGGTGGCAGCGGGACCTCAACCCAGAACCTGAGCCAGAATCGGAAGAGCCAGACGGA
GGCTTTAGGACGCTGTATGCAGAGCTGCGCAGGGAGAACGAGCGGCTTCGCGAGGCCCTGACCGAGACCACGCTGCGGCTGGCGCAGCTC
AAGGTGGAGCTGGAGCGGGCCACGCAGAGGCAAGAACGCTTCGCTGAGAGGCCAGCCCTCCTGGAACTGGAGAGATTCGAGCGCAGGGCC
CTGGAACGCAAGGCCGCAGAGCTGGAGGAGGAGCTGAAGGCCCTGTCTGACCTCCGCGCTGACAACCAGCGCCTCAAGGATGAGAATGCA
GCGTTGATCCGCGTCATCAGCAAACTCTCCAAGTGACCCGGAGGGACTTTCCCGCACCCGTATTTATACAGCTGCTTCTGCCACACGCAC

>17676_17676_6_CNN2-PPP1R12C_CNN2_chr19_1032695_ENST00000348419_PPP1R12C_chr19_55607703_ENST00000435544_length(amino acids)=594AA_BP=130
MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSN
FIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGG
AGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSSPPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLE
GTSTQAKELRLARITPTPSPKLPEPSVLSEVTKPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRK
ARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVENSDSPAQREAPDGQGPGPQAAREHRKVGKEWRGPAEG
EEAEPADRSQESSTLEGGPSARRQRWQRDLNPEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAER

--------------------------------------------------------------
>17676_17676_7_CNN2-PPP1R12C_CNN2_chr19_1032695_ENST00000562958_PPP1R12C_chr19_55607703_ENST00000263433_length(transcript)=2380nt_BP=423nt
GTGCGGCCCCGTCCCGCCGCCCGCCCGCCAGCCATGAGCTCCACGCAGTTCAACAAGGGCCCCTCGTACGGGCTGTCGGCCGAGGTCAAG
AACCGGCTCCTGTCCAAATATGACCCCCAGAAGGAGGCAGAGCTCCGCACCTGGATCGAGGGACTCACCGGCCTCTCCATCGGCCCCGAC
TTCCAGAAGGGCCTGAAGGATGGAACTATCTTATGCACACTCATGAACAAGCTACAGCCGGGCTCCGTCCCCAAGATCAACCGCTCCATG
CAGAACTGGCACCAGCTAGAAAACCTGTCCAACTTCATCAAGGCCATGGTCAGCTACGGCATGAACCCTGTGGACCTGTTCGAGGCCAAC
GACCTGTTTGAGAGTGGGAACATGACGCAGGTGCAGGTGTCTCTTCTCGCCCTGGCGGGGAAGCTTCGGAACCAAAAAGAAGCTTCCCAG
AGCCGGGGCCAGGAGCCCCAAGCGCCCTCTAGCAGCAAACACAGAAGGAGCTCTGTGTGTCGTCTGAGCAGTCGCGAGAAGATTTCCCTC
CAGGACTTGTCCAAGGAGCGCCGGCCTGGTGGGGCTGGGGGGCCCCCCATCCAGGACGAGGATGAGGGGGAAGAAGGTCCCACCGAACCA
CCCCCTGCAGAACCCAGAACCCTCAATGGCGTCTCCTCCCCGCCGCACCCCAGCCCTAAGAGTCCCGTGCAGCTTGAAGAGGCCCCCTTC
TCCAGGCGCTTTGGCCTCCTGAAGACAGGGAGTTCTGGTGCCCTGGGTCCCCCTGAAAGGCGGACAGCGGAGGGAGCCCCTGGGGCTGGG
CTGCAGCGCTCGGCTTCCTCCTCCTGGCTGGAAGGGACCTCCACTCAGGCCAAGGAGCTCCGTCTTGCCAGAATTACCCCGACCCCCTCC
CCGAAGCTGCCGGAGCCCTCTGTCCTGTCTGAGGTCACCAAGCCTCCTCCTTGCTTGGAGAACTCCTCGCCTCCCTCCAGGATTCCGGAG
CCTGAATCCCCAGCGAAGCCAAACGTCCCCACAGCCTCCACGGCGCCCCCAGCGGACTCCCGGGACCGACGGAGGTCCTACCAGATGCCT
GTGCGGGATGAGGAGTCGGAATCCCAGAGAAAAGCTCGCTCCCGTCTCATGCGCCAGTCTCGGAGGTCCACACAGGGTGTGACTCTTACA
GACCTGAAGGAGGCAGAGAAGGCTGCAGGGAAGGCCCCAGAGTCAGAGAAGCCGGCGCAGAGCCTGGACCCTTCCCGAAGGCCCCGCGTC
CCTGGAGTGGAGAACTCTGACAGCCCTGCCCAGAGAGCAGAGGCGCCCGACGGGCAGGGTCCGGGACCGCAGGCGGCCAGGGAGCACCGC
AAGGTCGGAAAGGAGTGGAGGGGGCCTGCGGAGGGGGAGGAGGCGGAGCCGGCTGACCGCAGCCAGGAGTCCAGCACCCTGGAGGGCGGC
CCCTCGGCCCGCAGGCAGCGGTGGCAGCGGGACCTCAACCCAGAACCTGAGCCAGAATCGGAAGAGCCAGACGGAGGCTTTAGGACGCTG
TATGCAGAGCTGCGCAGGGAGAACGAGCGGCTTCGCGAGGCCCTGACCGAGACCACGCTGCGGCTGGCGCAGCTCAAGGTGGAGCTGGAG
CGGGCCACGCAGAGGCAAGAACGCTTCGCTGAGAGGCCAGCCCTCCTGGAACTGGAGAGATTCGAGCGCAGGGCCCTGGAACGCAAGGCC
GCAGAGCTGGAGGAGGAGCTGAAGGCCCTGTCTGACCTCCGCGCTGACAACCAGCGCCTCAAGGATGAGAATGCAGCGTTGATCCGCGTC
ATCAGCAAACTCTCCAAGTGACCCGGAGGGACTTTCCCGCACCCGTATTTATACAGCTGCTTCTGCCACACGCACCCCTTCCCCCGTGTG
AACACGAGTGACAGGGCTCCGGGGGAAGTCTCAGAGAAGCCATAGCCCCCCTGGGACCTCCGGACTGGGAGGGGAGCAGAGTCCCCAGGA
GCCGAGGGGGCCACCCGAGGCCAGGATGGAGGTGGGAGGCCGAGCCAAGCAGGGGGACGTTGCCAGAGGGGACCAGGGCCAGAGACGGGA
CCAGGAAGGAACTGAGGACCAAGAAGTGCAAGGATCAGTAGCCAGGACCAGAGTGGCCGCCTGGAGGTCCCCATCTCACGTGTGATGCCA
CCCCGTCACCCCTCCCCTCCTGAGCAGGGATCCAAGAATGTGCCAAGAGTCCCGCCAGCCTCAGCCAGGTGGGCCTGTATATAGGGTCCA
TGTGCAATAGGGAGGGACGTCTTCTATTTTTTGCTGCCCCCTCCCCGCCCACTGTCTGGGGCAGGGGGAGAAGGTATTTTCGAGATAAAG

>17676_17676_7_CNN2-PPP1R12C_CNN2_chr19_1032695_ENST00000562958_PPP1R12C_chr19_55607703_ENST00000263433_length(amino acids)=595AA_BP=130
MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSN
FIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGG
AGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSSPPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLE
GTSTQAKELRLARITPTPSPKLPEPSVLSEVTKPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRK
ARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVENSDSPAQRAEAPDGQGPGPQAAREHRKVGKEWRGPAE
GEEAEPADRSQESSTLEGGPSARRQRWQRDLNPEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAE

--------------------------------------------------------------
>17676_17676_8_CNN2-PPP1R12C_CNN2_chr19_1032695_ENST00000562958_PPP1R12C_chr19_55607703_ENST00000376393_length(transcript)=2189nt_BP=423nt
GTGCGGCCCCGTCCCGCCGCCCGCCCGCCAGCCATGAGCTCCACGCAGTTCAACAAGGGCCCCTCGTACGGGCTGTCGGCCGAGGTCAAG
AACCGGCTCCTGTCCAAATATGACCCCCAGAAGGAGGCAGAGCTCCGCACCTGGATCGAGGGACTCACCGGCCTCTCCATCGGCCCCGAC
TTCCAGAAGGGCCTGAAGGATGGAACTATCTTATGCACACTCATGAACAAGCTACAGCCGGGCTCCGTCCCCAAGATCAACCGCTCCATG
CAGAACTGGCACCAGCTAGAAAACCTGTCCAACTTCATCAAGGCCATGGTCAGCTACGGCATGAACCCTGTGGACCTGTTCGAGGCCAAC
GACCTGTTTGAGAGTGGGAACATGACGCAGGTGCAGGTGTCTCTTCTCGCCCTGGCGGGGAAGCTTCGGAACCAAAAAGAAGCTTCCCAG
AGCCGGGGCCAGGAGCCCCAAGCGCCCTCTAGCAGCAAACACAGAAGGAGCTCTGTGTGTCGTCTGAGCAGTCGCGAGAAGATTTCCCTC
CAGGACTTGTCCAAGGAGCGCCGGCCTGGTGGGGCTGGGGGGCCCCCCATCCAGGACGAGGATGAGGGGGAAGAAGGTCCCACCGAACCA
CCCCCTGCAGAACCCAGAACCCTCAATGGCGTCTCCTCCCCGCCGCACCCCAGCCCTAAGAGTCCCGTGCAGCTTGAAGAGGCCCCCTTC
TCCAGGCGCTTTGGCCTCCTGAAGACAGGGAGTTCTGGTGCCCTGGGTCCCCCTGAAAGGCGGACAGCGGAGGGAGCCCCTGGGGCTGGG
CTGCAGCGCTCGGCTTCCTCCTCCTGGCTGGAAGGGACCTCCACTCAGGCCAAGGAGCTCCGTCTTGCCAGAATTACCCCGACCCCCTCC
CCGAAGCTGCCGGAGCCCTCTGTCCTGTCTGAGGTCACCAAGCCTCCTCCTTGCTTGGAGAACTCCTCGCCTCCCTCCAGGATTCCGGAG
CCTGAATCCCCAGCGAAGCCAAACGTCCCCACAGCCTCCACGGCGCCCCCAGCGGACTCCCGGGACCGACGGAGGTCCTACCAGATGCCT
GTGCGGGATGAGGAGTCGGAATCCCAGAGAAAAGCTCGCTCCCGTCTCATGCGCCAGTCTCGGAGGTCCACACAGGGTGTGACTCTTACA
GACCTGAAGGAGGCAGAGAAGGCTGGGGAGGAGGCGGAGCCGGCTGACCGCAGCCAGGAGTCCAGCACCCTGGAGGGCGGCCCCTCGGCC
CGCAGGCAGCGGTGGCAGCGGGACCTCAACCCAGAACCTGAGCCAGAATCGGAAGAGCCAGACGGAGGCTTTAGGACGCTGTATGCAGAG
CTGCGCAGGGAGAACGAGCGGCTTCGCGAGGCCCTGACCGAGACCACGCTGCGGCTGGCGCAGCTCAAGGTGGAGCTGGAGCGGGCCACG
CAGAGGCAAGAACGCTTCGCTGAGAGGCCAGCCCTCCTGGAACTGGAGAGATTCGAGCGCAGGGCCCTGGAACGCAAGGCCGCAGAGCTG
GAGGAGGAGCTGAAGGCCCTGTCTGACCTCCGCGCTGACAACCAGCGCCTCAAGGATGAGAATGCAGCGTTGATCCGCGTCATCAGCAAA
CTCTCCAAGTGACCCGGAGGGACTTTCCCGCACCCGTATTTATACAGCTGCTTCTGCCACACGCACCCCTTCCCCCGTGTGAACACGAGT
GACAGGGCTCCGGGGGAAGTCTCAGAGAAGCCATAGCCCCCCTGGGACCTCCGGACTGGGAGGGGAGCAGAGTCCCCAGGAGCCGAGGGG
GCCACCCGAGGCCAGGATGGAGGTGGGAGGCCGAGCCAAGCAGGGGGACGTTGCCAGAGGGGACCAGGGCCAGAGACGGGACCAGGAAGG
AACTGAGGACCAAGAAGTGCAAGGATCAGTAGCCAGGACCAGAGTGGCCGCCTGGAGGTCCCCATCTCACGTGTGATGCCACCCCGTCAC
CCCTCCCCTCCTGAGCAGGGATCCAAGAATGTGCCAAGAGTCCCGCCAGCCTCAGCCAGGTGGGCCTGTATATAGGGTCCATGTGCAATA
GGGAGGGACGTCTTCTATTTTTTGCTGCCCCCTCCCCGCCCACTGTCTGGGGCAGGGGGAGAAGGTATTTTCGAGATAAAGCACAGGCAC

>17676_17676_8_CNN2-PPP1R12C_CNN2_chr19_1032695_ENST00000562958_PPP1R12C_chr19_55607703_ENST00000376393_length(amino acids)=532AA_BP=130
MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSN
FIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGG
AGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSSPPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLE
GTSTQAKELRLARITPTPSPKLPEPSVLSEVTKPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRK
ARSRLMRQSRRSTQGVTLTDLKEAEKAGEEAEPADRSQESSTLEGGPSARRQRWQRDLNPEPEPESEEPDGGFRTLYAELRRENERLREA

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>17676_17676_9_CNN2-PPP1R12C_CNN2_chr19_1032695_ENST00000562958_PPP1R12C_chr19_55607703_ENST00000435544_length(transcript)=1929nt_BP=423nt
GTGCGGCCCCGTCCCGCCGCCCGCCCGCCAGCCATGAGCTCCACGCAGTTCAACAAGGGCCCCTCGTACGGGCTGTCGGCCGAGGTCAAG
AACCGGCTCCTGTCCAAATATGACCCCCAGAAGGAGGCAGAGCTCCGCACCTGGATCGAGGGACTCACCGGCCTCTCCATCGGCCCCGAC
TTCCAGAAGGGCCTGAAGGATGGAACTATCTTATGCACACTCATGAACAAGCTACAGCCGGGCTCCGTCCCCAAGATCAACCGCTCCATG
CAGAACTGGCACCAGCTAGAAAACCTGTCCAACTTCATCAAGGCCATGGTCAGCTACGGCATGAACCCTGTGGACCTGTTCGAGGCCAAC
GACCTGTTTGAGAGTGGGAACATGACGCAGGTGCAGGTGTCTCTTCTCGCCCTGGCGGGGAAGCTTCGGAACCAAAAAGAAGCTTCCCAG
AGCCGGGGCCAGGAGCCCCAAGCGCCCTCTAGCAGCAAACACAGAAGGAGCTCTGTGTGTCGTCTGAGCAGTCGCGAGAAGATTTCCCTC
CAGGACTTGTCCAAGGAGCGCCGGCCTGGTGGGGCTGGGGGGCCCCCCATCCAGGACGAGGATGAGGGGGAAGAAGGTCCCACCGAACCA
CCCCCTGCAGAACCCAGAACCCTCAATGGCGTCTCCTCCCCGCCGCACCCCAGCCCTAAGAGTCCCGTGCAGCTTGAAGAGGCCCCCTTC
TCCAGGCGCTTTGGCCTCCTGAAGACAGGGAGTTCTGGTGCCCTGGGTCCCCCTGAAAGGCGGACAGCGGAGGGAGCCCCTGGGGCTGGG
CTGCAGCGCTCGGCTTCCTCCTCCTGGCTGGAAGGGACCTCCACTCAGGCCAAGGAGCTCCGTCTTGCCAGAATTACCCCGACCCCCTCC
CCGAAGCTGCCGGAGCCCTCTGTCCTGTCTGAGGTCACCAAGCCTCCTCCTTGCTTGGAGAACTCCTCGCCTCCCTCCAGGATTCCGGAG
CCTGAATCCCCAGCGAAGCCAAACGTCCCCACAGCCTCCACGGCGCCCCCAGCGGACTCCCGGGACCGACGGAGGTCCTACCAGATGCCT
GTGCGGGATGAGGAGTCGGAATCCCAGAGAAAAGCTCGCTCCCGTCTCATGCGCCAGTCTCGGAGGTCCACACAGGGTGTGACTCTTACA
GACCTGAAGGAGGCAGAGAAGGCTGCAGGGAAGGCCCCAGAGTCAGAGAAGCCGGCGCAGAGCCTGGACCCTTCCCGAAGGCCCCGCGTC
CCTGGAGTGGAGAACTCTGACAGCCCTGCCCAGAGAGAGGCGCCCGACGGGCAGGGTCCGGGACCGCAGGCGGCCAGGGAGCACCGCAAG
GTCGGAAAGGAGTGGAGGGGGCCTGCGGAGGGGGAGGAGGCGGAGCCGGCTGACCGCAGCCAGGAGTCCAGCACCCTGGAGGGCGGCCCC
TCGGCCCGCAGGCAGCGGTGGCAGCGGGACCTCAACCCAGAACCTGAGCCAGAATCGGAAGAGCCAGACGGAGGCTTTAGGACGCTGTAT
GCAGAGCTGCGCAGGGAGAACGAGCGGCTTCGCGAGGCCCTGACCGAGACCACGCTGCGGCTGGCGCAGCTCAAGGTGGAGCTGGAGCGG
GCCACGCAGAGGCAAGAACGCTTCGCTGAGAGGCCAGCCCTCCTGGAACTGGAGAGATTCGAGCGCAGGGCCCTGGAACGCAAGGCCGCA
GAGCTGGAGGAGGAGCTGAAGGCCCTGTCTGACCTCCGCGCTGACAACCAGCGCCTCAAGGATGAGAATGCAGCGTTGATCCGCGTCATC
AGCAAACTCTCCAAGTGACCCGGAGGGACTTTCCCGCACCCGTATTTATACAGCTGCTTCTGCCACACGCACCCCTTCCCCCGTGTGAAC

>17676_17676_9_CNN2-PPP1R12C_CNN2_chr19_1032695_ENST00000562958_PPP1R12C_chr19_55607703_ENST00000435544_length(amino acids)=594AA_BP=130
MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSN
FIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGG
AGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSSPPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLE
GTSTQAKELRLARITPTPSPKLPEPSVLSEVTKPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRK
ARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVENSDSPAQREAPDGQGPGPQAAREHRKVGKEWRGPAEG
EEAEPADRSQESSTLEGGPSARRQRWQRDLNPEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAER

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Fusion Gene PPI Analysis for CNN2-PPP1R12C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CNN2-PPP1R12C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CNN2-PPP1R12C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCNN2C0007134Renal Cell Carcinoma1CTD_human
HgeneCNN2C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
HgeneCNN2C1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneCNN2C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneCNN2C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneCNN2C1306837Papillary Renal Cell Carcinoma1CTD_human